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Malcolm Taylor

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Paul F Worth; Laura L Wootton; Paul M Biggs; Philip J Byrd; Ellen F Carney; Nicholas P Davies; James I Last; Anna Smith; Venkataramanan Srinivasan; A Malcolm R Taylor
Very mild presentation in adult with classical cellular phenotype of ataxia telangiectasia.
Anna Skowronska; A Malcolm R Taylor; Peter Thomas; Gulshanara Ahmed; Zadie Davis; Martin Dyer; David Gonzalez; Estella Matutes; Paul Moss; Ceri Oldreive; David Oscier; Anton Parker; Sue Richards; Tatjana Stankovic
Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial.
Maira Tankimanova; A Malcolm R Taylor; Bethan Britt-Compton; Rebecca Capper; Rhiannon E Jones; Boitelo T Letsolo; Jan Rowson; Duncan M Baird
Mre11 modulates the fidelity of fusion between short telomeres in human cells.

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2013: Paul F Worth; Laura L Wootton; Paul M Biggs; Philip J Byrd; Ellen F Carney; Nicholas P Davies; James I Last; Anna Smith; Venkataramanan Srinivasan; A Malcolm R Taylor
Very mild presentation in adult with classical cellular phenotype of ataxia telangiectasia.
Movement disorders : official journal of the Movement Disorder Society 2013;28(4):524-8.
2012: Anna Skowronska; A Malcolm R Taylor; Peter Thomas; Gulshanara Ahmed; Zadie Davis; Martin Dyer; David Gonzalez; Estella Matutes; Paul Moss; Ceri Oldreive; David Oscier; Anton Parker; Sue Richards; Tatjana Stankovic
Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(36):4524-32.
2012: Maira Tankimanova; A Malcolm R Taylor; Bethan Britt-Compton; Rebecca Capper; Rhiannon E Jones; Boitelo T Letsolo; Jan Rowson; Duncan M Baird
Mre11 modulates the fidelity of fusion between short telomeres in human cells.
Nucleic acids research 2012;40(6):2518-26.
2012: Sophie E Polo; Andre Rusch; Philippa Smith; Grant S Stewart; A Malcolm R Taylor; Anoushka Thomas; Andrew S Turnell; Julia Kzhyshkowska; Linda Baskcomb; Andrew N Blackford; Rachel Blundred; J Ross Chapman; Thomas Dobner; Roger J Grand; Serge Gravel; Stephen P Jackson
Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair.
Molecular cell 2012;45(4):505-16.
2012: Tomoo Ogi; Katrina Prescott; Grant S Stewart; Tom Stiff; Mohnish Suri; A Malcolm R Taylor; Pradeep Vasudevan; Sarah Walker; Margaret Barrow; Philip J Byrd; Gillian Carpenter; Emma Hobson; Siripan Limsirichaikul; Michiko Matsuse; Norisato Mitsutake; Yuka Nakazawa; Mark O'Driscoll; Penny A Jeggo
Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome.
PLoS genetics 2012;8(11):e1002945.
2011: James Stevens; A Malcolm R Taylor; J Gareth Llewelyn; Nicholas W Wood
Ataxia in a young patient.
Practical neurology 2011;11(5):319-22.
2011: Andrew Robert Exley; Robert Hallam; Susan Harris; Elizabeth Hodges; James Last; Nicholas Screaton; Samantha Buckenham; Philip J Byrd; A Malcolm R Taylor; Claire Trinder; Anthony P Williams; John M Shneerson
Premature ageing of the immune system underlies immunodeficiency in ataxia telangiectasia.
Clinical immunology (Orlando, Fla.) 2011;140(1):26-36.
2010: Victoria J Weston; Ceri E Oldreive; Anna Skowronska; David Oscier; Guy Pratt; Martin J S Dyer; Graeme Smith; Judith E Powell; Zbigniew Rudzki; Pamela Kearns; Paul A H Moss; A Malcolm R Taylor; Tatjana Stankovic
The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo.
Blood 2010;116(22):4578-87.
2010: Andrew N Blackford; Rakesh N Patel; Natalie A Forrester; Kathrin Theil; Peter Groitl; Grant S Stewart; A Malcolm R Taylor; Iain M Morgan; Thomas Dobner; Roger J A Grand; Andrew S Turnell
Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(27):12251-6.
