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Rudolph Tanzi

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Bertram Lars; Tanzi Rudolph E
Genome-wide association studies in Alzheimer's disease.
Kim Minji; Suh Jaehong; Romano Donna; Truong Mimy H; Mullin Kristina; Hooli Basavaraj; Norton David; Tesco Giuseppina; Elliott Kathy; Wagner Steven L; Moir Robert D; Becker K David; Tanzi Rudolph E
Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.
Dong Yuanlin; Zhang Guohua; Zhang Bin; Moir Robert D; Xia Weiming; Marcantonio Edward R; Culley Deborah J; Crosby Gregory; Tanzi Rudolph E; Xie Zhongcong
The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels.

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All Publications

2009: Bertram Lars; Tanzi Rudolph E
Genome-wide association studies in Alzheimer's disease.
Human molecular genetics 2009;18(R2):R137-45.
2009: Kim Minji; Suh Jaehong; Romano Donna; Truong Mimy H; Mullin Kristina; Hooli Basavaraj; Norton David; Tesco Giuseppina; Elliott Kathy; Wagner Steven L; Moir Robert D; Becker K David; Tanzi Rudolph E
Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.
Human molecular genetics 2009;18(20):3987-96.
2009: Dong Yuanlin; Zhang Guohua; Zhang Bin; Moir Robert D; Xia Weiming; Marcantonio Edward R; Culley Deborah J; Crosby Gregory; Tanzi Rudolph E; Xie Zhongcong
The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels.
Archives of neurology 2009;66(5):620-31.
2009: Lu Alice; Hiltunen Mikko; Romano Donna M; Soininen Hilkka; Hyman Bradley T; Bertram Lars; Tanzi Rudolph E
Effects of ubiquilin 1 on the unfolded protein response.
Journal of molecular neuroscience : MN 2009;38(1):19-30.
2009: Myre Michael A; Washicosky Kevin; Moir Robert D; Tesco Giuseppina; Tanzi Rudolph E; Wasco Wilma
Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.
Cellular signalling 2009;21(4):567-76.
2009: Schjeide Brit-Maren M; Hooli Basavaraj; Parkinson Michele; Hogan Meghan F; DiVito Jason; Mullin Kristina; Blacker Deborah; Tanzi Rudolph E; Bertram Lars
GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results.
Archives of neurology 2009;66(2):250-4.
2009: Schjeide Brit-Maren M; McQueen Matthew B; Mullin Kristina; DiVito Jason; Hogan Meghan F; Parkinson Michele; Hooli Basavaraj; Lange Christoph; Blacker Deborah; Tanzi Rudolph E; Bertram Lars
Assessment of Alzheimer's disease case-control associations using family-based methods.
Neurogenetics 2009;10(1):19-25.
2008: Bertram Lars; Schjeide Brit-Maren M; Hooli Basavaraj; Mullin Kristina; Hiltunen Mikko; Soininen Hilkka; Ingelsson Martin; Lannfelt Lars; Blacker Deborah; Tanzi Rudolph E
No association between CALHM1 and Alzheimer's disease risk.
Cell 2008;135(6):993-4; author reply 994-6.
2008: Xie Zhongcong; Culley Deborah J; Dong Yuanlin; Zhang Guohua; Zhang Bin; Moir Robert D; Frosch Matthew P; Crosby Gregory; Tanzi Rudolph E
The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo.
Annals of neurology 2008;64(6):618-27.
2008: Cotton Richard G H; Auerbach Arleen D; Axton Myles; Barash Carol Isaacson; Berkovic Samuel F; Brookes Anthony J; Burn John; Cutting Garry; den Dunnen Johan T; Flicek Paul; Freimer Nelson; Greenblatt Marc S; Howard Heather J; Katz Michael; Macrae Finlay A; Maglott Donna; Möslein Gabriela; Povey Sue; Ramesar Rajkumar S; Richards Carolyn S; Seminara Daniela; Smith Timothy D; Sobrido María-Jesús; Solbakk Jan Helge; Tanzi Rudolph E; Tavtigian Sean V; Taylor Graham R; Utsunomiya Joji; Watson Michael
GENETICS. The Human Variome Project.
Science (New York, N.Y.) 2008;322(5903):861-2.
2008: Bertram Lars; Lange Christoph; Mullin Kristina; Parkinson Michele; Hsiao Monica; Hogan Meghan F; Schjeide Brit M M; Hooli Basavaraj; Divito Jason; Ionita Iuliana; Jiang Hongyu; Laird Nan; Moscarillo Thomas; Ohlsen Kari L; Elliott Kathryn; Wang Xin; Hu-Lince Diane; Ryder Marie; Murphy Amy; Wagner Steven L; Blacker Deborah; Becker K David; Tanzi Rudolph E
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.
American journal of human genetics 2008;83(5):623-32.
2008: Schaffer Barbara A J; Bertram Lars; Miller Bruce L; Mullin Kristina; Weintraub Sandra; Johnson Nancy; Bigio Eileen H; Mesulam Marsel; Wiedau-Pazos Martina; Jackson George R; Cummings Jeffrey L; Cantor Rita M; Levey Allan I; Tanzi Rudolph E; Geschwind Daniel H
Association of GSK3B with Alzheimer disease and frontotemporal dementia.
Archives of neurology 2008;65(10):1368-74.
2008: Lee In Ho; Culley Deborah J; Baxter Mark G; Xie Zhongcong; Tanzi Rudolph E; Crosby Gregory
Spatial memory is intact in aged rats after propofol anesthesia.
Anesthesia and analgesia 2008;107(4):1211-5.
2008: Bertram Lars; Tanzi Rudolph E
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses.
Nature reviews. Neuroscience 2008;9(10):768-78.
2008: Kavvoura Fotini K; McQueen Matthew B; Khoury Muin J; Tanzi Rudolph E; Bertram Lars; Ioannidis John P A
Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease.
American journal of epidemiology 2008;168(8):855-65.
2008: Tanzi Rudolph E; Bertram Lars
Alzheimer's disease: The latest suspect.
Nature 2008;454(7205):706-8.
2008: Bush Ashley I; Tanzi Rudolph E
Therapeutics for Alzheimer's disease based on the metal hypothesis.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2008;5(3):421-32.
2008: Tanzi Rudolph E
Novel therapeutics for Alzheimer's disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2008;5(3):377-80.
2008: Adlard Paul A; Cherny Robert A; Finkelstein David I; Gautier Elisabeth; Robb Elysia; Cortes Mikhalina; Volitakis Irene; Liu Xiang; Smith Jeffrey P; Perez Keyla; Laughton Katrina; Li Qiao-Xin; Charman Susan A; Nicolazzo Joseph A; Wilkins Simon; Deleva Karolina; Lynch Toni; Kok Gaik; Ritchie Craig W; Tanzi Rudolph E; Cappai Roberto; Masters Colin L; Barnham Kevin J; Bush Ashley I
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.
Neuron 2008;59(1):43-55.
2008: Allen Nicole C; Bagade Sachin; McQueen Matthew B; Ioannidis John P A; Kavvoura Fotini K; Khoury Muin J; Tanzi Rudolph E; Bertram Lars
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
Nature genetics 2008;40(7):827-34.
2008: Zhang Bin; Dong Yuanlin; Zhang Guohua; Moir Robert D; Xia Weiming; Yue Yun; Tian Ming; Culley Deborah J; Crosby Gregory; Tanzi Rudolph E; Xie Zhongcong
The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions.
The Journal of biological chemistry 2008;283(18):11866-75.
2008: Zhang Guohua; Dong Yuanlin; Zhang Bin; Ichinose Fumito; Wu Xu; Culley Deborah J; Crosby Gregory; Tanzi Rudolph E; Xie Zhongcong
Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(17):4551-60.
2008: Weiss Lauren A; Shen Yiping; Korn Joshua M; Arking Dan E; Miller David T; Fossdal Ragnheidur; Saemundsen Evald; Stefansson Hreinn; Ferreira Manuel A R; Green Todd; Platt Orah S; Ruderfer Douglas M; Walsh Christopher A; Altshuler David; Chakravarti Aravinda; Tanzi Rudolph E; Stefansson Kari; Santangelo Susan L; Gusella James F; Sklar Pamela; Wu Bai-Lin; Daly Mark J;
Association between microdeletion and microduplication at 16p11.2 and autism.
The New England journal of medicine 2008;358(7):667-75.
2008: Smith Eric E; Egorova Svetlana; Blacker Deborah; Killiany Ronald J; Muzikansky Alona; Dickerson Bradford C; Tanzi Rudolph E; Albert Marilyn S; Greenberg Steven M; Guttmann Charles R G
Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia.
Archives of neurology 2008;65(1):94-100.
