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Jan Borén

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Boström Pontus; Andersson Linda; Li Lu; Perkins Rosie; Højlund Kurt; Borén Jan; Olofsson Sven-Olof
The assembly of lipid droplets and its relation to cellular insulin sensitivity.
Sjöberg Sara; Eriksson Einar E; Tivesten Asa; Carlsson Annelie; Klasson Anna; Levin Max; Borén Jan; Krettek Alexandra
CD44-deficiency on hematopoietic cells limits T-cell number but does not protect against atherogenesis in LDL receptor-deficient mice.
Tian Fei; Zhou Xianghua; Wikström Johannes; Karlsson Helen; Sjöland Helén; Gan Li-Ming; Borén Jan; Akyürek Levent M
Protein disulfide isomerase increases in myocardial endothelial cells in mice exposed to chronic hypoxia: a stimulatory role in angiogenesis.

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All Publications

2009: Boström Pontus; Andersson Linda; Li Lu; Perkins Rosie; Højlund Kurt; Borén Jan; Olofsson Sven-Olof
The assembly of lipid droplets and its relation to cellular insulin sensitivity.
Biochemical Society transactions 2009;37(Pt 5):981-5.
2009: Sjöberg Sara; Eriksson Einar E; Tivesten Asa; Carlsson Annelie; Klasson Anna; Levin Max; Borén Jan; Krettek Alexandra
CD44-deficiency on hematopoietic cells limits T-cell number but does not protect against atherogenesis in LDL receptor-deficient mice.
Atherosclerosis 2009;206(2):369-74.
2009: Tian Fei; Zhou Xianghua; Wikström Johannes; Karlsson Helen; Sjöland Helén; Gan Li-Ming; Borén Jan; Akyürek Levent M
Protein disulfide isomerase increases in myocardial endothelial cells in mice exposed to chronic hypoxia: a stimulatory role in angiogenesis.
American journal of physiology. Heart and circulatory physiology 2009;297(3):H1078-86.
2009: Hiukka Anne; Ståhlman Marcus; Pettersson Camilla; Levin Malin; Adiels Martin; Teneberg Susanne; Leinonen Eeva S; Hultén Lillemor Mattsson; Wiklund Olov; Oresic Matej; Olofsson Sven-Olof; Taskinen Marja-Riitta; Ekroos Kim; Borén Jan
ApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition, increased susceptibility for sphingomyelinase, and increased binding to biglycan.
Diabetes 2009;58(9):2018-26.
2009: Ståhlman Marcus; Ejsing Christer S; Tarasov Kirill; Perman Jeanna; Borén Jan; Ekroos Kim
High-throughput shotgun lipidomics by quadrupole time-of-flight mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(26):2664-72.
2009: Olofsson Sven-Olof; Boström Pontus; Andersson Linda; Rutberg Mikael; Perman Jeanna; Borén Jan
Lipid droplets as dynamic organelles connecting storage and efflux of lipids.
Biochimica et biophysica acta 2009;1791(6):448-58.
2008: Olofsson Sven-Olof; Boström Pontus; Andersson Linda; Rutberg Mikael; Levin Malin; Perman Jeanna; Borén Jan
Triglyceride containing lipid droplets and lipid droplet-associated proteins.
Current opinion in lipidology 2008;19(5):441-7.
2008: Adiels Martin; Olofsson Sven-Olof; Taskinen Marja-Riitta; Borén Jan
Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(7):1225-36.
2008: Adiels Martin; Taskinen Marja-Riitta; Borén Jan
Fatty liver, insulin resistance, and dyslipidemia.
Current diabetes reports 2008;8(1):60-4.
2008: Ståhlman Marcus; Davidsson Pia; Kanmert Ida; Rosengren Birgitta; Borén Jan; Fagerberg Björn; Camejo Germán
Proteomics and lipids of lipoproteins isolated at low salt concentrations in D2O/sucrose or in KBr.
Journal of lipid research 2008;49(2):481-90.
2008: Benrick Anna; Jirholt Pernilla; Wernstedt Ingrid; Gustafsson Maria; Scheller Juergen; Eriksson Anna-Lena; Borén Jan; Hedner Thomas; Ohlsson Claes; Härd Torleif; Rose-John Stefan; Jansson John-Olov
A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population.
Regulatory peptides 2008;146(1-3):189-96.
2007: Boström Pontus; Andersson Linda; Rutberg Mikael; Perman Jeanna; Lidberg Ulf; Johansson Bengt R; Fernandez-Rodriguez Julia; Ericson Johanna; Nilsson Tommy; Borén Jan; Olofsson Sven-Olof
SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity.
