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Giorgio Tarzia

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Alessio Lodola; Luigi Capoferri; Adrian Mulholland; Daniele Piomelli; Silvia Rivara; Giorgio Tarzia; Marco Mor
Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors.
Silvia Rivara; M Antonietta Stasi; Giorgio Tarzia; Francesca Bartoccini; Franco Borsini; Walter Cabri; Giuseppe Diamantini; Marco Mor; Daniele Pala; Giovanni Piersanti; Teresa Riccioni; Patrizia Minetti
Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.
Giorgio Tarzia
Editorial: premature publishing and over-fragmentation.

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All Publications

2013: Alessio Lodola; Luigi Capoferri; Adrian Mulholland; Daniele Piomelli; Silvia Rivara; Giorgio Tarzia; Marco Mor
Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors.
Journal of medicinal chemistry 2013;56(6):2500-12.
2013: Silvia Rivara; M Antonietta Stasi; Giorgio Tarzia; Francesca Bartoccini; Franco Borsini; Walter Cabri; Giuseppe Diamantini; Marco Mor; Daniele Pala; Giovanni Piersanti; Teresa Riccioni; Patrizia Minetti
Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.
Journal of medicinal chemistry 2013;56(3):1247-61.
2013: Giorgio Tarzia
Editorial: premature publishing and over-fragmentation.
ChemMedChem 2013;8(1):6-7.
2012: Rafael Ochoa-Sanchez; Quentin Rainer; Silvia Rivara; Gilberto Spadoni; Giorgio Tarzia; Annalida Bedini; Stefano Comai; Franco Fraschini; Marco Mor; Gabriella Gobbi
Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam.
Progress in neuro-psychopharmacology & biological psychiatry 2012;39(2):318-25.
2012: Francesca Bartoccini; Patrizia Minetti; Marco Mor; Giovanni Piersanti; Giorgio Tarzia; Walter Cabri
Divergent synthesis of novel 9-deazaxanthine derivatives via late-stage cross-coupling reactions.
Organic & biomolecular chemistry 2012;10(44):8860-7.
2011: Rafael Ochoa-Sanchez; Silvia Rivara; Gilberto Spadoni; Giorgio Tarzia; Baptiste Lacoste; Marco Mor; Debora Angeloni; Francis Bambico; Annalida Bedini; Stefano Comai; Laurent Descarries; Sergio Dominguez-Lopez; Franco Fraschini; Gabriella Gobbi
Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(50):18439-52.
2011: Federica Vacondio; Caterina Carmi; Jason R Clapper; Andrea Duranti; Alessio Lodola; Daniele Piomelli; Silvia Rivara; Silvano Sanchini; Claudia Silva; Giorgio Tarzia; Andrea Tontini; sha mor
Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability.
European journal of medicinal chemistry 2011;46(9):4466-73.
2011: Alessio Lodola; Luigi Capoferri; Silvia Rivara; Ewa Chudyk; Jitnapa Sirirak; Edyta Dyguda-Kazimierowicz; W Andrzej Sokalski; Mauro Mileni; Giorgio Tarzia; Daniele Piomelli; sha mor; Adrian J Mulholland
Understanding the role of carbamate reactivity in fatty acid amide hydrolase inhibition by QM/MM mechanistic modelling.
Chemical communications (Cambridge, England) 2011;47(9):2517-9.
2010: Jason R Clapper; Guillermo Moreno-Sanz; Roberto Russo; Ana Guijarro; Federica Vacondio; Andrea Duranti; Andrea Tontini; Silvano Sanchini; Natale R Sciolino; Jessica M Spradley; Andrea G Hohmann; Antonio Calignano; sha mor; Giorgio Tarzia; Daniele Piomelli
Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.
Nature neuroscience 2010;13(10):1265-70.
2010: Carlos Solorzano; Francesca Antonietti; Andrea Duranti; Andrea Tontini; Silvia Rivara; Alessio Lodola; Federica Vacondio; Giorgio Tarzia; Daniele Piomelli; sha mor
Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors.
Journal of medicinal chemistry 2010;53(15):5770-81.
2010: Francesca Bartoccini; Walter Cabri; Diana Celona; Patrizia Minetti; Giovanni Piersanti; Giorgio Tarzia
Direct B-alkyl Suzuki-Miyaura cross-coupling of 2-halopurines. Practical synthesis of ST1535, a potent adenosine A2A receptor antagonist.