2007: McQueen Matthew B; Bertram Lars; Lange Christoph; Becker K D; Albert Marilyn S; Tanzi Rudolph E; Blacker Deborah
Exploring candidate gene associations with neuropsychological performance.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(8):987-91.
2007: Hamshere Marian L; Holmans Peter A; Avramopoulos Dimitrios; Bassett Susan S; Blacker Deborah; Bertram Lars; Wiener Howard; Rochberg Nan; Tanzi Rudolph E; Myers Amanda; Wavrant-De Vrièze Fabienne; Go Rodney; Fallin Daniele; Lovestone Simon; Hardy John; Goate Alison; O'Donovan Michael; Williams Julie; Owen Michael J
Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease.
Human molecular genetics 2007;16(22):2703-12.
2007: Li Airong; Xie Zhongcong; Dong Yuanlin; McKay Kenneth M; McKee Mary L; Tanzi Rudolph E
Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes.
Human molecular genetics 2007;16(21):2626-39.
2007: Huttunen Henri J; Guénette Suzanne Y; Peach Camilla; Greco Christopher; Xia Weiming; Kim Doo Yeon; Barren Cory; Tanzi Rudolph E; Kovacs Dora M
HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation.
The Journal of biological chemistry 2007;282(38):28285-95.
2007: Vepsäläinen Saila; Parkinson Michele; Helisalmi Seppo; Mannermaa Arto; Soininen Hilkka; Tanzi Rudolph E; Bertram Lars; Hiltunen Mikko
Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population.
Journal of medical genetics 2007;44(9):606-8.
2007: Blacker Deborah; Lee Hang; Muzikansky Alona; Martin Emily C; Tanzi Rudolph; McArdle John J; Moss Mark; Albert Marilyn
Neuropsychological measures in normal individuals that predict subsequent cognitive decline.
Archives of neurology 2007;64(6):862-71.
2007: Tesco Giuseppina; Koh Young Ho; Kang Eugene L; Cameron Andrew N; Das Shinjita; Sena-Esteves Miguel; Hiltunen Mikko; Yang Shao-Hua; Zhong Zhenyu; Shen Yong; Simpkins James W; Tanzi Rudolph E
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity.
Neuron 2007;54(5):721-37.
2007: Albert Marilyn; Blacker Deborah; Moss Mark B; Tanzi Rudolph; McArdle John J
Longitudinal change in cognitive performance among individuals with mild cognitive impairment.
Neuropsychology 2007;21(2):158-69.
2007: Friedlich A L; Tanzi R E; Rogers J T
The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element.
Molecular psychiatry 2007;12(3):222-3.
2007: Szatmari Peter; Paterson Andrew D; Zwaigenbaum Lonnie; Roberts Wendy; Brian Jessica; Liu Xiao-Qing; Vincent John B; Skaug Jennifer L; Thompson Ann P; Senman Lili; Feuk Lars; Qian Cheng; Bryson Susan E; Jones Marshall B; Marshall Christian R; Scherer Stephen W; Vieland Veronica J; Bartlett Christopher; Mangin La Vonne; Goedken Rhinda; Segre Alberto; Pericak-Vance Margaret A; Cuccaro Michael L; Gilbert John R; Wright Harry H; Abramson Ruth K; Betancur Catalina; Bourgeron Thomas; Gillberg Christopher; Leboyer Marion; Buxbaum Joseph D; Davis Kenneth L; Hollander Eric; Silverman Jeremy M; Hallmayer Joachim; Lotspeich Linda; Sutcliffe James S; Haines Jonathan L; Folstein Susan E; Piven Joseph; Wassink Thomas H; Sheffield Val; Geschwind Daniel H; Bucan Maja; Brown W Ted; Cantor Rita M; Constantino John N; Gilliam T Conrad; Herbert Martha; Lajonchere Clara; Ledbetter David H; Lese-Martin Christa; Miller Janet; Nelson Stan; Samango-Sprouse Carol A; Spence Sarah; State Matthew; Tanzi Rudolph E; Coon Hilary; Dawson Geraldine; Devlin Bernie; Estes Annette; Flodman Pamela; Klei Lambertus; McMahon William M; Minshew Nancy; Munson Jeff; Korvatska Elena; Rodier Patricia M; Schellenberg Gerard D; Smith Moyra; Spence M Anne; Stodgell Chris; Tepper Ping Guo; Wijsman Ellen M; Yu Chang-En; Rogé Bernadette; Mantoulan Carine; Wittemeyer Kerstin; Poustka Annemarie; Felder Bärbel; Klauck Sabine M; Schuster Claudia; Poustka Fritz; Bölte Sven; Feineis-Matthews Sabine; Herbrecht Evelyn; Schmötzer Gabi; Tsiantis John; Papanikolaou Katerina; Maestrini Elena; Bacchelli Elena; Blasi Francesca; Carone Simona; Toma Claudio; Van Engeland Herman; de Jonge Maretha; Kemner Chantal; Koop Frederieke; Langemeijer Marjolein; Hijmans Channa; Staal Wouter G; Baird Gillian; Bolton Patrick F; Rutter Michael L; Weisblatt Emma; Green Jonathan; Aldred Catherine; Wilkinson Julie-Anne; Pickles Andrew; Le Couteur Ann; Berney Tom; McConachie Helen; Bailey Anthony J; Francis Kostas; Honeyman Gemma; Hutchinson Aislinn; Parr Jeremy R; Wallace Simon; Monaco Anthony P; Barnby Gabrielle; Kobayashi Kazuhiro; Lamb Janine A; Sousa Ines; Sykes Nuala; Cook Edwin H; Guter Stephen J; Leventhal Bennett L; Salt Jeff; Lord Catherine; Corsello Christina; Hus Vanessa; Weeks Daniel E; Volkmar Fred; Tauber Maïté; Fombonne Eric; Shih Andy; Meyer Kacie J
Mapping autism risk loci using genetic linkage and chromosomal rearrangements.
Nature genetics 2007;39(3):319-28.
2007: Kim Minji; Hersh Louis B; Leissring Malcolm A; Ingelsson Martin; Matsui Toshifumi; Farris Wesley; Lu Alice; Hyman Bradley T; Selkoe Dennis J; Bertram Lars; Tanzi Rudolph E
Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.
The Journal of biological chemistry 2007;282(11):7825-32.
2007: Perry Rodney T; Wiener Howard; Harrell Lindy E; Blacker Deborah; Tanzi Rudolph E; Bertram Lars; Bassett Susan S; Go Rodney C P
Follow-up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease Genetics Initiative cohort.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(2):220-7.
2007: Xie Zhongcong; Dong Yuanlin; Maeda Uta; Moir Robert D; Xia Weiming; Culley Deborah J; Crosby Gregory; Tanzi Rudolph E
The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(6):1247-54.
2007: Xie Zhongcong; Dong Yuanlin; Maeda Uta; Xia Weiming; Tanzi Rudolph E
RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation.
The Journal of biological chemistry 2007;282(7):4318-25.
2007: Bertram Lars; Mullin Kristina; Parkinson Michele; Hsiao Monica; Moscarillo Thomas J; Wagner Steven L; Becker K David; Velicelebi Gonul; Blacker Deborah; Tanzi Rudolph E
Is alpha-T catenin (VR22) an Alzheimer's disease risk gene?
Journal of medical genetics 2007;44(1):e63.
2007: Bertram Lars; McQueen Matthew B; Mullin Kristina; Blacker Deborah; Tanzi Rudolph E
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.
Nature genetics 2007;39(1):17-23.
2007: Bertram Lars; Hsiao Monica; McQueen Matthew B; Parkinson Michele; Mullin Kristina; Blacker Deborah; Tanzi Rudolph E
The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data.
Neurobiology of aging 2007;28(1):18.e1-4.
2007: Zhang Can; Khandelwal Preeti J; Chakraborty Ranjita; Cuellar Trinna L; Sarangi Srikant; Patel Shyam A; Cosentino Christopher P; O'Connor Michael; Lee Jeremy C; Tanzi Rudolph E; Saunders Aleister J
An AICD-based functional screen to identify APP metabolism regulators.
Molecular neurodegeneration 2007;2():15.
2006: Xie Zhongcong; Dong Yuanlin; Maeda Uta; Moir Robert; Inouye Sharon K; Culley Deborah J; Crosby Gregory; Tanzi Rudolph E
Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia.
The journals of gerontology. Series A, Biological sciences and medical sciences 2006;61(12):1300-6.
2006: Culley Deborah J; Yukhananov Rustam Y; Xie Zhongcong; Gali Reddy R; Tanzi Rudolph E; Crosby Gregory
Altered hippocampal gene expression 2 days after general anesthesia in rats.
