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Heikki Tanila

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Kestutis Gurevicius; Arto Lipponen; Heikki Tanila
Increased cortical and thalamic excitability in freely moving APPswe/PS1dE9 mice modeling epileptic activity associated with Alzheimer's disease.
Misha Zilberter; Sofya Ziyatdinova; Alan Alpár; Catherine H Botting; Lívia Fülöp; Tibor Harkany; Anton Ivanov; Anton Malkov; Marat Mukhtarov; Alex A Osypov; Asla Pitkänen; Heikki Tanila; Giuseppe Tortoriello; Yuri Zilberter
Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease.
Helena Janíčková; Vladimír Rudajev; Heikki Tanila; Pavel Zimčík; Esam E El-Fakahany; Jan Jakubik; Vladimír Doležal
Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid β(1-42).

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2013: Kestutis Gurevicius; Arto Lipponen; Heikki Tanila
Increased cortical and thalamic excitability in freely moving APPswe/PS1dE9 mice modeling epileptic activity associated with Alzheimer's disease.
Cerebral cortex (New York, N.Y. : 1991) 2013;23(5):1148-58.
2013: Misha Zilberter; Sofya Ziyatdinova; Alan Alpár; Catherine H Botting; Lívia Fülöp; Tibor Harkany; Anton Ivanov; Anton Malkov; Marat Mukhtarov; Alex A Osypov; Asla Pitkänen; Heikki Tanila; Giuseppe Tortoriello; Yuri Zilberter
Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease.
Journal of neurochemistry 2013;125(1):157-71.
2013: Helena Janíčková; Vladimír Rudajev; Heikki Tanila; Pavel Zimčík; Esam E El-Fakahany; Jan Jakubik; Vladimír Doležal
Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid β(1-42).
Neuropharmacology 2013;67():272-83.
2013: Dávid Lendvai; Markus Morawski; László Négyessy; Heikki Tanila; Thomas Arendt; Johannes Attems; Gábor Baksa; Georgina Gáti; Tibor Glasz; Tibor Harkany; Carsten Jäger; Alán Alpár
Neurochemical mapping of the human hippocampus reveals perisynaptic matrix around functional synapses in Alzheimer's disease.
Acta neuropathologica 2013;125(2):215-29.
2013: Saila Vepsäläinen; Gary Dobson; Annakaisa Haapasalo; Reijo O Karjalainen; Henna Koivisto; Petra Mäkinen; Gordon J McDougall; Elina Pekkarinen; Derek Stewart; Heikki Tanila; Mikko Hiltunen
Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease.
The Journal of nutritional biochemistry 2013;24(1):360-70.
2012: Susanna Kemppainen; Serge Laroche; Gregoire Lavasseur; Tiago F Outeiro; Tomi Rantamäki; Ana M Sebastião; Saara Stavén; Henri Autio; Eero Castrén; Sabrina Davis; Maria J Diógenes; André Jerónimo-Santos; Elisa Kärkkäinen; Nina Karpova; Hugo Vicente Miranda; Heikki Tanila
Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice.
Neurobiology of aging 2012;33(6):1122.e23-39.
2012: Mikko Hiltunen; Susanna Kemppainen; Vinoth K M Khandelwal; Henna Koivisto; Marine Krzisch; Markku Laakso; Petra Mäkinen; Pasi Miettinen; Hilkka Soininen; Tea Tiilikainen; Maija Tusa; Saila Vepsäläinen; Nagendra Yaluri; Annakaisa Haapasalo; Heikki Tanila
Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice.
Journal of cellular and molecular medicine 2012;16(6):1206-22.
2012: Heramb Chadchankar; Jouni Ihalainen; Heikki Tanila; Leonid Yavich
Methylphenidate modifies overflow and presynaptic compartmentalization of dopamine via an α-synuclein-dependent mechanism.
The Journal of pharmacology and experimental therapeutics 2012;341(2):484-92.
2012: Johannes Attems; Alan Alpar; Mathias Heikenwalder; Tomas G M Hökfelt; Shane McParland; Lauren Spence; Heikki Tanila; Mathias Uhlén; Tibor Harkany
Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(16):6259-64.
