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Chris Tarling

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TOP 3
Georg Schitter; Andreas J Steiner; Gerit Pototschnig; Elisabeth Scheucher; Martin Thonhofer; Chris A Tarling; Stephen G Withers; Katrin Fantur; Eduard Paschke; Don J Mahuran; Brigitte A Rigat; Michael B Tropak; Carina Illaszewicz; Robert Saf; Arnold E Stütz; Tanja M Wrodnigg
Fluorous iminoalditols: a new family of glycosidase inhibitors and pharmacological chaperones.
Gerit Pototschnig; Christian Morales De Csáky; Jose R Montenegro Burke; Georg Schitter; Arnold E Stütz; Chris A Tarling; Stephen G Withers; Tanja M Wrodnigg
Synthesis and biological evaluation of novel biotin-iminoalditol conjugates.
James M Macdonald; Chris A Tarling; Edward J Taylor; Rebecca J Dennis; David S Myers; Spencer Knapp; Gideon J Davies; Stephen G Withers
Chitinase inhibition by chitobiose and chitotriose thiazolines.

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All Publications

2010: Georg Schitter; Andreas J Steiner; Gerit Pototschnig; Elisabeth Scheucher; Martin Thonhofer; Chris A Tarling; Stephen G Withers; Katrin Fantur; Eduard Paschke; Don J Mahuran; Brigitte A Rigat; Michael B Tropak; Carina Illaszewicz; Robert Saf; Arnold E Stütz; Tanja M Wrodnigg
Fluorous iminoalditols: a new family of glycosidase inhibitors and pharmacological chaperones.
Chembiochem : a European journal of chemical biology 2010;11(14):2026-33.
2010: Gerit Pototschnig; Christian Morales De Csáky; Jose R Montenegro Burke; Georg Schitter; Arnold E Stütz; Chris A Tarling; Stephen G Withers; Tanja M Wrodnigg
Synthesis and biological evaluation of novel biotin-iminoalditol conjugates.
Bioorganic & medicinal chemistry letters 2010;20(14):4077-9.
2010: James M Macdonald; Chris A Tarling; Edward J Taylor; Rebecca J Dennis; David S Myers; Spencer Knapp; Gideon J Davies; Stephen G Withers
Chitinase inhibition by chitobiose and chitotriose thiazolines.
Angewandte Chemie (International ed. in English) 2010;49(14):2599-602.
2010: Georg Schitter; Elisabeth Scheucher; Andreas J Steiner; Arnold E Stütz; Martin Thonhofer; Chris A Tarling; Stephen G Withers; Jacqueline Wicki; Katrin Fantur; Eduard Paschke; Don J Mahuran; Brigitte A Rigat; Michael Tropak; Tanja M Wrodnigg
Synthesis of lipophilic 1-deoxygalactonojirimycin derivatives as D-galactosidase inhibitors.
Beilstein journal of organic chemistry 2010;6():21.
2008: Andreas J Steiner; Georg Schitter; Arnold E Stütz; Tanja M Wrodnigg; Chris A Tarling; Stephen G Withers; Katrin Fantur; Don Mahuran; Eduard Paschke; Michael Tropak
1-Deoxygalactonojirimycin-lysine hybrids as potent D-galactosidase inhibitors.
Bioorganic & medicinal chemistry 2008;16(24):10216-20.
2008: Susan M Hancock; Chris A Tarling; Stephen G Withers
High-throughput screening of cell lysates for ganglioside synthesis.
Analytical biochemistry 2008;382(1):48-54.
2008: Douglas A Kuntz; Chris A Tarling; Stephen G Withers; David R Rose
Structural analysis of Golgi alpha-mannosidase II inhibitors identified from a focused glycosidase inhibitor screen.
Biochemistry 2008;47(38):10058-68.