European journal of pharmacology 2006;549(1-3):71-8.
2006: Hiltunen Mikko; Lu Alice; Thomas Anne V; Romano Donna M; Kim Minji; Jones Phill B; Xie Zhongcong; Kounnas Maria Z; Wagner Steven L; Berezovska Oksana; Hyman Bradley T; Tesco Giuseppina; Bertram Lars; Tanzi Rudolph E
Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.
The Journal of biological chemistry 2006;281(43):32240-53.
2006: Thomas Anne V; Herl Lauren; Spoelgen Robert; Hiltunen Mikko; Jones Phill B; Tanzi Rudolph E; Hyman Bradley T; Berezovska Oksana
Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader.
The Journal of biological chemistry 2006;281(36):26400-7.
2006: Bertram Lars; Hsiao Monica; Lange Christoph; Blacker Deborah; Tanzi Rudolph E
Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples.
American journal of human genetics 2006;79(1):180-3; author reply 183-4.
2006: Liu Guijian; Huang Weidong; Moir Robert D; Vanderburg Charles R; Lai Barry; Peng Zicheng; Tanzi Rudolph E; Rogers Jack T; Huang Xudong
Metal exposure and Alzheimer's pathogenesis.
Journal of structural biology 2006;155(1):45-51.
2006: Romano Donna M; Dong Yuanlin; Hiltunen Mikko; Tanzi Rudolph E; Xie Zhongcong
Artefactual effects of lipid-based cell transfection reagents on AbetaPP processing and Abeta production.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2006;13(2):86-92.
2006: Xie Zhongcong; Dong Yuanlin; Maeda Uta; Alfille Paul; Culley Deborah J; Crosby Gregory; Tanzi Rudolph E
The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels.
Anesthesiology 2006;104(5):988-94.
2006: Xie Zhongcong; Tanzi Rudolph E
Alzheimer's disease and post-operative cognitive dysfunction.
Experimental gerontology 2006;41(4):346-59.
2005: Bertram L; Parkinson M; McQueen M B; Mullin K; Hsiao M; Menon R; Moscarillo T J; Blacker D; Tanzi R E
Further evidence for LBP-1c/CP2/LSF association in Alzheimer's disease families.
Journal of medical genetics 2005;42(11):857-62.
2005: Tanzi Rudolph E
Tangles and neurodegenerative disease--a surprising twist.
The New England journal of medicine 2005;353(17):1853-5.
2005: Tesco Giuseppina; Ginestroni Andrea; Hiltunen Mikko; Kim Minji; Dolios Georgia; Hyman Bradley T; Wang Rong; Berezovska Oksana; Tanzi Rudolph E
APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation.
Journal of neurochemistry 2005;95(2):446-56.
2005: Koh Young Ho; von Arnim Christine A F; Hyman Bradley T; Tanzi Rudolph E; Tesco Giuseppina
BACE is degraded via the lysosomal pathway.
The Journal of biological chemistry 2005;280(37):32499-504.
2005: Dickerson B C; Salat D H; Greve D N; Chua E F; Rand-Giovannetti E; Rentz D M; Bertram L; Mullin K; Tanzi R E; Blacker D; Albert M S; Sperling R A
Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD.
Neurology 2005;65(3):404-11.
2005: Tanzi Rudolph E
The synaptic Abeta hypothesis of Alzheimer disease.
Nature neuroscience 2005;8(8):977-9.
2005: Bertram Lars; Tanzi Rudolph E
The genetic epidemiology of neurodegenerative disease.
The Journal of clinical investigation 2005;115(6):1449-57.
2005: Bertram L; Hsiao M; Mullin K; Parkinson M; Menon R; Moscarillo T J; Blacker D; Tanzi R E
ACAT1 is not associated with Alzheimer's disease in two independent family-based samples.
Molecular psychiatry 2005;10(6):522-4.
2005: Moir Robert D; Tanzi Rudolph E
LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP.
Current Alzheimer research 2005;2(2):269-73.
2005: Moir Robert D; Tseitlin Katya A; Soscia Stephanie; Hyman Bradley T; Irizarry Michael C; Tanzi Rudolph E
Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients.
The Journal of biological chemistry 2005;280(17):17458-63.
2005: Xie Zhongcong; Romano Donna M; Tanzi Rudolph E
RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing.
The Journal of biological chemistry 2005;280(15):15413-21.
2005: Bertram Lars; Hiltunen Mikko; Parkinson Michele; Ingelsson Martin; Lange Christoph; Ramasamy Karunya; Mullin Kristina; Menon Rashmi; Sampson Andrew J; Hsiao Monica Y; Elliott Kathryn J; Velicelebi Gonül; Moscarillo Thomas; Hyman Bradley T; Wagner Steven L; Becker K David; Blacker Deborah; Tanzi Rudolph E
Family-based association between Alzheimer's disease and variants in UBQLN1.
The New England journal of medicine 2005;352(9):884-94.
2005: Tanzi Rudolph E; Bertram Lars
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective.
Cell 2005;120(4):545-55.
2005: Xie Zhongcong; Romano Donna M; Tanzi Rudolph E
Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1.
Journal of molecular neuroscience : MN 2005;25(1):67-77.
2004: Huang Xudong; Atwood Craig S; Moir Robert D; Hartshorn Mariana A; Tanzi Rudolph E; Bush Ashley I
Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(8):954-60.
2004: Dedeoglu Alpaslan; Cormier Kerry; Payton Sandra; Tseitlin Katya A; Kremsky Jonathan N; Lai Li; Li Xiaohua; Moir Robert D; Tanzi Rudolph E; Bush Ashley I; Kowall Neil W; Rogers Jack T; Huang Xudong
Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis.
Experimental gerontology 2004;39(11-12):1641-9.
2004: Bertram Lars; Tanzi Rudolph E
The current status of Alzheimer's disease genetics: what do we tell the patients?
Pharmacological research : the official journal of the Italian Pharmacological Society 2004;50(4):385-96.
2004: Tanzi R E; Moir R D; Wagner S L
Clearance of Alzheimer's Abeta peptide: the many roads to perdition.
Neuron 2004;43(5):605-8.
2004: Xie Zhongcong; Romano Donna M; Kovacs Dora M; Tanzi Rudolph E
Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation.
The Journal of biological chemistry 2004;279(33):34130-7.
2004: Bertram L; Parkinson M; Mullin K; Menon R; Blacker D; Tanzi R E
No association between a previously reported OLR1 3' UTR polymorphism and Alzheimer's disease in a large family sample.
Journal of medical genetics 2004;41(4):286-8.
2004: Farris Wesley; Mansourian Stefan; Leissring Malcolm A; Eckman Elizabeth A; Bertram Lars; Eckman Christopher B; Tanzi Rudolph E; Selkoe Dennis J
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.
The American journal of pathology 2004;164(4):1425-34.
2004: Bertram Lars; Tanzi Rudolph E
Alzheimer's disease: one disorder, too many genes?
Human molecular genetics 2004;13 Spec No 1():R135-41.
2004: Nagano Seiichi; Huang Xudong; Moir Robert D; Payton Sandra M; Tanzi Rudolph E; Bush Ashley I
Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease.
The Journal of biological chemistry 2004;279(15):14673-8.
2004: Huang Xudong; Moir Robert D; Tanzi Rudolph E; Bush Ashley I; Rogers Jack T
Redox-active metals, oxidative stress, and Alzheimer's disease pathology.
Annals of the New York Academy of Sciences 2004;1012():153-63.
2004: Bertram L; Menon R; Mullin K; Parkinson M; Bradley M L; Blacker D; Tanzi R E
PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample.
Neurology 2004;62(2):304-6.
2004: Xie Zhongcong; Moir Robert D; Romano Donna M; Tesco Giuseppina; Kovacs Dora M; Tanzi Rudolph E
Hypocapnia induces caspase-3 activation and increases Abeta production.
Neuro-degenerative diseases 2004;1(1):29-37.
2003: Ritchie Craig W; Bush Ashley I; Mackinnon Andrew; Macfarlane Steve; Mastwyk Maree; MacGregor Lachlan; Kiers Lyn; Cherny Robert; Li Qiao-Xin; Tammer Amanda; Carrington Darryl; Mavros Christine; Volitakis Irene; Xilinas Michel; Ames David; Davis Stephen; Beyreuther Konrad; Tanzi Rudolph E; Masters Colin L
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.
Archives of neurology 2003;60(12):1685-91.
2003: Chang Yang; Tesco Giuseppina; Jeong William J; Lindsley Loren; Eckman Elizabeth A; Eckman Christopher B; Tanzi Rudolph E; Guénette Suzanne Y
Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.
The Journal of biological chemistry 2003;278(51):51100-7.
