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Jan Borén

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Chemicals & Drugs

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Physiology

Lipid Metabolism

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Cristina Maglio; Rosellina Margherita Mancina; Tiziana Montalcini; Marju Orho-Melander; Carlo Pirazzi; Arturo Pujia; Johanna Andersson Assarsson; Marco Giorgio Baroni; Jan Borén; Maria Antonella Burza; Lena M S Carlsson; Ulrika Ericson; Kajsa Sjöholm; Lars Sjöström; Per-Arne Svensson; Olov Wiklund; Stefano Romeo
The IRS1 rs2943641 Variant and Risk of Future Cancer Among Morbidly Obese Individuals.
Christina Drevinge; Lars Grip; Lars O Karlsson; Thomas Larsson; Linda Andersson; Jan Borén; Jeanna Perman Sundelin; Marcus Ståhlman; Malin C Levin
Cholesteryl esters accumulate in the heart in a porcine model of ischemia and reperfusion.
Lu Li; Mikael Rutberg; Marcus Ståhlman; Linda Andersson; Per Fogelstrand; Liljana Håversen; Malin Levin; Jan Borén
ARF6 Regulates Neuron Differentiation through Glucosylceramide Synthase.

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2013: Cristina Maglio; Rosellina Margherita Mancina; Tiziana Montalcini; Marju Orho-Melander; Carlo Pirazzi; Arturo Pujia; Johanna Andersson Assarsson; Marco Giorgio Baroni; Jan Borén; Maria Antonella Burza; Lena M S Carlsson; Ulrika Ericson; Kajsa Sjöholm; Lars Sjöström; Per-Arne Svensson; Olov Wiklund; Stefano Romeo
The IRS1 rs2943641 Variant and Risk of Future Cancer Among Morbidly Obese Individuals.
The Journal of clinical endocrinology and metabolism 2013;98(4):E785-9.
2013: Christina Drevinge; Lars Grip; Lars O Karlsson; Thomas Larsson; Linda Andersson; Jan Borén; Jeanna Perman Sundelin; Marcus Ståhlman; Malin C Levin
Cholesteryl esters accumulate in the heart in a porcine model of ischemia and reperfusion.
PloS one 2013;8(4):e61942.
2013: Lu Li; Mikael Rutberg; Marcus Ståhlman; Linda Andersson; Per Fogelstrand; Liljana Håversen; Malin Levin; Jan Borén
ARF6 Regulates Neuron Differentiation through Glucosylceramide Synthase.
PloS one 2013;8(3):e60118.
2013: Björn Fagerberg; Göran Bergström; Jan Borén; Lars Barregard
Cadmium exposure, intercellular adhesion molecule-1 and peripheral artery disease: a cohort and an experimental study.
BMJ open 2013;3(3):.
2013: Yangzhen Shao; Marcus Ståhlman; Sebastian Szardien; Margareta Scharin Täng; Christian Troidl; Jan Borén; Christian Hamm; Azra Miljanovic; Helge Möllmann; Holger Nef; Björn Redfors; Elmir Omerovic
A mouse model reveals an important role for catecholamine-induced lipotoxicity in the pathogenesis of stress-induced cardiomyopathy.
European journal of heart failure 2013;15(1):9-22.
2012: Carlo Pirazzi; Arturo Pujia; Marcus Ståhlman; Marja-Riitta Taskinen; Olov Wiklund; Martin Adiels; Linda Andersson; Jan Borén; Maria Antonella Burza; Malin Levin; Cristina Maglio; Rosellina Margherita Mancina; Tiziana Montalcini; Marju Orho-Melander; Jeanna Perman; Stefano Romeo
Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro.
Journal of hepatology 2012;57(6):1276-82.
2012: Björn Fagerberg; Göran Bergström; Jan Borén; Lars Barregard
Cadmium exposure is accompanied by increased prevalence and future growth of atherosclerotic plaques in 64-year-old women.
Journal of internal medicine 2012;272(6):601-10.
2012: Maria Antonella Burza; Lena Mariana Susann Carlsson; Stefano Ginanni-Corradini; Peter Jacobson; Cristina Maglio; Rosellina Margherita Mancina; Tiziana Montalcini; Carlo Pirazzi; Martin Adiels; Marco Giorgio Baroni; Jan Borén; Kajsa Sjöholm; Lars Sjöström; Per-Arne Svensson; Stefano Romeo
PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2012;44(12):1037-41.