2010: Edith Terrenoire; Fiona McRonald; John A Halsall; Paula Page; Robert S Illingworth; A Malcolm R Taylor; Val Davison; Laura P O'Neill; Bryan M Turner
Immunostaining of modified histones defines high-level features of the human metaphase epigenome.
Genome biology 2010;11(11):R110.
2009: Giancarlo Barone; Alix Groom; Anne Reiman; Venkataramanan Srinivasan; Philip J Byrd; A Malcolm R Taylor
Modeling ATM mutant proteins from missense changes confirms retained kinase activity.
Human mutation 2009;30(8):1222-30.
2009: Fatima Carrillo; Susanne A Schneider; A Malcolm R Taylor; Venkataramanan Srinivasan; Raj Kapoor; Kailash P Bhatia
Prominent oromandibular dystonia and pharyngeal telangiectasia in atypical ataxia telangiectasia.
Cerebellum (London, England) 2009;8(1):22-7.
2009: Grant S Stewart; Stephanie Panier; Kelly Townsend; Abdallah K Al-Hakim; Nadine K Kolas; Edward S Miller; Shinichiro Nakada; Jarkko Ylanko; Signe Olivarius; Megan Mendez; Ceri Oldreive; Jan Wildenhain; Andrea Tagliaferro; Laurence Pelletier; Nadine Taubenheim; Anne Durandy; Philip J Byrd; Tatjana Stankovic; A Malcolm R Taylor; Daniel Durocher
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.
Cell 2009;136(3):420-34.
2008: Belinda Austen; Giancarlo Barone; Anne Reiman; Philip J Byrd; Claire Baker; Jane Starczynski; Michael C Nobbs; Raymond P Murphy; Helen Enright; Elijah Chaila; John Quinn; Tatjana Stankovic; Guy Pratt; A Malcolm R Taylor
Pathogenic ATM mutations occur rarely in a subset of multiple myeloma patients.
British journal of haematology 2008;142(6):925-33.
2008: Andrew N Blackford; Rachel Bruton; Orkide Dirlik; Grant S Stewart; A Malcolm R Taylor; Thomas Dobner; Roger J A Grand; Andrew S Turnell
A role for E1B-AP5 in ATR signaling pathways during adenovirus infection.
Journal of virology 2008;82(15):7640-52.
2008: Likun Du; Deborah K Dunn-Walters; Krystyna H Chrzanowska; Tanja Stankovic; Ashwin Kotnis; Xin Li; Jiayi Lu; Gösta Eggertsen; Claire Brittain; Sergey W Popov; Andrew R Gennery; A Malcolm R Taylor; Qiang Pan-Hammarstrom
A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation.
PloS one 2008;3(6):e2482.
2007: Belinda Austen; Anna Skowronska; Claire Baker; Judith E Powell; Anne Gardiner; David Oscier; Aneela Majid; Martin Dyer; Reiner Siebert; A Malcolm R Taylor; Paul A H Moss; Tatjana Stankovic
Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(34):5448-57.
2007: S Bose; Jane Starczynski; M Chukwuma; Karl Baumforth; wenbin Wei; Susan Morgan; Philip J Byrd; J Ying; Richard G Grundy; Jillian R Mann; Q Tao; A Malcolm R Taylor; Paul G Murray; Tatjana Stankovic
Down-regulation of ATM protein in HRS cells of nodular sclerosis Hodgkin's lymphoma in children occurs in the absence of ATM gene inactivation.
The Journal of pathology 2007;213(3):329-36.
2007: Grant S Stewart; Tatjana Stankovic; Philip J Byrd; Thomas Wechsler; Edward S Miller; Aarn Huissoon; Mark T Drayson; Stephen C West; Stephen J Elledge; A Malcolm R Taylor
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):16910-5.
2007: Amanda Dutton; Ciaran B Woodman; Marilyn B Chukwuma; James I K Last; wenbin Wei; Martina Vockerodt; Karl Baumforth; Joanne R Flavell; Martin Rowe; A Malcolm R Taylor; Lawrence S Young; Paul G Murray
Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells.
Blood 2007;109(6):2597-603.
2006: Amre Shahwan; Philip J Byrd; A Malcolm R Taylor; Therese Nestor; Stephanie Ryan; Mary D King
Atypical presentation of ataxia-oculomotor apraxia type 1.
Developmental medicine and child neurology 2006;48(6):529-32.