The Journal of organic chemistry 2010;75(15):5398-401.
2010: sha mor; Silvia Rivara; Daniele Pala; Annalida Bedini; Gilberto Spadoni; Giorgio Tarzia
Recent advances in the development of melatonin MT(1) and MT(2) receptor agonists.
Expert opinion on therapeutic patents 2010;20(8):1059-77.
2009: Carlos Solorzano; Chenggang Zhu; Natalia Battista; Giuseppe Astarita; Alessio Lodola; Silvia Rivara; sha mor; Roberto Russo; Mauro Maccarrone; Francesca Antonietti; Andrea Duranti; Andrea Tontini; Salvatore Cuzzocrea; Giorgio Tarzia; Daniele Piomelli
Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(49):20966-71.
2009: Silvia Rivara; Federica Vacondio; Alessandro Fioni; Claudia Silva; Caterina Carmi; sha mor; Valeria Lucini; Marilou Pannacci; Alessia Caronno; Francesco Scaglione; Gabriella Gobbi; Gilberto Spadoni; Annalida Bedini; Pierfrancesco Orlando; Simone Lucarini; Giorgio Tarzia
N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands.
ChemMedChem 2009;4(10):1746-55.
2009: Jason R Clapper; Federica Vacondio; Alvin R King; Andrea Duranti; Andrea Tontini; Claudia Silva; Silvano Sanchini; Giorgio Tarzia; sha mor; Daniele Piomelli
A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo.
ChemMedChem 2009;4(9):1505-13.
2009: Federica Vacondio; Claudia Silva; Alessio Lodola; Alessandro Fioni; Silvia Rivara; Andrea Duranti; Andrea Tontini; Silvano Sanchini; Jason R Clapper; Daniele Piomelli; sha mor; Giorgio Tarzia
Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability.
ChemMedChem 2009;4(9):1495-504.
2009: Flavia Radogna; Laura Paternoster; Milena De Nicola; Claudia Cerella; Sergio Ammendola; Annalida Bedini; Giorgio Tarzia; Katia Aquilano; Maria Ciriolo; Lina Ghibelli
Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes.
Toxicology and applied pharmacology 2009;239(1):37-45.
2009: Jesse LoVerme; Andrea Duranti; Andrea Tontini; Gilberto Spadoni; sha mor; Silvia Rivara; Nephi Stella; Cong Xu; Giorgio Tarzia; Daniele Piomelli
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice.
Bioorganic & medicinal chemistry letters 2009;19(3):639-43.
2009: Francis Bambico; Andrea Duranti; Andrea Tontini; Giorgio Tarzia; Gabriella Gobbi
Endocannabinoids in the treatment of mood disorders: evidence from animal models.
Current pharmaceutical design 2009;15(14):1623-46.
2008: Alessio Lodola; sha mor; Silvia Rivara; Christo Christov; Giorgio Tarzia; Daniele Piomelli; Adrian J Mulholland
Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling.
Chemical communications (Cambridge, England) 2008;(2):214-6.
2008: Silvia Rivara; sha mor; Annalida Bedini; Gilberto Spadoni; Giorgio Tarzia
Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders.
Current topics in medicinal chemistry 2008;8(11):954-68.
2007: Silvia Rivara; Alessio Lodola; sha mor; Annalida Bedini; Gilberto Spadoni; Valeria Lucini; Marilou Pannacci; Franco Fraschini; Francesco Scaglione; Rafael Ochoa Sanchez; Gabriella Gobbi; Giorgio Tarzia
N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands.
Journal of medicinal chemistry 2007;50(26):6618-26.
2007: Alvin R King; Andrea Duranti; Andrea Tontini; Silvia Rivara; Anja Rosengarth; Jason R Clapper; Giuseppe Astarita; Jennifer A Geaga; Hartmut Luecke; sha mor; Giorgio Tarzia; Daniele Piomelli
URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices.
Chemistry & biology 2007;14(12):1357-65.
2007: Giovanni Valitutti; Andrea Duranti; Alessio Lodola; sha mor; Giovanni Piersanti; Daniele Piomelli; Silvia Rivara; Andrea Tontini; Giorgio Tarzia; Pietro Traldi
Correlation between energetics of collisionally activated decompositions, interaction energy and biological potency of carbamate FAAH inhibitors.