2012: Arto Lipponen; Kestutis Gurevicius; Bisrat T Woldemichael; Heikki Tanila
Artificial theta stimulation impairs encoding of contextual fear memory.
PloS one 2012;7(11):e48506.
2012: Heikki Tanila
Wading pools, fading memories-place navigation in transgenic mouse models of Alzheimer's disease.
Frontiers in aging neuroscience 2012;4():11.
2012: Lakshman Puli; Jari Koistinaho; Tarja Malm; Katja Olas; Yuriy Pomeshchik; Heikki Tanila
Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer's disease.
Journal of neuroinflammation 2012;9():105.
2011: Pauliina Korhonen; Sergiy Kyrylenko; E M Mandelkow; Johanna Ojala; Erik Peltomaa; Antero Salminen; M-L Soininen; Heikki Tanila; A Thornell; Thomas van Groen; Hilkka Soininen
Characterization of a novel transgenic rat carrying human tau with mutation P301L.
Neurobiology of aging 2011;32(12):2314-5.
2011: Rea Pihlaja; Jouko Sandholm; Heikki Tanila; Riitta Kauppinen; Jari Koistinaho; Milla Koistinaho
Multiple cellular and molecular mechanisms are involved in human Aβ clearance by transplanted adult astrocytes.
Glia 2011;59(11):1643-57.
2011: Marcus Otto Walter Grimm; Sven Grösgen; Matthias Riemenschneider; Heikki Tanila; Heike S Grimm; Tobias Hartmann
From brain to food: analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin-plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry.
Journal of chromatography. A 2011;1218(42):7713-22.
2011: Jouni A Ihalainen; Susanna Kemppainen; Pekka Keski-Rahkonen; Marko Lehtonen; Doug Rasmusson; Timo Sarajärvi; Kazue Semba; Pradeep K Banerjee; Heikki Tanila
Effects of memantine and donepezil on cortical and hippocampal acetylcholine levels and object recognition memory in rats.
Neuropharmacology 2011;61(5-6):891-9.
2011: Jan Mulder; Misha Zilberter; Susana J Pasquaré; Alán Alpár; Gunnar Schulte; Samira G Ferreira; Attila Köfalvi; Ana M Martín-Moreno; Erik Keimpema; Heikki Tanila; Masahiko Watanabe; Ken Mackie; Tibor Hortobágyi; María L de Ceballos; Tibor Harkany
Molecular reorganization of endocannabinoid signalling in Alzheimer's disease.
Brain : a journal of neurology 2011;134(Pt 4):1041-60.
2011: Heramb Chadchankar; Jouni Ihalainen; Heikki Tanila; Leonid Yavich
Decreased reuptake of dopamine in the dorsal striatum in the absence of α-synuclein.
Brain research 2011;1382():37-44.
2011: Sofya Ziyatdinova; Kestutis Gurevicius; Nino Kutchiashvili; Tamuna Bolkvadze; Jari Nissinen; Heikki Tanila; Asla Pitkänen
Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels.
Epilepsy research 2011;94(1-2):75-85.
2011: Carina Halleskog; Jan Mulder; Jenny Dahlström; Ken Mackie; Tibor Hortobágyi; Heikki Tanila; Lakshman Kumar Puli; Katrin Färber; Tibor Harkany; Gunnar Schulte
WNT signaling in activated microglia is proinflammatory.
Glia 2011;59(1):119-31.
2010: Karolina Rasi; Merja Hurskainen; Mika Kallio; Saara Stavén; Raija Sormunen; Anthony M Heape; Robin L Avila; Daniel Kirschner; Anu Muona; Uolevi Tolonen; Heikki Tanila; P Huhtala; Raija Soininen; Taina Pihlajaniemi
Lack of collagen XV impairs peripheral nerve maturation and, when combined with laminin-411 deficiency, leads to basement membrane abnormalities and sensorimotor dysfunction.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(43):14490-501.
2010: Jouni Ihalainen; Timo Sarajärvi; Susanna Kemppainen; Pekka Keski-Rahkonen; Marko Lehtonen; Heikki Tanila
A novel delayed non-match to sample object recognition task that allows simultaneous in vivo microdialysis.
Journal of neuroscience methods 2010;189(2):210-5.
