FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Rudolph Tanzi

Research Profile

Disorders

Chemicals & Drugs

Anatomy

Living Beings

Mouse

Procedures

Chromosome Mapping

Physiology

Concepts & Ideas

Co-author Network

Publications

TOP 3
Sang-Moon Yun; Sun-Jung Cho; Eui-Ju Choi; Chulman Jo; Sangmee Ahn Jo; Jae Chun Song; Sung Yeon Song; Rudolph E Tanzi; Keejung Yoon; Young Ho Koh
SUMO1 modulates Aβ generation via BACE1 accumulation.
Rudolph E Tanzi
A brief history of Alzheimer's disease gene discovery.
Paloma González-Pérez; Yubing Lu; Diane McKenna-Yasek; Peter C Sapp; Rudolph E Tanzi; Lars Bertram; Ru-Ju Chian; Fen-Biao Gao; Robert H Brown
Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Rudolph Tanzi (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Sang-Moon Yun; Sun-Jung Cho; Eui-Ju Choi; Chulman Jo; Sangmee Ahn Jo; Jae Chun Song; Sung Yeon Song; Rudolph E Tanzi; Keejung Yoon; Young Ho Koh
SUMO1 modulates Aβ generation via BACE1 accumulation.
Neurobiology of aging 2013;34(3):650-62.
2013: Rudolph E Tanzi
A brief history of Alzheimer's disease gene discovery.
Journal of Alzheimer's disease : JAD 2013;33 Suppl 1():S5-13.
2012: Paloma González-Pérez; Yubing Lu; Diane McKenna-Yasek; Peter C Sapp; Rudolph E Tanzi; Lars Bertram; Ru-Ju Chian; Fen-Biao Gao; Robert H Brown
Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS.
Neurobiology of disease 2012;48(3):391-8.
2012: Rudolph E Tanzi
The genetics of Alzheimer disease.
Cold Spring Harbor perspectives in medicine 2012;2(10):.
2012: Steven L Wagner; William C Mobley; Rudolph E Tanzi; Douglas Galasko
Potential use of γ-secretase modulators in the treatment of Alzheimer disease.
Archives of neurology 2012;69(10):1255-8.
2012: Xu Wu; Zhipeng Xu; Guohua Zhang; Yiying Zhang; Gregory Crosby; Deborah J Culley; Yuanlin Dong; Yan Lu; Edward R Marcantonio; Rudolph E Tanzi; Zhongcong Xie
The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β.
Neurobiology of aging 2012;33(7):1364-78.
2012: Yiying Zhang; Zhipeng Xu; Gregory Crosby; Deborah J Culley; Yuanlin Dong; Edward R Marcantonio; Hai Ning Shi; Rudolph E Tanzi; Hui Wang; Zhongcong Xie
Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory.
Annals of neurology 2012;71(5):687-98.
2012: Se Hoon Choi; Rudolph E Tanzi
iPSCs to the rescue in Alzheimer's research.
Cell stem cell 2012;10(3):235-6.
2012: Bin Zhang; Yu Zhen; Hui Zheng; Yun Yue; Shuren Li; Edward R Marcantonio; Janet Sherman; Rudolph E Tanzi; Ming Tian; Zhongcong Xie
The effects of isoflurane and desflurane on cognitive function in humans.
Anesthesia and analgesia 2012;114(2):410-5.
2012: Zhongcong Xie; Weiming Xia; Yuanlin Dong; Uta Maeda; Rudolph E Tanzi
RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing.
Translational neurodegeneration 2012;1(1):8.
2012: Lars Bertram; Rudolph E Tanzi
The genetics of Alzheimer's disease.
Progress in molecular biology and translational science 2012;107():79-100.
2012: Travis J A Craddock; Lee E Goldstein; Stuart R Hameroff; Noel Casey; Deepak Chopra; Jack A Tuszynski; Rudolph E Tanzi
The zinc dyshomeostasis hypothesis of Alzheimer's disease.
PloS one 2012;7(3):e33552.
2012: Sungho Won; Lars Bertram; Qing Lu; Rudolph E Tanzi; Christoph Lange
On the meta-analysis of genome-wide association studies: a robust and efficient approach to combine population and family-based studies.
Human heredity 2012;73(1):35-46.
2011: Sebastian Treusch; Julie S Valastyan; Kent E S Matlack; Anders Olofsson; Antonio Parrado; Eric M Reiman; Joshua M Shulman; Rudolph E Tanzi; Valeriya Baru; David A Bennett; Brooke J Bevis; Guy A Caldwell; Kim A Caldwell; Chee Yeun Chung; Philip L DeJager; Denis A Evans; Jessica L Goodman; Shusei Hamamichi; Haesun Han; Malin Lindhagen-Persson; Susan Lindquist
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.
Science (New York, N.Y.) 2011;334(6060):1241-5.
2011: Deborah J Culley; Koji Kojima; Arvind Palanisamy; Rudolph E Tanzi; Charles A Vacanti; Zhongcong Xie; Justin D Boyd; Gregory Crosby
Isoflurane decreases self-renewal capacity of rat cultured neural stem cells.
Anesthesiology 2011;115(4):754-63.
2011: Annakaisa Haapasalo; Lars Bertram; Nico P Dantuma; Kaisa Ma Kurkinen; Hilkka Soininen; Rudolph E Tanzi; Jayashree Viswanathan; Mikko Hiltunen
Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation.
Communicative & integrative biology 2011;4(4):428-32.
2011: Timo Sarajärvi; Jussi T Tuusa; Annakaisa Haapasalo; Jarkko J Lackman; Raija Sormunen; Seppo Helisalmi; Johannes T Roehr; Antonio R Parrado; Petra Mäkinen; Lars Bertram; Hilkka Soininen; Rudolph E Tanzi; Ulla E Petäjä-Repo; Mikko Hiltunen
Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking.
Molecular and cellular biology 2011;31(11):2326-40.
2011: A Li; M L McKee; J Moore; K Raygor; Donna M Romano; D A Schoenfeld; M J Serra; H F Cantiello; J G Fujimoto; H C Lee; T H Tsai; P Zhang; C Zhou; Rudolph E Tanzi
Changes in the expression of the Alzheimer’s disease-associated presenilin gene in drosophila heart leads to cardiac dysfunction.
Current Alzheimer research 2011;8(3):313-22.
2011: Adam C Naj; Gyungah Jun; Gary Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph Buxbaum; Gail P Jarvik; Paul K Crane; Eric B Larson; Thomas D Bird; Bradley F Boeve; Neill R Graff-Radford; Philip L De Jager; Denis Evans; Julie A Schneider; Minerva M Carrasquillo; Nilufer Ertekin-Taner; Steven G Younkin; Carlos Cruchaga; John S K Kauwe; Petra Nowotny; Patricia Kramer; John Hardy; Matthew Huentelman; Amanda Myers; M. Michael Barmada; F Yesim Demirci; Clinton T Baldwin; Robert C Green; Ekaterina Rogaeva; Steven E Arnold; Robert C Barber; Thomas Beach; Eileen H Bigio; James D Bowen; Adam Boxer; James R Burke; Nigel J Cairns; Chris S Carlson; Regina M Carney; Steven L Carroll; Helena C Chui; David G Clark; Jason Corneveaux; Carl W Cotman; Jeffrey L Cummings; Charles DeCarli; Steven T DeKosky; Ramon Diaz-Arrastia; Malcolm Dick; dennis dickson; William G Ellis; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas Galasko; Mary Ganguli; Marla Gearing; Daniel Geschwind; Bernardino Ghetti; John Gilbert; Sid Gilman; Bruno Giordani; Jonathan D Glass; John H Growdon; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence Honig; Christine M Hulette; Bradley T Hyman; Gregory A Jicha; Lee-Way Jin; Nancy Johnson; Jason Karlawish; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; James J Lah; Allan Levey; Andrew P Lieberman; Oscar L Lopez; Wendy J Mack; Daniel C Marson; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua Miller; Joseph E Parisi; Daniel P Perl; Elaine Peskind; Ronald C. Petersen; Wayne W Poon; Joseph F Quinn; Ruchita A Rajbhandary; Murray Raskind; Barry Reisberg; John M Ringman; Erik D Roberson; Roger N Rosenberg; Mary Sano; Lon S Schneider; William Seeley; Michael L Shelanski; Michael Slifer; Charles D Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; John Q Trojanowski; Juan C Troncoso; Vivianna M Van Deerlin; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Randall L Woltjer; Laura B Cantwell; Beth A Dombroski; Duane Beekly; Kathryn L Lunetta; Eden R Martin; M Ilyas Kamboh; Andrew J Saykin; Eric Reiman; David A Bennett; John C Morris; Thomas J Montine; Alison Goate; Deborah Blacker; Debby W Tsuang; Hakon Hakonarson; Walter A Kukull; Tatiana M Foroud; Jonathan L Haines; Richard Mayeux; Margaret Pericak-Vance; Lindsay A Farrer; Peter St George-Hyslop; Gerard D Schellenberg
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Nature genetics 2011;43(5):436-41.
2011: Jayashree Viswanathan; Annakaisa Haapasalo; Claudia Böttcher; Riitta Miettinen; Kaisa M A Kurkinen; Alice Lu; Anne Thomas; Christa J Maynard; Donna Romano; Bradley T Hyman; Oksana Berezovska; Lars Bertram; Hilkka Soininen; Nico P Dantuma; Rudolph E Tanzi; Mikko Hiltunen
Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation.
Traffic (Copenhagen, Denmark) 2011;12(3):330-48.
2011: Brit-Maren M Schjeide; Cathrin Schnack; Jean-Charles Lambert; Christina M Lill; Julia Kirchheiner; Hayrettin Tumani; Markus Otto; Rudolph E Tanzi; Hans Lehrach; Philippe Amouyel; Christine A F Von Arnim; Lars Bertram
The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels.
Archives of general psychiatry 2011;68(2):207-13.
2011: Yiying Zhang; Yu Zhen; Zhipeng Xu; Yun Yue; Yuanlin Dong; todd golde; Robert D Moir; Rudolph E Tanzi; Zhongcong Xie
Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization.
PloS one 2011;6(11):e27019.
2011: Rebekah C Mannix; Jimmy Zhang; Juyeon Park; Xuan Zhang; Kiran Bilal; Kendall Walker; Rudolph E Tanzi; Giuseppina Tesco; Michael J Whalen
Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011;31(1):351-61.
2010: Eric M Norstrom; Can Zhang; Rudolph E Tanzi; Sangram S Sisodia
Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(46):15677-85.
2010: Lars Bertram; Christina M Lill; Rudolph E Tanzi
The genetics of Alzheimer disease: back to the future.
Neuron 2010;68(2):270-81.
2010: Rachel Frances Lane; Summer M Raines; John W Steele; Michelle E Ehrlich; James A Lah; Scott A Small; Rudolph E Tanzi; Alan D Attie; Sam Gandy
Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(39):13110-5.
2010: James A Duce; Andrew Tsatsanis; Michael A Cater; Simon A James; Elysia Robb; Krutika Wikhe; Su Ling Leong; Keyla Perez; Timothy Johanssen; Mark A Greenough; Hyun-Hee Cho; Denise Galatis; Robert D. Moir; Colin L Masters; Catriona McLean; Rudolph E Tanzi; Roberto Cappai; Kevin J Barnham; Giuseppe D Ciccotosto; Jack T Rogers; Ashley I Bush
Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.
Cell 2010;142(6):857-67.
2010: Can Zhang; Andrew Browne; Daniel Child; Rudolph E Tanzi
Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.
The Journal of biological chemistry 2010;285(37):28472-80.
2010: Maria Z Kounnas; Anne M Danks; Soan Cheng; Curtis Tyree; Elizabeth Ackerman; Xulun Zhang; Kwangwook Ahn; Phuong Nguyen; Dan Comer; Long Mao; Chengzhi Yu; David Pleynet; Paul J Digregorio; Gonul Velicelebi; Kenneth A Stauderman; William T Comer; William C Mobley; Yue-Ming Li; Sangram S Sisodia; Rudolph E Tanzi; Steven L Wagner
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Neuron 2010;67(5):769-80.