Journal of mass spectrometry : JMS 2007;42(12):1624-7.
2007: Gilberto Spadoni; Annalida Bedini; Giuseppe Diamantini; Giorgio Tarzia; Silvia Rivara; Simone Lorenzi; Alessio Lodola; sha mor; Valeria Lucini; Marilou Pannacci; Alessia Caronno; Franco Fraschini
Synthesis, enantiomeric resolution, and structure-activity relationship study of a series of 10,11-dihydro-5H-dibenzo[a,d]cycloheptene MT2 receptor antagonists.
ChemMedChem 2007;2(12):1741-9.
2007: Marco Bortolato; Regina A Mangieri; Jin Fu; Janet H Kim; Oliver Arguello; Andrea Duranti; Andrea Tontini; sha mor; Giorgio Tarzia; Daniele Piomelli
Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress.
Biological psychiatry 2007;62(10):1103-10.
2007: Giorgio Tarzia; Francesca Antonietti; Andrea Duranti; Andrea Tontini; sha mor; Silvia Rivara; Pietro Traldi; Giuseppe Astarita; Alvin King; Jason R Clapper; Daniele Piomelli
Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754).
Annali di chimica 2007;97(9):887-94.
2007: Flavia Radogna; Laura Paternoster; Maria Cristina Albertini; Claudia Cerella; Augusto Accorsi; Anahi Bucchini; Gilberto Spadoni; Giuseppe Diamantini; Giorgio Tarzia; Milena De Nicola; Maria D'Alessio; Lina Ghibelli
Melatonin antagonizes apoptosis via receptor interaction in U937 monocytic cells.
Journal of pineal research 2007;43(2):154-62.
2007: Giovanni Piersanti; Luca Giorgi; Francesca Bartoccini; Giorgio Tarzia; Patrizia Minetti; Grazia Gallo; Fabrizio Giorgi; Massimo Castorina; Orlando Ghirardi; Paolo Carminati
Synthesis of benzo[1,2-d;3,4-d']diimidazole and 1H-pyrazolo[4,3-b]pyridine as putative A2A receptor antagonists.
Organic & biomolecular chemistry 2007;5(16):2567-71.
2007: Barbara Di Giacomo; Annalida Bedini; Gilberto Spadoni; Giorgio Tarzia; Franco Fraschini; Marilou Pannacci; Valeria Lucini
Synthesis and biological activity of new melatonin dimeric derivatives.
Bioorganic & medicinal chemistry 2007;15(13):4643-50.
2007: Roberto Russo; Jesse LoVerme; Giovanna La Rana; Timothy R Compton; Jeff Parrott; Andrea Duranti; Andrea Tontini; sha mor; Giorgio Tarzia; Antonio Calignano; Daniele Piomelli
The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice.
The Journal of pharmacology and experimental therapeutics 2007;322(1):236-42.
2007: Alessio Lodola; sha mor; Jolanta Zurek; Giorgio Tarzia; Daniele Piomelli; Jeremy N Harvey; Adrian J Mulholland
Conformational effects in enzyme catalysis: reaction via a high energy conformation in fatty acid amide hydrolase.
Biophysical journal 2007;92(2):L20-2.
2006: Annalida Bedini; Gilberto Spadoni; Giuseppe Gatti; Simone Lucarini; Giorgio Tarzia; Silvia Rivara; Simone Lorenzi; Alessio Lodola; sha mor; Valeria Lucini; Marilou Pannacci; Francesco Scaglione
Design and synthesis of N-(3,3-diphenylpropenyl)alkanamides as a novel class of high-affinity MT2-selective melatonin receptor ligands.
Journal of medicinal chemistry 2006;49(25):7393-403.
2006: Jason R Clapper; Andrea Duranti; Andrea Tontini; sha mor; Giorgio Tarzia; Daniele Piomelli
The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues.
Pharmacological research : the official journal of the Italian Pharmacological Society 2006;54(5):341-4.
2006: Gilberto Spadoni; Annalida Bedini; Tomaso Guidi; Giorgio Tarzia; Valeria Lucini; Marilou Pannacci; Franco Fraschini
Towards the development of mixed MT(1)-agonist/MT(2)-antagonist melatonin receptor ligands.
