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Martine Aiach

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Pascale Gaussem; Martine Alhenc-Gelas; Jean-Louis Thomas; Christilla Bachelot-Loza; Véronique Remones; Fouad Dali Ali; Martine Aiach; Pierre-Yves Scarabin
Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate/17β-estradiol, compared with those of levonorgestrel/ethinyl estradiol. A double-blind, randomised study.
Véronique Picard; Jian-Min Chen; Brigitte Tardy; Marie-Françoise Aillaud; Christine Boiteux-Vergnes; Marie Dreyfus; Joseph Emmerich; Cécile Lavenu-Bombled; Ulrike Nowak-Göttl; Nathalie Trillot; Martine Aiach; Martine Alhenc-Gelas
Detection and characterisation of large SERPINC1 deletions in type I inherited antithrombin deficiency.
David M Smadja; Ivan Bièche; Sophie Susen; Laetitia Mauge; Ingrid Laurendeau; Clément d'Audigier; Françoise Grelac; Joseph Emmerich; Martine Aiach; Pascale Gaussem
Interleukin 8 is differently expressed and modulated by PAR-1 activation in early and late endothelial progenitor cells.

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2011: Pascale Gaussem; Martine Alhenc-Gelas; Jean-Louis Thomas; Christilla Bachelot-Loza; Véronique Remones; Fouad Dali Ali; Martine Aiach; Pierre-Yves Scarabin
Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate/17β-estradiol, compared with those of levonorgestrel/ethinyl estradiol. A double-blind, randomised study.
Thrombosis and haemostasis 2011;105(3):560-7.
2010: Véronique Picard; Jian-Min Chen; Brigitte Tardy; Marie-Françoise Aillaud; Christine Boiteux-Vergnes; Marie Dreyfus; Joseph Emmerich; Cécile Lavenu-Bombled; Ulrike Nowak-Göttl; Nathalie Trillot; Martine Aiach; Martine Alhenc-Gelas
Detection and characterisation of large SERPINC1 deletions in type I inherited antithrombin deficiency.
Human genetics 2010;127(1):45-53.
2009: David M Smadja; Ivan Bièche; Sophie Susen; Laetitia Mauge; Ingrid Laurendeau; Clément d'Audigier; Françoise Grelac; Joseph Emmerich; Martine Aiach; Pascale Gaussem
Interleukin 8 is differently expressed and modulated by PAR-1 activation in early and late endothelial progenitor cells.
Journal of cellular and molecular medicine 2009;13(8B):2534-46.
2009: David M Smadja; Anne Godier; Sophie Susen; René R S Packard; Jean-Noël Fabiani; Martine Aiach; Pascale Gaussem
Endothelial progenitor cells are selectively mobilised immediately after coronary artery bypass grafting or valve surgery.
Thrombosis and haemostasis 2009;101(5):983-5.
2009: Pascale Gaussem; Brian Y Ishida; Pierre Fontana; Clive R Pullinger; John P Khane; Martine Aiach; Christilla Bachelot-Loza; Sophie Gandrille
No influence of the VAMP8 rs1010 single nucleotide polymorphism on platelet functions in vitro.
Journal of cellular and molecular medicine 2009;13(3):601-3.
2009: Delphine Borgel; Eric Durand; Sylvain Clauser; Christilla Bachelot-Loza; Séverine Peyrard; Véronique Remones; Martine Aiach; antoine lafont
Plasma Gas6 levels and coronary artery disease.
Thrombosis and haemostasis 2009;101(1):215-6.
2008: David M Smadja; Ivan Bièche; Jean-Sébastien Silvestre; Stéphane Germain; Adeline Cornet; Ingrid Laurendeau; Jean-Paul Duong Van Huyen; Joseph Emmerich; Michel Vidaud; Martine Aiach; Pascale Gaussem
Bone morphogenetic proteins 2 and 4 are selectively expressed by late outgrowth endothelial progenitor cells and promote neoangiogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(12):2137-43.
