FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Stephan Targan

Research Profile

Disorders

Chemicals & Drugs

Anatomy

Procedures

Enzyme-Linked Immunosorbent Assay

Physiology

Concepts & Ideas

Co-author Network

Publications

TOP 3
Kathrin S Michelsen; Deepti Dhall; Brian Ko; Lisa S Thomas; Michelle H Wong; Stephan R Targan
HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses.
William J Sandborn; Vera S Byers; Hua Mu; Dean A Rutty; Stephan R Targan; Xun Zhang; Tom Tang
Andrographis paniculata extract (HMPL-004) for active ulcerative colitis.
Robert J Basseri; Dror Berel; Phillip R Fleshner; Bing Hu; Andrew Ippoliti; Juan Lechago; Gil Y Melmed; Stephan R Targan; Eric A Vasiliauskas; Maria E Vassilaki; Benjamin Basseri; Konstantinos A Papadakis
Colorectal cancer screening and surveillance in Crohn's colitis.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Stephan Targan (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Kathrin S Michelsen; Deepti Dhall; Brian Ko; Lisa S Thomas; Michelle H Wong; Stephan R Targan
HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses.
Inflammatory bowel diseases 2013;19(1):151-64.
2013: William J Sandborn; Vera S Byers; Hua Mu; Dean A Rutty; Stephan R Targan; Xun Zhang; Tom Tang
Andrographis paniculata extract (HMPL-004) for active ulcerative colitis.
The American journal of gastroenterology 2013;108(1):90-8.
2012: Robert J Basseri; Dror Berel; Phillip R Fleshner; Bing Hu; Andrew Ippoliti; Juan Lechago; Gil Y Melmed; Stephan R Targan; Eric A Vasiliauskas; Maria E Vassilaki; Benjamin Basseri; Konstantinos A Papadakis
Colorectal cancer screening and surveillance in Crohn's colitis.
Journal of Crohn's & colitis 2012;6(8):824-9.
2012: Travis B Murdoch; Jerome I Rotter; Joanne M Stempak; Stephan R Targan; Wei Xu; Carol Landers; Mark S Silverberg
Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohn's disease.
Inflammatory bowel diseases 2012;18(9):1743-8.
2012: William J Sandborn; Bruce E Sands; Stefan Schreiber; Stephan R Targan; Richard Aranda; Brian Bressler; Jean-Frederic Colombel; Karl Geboes; Sheila Gujrathi; Allison Luo; Remo Panaccione; Yun Peng; Paul Rutgeerts; Luisa Salter-Cid; Stephen B Hanauer
Abatacept for Crohn's disease and ulcerative colitis.
Gastroenterology 2012;143(1):62-69.e4.
2012: Robert Barrett; Dror Berel; Jyh-Yau Chang; Hon Wai Koon ; Kathrin S Michelsen; Mary Ann Nguyen; Charalabos Pothoulakis; Stephan R Targan; Michelle Vu; Nicole Yeager; Xiaolan Zhang; David Q Shih
Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis.
The American journal of pathology 2012;180(2):636-49.
2011: Gary R Lichtenstein; Fred Princen; Jerome I Rotter; Derren M Barken; Michelle Brown; Susan Carroll; Emil Chuang; Marla C Dubinsky; Carol J Landers; Sharat Singh; Jordan Stachelski; Joanne M Stempak; Stephan R Targan; Mark S Silverberg
Combination of genetic and quantitative serological immune markers are associated with complicated Crohn's disease behavior.
Inflammatory bowel diseases 2011;17(12):2488-96.
2011: Hon Wai Koon ; Jeremy Chen; Tressia C Hing; Samantha Ho; David Q Shih; Stephan R Targan; Dezheng Zhao; Charalabos Pothoulakis
Substance P induces CCN1 expression via histone deacetylase activity in human colonic epithelial cells.
The American journal of pathology 2011;179(5):2315-26.
2011: Hon Wai Koon ; Ivy Law; David Q Shih; Stephan R Targan; Hua Xu; Dezheng Zhao; Kyriaki Bakirtzi; Jeremy Chen; Genhong Cheng; Paul Dempsey; Richard Gallo; Tressia C Hing; Samantha Ho; Ryan Ichikawa; Charalabos Pothoulakis
Cathelicidin signaling via the Toll-like receptor protects against colitis in mice.
Gastroenterology 2011;141(5):1852-63.e1-3.
2011: Talin Haritunians; Andrew Ippoliti; Michelle Jones; Lily King; Esther Leshinsky-Silver; Arie Levine; Dermot P B McGovern; Gil Y Melmed; Emebet Mengesha; Jerome I Rotter; David Q Shih; Stephan R Targan; Robert J Barrett; Carrie Derkowski; Marla C Dubinsky; Debra Dutridge; Phillip R Fleshner; Eric A Vasilauskas; Shabnam Ziaee; Kent D Taylor
Variants in ZNF365 isoform D are associated with Crohn's disease.
Gut 2011;60(8):1060-7.
2011: Lola Y Kwan; Stephan R Targan; David Q Shih
A case of steroid-dependent myeloid granulocytic sarcoma masquerading as Crohn's disease.
World journal of gastroenterology : WJG 2011;17(19):2446-9.
2011: Charles Noah Bernstein; Hani El-Gabalawy; Brenda Elias; Carol Landers; Patricia Rawsthorne; Michael Sargent; Stephan R Targan
Assessing inflammatory bowel disease-associated antibodies in Caucasian and First Nations cohorts.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie 2011;25(5):269-73.
2011: Scott Plevy; Stephan R Targan
Future therapeutic approaches for inflammatory bowel diseases.
Gastroenterology 2011;140(6):1838-46.
2011: David Q Shih; Robert Barrett; Xiaolan Zhang; Nicole Yeager; Hon Wai Koon ; Piangwarin Phaosawasdi; Yahui Song; Brian Ko; Michelle H Wong; Kathrin S Michelsen; Gislaine Martins; Charalabos Pothoulakis; Stephan R Targan
Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis.
PloS one 2011;6(1):e16090.
2011: David Q Shih; Kathrin S Michelsen; Robert J Barrett; Eva Biener-Ramanujan; Rivkah Gonsky; Xiaolan Zhang; Stephan R Targan
Insights into TL1A and IBD pathogenesis.
Advances in experimental medicine and biology 2011;691():279-88.
2011: Stephan R Targan
Introductory words about TL1A/DR3.
Advances in experimental medicine and biology 2011;691():271-4.
2011: Rivkah Gonsky; Richard Deem; Carol J Landers; Carrie A Derkowski; Dror Berel; Dermot P B McGovern; Stephan R Targan
Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens.
Inflammatory bowel diseases 2011;17(1):171-8.
2010: William J Sandborn; Jean Frederic Colombel; Matthew Frankel; Daan Hommes; James N Lowder; Lloyd Mayer; Scott Plevy; Pieter Stokkers; Simon Travis; Gert Van Assche; Daniel Baumgart; Stephan R Targan
Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis.
Gut 2010;59(11):1485-92.
2010: Talin Haritunians; Kent D Taylor; Stephan R Targan; Marla C Dubinsky; Andrew Ippoliti; Soonil Kwon; Xiuqing Guo; Gil Y Melmed; Dror Berel; Emebet Mengesha; Bruce M Psaty; Nicole L Glazer; Eric A Vasiliauskas; Jerome I Rotter; Phillip R Fleshner; Dermot P B McGovern
Genetic predictors of medically refractory ulcerative colitis.
Inflammatory bowel diseases 2010;16(11):1830-40.
2010: Dermot P B McGovern; Michelle Jones; Kent D Taylor; Kristin Marciante; Xiaofei Yan; Marla C Dubinsky; Andy Ippoliti; Eric A Vasiliauskas; Dror Berel; Carrie Derkowski; Deb Dutridge; Phil Fleshner; David Q Shih; Gil Y Melmed; Emebet Mengesha; Lily King; Sheila Pressman; Talin Haritunians; Xiuqing Guo; Stephan R Targan; Jerome I Rotter
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
Human molecular genetics 2010;19(17):3468-76.