2003: Saunders Aleister J; Tanzi Rudolph E
Welcome to the complex disease world. Alpha2-macroglobulin and Alzheimer's disease.
Experimental neurology 2003;184(1):50-3.
2003: Saunders Aleister J; Bertram Lars; Mullin Kristina; Sampson Andrew J; Latifzai Khushal; Basu Sanjay; Jones Jennifer; Kinney Devon; MacKenzie-Ingano Laura; Yu Stephen; Albert Marilyn S; Moscarillo Thomas J; Go Rodney C P; Bassett Susan S; Daly Mark J; Laird Nan M; Wang Xin; Velicelebi Gonul; Wagner Steven L; Becker David K; Tanzi Rudolph E; Blacker Deborah
Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin.
Human molecular genetics 2003;12(21):2765-76.
2003: Tesco Giuseppina; Koh Young Ho; Tanzi Rudolph E
Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP).
The Journal of biological chemistry 2003;278(46):46074-80.
2003: Bush Ashley I; Masters Colin L; Tanzi Rudolph E
Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11193-4.
2003: Bertram L; Saunders A J; Mullin K; Sampson A; Moscarillo T J; Basset S S; Go R C P; Blacker D; Tanzi R E
No association between marker D10S1423 and Alzheimer's disease.
Molecular psychiatry 2003;8(6):571-3.
2003: Goldstein Lee E; Muffat Julien A; Cherny Robert A; Moir Robert D; Ericsson Maria H; Huang Xudong; Mavros Christine; Coccia Jennifer A; Faget Kyle Y; Fitch Karlotta A; Masters Colin L; Tanzi Rudolph E; Chylack Leo T; Bush Ashley I
Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease.
Lancet 2003;361(9365):1258-65.
2003: Puglielli Luigi; Tanzi Rudolph E; Kovacs Dora M
Alzheimer's disease: the cholesterol connection.
Nature neuroscience 2003;6(4):345-51.
2003: Farris Wesley; Mansourian Stefan; Chang Yang; Lindsley Loren; Eckman Elizabeth A; Frosch Matthew P; Eckman Christopher B; Tanzi Rudolph E; Selkoe Dennis J; Guenette Suzanne
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4162-7.
2003: Blacker Deborah; Bertram Lars; Saunders Aleister J; Moscarillo Thomas J; Albert Marilyn S; Wiener Howard; Perry Rodney T; Collins Julianne S; Harrell Lindy E; Go Rodney C P; Mahoney Amy; Beaty Terri; Fallin M Danielle; Avramopoulos Dimitrios; Chase Gary A; Folstein Marshal F; McInnis Melvin G; Bassett Susan S; Doheny Kimberly J; Pugh Elizabeth W; Tanzi Rudolph E;
Results of a high-resolution genome screen of 437 Alzheimer's disease families.
Human molecular genetics 2003;12(1):23-32.
2002: Rogers Jack T; Randall Jeffrey D; Cahill Catherine M; Eder Paul S; Huang Xudong; Gunshin Hiromi; Leiter Lorene; McPhee Jay; Sarang Satinder S; Utsuki Tada; Greig Nigel H; Lahiri Debomoy K; Tanzi Rudolph E; Bush Ashley I; Giordano Tony; Gullans Steve R
An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript.
The Journal of biological chemistry 2002;277(47):45518-28.
2002: Opazo Carlos; Huang Xudong; Cherny Robert A; Moir Robert D; Roher Alex E; White Anthony R; Cappai Roberto; Masters Colin L; Tanzi Rudolph E; Inestrosa Nibaldo C; Bush Ashley I
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
The Journal of biological chemistry 2002;277(43):40302-8.
2002: Guénette Suzanne Y; Chang Yang; Hyman Bradley T; Tanzi Rudolph E; Rebeck G William
Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1.
Journal of neurochemistry 2002;82(4):755-62.
2002: Rogers Jack T; Randall Jeffrey D; Eder Paul S; Huang Xudong; Bush Ashley I; Tanzi Rudolph E; Venti Amanda; Payton Sandra M; Giordano Tony; Nagano Seiichi; Cahill Catherine M; Moir Robert; Lahiri Debomoy K; Greig Nigel; Sarang Satinder Singh; Gullans Steven R
Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region.
Journal of molecular neuroscience : MN 2002;19(1-2):77-82.
2002: Goto Joy J; Tanzi Rudolph E
The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system.
Journal of molecular neuroscience : MN 2002;19(1-2):37-41.
2002: Bush Ashley I; Tanzi Rudolph E
The galvanization of beta-amyloid in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7317-9.
2002: Killiany R J; Hyman B T; Gomez-Isla T; Moss M B; Kikinis R; Jolesz F; Tanzi R; Jones K; Albert M S
MRI measures of entorhinal cortex vs hippocampus in preclinical AD.
Neurology 2002;58(8):1188-96.
2001: Bertram L; Tanzi R E
Dancing in the dark? The status of late-onset Alzheimer's disease genetics.
Journal of molecular neuroscience : MN 2001;17(2):127-36.
2001: Tanzi R E; Bertram L
New frontiers in Alzheimer's disease genetics.
Neuron 2001;32(2):181-4.
2001: Puglielli L; Konopka G; Pack-Chung E; Ingano L A; Berezovska O; Hyman B T; Chang T Y; Tanzi R E; Kovacs D M
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide.
Nature cell biology 2001;3(10):905-12.
2001: Bertram L; Tanzi R E
Of replications and refutations: the status of Alzheimer's disease genetic research.
Current neurology and neuroscience reports 2001;1(5):442-50.
2001: Albert M S; Moss M B; Tanzi R; Jones K
Preclinical prediction of AD using neuropsychological tests.
Journal of the International Neuropsychological Society : JINS 2001;7(5):631-9.
2001: Cherny R A; Atwood C S; Xilinas M E; Gray D N; Jones W D; McLean C A; Barnham K J; Volitakis I; Fraser F W; Kim Y; Huang X; Goldstein L E; Moir R D; Lim J T; Beyreuther K; Zheng H; Tanzi R E; Masters C L; Bush A I
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
Neuron 2001;30(3):665-76.
2001: Kim J W; Chang T S; Lee J E; Huh S H; Yeon S W; Yang W S; Joe C O; Mook-Jung I; Tanzi R E; Kim T W; Choi E J
Negative regulation of the SAPK/JNK signaling pathway by presenilin 1.
The Journal of cell biology 2001;153(3):457-63.
2001: Tanaka Y; Engelender S; Igarashi S; Rao R K; Wanner T; Tanzi R E; Sawa A; L Dawson V; Dawson T M; Ross C A
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis.
Human molecular genetics 2001;10(9):919-26.
2001: Rebeck G W; Moir R D; Mui S; Strickland D K; Tanzi R E; Hyman B T
Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP.
Brain research. Molecular brain research 2001;87(2):238-45.
2001: Bertram L; Guénette S; Jones J; Keeney D; Mullin K; Crystal A; Basu S; Yhu S; Deng A; Rebeck G W; Hyman B T; Go R; McInnis M; Blacker D; Tanzi R
No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease.
Annals of neurology 2001;49(1):114-6.
2000: Bertram L; Blacker D; Mullin K; Keeney D; Jones J; Basu S; Yhu S; McInnis M G; Go R C; Vekrellis K; Selkoe D J; Saunders A J; Tanzi R E
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.
Science (New York, N.Y.) 2000;290(5500):2302-3.
2000: Collins J S; Perry R T; Watson B; Harrell L E; Acton R T; Blacker D; Albert M S; Tanzi R E; Bassett S S; McInnis M G; Campbell R D; Go R C
Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative.
American journal of medical genetics 2000;96(6):823-30.
2000: Bertram L; Blacker D; Crystal A; Mullin K; Keeney D; Jones J; Basu S; Yhu S; Guénette S; McInnis M; Go R; Tanzi R
Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies.
Experimental gerontology 2000;35(9-10):1353-61.
2000: Liu Y; Jones M; Hingtgen C M; Bu G; Laribee N; Tanzi R E; Moir R D; Nath A; He J J
Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands.
Nature medicine 2000;6(12):1380-7.
2000: Guénette S Y; Bertram L; Crystal A; Bakondi B; Hyman B T; Rebeck G W; Tanzi R E; Blacker D
Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients.
Neuroscience letters 2000;296(1):17-20.
2000: Buxbaum J D; Lilliehook C; Chan J Y; Go R C; Bassett S S; Tanzi R E; Wasco W; Blacker D
Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease.
Neuroscience letters 2000;294(3):135-8.
2000: Yoo A S; Cheng I; Chung S; Grenfell T Z; Lee H; Pack-Chung E; Handler M; Shen J; Xia W; Tesco G; Saunders A J; Ding K; Frosch M P; Tanzi R E; Kim T W
Presenilin-mediated modulation of capacitative calcium entry.