2010: Jaehong Suh; Doo Soon Im; Gyeong Joon Moon; Keun Sil Ryu; Rohan de Silva; In Sun Choi; Andrew J Lees; Suzanne Y Guénette; Rudolph E Tanzi; Byoung Joo Gwag
Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing.
Journal of neurochemistry 2010;114(1):160-70.
2010: Christina M Lill; Brit-Maren M Schjeide; Johannes T Roehr; Ute Zauft; Nicole C Allen; Frauke Zipp; Matthew B McQueen; Fotini K Kavvoura; John Ioannidis; Muin J Khoury; Rudolph E Tanzi; Lars Bertram
Correspondence to Sand et Al. "Critical reappraisal of a catechol-o-methyltransferase transversion variant in schizophrenia".
Biological psychiatry 2010;67(7):e45-8.
2010: Can Zhang; Andrew Browne; Daniel Child; Jason R Divito; Jesse A Stevenson; Rudolph E Tanzi
Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein.
The Journal of biological chemistry 2010;285(12):8515-26.
2010: Davide Gianni; Airong Li; Giuseppina Tesco; Kenneth M McKay; John Moore; Kunal Raygor; Marcello Rota; Judith K Gwathmey; G William Dec; Thomas Aretz; Annarosa Leri; Marc J Semigran; Piero Anversa; Thomas E Macgillivray; Rudolph E Tanzi; Federica del Monte
Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy.
Circulation 2010;121(10):1216-26.
2010: Can Zhang; Andrew Browne; Doo Yeon Kim; Rudolph E Tanzi
Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage.
Current Alzheimer research 2010;7(1):21-6.
2010: Annakaisa Haapasalo; Jayashree Viswanathan; Lars Bertram; Hilkka Soininen; Rudolph E Tanzi; Mikko Hiltunen
Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation.
Biochemical Society transactions 2010;38(Pt 1):150-5.
2010: Vilmantas Giedraitis; Anna Glaser; Timo Sarajärvi; RoseMarie Brundin; Malin Degerman Gunnarsson; Brit-Maren Schjeide; Rudolph E Tanzi; Seppo Helisalmi; Tuula Pirttilä; Lena Kilander; Lars Lannfelt; Hilkka Soininen; Lars Bertram; Martin Ingelsson; Mikko Hiltunen
CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid.
Neuroscience letters 2010;469(2):265-7.
2010: Can Zhang; Andrew Browne; Jason R Divito; Jesse A Stevenson; Donna Romano; Yuanlin Dong; Zhongcong Xie; Rudolph E Tanzi
Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density.
Journal of Alzheimer's disease : JAD 2010;22(2):683-984.
2010: Jean-Charles Lambert; Kristel Sleegers; Antonio González-Pérez; Martin Ingelsson; Gary Beecham; Mikko Hiltunen; Onofre Combarros; Maria J Bullido; Nathalie Brouwers; Karolien Bettens; Claudine Berr; Florence Pasquier; Florence Richard; Steven T DeKosky; Didier Hannequin; Jonathan L Haines; Gloria Tognoni; Nathalie Fiévet; Jean-François Dartigues; Christophe Tzourio; Sebastiaan Engelborghs; Beatrice Arosio; Elicer Coto; Peter De Deyn; Maria Del Zompo; Ignacio Mateo; Merce Boada; Carmen Antunez; Jesus Lopez-Arrieta; Jacques Epelbaum; Brit-Maren Michaud Schjeide; Ana Frank-Garcia; Vilmentas Giedraitis; Seppo Helisalmi; Elisa Porcellini; Alberto Pilotto; Paola Forti; Raffaele Ferri; Marc Delepine; Diana Zelenika; Mark Lathrop; Elio Scarpini; Gabriele Siciliano; Vincenzo Solfrizzi; Sandro Sorbi; Gianfranco Spalletta; Giovanni Ravaglia; Fernando Valdivieso; Saila Vepsäläinen; Victoria Alvarez; Paolo Bosco; Michelangelo Mancuso; Francesco Panza; Benedetta Nacmias; Paola Bossù; Olivier Hanon; Paola Piccardi; Giorgio Annoni; David Mann; Philippe Marambaud; Davide Seripa; Daniela Galimberti; Rudolph E Tanzi; Lars Bertram; Corinne Lendon; Lars Lannfelt; Federico Licastro; Dominique Campion; Margaret Pericak-Vance; Hilkka Soininen; Christine Van Broeckhoven; Annick Alpérovitch; Agustin Ruiz; M Ilyas Kamboh; Philippe Amouyel
The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study.
Journal of Alzheimer's disease : JAD 2010;22(1):247-55.
2010: Juliet A Moncaster; Roberto Pineda; Robert D Moir; Suqian Lu; Mark A Burton; Joy G Ghosh; Maria Ericsson; Stephanie J Soscia; Anca Mocofanescu; Rebecca D Folkerth; Richard M Robb; Jer R Kuszak; John I Clark; Rudolph E Tanzi; David G Hunter; Lee E Goldstein
Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome.
PloS one 2010;5(5):e10659.
2010: Stephanie J Soscia; James E Kirby; Kevin J Washicosky; Stephanie M Tucker; Martin Ingelsson; Bradley T Hyman; Mark A Burton; Lee E Goldstein; Scott Duong; Rudolph E Tanzi; Robert D Moir
The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.
PloS one 2010;5(3):e9505.
2010: Noel G Faux; Craig W Ritchie; Adam Gunn; Alan Rembach; Andrew Tsatsanis; Justin Bedo; John Edward Harrison; Lars Lannfelt; Kaj Blennow; Henrik Zetterberg; Martin Ingelsson; Colin L Masters; Rudolph E Tanzi; Jeffrey L Cummings; Caroline M Herd; Ashley I Bush
PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses.
Journal of Alzheimer's disease : JAD 2010;20(2):509-16.
2010: Lars Bertram; Rudolph E Tanzi
Alzheimer disease: New light on an old CLU.
Nature reviews. Neurology 2010;6(1):11-3.
2010: Maija Pihlajamäki; Kelly O' Keefe; Lars Bertram; Rudolph E Tanzi; Bradford C Dickerson; Deborah Blacker; Marilyn S Albert; Reisa Sperling
Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer disease.
Alzheimer disease and associated disorders 2010;24(1):28-36.
2009: David Fardo; K David Becker; Lars Bertram; Rudolph E Tanzi; Christoph Lange
Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium.
European journal of human genetics : EJHG 2009;17(12):1676-82.
2009: Lars Bertram; Rudolph E Tanzi
Genome-wide association studies in Alzheimer's disease.
Human molecular genetics 2009;18(R2):R137-45.
2009: Minji Kim; Jaehong Suh; Donna M Romano; Mimy H Truong; Kristina Mullin; Basavaraj Hooli; David Norton; Giuseppina Tesco; Kathy Elliott; Steven L Wagner; Robert D. Moir; K David Becker; Rudolph E Tanzi
Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.
Human molecular genetics 2009;18(20):3987-96.
2009: Yuanlin Dong; Guohua Zhang; Bin Zhang; Robert D. Moir; Weiming Xia; Edward R Marcantonio; Deborah J Culley; Gregory Crosby; Rudolph E Tanzi; Zhongcong Xie
The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels.
Archives of neurology 2009;66(5):620-31.
2009: Alice Lu; Mikko Hiltunen; Donna M Romano; Hilkka Soininen; Bradley T Hyman; Lars Bertram; Rudolph E Tanzi
Effects of ubiquilin 1 on the unfolded protein response.
Journal of molecular neuroscience : MN 2009;38(1):19-30.
2009: Michael A Myre; Kevin Washicosky; Robert D. Moir; Giuseppina Tesco; Rudolph E Tanzi; Wilma Wasco
Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.
Cellular signalling 2009;21(4):567-76.
2009: Brit-Maren M Schjeide; Basavaraj Hooli; Michele Parkinson; Meghan F Hogan; Jason DiVito; Kristina Mullin; Deborah Blacker; Rudolph E Tanzi; Lars Bertram
GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results.
Archives of neurology 2009;66(2):250-4.
2009: Brit-Maren M Schjeide; Matthew B McQueen; Kristina Mullin; Jason DiVito; Meghan F Hogan; Michele Parkinson; Basavaraj Hooli; Christoph Lange; Deborah Blacker; Rudolph E Tanzi; Lars Bertram
Assessment of Alzheimer's disease case-control associations using family-based methods.
Neurogenetics 2009;10(1):19-25.
2009: Basavaraj V Hooli; Rudolph E Tanzi
A current view of Alzheimer's disease.
F1000 biology reports 2009;1():54.
2008: Lars Bertram; Brit-Maren M Schjeide; Basavaraj Hooli; Kristina Mullin; Mikko Hiltunen; Hilkka Soininen; Martin Ingelsson; Lars Lannfelt; Deborah Blacker; Rudolph E Tanzi
No association between CALHM1 and Alzheimer's disease risk.
Cell 2008;135(6):993-4; author reply 994-6.
2008: Zhongcong Xie; Deborah J Culley; Yuanlin Dong; Guohua Zhang; Bin Zhang; Robert D. Moir; Matthew P Frosch; Gregory Crosby; Rudolph E Tanzi
The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo.
Annals of neurology 2008;64(6):618-27.
2008: Richard G H Cotton; Arleen D Auerbach; Myles Axton; Carol Isaacson Barash; Samuel F Berkovic; Anthony J Brookes; John Burn; Garry R Cutting; Johan T den Dunnen; Paul Flicek; Nelson Freimer; Marc S Greenblatt; Heather J Howard; Michael Katz; Finlay A Macrae; Donna Maglott; Gabriela Möslein; Sue Povey; Rajkumar S Ramesar; Carolyn S (Sue) Richards; Daniela Seminara; Timothy D Smith; María-Jesús Sobrido; Jan Helge Solbakk; Rudolph E Tanzi; Sean V Tavtigian; Graham Taylor; Joji Utsunomiya; Michael Watson
GENETICS. The Human Variome Project.
Science (New York, N.Y.) 2008;322(5903):861-2.
2008: Lars Bertram; Christoph Lange; Kristina Mullin; Michele Parkinson; Monica Hsiao; Meghan F Hogan; Brit M M Schjeide; Basavaraj Hooli; Jason Divito; Iuliana Ionita; Hongyu Jiang; Nan M Laird; Thomas Moscarillo; Kari L Ohlsen; Kathryn Elliott; Xin Wang; Diane Hu-Lince; Marie Ryder; Amy Murphy; Steven L Wagner; Deborah Blacker; K David Becker; Rudolph E Tanzi
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.
American journal of human genetics 2008;83(5):623-32.
2008: Fotini K Kavvoura; Matthew B McQueen; Muin J Khoury; Rudolph E Tanzi; Lars Bertram; John Ioannidis
Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease.
American journal of epidemiology 2008;168(8):855-65.
2008: Barbara A J Schaffer; Lars Bertram; Bruce L Miller; Kristina Mullin; Sandra Weintraub; Nancy Johnson; Eileen H Bigio; Marek-Marsel Mesulam; Martina Wiedau-Pazos; George R Jackson; Jeffrey L Cummings; Rita M Cantor; Allan Levey; Rudolph E Tanzi; Daniel Geschwind
Association of GSK3B with Alzheimer disease and frontotemporal dementia.
Archives of neurology 2008;65(10):1368-74.
2008: In Ho Lee; Deborah J Culley; Mark G Baxter; Zhongcong Xie; Rudolph E Tanzi; Gregory Crosby
Spatial memory is intact in aged rats after propofol anesthesia.
Anesthesia and analgesia 2008;107(4):1211-5.
2008: Lars Bertram; Rudolph E Tanzi
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses.