2008: Jean-Paul Duong Van Huyen; David M Smadja; Patrick Bruneval; Pascale Gaussem; Liliane Dal Cortivo; Pierre Julia; Jean-Noël Fiessinger; Marina Cavazzana-Calvo; Martine Aiach; Joseph Emmerich
Bone marrow-derived mononuclear cell therapy induces distal angiogenesis after local injection in critical leg ischemia.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008;21(7):837-46.
2008: David M Smadja; Agnès Basire; Aymeric Amelot; Aurélie Conte; Ivan Bièche; Bernard F Le Bonniec; Martine Aiach; Pascale Gaussem
Thrombin bound to a fibrin clot confers angiogenic and haemostatic properties on endothelial progenitor cells.
Journal of cellular and molecular medicine 2008;12(3):975-86.
2008: Jean-Marc Olivot; Julien Labreuche; Thomas De Broucker; Odette Poirier; François Cambien; Martine Aiach; Pierre Amarenco
Thrombomodulin gene polymorphisms in brain infarction and mortality after stroke.
Journal of neurology 2008;255(4):514-9.
2008: Beatrice Saposnik; Elodie Lesteven; Anna Lokajczyk; Charles T Esmon; Martine Aiach; Sophie Gandrille
Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma.
Blood 2008;111(7):3442-51.
2008: Robert Y L Zee; Sherri E Michaud; Kirsti Diehl; Daniel I Chasman; Joseph Emmerich; Pascale Gaussem; Martine Aiach; Paul M Ridker
Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism.
Atherosclerosis 2008;197(2):694-9.
2007: Delphine Borgel; Caroline Bornstain; Pieter H Reitsma; Nicolas Lerolle; Sophie Gandrille; Fouad Dali-Ali; Charles T Esmon; Jean-Yves Fagon; Martine Aiach; Jean-Luc Diehl
A comparative study of the protein C pathway in septic and nonseptic patients with organ failure.
American journal of respiratory and critical care medicine 2007;176(9):878-85.
2007: Véronique Picard; Isabelle Présot; Pierre-Yves Scarabin; Martine Aiach; Joseph Emmerich; Martine Alhenc-Gelas
Antithrombin Cambridge II (A384S): prevalence in patients of the Paris Thrombosis Study (PATHROS).
Blood 2007;110(7):2777-8.
2007: Sylvain Clauser; Séverine Peyrard; Pascale Gaussem; Malvina Crespin; Joseph Emmerich; Martine Aiach; Delphine Borgel
Development of a novel immunoassay for the assessment of plasma Gas6 concentrations and their variation with hormonal status.
Clinical chemistry 2007;53(10):1808-13.
2007: David M Smadja; Ivan Bièche; Dominique Helley; Ingrid Laurendeau; Ghislaine Simonin; Laurent Muller; Martine Aiach; Pascale Gaussem
Increased VEGFR2 expression during human late endothelial progenitor cells expansion enhances in vitro angiogenesis with up-regulation of integrin alpha(6).
Journal of cellular and molecular medicine 2007;11(5):1149-61.
2007: David M Smadja; A Cornet; J Emmerich; Martine Aiach; Pascale Gaussem
Endothelial progenitor cells: characterization, in vitro expansion, and prospects for autologous cell therapy.
Cell biology and toxicology 2007;23(4):223-39.
2007: Martine Alhenc-Gelas; Fabrice Juin; Emmanuelle de Raucourt; Sophie Gandrille; Delphine Borgel; Martine Aiach
Influence of PROS1 gene mutations affecting protein S amino-acid 275 on plasma free protein S measurement.
Thrombosis and haemostasis 2007;97(4):678-80.
2006: David M Smadja; Ivan Bièche; J Emmerich; Martine Aiach; Pascale Gaussem
PAR-1 activation has different effects on the angiogenic activity of endothelial progenitor cells derived from human adult and cord blood.