2012: M C Levin; S Li; U Lidberg; MacRae F Linton; Sven-Olof Olofsson; A Wramstedt; Martin Adiels; Jan Borén; S Fazio; D R Greaves; K Gustafsson; Pernilla Jirholt; Inger Gjertsson
Evaluation of macrophage-specific promoters using lentiviral delivery in mice.
Gene therapy 2012;19(11):1041-7.
2012: Karin Åström-Olsson; Hans Öhlin; Jan Borén; Lizhen Li; Charlotta S Olofsson; Lars Grip
Impact of hypoxia, simulated ischemia and reperfusion in HL-1 cells on the expression of FKBP12/FKBP12.6 and intracellular calcium dynamics.
Biochemical and biophysical research communications 2012;422(4):732-8.
2012: Sven-Olof Olofsson; Jan Borén
Apolipoprotein B secretory regulation by degradation.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(6):1334-8.
2012: Martin Adiels; Jan Borén; Thomas Larsson; Niina Matikainen; Sven-Olof Olofsson; Sanni Söderlund; Jukka Westerbacka; Marja-Riitta Taskinen
Postprandial accumulation of chylomicrons and chylomicron remnants is determined by the clearance capacity.
Atherosclerosis 2012;222(1):222-8.
2012: Truls Råmunddal; Yangzhen Shao; Margareta Scharin Täng; Jan Borén; Malin Lindbom; Elmir Omerovic
Overexpression of apolipoprotein B attenuates pathologic cardiac remodeling and hypertrophy in response to catecholamines and after myocardial infarction in mice.
Scandinavian journal of clinical and laboratory investigation 2012;72(3):230-6.
2012: Jan Borén; Marja-Riitta Taskinen; Martin Adiels
Kinetic studies to investigate lipoprotein metabolism.
Journal of internal medicine 2012;271(2):166-73.
2012: Jeanna Perman Sundelin; Malin E V Johansson; Max Levin; Annika Lundqvist; Paolo Parini; Marcus Ståhlman; Jan Borén
Increased expression of the very low-density lipoprotein receptor mediates lipid accumulation in clear-cell renal cell carcinoma.
PloS one 2012;7(11):e48694.
2012: Lisa U Magnusson; Kristina Skålén; Olov Wiklund; Jan Borén; Merja Nurkkala Karlsson; Max Levin; Annika Lundqvist; Lillemor Mattsson Hultén
Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis.
PloS one 2012;7(8):e43142.
2012: Lu Li; Bo Liu; Emma Lu; Lisa U Magnusson; Marcus Ståhlman; Göran Bergström; Jan Borén; Liljana Håversen; Malin C Levin; Lillemor Mattsson Hultén
The importance of GLUT3 for de novo lipogenesis in hypoxia-induced lipid loading of human macrophages.
PloS one 2012;7(8):e42360.
2012: Rajesh K Nallapalli; David Pazooki; Björn Redfors; Sai Naresh Sunkara; Yin Zhang; Alex X Zhou; Sashidar Bandaru; Martin O Bergo; Jan Borén; Yihai Cao; Mohamed X Ibrahim; Levent M Akyürek
Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in mice.
Molecular cancer 2012;11():50.
2012: Sigfus Gizurarson; Azra Miljanovic; Lennart Bergfeldt; Jan Borén; Truls Råmunddal; Yangzhen Shao; Elmir Omerovic
Electrophysiological effects of lysophosphatidylcholine on HL-1 cardiomyocytes assessed with a microelectrode array system.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;30(2):477-88.
2012: Colin N A Palmer; Ewan R Pearson; Markku Peltonen; Carlo Pirazzi; Lars Sjöström; Per-Arne Svensson; Martin Adiels; Jan Borén; Lindsay Burch; Maria Antonella Burza; Lena M S Carlsson; Helen Colhoun; John F Dillon; Alexander S Doney; Louise A Donnelly; Tim Frayling; Andrew T Hattersley; Peter Jacobson; Cristina Maglio; Mark McCarthy; Andrew D Morris; Stefano Romeo
Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.
PloS one 2012;7(6):e39362.
2011: Malin C Levin; Anna M Lundberg; Sven-Olof Olofsson; Marcus Ståhlman; Maria Gustafsson Trajkovska; Anna Wramstedt; Zhong-Qun Yan; Mikael Brisslert; Linda Fogelstrand; Per Fogelstrand; Göran K Hansson; Pernilla Jirholt; Maria E Johansson; Harry Björkbacka; Jan Borén
Rip2 deficiency leads to increased atherosclerosis despite decreased inflammation.