2005: Belinda Austen; Judith E Powell; Azra J Alvi; Ian Edwards; Laura Hooper; Jane Starczynski; A Malcolm R Taylor; Christopher Fegan; Paul Moss; Tatjana Stankovic
Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL.
Blood 2005;106(9):3175-82.
2005: A Malcolm R Taylor; Philip J Byrd
Molecular pathology of ataxia telangiectasia.
Journal of clinical pathology 2005;58(10):1009-15.
2005: Jong-Soo Kim; Tatiana B Krasieva; Hitoshi Kurumizaka; David J Chen; A Malcolm R Taylor; Kyoko Yokomori
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.
The Journal of cell biology 2005;170(3):341-7.
2005: Azra J Alvi; Belinda Austen; Victoria J Weston; Christopher Fegan; David E MacCallum; Athos Gianella-Borradori; David P Lane; Mike Hubank; Judith E Powell; wenbin Wei; A Malcolm R Taylor; Paul A H Moss; Tatjana Stankovic
A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.
Blood 2005;105(11):4484-91.
2004: Paula M Clements; Claire Breslin; Emma D Deeks; Philip J Byrd; Limei Ju; Pawel Bieganowski; Charles Brenner; Maria-Céu Moreira; A Malcolm R Taylor; Keith W Caldecott
The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4.
DNA repair 2004;3(11):1493-502.
2004: Stefan Meyer; Helen Kingston; A Malcolm R Taylor; Philip J Byrd; James I K Last; Bernadette M D Brennan; Steve Trueman; Anna Kelsey; G Malcolm Taylor; Osborn B Eden
Rhabdomyosarcoma in Nijmegen breakage syndrome: strong association with perianal primary site.
Cancer genetics and cytogenetics 2004;154(2):169-74.
2004: Victoria J Weston; Belinda Austen; wenbin Wei; Eliot Marston; Azra J Alvi; Sarah Lawson; Philip J Darbyshire; Mike Griffiths; Frank Hill; Jillian R Mann; Paul A H Moss; A Malcolm R Taylor; Tatjana Stankovic
Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-kappaB survival pathway signaling.
Blood 2004;104(5):1465-73.
2004: A Malcolm R Taylor; A Groom; Philip J Byrd
Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis.
DNA repair 2004;3(8-9):1219-25.
2004: Louise Izatt; Andrea H Németh; Anjela Meesaq; Kerry R Mills; A Malcolm R Taylor; Christopher Shaw
Autosomal recessive spinocerebellar ataxia and peripheral neuropathy with raised alpha-fetoprotein.
Journal of neurology 2004;251(7):805-12.
2004: Ian J Sutton; James I K Last; Susan J Ritchie; Hugh J Harrington; Philip J Byrd; A Malcolm R Taylor
Adult-onset ataxia telangiectasia due to ATM 5762ins137 mutation homozygosity.
Annals of neurology 2004;55(6):891-5.
2004: Aleksi Lähdesmäki; A Malcolm R Taylor; Krystyna H Chrzanowska; Qiang Pan-Hammarstrom
Delineation of the role of the Mre11 complex in class switch recombination.
The Journal of biological chemistry 2004;279(16):16479-87.
2004: Tatjana Stankovic; Mike Hubank; Debbie Cronin; Grant S Stewart; Danielle Fletcher; Colin R Bignell; Azra J Alvi; Belinda Austen; Victoria J Weston; Christopher Fegan; Philip J Byrd; Paul A H Moss; A Malcolm R Taylor
Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses.
Blood 2004;103(1):291-300.
2003: Jane Starczynski; William Simmons; Joanne R Flavell; Philip J Byrd; Grant S Stewart; Harjit S Kullar; Alix Groom; John Crocker; Paul A H Moss; Gary M Reynolds; Meri Glavina-Durdov; A Malcolm R Taylor; Christopher Fegan; Tatjana Stankovic; Paul G Murray
Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias.
The American journal of pathology 2003;163(2):423-32.
2003: Grant S Stewart; Bin Wang; Colin R Bignell; A Malcolm R Taylor; Stephen J Elledge
MDC1 is a mediator of the mammalian DNA damage checkpoint.
Nature 2003;421(6926):961-6.
2002: Jong-Soo Kim; Tatiana B Krasieva; Vickie J LaMorte; A Malcolm R Taylor; Kyoko Yokomori
Specific recruitment of human cohesin to laser-induced DNA damage.