Nature reviews. Neuroscience 2008;9(10):768-78.
2008: Rudolph E Tanzi; Lars Bertram
Alzheimer's disease: The latest suspect.
Nature 2008;454(7205):706-8.
2008: Paul A Adlard; Robert A Cherny; David Finkelstein; Elisabeth Gautier; Elysia Robb; Mikhalina Cortes; Irene Volitakis; Xiang Liu; Jeffrey P Smith; Keyla Perez; Katrina Laughton; Qiao-Xin Li; Susan A Charman; Joseph A Nicolazzo; Simon Wilkins; Karolina Deleva; Toni Lynch; Gaik Kok; Craig W Ritchie; Rudolph E Tanzi; Roberto Cappai; Colin L Masters; Kevin J Barnham; Ashley I Bush
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.
Neuron 2008;59(1):43-55.
2008: Ashley I Bush; Rudolph E Tanzi
Therapeutics for Alzheimer's disease based on the metal hypothesis.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2008;5(3):421-32.
2008: Rudolph E Tanzi
Novel therapeutics for Alzheimer's disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2008;5(3):377-80.
2008: Nicole C Allen; Sachin Bagade; Matthew B McQueen; John Ioannidis; Fotini K Kavvoura; Muin J Khoury; Rudolph E Tanzi; Lars Bertram
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
Nature genetics 2008;40(7):827-34.
2008: Bin Zhang; Yuanlin Dong; Guohua Zhang; Robert D. Moir; Weiming Xia; Yun Yue; Ming Tian; Deborah J Culley; Gregory Crosby; Rudolph E Tanzi; Zhongcong Xie
The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions.
The Journal of biological chemistry 2008;283(18):11866-75.
2008: Guohua Zhang; Yuanlin Dong; Bin Zhang; Fumito Ichinose; Xu Wu; Deborah J Culley; Gregory Crosby; Rudolph E Tanzi; Zhongcong Xie
Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(17):4551-60.
2008: Lauren A Weiss; Yiping Shen; Joshua M Korn; Dan E Arking; David T Miller; Ragnheidur Fossdal; Evald Saemundsen; Hreinn Stefansson; Manuel A R Ferreira; Todd Green; Orah S Platt; Douglas M Ruderfer; Christopher Walsh; David Altshuler; Aravinda Chakravarti; Rudolph E Tanzi; Kari Stefansson; Susan L Santangelo; James Gusella; Pamela Sklar; Bai-Lin Wu; Mark J Daly
Association between microdeletion and microduplication at 16p11.2 and autism.
The New England journal of medicine 2008;358(7):667-75.
2008: Eric E Smith; Svetlana Egorova; Deborah Blacker; Ronald J Killiany; Alona Muzikansky; Bradford C Dickerson; Rudolph E Tanzi; Marilyn S Albert; Steven M Greenberg; Charles R G Guttmann
Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia.
Archives of neurology 2008;65(1):94-100.
2007: Matthew B McQueen; Lars Bertram; Christoph Lange; K David Becker; Marilyn S Albert; Rudolph E Tanzi; Deborah Blacker
Exploring candidate gene associations with neuropsychological performance.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(8):987-91.
2007: Marian Hamshere; Peter Holmans; Dimitrios Avramopoulos; Susan S Bassett; Deborah Blacker; Lars Bertram; Howard Wiener; Nan Rochberg; Rudolph E Tanzi; Amanda Myers; Fabienne Wavrant-De Vrièze; Rodney Go; Daniele Fallin; Simon Lovestone; John Hardy; Alison Goate; Michael O'Donovan; Julie Williams; Michael J Owen
Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease.
Human molecular genetics 2007;16(22):2703-12.
2007: Airong Li; Zhongcong Xie; Yuanlin Dong; Kenneth M McKay; Mary L McKee; Rudolph E Tanzi
Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes.
Human molecular genetics 2007;16(21):2626-39.
2007: Henri Huttunen; Suzanne Y Guénette; Camilla Peach; Christopher Greco; Weiming Xia; Doo Yeon Kim; Cory Barren; Rudolph E Tanzi; Dora M. Kovacs
HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation.
The Journal of biological chemistry 2007;282(38):28285-95.
2007: Saila Vepsäläinen; Michele Parkinson; Seppo Helisalmi; Arto Mannermaa; Hilkka Soininen; Rudolph E Tanzi; Lars Bertram; Mikko Hiltunen
Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population.
Journal of medical genetics 2007;44(9):606-8.
2007: Giuseppina Tesco; Young Ho Koh; Eugene L Kang; Andrew N Cameron; Shinjita Das; Miguel Sena-Esteves; Mikko Hiltunen; Shao-Hua Yang; Zhenyu Zhong; Yong Shen; James W Simpkins; Rudolph E Tanzi
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity.
Neuron 2007;54(5):721-37.
2007: Deborah Blacker; Hang Lee; Alona Muzikansky; Emily C Martin; Rudolph E Tanzi; John J McArdle; Mark Moss; Marilyn S Albert
Neuropsychological measures in normal individuals that predict subsequent cognitive decline.
Archives of neurology 2007;64(6):862-71.
2007: Minji Kim; Louis B Hersh; Malcolm Leissring; Martin Ingelsson; Toshifumi Matsui; Wesley Farris; Alice Lu; Bradley T Hyman; Dennis J Selkoe; Lars Bertram; Rudolph E Tanzi
Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.
The Journal of biological chemistry 2007;282(11):7825-32.
2007: Rodney T Perry; Howard Wiener; Lindy E Harrell; Deborah Blacker; Rudolph E Tanzi; Lars Bertram; Susan S Bassett; Rodney C P Go
Follow-up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease Genetics Initiative cohort.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(2):220-7.
2007: Marilyn S Albert; Deborah Blacker; Mark B Moss; Rudolph E Tanzi; John J McArdle
Longitudinal change in cognitive performance among individuals with mild cognitive impairment.
Neuropsychology 2007;21(2):158-69.
2007: Avi Friedlich; Rudolph E Tanzi; Jack T Rogers
The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element.
Molecular psychiatry 2007;12(3):222-3.
2007: Peter Szatmari; Andrew D Paterson; Lonnie Zwaigenbaum; Wendy Roberts; Jessica Brian; Xiao-Qing Liu; John B Vincent; Jennifer L Skaug; Ann P Thompson; Lili Senman; Lars Feuk; Cheng Qian; Susan E Bryson; Marshall B Jones; Christian R Marshall; Stephen W Scherer; Veronica J Vieland; Christopher Bartlett; La Vonne Mangin; Rhinda Goedken; Alberto Segre; Margaret Pericak-Vance; Michael Cuccaro; John Gilbert; Harry H Wright; Ruth K Abramson; Catalina Betancur; Thomas Bourgeron; Christopher Gillberg; Marion Leboyer; Joseph Buxbaum; Kenneth L Davis; Eric Hollander; Jeremy Silverman; Joachim Hallmayer; Linda Lotspeich; James S Sutcliffe; Jonathan L Haines; Susan E Folstein; Joseph Piven; Thomas H Wassink; Val Sheffield; Daniel Geschwind; Maja Bucan; W Ted Brown; Rita M Cantor; John N Constantino; T Conrad Gilliam; Martha Herbert; Clara Lajonchere; David Ledbetter; Christa Lese Martin; Janet Miller; Stan Nelson; Carol A Samango-Sprouse; Sarah J Spence; Sate Matthew; Rudolph E Tanzi; Hilary Coon; Geraldine Dawson; Bernie Devlin; Annette Estes; Pamela Flodman; Lambertus Klei; William M McMahon; Nancy J Minshew; Jeffrey Munson; Elena Korvatska; Patricia M Rodier; Gerard D Schellenberg; Moyra Smith; M Anne Spence; Chris Stodgell; Ping Guo Tepper; Ellen M Wijsman; Chang-En Yu; Bernadette Rogé; Carine Mantoulan; Kerstin Wittemeyer; Annemarie Poustka; Bärbel Felder; Sabine M Klauck; Claudia Schuster; Fritz Poustka; Sven Bölte; Sabine Feineis-Matthews; Evelyn Herbrecht; Gabi Schmötzer; John Tsiantis; Katerina Papanikolaou; Elena Maestrini; Elena Bacchelli; Francesca Blasi; Simona Carone; Claudio Toma; Herman Van Engeland; Maretha de Jonge; Chantal Kemner; Frederieke Koop; Frederike Koop; Marjolein Langemeijer; Marjolijn Langemeijer; Channa Hijmans; Channa Hijimans; Wouter G Staal; Gillian Baird; Patrick Bolton; Michael L Rutter; Emma Weisblatt; Jonathan Green; Catherine Aldred; Julie-Anne Wilkinson; Andrew Pickles; Ann Le Couteur; Tom Berney; Helen McConachie; Anthony J Bailey; Kostas Francis; Gemma Honeyman; Aislinn Hutchinson; Jeremy R Parr; Simon Wallace; Anthony P Monaco; Gabrielle Barnby; Kazuhiro Kobayashi; Janine A Lamb; Ines Sousa; Nuala Sykes; Edwin H Cook; Stephen J Guter; Bennett L Leventhal; Jeff Salt; Catherine Lord; Christina Corsello; Vanessa Hus; Daniel E Weeks; Fred Volkmar; Maïté Tauber; Eric Fombonne; Andy Shih; Kacie J Meyer
Mapping autism risk loci using genetic linkage and chromosomal rearrangements.
Nature genetics 2007;39(3):319-28.
2007: Zhongcong Xie; Yuanlin Dong; Uta Maeda; Weiming Xia; Rudolph E Tanzi
RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation.
The Journal of biological chemistry 2007;282(7):4318-25.
2007: Zhongcong Xie; Yuanlin Dong; Uta Maeda; Robert D. Moir; Weiming Xia; Deborah J Culley; Gregory Crosby; Rudolph E Tanzi
The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(6):1247-54.
2007: Can Zhang; Preeti J Khandelwal; Ranjita Chakraborty; Trinna L Cuellar; Srikant Sarangi; Shyam A Patel; Christopher P Cosentino; Michael O'Connor; Jeremy C Lee; Rudolph E Tanzi; Aleister J Saunders
An AICD-based functional screen to identify APP metabolism regulators.
Molecular neurodegeneration 2007;2():15.
2007: Lars Bertram; Kristina Mullin; Michele Parkinson; Monica Hsiao; Thomas J Moscarillo; Steven L Wagner; K David Becker; Gonul Velicelebi; Deborah Blacker; Rudolph E Tanzi
Is alpha-T catenin (VR22) an Alzheimer's disease risk gene?
Journal of medical genetics 2007;44(1):e63.
2007: Lars Bertram; Matthew B McQueen; Kristina Mullin; Deborah Blacker; Rudolph E Tanzi
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.
Nature genetics 2007;39(1):17-23.
2007: Lars Bertram; Monica Hsiao; Matthew B McQueen; Michele Parkinson; Kristina Mullin; Deborah Blacker; Rudolph E Tanzi
The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data.
Neurobiology of aging 2007;28(1):18.e1-4.
2006: Zhongcong Xie; Yuanlin Dong; Uta Maeda; Robert D. Moir; Sharon K Inouye; Deborah J Culley; Gregory Crosby; Rudolph E Tanzi
Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia.
The journals of gerontology. Series A, Biological sciences and medical sciences 2006;61(12):1300-6.
2006: Deborah J Culley; Rustam Yukhananov; Zhongcong Xie; Reddy R Gali; Rudolph E Tanzi; Gregory Crosby
Altered hippocampal gene expression 2 days after general anesthesia in rats.
European journal of pharmacology 2006;549(1-3):71-8.
2006: Mikko Hiltunen; Alice Lu; Anne V Thomas; Donna M Romano; Minji Kim; Phill B Jones; Zhongcong Xie; Maria Z Kounnas; Steven L Wagner; Oksana Berezovska; Bradley T Hyman; Giuseppina Tesco; Lars Bertram; Rudolph E Tanzi
Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.