2010: Eva Machová; Vladimír Rudajev; Helena Smycková; Henna Koivisto; Heikki Tanila; Vladimír Dolezal
Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice.
Neurobiology of disease 2010;38(1):27-35.
2010: Johanna Magga; Lakshman Puli; Rea Pihlaja; Katja Kanninen; Suvi Neulamaa; Tarja Malm; Wolfgang Härtig; Jens Grosche; Gundars Goldsteins; Heikki Tanila; Jari Koistinaho; Milla Koistinaho
Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease.
Journal of neuroinflammation 2010;7():90.
2010: George M Alley; Jason A Bailey; Demao Chen; Balmiki Ray; Lakshman K Puli; Heikki Tanila; Pradeep K Banerjee; Debomoy K Lahiri
Memantine lowers amyloid-beta peptide levels in neuronal cultures and in APP/PS1 transgenic mice.
Journal of neuroscience research 2010;88(1):143-54.
2009: Kestutis Gurevicius; Fang Kuang; Luminita Stoenica; Andrey Irintchev; Irina Gureviciene; Alexander Dityatev; Melitta Schachner; Heikki Tanila
Genetic ablation of tenascin-C expression leads to abnormal hippocampal CA1 structure and electrical activity in vivo.
Hippocampus 2009;19(12):1232-46.
2009: Katja Kanninen; Riikka Heikkinen; Tarja M Malm; Taisia Rolova; Susanna Kuhmonen; Hanna Leinonen; Seppo Ylä-Herttuala; Heikki Tanila; Anna-Liisa Levonen; Milla Koistinaho; Jari Koistinaho
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16505-10.
2009: Sami Myllymaa; Katja Myllymaa; Hannu Korhonen; Juha Töyräs; Juha E Jääskeläinen; Kaj Djupsund; Heikki Tanila; Reijo Lappalainen
Fabrication and testing of polyimide-based microelectrode arrays for cortical mapping of evoked potentials.
Biosensors & bioelectronics 2009;24(10):3067-72.
2009: Rimante Minkeviciene; Sylvain Rheims; Marton B Dobszay; Misha Zilberter; Jarmo Hartikainen; Lívia Fülöp; Botond Penke; Yuri Zilberter; Tibor Harkany; Asla Pitkänen; Heikki Tanila
Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(11):3453-62.
2009: Mari Oksman; Heikki Tanila; Leonid Yavich
Behavioural and neurochemical response of alpha-synuclein A30P transgenic mice to the effects of L-DOPA.
Neuropharmacology 2009;56(3):647-52.
2009: Anne M Jauhiainen; Maija Pihlajamäki; Susanna Tervo; Eini Niskanen; Heikki Tanila; Tuomo Hänninen; Ritva Vanninen; Hilkka Soininen
Discriminating accuracy of medial temporal lobe volumetry and fMRI in mild cognitive impairment.
Hippocampus 2009;19(2):166-75.
2009: Johanna Ojala; Irina Alafuzoff; Sanna-Kaisa Herukka; Thomas van Groen; Heikki Tanila; Tuula Pirttilä
Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients.
Neurobiology of aging 2009;30(2):198-209.
2008: Katja Kanninen; Tarja M Malm; Henna-Kaisa Jyrkkänen; Gundars Goldsteins; Velta Keksa-Goldsteine; Heikki Tanila; Masayuki Yamamoto; Seppo Ylä-Herttuala; Anna-Liisa Levonen; Jari Koistinaho
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid.
Molecular and cellular neurosciences 2008;39(3):302-13.
2008: Xin-Wen Zhou; Jan-�ke GUSTAFSSON; Heikki Tanila; Cecilia Bjorkdahl; Rong Liu; Bengt Winblad; Jin-Jing Pei
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.
Neurobiology of disease 2008;31(3):386-94.
2008: Saila Vepsäläinen; Mikko Hiltunen; Seppo Helisalmi; Jun Wang; Thomas van Groen; Heikki Tanila; Hilkka Soininen
Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology.
Neuroscience letters 2008;438(2):216-20.
2008: Rimante Minkeviciene; Pradeep Banerjee; Heikki Tanila
Cognition-enhancing and anxiolytic effects of memantine.