ChemMedChem 2006;1(10):1099-105.
2006: Giuseppe Astarita; Barbara Di Giacomo; Silvana Gaetani; Fariba Oveisi; Timothy R Compton; Silvia Rivara; Giorgio Tarzia; sha mor; Daniele Piomelli
Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties.
The Journal of pharmacology and experimental therapeutics 2006;318(2):563-70.
2006: Silvia Rivara; Giuseppe Diamantini; Barbara Di Giacomo; Doriano Lamba; Giuseppe Gatti; Valeria Lucini; Marilou Pannacci; sha mor; Gilberto Spadoni; Giorgio Tarzia
Reassessing the melatonin pharmacophore--enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue.
Bioorganic & medicinal chemistry 2006;14(10):3383-91.
2006: Gilberto Spadoni; Giuseppe Diamantini; Annalida Bedini; Giorgio Tarzia; Federica Vacondio; Claudia Silva; Mirko Rivara; sha mor; Pier Vincenzo Plazzi; Morena Zusso; Davide Franceschini; Pietro Giusti
Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity.
Journal of pineal research 2006;40(3):259-69.
2006: Francesca Luchetti; Barbara Canonico; Rosa Curci; Michela Battistelli; Ferdinando Mannello; Stefano Papa; Giorgio Tarzia; Elisabetta Falcieri
Melatonin prevents apoptosis induced by UV-B treatment in U937 cell line.
Journal of pineal research 2006;40(2):158-67.
2006: Loris Tonidandel; Giorgio Tarzia; Francesca Antonietti; Andrea Vittadini; Pietro Traldi
On the formation of [H3C-S-S-CH3]+* ions from the bis(dimethylthio)mercury molecular ion.
Rapid communications in mass spectrometry : RCM 2006;20(20):3154-8.
2006: Giorgio Tarzia; Andrea Duranti; Giuseppe Gatti; Giovanni Piersanti; Andrea Tontini; Silvia Rivara; Alessio Lodola; Pier Vincenzo Plazzi; sha mor; Satish Kathuria; Daniele Piomelli
Synthesis and structure-activity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring.
ChemMedChem 2006;1(1):130-9.
2006: Daniele Piomelli; Giorgio Tarzia; Andrea Duranti; Andrea Tontini; sha mor; Timothy R Compton; Olivier Dasse; Edward P Monaghan; Jeff A Parrott; David Putman
Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).
CNS drug reviews 2006;12(1):21-38.
2005: Gabriella Gobbi; Francis Bambico; Regina A Mangieri; Marco Bortolato; Patrizia Campolongo; M Solinas; Tommaso Cassano; Maria Grazia Morgese; Guy Debonnel; Andrea Duranti; Andrea Tontini; Giorgio Tarzia; sha mor; Viviana Trezza; S R Goldberg; Vincenzo Cuomo; Daniele Piomelli
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18620-5.
2005: Patrizia Minetti; Maria Ornella Tinti; Paolo Carminati; Massimo Castorina; M Assunta Di Cesare; Stefano Di Serio; Grazia Gallo; Orlando Ghirardi; Fabrizio Giorgi; Luca Giorgi; Giovanni Piersanti; Francesca Bartoccini; Giorgio Tarzia
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Journal of medicinal chemistry 2005;48(22):6887-96.
2005: sha mor; Silvia Rivara; Alessio Lodola; Simone Lorenzi; Fabrizio Bordi; Pier Vincenzo Plazzi; Gilberto Spadoni; Annalida Bedini; Andrea Duranti; Andrea Tontini; Giorgio Tarzia
Application of 3D-QSAR in the rational design of receptor ligands and enzyme inhibitors.
Chemistry & biodiversity 2005;2(11):1438-51.
2005: Alessio Lodola; sha mor; Johannes C Hermann; Giorgio Tarzia; Daniele Piomelli; Adrian J Mulholland
QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation.
Chemical communications (Cambridge, England) 2005;(35):4399-401.
2005: Judit K Makara; sha mor; Darren Fegley; Szilárd I Szabó; Satish Kathuria; Giuseppe Astarita; Andrea Duranti; Andrea Tontini; Giorgio Tarzia; Silvia Rivara; Tamás F Freund; Daniele Piomelli
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus.