Circulation research 2011;109(11):1210-8.
2011: Sven-Olof Olofsson; Christina Olsson; Mikael Rutberg; Linda Andersson; Jan Borén; Liliana Håversen; Lu Li; Emma Lu; Reza Mobini; Susanna Myhre; Pontus Boström
The formation of lipid droplets: possible role in the development of insulin resistance/type 2 diabetes.
Prostaglandins, leukotrienes, and essential fatty acids 2011;85(5):215-8.
2011: Marja-Riitta Taskinen; Jukka Westerbacka; Martin Adiels; Antti Hakkarainen; Juhani Kahri; Jesper Lundbom; Nina Lundbom; Sven-Olof Olofsson; Marju Orho-Melander; Sanni Söderlund; Jan Borén
Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(9):2144-50.
2011: Vilborg Palsdottir; Birgitta Strandvik; Jan Borén; Bob Olsson; Britt G Gabrielsson
Postnatal essential fatty acid deficiency in mice affects lipoproteins, hepatic lipids, fatty acids and mRNA expression.
Prostaglandins, leukotrienes, and essential fatty acids 2011;85(3-4):179-88.
2011: Jeanna C Perman; Petur Petursson; Margareta Scharin Täng; Marcus StÅhlman; Dudley K Strickland; Pontus Boström; Kim Ekroos; Daniel Hägg; Johan Herlitz; Anders Jeppsson; Ulf Lidberg; Malin Lindbom; Henrik Lindskog; Lillemor Mattsson-Hultén; Gunilla Olivecrona; Sven-Olof Olofsson; Elmir Omerovic; Jan Borén
The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction.
The Journal of clinical investigation 2011;121(7):2625-40.
2011: Alex-Xianghua Zhou; Aslı Toylu; Rajesh K Nallapalli; Gisela Nilsson; Neşe Atabey; Carl-Henrik Heldin; Jan Borén; Martin O Bergo; Levent M Akyürek
Filamin a mediates HGF/c-MET signaling in tumor cell migration.
International journal of cancer. Journal international du cancer 2011;128(4):839-46.
2011: Maja Olsson; Sofie Ahlin; Bob Olsson; Per-Arne Svensson; Marcus Ståhlman; Jan Borén; Lena Carlsson; Kajsa Sjöholm
Establishment of a transgenic mouse model specifically expressing human serum amyloid A in adipose tissue.
PloS one 2011;6(5):e19609.
2010: Pontus Boström; Linda Andersson; Birgitte Vind; Liliana Håversen; Mikael Rutberg; Ylva Wickström; Erik Larsson; Per-Anders Jansson; Maria K Svensson; Richard Brånemark; Charlotte Ling; Henning Beck-Nielsen; Jan Borén; Kurt Højlund; Sven-Olof Olofsson
The SNARE protein SNAP23 and the SNARE-interacting protein Munc18c in human skeletal muscle are implicated in insulin resistance/type 2 diabetes.
Diabetes 2010;59(8):1870-8.
2010: Martin Adiels; Thomas Larsson; Pauline Sutton; Marja-Riitta Taskinen; Jan Borén; Barbara A Fielding
Optimization of N-methyl-N-[tert-butyldimethylsilyl]trifluoroacetamide as a derivatization agent for determining isotopic enrichment of glycerol in very-low density lipoproteins.
Rapid communications in mass spectrometry : RCM 2010;24(5):586-92.
2010: Fei Tian; Alex-Xianghua Zhou; Anke M Smits; Erik Larsson; Marie-José Goumans; Carl-Henrik Heldin; Jan Borén; Levent M Akyürek
Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in vitro.
Biochemical and biophysical research communications 2010;392(3):283-8.
2009: Jan Borén; Martin Adiels; Ylva Wickström; Sven-Olof Olofsson; Pontus Boström
[Recruitment of medical students to research requires early engagement. A research assistant program shows that early initiation yields better results].
Läkartidningen 2009;106(46):3072-4.
2009: Pontus Boström; Linda Andersson; Lu Li; Rosie Perkins; Kurt Højlund; Jan Borén; Sven-Olof Olofsson
The assembly of lipid droplets and its relation to cellular insulin sensitivity.
Biochemical Society transactions 2009;37(Pt 5):981-5.
2009: Sara Sjöberg; Einar E Eriksson; Asa Tivesten; Annelie Carlsson; Anna Klasson; Max Levin; Jan Borén; Alexandra Krettek
CD44-deficiency on hematopoietic cells limits T-cell number but does not protect against atherogenesis in LDL receptor-deficient mice.