2008: Andreas J Steiner; Arnold E Stütz; Tanja M Wrodnigg; Chris A Tarling; Stephen G Withers; Albin Hermetter; Hannes Schmidinger
Glycosidase profiling with immobilised glycosidase-inhibiting iminoalditols--a proof-of-concept study.
Bioorganic & medicinal chemistry letters 2008;18(6):1922-5.
2008: Chris A Tarling; Kate Woods; Ran Zhang; Harry C Brastianos; Gary D Brayer; Raymond J Andersen; Stephen G Withers
The search for novel human pancreatic alpha-amylase inhibitors: high-throughput screening of terrestrial and marine natural product extracts.
Chembiochem : a European journal of chemical biology 2008;9(3):433-8.
2007: Andreas J Steiner; Arnold E Stütz; Chris A Tarling; Stephen G Withers; Tanja M Wrodnigg
Iminoalditol-amino acid hybrids: synthesis and evaluation as glycosidase inhibitors.
Carbohydrate research 2007;342(12-13):1850-8.
2007: Mario Schubert; David K Y Poon; Jacqueline Wicki; Chris A Tarling; Emily M Kwan; Jens Nielsen; Stephen G Withers; Lawrence P McIntosh
Probing electrostatic interactions along the reaction pathway of a glycoside hydrolase: histidine characterization by NMR spectroscopy.
Biochemistry 2007;46(25):7383-95.
2007: Jacqueline Wicki; Johann Schloegl; Chris A Tarling; Stephen G Withers
Recruitment of both uniform and differential binding energy in enzymatic catalysis: xylanases from families 10 and 11.
Biochemistry 2007;46(23):6996-7005.
2007: Matthew E C Caines; Mark D Vaughan; Chris A Tarling; Susan M Hancock; R Antony J Warren; Stephen G Withers; Natalie C J Strynadka
Structural and mechanistic analyses of endo-glycoceramidase II, a membrane-associated family 5 glycosidase in the Apo and GM3 ganglioside-bound forms.
The Journal of biological chemistry 2007;282(19):14300-8.
2007: Matthew E C Caines; Susan M Hancock; Chris A Tarling; Tanja M Wrodnigg; Robert V Stick; Arnold E Stütz; Andrea Vasella; Stephen G Withers; Natalie C J Strynadka
The structural basis of glycosidase inhibition by five-membered iminocyclitols: the clan a glycoside hydrolase endoglycoceramidase as a model system.
Angewandte Chemie (International ed. in English) 2007;46(24):4474-6.
2006: Tanja M Wrodnigg; Arnold E Stütz; Chris A Tarling; Stephen G Withers
Fine tuning of beta-glucosidase inhibitory activity in the 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) system.
Carbohydrate research 2006;341(10):1717-22.
2006: Roni D Gordon; Prashanth Sivarajah; Malathy Satkunarajah; Dengbo Ma; Chris A Tarling; Dragos Vizitiu; Stephen G Withers; James M Rini
X-ray crystal structures of rabbit N-acetylglucosaminyltransferase I (GnT I) in complex with donor substrate analogues.
Journal of molecular biology 2006;360(1):67-79.
2006: Peter Greimel; Herwig Häusler; Inge Lundt; Karen Rupitz; Arnold E Stütz; Chris A Tarling; Stephen G Withers; Tanja M Wrodnigg
Fluorescent glycosidase inhibiting 1,5-dideoxy-1,5-iminoalditols.
Bioorganic & medicinal chemistry letters 2006;16(8):2067-70.
2006: Wendy Offen; Carlos Martinez-Fleites; Min Yang; Eng Kiat-Lim; Benjamin G Davis; Chris A Tarling; Christopher M Ford; Dianna J Bowles; Gideon J Davies
Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification.
The EMBO journal 2006;25(6):1396-405.
2006: Inge Lundt; Andreas J Steiner; Arnold E Stütz; Chris A Tarling; Stefan Ully; Stephen G Withers; Tanja M Wrodnigg
Fluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics.
Bioorganic & medicinal chemistry 2006;14(6):1737-42.