Nature neuroscience 2005;8(9):1139-41.
2005: Andrea G Hohmann; Richard L Suplita; Nathan M Bolton; Mark H Neely; Darren Fegley; Regina A Mangieri; Jocelyn F Krey; J Michael Walker; Philip V Holmes; Jonathon D Crystal; Andrea Duranti; Andrea Tontini; sha mor; Giorgio Tarzia; Daniele Piomelli
An endocannabinoid mechanism for stress-induced analgesia.
Nature 2005;435(7045):1108-12.
2005: Silvia Rivara; Simone Lorenzi; sha mor; Pier Vincenzo Plazzi; Gilberto Spadoni; Annalida Bedini; Giorgio Tarzia
Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models.
Journal of medicinal chemistry 2005;48(12):4049-60.
2005: Darren Fegley; Silvana Gaetani; Andrea Duranti; Andrea Tontini; sha mor; Giorgio Tarzia; Daniele Piomelli
Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation.
The Journal of pharmacology and experimental therapeutics 2005;313(1):352-8.
2004: Elisa Basso; Andrea Duranti; sha mor; Daniele Piomelli; Andrea Tontini; Giorgio Tarzia; Pietro Traldi
Tandem mass spectrometric data-FAAH inhibitory activity relationships of some carbamic acid O-aryl esters.
Journal of mass spectrometry : JMS 2004;39(12):1450-5.
2004: sha mor; Silvia Rivara; Alessio Lodola; Pier Vincenzo Plazzi; Giorgio Tarzia; Andrea Duranti; Andrea Tontini; Giovanni Piersanti; Satish Kathuria; Daniele Piomelli
Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies.
Journal of medicinal chemistry 2004;47(21):4998-5008.
2004: Valeria Lucini; Marilou Pannacci; Francesco Scaglione; Franco Fraschini; Silvia Rivara; sha mor; Fabrizio Bordi; Pier Vincenzo Plazzi; Gilberto Spadoni; Annalida Bedini; Giovanni Piersanti; Giuseppe Diamantini; Giorgio Tarzia
Tricyclic alkylamides as melatonin receptor ligands with antagonist or inverse agonist activity.
Journal of medicinal chemistry 2004;47(17):4202-12.
2004: sha mor; Claudia Silva; Federica Vacondio; Pier Vincenzo Plazzi; Simona Bertoni; Gilberto Spadoni; Giuseppe Diamantini; Annalida Bedini; Giorgio Tarzia; Morena Zusso; Davide Franceschini; Pietro Giusti
Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities.
Journal of pineal research 2004;36(2):95-102.
2003: Sabrina Burattini; Francesca Luchetti; Michela Battistelli; M Della Felice; Stefano Papa; Giovanni Piersanti; Giorgio Tarzia; Elisabetta Falcieri
5-(2-Ethyl-phenyl)-3-(3-methoxy-phenyl)-1H-[1,2,4]triazole (DL-111-IT) and related compounds induce apoptotic patterns in cultures of human tumor cell lines.
Journal of biological regulators and homeostatic agents 2003;17(4):348-57.
2003: Fabrizio Micheli; Romano Di Fabio; Paolo Cavanni; Daniele Donati; Stefania Faedo; Sylvie Gehanne; Micaela Maffeis; Carla Marchioro; Fabio Maria Sabbatini; Giorgio Tarzia; Maria Elvira Tranquillini; Monica Valeria Angela Viziano
2,4-Dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists: an exploration of the role of the pyrrolic scaffold.
Farmaco (Società chimica italiana : 1989) 2003;58(10):1005-9.
2003: Jin Fu; Silvana Gaetani; Fariba Oveisi; Jesse Lo Verme; Antonia Serrano; Fernando Rodríguez de Fonseca; Anja Rosengarth; Hartmut Luecke; Barbara Di Giacomo; Giorgio Tarzia; Daniele Piomelli
Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha.
Nature 2003;425(6953):90-3.
2003: Giorgio Tarzia; Andrea Duranti; Andrea Tontini; Gilberto Spadoni; sha mor; Silvia Rivara; Pier Vincenzo Plazzi; Satish Kathuria; Daniele Piomelli
Synthesis and structure-activity relationships of a series of pyrrole cannabinoid receptor agonists.