2010: Andrew Ippoliti; Shane Devlin; Ling Mei; Huiying Yang; Konstantinos A Papadakis; Eric A Vasiliauskas; Dermot P B McGovern; Maria Abreu; Gil Y Melmed; Omid Shaye; Pedram Enayati; Gary Chen; Jennifer Choi; Kent Taylor; Carol J Landers; Jerome I Rotter; Stephan R Targan
Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease.
Inflammatory bowel diseases 2010;16(8):1279-85.
2010: Marla C Dubinsky; Ling Mei; Madison Friedman; Tanvi Dhere; Talin Haritunians; Hakon Hakonarson; Cecilia Kim; Joseph Glessner; Stephan R Targan; Dermot P B McGovern; Kent D Taylor; Jerome I Rotter
Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease.
Inflammatory bowel diseases 2010;16(8):1357-66.
2010: Evan White; Gil Y Melmed; Eric A Vasiliauskas; Marla C Dubinsky; Dror Berel; Stephan R Targan; Phillip R Fleshner
A prospective analysis of clinical variables, serologic factors, and outcome of ileal pouch-anal anastomosis in patients with backwash ileitis.
Diseases of the colon and rectum 2010;53(7):987-94.
2010: Stephanie C Heidemann; Valerie Chavez; Carol J Landers; Torsten Kucharzik; John L Prehn; Stephan R Targan
TL1A selectively enhances IL-12/IL-18-induced NK cell cytotoxicity against NK-resistant tumor targets.
Journal of clinical immunology 2010;30(4):531-8.
2010: Eva Biener-Ramanujan; Rivkah Gonsky; Brian Ko; Stephan R Targan
Functional signaling of membrane-bound TL1A induces IFN-gamma expression.
FEBS letters 2010;584(11):2376-80.
2010: Daniel Baumgart; Stephan R Targan; Axel U Dignass; Lloyd Mayer; Gert van Assche; Daan W Hommes; Stephen B Hanauer; Uma Mahadevan; Walter Reinisch; Scott Plevy; Bruce A Salzberg; Alan L Buchman; Grigor M Mechkov; Zahariy A Krastev; James N Lowder; Matthew B Frankel; William J Sandborn
Prospective randomized open-label multicenter phase I/II dose escalation trial of visilizumab (HuM291) in severe steroid-refractory ulcerative colitis.
Inflammatory bowel diseases 2010;16(4):620-9.
2010: Gil Y Melmed; Stephan R Targan
Future biologic targets for IBD: potentials and pitfalls.
Nature reviews. Gastroenterology & hepatology 2010;7(2):110-7.
2010: David Berman; Susan M Parker; Jonathan Siegel; Scott D Chasalow; Jeffrey Weber; Susan Galbraith; Stephan R Targan; Hanlin L Wang
Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma.
Cancer immunity 2010;10():11.
2010: Gil Y Melmed; Nik Agarwal; Robert W Frenck; Andrew Ippoliti; Patricio Ibanez; Konstantinos A Papadakis; Peter Simpson; Cristina Barolet-Garcia; Joel Ward; Stephan R Targan; Eric A Vasiliauskas
Immunosuppression impairs response to pneumococcal polysaccharide vaccination in patients with inflammatory bowel disease.
The American journal of gastroenterology 2010;105(1):148-54.
2009: David Q Shih; Stephan R Targan
Insights into IBD Pathogenesis.
Current gastroenterology reports 2009;11(6):473-80.
2009: David Q Shih; Lola Y Kwan; Valerie Chavez; Offer Cohavy; Rivkah Gonsky; Elmer Y Chang; Christopher Chang; Charles O Elson; Stephan R Targan
Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells.
European journal of immunology 2009;39(11):3239-50.
2009: Masayuki Saruta; Kathrin S Michelsen; Lisa S Thomas; Qi T Yu; Carol J Landers; Stephan R Targan
TLR8-mediated activation of human monocytes inhibits TL1A expression.
European journal of immunology 2009;39(8):2195-202.
2009: Rivkah Gonsky; Richard Deem; Stephan R Targan
Distinct Methylation of IFNG in the Gut.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2009;29(7):407-14.
2009: Dermot P B McGovern; Jerome I Rotter; Ling Mei; Talin Haritunians; Carol J Landers; Carrie Derkowski; Debra Dutridge; Marla C Dubinsky; Andrew Ippoliti; Eric A Vasiliauskas; Emebet Mengesha; Lily King; Sheila Pressman; Stephan R Targan; Kent D Taylor
Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease.
Inflammatory bowel diseases 2009;15(6):883-9.
2009: Zuri A Murrell; Gil Y Melmed; Andrew Ippoliti; Eric A Vasiliauskas; Marla C Dubinsky; Stephan R Targan; Phillip R Fleshner
A prospective evaluation of the long-term outcome of ileal pouch-anal anastomosis in patients with inflammatory bowel disease-unclassified and indeterminate colitis.
Diseases of the colon and rectum 2009;52(5):872-8.
2009: Daniel Baumgart; James N Lowder; Stephan R Targan; William J Sandborn; Matthew B Frankel
Transient cytokine-induced liver injury following administration of the humanized anti-CD3 antibody visilizumab (HuM291) in Crohn's disease.
The American journal of gastroenterology 2009;104(4):868-76.
2009: Masayuki Saruta; Stephan R Targan; Ling Mei; Andrew F Ippoliti; Kent D Taylor; Jerome I Rotter
High-frequency haplotypes in the X chromosome locus TLR8 are associated with both CD and UC in females.
Inflammatory bowel diseases 2009;15(3):321-7.
2009: Brennan M R Spiegel; Wayne Ho; Eric Esrailian; Stephan R Targan; Peter Higgins; Corey A Siegel; Marla Dubinsky; Gil Y Melmed
Controversies in ulcerative colitis: a survey comparing decision making of experts versus community gastroenterologists.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2009;7(2):168-74, 174.e1.
2009: Kathrin S Michelsen; Lisa S Thomas; Kent D Taylor; Qi T Yu; Ling Mei; Carol J Landers; Carrie Derkowski; Dermot P B McGovern; Jerome I Rotter; Stephan R Targan
IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein.
PloS one 2009;4(3):e4719.
2008: David Q Shih; Stephan R Targan; Dermot McGovern
Recent advances in IBD pathogenesis: genetics and immunobiology.
Current gastroenterology reports 2008;10(6):568-75.
2008: Chong Shen; Carol J Landers; Carrie Derkowski; Charles O Elson; Stephan R Targan
Enhanced CBir1-specific innate and adaptive immune responses in Crohn's disease.
Inflammatory bowel diseases 2008;14(12):1641-51.
2008: Marla C Dubinsky; Subra Kugathasan; Ling Mei; Yoana Picornell; Justin Nebel; Iwona Wrobel; Antonio Quiros; Gary Silber; Ghassan Wahbeh; Lirona Katzir; Eric A Vasiliauskas; Ron Bahar; Anthony Otley; David Mack; Jonathan Evans; Joel Rosh; Maria Oliva-Hemker; Neal Leleiko; Wallace Crandall; Christine Langton; Carol J Landers; Kent D Taylor; Stephan R Targan; Jerome I Rotter; James Markowitz; Jeffrey Hyams
Increased immune reactivity predicts aggressive complicating Crohn's disease in children.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2008;6(10):1105-11.
2008: Sarah Brewer; Michael McPherson; Daisuke Fujiwara; Olga Turovskaya; David Ziring; Ling Chen; Hiroko Takedatsu; Stephan R Targan; Bo Wei; Jonathan Braun
Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography.
Gastroenterology 2008;135(3):744-55.
2008: Kent D Taylor; Stephan R Targan; Ling Mei; Andrew Ippoliti; Dermot McGovern; Emebet Mengesha; Lily King; Jerome I Rotter
IL23R haplotypes provide a large population attributable risk for Crohn's disease.
Inflammatory bowel diseases 2008;14(9):1185-91.
2008: Gil Y Melmed; Stephan R Targan; Uma Yasothan; Delphine Hanicq; Peter Kirkpatrick
Certolizumab pegol.
Nature reviews. Drug discovery 2008;7(8):641-2.
2008: Hidetoshi Takedatsu; Kathrin S Michelsen; Bo Wei; Carol J Landers; Lisa S Thomas; Deepti Dhall; Jonathan Braun; Stephan R Targan
TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.