Neuropharmacology 2008;54(7):1079-85.
2008: R Minkeviciene; Jouni A Ihalainen; Tarja M Malm; O Matilainen; Velta Keksa-Goldsteine; Gundars Goldsteins; Hennariikka Iivonen; N Leguit; J Glennon; Jari Koistinaho; P Banerjee; Heikki Tanila
Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice.
Journal of neurochemistry 2008;105(3):584-94.
2008: Eva Machová; Jan Jakubik; Pavel Michal; Mari Oksman; Hennariikka Iivonen; Heikki Tanila; Vladimír Dolezal
Impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mice.
Neurobiology of aging 2008;29(3):368-78.
2008: Xin-Wen Zhou; Heikki Tanila; Jin-Jing Pei
Parallel increase in p70 kinase activation and tau phosphorylation (S262) with Abeta overproduction.
FEBS letters 2008;582(2):159-64.
2008: Sami Myllymaa; Katja Myllymaa; Hannu Korhonen; Irina Gureviciene; Kaj Djupsund; Heikki Tanila; Reijo Lappalainen
Development of flexible microelectrode arrays for recording cortical surface field potentials.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2008;2008():3200-3.
2008: R Liu; Xin-Wen Zhou; Heikki Tanila; C Bjorkdahl; Jian-Zhi Wang; Zhi-Zhong Guan; Yihai Cao; Jan-�ke GUSTAFSSON; Bengt Winblad; Jin-Jing Pei
Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology.
Journal of cellular and molecular medicine 2008;12(1):241-57.
2007: Anne Hämäläinen; Maija Pihlajamäki; Heikki Tanila; Tuomo Hänninen; Eini Niskanen; Susanna Tervo; Pasi A Karjalainen; Ritva Vanninen; Hilkka Soininen
Increased fMRI responses during encoding in mild cognitive impairment.
Neurobiology of aging 2007;28(12):1889-903.
2007: Carlijn R Hooijmans; Coen Graven; Pieter J W C Dederen; Heikki Tanila; Thomas van Groen; Amanda J Kiliaan
Amyloid beta deposition is related to decreased glucose transporter-1 levels and hippocampal atrophy in brains of aged APP/PS1 mice.
Brain research 2007;1181():93-103.
2007: Timo Heikki Kumlin; Hennariikka Iivonen; Pasi Miettinen; Antti Juvonen; Thomas van Groen; Lauri Puranen; Risto Pitkäaho; Jukka Juutilainen; Heikki Tanila
Mobile phone radiation and the developing brain: behavioral and morphological effects in juvenile rats.
Radiation research 2007;168(4):471-9.
2007: C R Hooijmans; F Rutters; Pieter J W C Dederen; Giulio Gambarota; Andor A Veltien; Thomas van Groen; Laus M Broersen; D Lütjohann; Arend Heerschap; Heikki Tanila; Amanda J Kiliaan
Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD).
Neurobiology of disease 2007;28(1):16-29.
2007: Irina Gureviciene; Kestutis Gurevicius; Heikki Tanila
Role of alpha-synuclein in synaptic glutamate release.
Neurobiology of disease 2007;28(1):83-9.
2007: Leonid Yavich; Heikki Tanila
Mechanics of self-stimulation and dopamine release in the nucleus accumbens.
Neuroreport 2007;18(12):1271-4.
2007: Tarja M Malm; Hennariikka Iivonen; Gundars Goldsteins; Velta Keksa-Goldsteine; Toni Ahtoniemi; Katja Kanninen; Antero Salminen; Seppo Auriola; Thomas van Groen; Heikki Tanila; Jari Koistinaho
Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(14):3712-21.
2007: Karen C Cheung; Philippe Renaud; Heikki Tanila; Kaj Djupsund
Flexible polyimide microelectrode array for in vivo recordings and current source density analysis.
Biosensors & bioelectronics 2007;22(8):1783-90.
2007: Kestutis Gurevicius; Irina Gureviciene; Elena Sivukhina; Andrey Irintchev; Melitta Schachner; Heikki Tanila
Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase.
Molecular and cellular neurosciences 2007;34(2):189-98.