The Journal of biological chemistry 2006;281(43):32240-53.
2006: Anne V Thomas; Lauren Herl; Robert Spoelgen; Mikko Hiltunen; Phill B Jones; Rudolph E Tanzi; Bradley T Hyman; Oksana Berezovska
Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader.
The Journal of biological chemistry 2006;281(36):26400-7.
2006: Lars Bertram; Monica Hsiao; Christoph Lange; Deborah Blacker; Rudolph E Tanzi
Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples.
American journal of human genetics 2006;79(1):180-3; author reply 183-4.
2006: Guijian Liu; Weidong Huang; Robert D. Moir; Charles R Vanderburg; Barry Lai; Zicheng Peng; Rudolph E Tanzi; Jack T Rogers; Xudong Huang
Metal exposure and Alzheimer's pathogenesis.
Journal of structural biology 2006;155(1):45-51.
2006: Donna M Romano; Yuanlin Dong; Mikko Hiltunen; Rudolph E Tanzi; Zhongcong Xie
Artefactual effects of lipid-based cell transfection reagents on AbetaPP processing and Abeta production.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2006;13(2):86-92.
2006: Zhongcong Xie; Yuanlin Dong; Uta Maeda; Paul Alfille; Deborah J Culley; Gregory Crosby; Rudolph E Tanzi
The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels.
Anesthesiology 2006;104(5):988-94.
2006: Zhongcong Xie; Rudolph E Tanzi
Alzheimer's disease and post-operative cognitive dysfunction.
Experimental gerontology 2006;41(4):346-59.
2005: Lars Bertram; Michele Parkinson; Matthew B McQueen; Kristina Mullin; Monica Hsiao; Rashmi Menon; Thomas J Moscarillo; Deborah Blacker; Rudolph E Tanzi
Further evidence for LBP-1c/CP2/LSF association in Alzheimer's disease families.
Journal of medical genetics 2005;42(11):857-62.
2005: Rudolph E Tanzi
Tangles and neurodegenerative disease--a surprising twist.
The New England journal of medicine 2005;353(17):1853-5.
2005: Giuseppina Tesco; Andrea Ginestroni; Mikko Hiltunen; Minji Kim; Georgia Dolios; Bradley T Hyman; Rong Wang; Oksana Berezovska; Rudolph E Tanzi
APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation.
Journal of neurochemistry 2005;95(2):446-56.
2005: Young Ho Koh; Christine A F Von Arnim; Bradley T Hyman; Rudolph E Tanzi; Giuseppina Tesco
BACE is degraded via the lysosomal pathway.
The Journal of biological chemistry 2005;280(37):32499-504.
2005: Bradford C Dickerson; David H Salat; Douglas N Greve; Elizabeth F Chua; Erin Rand-Giovannetti; Dorene M Rentz; Lars Bertram; Kristina Mullin; Rudolph E Tanzi; Deborah Blacker; Marilyn S Albert; Reisa Sperling
Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD.
Neurology 2005;65(3):404-11.
2005: Rudolph E Tanzi
The synaptic Abeta hypothesis of Alzheimer disease.
Nature neuroscience 2005;8(8):977-9.
2005: Lars Bertram; Rudolph E Tanzi
The genetic epidemiology of neurodegenerative disease.
The Journal of clinical investigation 2005;115(6):1449-57.
2005: Lars Bertram; M Hsiao; Kristina Mullin; M Parkinson; R Menon; Thomas J Moscarillo; Deborah Blacker; Rudolph E Tanzi
ACAT1 is not associated with Alzheimer's disease in two independent family-based samples.
Molecular psychiatry 2005;10(6):522-4.
2005: Robert D. Moir; Katya A Tseitlin; Stephanie Soscia; Bradley T Hyman; Michael C Irizarry; Rudolph E Tanzi
Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients.
The Journal of biological chemistry 2005;280(17):17458-63.
2005: Zhongcong Xie; Donna M Romano; Rudolph E Tanzi
RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing.
The Journal of biological chemistry 2005;280(15):15413-21.
2005: Robert D. Moir; Rudolph E Tanzi
LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP.
Current Alzheimer research 2005;2(2):269-73.
2005: Lars Bertram; Mikko Hiltunen; Michele Parkinson; Martin Ingelsson; Christoph Lange; Karunya Ramasamy; Kristina Mullin; Rashmi Menon; Andrew J Sampson; Monica Hsiao; Kathryn J Elliott; Gonul Velicelebi; Thomas J Moscarillo; Bradley T Hyman; Steven L Wagner; K David Becker; Deborah Blacker; Rudolph E Tanzi
Family-based association between Alzheimer's disease and variants in UBQLN1.
The New England journal of medicine 2005;352(9):884-94.
2005: Rudolph E Tanzi; Lars Bertram
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective.
Cell 2005;120(4):545-55.
2005: Zhongcong Xie; Donna M Romano; Rudolph E Tanzi
Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1.
Journal of molecular neuroscience : MN 2005;25(1):67-77.
2004: Xudong Huang; Craig S Atwood; Robert D. Moir; Mariana A Hartshorn; Rudolph E Tanzi; Ashley I Bush
Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(8):954-60.
2004: Alpaslan Dedeoglu; Kerry Cormier; Sandra M Payton; Katya A Tseitlin; Jonathan N Kremsky; Li Lai; Xiaohua Li; Robert D. Moir; Rudolph E Tanzi; Ashley I Bush; Neil W Kowall; Jack T Rogers; Xudong Huang
Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis.
Experimental gerontology 2004;39(11-12):1641-9.
2004: Lars Bertram; Rudolph E Tanzi
The current status of Alzheimer's disease genetics: what do we tell the patients?
Pharmacological research : the official journal of the Italian Pharmacological Society 2004;50(4):385-96.
2004: Rudolph E Tanzi; Robert D. Moir; Steven L Wagner
Clearance of Alzheimer's Abeta peptide: the many roads to perdition.
Neuron 2004;43(5):605-8.
2004: Zhongcong Xie; Donna M Romano; Dora M. Kovacs; Rudolph E Tanzi
Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation.
The Journal of biological chemistry 2004;279(33):34130-7.
2004: Seiichi Nagano; Xudong Huang; Robert D. Moir; Sandra M Payton; Rudolph E Tanzi; Ashley I Bush
Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease.
The Journal of biological chemistry 2004;279(15):14673-8.
2004: Lars Bertram; Michele Parkinson; Kristina Mullin; Rashmi Menon; Deborah Blacker; Rudolph E Tanzi
No association between a previously reported OLR1 3' UTR polymorphism and Alzheimer's disease in a large family sample.
Journal of medical genetics 2004;41(4):286-8.
2004: Wesley Farris; Stefan Mansourian; Malcolm Leissring; Elizabeth A Eckman; Lars Bertram; Christopher B Eckman; Rudolph E Tanzi; Dennis J Selkoe
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.
The American journal of pathology 2004;164(4):1425-34.
2004: Lars Bertram; Rudolph E Tanzi
Alzheimer's disease: one disorder, too many genes?
Human molecular genetics 2004;13 Spec No 1():R135-41.
2004: Xudong Huang; Robert D. Moir; Rudolph E Tanzi; Ashley I Bush; Jack T Rogers
Redox-active metals, oxidative stress, and Alzheimer's disease pathology.
Annals of the New York Academy of Sciences 2004;1012():153-63.
2004: Lars Bertram; Rashmi Menon; Kristina Mullin; Michele Parkinson; M L Bradley; Deborah Blacker; Rudolph E Tanzi
PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample.
Neurology 2004;62(2):304-6.
2004: Zhongcong Xie; Robert D. Moir; Donna M Romano; Giuseppina Tesco; Dora M. Kovacs; Rudolph E Tanzi
Hypocapnia induces caspase-3 activation and increases Abeta production.
Neuro-degenerative diseases 2004;1(1):29-37.
2003: Yang Chang; Giuseppina Tesco; William J Jeong; Loren Lindsley; Elizabeth A Eckman; Christopher B Eckman; Rudolph E Tanzi; Suzanne Y Guénette
Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.
The Journal of biological chemistry 2003;278(51):51100-7.
2003: Craig W Ritchie; Ashley I Bush; Andrew Mackinnon; Stephen Macfarlane; Maree Mastwyk; Lachlan MacGregor; Lyn Kiers; Robert A Cherny; Qiao-Xin Li; Amanda Tammer; Darryl Carrington; Christine Mavros; Irene Volitakis; Michel E Xilinas; David Ames; Stephen Davis; Konrad Beyreuther; Rudolph E Tanzi; Colin L Masters
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.
Archives of neurology 2003;60(12):1685-91.
2003: Giuseppina Tesco; Young Ho Koh; Rudolph E Tanzi
Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP).
The Journal of biological chemistry 2003;278(46):46074-80.
2003: Aleister J Saunders; Rudolph E Tanzi
Welcome to the complex disease world. Alpha2-macroglobulin and Alzheimer's disease.
Experimental neurology 2003;184(1):50-3.
2003: Aleister J Saunders; Lars Bertram; Kristina Mullin; Andrew J Sampson; Khushal Latifzai; Sanjay Basu; Jennifer Jones; Devon Kinney; Laura MacKenzie-Ingano; Stephen Yu; Marilyn S Albert; Thomas J Moscarillo; Rodney C P Go; Susan S Bassett; Mark J Daly; Nan M Laird; Xin Wang; Gonul Velicelebi; Steven L Wagner; David K Becker; Rudolph E Tanzi; Deborah Blacker
Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin.
Human molecular genetics 2003;12(21):2765-76.
2003: Ashley I Bush; Colin L Masters; Rudolph E Tanzi
Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11193-4.
2003: Lars Bertram; Aleister J Saunders; Kristina Mullin; A Sampson; Thomas J Moscarillo; S S Basset; Rodney C P Go; Deborah Blacker; Rudolph E Tanzi
No association between marker D10S1423 and Alzheimer's disease.
Molecular psychiatry 2003;8(6):571-3.
2003: Lee E Goldstein; Julien A Muffat; Robert A Cherny; Robert D. Moir; Maria H Ericsson; Xudong Huang; Christine Mavros; Jennifer A Coccia; Kyle Y Faget; Karlotta A Fitch; Colin L Masters; Rudolph E Tanzi; Leo T Chylack; Ashley I Bush
Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease.
Lancet 2003;361(9365):1258-65.
2003: Luigi Puglielli; Rudolph E Tanzi; Dora M. Kovacs
Alzheimer's disease: the cholesterol connection.
Nature neuroscience 2003;6(4):345-51.
2003: Wesley Farris; Stefan Mansourian; Yang Chang; Loren Lindsley; Elizabeth A Eckman; Matthew P Frosch; Christopher B Eckman; Rudolph E Tanzi; Dennis J Selkoe; Suzanne Guenette
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4162-7.
2003: Deborah Blacker; Lars Bertram; Aleister J Saunders; Thomas J Moscarillo; Marilyn S Albert; Howard Wiener; Rodney T Perry; Julianne Collins; Lindy E Harrell; Rodney C P Go; Amy Mahoney; Terri H beaty; MARGARET D FALLIN; Dimitrios Avramopoulos; Gary A Chase; MARSHAL FOLSTEIN; Melvin G McInnis; Susan S Bassett; Kimberly J Doheny; Elizabeth W Pugh; Rudolph E Tanzi
Results of a high-resolution genome screen of 437 Alzheimer's disease families.
Human molecular genetics 2003;12(1):23-32.
2002: Jack T Rogers; Jeffrey D Randall; Catherine M Cahill; Paul S Eder; Xudong Huang; Hiromi Gunshin; Lorene Leiter; Jay McPhee; Satinder S Sarang; Tada Utsuki; Nigel H Greig; Debomoy K Lahiri; Rudolph E Tanzi; Ashley I Bush; Tony Giordano; Steven R Gullans
An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript.
The Journal of biological chemistry 2002;277(47):45518-28.