Neuron 2000;27(3):561-72.
2000: Atwood C S; Scarpa R C; Huang X; Moir R D; Jones W D; Fairlie D P; Tanzi R E; Bush A I
Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42.
Journal of neurochemistry 2000;75(3):1219-33.
2000: Sawamura N; Morishima-Kawashima M; Waki H; Kobayashi K; Kuramochi T; Frosch M P; Ding K; Ito M; Kim T W; Tanzi R E; Oyama F; Tabira T; Ando S; Ihara Y
Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin.
The Journal of biological chemistry 2000;275(36):27901-8.
2000: Tanzi R E
Alzheimer's disease and related dementias: the road to intervention.
Experimental gerontology 2000;35(4):433-7.
2000: Cherny R A; Barnham K J; Lynch T; Volitakis I; Li Q X; McLean C A; Multhaup G; Beyreuther K; Tanzi R E; Masters C L; Bush A I
Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.
Journal of structural biology 2000;130(2-3):209-16.
2000: Atwood C S; Huang X; Khatri A; Scarpa R C; Kim Y S; Moir R D; Tanzi R E; Roher A E; Bush A I
Copper catalyzed oxidation of Alzheimer Abeta.
Cellular and molecular biology (Noisy-le-Grand, France) 2000;46(4):777-83.
2000: Goldstein L E; Leopold M C; Huang X; Atwood C S; Saunders A J; Hartshorn M; Lim J T; Faget K Y; Muffat J A; Scarpa R C; Chylack L T; Bowden E F; Tanzi R E; Bush A I
3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction.
Biochemistry 2000;39(24):7266-75.
2000: Huang X; Cuajungco M P; Atwood C S; Moir R D; Tanzi R E; Bush A I
Alzheimer's disease, beta-amyloid protein and zinc.
The Journal of nutrition 2000;130(5S Suppl):1488S-92S.
2000: Pack-Chung E; Meyers M B; Pettingell W P; Moir R D; Brownawell A M; Cheng I; Tanzi R E; Kim T W
Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor.
The Journal of biological chemistry 2000;275(19):14440-5.
2000: Killiany R J; Gomez-Isla T; Moss M; Kikinis R; Sandor T; Jolesz F; Tanzi R; Jones K; Hyman B T; Albert M S
Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease.
Annals of neurology 2000;47(4):430-9.
2000: Tanzi R E
Alzheimer's disease risk and the interleukin-1 genes.
Annals of neurology 2000;47(3):283-5.
2000: Ulery P G; Beers J; Mikhailenko I; Tanzi R E; Rebeck G W; Hyman B T; Strickland D K
Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.
The Journal of biological chemistry 2000;275(10):7410-5.
2000: Abbenante G; Kovacs D M; Leung D L; Craik D J; Tanzi R E; Fairlie D P
Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site.
Biochemical and biophysical research communications 2000;268(1):133-5.
2000: Cuajungco M P; Fagét K Y; Huang X; Tanzi R E; Bush A I
Metal chelation as a potential therapy for Alzheimer's disease.
Annals of the New York Academy of Sciences 2000;920():292-304.
2000: Ingano L A; Lentini K M; Kovacs I; Tanzi R E; Kovacs D M
Cytoplasmic presenilin aggregates in proteasome inhibitor-treated cells.
Annals of the New York Academy of Sciences 2000;920():259-60.
2000: Tesco G; Tanzi R E
GSK3 beta forms a tetrameric complex with endogenous PS1-CTF/NTF and beta-catenin. Effects of the D257/D385A and FAD-linked mutations.
Annals of the New York Academy of Sciences 2000;920():227-32.
1999: Huang X; Cuajungco M P; Atwood C S; Hartshorn M A; Tyndall J D; Hanson G R; Stokes K C; Leopold M; Multhaup G; Goldstein L E; Scarpa R C; Saunders A J; Lim J; Moir R D; Glabe C; Bowden E F; Masters C L; Fairlie D P; Tanzi R E; Bush A I
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.
The Journal of biological chemistry 1999;274(52):37111-6.
1999: Kovacs D M; Mancini R; Henderson J; Na S J; Schmidt S D; Kim T W; Tanzi R E
Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells.
Journal of neurochemistry 1999;73(6):2278-85.
1999: Tanzi R E
A genetic dichotomy model for the inheritance of Alzheimer's disease and common age-related disorders.
The Journal of clinical investigation 1999;104(9):1175-9.
1999: Guénette S Y; Chen J; Ferland A; Haass C; Capell A; Tanzi R E
hFE65L influences amyloid precursor protein maturation and secretion.
Journal of neurochemistry 1999;73(3):985-93.
1999: Cherny R A; Legg J T; McLean C A; Fairlie D P; Huang X; Atwood C S; Beyreuther K; Tanzi R E; Masters C L; Bush A I
Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.
The Journal of biological chemistry 1999;274(33):23223-8.
1999: Moir R D; Atwood C S; Huang X; Tanzi R E; Bush A I
Mounting evidence for the involvement of zinc and copper in Alzheimer's disease.
European journal of clinical investigation 1999;29(7):569-70.
1999: Tanzi R E
Caspases land on APP: one small step for apoptosis, one giant leap for amyloidosis?
Nature neuroscience 1999;2(7):585-6.
1999: Huang X; Atwood C S; Hartshorn M A; Multhaup G; Goldstein L E; Scarpa R C; Cuajungco M P; Gray D N; Lim J; Moir R D; Tanzi R E; Bush A I
The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction.
Biochemistry 1999;38(24):7609-16.
1999: Moir R D; Atwood C S; Romano D M; Laurans M H; Huang X; Bush A I; Smith J D; Tanzi R E
Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations.
Biochemistry 1999;38(14):4595-603.
1999: Guénette S Y; Tanzi R E
Progress toward valid transgenic mouse models for Alzheimer's disease.
Neurobiology of aging 1999;20(2):201-11.
1999: Atwood C S; Huang X; Moir R D; Tanzi R E; Bush A I
Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease.
Metal ions in biological systems 1999;36():309-64.
1998: Tesco G; Kim T W; Diehlmann A; Beyreuther K; Tanzi R E
Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation.
The Journal of biological chemistry 1998;273(51):33909-14.
1998: Liao A; Nitsch R M; Greenberg S M; Finckh U; Blacker D; Albert M; Rebeck G W; Gomez-Isla T; Clatworthy A; Binetti G; Hock C; Mueller-Thomsen T; Mann U; Zuchowski K; Beisiegel U; Staehelin H; Growdon J H; Tanzi R E; Hyman B T
Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.
Human molecular genetics 1998;7(12):1953-6.
1998: Kim T W; Tanzi R E
Neuronal intranuclear inclusions in polyglutamine diseases: nuclear weapons or nuclear fallout?
Neuron 1998;21(4):657-9.
1998: Tanzi R E
Of calcium, caspases, and cognitive decline.
Nature medicine 1998;4(10):1127-8.
1998: Kovacs D M; Tanzi R E
Monogenic determinants of familial Alzheimer's disease: presenilin-1 mutations.
Cellular and molecular life sciences : CMLS 1998;54(9):902-9.
1998: Bush A I; Tanzi R E
Alzheimer disease-related abnormalities of amyloid beta precursor protein isoforms in the platelet: the brain's delegate in the periphery?
Archives of neurology 1998;55(9):1179-80.
1998: McNamara M J; Ruff C T; Wasco W; Tanzi R E; Thinakaran G; Hyman B T
Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains.
Brain research 1998;804(1):45-51.
1998: Blacker D; Wilcox M A; Laird N M; Rodes L; Horvath S M; Go R C; Perry R; Watson B; Bassett S S; McInnis M G; Albert M S; Hyman B T; Tanzi R E
Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
Nature genetics 1998;19(4):357-60.
1998: Etcheberrigaray R; Hirashima N; Nee L; Prince J; Govoni S; Racchi M; Tanzi R E; Alkon D L
Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families.
Neurobiology of disease 1998;5(1):37-45.
1998: Xia M Q; Berezovska O; Kim T W; Xia W M; Liao A; Tanzi R E; Selkoe D; Hyman B T
Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease.
Journal of the neurological sciences 1998;158(1):15-23.
1998: Atwood C S; Moir R D; Huang X; Scarpa R C; Bacarra N M; Romano D M; Hartshorn M A; Tanzi R E; Bush A I
Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.
The Journal of biological chemistry 1998;273(21):12817-26.
1998: Blacker D; Tanzi R E
The genetics of Alzheimer disease: current status and future prospects.
Archives of neurology 1998;55(3):294-6.