2006: Iain A Wilson; Michela Gallagher; Howard Eichenbaum; Heikki Tanila
Neurocognitive aging: prior memories hinder new hippocampal encoding.
Trends in neurosciences 2006;29(12):662-70.
2006: Leonid Yavich; Pekka Jäkälä; Heikki Tanila
Abnormal compartmentalization of norepinephrine in mouse dentate gyrus in alpha-synuclein knockout and A30P transgenic mice.
Journal of neurochemistry 2006;99(3):724-32.
2006: Michela Gallagher; Rebecca P Haberman; Peter R Rapp; Heikki Tanila; Carlo Colantuoni; Howard Eichenbaum; Iain A Wilson
Individual differences in neurocognitive aging of the medial temporal lobe.
Age (Dordrecht, Netherlands) 2006;28(3):221-33.
2006: Mari Oksman; Hennariikka Iivonen; E Hogyes; Z Amtul; B Penke; I Leenders; Laus M Broersen; D Lütjohann; Tobias Hartmann; Heikki Tanila
Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice.
Neurobiology of disease 2006;23(3):563-72.
2006: Mari Oksman; Heikki Tanila; Leonid Yavich
Brain reward in the absence of alpha-synuclein.
Neuroreport 2006;17(11):1191-4.
2006: Eero Castrén; Heikki Tanila
Neurotrophins and dementia--keeping in touch.
Neuron 2006;51(1):1-3.
2006: Isaac Shemer; Carl Holmgren; Rogier Min; Livia Fülöp; Misha Zilberter; Kyle M Sousa; Tamás Farkas; Wolfgang Härtig; Botond Penke; Nail Burnashev; Heikki Tanila; Yuri Zilberter; Tibor Harkany
Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors.
The European journal of neuroscience 2006;23(8):2035-47.
2006: Iain Wilson; Heikki Tanila
[Not Available].
Duodecim; lääketieteellinen aikakauskirja 2006;122(11):1323-9.
2006: Susan Iivonen; Taneli Heikkinen; Jukka Puoliväli; Seppo Helisalmi; Mikko Hiltunen; Hilkka Soininen; Heikki Tanila
Effects of estradiol on spatial learning, hippocampal cytochrome P450 19, and estrogen alpha and beta mRNA levels in ovariectomized female mice.
Neuroscience 2006;137(4):1143-52.
2005: Leonid Yavich; Pekka Jäkälä; Heikki Tanila
Noradrenaline overflow in mouse dentate gyrus following locus coeruleus and natural stimulation: real-time monitoring by in vivo voltammetry.
Journal of neurochemistry 2005;95(3):641-50.
2005: Leonid Yavich; Mari Oksman; Heikki Tanila; Petri Kerokoski; Mikko Hiltunen; Thomas van Groen; Jukka Puoliväli; Pekka T Männistö; Arturo García-Horsman; Ewen MacDonald; Konrad Beyreuther; Tobias Hartmann; Pekka Jäkälä
Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein.
Neurobiology of disease 2005;20(2):303-13.
2005: Sargo Aalto; Jouni A Ihalainen; Jussi Hirvonen; Jaana Kajander; Harry Scheinin; Heikki Tanila; Kjell Någren; Harry Vilkman; Lars ´Gustafsson; Erkka Syvälahti; Jarmo Hietala
Cortical glutamate-dopamine interaction and ketamine-induced psychotic symptoms in man.
Psychopharmacology 2005;182(3):375-83.
2005: Maija Pihlajamäki; Heikki Tanila; Mervi Könönen; Tuomo Hänninen; Hannu J Aronen; Hilkka Soininen
Distinct and overlapping fMRI activation networks for processing of novel identities and locations of objects.
The European journal of neuroscience 2005;22(8):2095-105.
2005: Iain A Wilson; Sami Ikonen; Michela Gallagher; Howard Eichenbaum; Heikki Tanila
Age-associated alterations of hippocampal place cells are subregion specific.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(29):6877-86.
2005: Iain A Wilson; Sami Ikonen; Kestutis Gurevicius; Robert W McMahan; Michela Gallagher; Howard Eichenbaum; Heikki Tanila
Place cells of aged rats in two visually identical compartments.