Atherosclerosis 2009;206(2):369-74.
2009: Marcus Ståhlman; Christer S Ejsing; Kirill Tarasov; Jeanna Perman; Jan Borén; Kim Ekroos
High-throughput shotgun lipidomics by quadrupole time-of-flight mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(26):2664-72.
2009: Fei Tian; Xianghua Zhou; Johannes Wikström; Helen Karlsson; Helén Sjöland; Li-ming Gan; Jan Borén; Levent M Akyürek
Protein disulfide isomerase increases in myocardial endothelial cells in mice exposed to chronic hypoxia: a stimulatory role in angiogenesis.
American journal of physiology. Heart and circulatory physiology 2009;297(3):H1078-86.
2009: Anne Hiukka; Marcus Ståhlman; Camilla Pettersson; Malin Levin; Martin Adiels; Susanne Teneberg; Eeva Leinonen; Lillemor Mattsson Hultén; Olov Wiklund; Matej Oresic; Sven-Olof Olofsson; Marja-Riitta Taskinen; Kim Ekroos; Jan Borén
ApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition, increased susceptibility for sphingomyelinase, and increased binding to biglycan.
Diabetes 2009;58(9):2018-26.
2009: Sven-Olof Olofsson; Pontus Boström; Linda Andersson; Mikael Rutberg; Jeanna Perman; Jan Borén
Lipid droplets as dynamic organelles connecting storage and efflux of lipids.
Biochimica et biophysica acta 2009;1791(6):448-58.
2008: Sven-Olof Olofsson; Pontus Boström; Linda Andersson; Mikael Rutberg; Malin Levin; Jeanna Perman; Jan Borén
Triglyceride containing lipid droplets and lipid droplet-associated proteins.
Current opinion in lipidology 2008;19(5):441-7.
2008: Martin Adiels; Sven-Olof Olofsson; Marja-Riitta Taskinen; Jan Borén
Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(7):1225-36.
2008: Anna Benrick; Pernilla Jirholt; Ingrid Wernstedt; Maria Gustafsson; Jürgen Scheller; Anna-Lena Eriksson; Jan Borén; Thomas Hedner; Claes Ohlsson; Torleif Härd; Stefan Rose-John; John-Olov Jansson
A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population.
Regulatory peptides 2008;146(1-3):189-96.
2008: Martin Adiels; Marja-Riitta Taskinen; Jan Borén
Fatty liver, insulin resistance, and dyslipidemia.
Current diabetes reports 2008;8(1):60-4.
2008: Marcus Ståhlman; Pia Davidsson; Ida Kanmert; Birgitta Rosengren; Jan Borén; Björn Fagerberg; Germán Camejo
Proteomics and lipids of lipoproteins isolated at low salt concentrations in D2O/sucrose or in KBr.
Journal of lipid research 2008;49(2):481-90.
2007: Pontus Boström; Linda Andersson; Mikael Rutberg; Jeanna Perman; Ulf Lidberg; Bengt R Johansson; Julia Fernandez-Rodriguez; Johanna Ericson; Tommy Nilsson; Jan Borén; Sven-Olof Olofsson
SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity.
Nature cell biology 2007;9(11):1286-93.
2007: Martin Adiels; Jukka Westerbacka; Aino Soro-Paavonen; Anna-Maija Häkkinen; Satu Vehkavaara; Muriel J Caslake; Chris Packard; Sven-Olof Olofsson; Hannele Yki-Järvinen; Marja-Riitta Taskinen; Jan Borén
Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance.
Diabetologia 2007;50(11):2356-65.
2007: Maria Gustafsson; Malin Levin; Kristina Skålén; Jeanna Perman; Vincent Fridén; Pernilla Jirholt; Sven-Olof Olofsson; Sergio Fazio; MacRae F Linton; Clay F Semenkovich; Gunilla Olivecrona; Jan Borén
Retention of low-density lipoprotein in atherosclerotic lesions of the mouse: evidence for a role of lipoprotein lipase.
Circulation research 2007;101(8):777-83.
2007: Xianghua Zhou; Jan Borén; Levent M Akyürek
Filamins in cardiovascular development.
Trends in cardiovascular medicine 2007;17(7):222-9.
2007: Johan Bourghardt; Göran Bergström; Alexandra Krettek; Sara Sjöberg; Jan Borén; Asa Tivesten
The endogenous estradiol metabolite 2-methoxyestradiol reduces atherosclerotic lesion formation in female apolipoprotein E-deficient mice.