Journal of thrombosis and haemostasis : JTH 2006;4(12):2729-31.
2006: Martine Aiach; Martine Alhenc-Gelas; Delphine Borgel; Joseph Emmerich; Sophie Gandrille; Véronique Picard
[Coagulation factor mutations and thrombosis].
Médecine sciences : M/S 2006;22(11):985-9.
2006: Jean-Marc Olivot; Julien Labreuche; M H Mahagne; Martine Aiach; Pierre Amarenco
Endogenous tissue-type plasminogen activator and cardioembolic brain infarct subtype.
Journal of thrombosis and haemostasis : JTH 2006;4(11):2513-4.
2006: Jean-Sébastien Hulot; Alessandra Bura; Eric Villard; Michel Azizi; Véronique Remones; Catherine Goyenvalle; Martine Aiach; Philippe Lechat; Pascale Gaussem
Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects.
Blood 2006;108(7):2244-7.
2006: Alessandra Bura; Christilla Bachelot-Loza; F Dali Ali; Martine Aiach; Pascale Gaussem
Role of the P2Y12 gene polymorphism in platelet responsiveness to clopidogrel in healthy subjects.
Journal of thrombosis and haemostasis : JTH 2006;4(9):2096-7.
2006: Pierre Fontana; Sophie Gandrille; Véronique Remones; Annabelle Dupont; Jean-Luc Reny; Martine Aiach; Pascale Gaussem
Identification of functional polymorphisms of the thromboxane A2 receptor gene in healthy volunteers.
Thrombosis and haemostasis 2006;96(3):356-60.
2006: David M Smadja; Ingrid Laurendeau; C Avignon; Michel Vidaud; Martine Aiach; Pascale Gaussem
The angiopoietin pathway is modulated by PAR-1 activation on human endothelial progenitor cells.
Journal of thrombosis and haemostasis : JTH 2006;4(9):2051-8.
2006: Véronique Picard; Ulrike Nowak-Göttl; Christine Biron-Andreani; Marc Fouassier; Corinne Frere; Michèle Goualt-Heilman; Emmanuel de Maistre; Sandra Regina; Lucia Rugeri; Catherine Ternisien; Catherine Trichet; Christine Vergnes; Martine Aiach; Martine Alhenc-Gelas
Molecular bases of antithrombin deficiency: twenty-two novel mutations in the antithrombin gene.
Human mutation 2006;27(6):600.
2006: Khadija Lahlou-Laforet; Martine Alhenc-Gelas; Maurice Pornin; Sarah Bydlowski; Etienne Seigneur; ATHANASE BENETOS; Jean-Michel Kierzin; Pierre-Yves Scarabin; Pierre Ducimetiere; Martine Aiach; Louis Guize; Silla M Consoli
Relation of depressive mood to plasminogen activator inhibitor, tissue plasminogen activator, and fibrinogen levels in patients with versus without coronary heart disease.
The American journal of cardiology 2006;97(9):1287-91.
2006: Sylvain Clauser; Christilla Bachelot-Lozat; Pierre Fontana; Pascale Gaussem; Véronique Remones; Martine Aiach; Delphine Borgel
Physiological plasma Gas6 levels do not influence platelet aggregation.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(3):e22.
2006: F Saller; Tahar Kaabache; Martine Aiach; Sophie Gandrille; Delphine Borgel
The protein S thrombin-sensitive region modulates phospholipid binding and the gamma-carboxyglutamic acid-rich (Gla) domain conformation in a non-specific manner.
Journal of thrombosis and haemostasis : JTH 2006;4(3):704-6.
2006: Delphine Borgel; Sylvain Clauser; Caroline Bornstain; Ivan Bièche; Alvine Bissery; Véronique Remones; Jean-Yves Fagon; Martine Aiach; Jean-Luc Diehl
Elevated growth-arrest-specific protein 6 plasma levels in patients with severe sepsis.
Critical care medicine 2006;34(1):219-22.