Neurobiology of aging 2005;26(7):1099-106.
2005: Asa Petersén; Joana Gil; Marion L C Maat-Schieman; Maria Björkqvist; Heikki Tanila; Inês M Araújo; Ruben Smith; Natalija Popovic; Nils Wierup; Per Norlén; Jia-Yi Li; Raymund A C Roos; Frank Sundler; Hindrik Mulder; Patrik Brundin
Orexin loss in Huntington's disease.
Human molecular genetics 2005;14(1):39-47.
2004: Leonid Yavich; Heikki Tanila; Saila Vepsäläinen; Pekka Jäkälä
Role of alpha-synuclein in presynaptic dopamine recruitment.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(49):11165-70.
2004: Jussi Väisänen; Jouni A Ihalainen; Heikki Tanila; Eero Castrén
Effects of NMDA-receptor antagonist treatment on c-fos expression in rat brain areas implicated in schizophrenia.
Cellular and molecular neurobiology 2004;24(6):769-80.
2004: Li Liu; Sanna-Kaisa Herukka; Rimante Minkeviciene; Thomas van Groen; Heikki Tanila
Longitudinal observation on CSF Abeta42 levels in young to middle-aged amyloid precursor protein/presenilin-1 doubly transgenic mice.
Neurobiology of disease 2004;17(3):516-23.
2004: Rimante Minkeviciene; Pradeep Banerjee; Heikki Tanila
Memantine improves spatial learning in a transgenic mouse model of Alzheimer's disease.
The Journal of pharmacology and experimental therapeutics 2004;311(2):677-82.
2004: Jouni A Ihalainen; Heikki Tanila
In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse nucleus accumbens.
Journal of neurochemistry 2004;91(1):49-56.
2004: Taneli Heikkinen; Jukka Puoliväli; Heikki Tanila
Effects of long-term ovariectomy and estrogen treatment on maze learning in aged mice.
Experimental gerontology 2004;39(9):1277-83.
2004: Selma K Kaasinen; Mari Oksman; Leena Alhonen; Heikki Tanila; Juhani Jänne
Spermidine/spermine N1-acetyltransferase overexpression in mice induces hypoactivity and spatial learning impairment.
Pharmacology, biochemistry, and behavior 2004;78(1):35-45.
2004: Taneli Heikkinen; Giedrius Kalesnykas; Aila Rissanen; Tero Tapiola; Susan Iivonen; Jun Wang; J Chaudhuri; Heikki Tanila; Riitta Miettinen; Jukka Puoliväli
Estrogen treatment improves spatial learning in APP + PS1 mice but does not affect beta amyloid accumulation and plaque formation.
Experimental neurology 2004;187(1):105-17.
2004: Iain A Wilson; Sami Ikonen; Irina Gureviciene; Robert W McMahan; Michela Gallagher; Howard Eichenbaum; Heikki Tanila
Cognitive aging and the hippocampus: how old rats represent new environments.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(15):3870-8.
2004: Maija Pihlajamäki; Heikki Tanila; Mervi Könönen; Tuomo Hänninen; Anne Hämäläinen; Hilkka Soininen; Hannu J Aronen
Visual presentation of novel objects and new spatial arrangements of objects differentially activates the medial temporal lobe subareas in humans.
The European journal of neuroscience 2004;19(7):1939-49.
2004: Kestutis Gurevicius; Irina Gureviciene; Antti Valjakka; Melitta Schachner; Heikki Tanila
Enhanced cortical and hippocampal neuronal excitability in mice deficient in the extracellular matrix glycoprotein tenascin-R.
Molecular and cellular neurosciences 2004;25(3):515-23.
2004: Irina Gureviciene; Sami Ikonen; Kestutis Gurevicius; A Sarkaki; Thomas van Groen; Raimo Pussinen; Aarne Ylinen; Heikki Tanila
Normal induction but accelerated decay of LTP in APP + PS1 transgenic mice.
Neurobiology of disease 2004;15(2):188-95.
2003: Jun Wang; Heikki Tanila; Jukka Puoliväli; Inga Kadish; Thomas van Groen
Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice.
Neurobiology of disease 2003;14(3):318-27.