Nature cell biology 2007;9(11):1286-93.
2007: Adiels M; Westerbacka J; Soro-Paavonen A; Häkkinen A M; Vehkavaara S; Caslake M J; Packard C; Olofsson S O; Yki-Järvinen H; Taskinen M R; Borén J
Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance.
Diabetologia 2007;50(11):2356-65.
2007: Zhou Xianghua; Borén Jan; Akyürek Levent M
Filamins in cardiovascular development.
Trends in cardiovascular medicine 2007;17(7):222-9.
2007: Gustafsson Maria; Levin Malin; Skålén Kristina; Perman Jeanna; Fridén Vincent; Jirholt Pernilla; Olofsson Sven-Olof; Fazio Sergio; Linton MacRae F; Semenkovich Clay F; Olivecrona Gunilla; Borén Jan
Retention of low-density lipoprotein in atherosclerotic lesions of the mouse: evidence for a role of lipoprotein lipase.
Circulation research 2007;101(8):777-83.
2007: Bourghardt Johan; Bergström Göran; Krettek Alexandra; Sjöberg Sara; Borén Jan; Tivesten Asa
The endogenous estradiol metabolite 2-methoxyestradiol reduces atherosclerotic lesion formation in female apolipoprotein E-deficient mice.
Endocrinology 2007;148(9):4128-32.
2007: Boström Pontus; Olofsson Sven-Olof; Borén Jan; Isaksson Olle
[A research assistant program in Gothenburg refutes the myth about medical students' lack of interest in research]
Läkartidningen 2007;104(20-21):1627.
2007: Zhou Xianghua; Tian Fei; Sandzén Johan; Cao Renhai; Flaberg Emilie; Szekely Laszlo; Cao Yihai; Ohlsson Claes; Bergo Martin O; Borén Jan; Akyürek Levent M
Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3919-24.
2007: Hägg Daniel; Sjöberg Sara; Hultén Lillemor Mattsson; Fagerberg Björn; Wiklund Olov; Rosengren Annika; Carlsson Lena M S; Borén Jan; Svensson Per-Arne; Krettek Alexandra
Augmented levels of CD44 in macrophages from atherosclerotic subjects: a possible IL-6-CD44 feedback loop?
Atherosclerosis 2007;190(2):291-7.
2007: Olofsson Sven-Olof; Wiklund Olov; Borén Jan
Apolipoproteins A-I and B: biosynthesis, role in the development of atherosclerosis and targets for intervention against cardiovascular disease.
Vascular health and risk management 2007;3(4):491-502.
2006: Leppänen Olli; Björnheden Tom; Evaldsson Margareta; Borén Jan; Wiklund Olov; Levin Max
ATP depletion in macrophages in the core of advanced rabbit atherosclerotic plaques in vivo.
Atherosclerosis 2006;188(2):323-30.
2006: Boström Pontus; Magnusson Björn; Svensson Per-Arne; Wiklund Olov; Borén Jan; Carlsson Lena M S; Ståhlman Marcus; Olofsson Sven-Olof; Hultén Lillemor Mattsson
Hypoxia converts human macrophages into triglyceride-loaded foam cells.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(8):1871-6.
2006: Magnusson Björn; Asp Lennart; Boström Pontus; Ruiz Michel; Stillemark-Billton Pia; Lindén Daniel; Borén Jan; Olofsson Sven-Olof
Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very low-density lipoproteins.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(7):1566-71.
2006: Andersson Linda; Boström Pontus; Ericson Johanna; Rutberg Mikael; Magnusson Björn; Marchesan Denis; Ruiz Michel; Asp Lennart; Huang Ping; Frohman Michael A; Borén Jan; Olofsson Sven-Olof
PLD1 and ERK2 regulate cytosolic lipid droplet formation.
Journal of cell science 2006;119(Pt 11):2246-57.
2006: Adiels Martin; Olofsson Sven-Olof; Taskinen Marja-Riitta; Borén Jan
Diabetic dyslipidaemia.
Current opinion in lipidology 2006;17(3):238-46.
2006: Adiels M; Taskinen M-R; Packard C; Caslake M J; Soro-Paavonen A; Westerbacka J; Vehkavaara S; Häkkinen A; Olofsson S-O; Yki-Järvinen H; Borén J
Overproduction of large VLDL particles is driven by increased liver fat content in man.
Diabetologia 2006;49(4):755-65.