Bioorganic & medicinal chemistry 2003;11(18):3965-73.
2003: Fabrizio Micheli; Romano Di Fabio; Fabio Bordi; Palmina Cavallini; Paolo Cavanni; Daniele Donati; Stefania Faedo; Micaela Maffeis; Fabio Maria Sabbatini; Giorgio Tarzia; Maria Elvira Tranquillini
2,4-Dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists: further characterization of 3,5-dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester and structure-activity relationships.
Bioorganic & medicinal chemistry letters 2003;13(13):2113-8.
2003: Giorgio Tarzia; Andrea Duranti; Andrea Tontini; Giovanni Piersanti; sha mor; Silvia Rivara; Pier Vincenzo Plazzi; Chris Park; Satish Kathuria; Daniele Piomelli
Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.
Journal of medicinal chemistry 2003;46(12):2352-60.
2003: Silvia Rivara; sha mor; Claudia Silva; Valentina Zuliani; Federica Vacondio; Gilberto Spadoni; Annalida Bedini; Giorgio Tarzia; Valeria Lucini; Marilou Pannacci; Franco Fraschini; Pier Vincenzo Plazzi
Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation.
Journal of medicinal chemistry 2003;46(8):1429-39.
2003: Gilberto Spadoni; Annalida Bedini; Giovanni Piersanti; sha mor; Silvia Rivara; Giorgio Tarzia
Strategies leading to MT2 selective melatonin receptor antagonists.
Advances in experimental medicine and biology 2003;527():577-85.
2003: sha mor; Gilberto Spadoni; Giuseppe Diamantini; Annalida Bedini; Giorgio Tarzia; Claudia Silva; Federica Vacondio; Mirko Rivara; Pier Vincenzo Plazzi; Davide Franceschini; Morena Zusso; Pietro Giusti
Antioxidant and cytoprotective activity of indole derivatives related to melatonin.
Advances in experimental medicine and biology 2003;527():567-75.
2003: Satish Kathuria; Silvana Gaetani; Darren Fegley; Fernando Valiño; Andrea Duranti; Andrea Tontini; sha mor; Giorgio Tarzia; Giovanna La Rana; Antonio Calignano; Arcangela Giustino; Maria Tattoli; Maura Palmery; Vincenzo Cuomo; Daniele Piomelli
Modulation of anxiety through blockade of anandamide hydrolysis.
Nature medicine 2003;9(1):76-81.
2002: Annalida Bedini; C Balsamini; Barbara Di Giacomo; Andrea Tontini; B Citterio; Luca Giorgi; Enza Di Modugno; Giorgio Tarzia
Synthesis and biological evaluation of 6-bromo-6-substituted penicillanic acid derivatives as beta-lactamase inhibitors.
Farmaco (Società chimica italiana : 1989) 2002;57(8):663-9.
2002: Piero Sestili; Giuseppe Diamantini; Annalida Bedini; Liana Cerioni; Ilaria Tommasini; Giorgio Tarzia; Orazio Cantoni
Plant-derived phenolic compounds prevent the DNA single-strand breakage and cytotoxicity induced by tert-butylhydroperoxide via an iron-chelating mechanism.
The Biochemical journal 2002;364(Pt 1):121-8.
2002: Katarzyna Winczyk; Marek Pawlikowski; Hanna Lawnicka; Jolanta Kunert-Radek; Gilberto Spadoni; Giorgio Tarzia; Michal Karasek
Effects of melatonin and melatonin receptors ligand N-[(4-methoxy-1H-indol-2-yl)methyl]propanamide on murine Colon 38 cancer growth in vitro and in vivo.
Neuro endocrinology letters 2002;23 Suppl 1():50-4.
2002: Barbara Di Giacomo; Giorgio Tarzia; Annalida Bedini; Giuseppe Gatti; Francesca Bartoccini; C Balsamini; Andrea Tontini; W Baffone; Enza Di Modugno; A Felici
Synthesis of new C-6 alkyliden penicillin derivatives as beta-lactamase inhibitors.
Farmaco (Società chimica italiana : 1989) 2002;57(4):273-83.
