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Ryo Tatsumi

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Ryo Tatsumi; Masakazu Fujio; Shin-ichi Takanashi; Atsushi Numata; Jiro Katayama; Hiroyuki Satoh; Yasuyuki Shiigi; Jun-ichi Maeda; Makoto Kuriyama; Takashi Horikawa; Takahiro Murozono; Kenji Hashimoto; Hiroshi Tanaka
(R)-3'-(3-methylbenzo[b]thiophen-5-yl)spiro[1-azabicyclo[2,2,2]octane-3,5'-oxazolidin]-2'-one, a novel and potent alpha7 nicotinic acetylcholine receptor partial agonist displays cognitive enhancing properties.
Mikako Ogawa; Ryo Tatsumi; Masakazu Fujio; Jiro Katayama; Yasuhiro Magata
Synthesis and evaluation of [125I]I-TSA as a brain nicotinic acetylcholine receptor alpha7 subtype imaging agent.
Ryo Tatsumi; Masakazu Fujio; Hiroyuki Satoh; Jiro Katayama; Shin-Ichi Takanashi; Kenji Hashimoto; Hiroshi Tanaka
Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand.

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All Publications

2006: Ryo Tatsumi; Masakazu Fujio; Shin-ichi Takanashi; Atsushi Numata; Jiro Katayama; Hiroyuki Satoh; Yasuyuki Shiigi; Jun-ichi Maeda; Makoto Kuriyama; Takashi Horikawa; Takahiro Murozono; Kenji Hashimoto; Hiroshi Tanaka
(R)-3'-(3-methylbenzo[b]thiophen-5-yl)spiro[1-azabicyclo[2,2,2]octane-3,5'-oxazolidin]-2'-one, a novel and potent alpha7 nicotinic acetylcholine receptor partial agonist displays cognitive enhancing properties.
Journal of medicinal chemistry 2006;49(14):4374-83.
2006: Mikako Ogawa; Ryo Tatsumi; Masakazu Fujio; Jiro Katayama; Yasuhiro Magata
Synthesis and evaluation of [125I]I-TSA as a brain nicotinic acetylcholine receptor alpha7 subtype imaging agent.
Nuclear medicine and biology 2006;33(3):311-6.
2005: Ryo Tatsumi; Masakazu Fujio; Hiroyuki Satoh; Jiro Katayama; Shin-Ichi Takanashi; Kenji Hashimoto; Hiroshi Tanaka
Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand.
Journal of medicinal chemistry 2005;48(7):2678-86.
2004: Ryo Tatsumi; Kohji Seio; Masakazu Fujio; Jiro Katayama; Takashi Horikawa; Kenji Hashimoto; Hiroshi Tanaka
(+)-3-[2-(Benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane as potent agonists for the alpha7 nicotinic acetylcholine receptor.
Bioorganic & medicinal chemistry letters 2004;14(14):3781-4.

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