1998: Moir R D; Lynch T; Bush A I; Whyte S; Henry A; Portbury S; Multhaup G; Small D H; Tanzi R E; Beyreuther K; Masters C L
Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain.
The Journal of biological chemistry 1998;273(9):5013-9.
1998: Price D L; Tanzi R E; Borchelt D R; Sisodia S S
Alzheimer's disease: genetic studies and transgenic models.
Annual review of genetics 1998;32():461-93.
1998: Hock C; Golombowski S; Müller-Spahn F; Naser W; Beyreuther K; Mönning U; Schenk D; Vigo-Pelfrey C; Bush A M; Moir R; Tanzi R E; Growdon J H; Nitsch R M
Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity.
European neurology 1998;39(2):111-8.
1997: Kim T W; Tanzi R E
Presenilins and Alzheimer's disease.
Current opinion in neurobiology 1997;7(5):683-8.
1997: Finch C E; Tanzi R E
Genetics of aging.
Science (New York, N.Y.) 1997;278(5337):407-11.
1997: Huang X; Atwood C S; Moir R D; Hartshorn M A; Vonsattel J P; Tanzi R E; Bush A I
Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.
The Journal of biological chemistry 1997;272(42):26464-70.
1997: Kim T W; Pettingell W H; Jung Y K; Kovacs D M; Tanzi R E
Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease.
Science (New York, N.Y.) 1997;277(5324):373-6.
1997: Gómez-Isla T; Wasco W; Pettingell W P; Gurubhagavatula S; Schmidt S D; Jondro P D; McNamara M; Rodes L A; DiBlasi T; Growdon W B; Seubert P; Schenk D; Growdon J H; Hyman B T; Tanzi R E
A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes.
Annals of neurology 1997;41(6):809-13.
1997: Seeger M; Nordstedt C; Petanceska S; Kovacs D M; Gouras G K; Hahne S; Fraser P; Levesque L; Czernik A J; George-Hyslop P S; Sisodia S S; Thinakaran G; Tanzi R E; Greengard P; Gandy S
Evidence for phosphorylation and oligomeric assembly of presenilin 1.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5090-4.
1997: Kim T W; Pettingell W H; Hallmark O G; Moir R D; Wasco W; Tanzi R E
Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells.
The Journal of biological chemistry 1997;272(17):11006-10.
1997: Suzuki T; Ando K; Isohara T; Oishi M; Lim G S; Satoh Y; Wasco W; Tanzi R E; Nairn A C; Greengard P; Gandy S E; Kirino Y
Phosphorylation of Alzheimer beta-amyloid precursor-like proteins.
Biochemistry 1997;36(15):4643-9.
1997: Blacker D; Haines J L; Rodes L; Terwedow H; Go R C; Harrell L E; Perry R T; Bassett S S; Chase G; Meyers D; Albert M S; Tanzi R
ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative.
Neurology 1997;48(1):139-47.
1997: Berezovska O; Xia M Q; Page K; Wasco W; Tanzi R E; Hyman B T
Developmental regulation of presenilin mRNA expression parallels notch expression.
Journal of neuropathology and experimental neurology 1997;56(1):40-4.
1996: Page K; Hollister R; Tanzi R E; Hyman B T
In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):14020-4.
1996: Guénette S Y; Chen J; Jondro P D; Tanzi R E
Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10832-7.
1996: Cook D G; Sung J C; Golde T E; Felsenstein K M; Wojczyk B S; Tanzi R E; Trojanowski J Q; Lee V M; Doms R W
Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9223-8.
1996: Irizarry M C; Kim T W; McNamara M; Tanzi R E; George J M; Clayton D F; Hyman B T
Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system.
Journal of neuropathology and experimental neurology 1996;55(8):889-95.
1996: Scheuner D; Eckman C; Jensen M; Song X; Citron M; Suzuki N; Bird T D; Hardy J; Hutton M; Kukull W; Larson E; Levy-Lahad E; Viitanen M; Peskind E; Poorkaj P; Schellenberg G; Tanzi R; Wasco W; Lannfelt L; Selkoe D; Younkin S
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
Nature medicine 1996;2(8):864-70.
1996: Kovacs D M; Fausett H J; Page K J; Kim T W; Moir R D; Merriam D E; Hollister R D; Hallmark O G; Mancini R; Felsenstein K M; Hyman B T; Tanzi R E; Wasco W
Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.
Nature medicine 1996;2(2):224-9.
1996: Tanzi R E
Neuropathology in the Down's syndrome brain.
Nature medicine 1996;2(1):31-2.
1996: Tanzi R E; Kovacs D M; Kim T W; Moir R D; Guenette S Y; Wasco W
The gene defects responsible for familial Alzheimer's disease.
Neurobiology of disease 1996;3(3):159-68.
1995: Hyman B T; Tanzi R
Molecular epidemiology of Alzheimer's disease.
The New England journal of medicine 1995;333(19):1283-4.
1995: Kovacs D M; Wasco W; Witherby J; Felsenstein K M; Brunel F; Roeder R G; Tanzi R E
The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene.
Human molecular genetics 1995;4(9):1527-33.
1995: Webster M T; Groome N; Francis P T; Pearce B R; Sherriff F E; Thinakaran G; Felsenstein K M; Wasco W; Tanzi R E; Bowen D M
A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media.
The Biochemical journal 1995;310 ( Pt 1)():95-9.
1995: Kim T W; Wu K; Xu J L; McAuliffe G; Tanzi R E; Wasco W; Black I B
Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density.
Brain research. Molecular brain research 1995;32(1):36-44.
1995: Corder E H; Saunders A M; Strittmatter W J; Schmechel D E; Gaskell P C; Rimmler J B; Locke P A; Conneally P M; Schmader K E; Tanzi R E
Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease.
Neurology 1995;45(7):1323-8.
1995: Kounnas M Z; Moir R D; Rebeck G W; Bush A I; Argraves W S; Tanzi R E; Hyman B T; Strickland D K
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation.
Cell 1995;82(2):331-40.
1995: Tanzi R E
A promising animal model of Alzheimer's disease.
The New England journal of medicine 1995;332(22):1512-3.
1995: Locke P A; Conneally P M; Tanzi R E; Gusella J F; Haines J L
Apolipoprotein E4 allele and Alzheimer disease: examination of allelic association and effect on age at onset in both early- and late-onset cases.
Genetic epidemiology 1995;12(1):83-92.
1994: Gregor P; Gaston S M; Yang X; O'Regan J P; Rosen D R; Tanzi R E; Patterson D; Haines J L; Horvitz H R; Uhl G R
Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21.
Human genetics 1994;94(5):565-70.
1994: Bush A I; Pettingell W H; de Paradis M; Tanzi R E; Wasco W
The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily.
The Journal of biological chemistry 1994;269(43):26618-21.
1994: Muramatsu Y; Yamada T; Miura M; Sakai T; Suzuki Y; Serikawa T; Tanzi R E; Matsumoto K
Wilson's disease gene is homologous to hts causing abnormal copper transport in Long-Evans cinnamon rats.
Gastroenterology 1994;107(4):1189-92.
1994: Bush A I; Pettingell W H; Multhaup G; d Paradis M; Vonsattel J P; Gusella J F; Beyreuther K; Masters C L; Tanzi R E
Rapid induction of Alzheimer A beta amyloid formation by zinc.
Science (New York, N.Y.) 1994;265(5177):1464-7.
1994: Cai X; Szabo P; Ali G; Tanzi R E; Blass J P
Pseudogene of dihydrolipoyl succinyltransferase (E2k) found by PCR amplification and direct sequencing of rodent-human cell hybrid DNAs.
Somatic cell and molecular genetics 1994;20(4):339-43.
1994: Bush A I; Pettingell W H; Paradis M D; Tanzi R E
Modulation of A beta adhesiveness and secretase site cleavage by zinc.
The Journal of biological chemistry 1994;269(16):12152-8.
1994: Ali G; Wasco W; Cai X; Szabo P; Sheu K F; Cooper A J; Gaston S M; Gusella J F; Tanzi R E; Blass J P
Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex.
Somatic cell and molecular genetics 1994;20(2):99-105.
1994: Slunt H H; Thinakaran G; Von Koch C; Lo A C; Tanzi R E; Sisodia S S
Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).
The Journal of biological chemistry 1994;269(4):2637-44.
1994: Tanzi R E; Bush A I; Wasco W
Genetic studies of Alzheimer's disease: lessons learned and future imperatives.
Neurobiology of aging 1994;15 Suppl 2():S145-8.
1993: Tanzi R E; Petrukhin K; Chernov I; Pellequer J L; Wasco W; Ross B; Romano D M; Parano E; Pavone L; Brzustowicz L M
The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene.