2006: Levin Max; McCurnin Don; Seidner Steven R; Yoder Bradley; Waleh Nahid; Goldbarg Seth; Roman Christine; Liu Bao Mei; Borén Jan; Clyman Ronald I
Postnatal constriction, ATP depletion, and cell death in the mature and immature ductus arteriosus.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;290(2):R359-64.
2006: Andersson Irene J; Johansson Maria E; Wickman Anna; Bohlooly-Y Mohammad; Klintland Natalia; Caidahl Kenneth; Gustafsson Maria; Borén Jan; Gan Li-ming; Bergström Göran
Endothelial dysfunction in growth hormone transgenic mice.
Clinical science (London, England : 1979) 2006;110(2):217-25.
2006: Li Lu; Stillemark-Billton Pia; Beck Caroline; Boström Pontus; Andersson Linda; Rutberg Mikael; Ericsson Johanna; Magnusson Björn; Marchesan Denis; Ljungberg Anna; Borén Jan; Olofsson Sven-Olof
Epigallocatechin gallate increases the formation of cytosolic lipid droplets and decreases the secretion of apoB-100 VLDL.
Journal of lipid research 2006;47(1):67-77.
2005: Persson L; Borén J; Nicoletti A; Hansson G K; Pekna M
Immunoglobulin treatment reduces atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice via the complement system.
Clinical and experimental immunology 2005;142(3):441-5.
2005: Boström Pontus; Rutberg Mikael; Ericsson Johanna; Holmdahl Peter; Andersson Linda; Frohman Michael A; Borén Jan; Olofsson Sven-Olof
Cytosolic lipid droplets increase in size by microtubule-dependent complex formation.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(9):1945-51.
2005: Adiels Martin; Borén Jan; Caslake Muriel J; Stewart Philip; Soro Aino; Westerbacka Jukka; Wennberg Bernt; Olofsson Sven-Olof; Packard Chris; Taskinen Marja-Riitta
Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(8):1697-703.
2005: Levin Max; Goldbarg Seth; Lindqvist Anders; Swärd Karl; Roman Christine; Liu Bao Mei; Hultén Lillemor Mattsson; Borén Jan; Clyman Ronald I
ATP depletion and cell death in the neonatal lamb ductus arteriosus.
Pediatric research 2005;57(6):801-5.
2005: Asp Lennart; Magnusson Björn; Rutberg Mikael; Li Lu; Borén Jan; Olofsson Sven-Olof
Role of ADP ribosylation factor 1 in the assembly and secretion of ApoB-100-containing lipoproteins.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(3):566-70.
2005: Stillemark-Billton Pia; Beck Caroline; Borén Jan; Olofsson Sven-Olof
Relation of the size and intracellular sorting of apoB to the formation of VLDL 1 and VLDL 2.
Journal of lipid research 2005;46(1):104-14.
2005: Adiels Martin; Packard Chris; Caslake Muriel J; Stewart Philip; Soro Aino; Westerbacka Jukka; Wennberg Bernt; Olofsson Sven-Olof; Taskinen Marja-Riitta; Borén Jan
A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions.
Journal of lipid research 2005;46(1):58-67.
2004: Beck Caroline; Uramoto Hidetaka; Borén Jan; Akyürek Levent M
Tissue-specific targeting for cardiovascular gene transfer. Potential vectors and future challenges.
Current gene therapy 2004;4(4):457-67.
2004: Gustafsson Maria; Borén Jan
Mechanism of lipoprotein retention by the extracellular matrix.
Current opinion in lipidology 2004;15(5):505-14.
2004: Jirholt Pernilla; Adiels Martin; Borén Jan
How does mutant proprotein convertase neural apoptosis-regulated convertase 1 induce autosomal dominant hypercholesterolemia?
Arteriosclerosis, thrombosis, and vascular biology 2004;24(8):1334-6.
2004: Persson Linda; Borén Jan; Robertson Anna-Karin L; Wallenius Ville; Hansson Göran K; Pekna Marcela
Lack of complement factor C3, but not factor B, increases hyperlipidemia and atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(6):1062-7.
2004: Flood Christofer; Gustafsson Maria; Pitas Robert E; Arnaboldi Lorenzo; Walzem Rosemary L; Borén Jan
Molecular mechanism for changes in proteoglycan binding on compositional changes of the core and the surface of low-density lipoprotein-containing human apolipoprotein B100.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(3):564-70.
2004: Gustafsson M; Flood C; Jirholt P; Borén J
Retention of atherogenic lipoproteins in atherogenesis.
Cellular and molecular life sciences : CMLS 2004;61(1):4-9.