2005: Gillian Vandermeirsch; Chris A Tarling; Wade H Bingle; John F Nomellini; Mat Yamage; Irene R Dorocicz; Stephen G Withers; John Smit
Evaluation of a new system for developing particulate enzymes based on the surface (S)-layer protein (RsaA) of Caulobacter crescentus: fusion with the beta-1,4-glycanase (Cex) from the cellulolytic bacterium Cellulomonas fimi yields a robust, catalytically active product.
Applied biochemistry and biotechnology 2005;127(2):95-110.
2004: Tracey M Gloster; James M Macdonald; Chris A Tarling; Robert V Stick; Stephen G Withers; Gideon J Davies
Structural, thermodynamic, and kinetic analyses of tetrahydrooxazine-derived inhibitors bound to beta-glucosidases.
The Journal of biological chemistry 2004;279(47):49236-42.
2004: Chris A Tarling; Stephen G Withers
The synthesis of a series of modified mannotrisaccharides as probes of the enzymes involved in the early stages of mammalian complex N-glycan formation.
Carbohydrate research 2004;339(15):2487-97.
2004: Tracey M Gloster; Spencer J Williams; Shirley Roberts; Chris A Tarling; Jacqueline Wicki; Stephen G Withers; Gideon J Davies
Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A.
Chemical communications (Cambridge, England) 2004;(16):1794-5.
2004: Tanja M Wrodnigg; Frederik Diness; Christoph Gruber; Herwig Häusler; Inge Lundt; Karen Rupitz; Andreas J Steiner; Arnold E Stütz; Chris A Tarling; Stephen G Withers; Heidrun Wölfler
Probing the aglycon binding site of a beta-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors.
Bioorganic & medicinal chemistry 2004;12(13):3485-95.
2004: Gerlind Sulzenbacher; Christophe Bignon; Takeshi Nishimura; Chris A Tarling; Stephen G Withers; Bernard Henrissat; Yves Bourne
Crystal structure of Thermotoga maritima alpha-L-fucosidase. Insights into the catalytic mechanism and the molecular basis for fucosidosis.
The Journal of biological chemistry 2004;279(13):13119-28.
2004: Robert Gibson; Chris A Tarling; Shirley Roberts; Stephen G Withers; Gideon J Davies
The donor subsite of trehalose-6-phosphate synthase: binary complexes with UDP-glucose and UDP-2-deoxy-2-fluoro-glucose at 2 A resolution.
The Journal of biological chemistry 2004;279(3):1950-5.
2003: Chris A Tarling; Shouming He; Gerlind Sulzenbacher; Christophe Bignon; Yves Bourne; Bernard Henrissat; Stephen G Withers
Identification of the catalytic nucleophile of the family 29 alpha-L-fucosidase from Thermotoga maritima through trapping of a covalent glycosyl-enzyme intermediate and mutagenesis.
The Journal of biological chemistry 2003;278(48):47394-9.
2003: Valérie M-A Ducros; Chris A Tarling; David L Zechel; Andrzej M Brzozowski; Torben P Frandsen; Ingemar von Ossowski; Martin Schülein; Stephen G Withers; Gideon J Davies
Anatomy of glycosynthesis: structure and kinetics of the Humicola insolens Cel7B E197A and E197S glycosynthase mutants.
Chemistry & biology 2003;10(7):619-28.
2003: Annabelle Varrot; Chris A Tarling; James M Macdonald; Robert V Stick; David L Zechel; Stephen G Withers; Gideon J Davies
Direct observation of the protonation state of an imino sugar glycosidase inhibitor upon binding.
Journal of the American Chemical Society 2003;125(25):7496-7.
2003: Tracey M Gloster; Spencer J Williams; Chris A Tarling; Shirley Roberts; Claude Dupont; Pascalé Jodoin; François Shareck; Stephen G Withers; Gideon J Davies
A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer.
Chemical communications (Cambridge, England) 2003;(8):944-5.