Gastroenterology 2008;135(2):552-67.
2008: Masato Mitsuhashi; Stephan R Targan
Ex vivo simulation of IgG Fc and T-cell receptor functions: an application to inflammatory bowel disease.
Inflammatory bowel diseases 2008;14(8):1061-7.
2008: Robert A Colbert; Atulya A Deodhar; Muhammad Asim Khan; Rik J Lories; Walter P Maksymowych; John D Reveille; Christopher T Ritchlin; James T Rosenbaum; Stephan R Targan; Michael Weisman; Daniel O Clegg
2007 annual research and education meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN).
The Journal of rheumatology 2008;35(7):1398-402.
2008: Phillip R Fleshner; Andrew Ippoliti; Marla C Dubinsky; Eric A Vasiliauskas; Ling Mei; Konstantinos A Papadakis; Jerome I Rotter; Carol J Landers; Stephan R Targan
Both preoperative perinuclear antineutrophil cytoplasmic antibody and anti-CBir1 expression in ulcerative colitis patients influence pouchitis development after ileal pouch-anal anastomosis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2008;6(5):561-8.
2008: Masato Mitsuhashi; Mieko Ogura; Katsuya Endo; Kazuhiko Obara; Hiroshi Izutsu; Stephan R Targan; Motoko Maemura; Daisuke Tachikawa; Atsushi Shinagawa
Ex vivo induction of mRNA in human whole blood as a new platform of drug and dietary supplement development.
Pharmaceutical research 2008;25(5):1116-24.
2008: Peggy Vandewalle-El Khoury; Jean-Frédéric Colombel; Sofie Joossens; Annie Standaert-Vitse; Mayeul Collot; Jonas Halfvarson; Ali Ayadi; Carol J Landers; Severine Vermeire; Paul Rutgeerts; Stephan R Targan; Mathias Chamaillard; Jean-Maurice Mallet; Boualem Sendid; Daniel Poulain
Detection of antisynthetic mannoside antibodies (ASigmaMA) reveals heterogeneity in the ASCA response of Crohn's disease patients and contributes to differential diagnosis, stratification, and prediction.
The American journal of gastroenterology 2008;103(4):949-57.
2008: David Q Shih; Stephan R Targan
Immunopathogenesis of inflammatory bowel disease.
World journal of gastroenterology : WJG 2008;14(3):390-400.
2008: Gil Y Melmed; Phillip R Fleshner; Ovunc Bardakcioglu; Andrew Ippoliti; Eric A Vasiliauskas; Konstantinos A Papadakis; Marla C Dubinsky; Carol J Landers; Jerome I Rotter; Stephan R Targan
Family history and serology predict Crohn's disease after ileal pouch-anal anastomosis for ulcerative colitis.
Diseases of the colon and rectum 2008;51(1):100-8.
2007: Scott Plevy; Bruce Salzberg; Gert Van Assche; Miguel Regueiro; Daniel Hommes; William Sandborn; Stephen B Hanauer; Stephan R Targan; Lloyd Mayer; Uma Mahadevan; Matthew Frankel; James Lowder
A phase I study of visilizumab, a humanized anti-CD3 monoclonal antibody, in severe steroid-refractory ulcerative colitis.
Gastroenterology 2007;133(5):1414-22.
2007: Stefanie J Schluender; Andrew Ippoliti; Marla C Dubinsky; Eric A Vasiliauskas; Konstantinos A Papadakis; Ling Mei; Stephan R Targan; Phillip R Fleshner
Does infliximab influence surgical morbidity of ileal pouch-anal anastomosis in patients with ulcerative colitis?
Diseases of the colon and rectum 2007;50(11):1747-53.
2007: Yoana Picornell; Ling Mei; Kent Taylor; Huiying Yang; Stephan R Targan; Jerome I Rotter
TNFSF15 is an ethnic-specific IBD gene.
Inflammatory bowel diseases 2007;13(11):1333-8.
2007: Eric Esrailian; Brennan M R Spiegel; Laura E Targownik; M C Dubinsky; Stephan R Targan; Ian M Gralnek
Differences in the management of Crohn's disease among experts and community providers, based on a national survey of sample case vignettes.
Alimentary pharmacology & therapeutics 2007;26(7):1005-18.
2007: Phillip R Fleshner; Andrew Ippoliti; Marla C Dubinsky; Steven Ognibene; Eric A Vasiliauskas; Marjorie R Chelly; Ling Mei; Konstantinos A Papadakis; Carol J Landers; Stephan R Targan
A prospective multivariate analysis of clinical factors associated with pouchitis after ileal pouch-anal anastomosis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2007;5(8):952-8; quiz 887.
2007: Michael Clark; Jean-Frédéric Colombel; Brian C Feagan; Richard N Fedorak; Stephen B Hanauer; Michael A Kamm; Lloyd Mayer; Carol Regueiro; Paul Rutgeerts; William J Sandborn; Bruce Sands; Stefan Schreiber; Stephan R Targan; Simon Travis; Severine Vermeire
American gastroenterological association consensus development conference on the use of biologics in the treatment of inflammatory bowel disease, June 21-23, 2006.
Gastroenterology 2007;133(1):312-39.
2007: Stephan R Targan; Loren C Karp
Inflammatory bowel disease diagnosis, evaluation and classification: state-of-the art approach.
Current opinion in gastroenterology 2007;23(4):390-4.
2007: Stephan R Targan; Brian G Feagan; Richard N Fedorak; Bret A Lashner; Remo Panaccione; Daniel H Present; Martina E Spehlmann; Paul J Rutgeerts; Zsolt Tulassay; Miroslava Volfova; Douglas C Wolf; Chito Hernandez; Jeffrey Bornstein; William J Sandborn
Natalizumab for the treatment of active Crohn's disease: results of the ENCORE Trial.
Gastroenterology 2007;132(5):1672-83.
2007: Gil Y Melmed; Robert Elashoff; Gary C Chen; Igor Nastaskin; Konstantinos A Papadakis; Eric A Vasiliauskas; Weiqing Liu; Carol J Landers; Andrew Ippoliti; Stephan R Targan
Predicting a change in diagnosis from ulcerative colitis to Crohn's disease: a nested, case-control study.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2007;5(5):602-8; quiz 525.
2007: Offer Cohavy; Stephan R Targan
CD56 marks an effector T cell subset in the human intestine.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5524-32.
2007: John D Rioux; Ramnik Xavier; Kent D Taylor; Mark S Silverberg; Philippe Goyette; Alan Huett; Todd Green; Petric Kuballa; M. Michael Barmada; Lisa Datta; Yin Yao Shugart; Anne M Griffiths; Stephan R Targan; Andrew Ippoliti; Edmond-Jean Bernard; Ling Mei; Dan L Nicolae; Miguel Regueiro; L Philip Schumm; A Hillary Steinhart; Jerome I Rotter; Richard H Duerr; Judy H Cho; Mark J Daly; Steven R Brant
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
Nature genetics 2007;39(5):596-604.
2007: Marla C Dubinsky; Dai Wang; Yoana Picornell; Iwona Wrobel; Lirona Katzir; Antonio Quiros; Debra Dutridge; Ghassan Wahbeh; Gary Silber; Ron Bahar; Emebet Mengesha; Stephan R Targan; Kent D Taylor; Jerome I Rotter
IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease.
Inflammatory bowel diseases 2007;13(5):511-5.
2007: Konstantinos A Papadakis; Huiying Yang; Andrew Ippoliti; Ling Mei; Charles O Elson; Robert M Hershberg; Eric A Vasiliauskas; Phillip R Fleshner; Maria Abreu; Kent Taylor; Carol J Landers; Jerome I Rotter; Stephan R Targan
Anti-flagellin (CBir1) phenotypic and genetic Crohn's disease associations.
Inflammatory bowel diseases 2007;13(5):524-30.
2007: John L Prehn; Lisa S Thomas; Carol J Landers; Qi T Yu; Kathrin S Michelsen; Stephan R Targan
The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4033-8.
2007: Masayuki Saruta; Qi T Yu; Armine Avanesyan; Phillip R Fleshner; Stephan R Targan; Konstantinos A Papadakis
Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):3293-300.