2002: Carlos Opazo; Xudong Huang; Robert A Cherny; Robert D. Moir; Alex Roher; Anthony R White; Roberto Cappai; Colin L Masters; Rudolph E Tanzi; Nibaldo C Inestrosa; Ashley I Bush
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
The Journal of biological chemistry 2002;277(43):40302-8.
2002: Suzanne Y Guénette; Yang Chang; Bradley T Hyman; Rudolph E Tanzi; G. William Rebeck
Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1.
Journal of neurochemistry 2002;82(4):755-62.
2002: Jack T Rogers; Jeffrey D Randall; Paul S Eder; Xudong Huang; Ashley I Bush; Rudolph E Tanzi; Amanda Venti; Sandra M Payton; Tony Giordano; Seiichi Nagano; Catherine M Cahill; Robert D. Moir; Debomoy K Lahiri; Nigel H Greig; Satinder S Sarang; Steven R Gullans
Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region.
Journal of molecular neuroscience : MN 2002;19(1-2):77-82.
2002: Joy J Goto; Rudolph E Tanzi
The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system.
Journal of molecular neuroscience : MN 2002;19(1-2):37-41.
2002: Ashley I Bush; Rudolph E Tanzi
The galvanization of beta-amyloid in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7317-9.
2002: Ronald J Killiany; Bradley T Hyman; T Gomez-Isla; Mark B Moss; R Kikinis; Ferenc A Jolesz; Rudolph E Tanzi; K Jones; Marilyn S Albert
MRI measures of entorhinal cortex vs hippocampus in preclinical AD.
Neurology 2002;58(8):1188-96.
2001: Rudolph E Tanzi; Lars Bertram
New frontiers in Alzheimer's disease genetics.
Neuron 2001;32(2):181-4.
2001: Lars Bertram; Rudolph E Tanzi
Dancing in the dark? The status of late-onset Alzheimer's disease genetics.
Journal of molecular neuroscience : MN 2001;17(2):127-36.
2001: Luigi Puglielli; Genevieve Konopka; E Pack-Chung; Laura A Mackenzie Ingano; Oksana Berezovska; Bradley T Hyman; T Y Chang; Rudolph E Tanzi; Dora M. Kovacs
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide.
Nature cell biology 2001;3(10):905-12.
2001: Lars Bertram; Rudolph E Tanzi
Of replications and refutations: the status of Alzheimer's disease genetic research.
Current neurology and neuroscience reports 2001;1(5):442-50.
2001: Marilyn S Albert; Mark B Moss; Rudolph E Tanzi; K Jones
Preclinical prediction of AD using neuropsychological tests.
Journal of the International Neuropsychological Society : JINS 2001;7(5):631-9.
2001: Robert A Cherny; Craig S Atwood; Michel E Xilinas; D N Gray; Walton D Jones; Catriona A McLean; Kevin J Barnham; Irene Volitakis; Fiona Fraser; Y Kim; Xudong Huang; Lee E Goldstein; Robert D. Moir; JT Lim; Konrad Beyreuther; Hui Zheng; Rudolph E Tanzi; Colin L Masters; Ashley I Bush
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
Neuron 2001;30(3):665-76.
2001: Jin Woo Kim; T S Chang; J E Lee; Sung-Ho Huh; S W Yeon; W S Yang; CO Joe; Inhee Mook-Jung; Rudolph E Tanzi; TAE-WAN KIM; Eui-Ju Choi
Negative regulation of the SAPK/JNK signaling pathway by presenilin 1.
The Journal of cell biology 2001;153(3):457-63.
2001: Yuji Tanaka; Simone Engelender; S Igarashi; R K Rao; Tracy J Wanner; Rudolph E Tanzi; Akira Sawa; V L Dawson; Ted M Dawson; Christopher A Ross
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis.
Human molecular genetics 2001;10(9):919-26.
2001: G. William Rebeck; Robert D. Moir; Stanley K Mui; Dudley K Strickland; Rudolph E Tanzi; Bradley T Hyman
Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP.
Brain research. Molecular brain research 2001;87(2):238-45.
2001: Lars Bertram; Suzanne Y Guénette; Jennifer Jones; D Keeney; Kristina Mullin; A Crystal; Sanjay Basu; S Yhu; A Deng; G. William Rebeck; Bradley T Hyman; Rodney Go; Melvin G McInnis; Deborah Blacker; Rudolph E Tanzi
No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease.
Annals of neurology 2001;49(1):114-6.
2000: Lars Bertram; Deborah Blacker; Kristina Mullin; D Keeney; Jennifer Jones; Sanjay Basu; S Yhu; Melvin G McInnis; Rodney C P Go; K Vekrellis; Dennis J Selkoe; Aleister J Saunders; Rudolph E Tanzi
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.
Science (New York, N.Y.) 2000;290(5500):2302-3.
2000: Suzanne Y Guénette; Lars Bertram; A Crystal; B Bakondi; Bradley T Hyman; G. William Rebeck; Rudolph E Tanzi; Deborah Blacker
Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients.
Neuroscience letters 2000;296(1):17-20.
2000: Julianne Collins; Rodney T Perry; Bracie Watson; Lindy E Harrell; Ronald T Acton; Deborah Blacker; Marilyn S Albert; Rudolph E Tanzi; Susan S Bassett; Melvin G McInnis; R Duncan Campbell; Rodney C P Go
Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative.
American journal of medical genetics 2000;96(6):823-30.
2000: Lars Bertram; Deborah Blacker; A Crystal; Kristina Mullin; D Keeney; Jennifer Jones; Sanjay Basu; S Yhu; Suzanne Y Guénette; Melvin G McInnis; Rodney Go; Rudolph E Tanzi
Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies.
Experimental gerontology 2000;35(9-10):1353-61.
2000: Ying Liu; Melina Jones; C M Hingtgen; Guojun Bu; N Laribee; Rudolph E Tanzi; Robert D. Moir; Avindra Nath; Johnny J He
Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands.
Nature medicine 2000;6(12):1380-7.
2000: Joseph Buxbaum; Christina Lilliehook; J Y Chan; Rodney C P Go; Susan S Bassett; Rudolph E Tanzi; Wilma Wasco; Deborah Blacker
Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease.
Neuroscience letters 2000;294(3):135-8.
2000: N Sawamura; Maho Morishima-Kawashima; Hironori Waki; K Kobayashi; T Kuramochi; M P Frosch; K Ding; Mie Ito; T W Kim; Rudolph E Tanzi; Fumitaka Oyama; Takeshi Tabira; S Ando; Yasuo Ihara
Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin.
The Journal of biological chemistry 2000;275(36):27901-8.
2000: A S Yoo; I Cheng; S Chung; T Z Grenfell; H Lee; E Pack-Chung; M Handler; Jie Shen; Weiming Xia; Giuseppina Tesco; Aleister J Saunders; K Ding; Matthew P Frosch; Rudolph E Tanzi; TW Kim
Presenilin-mediated modulation of capacitative calcium entry.
Neuron 2000;27(3):561-72.
2000: Craig S Atwood; RC Scarpa; Xudong Huang; Robert D. Moir; Walton D Jones; D P Fairlie; Rudolph E Tanzi; Ashley I Bush
Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42.
Journal of neurochemistry 2000;75(3):1219-33.
2000: Rudolph E Tanzi
Alzheimer's disease and related dementias: the road to intervention.
Experimental gerontology 2000;35(4):433-7.
2000: Lee E Goldstein; M C Leopold; Xudong Huang; Craig S Atwood; Aleister J Saunders; Mariana A Hartshorn; JT Lim; K Y Faget; J A Muffat; RC Scarpa; Leo T Chylack; E F Bowden; Rudolph E Tanzi; Ashley I Bush
3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction.
Biochemistry 2000;39(24):7266-75.
2000: Robert A Cherny; Kevin J Barnham; T Lynch; Irene Volitakis; Qiao-Xin Li; Catriona A McLean; Gerd Multhaup; Konrad Beyreuther; Rudolph E Tanzi; Colin L Masters; Ashley I Bush
Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.
Journal of structural biology 2000;130(2-3):209-16.
2000: Craig S Atwood; Xudong Huang; Ashok Khatri; RC Scarpa; Y S Kim; Robert D. Moir; Rudolph E Tanzi; Alex Roher; Ashley I Bush
Copper catalyzed oxidation of Alzheimer Abeta.
Cellular and molecular biology (Noisy-le-Grand, France) 2000;46(4):777-83.
2000: E Pack-Chung; M B Meyers; W P Pettingell; Robert D. Moir; A M Brownawell; I Cheng; Rudolph E Tanzi; TW Kim
Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor.
The Journal of biological chemistry 2000;275(19):14440-5.
2000: Xudong Huang; Math P Cuajungco; Craig S Atwood; Robert D. Moir; Rudolph E Tanzi; Ashley I Bush
Alzheimer's disease, beta-amyloid protein and zinc.
The Journal of nutrition 2000;130(5S Suppl):1488S-92S.
2000: Ronald J Killiany; T Gomez-Isla; M Moss; R Kikinis; T Sandor; Ferenc A Jolesz; Rudolph E Tanzi; K Jones; Bradley T Hyman; Marilyn S Albert
Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease.
Annals of neurology 2000;47(4):430-9.
2000: Paula G Ulery; J Beers; Irina Mikhailenko; Rudolph E Tanzi; G. William Rebeck; Bradley T Hyman; Dudley K Strickland
Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.
The Journal of biological chemistry 2000;275(10):7410-5.
2000: Rudolph E Tanzi
Alzheimer's disease risk and the interleukin-1 genes.
Annals of neurology 2000;47(3):283-5.
2000: Giovanni Abbenante; Dora M. Kovacs; D L Leung; David J Craik; Rudolph E Tanzi; David P Fairlie
Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site.
Biochemical and biophysical research communications 2000;268(1):133-5.
2000: Math P Cuajungco; K Y Fagét; Xudong Huang; Rudolph E Tanzi; Ashley I Bush
Metal chelation as a potential therapy for Alzheimer's disease.
Annals of the New York Academy of Sciences 2000;920():292-304.
2000: Laura A Mackenzie Ingano; K M Lentini; I Kovacs; Rudolph E Tanzi; Dora M. Kovacs
Cytoplasmic presenilin aggregates in proteasome inhibitor-treated cells.
Annals of the New York Academy of Sciences 2000;920():259-60.
2000: Giuseppina Tesco; Rudolph E Tanzi
GSK3 beta forms a tetrameric complex with endogenous PS1-CTF/NTF and beta-catenin. Effects of the D257/D385A and FAD-linked mutations.
Annals of the New York Academy of Sciences 2000;920():227-32.
1999: Xudong Huang; Math P Cuajungco; Craig S Atwood; Mariana A Hartshorn; J D Tyndall; G R Hanson; K C Stokes; M Leopold; Gerd Multhaup; Lee E Goldstein; RC Scarpa; Aleister J Saunders; J Lim; Robert D. Moir; C Glabe; E F Bowden; Colin L Masters; D P Fairlie; Rudolph E Tanzi; Ashley I Bush
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.
The Journal of biological chemistry 1999;274(52):37111-6.
1999: Dora M. Kovacs; R Mancini; J Henderson; S J Na; S D Schmidt; TW Kim; Rudolph E Tanzi
Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells.
Journal of neurochemistry 1999;73(6):2278-85.
1999: Rudolph E Tanzi
A genetic dichotomy model for the inheritance of Alzheimer's disease and common age-related disorders.
The Journal of clinical investigation 1999;104(9):1175-9.
1999: Suzanne Y Guénette; J Chen; A Ferland; Christian Haass; A Capell; Rudolph E Tanzi
hFE65L influences amyloid precursor protein maturation and secretion.
Journal of neurochemistry 1999;73(3):985-93.
1999: Robert A Cherny; J T Legg; Catriona A McLean; D P Fairlie; Xudong Huang; Craig S Atwood; Konrad Beyreuther; Rudolph E Tanzi; Colin L Masters; Ashley I Bush
Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.