Endocrinology 2007;148(9):4128-32.
2007: Pontus Boström; Sven-Olof Olofsson; Jan Borén; Olle G P Isaksson
[A research assistant program in Gothenburg refutes the myth about medical students' lack of interest in research].
Läkartidningen 2007;104(20-21):1627.
2007: Xianghua Zhou; Fei Tian; Johan Sandzén; Renhai Cao; Emilie Flaberg; Laszlo Szekely; Yihai Cao; Claes Ohlsson; Martin O Bergo; Jan Borén; Levent M Akyürek
Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3919-24.
2007: Daniel A Hägg; Sara Sjöberg; Lillemor Mattsson Hultén; Björn Fagerberg; Olov Wiklund; Annika Rosengren; Lena Carlsson; Jan Borén; Per-Arne Svensson; Alexandra Krettek
Augmented levels of CD44 in macrophages from atherosclerotic subjects: a possible IL-6-CD44 feedback loop?
Atherosclerosis 2007;190(2):291-7.
2007: Sven-Olof Olofsson; Olov Wiklund; Jan Borén
Apolipoproteins A-I and B: biosynthesis, role in the development of atherosclerosis and targets for intervention against cardiovascular disease.
Vascular health and risk management 2007;3(4):491-502.
2006: Olli Leppänen; Tom Björnheden; Margareta Evaldsson; Jan Borén; Olov Wiklund; Max Levin
ATP depletion in macrophages in the core of advanced rabbit atherosclerotic plaques in vivo.
Atherosclerosis 2006;188(2):323-30.
2006: Pontus Boström; björn magnusson; Per-Arne Svensson; Olov Wiklund; Jan Borén; Lena Carlsson; Marcus Ståhlman; Sven-Olof Olofsson; Lillemor Mattsson Hultén
Hypoxia converts human macrophages into triglyceride-loaded foam cells.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(8):1871-6.
2006: björn magnusson; Lennart Asp; Pontus Boström; Michel Ruiz; Pia Stillemark-Billton; Daniel Lindén; Jan Borén; Sven-Olof Olofsson
Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very low-density lipoproteins.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(7):1566-71.
2006: Linda Andersson; Pontus Boström; Johanna Ericson; Mikael Rutberg; björn magnusson; Denis Marchesan; Michel Ruiz; Lennart Asp; Ping Huang; Michael A Frohman; Jan Borén; Sven-Olof Olofsson
PLD1 and ERK2 regulate cytosolic lipid droplet formation.
Journal of cell science 2006;119(Pt 11):2246-57.
2006: Martin Adiels; Sven-Olof Olofsson; Marja-Riitta Taskinen; Jan Borén
Diabetic dyslipidaemia.
Current opinion in lipidology 2006;17(3):238-46.
2006: Martin Adiels; Marja-Riitta Taskinen; Chris Packard; Muriel J Caslake; Aino Soro-Paavonen; Jukka Westerbacka; Satu Vehkavaara; A Häkkinen; Sven-Olof Olofsson; Hannele Yki-Järvinen; Jan Borén
Overproduction of large VLDL particles is driven by increased liver fat content in man.
Diabetologia 2006;49(4):755-65.
2006: Max Levin; Donald C McCurnin; Steven R Seidner; Bradley Yoder; Nahid Waleh; Seth Goldbarg; Christine Roman; Bao Mei Liu; Jan Borén; Ronald I Clyman
Postnatal constriction, ATP depletion, and cell death in the mature and immature ductus arteriosus.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;290(2):R359-64.
2006: Irene Andersson; Maria E Johansson; Anna Wickman; Mohammad Bohlooly-Y; Natalia Klintland; Kenneth Caidahl; Maria Gustafsson; Jan Borén; Li-ming Gan; Göran Bergström
Endothelial dysfunction in growth hormone transgenic mice.
Clinical science (London, England : 1979) 2006;110(2):217-25.
2006: Lu Li; Pia Stillemark-Billton; Caroline Beck; Pontus Boström; Linda Andersson; Mikael Rutberg; Johanna Ericsson; björn magnusson; Denis Marchesan; Anna Ljungberg; Jan Borén; Sven-Olof Olofsson
Epigallocatechin gallate increases the formation of cytosolic lipid droplets and decreases the secretion of apoB-100 VLDL.
Journal of lipid research 2006;47(1):67-77.