2007: Shane M Devlin; Huiying Yang; Andrew Ippoliti; Kent D Taylor; Carol J Landers; Xiaowen Su; Maria Abreu; Konstantinos A Papadakis; Eric A Vasiliauskas; Gil Y Melmed; Phillip R Fleshner; Ling Mei; Jerome I Rotter; Stephan R Targan
NOD2 variants and antibody response to microbial antigens in Crohn's disease patients and their unaffected relatives.
Gastroenterology 2007;132(2):576-86.
2006: Jacob Spivak; Carol J Landers; Eric A Vasiliauskas; Maria Abreu; Marla C Dubinsky; Konstantinos A Papadakis; Andrew Ippoliti; Stephan R Targan; Phillip R Fleshner
Antibodies to I2 predict clinical response to fecal diversion in Crohn's disease.
Inflammatory bowel diseases 2006;12(12):1122-30.
2006: Richard H Duerr; Kent D Taylor; Steven R Brant; John D Rioux; Mark S Silverberg; Mark J Daly; A Hillary Steinhart; Clara Abraham; Miguel Regueiro; Anne Griffiths; Themistocles Dassopoulos; Alain Bitton; Huiying Yang; Stephan R Targan; Lisa Datta; Emily O Kistner; L Philip Schumm; Annette T Lee; Peter K Gregersen; M. Michael Barmada; Jerome I Rotter; Dan L Nicolae; Judy H Cho
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
Science (New York, N.Y.) 2006;314(5804):1461-3.
2006: Torsten Kucharzik; Christian Maaser; Andreas Lügering; Martin F Kagnoff; Lloyd Mayer; Stephan R Targan; Wolfram Domschke
Recent understanding of IBD pathogenesis: implications for future therapies.
Inflammatory bowel diseases 2006;12(11):1068-83.
2006: Eric A Vasiliauskas; Joseph A Church; Neil Silverman; Mary Barry; Stephan R Targan; Marla C Dubinsky
Case report: evidence for transplacental transfer of maternally administered infliximab to the newborn.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2006;4(10):1255-8.
2006: Charles O Elson; Yingzi Cong; Fengxia Qi; Robert M Hershberg; Stephan R Targan
Molecular approaches to the role of the microbiota in inflammatory bowel disease.
Annals of the New York Academy of Sciences 2006;1072():39-51.
2006: Stephan R Targan
Current limitations of IBD treatment: where do we go from here?
Annals of the New York Academy of Sciences 2006;1072():1-8.
2006: Gil Y Melmed; Andrew Ippoliti; Konstantinos A Papadakis; Tram T Tran; Jaime L Birt; Susie K Lee; Robert W Frenck; Stephan R Targan; Eric A Vasiliauskas
Patients with inflammatory bowel disease are at risk for vaccine-preventable illnesses.
The American journal of gastroenterology 2006;101(8):1834-40.
2006: Rivkah Gonsky; Richard Deem; Jay H Bream; Howard A Young; Stephan R Targan
An IFNG SNP with an estrogen-like response element selectively enhances promoter expression in peripheral but not lamina propria T cells.
Genes and immunity 2006;7(5):342-51.
2006: Marla C Dubinsky; Kent Taylor; Stephan R Targan; Jerome I Rotter
Immunogenetic phenotypes in inflammatory bowel disease.
World journal of gastroenterology : WJG 2006;12(23):3645-50.
2006: Ling Mei; Stephan R Targan; Carol J Landers; Debra Dutridge; Andrew Ippoliti; Eric A Vasiliauskas; Konstantinos A Papadakis; Phillip R Fleshner; Jerome I Rotter; Huiying Yang
Familial expression of anti-Escherichia coli outer membrane porin C in relatives of patients with Crohn's disease.
Gastroenterology 2006;130(4):1078-85.
2006: Marla C Dubinsky; Ying-Chao Lin; Debra Dutridge; Yoana Picornell; Carol J Landers; Sharmayne Farrior; Iwona Wrobel; Antonio Quiros; Eric A Vasiliauskas; Bruce Grill; David Israel; Ron Bahar; Dennis Christie; Ghassan Wahbeh; Gary Silber; Saied Dallazadeh; Praful Shah; Danny Thomas; Drew Kelts; Robert M Hershberg; Charles O Elson; Stephan R Targan; Kent D Taylor; Jerome I Rotter; Huiying Yang
Serum immune responses predict rapid disease progression among children with Crohn's disease: immune responses predict disease progression.
The American journal of gastroenterology 2006;101(2):360-7.
2006: Jonathan Braun; Stephan R Targan
Multiparameter analysis of immunogenetic mechanisms in clinical diagnosis and management of inflammatory bowel disease.
Advances in experimental medicine and biology 2006;579():209-18.
2006: Maria Abreu; Jordan L Geller; Eric A Vasiliauskas; Lori Y Kam; Puja Vora; Lenna A Martyak; Huiying Yang; Bei Hu; Ying-Chao Lin; Gregory Keenan; Joanne Price; Carol J Landers; John S Adams; Stephan R Targan
Treatment with infliximab is associated with increased markers of bone formation in patients with Crohn's disease.
Journal of clinical gastroenterology 2006;40(1):55-63.
2005: William J Sandborn; Jean-Frédéric Colombel; Roberts Enns; Brian G Feagan; Stephen B Hanauer; Ian Craig Lawrance; Remo Panaccione; Martin Sanders; Stefan Schreiber; Stephan R Targan; Sander J H van Deventer; Ronald Goldblum; Darrin Despain; Gary S Hogge; Paul Rutgeerts
Natalizumab induction and maintenance therapy for Crohn's disease.
The New England journal of medicine 2005;353(18):1912-25.
2005: Kim L Isaacs; James D Lewis; William J Sandborn; Bruce Sands; Stephan R Targan
State of the art: IBD therapy and clinical trials in IBD.
Inflammatory bowel diseases 2005;11 Suppl 1():S3-12.
2005: Aderet Okon; Marla C Dubinsky; Eric A Vasiliauskas; Konstantinos A Papadakis; Andrew Ippoliti; Stephan R Targan; Phillip R Fleshner
Elevated platelet count before ileal pouch-anal anastomosis for ulcerative colitis is associated with the development of chronic pouchitis.
The American surgeon 2005;71(10):821-6.
2005: Mark S Silverberg; Jack Satsangi; Tariq Ahmad; I D R Arnott; Charles N Bernstein; Steven R Brant; Renzo Caprilli; Jean-Frédéric Colombel; Christoph Gasche; Karel Geboes; Derek P Jewell; Amir Karban; Edward V Loftus Jr; Amado Salvador Peña; Robert H Riddell; David B Sachar; Stefan Schreiber; A Hillary Steinhart; Stephan R Targan; Severine Vermeire; B F Warren
Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie 2005;19 Suppl A():5-36.
2005: Stephan R Targan; Loren C Karp
Defects in mucosal immunity leading to ulcerative colitis.
Immunological reviews 2005;206():296-305.
2005: Stephan R Targan; Carol J Landers; Huiying Yang; Michael J Lodes; Yingzi Cong; Konstantinos A Papadakis; Eric A Vasiliauskas; Charles O Elson; Robert M Hershberg
Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease.
Gastroenterology 2005;128(7):2020-8.
2005: Thomas Hui; Carol J Landers; Eric A Vasiliauskas; Maria Abreu; Marla C Dubinsky; Konstantinos A Papadakis; Joanne Price; Ying-Chao Lin; Yang Huiying; Stephan R Targan; Phillip R Fleshner
Serologic responses in indeterminate colitis patients before ileal pouch-anal anastomosis may determine those at risk for continuous pouch inflammation.
Diseases of the colon and rectum 2005;48(6):1254-62.
2005: Konstantinos A Papadakis; Daocheng Zhu; John L Prehn; Carol J Landers; Armine Avanesyan; Gina Lafkas; Stephan R Targan
Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4985-90.
2005: Shanthi V Sitaraman; Jan-Michael Klapproth; Daniel A Moore; Carol J Landers; Stephan R Targan; Ifor Williams; Andrew T Gewirtz
Elevated flagellin-specific immunoglobulins in Crohn's disease.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(2):G403-6.