The Journal of biological chemistry 1999;274(33):23223-8.
1999: Robert D. Moir; Craig S Atwood; Xudong Huang; Rudolph E Tanzi; Ashley I Bush
Mounting evidence for the involvement of zinc and copper in Alzheimer's disease.
European journal of clinical investigation 1999;29(7):569-70.
1999: Rudolph E Tanzi
Caspases land on APP: one small step for apoptosis, one giant leap for amyloidosis?
Nature neuroscience 1999;2(7):585-6.
1999: Xudong Huang; Craig S Atwood; Mariana A Hartshorn; Gerd Multhaup; Lee E Goldstein; RC Scarpa; Math P Cuajungco; D N Gray; J Lim; Robert D. Moir; Rudolph E Tanzi; Ashley I Bush
The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction.
Biochemistry 1999;38(24):7609-16.
1999: Robert D. Moir; Craig S Atwood; Donna M Romano; M H Laurans; Xudong Huang; Ashley I Bush; Jonathan D. Smith; Rudolph E Tanzi
Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations.
Biochemistry 1999;38(14):4595-603.
1999: Suzanne Y Guénette; Rudolph E Tanzi
Progress toward valid transgenic mouse models for Alzheimer's disease.
Neurobiology of aging 1999;20(2):201-11.
1999: Craig S Atwood; Xudong Huang; Robert D. Moir; Rudolph E Tanzi; Ashley I Bush
Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease.
Metal ions in biological systems 1999;36():309-64.
1998: Giuseppina Tesco; TW Kim; A Diehlmann; Konrad Beyreuther; Rudolph E Tanzi
Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation.
The Journal of biological chemistry 1998;273(51):33909-14.
1998: A Liao; Roger M Nitsch; Steven M Greenberg; Ulrich Finckh; Deborah Blacker; Marilyn S Albert; G. William Rebeck; Teresa Gomez-Isla; AE Clatworthy; Giuliano Binetti; Christoph Hock; T Mueller-Thomsen; Ulrike Mann; K Zuchowski; U Beisiegel; Hannes B Staehelin; John H Growdon; Rudolph E Tanzi; Bradley T Hyman
Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.
Human molecular genetics 1998;7(12):1953-6.
1998: TW Kim; Rudolph E Tanzi
Neuronal intranuclear inclusions in polyglutamine diseases: nuclear weapons or nuclear fallout?
Neuron 1998;21(4):657-9.
1998: Rudolph E Tanzi
Of calcium, caspases, and cognitive decline.
Nature medicine 1998;4(10):1127-8.
1998: Dora M. Kovacs; Rudolph E Tanzi
Monogenic determinants of familial Alzheimer's disease: presenilin-1 mutations.
Cellular and molecular life sciences : CMLS 1998;54(9):902-9.
1998: Ashley I Bush; Rudolph E Tanzi
Alzheimer disease-related abnormalities of amyloid beta precursor protein isoforms in the platelet: the brain's delegate in the periphery?
Archives of neurology 1998;55(9):1179-80.
1998: MJ McNamara; C T Ruff; Wilma Wasco; Rudolph E Tanzi; Gopal Thinakaran; Bradley T Hyman
Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains.
Brain research 1998;804(1):45-51.
1998: Deborah Blacker; Marsha A. Wilcox; Nan M Laird; L Rodes; S M Horvath; Rodney C P Go; Rodney T Perry; Bracie Watson; Susan S Bassett; Melvin G McInnis; Marilyn S Albert; Bradley T Hyman; Rudolph E Tanzi
Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
Nature genetics 1998;19(4):357-60.
1998: René Etcheberrigaray; N Hirashima; L Nee; J Prince; Stefano Govoni; Marco Racchi; Rudolph E Tanzi; Daniel L Alkon
Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families.
Neurobiology of disease 1998;5(1):37-45.
1998: MengQi Xia; Oksana Berezovska; TW Kim; W M Xia; A Liao; Rudolph E Tanzi; Dennis J Selkoe; Bradley T Hyman
Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease.
Journal of the neurological sciences 1998;158(1):15-23.
1998: Craig S Atwood; Robert D. Moir; Xudong Huang; RC Scarpa; N M Bacarra; Donna M Romano; Mariana A Hartshorn; Rudolph E Tanzi; Ashley I Bush
Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.
The Journal of biological chemistry 1998;273(21):12817-26.
1998: Deborah Blacker; Rudolph E Tanzi
The genetics of Alzheimer disease: current status and future prospects.
Archives of neurology 1998;55(3):294-6.
1998: Robert D. Moir; T Lynch; Ashley I Bush; S Whyte; A Henry; S Portbury; Gerd Multhaup; David Small; Rudolph E Tanzi; Konrad Beyreuther; Colin L Masters
Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain.
The Journal of biological chemistry 1998;273(9):5013-9.
1998: Donald L Price; Rudolph E Tanzi; David R Borchelt; Sangram S Sisodia
Alzheimer's disease: genetic studies and transgenic models.
Annual review of genetics 1998;32():461-93.
1998: Christoph Hock; S Golombowski; Franz Müller-Spahn; W Naser; Konrad Beyreuther; U Mönning; Dale Schenk; C Vigo-Pelfrey; Ashley I Bush; Robert D. Moir; Rudolph E Tanzi; John H Growdon; Roger M Nitsch
Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity.
European neurology 1998;39(2):111-8.
1997: Caleb E Finch; Rudolph E Tanzi
Genetics of aging.
Science (New York, N.Y.) 1997;278(5337):407-11.
1997: Xudong Huang; Craig S Atwood; Robert D. Moir; Mariana A Hartshorn; J P Vonsattel; Rudolph E Tanzi; Ashley I Bush
Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.
The Journal of biological chemistry 1997;272(42):26464-70.
1997: TW Kim; Rudolph E Tanzi
Presenilins and Alzheimer's disease.
Current opinion in neurobiology 1997;7(5):683-8.
1997: TW Kim; Warren H Pettingell; Yong-Keun Jung; Dora M. Kovacs; Rudolph E Tanzi
Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease.
Science (New York, N.Y.) 1997;277(5324):373-6.
1997: T Gómez-Isla; Wilma Wasco; W P Pettingell; S Gurubhagavatula; S D Schmidt; P D Jondro; MJ McNamara; L A Rodes; T DiBlasi; Whitfield B Growdon; Peter Seubert; Dale Schenk; John H Growdon; Bradley T Hyman; Rudolph E Tanzi
A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes.
Annals of neurology 1997;41(6):809-13.
1997: M Seeger; C Nordstedt; Suzana Petanceska; Dora M. Kovacs; Gunnar K Gouras; S Hahne; Paul E Fraser; L Levesque; Andrew J Czernik; Peter St George-Hyslop; Sangram S Sisodia; Gopal Thinakaran; Rudolph E Tanzi; Paul Greengard; Sam Gandy
Evidence for phosphorylation and oligomeric assembly of presenilin 1.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5090-4.
1997: TW Kim; Warren H Pettingell; O G Hallmark; Robert D. Moir; Wilma Wasco; Rudolph E Tanzi
Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells.
The Journal of biological chemistry 1997;272(17):11006-10.
1997: Takahiro Suzuki; K Ando; T Isohara; M Oishi; G S Lim; Y Satoh; Wilma Wasco; Rudolph E Tanzi; Angus Nairn; Paul Greengard; Sam Gandy; Yutaka Kirino
Phosphorylation of Alzheimer beta-amyloid precursor-like proteins.
Biochemistry 1997;36(15):4643-9.
1997: Carlo Pesce; R Rossi; E Lenti; Rudolph E Tanzi
G-cell density in the antral mucosa: a feasibility study.
Histopathology 1997;30(4):315-8.
1997: Deborah Blacker; Jonathan L Haines; L Rodes; H Terwedow; Rodney C P Go; Lindy E Harrell; Rodney T Perry; Susan S Bassett; Gary A Chase; Deborah A Meyers; Marilyn S Albert; Rudolph E Tanzi
ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative.
Neurology 1997;48(1):139-47.
1997: Oksana Berezovska; MengQi Xia; K Page; Wilma Wasco; Rudolph E Tanzi; Bradley T Hyman
Developmental regulation of presenilin mRNA expression parallels notch expression.
Journal of neuropathology and experimental neurology 1997;56(1):40-4.
1996: K Page; RD Hollister; Rudolph E Tanzi; Bradley T Hyman
In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):14020-4.
1996: Suzanne Y Guénette; J Chen; P D Jondro; Rudolph E Tanzi
Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10832-7.
1996: D G Cook; J C Sung; todd golde; K M Felsenstein; Boguslaw S Wojczyk; Rudolph E Tanzi; John Q Trojanowski; Virginia M-Y Lee; Robert W Doms
Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9223-8.
1996: Michael C Irizarry; T W Kim; M McNamara; Rudolph E Tanzi; Julia M George; David F Clayton; Bradley T Hyman
Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system.
Journal of neuropathology and experimental neurology 1996;55(8):889-95.
1996: Donalyn Scheuner; Christopher B Eckman; M Jensen; X Song; Martin Citron; N Suzuki; Thomas D Bird; John Hardy; Michael Hutton; Walter A Kukull; Eric B Larson; Ephrat Levy-Lahad; Matti Viitanen; Elaine Peskind; Parvoneh Poorkaj-Navas; Gerard D Schellenberg; Rudolph E Tanzi; Wilma Wasco; Lars Lannfelt; Dennis J Selkoe; Steven G Younkin
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
Nature medicine 1996;2(8):864-70.
1996: Dora M. Kovacs; H J Fausett; K J Page; TW Kim; Robert D. Moir; D E Merriam; RD Hollister; O G Hallmark; R Mancini; K M Felsenstein; Bradley T Hyman; Rudolph E Tanzi; Wilma Wasco
Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.
Nature medicine 1996;2(2):224-9.
1996: Rudolph E Tanzi; Dora M. Kovacs; TW Kim; Robert D. Moir; S Y Guenette; Wilma Wasco
The gene defects responsible for familial Alzheimer's disease.
Neurobiology of disease 1996;3(3):159-68.
1996: Rudolph E Tanzi
Neuropathology in the Down's syndrome brain.
Nature medicine 1996;2(1):31-2.
1995: Bradley T Hyman; Rudolph E Tanzi
Molecular epidemiology of Alzheimer's disease.
The New England journal of medicine 1995;333(19):1283-4.
1995: Dora M. Kovacs; Wilma Wasco; J Witherby; K M Felsenstein; F Brunel; R G Roeder; Rudolph E Tanzi
The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene.
Human molecular genetics 1995;4(9):1527-33.
1995: M T Webster; N Groome; Paul T Francis; B R Pearce; F E Sherriff; Gopal Thinakaran; K M Felsenstein; Wilma Wasco; Rudolph E Tanzi; DM Bowen
A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media.
The Biochemical journal 1995;310 ( Pt 1)():95-9.
1995: TW Kim; Kuo Wu; J L Xu; G McAuliffe; Rudolph E Tanzi; Wilma Wasco; Ira B Black
Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density.
Brain research. Molecular brain research 1995;32(1):36-44.
1995: M Z Kounnas; Robert D. Moir; G. William Rebeck; Ashley I Bush; Scott Argraves; Rudolph E Tanzi; Bradley T Hyman; Dudley K Strickland
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation.
Cell 1995;82(2):331-40.
1995: Elizabeth H Corder; Ann M Saunders; Warren J Strittmatter; Donald E Schmechel; Perry C Gaskell; J B Rimmler; P A Locke; P M Conneally; Kenneth E Schmader; Rudolph E Tanzi
Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease.
Neurology 1995;45(7):1323-8.
1995: Ashley I Bush; R D Moir; K M Rosenkranz; Rudolph E Tanzi
Response.
Science (New York, N.Y.) 1995;268(5219):1921-3.