The Journal of biological chemistry 2002;277(47):45149-53.
2002: Tatjana Stankovic; Grant S Stewart; Philip J Byrd; Christopher Fegan; Paul A H Moss; A Malcolm R Taylor
ATM mutations in sporadic lymphoid tumours.
Leukemia & lymphoma 2002;43(8):1563-71.
2002: Tatjana Stankovic; Grant S Stewart; Christopher Fegan; Paul Biggs; James I K Last; Philip J Byrd; Russell D Keenan; Paul A H Moss; A Malcolm R Taylor
Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage.
Blood 2002;99(1):300-9.
2001: Victoria J Weston; Carmel M McConville; Jillian R Mann; Philip J Darbyshire; Sarah Lawson; J Gordon; Paul A H Moss; A Malcolm R Taylor; Tatjana Stankovic
Molecular analysis of single colonies reveals a diverse origin of initial clonal proliferation in B-precursor acute lymphoblastic leukemia that can precede the t(12;21) translocation.
Cancer research 2001;61(23):8547-53.
2001: A Malcolm R Taylor
Chromosome instability syndromes.
Best practice & research. Clinical haematology 2001;14(3):631-44.
2001: Grant S Stewart; James I K Last; Tatjana Stankovic; N Haites; A M Kidd; Philip J Byrd; A Malcolm R Taylor
Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T-->G mutations, showing a less severe phenotype.
The Journal of biological chemistry 2001;276(32):30133-41.
2001: S A Pitts; H S Kullar; Tatjana Stankovic; Grant S Stewart; James I K Last; T Bedenham; Susan J Armstrong; Maria Piane; Luciana Chessa; A Malcolm R Taylor; Philip J Byrd
hMRE11: genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay.
Human molecular genetics 2001;10(11):1155-62.
2000: Tatjana Stankovic; Victoria J Weston; Carmel M McConville; E Green; Judith E Powell; Jillian R Mann; Philip J Darbyshire; A Malcolm R Taylor
Clonal diversity of Ig and T-cell receptor gene rearrangements in childhood B-precursor acute lymphoblastic leukaemia.
Leukemia & lymphoma 2000;36(3-4):213-24.
1999: Grant S Stewart; richard s maser; Tatjana Stankovic; Debra A Bressan; M I Kaplan; Nicolaas G J Jaspers; Anja Raams; Philip J Byrd; John H J Petrini; A Malcolm R Taylor
The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder.
Cell 1999;99(6):577-87.
1999: Tatjana Stankovic; peter weber; G Stewart; T Bedenham; J Murray; Philip J Byrd; Paul A H Moss; A Malcolm R Taylor
Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia.
Lancet 1999;353(9146):26-9.
1998: E Green; Carmel M McConville; Judith E Powell; Jillian R Mann; Philip J Darbyshire; A Malcolm R Taylor; Tatjana Stankovic
Clonal diversity of Ig and T-cell-receptor gene rearrangements identifies a subset of childhood B-precursor acute lymphoblastic leukemia with increased risk of relapse.
Blood 1998;92(3):952-8.
1998: A Malcolm R Taylor
What has the cloning of the ATM gene told us about ataxia telangiectasia?
International journal of radiation biology 1998;73(4):365-71.
1998: Tatjana Stankovic; A M Kidd; A Sutcliffe; G M McGuire; P Robinson; peter weber; T Bedenham; Arthur R Bradwell; Douglas F Easton; G G Lennox; N Haites; Philip J Byrd; A Malcolm R Taylor
ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer.
American journal of human genetics 1998;62(2):334-45.
1997: Tatjana Stankovic; Philip J Byrd; Paul Roy Cooper; Carmel M McConville; D J Munroe; J H Riley; G D Watts; H Ambrose; G McGuire; A D Smith; A Sutcliffe; T Mills; A Malcolm R Taylor
Construction of a transcription map around the gene for ataxia telangiectasia: identification of at least four novel genes.
Genomics 1997;40(2):267-76.
1996: J A Metcalfe; J Parkhill; L Campbell; M Stacey; P Biggs; Philip J Byrd; A Malcolm R Taylor
Accelerated telomere shortening in ataxia telangiectasia.
Nature genetics 1996;13(3):350-3.
1996: J Thick; J A Metcalfe; Y F Mak; D Beatty; M Minegishi; M J Dyer; G Lucas; A Malcolm R Taylor
Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients.