2005: Offer Cohavy; Jaclyn Zhou; Carl Ware; Stephan R Targan
LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(2):646-53.
2005: Konstantinos A Papadakis; Omid A Shaye; Eric A Vasiliauskas; Andrew Ippoliti; Marla C Dubinsky; Jaime Birt; Jane Paavola; Susie K Lee; Joanne Price; Stephan R Targan; Maria Abreu
Safety and efficacy of adalimumab (D2E7) in Crohn's disease patients with an attenuated response to infliximab.
The American journal of gastroenterology 2005;100(1):75-9.
2004: I D R Arnott; Carol J Landers; Elaine J Nimmo; Hazel E Drummond; Ben K R Smith; Stephan R Targan; Jack Satsangi
Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype.
The American journal of gastroenterology 2004;99(12):2376-84.
2004: Rivkah Gonsky; Richard Deem; Jay H Bream; Howard A Young; Stephan R Targan
Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6241-7.
2004: Konstantinos A Papadakis; John L Prehn; Daocheng Zhu; Carol J Landers; Joanne Gaiennie; Phillip R Fleshner; Stephan R Targan
Expression and regulation of the chemokine receptor CXCR3 on lymphocytes from normal and inflammatory bowel disease mucosa.
Inflammatory bowel diseases 2004;10(6):778-88.
2004: Jay H Bream; Deborah L Hodge; Rivkah Gonsky; Rosanne Spolski; Warren J Leonard; Stephanie Krebs; Stephan R Targan; Akio Morinobu; John O'Shea; Howard A Young
A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2.
The Journal of biological chemistry 2004;279(39):41249-57.
2004: Stephen A Geller; Marla C Dubinsky; F Fred Poordad; Eric A Vasiliauskas; Arthur H Cohen; Maria Abreu; Tram Tran; Paul Martin; John M Vierling; Stephan R Targan
Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel disease.
The American journal of surgical pathology 2004;28(9):1204-11.
2004: K A Papadakis; Robin Matuk; Maria Abreu; Eric A Vasiliauskas; Phillip R Fleshner; Juan Lechago; T Tran; F Fred Poordad; Paul Martin; John M Vierling; Stephan R Targan
Crohn's ileitis after liver transplantation from a living related donor with Crohn's disease.
Gut 2004;53(9):1389-90.
2004: William S Mow; Carol J Landers; A Hillary Steinhart; Brian G Feagan; Ken Croitoru; Ernest Seidman; Gordon R Greenberg; Stephan R Targan
High-level serum antibodies to bacterial antigens are associated with antibiotic-induced clinical remission in Crohn's disease: a pilot study.
Digestive diseases and sciences 2004;49(7-8):1280-6.
2004: Robin Matuk; Jonathan Crawford; Maria Abreu; Stephan R Targan; Eric A Vasiliauskas; Konstantinos A Papadakis
The spectrum of gastrointestinal toxicity and effect on disease activity of selective cyclooxygenase-2 inhibitors in patients with inflammatory bowel disease.
Inflammatory bowel diseases 2004;10(4):352-6.
2004: Adrienne Youdim; Eric A Vasiliauskas; Stephan R Targan; Konstantinos A Papadakis; Andrew Ippoliti; Marla C Dubinsky; Juan Lechago; Jane Paavola; Jaime Loane; Susie K Lee; Joanne Gaiennie; Katie Smith; Jason Do; Maria Abreu
A pilot study of adalimumab in infliximab-allergic patients.
Inflammatory bowel diseases 2004;10(4):333-8.
2004: Offer Cohavy; Jaclyn Zhou; Steven Granger; Carl Ware; Stephan R Targan
LIGHT expression by mucosal T cells may regulate IFN-gamma expression in the intestine.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):251-8.
2004: John L Prehn; shahab mehdizadeh; Carol J Landers; Xia Luo; Stephanie C Cha; Ping Wei; Stephan R Targan
Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation.
Clinical immunology (Orlando, Fla.) 2004;112(1):66-77.
2004: Konstantinos A Papadakis; John L Prehn; Carol J Landers; Qiwei Han; Xia Luo; Stephanie C Cha; Ping Wei; Stephan R Targan
TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):7002-7.
2004: Michael J Lodes; Yingzi Cong; Charles O Elson; Raodoh Mohamath; Carol J Landers; Stephan R Targan; Madeline Fort; Robert M Hershberg
Bacterial flagellin is a dominant antigen in Crohn disease.
The Journal of clinical investigation 2004;113(9):1296-306.
2004: William S Mow; Maria T Abreu-Martin; Konstantinos A Papadakis; Howard E Pitchon; Stephan R Targan; Eric A Vasiliauskas
High incidence of anergy in inflammatory bowel disease patients limits the usefulness of PPD screening before infliximab therapy.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2004;2(4):309-13.
2004: William S Mow; Eric A Vasiliauskas; Ying-Chao Lin; Phillip R Fleshner; Konstantinos A Papadakis; Kent D Taylor; Carol J Landers; Maria T Abreu-Martin; Jerome I Rotter; Huiying Yang; Stephan R Targan
Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease.
Gastroenterology 2004;126(2):414-24.
2004: William S Mow; Simon K Lo; Stephan R Targan; Marla C Dubinsky; Leo Treyzon; Maria T Abreu-Martin; Konstantinos A Papadakis; Eric A Vasiliauskas
Initial experience with wireless capsule enteroscopy in the diagnosis and management of inflammatory bowel disease.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2004;2(1):31-40.
2003: Konstantinos A Papadakis; Leo Treyzon; Maria Abreu; Phillip R Fleshner; Stephan R Targan; Eric A Vasiliauskas
Infliximab in the treatment of medically refractory indeterminate colitis.
Alimentary pharmacology & therapeutics 2003;18(7):741-7.
2003: Marla C Dubinsky; Eric A Vasiliauskas; Hardeep Singh; Maria Abreu; Konstantinos A Papadakis; Tram Tran; Paul Martin; John M Vierling; Stephen A Geller; Stephan R Targan; F Fred Poordad
6-thioguanine can cause serious liver injury in inflammatory bowel disease patients.
Gastroenterology 2003;125(2):298-303.
2003: Konstantinos A Papadakis; Carol J Landers; John L Prehn; Elias A Kouroumalis; Sofia T Moreno; Jose-Carlos Gutierrez-Ramos; Martin R Hodge; Stephan R Targan
CC chemokine receptor 9 expression defines a subset of peripheral blood lymphocytes with mucosal T cell phenotype and Th1 or T-regulatory 1 cytokine profile.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):159-65.
2003: Marla C Dubinsky; Edward J Feldman; Maria Abreu; Stephan R Targan; Eric A Vasiliauskas
Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine.
The American journal of gastroenterology 2003;98(5):1058-63.
2003: Charles O Elson; Ryan Sartor; Stephan R Targan; William J Sandborn
Challenges in IBD Research: updating the scientific agendas.
Inflammatory bowel diseases 2003;9(3):137-53.
2003: Rivkah Gonsky; Richard Deem; Howard A Young; Stephan R Targan
CD2 mediates activation of the IFN-gamma intronic STAT binding region in mucosal T cells.
European journal of immunology 2003;33(5):1152-62.
2003: Kazuhito Sugimura; Kent D Taylor; Ying-chao Lin; Tieu Hang; Dai Wang; Yong-Ming Tang; Nathan Fischel-Ghodsian; Stephan R Targan; Jerome I Rotter; Huiying Yang
A novel NOD2/CARD15 haplotype conferring risk for Crohn disease in Ashkenazi Jews.
American journal of human genetics 2003;72(3):509-18.
2003: Konstantinos A Papadakis; Barry Rosenbloom; Stephan R Targan
Anti-CD2O chimeric monoclonal antibody (rituximab) treatment of immune-mediated thrombocytopenia associated with Crohn's disease.
Gastroenterology 2003;124(2):583.
2002: Carol J Landers; Offer Cohavy; Rajeev Misra; Huiying Yang; Ying-Chao Lin; Jonathan Braun; Stephan R Targan
Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens.
Gastroenterology 2002;123(3):689-99.