1995: R Sherrington; Evgeny I Rogaev; Yan Liang; Ekaterina Rogaeva; Georges Levesque; Masaki Ikeda; H Chi; C Lin; G Li; K Holman; T Tsuda; L Mar; J F Foncin; A C Bruni; M P Montesi; Sandro Sorbi; I Rainero; L Pinessi; L Nee; I Chumakov; D Pollen; A Brookes; P Sanseau; R J Polinsky; W Wasco; H A Da Silva; J L Haines; M A Perkicak-Vance; Rudolph E Tanzi; Allen D Roses; Paul E Fraser; J M Rommens; Peter St George-Hyslop
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.
Nature 1995;375(6534):754-60.
1995: Rudolph E Tanzi
A promising animal model of Alzheimer's disease.
The New England journal of medicine 1995;332(22):1512-3.
1995: P A Locke; P M Conneally; Rudolph E Tanzi; James Gusella; Jonathan L Haines
Apolipoprotein E4 allele and Alzheimer disease: examination of allelic association and effect on age at onset in both early- and late-onset cases.
Genetic epidemiology 1995;12(1):83-92.
1994: P Gregor; S M Gaston; X Yang; J P O'Regan; D R Rosen; Rudolph E Tanzi; D Patterson; Jonathan L Haines; H Robert Horvitz; George R. Uhl
Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21.
Human genetics 1994;94(5):565-70.
1994: Ashley I Bush; Warren H Pettingell; M de Paradis; Rudolph E Tanzi; Wilma Wasco
The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily.
The Journal of biological chemistry 1994;269(43):26618-21.
1994: Youji Muramatsu; T Yamada; M Miura; T Sakai; Y Suzuki; T Serikawa; Rudolph E Tanzi; K Matsumoto
Wilson's disease gene is homologous to hts causing abnormal copper transport in Long-Evans cinnamon rats.
Gastroenterology 1994;107(4):1189-92.
1994: Ashley I Bush; Warren H Pettingell; Gerd Multhaup; M d Paradis; J P Vonsattel; James Gusella; Konrad Beyreuther; Colin L Masters; Rudolph E Tanzi
Rapid induction of Alzheimer A beta amyloid formation by zinc.
Science (New York, N.Y.) 1994;265(5177):1464-7.
1994: X Cai; P Szabo; G Ali; Rudolph E Tanzi; John P Blass
Pseudogene of dihydrolipoyl succinyltransferase (E2k) found by PCR amplification and direct sequencing of rodent-human cell hybrid DNAs.
Somatic cell and molecular genetics 1994;20(4):339-43.
1994: Ashley I Bush; Warren H Pettingell; M D Paradis; Rudolph E Tanzi
Modulation of A beta adhesiveness and secretase site cleavage by zinc.
The Journal of biological chemistry 1994;269(16):12152-8.
1994: G Ali; Wilma Wasco; X Cai; P Szabo; KF Sheu; A J Cooper; S M Gaston; James Gusella; Rudolph E Tanzi; John P Blass
Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex.
Somatic cell and molecular genetics 1994;20(2):99-105.
1994: Hilda H Slunt; Gopal Thinakaran; C Von Koch; Amy Lo; Rudolph E Tanzi; Sangram S Sisodia
Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).
The Journal of biological chemistry 1994;269(4):2637-44.
1994: Rudolph E Tanzi; Ashley I Bush; Wilma Wasco
Genetic studies of Alzheimer's disease: lessons learned and future imperatives.
Neurobiology of aging 1994;15 Suppl 2():S145-8.
1993: Rudolph E Tanzi; Konstantin Petrukhin; I Chernov; Jean-Luc Pellequer; Wilma Wasco; B Ross; Donna M Romano; Enrico Parano; L Pavone; Linda M Brzustowicz
The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene.
Nature genetics 1993;5(4):344-50.
1993: Konstantin Petrukhin; SG Fischer; M Pirastu; Rudolph E Tanzi; I Chernov; M Devoto; Linda M Brzustowicz; Eftihia Cayanis; E Vitale; James J Russo
Mapping, cloning and genetic characterization of the region containing the Wilson disease gene.
Nature genetics 1993;5(4):338-43.
1993: Evgeny I Rogaev; Walter J Lukiw; Giovanna Vaula; Jonathan L Haines; Ekaterina Rogaeva; T Tsuda; N Alexandrova; Yan Liang; M Mortilla; Luigi Amaducci; L Bergamini; A C Bruni; J F Foncin; F Macciardi; M Montesi; Sandro Sorbi; I Rainero; L Pinessi; R J Polinsky; Peter Frommelt; Ranjan Duara; Roberto Lopez; D Pollen; James Gusella; Rudolph E Tanzi; D MacLachlan; D Crapper; Peter St George-Hyslop
Analysis of the c-FOS gene on chromosome 14 and the promoter of the amyloid precursor protein gene in familial Alzheimer's disease.
Neurology 1993;43(11):2275-9.
1993: Wilma Wasco; J Peppercorn; Rudolph E Tanzi
Search for the genes responsible for familial Alzheimer's disease.
Annals of the New York Academy of Sciences 1993;695():203-8.
1993: Wilma Wasco; S Gurubhagavatula; M D Paradis; Donna M Romano; Sangram S Sisodia; Bradley T Hyman; R L Neve; Rudolph E Tanzi
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor.
Nature genetics 1993;5(1):95-100.
1993: Rudolph E Tanzi; J J Wenniger; Bradley T Hyman
Cellular specificity and regional distribution of amyloid beta protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation.
Brain research. Molecular brain research 1993;18(3):246-52.
1993: Bradley T Hyman; J J Wenniger; Rudolph E Tanzi
Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques.
Brain research. Molecular brain research 1993;18(3):253-8.
1993: Wilma Wasco; J D Brook; Rudolph E Tanzi
The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19.
Genomics 1993;15(1):237-9.
1993: Margaret Pericak-Vance; Peter St George-Hyslop; Perry C Gaskell; John H Growdon; Barbara J Crain; Christine M Hulette; James Gusella; LH Yamaoka; Rudolph E Tanzi; Allen D Roses
Linkage analysis in familial Alzheimer disease: description of the Duke and Boston data sets.
Genetic epidemiology 1993;10(6):361-4.
1993: Rudolph E Tanzi; S Gaston; Ashley I Bush; Donna M Romano; W Pettingell; J Peppercorn; M Paradis; S Gurubhagavatula; B Jenkins; Wilma Wasco
Genetic heterogeneity of gene defects responsible for familial Alzheimer disease.
Genetica 1993;91(1-3):255-63.
1993: P A Locke; Marcy E MacDonald; J Srinidhi; T C Gilliam; Rudolph E Tanzi; P M Conneally; N S Wexler; Jonathan L Haines; James Gusella
A genetic linkage map of the chromosome 4 short arm.
Somatic cell and molecular genetics 1993;19(1):95-101.
1992: Peter St George-Hyslop; Jonathan L Haines; Evgeny I Rogaev; M Mortilla; Giovanna Vaula; Margaret Pericak-Vance; J F Foncin; M Montesi; A Bruni; Sandro Sorbi; I Rainero; L Pinessi; D Pollen; R Polinsky; L Nee; J Kennedy; F Macciardi; E Rogaeva; Y Liang; N Alexandrova; W Lukiw; K Schlumpf; Rudolph E Tanzi; T Tsuda; L Farrer; J M Cantu; Ranjan Duara; L Amaducci; L Bergamini; James Gusella; Allen D Roses; D Crapper McLachlan
Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.
Nature genetics 1992;2(4):330-4.
1992: Wilma Wasco; K Bupp; M Magendantz; James Gusella; Rudolph E Tanzi; Frank Solomon
Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10758-62.
1992: Rudolph E Tanzi; Donna M Romano; R Berger; Monika Buraczynska; S M Gaston; David M Kurnit; D Patterson; James Gusella; G D Stewart
Sequence-tagged sites (STSs) for a set of mapped markers on chromosome 21.
Genomics 1992;14(2):498-502.
1992: Giovanna Vaula; M Mortilla; R Tupler; Walter J Lukiw; Rudolph E Tanzi; Linda E Nee; R Polinsky; J F Foncin; A C Bruni; M P Montesi
A novel but non-pathogenic mutation in exon 4 of the human amyloid precursor protein (APP) gene.
Neuroscience letters 1992;144(1-2):46-8.
1992: Rudolph E Tanzi; Giovanna Vaula; Donna M Romano; M Mortilla; T L Huang; R G Tupler; Wilma Wasco; Bradley T Hyman; Jonathan L Haines; B J Jenkins
Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases.
American journal of human genetics 1992;51(2):273-82.
1992: L Fidani; K Rooke; Marie-Christine Chartier-Harlin; D Hughes; Rudolph E Tanzi; Michael Mullan; P Roques; Martin N Rossor; John Hardy; Alison Goate
Screening for mutations in the open reading frame and promoter of the beta-amyloid precursor protein gene in familial Alzheimer's disease: identification of a further family with APP717 Val-->Ile.
Human molecular genetics 1992;1(3):165-8.
1992: Rudolph E Tanzi; P C Watkins; G D Stewart; N S Wexler; James Gusella; Jonathan L Haines
A genetic linkage map of human chromosome 21: analysis of recombination as a function of sex and age.
American journal of human genetics 1992;50(3):551-8.
1992: Bradley T Hyman; Rudolph E Tanzi
Amyloid, dementia and Alzheimer's disease.
Current opinion in neurology and neurosurgery 1992;5(1):88-93.
1992: Bradley T Hyman; Rudolph E Tanzi; K Marzloff; R Barbour; Dale Schenk
Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease.
Journal of neuropathology and experimental neurology 1992;51(1):76-83.
1992: Jonathan L Haines; J A Trofatter; Rudolph E Tanzi; P Watkins; N S Wexler; P M Conneally; James Gusella
Chromosome 21 genetic linkage data set based on the Venezuelan reference pedigree.
Cytogenetics and cell genetics 1992;59(2-3):88-9.
1991: Rudolph E Tanzi; Peter St George-Hyslop; James Gusella
Molecular genetics of Alzheimer disease amyloid.
The Journal of biological chemistry 1991;266(31):20579-82.
1991: Rudolph E Tanzi
Genetic linkage studies of human neurodegenerative disorders.
Current opinion in neurobiology 1991;1(3):455-61.
1991: Rudolph E Tanzi
Gene mutations in inherited amyloidopathies of the nervous system.
American journal of human genetics 1991;49(3):507-10.
1991: K Abe; Rudolph E Tanzi; K Kogure
Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex.
Neuroscience letters 1991;125(2):172-4.
1991: K Abe; Rudolph E Tanzi; K Kogure
Induction of HSP70 mRNA after transient ischemia in gerbil brain.
Neuroscience letters 1991;125(2):166-8.
1991: K Abe; Peter St George-Hyslop; Rudolph E Tanzi; K Kogure
Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells.
Neuroscience letters 1991;125(2):169-71.
1991: Rudolph E Tanzi; Bradley T Hyman
Alzheimer's mutation.
Nature 1991;350(6319):564.
1991: Rudolph E Tanzi; Bradley T Hyman
Studies of amyloid beta-protein precursor expression in Alzheimer's disease.
Annals of the New York Academy of Sciences 1991;640():149-54.
1990: T J Lerner; E Arn; M A Anderson; Katherine W Klinger; D F Callen; Rudolph E Tanzi
Two RFLPs detected by a cosmid at locus D16S144.
Nucleic acids research 1990;18(16):4962.
1990: Rudolph E Tanzi; Jonathan L Haines; James Gusella
Detailed genetic linkage map of human chromosome 21: patterns of recombination according to age and sex.
Progress in clinical and biological research 1990;360():15-26.
1990: Rudolph E Tanzi
The Alzheimer disease-associated amyloid beta protein precursor gene and familial Alzheimer disease.
Progress in clinical and biological research 1990;360():187-99.