Oncogene 1996;12(2):379-86.
1996: A Malcolm R Taylor; J A Metcalfe; J Thick; Y F Mak
Leukemia and lymphoma in ataxia telangiectasia.
Blood 1996;87(2):423-38.
1996: Philip J Byrd; Carmel M McConville; P Cooper; J Parkhill; Tatjana Stankovic; G M McGuire; J A Thick; A Malcolm R Taylor
Mutations revealed by sequencing the 5' half of the gene for ataxia telangiectasia.
Human molecular genetics 1996;5(1):145-9.
1995: A J Green; J R Yates; A Malcolm R Taylor; P Biggs; G M McGuire; Carmel M McConville; C J Billing; N D Barnes
Severe microcephaly with normal intellectual development: the Nijmegen breakage syndrome.
Archives of disease in childhood 1995;73(5):431-4.
1995: Tatjana Stankovic; Jillian R Mann; P J Darbyshire; A Malcolm R Taylor
Clonal diversity, measured by heterogeneity of Ig and TCR gene rearrangements, in some acute leukaemias of childhood is associated with a more aggressive disease.
European journal of cancer (Oxford, England : 1990) 1995;31A(3):394-401.
1994: Carmel M McConville; Philip J Byrd; H J Ambrose; A Malcolm R Taylor
Genetic and physical mapping of the ataxia-telangiectasia locus on chromosome 11q22-q23.
International journal of radiation biology 1994;66(6 Suppl):S45-56.
1994: A Malcolm R Taylor; Carmel M McConville; Galit Rotman; Yosef Shiloh; Philip J Byrd
A haplotype common to intermediate radiosensitivity variants of ataxia-telangiectasia in the UK.
International journal of radiation biology 1994;66(6 Suppl):S35-41.
1994: A Malcolm R Taylor; Carmel M McConville; Philip J Byrd
Cancer and DNA processing disorders.
British medical bulletin 1994;50(3):708-17.
1994: H J Ambrose; Philip J Byrd; Carmel M McConville; Paul Roy Cooper; Tatjana Stankovic; J H Riley; Yosef Shiloh; J O McNamara; T Fukao; A Malcolm R Taylor
A physical map across chromosome 11q22-q23 containing the major locus for ataxia telangiectasia.
Genomics 1994;21(3):612-9.
1994: J Thick; Y F Mak; J Metcalfe; D Beatty; A Malcolm R Taylor
A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia.
Leukemia 1994;8(4):564-73.
1994: A Malcolm R Taylor; Philip J Byrd; Carmel M McConville; S Thacker
Genetic and cellular features of ataxia telangiectasia.
International journal of radiation biology 1994;65(1):65-70.
1993: C J Formstone; Philip J Byrd; H J Ambrose; J H Riley; D Hernandez; Carmel M McConville; A Malcolm R Taylor
The order and orientation of a cluster of metalloproteinase genes, stromelysin 2, collagenase, and stromelysin, together with D11S385, on chromosome 11q22-q23.
Genomics 1993;16(1):289-91.
1993: G T Gillett; Carmel M McConville; Philip J Byrd; Tatjana Stankovic; A Malcolm R Taylor; David Hunt; L F West; M F Fox; Sue Povey; F J Benham
Irradiation hybrids for human chromosome 11: characterization and use for generating region-specific markers in 11q14-q23.
Genomics 1993;15(2):332-41.
1993: D Hernandez; Carmel M McConville; M Stacey; C G Woods; M M Brown; P Shutt; G Rysiecki; A Malcolm R Taylor
A family showing no evidence of linkage between the ataxia telangiectasia gene and chromosome 11q22-23.
Journal of medical genetics 1993;30(2):135-40.
1993: A Malcolm R Taylor; Nicolaas G J Jaspers; R A Gatti
Fifth International Workshop on Ataxia-Telangiectasia.
Cancer research 1993;53(2):438-41.
1992: Tatjana Stankovic; P Darbyshire; Jillian R Mann; M Pomfret; A Malcolm R Taylor
Rapid production of diversity during the progression of a mixed lineage leukaemia.
Leukemia research 1992;16(10):993-1002.
1992: A Malcolm R Taylor; P A Lowe; M Stacey; J Thick; L Campbell; D Beatty; P Biggs; C J Formstone
Development of T-cell leukaemia in an ataxia telangiectasia patient following clonal selection in t(X;14)-containing lymphocytes.