2005: Linda Persson; Jan Borén; A Nicoletti; Göran K Hansson; Marcela Pekna
Immunoglobulin treatment reduces atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice via the complement system.
Clinical and experimental immunology 2005;142(3):441-5.
2005: Pontus Boström; Mikael Rutberg; Johanna Ericsson; Peter Holmdahl; Linda Andersson; Michael A Frohman; Jan Borén; Sven-Olof Olofsson
Cytosolic lipid droplets increase in size by microtubule-dependent complex formation.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(9):1945-51.
2005: Martin Adiels; Jan Borén; Muriel J Caslake; Philip Stewart; Aino Soro; Jukka Westerbacka; Bernt Wennberg; Sven-Olof Olofsson; Chris Packard; Marja-Riitta Taskinen
Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(8):1697-703.
2005: Max Levin; Seth Goldbarg; Anders Lindqvist; Karl Swärd; Christine Roman; Bao Mei Liu; Lillemor Mattsson Hultén; Jan Borén; Ronald I Clyman
ATP depletion and cell death in the neonatal lamb ductus arteriosus.
Pediatric research 2005;57(6):801-5.
2005: Lennart Asp; björn magnusson; Mikael Rutberg; Lu Li; Jan Borén; Sven-Olof Olofsson
Role of ADP ribosylation factor 1 in the assembly and secretion of ApoB-100-containing lipoproteins.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(3):566-70.
2005: Pia Stillemark-Billton; Caroline Beck; Jan Borén; Sven-Olof Olofsson
Relation of the size and intracellular sorting of apoB to the formation of VLDL 1 and VLDL 2.
Journal of lipid research 2005;46(1):104-14.
2005: Martin Adiels; Chris Packard; Muriel J Caslake; Philip Stewart; Aino Soro; Jukka Westerbacka; Bernt Wennberg; Sven-Olof Olofsson; Marja-Riitta Taskinen; Jan Borén
A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions.
Journal of lipid research 2005;46(1):58-67.
2004: Caroline Beck; Hidetaka Uramoto; Jan Borén; Levent M Akyürek
Tissue-specific targeting for cardiovascular gene transfer. Potential vectors and future challenges.
Current gene therapy 2004;4(4):457-67.
2004: Maria Gustafsson; Jan Borén
Mechanism of lipoprotein retention by the extracellular matrix.
Current opinion in lipidology 2004;15(5):505-14.
2004: Pernilla Jirholt; Martin Adiels; Jan Borén
How does mutant proprotein convertase neural apoptosis-regulated convertase 1 induce autosomal dominant hypercholesterolemia?
Arteriosclerosis, thrombosis, and vascular biology 2004;24(8):1334-6.
2004: Linda Persson; Jan Borén; Anna-Karin L Robertson; Ville Wallenius; Göran K Hansson; Marcela Pekna
Lack of complement factor C3, but not factor B, increases hyperlipidemia and atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(6):1062-7.
2004: Christofer Flood; Maria Gustafsson; Robert E Pitas; Lorenzo Arnaboldi; Rosemary Walzem; Jan Borén
Molecular mechanism for changes in proteoglycan binding on compositional changes of the core and the surface of low-density lipoprotein-containing human apolipoprotein B100.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(3):564-70.
2004: Maria Gustafsson; Christofer Flood; Pernilla Jirholt; Jan Borén
Retention of atherogenic lipoproteins in atherogenesis.
Cellular and molecular life sciences : CMLS 2004;61(1):4-9.
2003: Denis Marchesan; Mikael Rutberg; Linda Andersson; Lennart Asp; Thomas Larsson; Jan Borén; Bengt R Johansson; Sven-Olof Olofsson
A phospholipase D-dependent process forms lipid droplets containing caveolin, adipocyte differentiation-related protein, and vimentin in a cell-free system.
The Journal of biological chemistry 2003;278(29):27293-300.
2002: Christofer Flood; Maria Gustafsson; Paul E Richardson; Stephen C Harvey; Jere P Segrest; Jan Borén
Identification of the proteoglycan binding site in apolipoprotein B48.
The Journal of biological chemistry 2002;277(35):32228-33.
2002: Daniel Lindén; Karin Lindberg; Jan Oscarsson; Catharina Claesson; Lennart Asp; Lu Li; Maria Gustafsson; Jan Borén; Sven-Olof Olofsson
Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48.
The Journal of biological chemistry 2002;277(25):23044-53.