2002: Maria Abreu; Kent D Taylor; Ying-Chao Lin; Tieu Hang; Joanne Gaiennie; Carol J Landers; Eric A Vasiliauskas; Lori Y Kam; Micha Rojany; Konstantinos A Papadakis; Jerome I Rotter; Stephan R Targan; Huiying Yang
Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease.
Gastroenterology 2002;123(3):679-88.
2002: William J Sandborn; Stephan R Targan
Biologic therapy of inflammatory bowel disease.
Gastroenterology 2002;122(6):1592-608.
2002: Marla C Dubinsky; Huiying Yang; Phillip Hassard; Ernest G Seidman; Lori Y Kam; Maria Abreu; Stephan R Targan; Eric A Vasiliauskas
6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.
Gastroenterology 2002;122(4):904-15.
2001: Phillip R Fleshner; Eric A Vasiliauskas; Lori Y Kam; N E Fleshner; Joanne Gaiennie; Maria T Abreu-Martin; Stephan R Targan
High level perinuclear antineutrophil cytoplasmic antibody (pANCA) in ulcerative colitis patients before colectomy predicts the development of chronic pouchitis after ileal pouch-anal anastomosis.
Gut 2001;49(5):671-7.
2001: Bo Wei; Harnisha Dalwadi; Lynn K Gordon; Carol J Landers; David A Bruckner; Stephan R Targan; Jonathan Braun
Molecular cloning of a Bacteroides caccae TonB-linked outer membrane protein identified by an inflammatory bowel disease marker antibody.
Infection and immunity 2001;69(10):6044-54.
2001: John L Prehn; Carol J Landers; George W Muller; Hon-Wah Man; David I Stirling; Stephan R Targan
Potent inhibition of cytokine production from intestinal lamina propria T cells by phosphodiesterase-4 inhibitory thalidomide analogues.
Journal of clinical immunology 2001;21(5):357-64.
2001: Marla C Dubinsky; Phillip Hassard; Ernest G Seidman; Lori Y Kam; Maria Abreu; Stephan R Targan; Eric A Vasiliauskas
An open-label pilot study using thioguanine as a therapeutic alternative in Crohn's disease patients resistant to 6-mercaptopurine therapy.
Inflammatory bowel diseases 2001;7(3):181-9.
2001: Konstantinos A Papadakis; John L Prehn; S T Moreno; L Cheng; E A Kouroumalis; R Deem; T Breaverman; Paul D Ponath; David Andrew; P H Green; Martin R Hodge; SW Binder; Stephan R Targan
CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease.
Gastroenterology 2001;121(2):246-54.
2001: Konstantinos A Papadakis; J K Tung; SW Binder; Lori Y Kam; Maria Abreu; Stephan R Targan; Eric A Vasiliauskas
Outcome of cytomegalovirus infections in patients with inflammatory bowel disease.
The American journal of gastroenterology 2001;96(7):2137-42.
2001: Kent D Taylor; Scott Plevy; Huiying Yang; Carol J Landers; M J Barry; Jerome I Rotter; Stephan R Targan
ANCA pattern and LTA haplotype relationship to clinical responses to anti-TNF antibody treatment in Crohn's disease.
Gastroenterology 2001;120(6):1347-55.
2001: Freddy Cornillie; D Shealy; Geert D'Haens; Karel Geboes; Gert van Assche; J Ceuppens; C Wagner; TF Schaible; Scott Plevy; Stephan R Targan; Paul Rutgeerts
Infliximab induces potent anti-inflammatory and local immunomodulatory activity but no systemic immune suppression in patients with Crohn's disease.
Alimentary pharmacology & therapeutics 2001;15(4):463-73.
2001: Marla C Dubinsky; Joshua J Ofman; M Urman; Stephan R Targan; Ernest G Seidman
Clinical utility of serodiagnostic testing in suspected pediatric inflammatory bowel disease.
The American journal of gastroenterology 2001;96(3):758-65.
2000: Mark Pimentel; M Chang; Evelyn J Chow; S Tabibzadeh; V Kirit-Kiriak; Stephan R Targan; Henry C Lin
Identification of a prodromal period in Crohn's disease but not ulcerative colitis.
The American journal of gastroenterology 2000;95(12):3458-62.
2000: Konstantinos A Papadakis; John L Prehn; V Nelson; L Cheng; SW Binder; Paul D Ponath; David Andrew; Stephan R Targan
The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5069-76.
2000: Eric A Vasiliauskas; Lori Y Kam; Loren C Karp; Joanne Gaiennie; Huiying Yang; Stephan R Targan
Marker antibody expression stratifies Crohn's disease into immunologically homogeneous subgroups with distinct clinical characteristics.
Gut 2000;47(4):487-96.
2000: Stephan R Targan
Biology of inflammation in Crohn's disease: mechanisms of action of anti-TNF-a therapy.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie 2000;14 Suppl C():13C-16C.
2000: F A Rowe; J H Walker; Loren C Karp; Eric A Vasiliauskas; Scott Plevy; Stephan R Targan
Factors predictive of response to cyclosporin treatment for severe, steroid-resistant ulcerative colitis.
The American journal of gastroenterology 2000;95(8):2000-8.
2000: Christopher L Sutton; J Kim; A Yamane; Harnisha Dalwadi; Bo Wei; Carol J Landers; Stephan R Targan; Jonathan Braun
Identification of a novel bacterial sequence associated with Crohn's disease.
Gastroenterology 2000;119(1):23-31.
2000: Lori Y Kam; Stephan R Targan
TNF-alpha antagonists for the treatment of Crohn's disease.
Expert opinion on pharmacotherapy 2000;1(4):615-22.
2000: Marla C Dubinsky; S Lamothe; H Y Yang; Stephan R Targan; Daniel Sinnett; Yves Théorêt; Ernest G Seidman
Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease.
Gastroenterology 2000;118(4):705-13.
2000: Offer Cohavy; David A Bruckner; Lynn K Gordon; R Misra; Bo Wei; ME Eggena; Stephan R Targan; Jonathan Braun
Colonic bacteria express an ulcerative colitis pANCA-related protein epitope.
Infection and immunity 2000;68(3):1542-8.
2000: Phillip Hassard; Eric A Vasiliauskas; Lori Y Kam; Stephan R Targan; Maria Abreu
Efficacy of mycophenolate mofetil in patients failing 6-mercaptopurine or azathioprine therapy for Crohn's disease.
Inflammatory bowel diseases 2000;6(1):16-20.
2000: ME Eggena; Offer Cohavy; MH Parseghian; BA Hamkalo; Daniel L Clemens; Stephan R Targan; Lynn K Gordon; Jonathan Braun
Identification of histone H1 as a cognate antigen of the ulcerative colitis-associated marker antibody pANCA.
Journal of autoimmunity 2000;14(1):83-97.
2000: Rivkah Gonsky; Richard Deem; Jay H Bream; D H Lee; Howard A Young; Stephan R Targan
Mucosa-specific targets for regulation of IFN-gamma expression: lamina propria T cells use different cis-elements than peripheral blood T cells to regulate transactivation of IFN-gamma expression.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1399-407.
2000: Lynn K Gordon; ME Eggena; Stephan R Targan; Jonathan Braun
Mast cell and neuroendocrine cytoplasmic autoantigen(s) detected by monoclonal pANCA antibodies.
Clinical immunology (Orlando, Fla.) 2000;94(1):42-50.
2000: Christopher L Sutton; Huiying Yang; Z Li; Jerome I Rotter; Stephan R Targan; Jonathan Braun
Familial expression of anti-Saccharomyces cerevisiae mannan antibodies in affected and unaffected relatives of patients with Crohn's disease.
Gut 2000;46(1):58-63.
1999: Konstantinos A Papadakis; Stephan R Targan
Serologic testing in inflammatory bowel disease: its value in indeterminate colitis.
Current gastroenterology reports 1999;1(6):482-5.
1999: Eric A Vasiliauskas; Lori Y Kam; Maria T Abreu-Martin; Phillip Hassard; Konstantinos A Papadakis; Huiying Yang; J B Zeldis; Stephan R Targan
An open-label pilot study of low-dose thalidomide in chronically active, steroid-dependent Crohn's disease.
Gastroenterology 1999;117(6):1278-87.