2003: Marchesan Denis; Rutberg Mikael; Andersson Linda; Asp Lennart; Larsson Thomas; Borén Jan; Johansson Bengt R; Olofsson Sven-Olof
A phospholipase D-dependent process forms lipid droplets containing caveolin, adipocyte differentiation-related protein, and vimentin in a cell-free system.
The Journal of biological chemistry 2003;278(29):27293-300.
2002: Flood Christofer; Gustafsson Maria; Richardson Paul E; Harvey Stephen C; Segrest Jere P; Borén Jan
Identification of the proteoglycan binding site in apolipoprotein B48.
The Journal of biological chemistry 2002;277(35):32228-33.
2002: Johnson Magnus S C; Svensson Per-Arne; Borén Jan; Billig Håkan; Carlsson Lena M S; Carlsson Björn
Expression of scavenger receptor class B type I in gallbladder columnar epithelium.
Journal of gastroenterology and hepatology 2002;17(6):713-20.
2002: Skålén Kristina; Gustafsson Maria; Rydberg Ellen Knutsen; Hultén Lillemor Mattsson; Wiklund Olov; Innerarity Thomas L; Borén Jan
Subendothelial retention of atherogenic lipoproteins in early atherosclerosis.
Nature 2002;417(6890):750-4.
2002: Lindén Daniel; Lindberg Karin; Oscarsson Jan; Claesson Catharina; Asp Lennart; Li Lu; Gustafsson Maria; Borén Jan; Olofsson Sven-Olof
Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48.
The Journal of biological chemistry 2002;277(25):23044-53.
2001: Borén J; Ekström U; Agren B; Nilsson-Ehle P; Innerarity T L
The molecular mechanism for the genetic disorder familial defective apolipoprotein B100.
The Journal of biological chemistry 2001;276(12):9214-8.
2000: Borén J; Gustafsson M; Skålén K; Flood C; Innerarity T L
Role of extracellular retention of low density lipoproteins in atherosclerosis.
Current opinion in lipidology 2000;11(5):451-6.
2000: Stillemark P; Borén J; Andersson M; Larsson T; Rustaeus S; Karlsson K A; Olofsson S O
The assembly and secretion of apolipoprotein B-48-containing very low density lipoproteins in McA-RH7777 cells.
The Journal of biological chemistry 2000;275(14):10506-13.
1999: Olofsson S O; Asp L; Borén J
The assembly and secretion of apolipoprotein B-containing lipoproteins.
Current opinion in lipidology 1999;10(4):341-6.
1999: Véniant M M; Nielsen L B; Borén J; Young S G
Lipoproteins containing apolipoprotein B-100 are secreted by the heart.
Trends in cardiovascular medicine 1999;9(3-4):103-7.
1999: Rustaeus S; Lindberg K; Stillemark P; Claesson C; Asp L; Larsson T; Borén J; Olofsson S O
Assembly of very low density lipoprotein: a two-step process of apolipoprotein B core lipidation.
The Journal of nutrition 1999;129(2S Suppl):463S-466S.
1999: Véniant M M; Kim E; McCormick S; Borén J; Nielsen L B; Raabe M; Young S G
Insights into apolipoprotein B biology from transgenic and gene-targeted mice.
The Journal of nutrition 1999;129(2S Suppl):451S-455S.
1998: Nielsen L B; Véniant M; Borén J; Raabe M; Wong J S; Tam C; Flynn L; Vanni-Reyes T; Gunn M D; Goldberg I J; Hamilton R L; Young S G
Genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: evidence that the heart has the capacity to synthesize and secrete lipoproteins.
Circulation 1998;98(1):13-6.
1998: Borén J; Olin K; Lee I; Chait A; Wight T N; Innerarity T L
Identification of the principal proteoglycan-binding site in LDL. A single-point mutation in apo-B100 severely affects proteoglycan interaction without affecting LDL receptor binding.
The Journal of clinical investigation 1998;101(12):2658-64.
1998: Qian X; Balestra M E; Yamanaka S; Borén J; Lee I; Innerarity T L
Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(6):1013-20.
1998: Borén J; Véniant M M; Young S G
Apo B100-containing lipoproteins are secreted by the heart.
The Journal of clinical investigation 1998;101(6):1197-202.
1998: Segrest J P; Jones M K; Mishra V K; Pierotti V; Young S H; Borén J; Innerarity T L; Dashti N
Apolipoprotein B-100: conservation of lipid-associating amphipathic secondary structural motifs in nine species of vertebrates.
Journal of lipid research 1998;39(1):85-102.
1996: Gordon D A; Jamil H; Gregg R E; Olofsson S O; Borén J
Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step.