2003: Hennariikka Iivonen; Liisa Nurminen; Mikko Harri; Heikki Tanila; Jukka Puoliväli
Hypothermia in mice tested in Morris water maze.
Behavioural brain research 2003;141(2):207-13.
2003: Iain A Wilson; Sami Ikonen; Robert W McMahan; Michela Gallagher; Howard Eichenbaum; Heikki Tanila
Place cell rigidity correlates with impaired spatial learning in aged rats.
Neurobiology of aging 2003;24(2):297-305.
2003: Li Liu; Tero Tapiola; Sanna-Kaisa Herukka; Matti Heikkilä; Heikki Tanila
Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice.
Neuroreport 2003;14(1):163-6.
2003: Maija Pihlajamäki; Heikki Tanila; Tuomo Hänninen; Mervi Könönen; Mia Mikkonen; Ville Jalkanen; Kaarina Partanen; Hannu J Aronen; Hilkka Soininen
Encoding of novel picture pairs activates the perirhinal cortex: an fMRI study.
Hippocampus 2003;13(1):67-80.
2003: Jun Wang; Sami Ikonen; Kestutis Gurevicius; Thomas van Groen; Heikki Tanila
Altered auditory-evoked potentials in mice carrying mutated human amyloid precursor protein and presenilin-1 transgenes.
Neuroscience 2003;116(2):511-7.
2003: Irina Gureviciene; Jukka Puoliväli; Raimo Pussinen; Jun Wang; Heikki Tanila; Aarne Ylinen
Estrogen treatment alleviates NMDA-antagonist induced hippocampal LTP blockade and cognitive deficits in ovariectomized mice.
Neurobiology of learning and memory 2003;79(1):72-80.
2002: Jukka Puoliväli; Markus Björklund; Maya Holmberg; Jouni A Ihalainen; Mika Scheinin; Heikki Tanila
Alpha 2C-adrenoceptor mediated regulation of cortical EEG arousal.
Neuropharmacology 2002;43(8):1305-12.
2002: Li Liu; Sami Ikonen; Tero Tapiola; Heikki Tanila; Thomas van Groen
Fimbria-fornix lesion does not affect APP levels and amyloid deposition in the hippocampus of APP+PS1 double transgenic mice.
Experimental neurology 2002;177(2):565-74.
2002: Li Liu; Sami Ikonen; Taneli Heikkinen; Matti Heikkilä; Jukka Puoliväli; Thomas van Groen; Heikki Tanila
Effects of fimbria-fornix lesion and amyloid pathology on spatial learning and memory in transgenic APP+PS1 mice.
Behavioural brain research 2002;134(1-2):433-45.
2002: Amelia Marutle; Christina Unger; Ewa Hellström-Lindahl; Jun Wang; Jukka Puoliväli; Heikki Tanila; agneta nordberg; Xiao Zhang
Elevated levels of Abeta1-40 and Abeta1-42 do not alter the binding sites of nicotinic receptor subtypes in the brain of APPswe and PS1 double transgenic mice.
Neuroscience letters 2002;328(3):269-72.
2002: Jun Wang; Sami Ikonen; Kestutis Gurevicius; Thomas van Groen; Heikki Tanila
Alteration of cortical EEG in mice carrying mutated human APP transgene.
Brain research 2002;943(2):181-90.
2002: Jouni A Ihalainen; Heikki Tanila
In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse prefrontal cortex.
The European journal of neuroscience 2002;15(11):1789-94.
2002: Jukka Puoliväli; Jun Wang; Taneli Heikkinen; Matti Heikkilä; Tero Tapiola; Thomas van Groen; Heikki Tanila
Hippocampal A beta 42 levels correlate with spatial memory deficit in APP and PS1 double transgenic mice.
Neurobiology of disease 2002;9(3):339-47.
2002: Taneli Heikkinen; Jukka Puoliväli; Li Liu; Anna Rissanen; Heikki Tanila
Effects of ovariectomy and estrogen treatment on learning and hippocampal neurotransmitters in mice.
Hormones and behavior 2002;41(1):22-32.