1990: M R Palmert; Marcia B Podlisny; todd golde; M L Cohen; Dora M. Kovacs; Rudolph E Tanzi; James Gusella; Peter J Whitehouse; D S Witker; Tilman Oltersdorf
Analysis of the beta-amyloid protein precursor of Alzheimer's disease: mRNAs and protein products.
Advances in neurology 1990;51():181-4.
1989: Peter St George-Hyslop; Jonathan L Haines; R J Polinsky; Rudolph E Tanzi; Lindsay A Farrer; Richard H Myers; James Gusella
Molecular genetics of familial Alzheimer's disease.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1989;16(4 Suppl):465-7.
1989: Peter St George-Hyslop; Richard H Myers; Jonathan L Haines; Lindsay A Farrer; Rudolph E Tanzi; K Abe; M F James; P M Conneally; R J Polinsky; James Gusella
Familial Alzheimer's disease: progress and problems.
Neurobiology of aging 1989;10(5):417-25.
1989: P M Conneally; Jonathan L Haines; Rudolph E Tanzi; N S Wexler; G K Penchaszadeh; P S Harper; Susan E Folstein; J J Cassiman; Richard H Myers; Anne B Young
Huntington disease: no evidence for locus heterogeneity.
Genomics 1989;5(2):304-8.
1989: M L Van Keuren; G D Stewart; C M Bradley; David M Kurnit; R L Neve; P C Watkins; Rudolph E Tanzi; James Gusella; D Patterson
Characterization of an unusual and complex chromosome 21 rearrangement using somatic cell genetics and cloned DNA probes.
American journal of medical genetics 1989;33(3):369-75.
1989: Rudolph E Tanzi; Peter St George-Hyslop; James Gusella
Molecular genetic approaches to Alzheimer's disease.
Trends in neurosciences 1989;12(4):152-8.
1989: Peter St George-Hyslop; Rudolph E Tanzi; Jonathan L Haines; R J Polinsky; Lindsay A Farrer; Richard H Myers; James Gusella
Molecular genetics of familial Alzheimer's disease.
European neurology 1989;29 Suppl 3():25-7.
1989: M R Palmert; Marcia B Podlisny; todd golde; M L Cohen; Dora M. Kovacs; Rudolph E Tanzi; James Gusella; Peter J Whitehouse; D S Witker; Tilman Oltersdorf
The beta amyloid protein precursor: mRNAs, membrane-associated forms, and soluble derivatives.
Progress in clinical and biological research 1989;317():971-84.
1989: Rudolph E Tanzi
Molecular genetics of Alzheimer's disease and the amyloid beta peptide precursor gene.
Annals of medicine 1989;21(2):91-4.
1988: D Patterson; Katheleen Gardiner; F T Kao; Rudolph E Tanzi; P Watkins; James Gusella
Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(21):8266-70.
1988: Mary C Phelan; C C Morton; Roger E Stevenson; Rudolph E Tanzi; G D Stewart; P C Watkins; James Gusella; J A Amos
Molecular and cytogenetic characterization of a de novo t(5p;21q) in a patient previously diagnosed as monosomy 21.
American journal of human genetics 1988;43(4):511-9.
1988: M R Palmert; todd golde; M L Cohen; Dora M. Kovacs; Rudolph E Tanzi; James Gusella; M F Usiak; Linda Younkin; Steven G Younkin
Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease.
Science (New York, N.Y.) 1988;241(4869):1080-4.
1988: Nicoletta Sacchi; S V Cheng; Rudolph E Tanzi; James Gusella; Harry A Drabkin; D Patterson; Jonathan L Haines; TS Papas
The ETS genes on chromosome 21 are distal to the breakpoint of the acute myelogenous leukemia translocation (8;21).
Genomics 1988;3(2):110-6.
1988: Rudolph E Tanzi; Jonathan L Haines; P C Watkins; G D Stewart; M R Wallace; R Hallewell; C Wong; N S Wexler; P M Conneally; James Gusella
Genetic linkage map of human chromosome 21.
Genomics 1988;3(2):129-36.
1988: S V Cheng; Joseph H Nadeau; Rudolph E Tanzi; P C Watkins; J Jagadesh; B A Taylor; Jonathan L Haines; Nicoletta Sacchi; James Gusella
Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):6032-6.
1988: Sharon L Graw; J Davidson; James Gusella; P Watkins; Rudolph E Tanzi; R Neve; D Patterson
Irradiation-reduced human chromosome 21 hybrids.
Somatic cell and molecular genetics 1988;14(3):233-42.
1988: Rudolph E Tanzi; Andrea I McClatchey; E D Lamperti; L Villa-Komaroff; James Gusella; R L Neve
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.
Nature 1988;331(6156):528-30.
1988: G D Stewart; Terry J Hassold; A Berg; P Watkins; Rudolph E Tanzi; David M Kurnit
Trisomy 21 (Down syndrome): studying nondisjunction and meiotic recombination by using cytogenetic and molecular polymorphisms that span chromosome 21.
American journal of human genetics 1988;42(2):227-36.
1987: Rudolph E Tanzi; E D Bird; S A Latt; R L Neve
The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease.
Science (New York, N.Y.) 1987;238(4827):666-9.
1987: Peter St George-Hyslop; Rudolph E Tanzi; R J Polinsky; R L Neve; Daniel A Pollen; Daniel B Drachman; John H Growdon; L A Cupples; Linda E Nee; Richard H Myers
Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease.
Science (New York, N.Y.) 1987;238(4827):664-6.
1987: S V Cheng; T Gross Lugo; Rudolph E Tanzi; J B Whitney; R E Fournier; James Gusella
Chromosomal localization of the mouse homolog of the Huntington's disease linked G8 (D4S10) marker.
DNA (Mary Ann Liebert, Inc.) 1987;6(5):401-7.
1987: Rudolph E Tanzi; Peter St George-Hyslop; Jonathan L Haines; R J Polinsky; L Nee; J F Foncin; R L Neve; Andrea I McClatchey; P M Conneally; James Gusella
The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene.
Nature 1987;329(6135):156-7.
1987: T C Gilliam; Rudolph E Tanzi; Jonathan L Haines; T I Bonner; A G Faryniarz; W J Hobbs; Marcy E MacDonald; S V Cheng; Susan E Folstein; P M Conneally
Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere.
Cell 1987;50(4):565-71.
1987: P C Watkins; R Eddy; A K Beck; V Vellucci; B Leverone; Rudolph E Tanzi; James Gusella; T B Shows
DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11.
DNA (Mary Ann Liebert, Inc.) 1987;6(3):205-12.
1987: P C Watkins; Rudolph E Tanzi; S V Cheng; James Gusella
Molecular genetics of human chromosome 21.
Journal of medical genetics 1987;24(5):257-70.
1987: N S Wexler; Anne B Young; Rudolph E Tanzi; H Travers; S Starosta-Rubinstein; John B Penney; S R Snodgrass; Ira Shoulson; F Gomez; M A Ramos Arroyo
Homozygotes for Huntington's disease.
Nature 1987;326(6109):194-7.
1987: T C Gilliam; S T Healey; Marcy E MacDonald; G D Stewart; J J Wasmuth; Rudolph E Tanzi; J C Roy; James Gusella
Isolation of polymorphic DNA fragments from human chromosome 4.
Nucleic acids research 1987;15(4):1445-58.
1987: Rudolph E Tanzi; James Gusella; P C Watkins; G A Bruns; Peter St George-Hyslop; M L Van Keuren; D Patterson; S Pagan; David M Kurnit; R L Neve
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.
Science (New York, N.Y.) 1987;235(4791):880-4.
1987: Peter St George-Hyslop; Rudolph E Tanzi; R J Polinsky; Jonathan L Haines; Linda E Nee; P C Watkins; Richard H Myers; R G Feldman; Daniel A Pollen; Daniel B Drachman
The genetic defect causing familial Alzheimer's disease maps on chromosome 21.
Science (New York, N.Y.) 1987;235(4791):885-90.
1987: Peter St George-Hyslop; R Polinsky; Jonathan L Haines; Linda E Nee; Rudolph E Tanzi; P Conneally; John H Growdon; Richard H Myers; Daniel A Pollen; Daniel B Drachman
Search for the familial Alzheimer's disease gene.
Journal of neural transmission. Supplementum 1987;24():13-21.
1986: S Youngman; M Sarfarazi; O W Quarrell; P M Conneally; K Gibbons; Peter S Harper; D J Shaw; Rudolph E Tanzi; M R Wallace; James Gusella
Studies of a DNA marker (G8) genetically linked to Huntington disease in British families.
Human genetics 1986;73(4):333-9.
1986: James Gusella; T C Gilliam; Marcy E MacDonald; S V Cheng; Rudolph E Tanzi
Molecular genetics of human chromosome 4.
Journal of medical genetics 1986;23(3):193-9.
1986: X O Breakefield; Susan Bressman; Patricia L Kramer; Laurie J Ozelius; C Moskowitz; Rudolph E Tanzi; Mitchell F Brin; W Hobbs; D Kaufman; A Tobin
Linkage analysis in a family with dominantly inherited torsion dystonia: exclusion of the pro-opiomelanocortin and glutamic acid decarboxylase genes and other chromosomal regions using DNA polymorphisms.
Journal of neurogenetics 1986;3(3):159-75.
1986: BR Seizinger; Rudolph E Tanzi; T C Gilliam; J L Bader; D M Parry; M A Spence; M L Marazita; K Gibbons; W Hobbs; James Gusella
Genetic linkage analysis of neurofibromatosis with DNA markers.
Annals of the New York Academy of Sciences 1986;486():304-10.
1986: James Gusella; T C Gilliam; Rudolph E Tanzi; Marcy E MacDonald; S V Cheng; M Wallace; Jonathan L Haines; P M Conneally; N S Wexler
Molecular genetics of Huntington's disease.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 1():359-64.
1985: Peter S Harper; S Youngman; M A Anderson; M Sarfarazi; O Quarrell; Rudolph E Tanzi; D Shaw; P Wallace; P M Conneally; James Gusella
Genetic linkage between Huntington's disease and the DNA polymorphism G8 in South Wales families.
Journal of medical genetics 1985;22(6):447-50.
1985: James Gusella; Rudolph E Tanzi; P I Bader; M C Phelan; R Stevenson; Michael R Hayden; K J Hofman; A G Faryniarz; K Gibbons
Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf-Hirschhorn syndrome.
Nature 1985;318(6041):75-8.
1985: G D Stewart; Rudolph E Tanzi; James Gusella
RFLPS at the D21S19 locus of human chromosome 21.
Nucleic acids research 1985;13(19):7168.
1985: P C Watkins; Rudolph E Tanzi; K T Gibbons; J V Tricoli; G Landes; R Eddy; T B Shows; James Gusella
Isolation of polymorphic DNA segments from human chromosome 21.
Nucleic acids research 1985;13(17):6075-88.
1985: S D Kittur; S E Antonarakis; Rudolph E Tanzi; Deborah A Meyers; Aravinda Chakravarti; Y Groner; J A Phillips; P C Watkins; James Gusella; Haig Kazazian
A linkage map of three anonymous human DNA fragments and SOD-1 on chromosome 21.
The EMBO journal 1985;4(9):2257-60.
1985: James Gusella; Rudolph E Tanzi; P C Watkins; K T Gibbons; W J Hobbs; A G Faryniarz; S T Healey; M A Anderson
Genetic linkage map for chromosome 21.
Annals of the New York Academy of Sciences 1985;450():25-31.
1984: James Gusella; Rudolph E Tanzi; M A Anderson; W Hobbs; K Gibbons; R Raschtchian; T C Gilliam; M R Wallace; N S Wexler; P M Conneally
DNA markers for nervous system diseases.
Science (New York, N.Y.) 1984;225(4668):1320-6.
1983: James Gusella; N S Wexler; P M Conneally; Susan Naylor; M A Anderson; Rudolph E Tanzi; P C Watkins; K Ottina; M R Wallace; A Y Sakaguchi
A polymorphic DNA marker genetically linked to Huntington's disease.
Nature 1983;306(5940):234-8.