The Journal of biological chemistry 1996;271(51):33047-53.
1996: Borén J; Lee I; Callow M J; Rubin E M; Innerarity T L
A simple and efficient method for making site-directed mutants, deletions, and fusions of large DNA such as P1 and BAC clones.
Genome research 1996;6(11):1123-30.
1996: McCormick S P; Ng J K; Véniant M; Borén J; Pierotti V; Flynn L M; Grass D S; ConnollyA; Young S G
Transgenic mice that overexpress mouse apolipoprotein B. Evidence that the DNA sequences controlling intestinal expression of the apolipoprotein B gene are distant from the structural gene.
The Journal of biological chemistry 1996;271(20):11963-70.
1996: Sjöberg A; Oscarsson J; Borén J; Edén S; Olofsson S O
Mode of growth hormone administration influences triacylglycerol synthesis and assembly of apolipoprotein B-containing lipoproteins in cultured rat hepatocytes.
Journal of lipid research 1996;37(2):275-89.
1996: Innerarity T L; Borén J; Yamanaka S; Olofsson S O
Biosynthesis of apolipoprotein B48-containing lipoproteins. Regulation by novel post-transcriptional mechanisms.
The Journal of biological chemistry 1996;271(5):2353-6.
1995: Rustaeus S; Lindberg K; Borén J; Olofsson S O
Brefeldin A reversibly inhibits the assembly of apoB containing lipoproteins in McA-RH7777 cells.
The Journal of biological chemistry 1995;270(48):28879-86.
1994: Borén J; Rustaeus S; Olofsson S O
Studies on the assembly of apolipoprotein B-100- and B-48-containing very low density lipoproteins in McA-RH7777 cells.
The Journal of biological chemistry 1994;269(41):25879-88.
1994: Andersson M; Wettesten M; Borén J; Magnusson A; Sjöberg A; Rustaeus S; Olofsson S O
Purification of diacylglycerol:acyltransferase from rat liver to near homogeneity.
Journal of lipid research 1994;35(3):535-45.
1993: Borén J; Rustaeus S; Wettesten M; Andersson M; Wiklund A; Olofsson S O
Influence of triacylglycerol biosynthesis rate on the assembly of apoB-100-containing lipoproteins in Hep G2 cells.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(12):1743-54.
1993: Borén J; Wettesten M; Rustaeus S; Andersson M; Olofsson S O
The assembly and secretion of apoB-100-containing lipoproteins.
Biochemical Society transactions 1993;21(2):487-93.
1992: Borén J; Graham L; Wettesten M; Scott J; White A; Olofsson S O
The assembly and secretion of ApoB 100-containing lipoproteins in Hep G2 cells. ApoB 100 is cotranslationally integrated into lipoproteins.
The Journal of biological chemistry 1992;267(14):9858-67.
1991: Borén J; White A; Wettesten M; Scott J; Graham L; Olofsson S O
The molecular mechanism for the assembly and secretion of ApoB-100-containing lipoproteins.
Progress in lipid research 1991;30(2-3):205-18.
1990: Borén J; Wettesten M; Sjöberg A; Thorlin T; Bondjers G; Wiklund O; Olofsson S O
The assembly and secretion of apoB 100 containing lipoproteins in Hep G2 cells. Evidence for different sites for protein synthesis and lipoprotein assembly.
The Journal of biological chemistry 1990;265(18):10556-64.
1988: Boström K; Borén J; Wettesten M; Sjöberg A; Bondjers G; Wiklund O; Carlsson P; Olofsson S O
Studies on the assembly of apo B-100-containing lipoproteins in HepG2 cells.
The Journal of biological chemistry 1988;263(9):4434-42.
1987: Olofsson S O; Boström K; Carlsson P; Borén J; Wettesten M; Bjursell G; Wiklund O; Bondjers G
Structure and biosynthesis of apolipoprotein B.
American heart journal 1987;113(2 Pt 2):446-52.
1986: Boström K; Wettesten M; Borén J; Bondjers G; Wiklund O; Olofsson S O
Pulse-chase studies of the synthesis and intracellular transport of apolipoprotein B-100 in Hep G2 cells.
The Journal of biological chemistry 1986;261(29):13800-6.
1985: Wettesten M; Boström K; Bondjers G; Jarfeldt M; Norfeldt P I; Carrella M; Wiklund O; Borén J; Olofsson S O
Pulse-chase studies of the synthesis of apolipoprotein B in a human hepatoma cell line, Hep G2.
European journal of biochemistry / FEBS 1985;149(3):461-6.

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Jan Borén

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