Leukemia 1992;6(9):961-6.
1991: T Foroud; S Wei; Yehiel Ziv; E Sobel; Ethan M Lange; A Chao; T Goradia; Y Huo; A Tolun; Luciana Chessa; P Charmley; Ozden Sanal; N Salman; C Julier; Patrick Concannon; Carmel M McConville; A Malcolm R Taylor; Yosef Shiloh; S K Lange; Richard A Gatti
Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: linkage analysis of 111 families by an international consortium.
American journal of human genetics 1991;49(6):1263-79.
1991: J A Metcalfe; A Heppell-Parton; Carmel M McConville; A Malcolm R Taylor
Characterization of a B-lymphocyte t(2;14) (p11;q32) translocation from an ataxia telangiectasia patient conferring a proliferative advantage on cells in vitro.
Cytogenetics and cell genetics 1991;56(2):91-8.
1990: Carmel M McConville; C J Formstone; D Hernandez; J Thick; A Malcolm R Taylor
Fine mapping of the chromosome 11q22-23 region using PFGE, linkage and haplotype analysis; localization of the gene for ataxia telangiectasia to a 5cM region flanked by NCAM/DRD2 and STMY/CJ52.75, phi 2.22.
Nucleic acids research 1990;18(15):4335-43.
1990: M L Grant; Rachel Bruton; P J Byrd; Phillip H Gallimore; J C Steele; A Malcolm R Taylor; Roger J A Grand
Sensitivity to ionising radiation of transformed human cells containing mutant ras genes.
Oncogene 1990;5(8):1159-64.
1990: Carmel M McConville; C G Woods; M Farrall; J A Metcalfe; A Malcolm R Taylor
Analysis of 7 polymorphic markers at chromosome 11q22-23 in 35 ataxia telangiectasia families; further evidence of linkage.
Human genetics 1990;85(2):215-20.
1990: C G Woods; S E Bundey; A Malcolm R Taylor
Unusual features in the inheritance of ataxia telangiectasia.
Human genetics 1990;84(6):555-62.
1990: M Stacey; Phillip H Gallimore; Carmel M McConville; A Malcolm R Taylor
Rearrangement of the same chromosome regions in different SV40 transformed human skin keratinocyte lines is associated with tumourigenicity.
Oncogene 1990;5(5):727-39.
1989: A Malcolm R Taylor; J A Metcalfe; Carmel M McConville
Increased radiosensitivity and the basic defect in ataxia telangiectasia.
International journal of radiation biology 1989;56(5):677-84.
1989: M Stacey; S Thacker; A Malcolm R Taylor
Cultured skin keratinocytes from both normal individuals and basal cell naevus syndrome patients are more resistant to gamma-rays and UV light compared with cultured skin fibroblasts.
International journal of radiation biology 1989;56(1):45-58.
1988: A Heppell; S V Butterworth; R J Hollis; A A Kennaugh; D W Beatty; A Malcolm R Taylor
Breakage of the T cell receptor alpha chain locus in non malignant clones from patients with ataxia telangiectasia.
Human genetics 1988;79(4):360-4.
1988: J Michael Lord; J A Thick; Christopher M Bunce; A Malcolm R Taylor; P H Gallimore; D Mills; Geoffrey Brown
Characterization of a novel nuclear envelope protein restricted to certain cell types.
Journal of cell science 1988;90 ( Pt 2)():237-45.
1987: A Malcolm R Taylor; E Flude; B Laher; M Stacey; E McKay; J Watt; S H Green; A E Harding
Variant forms of ataxia telangiectasia.
Journal of medical genetics 1987;24(11):669-77.
1987: Richard J Hollis; A A Kennaugh; S V Butterworth; A Malcolm R Taylor
Growth of large chromosomally abnormal T cell clones in ataxia telangiectasia patients is associated with translocation at 14q11. A model for other T cell neoplasia.
Human genetics 1987;76(4):389-95.
1986: A A Kennaugh; S V Butterworth; R Hollis; R Baer; T H Rabbitts; A Malcolm R Taylor
The chromosome breakpoint at 14q32 in an ataxia telangiectasia t(14;14) T cell clone is different from the 14q32 breakpoint in Burkitts and an inv(14) T cell lymphoma.
Human genetics 1986;73(3):254-9.