2002: Li Liu; Sami Ikonen; Taneli Heikkinen; Tero Tapiola; Thomas van Groen; Heikki Tanila
The effects of long-term treatment with metrifonate, a cholinesterase inhibitor, on cholinergic activity, amyloid pathology, and cognitive function in APP and PS1 doubly transgenic mice.
Experimental neurology 2002;173(2):196-204.
2002: Sami Ikonen; Robert W McMahan; Michela Gallagher; Howard Eichenbaum; Heikki Tanila
Cholinergic system regulation of spatial representation by the hippocampus.
Hippocampus 2002;12(3):386-97.
2001: Markus Björklund; I Siverina; Taneli Heikkinen; Heikki Tanila; Jukka Sallinen; Mika Scheinin; PJ Riekkinen
Spatial working memory improvement by an alpha2-adrenoceptor agonist dexmedetomidine is not mediated through alpha2C-adrenoceptor.
Progress in neuro-psychopharmacology & biological psychiatry 2001;25(8):1539-54.
2001: K S Laitinen; Thomas van Groen; Heikki Tanila; Jarkko I Venäläinen; Pekka T Männistö; Irina Alafuzoff
Brain prolyl oligopeptidase activity is associated with neuronal damage rather than beta-amyloid accumulation.
Neuroreport 2001;12(15):3309-12.
2001: Sami Ikonen; Heikki Tanila
Effects of metrifonate on the hippocampal theta rhythm of freely moving intact and MS-lesioned mice.
Pharmacology, biochemistry, and behavior 2001;69(1-2):165-72.
2001: Jouni A Ihalainen; Heikki Tanila; Mika Scheinin; PJ Riekkinen
alpha(2C)-Adrenoceptors modulate the effect of methylphenidate on response rate and discrimination accuracy in an operant test.
Brain research bulletin 2001;54(5):553-7.
2001: Heikki Tanila
[Heavy work, heavy amusements].
Duodecim; lääketieteellinen aikakauskirja 2001;117(4):439-41.
2001: Heikki Tanila
Noradrenergic regulation of hippocampal place cells.
Hippocampus 2001;11(6):793-808.
2000: Maija Pihlajamäki; Heikki Tanila; Tuomo Hänninen; Mervi Könönen; M Laakso; Kaarina Partanen; Hilkka Soininen; Hannu J Aronen
Verbal fluency activates the left medial temporal lobe: a functional magnetic resonance imaging study.
Annals of neurology 2000;47(4):470-6.
1999: Heikki Tanila; K Mustonen; Jukka Sallinen; Mika Scheinin; P Riekkinen
Role of alpha2C-adrenoceptor subtype in spatial working memory as revealed by mice with targeted disruption of the alpha2C-adrenoceptor gene.
The European journal of neuroscience 1999;11(2):599-603.
1999: Heikki Tanila
[What made the elderly lady feel dizzy?].
Duodecim; lääketieteellinen aikakauskirja 1999;115(10):1115,1117.
1999: Heikki Tanila
Hippocampal place cells can develop distinct representations of two visually identical environments.
Hippocampus 1999;9(3):235-46.
1998: Heikki Tanila; Markus Björklund; PJ Riekkinen
Cognitive changes in mice following moderate MPTP exposure.
Brain research bulletin 1998;45(6):577-82.
1998: Heikki Tanila
Unique features in the processing of spatial information by the aged hippocampus as shown by place cell recording studies: a response to Peter Rapp's commentary "Representational organization in the aged hippocampus".
Hippocampus 1998;8(5):436-7.
1997: Heikki Tanila; Perttu Sipilä; M Shapiro; Howard Eichenbaum
Brain aging: impaired coding of novel environmental cues.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(13):5167-74.
1997: Heikki Tanila; M Shapiro; Michela Gallagher; Howard Eichenbaum
Brain aging: changes in the nature of information coding by the hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(13):5155-66.
1997: ML Shapiro; Heikki Tanila; Howard Eichenbaum
Cues that hippocampal place cells encode: dynamic and hierarchical representation of local and distal stimuli.
Hippocampus 1997;7(6):624-42.
1997: Heikki Tanila; ML Shapiro; Howard Eichenbaum
Discordance of spatial representation in ensembles of hippocampal place cells.
Hippocampus 1997;7(6):613-23.