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Anurag Tandon

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Robert H C Chen; Paul E Fraser; Tammy Langman; Diana Marsilio; Filsy Samuel; Naomi P Visanji; Sabine Wislet-Gendebien; Gang Zhang; Anurag Tandon
α-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity.
Gang Zhang; Anurag Tandon
Quantitative assessment on the cloning efficiencies of lentiviral transfer vectors with a unique clone site.
Naomi P Visanji; Sabine Wislet-Gendebien; Gang Zhang; Isabelle Aubert; Paul E Fraser; Loren W Oschipok; Anurag Tandon
Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes.

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All Publications

2013: Robert H C Chen; Paul E Fraser; Tammy Langman; Diana Marsilio; Filsy Samuel; Naomi P Visanji; Sabine Wislet-Gendebien; Gang Zhang; Anurag Tandon
α-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity.
The Journal of biological chemistry 2013;288(11):7438-49.
2012: Gang Zhang; Anurag Tandon
Quantitative assessment on the cloning efficiencies of lentiviral transfer vectors with a unique clone site.
Scientific reports 2012;2():1-8.
2011: Naomi P Visanji; Sabine Wislet-Gendebien; Gang Zhang; Isabelle Aubert; Paul E Fraser; Loren W Oschipok; Anurag Tandon
Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes.
The Journal of biological chemistry 2011;286(41):35863-73.
2010: Melanie Dyllick-Brenzinger; Cheryl A D'Souza; Burkhardt Dahlmann; Peter-Michael Kloetzel; Anurag Tandon
Reciprocal effects of alpha-synuclein overexpression and proteasome inhibition in neuronal cells and tissue.
Neurotoxicity research 2010;17(3):215-27.
2008: M Emdadul Haque; Kelly J Thomas; Cheryl D'Souza; Steven M Callaghan; Tohru Kitada; ruth slack; Paul E Fraser; Mark Cookson; Anurag Tandon; David Park
Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(5):1716-21.
2008: Sabine Wislet-Gendebien; Naomi P Visanji; Shawn N Whitehead; Diana Marsilio; Weimin Hou; Daniel Figeys; Paul E Fraser; Steffany A L Bennett; Anurag Tandon
Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors.
BMC neuroscience 2008;9():92.
2006: Sabine Wislet-Gendebien; Cheryl A D'Souza; Toshitaka Kawarai; Peter St George-Hyslop; David Westaway; Paul E Fraser; Anurag Tandon
Cytosolic proteins regulate alpha-synuclein dissociation from presynaptic membranes.
The Journal of biological chemistry 2006;281(43):32148-55.
2006: Fusheng Chen; Hiroshi Hasegawa; Gerold Schmitt-Ulms; Toshitaka Kawarai; Christopher Bohm; Taiichi Katayama; Yongjun Gu; Nobuo Sanjo; Michael Glista; Ekaterina Rogaeva; Yosuke Wakutani; Raphaëlle Pardossi-Piquard; Xueying Ruan; Anurag Tandon; Frédéric Checler; Philippe Marambaud; Kirk Hansen; David Westaway; Peter St George-Hyslop; Paul E Fraser
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Nature 2006;440(7088):1208-12.
2005: Agnes Petit; Toshitaka Kawarai; Erwan Paitel; Nobuo Sanjo; Mary Maj; Michael Scheid; Fusheng Chen; Yongjun Gu; Hiroshi Hasegawa; Shabnam Salehi-Rad; Linda Wang; Ekaterina Rogaeva; Paul E Fraser; Brian Robinson; Peter St George-Hyslop; Anurag Tandon
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations.
The Journal of biological chemistry 2005;280(40):34025-32.
2004: Ekaterina Rogaeva; Janel Johnson; Anthony E Lang; Cindy Gulick; Katrina Gwinn-Hardy; Toshitaka Kawarai; Christine Sato; Angharad Morgan; John Werner; Robert L Nussbaum; Agnes Petit; Michael S Okun; Aideen McInerney; Ronald Mandel; Justus L Groen; Hubert H Fernandez; Ronald B Postuma; Kelly D Foote; Shabnam Salehi-Rad; Yan Liang; Sharon Reimsnider; Anurag Tandon; John Hardy; Peter St George-Hyslop; Andrew Singleton
Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease.
Archives of neurology 2004;61(12):1898-904.
2004: Euijung Jo; Audrey A Darabie; Kyung Han; Anurag Tandon; Paul E Fraser; JoAnne McLaurin
alpha-Synuclein-synaptosomal membrane interactions: implications for fibrillogenesis.
European journal of biochemistry / FEBS 2004;271(15):3180-9.
2003: Anurag Tandon; Haung Yu; Linda Wang; Ekaterina Rogaeva; Christine Sato; M Azhar Chishti; Toshitaka Kawarai; Hiroshi Hasegawa; Fusheng Chen; Peter Davies; Paul E Fraser; David Westaway; Peter St George-Hyslop
Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles.
Journal of neurochemistry 2003;86(3):572-81.
2003: Fusheng Chen; Anurag Tandon; Nobuo Sanjo; Yong-Jun Gu; Hiroshi Hasegawa; Shigeki Arawaka; Frank J S Lee; Xueying Ruan; Peter Mastrangelo; Serap Erdebil; Linda Wang; David Westaway; Howard T J Mount; Bruce A Yankner; Paul E Fraser; Peter St George-Hyslop
Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
The Journal of biological chemistry 2003;278(22):19974-9.
2003: Yongjun Gu; Fusheng Chen; Nobuo Sanjo; Toshitaka Kawarai; Hiroshi Hasegawa; Monika Duthie; Wenping Li; Xueying Ruan; Anchla Luthra; Howard T J Mount; Anurag Tandon; Paul E Fraser; Peter St George-Hyslop
APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes.
The Journal of biological chemistry 2003;278(9):7374-80.
2002: Shigeki Arawaka; Hiroshi Hasegawa; Anurag Tandon; Christopher Janus; Fusheng Chen; Gang G. Yu; Kenji Kikuchi; Shingo Koyama; Takeo Kato; Paul E Fraser; Peter St George-Hyslop
The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein.
Journal of neurochemistry 2002;83(5):1065-71.
2002: Anurag Tandon; Paul E Fraser
The presenilins.
Genome biology 2002;3(11):reviews3014.
2002: Dun-Sheng Yang; Anurag Tandon; Fusheng Chen; Gang G. Yu; Haung Yu; Shigeki Arawaka; Hiroshi Hasegawa; Monika Duthie; Stephen D Schmidt; Triprayer V Ramabhadran; Ralph A. Nixon; Paul Mathews; Sam Gandy; Howard T J Mount; Peter St George-Hyslop; Paul E Fraser
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins.
The Journal of biological chemistry 2002;277(31):28135-42.
2001: Fusheng Chen; Gang G. Yu; Shigeki Arawaka; M Nishimura; Toshitaka Kawarai; Haung Yu; Anurag Tandon; Agnes Supala; You-Qiang Song; Ekaterina Rogaeva; P Milman; Christine Sato; C Yu; Christopher Janus; J Lee; L Song; Liyong Zhang; Paul E Fraser; Peter St George-Hyslop
Nicastrin binds to membrane-tethered Notch.
Nature cell biology 2001;3(8):751-4.
2000: Fusheng Chen; Dun-Sheng Yang; Suzana Petanceska; Austin Yang; Anurag Tandon; Gang G. Yu; Richard Rozmahel; Jorge Ghiso; M Nishimura; DM Zhang; Toshitaka Kawarai; Georges Levesque; J Mills; L Levesque; You-Qiang Song; Ekaterina Rogaeva; David Westaway; Howard T J Mount; Sam Gandy; Peter St George-Hyslop; Paul E Fraser
Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
The Journal of biological chemistry 2000;275(47):36794-802.
2000: DM Zhang; D Levitan; Gang G. Yu; M Nishimura; Fusheng Chen; Anurag Tandon; Toshitaka Kawarai; Shigeki Arawaka; Agnes Supala; You-Qiang Song; Ekaterina Rogaeva; Yan Liang; E Holmes; P Milman; Christine Sato; Liyong Zhang; Peter St George-Hyslop
Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased A beta42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans.
Neuroreport 2000;11(14):3227-30.
2000: Gang G. Yu; M Nishimura; Shigeki Arawaka; D Levitan; Liyong Zhang; Anurag Tandon; You-Qiang Song; Ekaterina Rogaeva; Fusheng Chen; Toshitaka Kawarai; Agnes Supala; L Levesque; Haung Yu; Dun-Sheng Yang; E Holmes; P Milman; Yan Liang; DM Zhang; D H Xu; Christine Sato; Evgeny I Rogaev; M Smith; Christopher Janus; Y Zhang; R Aebersold; Lindsay A Farrer; Sandro Sorbi; Amalia C Bruni; Paul E Fraser; Peter St George-Hyslop
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
Nature 2000;407(6800):48-54.
2000: Gang G. Yu; Fusheng Chen; M Nishimura; H Steiner; Anurag Tandon; Toshitaka Kawarai; Shigeki Arawaka; Agnes Supala; You-Qiang Song; Ekaterina Rogaeva; E Holmes; DM Zhang; P Milman; Paul E Fraser; Christian Haass; Peter St George-Hyslop
Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes.
The Journal of biological chemistry 2000;275(35):27348-53.
2000: Anurag Tandon; Ekaterina Rogaeva; Michael Mullan; Peter St George-Hyslop
Molecular genetics of Alzheimer's disease: the role of beta-amyloid and the presenilins.
Current opinion in neurology 2000;13(4):377-84.
2000: Gang G. Yu; Fusheng Chen; M Nishimura; H Steiner; Anurag Tandon; Toshitaka Kawarai; Shigeki Arawaka; Agnes Supala; You-Qiang Song; Ekaterina Rogaeva; E Holmes; DM Zhang; P Milman; Paul E Fraser; Christian Haass; Peter St George-Hyslop
Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes.
Acta neurologica Scandinavica. Supplementum 2000;176():6-11.