2001: Gilberto Spadoni; C Balsamini; Giuseppe Diamantini; Andrea Tontini; Giorgio Tarzia; sha mor; Silvia Rivara; Pier Vincenzo Plazzi; R Nonno; Valeria Lucini; Marilou Pannacci; Franco Fraschini; BM Stankov
2-N-acylaminoalkylindoles: design and quantitative structure-activity relationship studies leading to MT2-selective melatonin antagonists.
Journal of medicinal chemistry 2001;44(18):2900-12.
2001: sha mor; Gilberto Spadoni; Barbara Di Giacomo; Giuseppe Diamantini; Annalida Bedini; Giorgio Tarzia; Pier Vincenzo Plazzi; Silvia Rivara; R Nonno; Valeria Lucini; Marilou Pannacci; Franco Fraschini; BM Stankov
Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands.
Bioorganic & medicinal chemistry 2001;9(4):1045-57.
2000: R Nonno; Valeria Lucini; Gilberto Spadoni; Marilou Pannacci; A Croce; D Esposti; C Balsamini; Giorgio Tarzia; Franco Fraschini; BM Stankov
A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties.
Journal of pineal research 2000;29(4):234-40.
2000: A Ursini; Anna Maria Capelli; R A Carr; P Cassarà; Mauro Corsi; O Curcuruto; G Curotto; M Dal Cin; Silvia Davalli; Daniele Donati; Aldo Feriani; H Finch; G Finizia; Giovanni Gaviraghi; M Marien; Giorgio Pentassuglia; S Polinelli; Emiliangelo Ratti; Angelo Reggiani; Giorgio Tarzia; Giovanna Tedesco; Maria Elvira Tranquillini; David G Trist; FT van Amsterdam; A Reggiani
Synthesis and SAR of new 5-phenyl-3-ureido-1,5-benzodiazepines as cholecystokinin-B receptor antagonists.
Journal of medicinal chemistry 2000;43(20):3596-613.
2000: Giorgio Tarzia; Giuseppe Diamantini; sha mor; Gilberto Spadoni
Design and synthesis of melatonin receptors agonists and antagonists.
Farmaco (Società chimica italiana : 1989) 2000;55(3):184-7.
1999: sha mor; Pier Vincenzo Plazzi; Gilberto Spadoni; Giorgio Tarzia
Melatonin.
Current medicinal chemistry 1999;6(6):501-18.
1999: C Balsamini; Annalida Bedini; Giuseppe Diamantini; Gilberto Spadoni; Giorgio Tarzia; Andrea Tontini; Romano Di Fabio; D Donati
3-(2-Carbamoylvinyl)-4,5-dimethylpyrrole-2-carboxylic acids as ligands at the NMDA glycine-binding site: a study on the 2-carbamoylvinyl chain modification.
Farmaco (Società chimica italiana : 1989) 1999;54(1-2):101-11.
1999: Giorgio Tarzia; Giuseppe Diamantini; Gilberto Spadoni
Indole melatonin agonists and antagonists derived by shifting the melatonin side chain from the C-3 to the N-1 or to the C-2 indole position.
Biological signals and receptors 1999;8(1-2):24-31.
1999: Gilberto Spadoni; sha mor; Giorgio Tarzia
Structure-affinity relationships of indole-based melatonin analogs.
Biological signals and receptors 1999;8(1-2):15-23.
1998: sha mor; Silvia Rivara; Claudia Silva; Fabrizio Bordi; Pier Vincenzo Plazzi; Gilberto Spadoni; Giuseppe Diamantini; C Balsamini; Giorgio Tarzia; Franco Fraschini; Valeria Lucini; R Nonno; BM Stankov
Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study.
Journal of medicinal chemistry 1998;41(20):3831-44.
1998: Gilberto Spadoni; C Balsamini; Annalida Bedini; Giuseppe Diamantini; Barbara Di Giacomo; Andrea Tontini; Giorgio Tarzia; sha mor; Pier Vincenzo Plazzi; Silvia Rivara; R Nonno; Marilou Pannacci; Valeria Lucini; Franco Fraschini; BM Stankov
2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists.
Journal of medicinal chemistry 1998;41(19):3624-34.
1998: C Balsamini; Annalida Bedini; Giuseppe Diamantini; Gilberto Spadoni; Andrea Tontini; Giorgio Tarzia; Romano Di Fabio; Aldo Feriani; Angelo Reggiani; Giovanna Tedesco; R Valigi
(E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists.