2002: Kristina Skålén; Maria Gustafsson; Ellen Knutsen Rydberg; Lillemor Mattsson Hultén; Olov Wiklund; Thomas L Innerarity; Jan Borén
Subendothelial retention of atherogenic lipoproteins in early atherosclerosis.
Nature 2002;417(6890):750-4.
2002: Magnus S C Johnson; Per-Arne Svensson; Jan Borén; Hakan Billig; Lena Carlsson; Björn Carlsson
Expression of scavenger receptor class B type I in gallbladder columnar epithelium.
Journal of gastroenterology and hepatology 2002;17(6):713-20.
2001: Jan Borén; Ulf Ekström; Bo Agren; Peter Nilsson-Ehle; Thomas L Innerarity
The molecular mechanism for the genetic disorder familial defective apolipoprotein B100.
The Journal of biological chemistry 2001;276(12):9214-8.
2000: Jan Borén; Maria Gustafsson; Kristina Skålén; Christofer Flood; Thomas L Innerarity
Role of extracellular retention of low density lipoproteins in atherosclerosis.
Current opinion in lipidology 2000;11(5):451-6.
2000: P Stillemark; Jan Borén; Mats X Andersson; Thomas Larsson; S Rustaeus; Karl-Anders Karlsson; Sven-Olof Olofsson
The assembly and secretion of apolipoprotein B-48-containing very low density lipoproteins in McA-RH7777 cells.
The Journal of biological chemistry 2000;275(14):10506-13.
1999: Sven-Olof Olofsson; Lennart Asp; Jan Borén
The assembly and secretion of apolipoprotein B-containing lipoproteins.
Current opinion in lipidology 1999;10(4):341-6.
1999: Murielle Véniant; Lars B Nielsen; Jan Borén; Stephen G Young
Lipoproteins containing apolipoprotein B-100 are secreted by the heart.
Trends in cardiovascular medicine 1999;9(3-4):103-7.
1999: S Rustaeus; Karin Lindberg; P Stillemark; Catharina Claesson; Lennart Asp; Thomas Larsson; Jan Borén; Sven-Olof Olofsson
Assembly of very low density lipoprotein: a two-step process of apolipoprotein B core lipidation.
The Journal of nutrition 1999;129(2S Suppl):463S-466S.
1999: Murielle Véniant; Edward Kim; S McCormick; Jan Borén; Lars B Nielsen; M Raabe; Stephen G Young
Insights into apolipoprotein B biology from transgenic and gene-targeted mice.
The Journal of nutrition 1999;129(2S Suppl):451S-455S.
1998: Lars B Nielsen; Murielle Véniant; Jan Borén; M Raabe; Jinny S Wong; Carmen Tam-Amersdorfer; LM Flynn; TM Vanni-Reyes; MD Gunn; I J Goldberg; Robert L Hamilton; Stephen G Young
Genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: evidence that the heart has the capacity to synthesize and secrete lipoproteins.
Circulation 1998;98(1):13-6.
1998: Jan Borén; Katherine L Olin; I Lee; Alan Chait; T N Wight; Thomas L Innerarity
Identification of the principal proteoglycan-binding site in LDL. A single-point mutation in apo-B100 severely affects proteoglycan interaction without affecting LDL receptor binding.
The Journal of clinical investigation 1998;101(12):2658-64.
1998: Xiaobing Qian; Maureen E Balestra; S Yamanaka; Jan Borén; I Lee; Thomas L Innerarity
Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(6):1013-20.
1998: Jan Borén; Murielle Véniant; Stephen G Young
Apo B100-containing lipoproteins are secreted by the heart.
The Journal of clinical investigation 1998;101(6):1197-202.
1998: Jere P Segrest; Martin K Jones; Vinod K Mishra; V Pierotti; S H Young; Jan Borén; Thomas L Innerarity; Nassrin Dashti
Apolipoprotein B-100: conservation of lipid-associating amphipathic secondary structural motifs in nine species of vertebrates.
Journal of lipid research 1998;39(1):85-102.
1996: David A Gordon; Haris Jamil; R E Gregg; Sven-Olof Olofsson; Jan Borén
Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step.
The Journal of biological chemistry 1996;271(51):33047-53.
1996: Jan Borén; I Lee; M J Callow; Edward M Rubin; Thomas L Innerarity
A simple and efficient method for making site-directed mutants, deletions, and fusions of large DNA such as P1 and BAC clones.
Genome research 1996;6(11):1123-30.