Nature genetics 1993;5(4):344-50.
1993: Petrukhin K; Fischer S G; Pirastu M; Tanzi R E; Chernov I; Devoto M; Brzustowicz L M; Cayanis E; Vitale E; Russo J J
Mapping, cloning and genetic characterization of the region containing the Wilson disease gene.
Nature genetics 1993;5(4):338-43.
1993: Wasco W; Peppercorn J; Tanzi R E
Search for the genes responsible for familial Alzheimer's disease.
Annals of the New York Academy of Sciences 1993;695():203-8.
1993: Wasco W; Gurubhagavatula S; Paradis M D; Romano D M; Sisodia S S; Hyman B T; Neve R L; Tanzi R E
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor.
Nature genetics 1993;5(1):95-100.
1993: Tanzi R E; Wenniger J J; Hyman B T
Cellular specificity and regional distribution of amyloid beta protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation.
Brain research. Molecular brain research 1993;18(3):246-52.
1993: Hyman B T; Wenniger J J; Tanzi R E
Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques.
Brain research. Molecular brain research 1993;18(3):253-8.
1993: Wasco W; Brook J D; Tanzi R E
The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19.
Genomics 1993;15(1):237-9.
1993: Locke P A; MacDonald M E; Srinidhi J; Gilliam T C; Tanzi R E; Conneally P M; Wexler N S; Haines J L; Gusella J F
A genetic linkage map of the chromosome 4 short arm.
Somatic cell and molecular genetics 1993;19(1):95-101.
1993: Pericak-Vance M A; St George-Hyslop P H; Gaskell P C; Growdon J; Crain B J; Hulette C; Gusella J F; Yamaoka L; Tanzi R E; Roses A D
Linkage analysis in familial Alzheimer disease: description of the Duke and Boston data sets.
Genetic epidemiology 1993;10(6):361-4.
1993: Tanzi R; Gaston S; Bush A; Romano D; Pettingell W; Peppercorn J; Paradis M; Gurubhagavatula S; Jenkins B; Wasco W
Genetic heterogeneity of gene defects responsible for familial Alzheimer disease.
Genetica 1993;91(1-3):255-63.
1992: Wasco W; Bupp K; Magendantz M; Gusella J F; Tanzi R E; Solomon F
Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10758-62.
1992: Tanzi R E; Romano D M; Berger R; Buraczynska M J; Gaston S M; Kurnit D M; Patterson D; Gusella J F; Stewart G D
Sequence-tagged sites (STSs) for a set of mapped markers on chromosome 21.
Genomics 1992;14(2):498-502.
1992: Vaula G; Mortilla M; Tupler R; Lukiw W; Tanzi R; Nee L; Polinsky R; Foncin J F; Bruni A C; Montesi M P
A novel but non-pathogenic mutation in exon 4 of the human amyloid precursor protein (APP) gene.
Neuroscience letters 1992;144(1-2):46-8.
1992: Tanzi R E; Vaula G; Romano D M; Mortilla M; Huang T L; Tupler R G; Wasco W; Hyman B T; Haines J L; Jenkins B J
Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases.
American journal of human genetics 1992;51(2):273-82.
1992: Fidani L; Rooke K; Chartier-Harlin M C; Hughes D; Tanzi R; Mullan M; Roques P; Rossor M; Hardy J; Goate A
Screening for mutations in the open reading frame and promoter of the beta-amyloid precursor protein gene in familial Alzheimer's disease: identification of a further family with APP717 Val-->Ile.
Human molecular genetics 1992;1(3):165-8.
1992: Tanzi R E; Watkins P C; Stewart G D; Wexler N S; Gusella J F; Haines J L
A genetic linkage map of human chromosome 21: analysis of recombination as a function of sex and age.
American journal of human genetics 1992;50(3):551-8.
1992: Hyman B T; Tanzi R E
Amyloid, dementia and Alzheimer's disease.
Current opinion in neurology and neurosurgery 1992;5(1):88-93.
1992: Hyman B T; Tanzi R E; Marzloff K; Barbour R; Schenk D
Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease.
Journal of neuropathology and experimental neurology 1992;51(1):76-83.
1992: Haines J L; Trofatter J A; Tanzi R E; Watkins P; Wexler N S; Conneally P M; Gusella J F
Chromosome 21 genetic linkage data set based on the Venezuelan reference pedigree.
Cytogenetics and cell genetics 1992;59(2-3):88-9.
1991: Tanzi R E; George-Hyslop P S; Gusella J F
Molecular genetics of Alzheimer disease amyloid.
The Journal of biological chemistry 1991;266(31):20579-82.
1991: Tanzi R E
Genetic linkage studies of human neurodegenerative disorders.
Current opinion in neurobiology 1991;1(3):455-61.
1991: Tanzi R E
Gene mutations in inherited amyloidopathies of the nervous system.
American journal of human genetics 1991;49(3):507-10.
1991: Abe K; Tanzi R E; Kogure K
Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex.
Neuroscience letters 1991;125(2):172-4.
1991: Abe K; Tanzi R E; Kogure K
Induction of HSP70 mRNA after transient ischemia in gerbil brain.
Neuroscience letters 1991;125(2):166-8.
1991: Tanzi R E; Hyman B T
Alzheimer's mutation.
Nature 1991;350(6319):564.
1991: Abe K; St George-Hyslop P H; Tanzi R E; Kogure K
Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells.
Neuroscience letters 1991;125(2):169-71.
1991: Tanzi R E; Hyman B T
Studies of amyloid beta-protein precursor expression in Alzheimer's disease.
Annals of the New York Academy of Sciences 1991;640():149-54.
1990: Lerner T J; Arn E; Anderson M A; Klinger K W; Callen D F; Tanzi R E
Two RFLPs detected by a cosmid at locus D16S144.
Nucleic acids research 1990;18(16):4962.
1990: Tanzi R E; Haines J L; Gusella J F
Detailed genetic linkage map of human chromosome 21: patterns of recombination according to age and sex.
Progress in clinical and biological research 1990;360():15-26.
1990: Tanzi R E
The Alzheimer disease-associated amyloid beta protein precursor gene and familial Alzheimer disease.
Progress in clinical and biological research 1990;360():187-99.
1990: Palmert M R; Podlisny M B; Golde T E; Cohen M L; Kovacs D M; Tanzi R E; Gusella J F; Whitehouse P J; Witker D S; Oltersdorf T
Analysis of the beta-amyloid protein precursor of Alzheimer's disease: mRNAs and protein products.
Advances in neurology 1990;51():181-4.
1989: St George-Hyslop P H; Haines J L; Polinsky R J; Tanzi R E; Farrer L; Myers R H; Gusella J F
Molecular genetics of familial Alzheimer's disease.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1989;16(4 Suppl):465-7.
1989: St George-Hyslop P H; Myers R H; Haines J L; Farrer L A; Tanzi R E; Abe K; James M F; Conneally P M; Polinsky R J; Gusella J F
Familial Alzheimer's disease: progress and problems.
Neurobiology of aging 1989;10(5):417-25.
1989: Conneally P M; Haines J L; Tanzi R E; Wexler N S; Penchaszadeh G K; Harper P S; Folstein S E; Cassiman J J; Myers R H; Young A B
Huntington disease: no evidence for locus heterogeneity.
Genomics 1989;5(2):304-8.
1989: Van Keuren M L; Stewart G D; Bradley C M; Kurnit D M; Neve R L; Watkins P C; Tanzi R E; Gusella J F; Patterson D
Characterization of an unusual and complex chromosome 21 rearrangement using somatic cell genetics and cloned DNA probes.
American journal of medical genetics 1989;33(3):369-75.
1989: Tanzi R E; St George-Hyslop P H; Gusella J F
Molecular genetic approaches to Alzheimer's disease.
Trends in neurosciences 1989;12(4):152-8.
1989: St George-Hyslop P H; Tanzi R E; Haines J L; Polinsky R J; Farrer L; Myers R H; Gusella J F
Molecular genetics of familial Alzheimer's disease.
European neurology 1989;29 Suppl 3():25-7.
1989: Palmert M R; Podlisny M B; Golde T E; Cohen M L; Kovacs D M; Tanzi R E; Gusella J F; Whitehouse P J; Witker D S; Oltersdorf T
The beta amyloid protein precursor: mRNAs, membrane-associated forms, and soluble derivatives.
Progress in clinical and biological research 1989;317():971-84.
1989: Tanzi R E
Molecular genetics of Alzheimer's disease and the amyloid beta peptide precursor gene.
Annals of medicine 1989;21(2):91-4.
1988: Patterson D; Gardiner K; Kao F T; Tanzi R; Watkins P; Gusella J F
Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(21):8266-70.