1999: Offer Cohavy; G Harth; M Horwitz; ME Eggena; Carol J Landers; C Sutton; Stephan R Targan; Jonathan Braun
Identification of a novel mycobacterial histone H1 homologue (HupB) as an antigenic target of pANCA monoclonal antibody and serum immunoglobulin A from patients with Crohn's disease.
Infection and immunity 1999;67(12):6510-7.
1999: John L Prehn; Carol J Landers; Stephan R Targan
A soluble factor produced by lamina propria mononuclear cells is required for TNF-alpha enhancement of IFN-gamma production by T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4277-83.
1999: Paul Rutgeerts; Geert D'Haens; Stephan R Targan; Eric A Vasiliauskas; S B Hanauer; Daniel H Present; L Mayer; R A Van Hogezand; T Braakman; KL DeWoody; TF Schaible; Sander J H van Deventer
Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease.
Gastroenterology 1999;117(4):761-9.
1999: William J Sandborn; William J Tremaine; D C Wolf; Stephan R Targan; C A Sninsky; L R Sutherland; Stephen B Hanauer; J W McDonald; Brian G Feagan; Richard N Fedorak; Kim L Isaacs; MG Pike; Dennis C Mays; James J Lipsky; S Gordon; CS Kleoudis; RH Murdock
Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease. North American Azathioprine Study Group.
Gastroenterology 1999;117(3):527-35.
1999: Konstantinos A Papadakis; Stephan R Targan
Current theories on the causes of inflammatory bowel disease.
Gastroenterology clinics of North America 1999;28(2):283-96.
1999: Rivkah Gonsky; Richard Deem; D H Lee; A Chen; Stephan R Targan
CD28 costimulation augments IL-2 secretion of activated lamina propria T cells by increasing mRNA stability without enhancing IL-2 gene transactivation.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6621-9.
1999: Daniel H Present; Paul Rutgeerts; Stephan R Targan; S B Hanauer; L Mayer; Ruud A van Hogezand; D K Podolsky; Bruce Sands; T Braakman; KL DeWoody; TF Schaible; Sander J H van Deventer
Infliximab for the treatment of fistulas in patients with Crohn's disease.
The New England journal of medicine 1999;340(18):1398-405.
1999: Katherine Facklis; Scott Plevy; Eric A Vasiliauskas; Lori Y Kam; K Taylor; Stephan R Targan; Phillip R Fleshner
Crohn's disease-associated genetic marker is seen in medically unresponsive ulcerative colitis patients and may be associated with pouch-specific complications.
Diseases of the colon and rectum 1999;42(5):601-5; discussion 605-6.
1999: Lynn K Gordon; ME Eggena; Stephan R Targan; Jonathan Braun
Definition of ocular antigens in ciliary body and retinal ganglion cells by the marker antibody pANCA.
Investigative ophthalmology & visual science 1999;40(6):1250-5.
1999: Huiying Yang; Scott Plevy; K Taylor; Dolly Tyan; Nathan Fischel-Ghodsian; C McElree; Stephan R Targan; Jerome I Rotter
Linkage of Crohn's disease to the major histocompatibility complex region is detected by multiple non-parametric analyses.
Gut 1999;44(4):519-26.
1999: Maria T Abreu-Martin; AA Palladino; M Faris; N M Carramanzana; Andre E Nel; Stephan R Targan
Fas activates the JNK pathway in human colonic epithelial cells: lack of a direct role in apoptosis.
The American journal of physiology 1999;276(3 Pt 1):G599-605.
1998: Frank M Ruemmele; Stephan R Targan; G Levy; Marla C Dubinsky; J Braun; Ernest G Seidman
Diagnostic accuracy of serological assays in pediatric inflammatory bowel disease.
Gastroenterology 1998;115(4):822-9.
1998: Rivkah Gonsky; Richard Deem; C C Hughes; Stephan R Targan
Activation of the CD2 pathway in lamina propria T cells up-regulates functionally active AP-1 binding to the IL-2 promoter, resulting in messenger RNA transcription and IL-2 secretion.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4914-22.
1998: A G Kaditis; Jean Perrault; William J Sandborn; C J Landers; Alan R Zinsmeister; Stephan R Targan
Antineutrophil cytoplasmic antibody subtypes in children and adolescents after ileal pouch-anal anastomosis for ulcerative colitis.
Journal of pediatric gastroenterology and nutrition 1998;26(4):386-92.
1997: Scott Plevy; Carol J Landers; John L Prehn; N M Carramanzana; Richard Deem; D Shealy; Stephan R Targan
A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):6276-82.
1997: Stephan R Targan; S B Hanauer; Sander J H van Deventer; L Mayer; Daniel H Present; T Braakman; KL DeWoody; TF Schaible; Paul Rutgeerts
A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group.
The New England journal of medicine 1997;337(15):1029-35.
1997: RF Compton; William J Sandborn; Huiying Yang; Noralane M Lindor; William J Tremaine; M D Davis; A A Khalil; Nikolaos A Tountas; Dolly Tyan; Carol J Landers; Kent D Taylor; T R Viggiano; E L Matteson; A L Schroeter; Scott Plevy; Fabio Cominelli; Stephan R Targan; Jerome I Rotter
A new syndrome of Crohn's disease and pachydermoperiostosis in a family.
Gastroenterology 1997;112(1):241-9.
1996: Eric A Vasiliauskas; Scott Plevy; Carol J Landers; S W Binder; D M Ferguson; Huiying Yang; Jerome I Rotter; A Vidrich; Stephan R Targan
Perinuclear antineutrophil cytoplasmic antibodies in patients with Crohn's disease define a clinical subgroup.
Gastroenterology 1996;110(6):1810-9.
1996: ME Eggena; Stephan R Targan; L Iwanczyk; A Vidrich; Lynn K Gordon; Jonathan Braun
Phage display cloning and characterization of an immunogenetic marker (perinuclear anti-neutrophil cytoplasmic antibody) in ulcerative colitis.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(10):4005-11.
1996: William J Sandborn; Carol J Landers; William J Tremaine; Stephan R Targan
Association of antineutrophil cytoplasmic antibodies with resistance to treatment of left-sided ulcerative colitis: results of a pilot study.
Mayo Clinic proceedings. Mayo Clinic 1996;71(5):431-6.
1996: Scott Plevy; Stephan R Targan; Huiying Yang; D Fernandez; Jerome I Rotter; H Toyoda
Tumor necrosis factor microsatellites define a Crohn's disease-associated haplotype on chromosome 6.
Gastroenterology 1996;110(4):1053-60.
1996: Scott Plevy; Stephan R Targan
ANTI-TUMOR NECROSIS FACTOR-α THERAPY IN CROHN'S DISEASE: A MAGIC BULLET FINALLY HITS ITS MARK.
Inflammatory bowel diseases 1996;2(2):158-9.
1996: Maria T Abreu-Martin; Stephan R Targan
Regulation of immune responses of the intestinal mucosa.
Critical reviews in immunology 1996;16(3):277-309.
1995: BJ Zins; William J Sandborn; C R Penna; Carol J Landers; Stephan R Targan; William J Tremaine; R H Wiesner; R R Dozois
Pouchitis disease course after orthotopic liver transplantation in patients with primary sclerosing cholangitis and an ileal pouch-anal anastomosis.
The American journal of gastroenterology 1995;90(12):2177-81.
1995: Phillip R Fleshner; F Michelassi; M Rubin; S B Hanauer; Scott Plevy; Stephan R Targan
Morbidity of subtotal colectomy in patients with severe ulcerative colitis unresponsive to cyclosporin.
Diseases of the colon and rectum 1995;38(12):1241-5.
1995: Maria T Abreu-Martin; A Vidrich; D H Lynch; Stephan R Targan
Divergent induction of apoptosis and IL-8 secretion in HT-29 cells in response to TNF-alpha and ligation of Fas antigen.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(9):4147-54.
1995: W H Kim; P M Choi; Carol J Landers; Stephan R Targan
Role of antineutrophil cytoplasmic antibodies in an ethnically distinct population: Korean patients with ulcerative colitis.
The American journal of gastroenterology 1995;90(11):1953-8.
1995: Stephan R Targan; Carol J Landers; L Cobb; R P MacDermott; A Vidrich
Perinuclear anti-neutrophil cytoplasmic antibodies are spontaneously produced by mucosal B cells of ulcerative colitis patients.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(6):3262-7.