Journal of medicinal chemistry 1998;41(6):808-20.
1998: C Balsamini; Annalida Bedini; Gilberto Spadoni; Giorgio Tarzia; Andrea Tontini; Walter Balduini; Mauro Cimino
1-Aminocylopropane-1-carboxylic acid derivatives as ligands at the glycine-binding site of the N-methyl-D-aspartate receptor.
Farmaco (Società chimica italiana : 1989) 1998;53(3):181-8.
1998: G Finizia; Daniele Donati; Giorgio Pentassuglia; S Polinelli; Giorgio Tarzia; Maria Elvira Tranquillini; A Ursini
Synthesis and evaluation of 1,5-benzodiazepines with bridged cycloalkyl substituents at the N-1 position as potent and selective CCK-B Ligands.
Archiv der Pharmazie 1998;331(1):41-4.
1997: Fabrizio Micheli; A Cugola; Daniele Donati; Andrea Missio; Angelo Pecunioso; Angelo Reggiani; Giorgio Tarzia
2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity.
Bioorganic & medicinal chemistry 1997;5(12):2129-32.
1997: Maria Elvira Tranquillini; P G Cassarà; Mauro Corsi; G Curotto; Daniele Donati; G Finizia; Giorgio Pentassuglia; S Polinelli; Giorgio Tarzia; A Ursini; FT van Amsterdam
Novel 1,5-benzodiazepines as CCK-B ligands. Effect of aryl-carbamic substituents at the C-3 position together with halogen substitution on the benzo-fused ring.
Archiv der Pharmazie 1997;330(11):353-7.
1997: Giorgio Tarzia; Giuseppe Diamantini; Barbara Di Giacomo; Gilberto Spadoni; D Esposti; R Nonno; Valeria Lucini; Marilou Pannacci; Franco Fraschini; BM Stankov
1-(2-Alkanamidoethyl)-6-methoxyindole derivatives: a new class of potent indole melatonin analogues.
Journal of medicinal chemistry 1997;40(13):2003-10.
1997: Gilberto Spadoni; C Balsamini; Giuseppe Diamantini; Barbara Di Giacomo; Giorgio Tarzia; sha mor; Pier Vincenzo Plazzi; Silvia Rivara; Valeria Lucini; R Nonno; Marilou Pannacci; Franco Fraschini; BM Stankov
Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study.
Journal of medicinal chemistry 1997;40(13):1990-2002.
1996: Giovanni Gaviraghi; A Perboni; B Tamburini; L Xerri; A Salvatori; Gilberto Spadoni; Giorgio Tarzia
Synthesis and antimicrobial evaluation of 2 beta-chloromethyl-6 beta-carbamoylmethyl-penam-1,1-dioxide-3-carboxylic acid.
Farmaco (Società chimica italiana : 1989) 1996;51(7):535-8.
1996: G Araldi; Daniele Donati; Beatrice Oliosi; A Ursini; FT van Amsterdam; Benedetto Natalini; Roberto Pellicciari; Giorgio Tarzia
Synthesis and receptor binding affinity of cholecystokinin receptor ligands: 2-and 1-indolyl derivatives of PD134308.
Farmaco (Società chimica italiana : 1989) 1996;51(7):471-6.
1995: Giorgio Pentassuglia; Giorgio Tarzia; D Andreotti; C Bismara; R Carlesso; Daniele Donati; Giovanni Gaviraghi; A Perboni; A Pezzoli; T Rossi
Synthesis of novel 6-alpha and 6-beta-alkylcarbonylmethyl substituted penems.
The Journal of antibiotics 1995;48(5):399-407.
1993: C Bassini; C Bismara; R Carlesso; Aldo Feriani; Giovanni Gaviraghi; Carla Marchioro; A Perboni; R E Shaw; B Tamburini; Giorgio Tarzia
Synthesis and antimicrobial activity of DNA-gyrase inhibiting derivatives of 4-oxo-1,4-dihydro-3-pyridinecarboxylic acid.
Farmaco (Società chimica italiana : 1989) 1993;48(2):159-89.
1989: M Scandola; Giorgio Tarzia; Giovanni Gaviraghi; D Chiarello; Pietro Traldi
Mass spectrometric approaches in structural characterization of cephalosporins.
Biomedical & environmental mass spectrometry 1989;18(10):851-4.