1988: Phelan M C; Morton C C; Stevenson R E; Tanzi R E; Stewart G D; Watkins P C; Gusella J F; Amos J A
Molecular and cytogenetic characterization of a de novo t(5p;21q) in a patient previously diagnosed as monosomy 21.
American journal of human genetics 1988;43(4):511-9.
1988: Sacchi N; Cheng S V; Tanzi R E; Gusella J F; Drabkin H A; Patterson D; Haines J H; Papas T S
The ETS genes on chromosome 21 are distal to the breakpoint of the acute myelogenous leukemia translocation (8;21).
Genomics 1988;3(2):110-6.
1988: Tanzi R E; Haines J L; Watkins P C; Stewart G D; Wallace M R; Hallewell R; Wong C; Wexler N S; Conneally P M; Gusella J F
Genetic linkage map of human chromosome 21.
Genomics 1988;3(2):129-36.
1988: Cheng S V; Nadeau J H; Tanzi R E; Watkins P C; Jagadesh J; Taylor B A; Haines J L; Sacchi N; Gusella J F
Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):6032-6.
1988: Palmert M R; Golde T E; Cohen M L; Kovacs D M; Tanzi R E; Gusella J F; Usiak M F; Younkin L H; Younkin S G
Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease.
Science (New York, N.Y.) 1988;241(4869):1080-4.
1988: Graw S; Davidson J; Gusella J; Watkins P; Tanzi R; Neve R; Patterson D
Irradiation-reduced human chromosome 21 hybrids.
Somatic cell and molecular genetics 1988;14(3):233-42.
1988: Stewart G D; Hassold T J; Berg A; Watkins P; Tanzi R; Kurnit D M
Trisomy 21 (Down syndrome): studying nondisjunction and meiotic recombination by using cytogenetic and molecular polymorphisms that span chromosome 21.
American journal of human genetics 1988;42(2):227-36.
1988: Tanzi R E; McClatchey A I; Lamperti E D; Villa-Komaroff L; Gusella J F; Neve R L
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.
Nature 1988;331(6156):528-30.
1987: Cheng S V; Gross Lugo T; Tanzi R E; Whitney J B; Fournier R E; Gusella J F
Chromosomal localization of the mouse homolog of the Huntington's disease linked G8 (D4S10) marker.
DNA (Mary Ann Liebert, Inc.) 1987;6(5):401-7.
1987: Tanzi R E; Bird E D; Latt S A; Neve R L
The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease.
Science (New York, N.Y.) 1987;238(4827):666-9.
1987: St George-Hyslop P H; Tanzi R E; Polinsky R J; Neve R L; Pollen D; Drachman D; Growdon J; Cupples L A; Nee L; Myers R H
Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease.
Science (New York, N.Y.) 1987;238(4827):664-6.
1987: Tanzi R E; St George-Hyslop P H; Haines J L; Polinsky R J; Nee L; Foncin J F; Neve R L; McClatchey A I; Conneally P M; Gusella J F
The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene.
Nature 1987;329(6135):156-7.
1987: Gilliam T C; Tanzi R E; Haines J L; Bonner T I; Faryniarz A G; Hobbs W J; MacDonald M E; Cheng S V; Folstein S E; Conneally P M
Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere.
Cell 1987;50(4):565-71.
1987: Watkins P C; Eddy R; Beck A K; Vellucci V; Leverone B; Tanzi R E; Gusella J F; Shows T B
DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11.
DNA (Mary Ann Liebert, Inc.) 1987;6(3):205-12.
1987: Watkins P C; Tanzi R E; Cheng S V; Gusella J F
Molecular genetics of human chromosome 21.
Journal of medical genetics 1987;24(5):257-70.
1987: Wexler N S; Young A B; Tanzi R E; Travers H; Starosta-Rubinstein S; Penney J B; Snodgrass S R; Shoulson I; Gomez F; Ramos Arroyo M A
Homozygotes for Huntington's disease.
Nature 1987;326(6109):194-7.
1987: Tanzi R E; Gusella J F; Watkins P C; Bruns G A; St George-Hyslop P; Van Keuren M L; Patterson D; Pagan S; Kurnit D M; Neve R L
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.
Science (New York, N.Y.) 1987;235(4791):880-4.
1987: Gilliam T C; Healey S T; MacDonald M E; Stewart G D; Wasmuth J J; Tanzi R E; Roy J C; Gusella J F
Isolation of polymorphic DNA fragments from human chromosome 4.
Nucleic acids research 1987;15(4):1445-58.
1987: St George-Hyslop P H; Tanzi R E; Polinsky R J; Haines J L; Nee L; Watkins P C; Myers R H; Feldman R G; Pollen D; Drachman D
The genetic defect causing familial Alzheimer's disease maps on chromosome 21.
Science (New York, N.Y.) 1987;235(4791):885-90.
1987: St George-Hyslop P; Polinsky R; Haines J; Nee L; Tanzi R; Conneally P; Growdon J; Myers R; Pollen D; Drachman D
Search for the familial Alzheimer's disease gene.
Journal of neural transmission. Supplementum 1987;24():13-21.
1986: Youngman S; Sarfarazi M; Quarrell O W; Conneally P M; Gibbons K; Harper P S; Shaw D J; Tanzi R E; Wallace M R; Gusella J F
Studies of a DNA marker (G8) genetically linked to Huntington disease in British families.
Human genetics 1986;73(4):333-9.
1986: Gusella J A; Gilliam T C; MacDonald M E; Cheng S V; Tanzi R E
Molecular genetics of human chromosome 4.
Journal of medical genetics 1986;23(3):193-9.
1986: Breakefield X O; Bressman S B; Kramer P L; Ozelius L; Moskowitz C; Tanzi R; Brin M F; Hobbs W; Kaufman D; Tobin A
Linkage analysis in a family with dominantly inherited torsion dystonia: exclusion of the pro-opiomelanocortin and glutamic acid decarboxylase genes and other chromosomal regions using DNA polymorphisms.
Journal of neurogenetics 1986;3(3):159-75.
1986: Seizinger B R; Tanzi R E; Gilliam T C; Bader J L; Parry D M; Spence M A; Marazita M L; Gibbons K; Hobbs W; Gusella J F
Genetic linkage analysis of neurofibromatosis with DNA markers.
Annals of the New York Academy of Sciences 1986;486():304-10.
1986: Gusella J F; Gilliam T C; Tanzi R E; MacDonald M E; Cheng S V; Wallace M; Haines J; Conneally P M; Wexler N S
Molecular genetics of Huntington's disease.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 1():359-64.
1985: Harper P S; Youngman S; Anderson M A; Sarfarazi M; Quarrell O; Tanzi R; Shaw D; Wallace P; Conneally P M; Gusella J F
Genetic linkage between Huntington's disease and the DNA polymorphism G8 in South Wales families.
Journal of medical genetics 1985;22(6):447-50.
1985: Gusella J F; Tanzi R E; Bader P I; Phelan M C; Stevenson R; Hayden M R; Hofman K J; Faryniarz A G; Gibbons K
Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf-Hirschhorn syndrome.
Nature 1985;318(6041):75-8.
1985: Stewart G D; Tanzi R E; Gusella J F
RFLPS at the D21S19 locus of human chromosome 21.
Nucleic acids research 1985;13(19):7168.
1985: Watkins P C; Tanzi R E; Gibbons K T; Tricoli J V; Landes G; Eddy R; Shows T B; Gusella J F
Isolation of polymorphic DNA segments from human chromosome 21.
Nucleic acids research 1985;13(17):6075-88.
1985: Kittur S D; Antonarakis S E; Tanzi R E; Meyers D A; Chakravarti A; Groner Y; Phillips J A; Watkins P C; Gusella J F; Kazazian H H
A linkage map of three anonymous human DNA fragments and SOD-1 on chromosome 21.
The EMBO journal 1985;4(9):2257-60.
1985: Gusella J F; Tanzi R E; Watkins P C; Gibbons K T; Hobbs W J; Faryniarz A G; Healey S T; Anderson M A
Genetic linkage map for chromosome 21.
Annals of the New York Academy of Sciences 1985;450():25-31.
1984: Gusella J F; Tanzi R E; Anderson M A; Hobbs W; Gibbons K; Raschtchian R; Gilliam T C; Wallace M R; Wexler N S; Conneally P M
DNA markers for nervous system diseases.
Science (New York, N.Y.) 1984;225(4668):1320-6.
1983: Gusella J F; Wexler N S; Conneally P M; Naylor S L; Anderson M A; Tanzi R E; Watkins P C; Ottina K; Wallace M R; Sakaguchi A Y
A polymorphic DNA marker genetically linked to Huntington's disease.
Nature 1983;306(5940):234-8.

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