1995: Huiying Yang; D K Vora; Stephan R Targan; H Toyoda; Arthur L Beaudet; Jerome I Rotter
Intercellular adhesion molecule 1 gene associations with immunologic subsets of inflammatory bowel disease.
Gastroenterology 1995;109(2):440-8.
1995: William J Sandborn; Carol J Landers; William J Tremaine; Stephan R Targan
Antineutrophil cytoplasmic antibody correlates with chronic pouchitis after ileal pouch-anal anastomosis.
The American journal of gastroenterology 1995;90(5):740-7.
1995: Stephan R Targan; Carol J Landers; A Vidrich; A J Czaja
High-titer antineutrophil cytoplasmic antibodies in type-1 autoimmune hepatitis.
Gastroenterology 1995;108(4):1159-66.
1995: Stephan R Targan; Richard Deem; M Liu; S Wang; Andre E Nel
Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(2):664-75.
1994: L S Berberian; Y Valles-Ayoub; Lynn K Gordon; Stephan R Targan; Jonathan Braun
Expression of a novel autoantibody defined by the VH3-15 gene in inflammatory bowel disease and Campylobacter jejuni enterocolitis.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(8):3756-63.
1994: P M Choi; Stephan R Targan
Immunomodulator therapy in inflammatory bowel disease.
Digestive diseases and sciences 1994;39(9):1885-92.
1993: Huiying Yang; Jerome I Rotter; H Toyoda; Carol J Landers; D Tyran; C K McElree; Stephan R Targan
Ulcerative colitis: a genetically heterogeneous disorder defined by genetic (HLA class II) and subclinical (antineutrophil cytoplasmic antibodies) markers.
The Journal of clinical investigation 1993;92(2):1080-4.
1993: Huiying Yang; C McElree; M P Roth; F Shanahan; Stephan R Targan; Jerome I Rotter
Familial empirical risks for inflammatory bowel disease: differences between Jews and non-Jews.
Gut 1993;34(4):517-24.
1993: H Toyoda; S J Wang; H Y Yang; A Redford; D Magalong; Dolly Tyan; C K McElree; S R Pressman; F Shanahan; Stephan R Targan
Distinct associations of HLA class II genes with inflammatory bowel disease.
Gastroenterology 1993;104(3):741-8.
1992: F Shanahan; R H Duerr; Jerome I Rotter; Huiying Yang; L R Sutherland; C McElree; Carol J Landers; Stephan R Targan
Neutrophil autoantibodies in ulcerative colitis: familial aggregation and genetic heterogeneity.
Gastroenterology 1992;103(2):456-61.
1992: Stephan R Targan; Carol J Landers; N W King; D J Podolsky; F Shanahan
Ulcerative colitis-linked antineutrophil cytoplasmic antibody in the cotton-top tamarin model of colitis.
Gastroenterology 1992;102(5):1493-8.
1991: R H Duerr; Stephan R Targan; Carol J Landers; L R Sutherland; F Shanahan
Anti-neutrophil cytoplasmic antibodies in ulcerative colitis. Comparison with other colitides/diarrheal illnesses.
Gastroenterology 1991;100(6):1590-6.
1991: R H Duerr; Stephan R Targan; Carol J Landers; N F LaRusso; K L Lindsay; R H Wiesner; F Shanahan
Neutrophil cytoplasmic antibodies: a link between primary sclerosing cholangitis and ulcerative colitis.
Gastroenterology 1991;100(5 Pt 1):1385-91.
1991: F Shanahan; Carol J Landers; R Duerr; Stephan R Targan
Neutrophil autoantibodies as disease markers for ulcerative colitis.
Immunologic research 1991;10(3-4):479-84.
1991: Stephan R Targan; Richard Deem; F Shanahan
Role of mucosal T-cell-generated cytokines in epithelial cell injury.
Immunologic research 1991;10(3-4):472-8.
1991: Richard Deem; F Shanahan; Stephan R Targan
Triggered human mucosal T cells release tumour necrosis factor-alpha and interferon-gamma which kill human colonic epithelial cells.
Clinical and experimental immunology 1991;83(1):79-84.
1990: Richard Deem; Stephan R Targan; A Niederlehner; F Shanahan
The CD8+ Leu-7+ subset of T cells in Crohn's disease: distinction between cytotoxic and covert suppressor functions.
Clinical and experimental immunology 1990;80(3):387-94.
1989: L M Randolph; H Toyoda; C K McElree; F Shanahan; Stephan R Targan; Jerome I Rotter
Lack of an association between polymorphisms of the T-cell receptor alpha-chain and ulcerative colitis.
Gastroenterology 1989;97(5):1115-20.
1989: P A Anton; Stephan R Targan; F Shanahan
Increased neutrophil receptors for and response to the proinflammatory bacterial peptide formyl-methionyl-leucyl-phenylalanine in Crohn's disease.
Gastroenterology 1989;97(1):20-8.
1988: Richard Deem; F Shanahan; A Niederlehner; Stephan R Targan
Role of the CD45 (T-200) molecule in anti-CD3-triggered T cell-mediated cytotoxicity.
Cellular immunology 1988;117(1):99-110.
1988: P A Anton; Stephan R Targan; S R Vigna; M Durham; A D Schwabe; F Shanahan
Enhanced neutrophil chemiluminescence in familial Mediterranean fever.
Journal of clinical immunology 1988;8(2):148-56.
1988: L C Karp; Stephan R Targan
New enema treatments for inflammatory bowel disease.
Digestive diseases and sciences 1988;33(3 Suppl):85S-87S.
1987: Richard Deem; L J Britvan; Stephan R Targan
Definition of a secondary target cell trigger during natural killer cell cytotoxicity: possible role of phospholipase A2.
Cellular immunology 1987;110(2):253-64.
1987: M D Brogan; F Shanahan; M Oliver; R H Stevens; Stephan R Targan
Defective memory B cell formation in patients with inflammatory bowel disease following tetanus toxoid booster immunization.
Journal of clinical & laboratory immunology 1987;24(2):69-74.
1986: Richard Deem; A Niederlehner; Stephan R Targan
Active target cell processes, possibly involving receptor-mediated endocytosis, are critical for expression of cytotoxicity by natural killer cell-derived cytolytic factor.
Cellular immunology 1986;102(1):187-97.
1985: Richard Deem; Stephan R Targan
Analysis of sequential substages of the natural killer cell lethal hit.
Advances in experimental medicine and biology 1985;184():239-56.
1984: Richard Deem; Stephan R Targan
Sequential substages of natural killer cell-derived cytolytic factor (NKCF)-mediated cytolysis as defined by glutaraldehyde modulation of the target cell.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(4):1836-40.
1984: Richard Deem; Stephan R Targan
Evidence of a dynamic role of the target cell membrane during the early stages of the natural killer cell lethal hit.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(1):72-7.
1983: J C Hiserodt; L J Britvan; Stephan R Targan
Studies on the mechanism of the human natural killer cell lethal hit: evidence for transfer of protease-sensitive structures requisite for target cell lysis.
Journal of immunology (Baltimore, Md. : 1950) 1983;131(6):2710-3.
1983: J C Hiserodt; L Britvan; Stephan R Targan
Studies on the mechanism of the human natural killer cell lethal hit: analysis of the mechanism of protease inhibition of the lethal hit.
Journal of immunology (Baltimore, Md. : 1950) 1983;131(6):2705-9.
1982: J C Hiserodt; L J Britvan; Stephan R Targan
Inhibition of human natural killing by heterologous and monoclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1982;129(5):2248-54.
1982: J C Hiserodt; L J Britvan; Stephan R Targan
Differential effects of various pharmacological agents on the cytolytic reaction mechanism of the human natural killer lymphocyte: further resolution of programming for lysis and KCIL into discrete stages.
Journal of immunology (Baltimore, Md. : 1950) 1982;129(5):2266-70.
1982: J C Hiserodt; L J Britvan; Stephan R Targan
Characterization of the cytolytic reaction mechanism of the human natural killer (NK) lymphocyte: resolution into binding, programming, and killer cell-independent steps.
Journal of immunology (Baltimore, Md. : 1950) 1982;129(4):1782-7.