1996: Sally P A McCormick; J K Ng; Murielle Véniant; Jan Borén; V Pierotti; L M Flynn; D S Grass; Stephen G Young
Transgenic mice that overexpress mouse apolipoprotein B. Evidence that the DNA sequences controlling intestinal expression of the apolipoprotein B gene are distant from the structural gene.
The Journal of biological chemistry 1996;271(20):11963-70.
1996: Thomas L Innerarity; Jan Borén; S Yamanaka; Sven-Olof Olofsson
Biosynthesis of apolipoprotein B48-containing lipoproteins. Regulation by novel post-transcriptional mechanisms.
The Journal of biological chemistry 1996;271(5):2353-6.
1996: A Sjöberg; Jan Oscarsson; Jan Borén; Staffan Edén; Sven-Olof Olofsson
Mode of growth hormone administration influences triacylglycerol synthesis and assembly of apolipoprotein B-containing lipoproteins in cultured rat hepatocytes.
Journal of lipid research 1996;37(2):275-89.
1995: S Rustaeus; K Lindberg; Jan Borén; Sven-Olof Olofsson
Brefeldin A reversibly inhibits the assembly of apoB containing lipoproteins in McA-RH7777 cells.
The Journal of biological chemistry 1995;270(48):28879-86.
1994: Jan Borén; S Rustaeus; Sven-Olof Olofsson
Studies on the assembly of apolipoprotein B-100- and B-48-containing very low density lipoproteins in McA-RH7777 cells.
The Journal of biological chemistry 1994;269(41):25879-88.
1994: M Andersson; M Wettesten; Jan Borén; A Magnusson; A Sjöberg; S Rustaeus; Sven-Olof Olofsson
Purification of diacylglycerol:acyltransferase from rat liver to near homogeneity.
Journal of lipid research 1994;35(3):535-45.
1993: Jan Borén; S Rustaeus; M Wettesten; M Andersson; A Wiklund; Sven-Olof Olofsson
Influence of triacylglycerol biosynthesis rate on the assembly of apoB-100-containing lipoproteins in Hep G2 cells.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(12):1743-54.
1993: Jan Borén; M Wettesten; S Rustaeus; M Andersson; Sven-Olof Olofsson
The assembly and secretion of apoB-100-containing lipoproteins.
Biochemical Society transactions 1993;21(2):487-93.
1992: Jan Borén; L Graham; M Wettesten; J Scott; A White; Sven-Olof Olofsson
The assembly and secretion of ApoB 100-containing lipoproteins in Hep G2 cells. ApoB 100 is cotranslationally integrated into lipoproteins.
The Journal of biological chemistry 1992;267(14):9858-67.
1991: Jan Borén; A White; M Wettesten; J Scott; L Graham; Sven-Olof Olofsson
The molecular mechanism for the assembly and secretion of ApoB-100-containing lipoproteins.
Progress in lipid research 1991;30(2-3):205-18.
1990: Jan Borén; M Wettesten; A Sjöberg; Thorleif Thorlin; Göran Bondjers; Olov Wiklund; Sven-Olof Olofsson
The assembly and secretion of apoB 100 containing lipoproteins in Hep G2 cells. Evidence for different sites for protein synthesis and lipoprotein assembly.
The Journal of biological chemistry 1990;265(18):10556-64.
1988: K Boström; Jan Borén; M Wettesten; A Sjöberg; Göran Bondjers; Olov Wiklund; Peter Carlsson; Sven-Olof Olofsson
Studies on the assembly of apo B-100-containing lipoproteins in HepG2 cells.
The Journal of biological chemistry 1988;263(9):4434-42.
1987: S O Olofsson; K Boström; P Carlsson; Jan Borén; M Wettesten; Gunnar Bjursell; O Wiklund; Göran Bondjers
Structure and biosynthesis of apolipoprotein B.
American heart journal 1987;113(2 Pt 2):446-52.
1986: K Boström; M Wettesten; Jan Borén; Göran Bondjers; Olov Wiklund; Sven-Olof Olofsson
Pulse-chase studies of the synthesis and intracellular transport of apolipoprotein B-100 in Hep G2 cells.
The Journal of biological chemistry 1986;261(29):13800-6.
1985: M Wettesten; K Boström; Göran Bondjers; M Jarfeldt; P I Norfeldt; M Carrella; Olov Wiklund; Jan Borén; Sven-Olof Olofsson
Pulse-chase studies of the synthesis of apolipoprotein B in a human hepatoma cell line, Hep G2.
European journal of biochemistry / FEBS 1985;149(3):461-6.