2005: David M Smadja; Ivan Bièche; Georges Uzan; Heidi Bompais; Laurent Muller; Catherine Boisson-Vidal; Michel Vidaud; Martine Aiach; Pascale Gaussem
PAR-1 activation on human late endothelial progenitor cells enhances angiogenesis in vitro with upregulation of the SDF-1/CXCR4 system.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(11):2321-7.
2005: Pierre Fontana; Véronique Remones; Jean-Luc Reny; Martine Aiach; Pascale Gaussem
P2Y1 gene polymorphism and ADP-induced platelet response.
Journal of thrombosis and haemostasis : JTH 2005;3(10):2349-50.
2005: Jean-Luc Reny; Véronique Remones; Pierre Fontana; Ivan Bieche; Florence Desvard; Marie-Laurence Aubry; Pascale Gaussen; Martine Aiach
The thrombomodulin-1208/-1209delTT gene promoter polymorphism does not affect basal or LPS-dependent monocyte TM mRNA transcription in healthy volunteers.
Thrombosis and haemostasis 2005;94(3):686-7.
2005: Véronique Picard; Anne Bauters; Mahnouch Khairy; Nadège Ochat; Brigitte Jude; Martine Aiach; Martine Alhenc-Gelas
Conformational Asn187Asp/Lys antithrombin variants and thrombosis. Clinical and biological features in 13 new heterozygotes.
Thrombosis and haemostasis 2005;93(1):57-62.
2005: François Saller; Bruno Villoutreix; Aymeric Amelot; Tahar Kaabache; Bernard F Le Bonniec; Martine Aiach; Sophie Gandrille; Delphine Borgel
The gamma-carboxyglutamic acid domain of anticoagulant protein S is involved in activated protein C cofactor activity, independently of phospholipid binding.
Blood 2005;105(1):122-30.
2004: Mahnouch Khairy; Dominique Lasne; Aymeric Amelot; Malvina Crespin; Francine Rendu; Martine Aiach; Christilla Bachelot-Loza
Polymorphonuclear leukocyte and monocyte activation induced by plasma from patients with heparin-induced thrombocytopenia in whole blood.
Thrombosis and haemostasis 2004;92(6):1411-9.
2004: Agnès Lillo-Le Louët; Pierre Boutouyrie; Martine Alhenc-Gelas; Christine Le Beller; Isabelle Gautier; Martine Aiach; Dominique Lasne
Diagnostic score for heparin-induced thrombocytopenia after cardiopulmonary bypass.
Journal of thrombosis and haemostasis : JTH 2004;2(11):1882-8.
2004: Martine Alhenc-Gelas; Geneviève Plu-Bureau; S Guillonneau; Jean Michel Kirzin; Martine Aiach; N Ochat; Pierre-Yves Scarabin
Impact of progestagens on activated protein C (APC) resistance among users of oral contraceptives.
Journal of thrombosis and haemostasis : JTH 2004;2(9):1594-600.
2004: Jean-Luc Reny; Martine Alhenc-Gelas; Pierre Fontana; Alvine Bissery; Pierre Julia; Jean-Noël Fiessinger; Martine Aiach; Joseph Emmerich
The factor II G20210A gene polymorphism, but not factor V Arg506Gln, is associated with peripheral arterial disease: results of a case-control study.
Journal of thrombosis and haemostasis : JTH 2004;2(8):1334-40.
2004: Jean-Marc Olivot; Julien Labreuche; Martine Aiach; Pierre Amarenco
Soluble thrombomodulin and brain infarction: case-control and prospective study.
Stroke; a journal of cerebral circulation 2004;35(8):1946-51.
2004: Beatrice Saposnik; Jean-Luc Reny; Pascale Gaussem; Joseph Emmerich; Martine Aiach; Sophie Gandrille
A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis.
Blood 2004;103(4):1311-8.
2004: Jean-Luc Reny; Ingrid Laurendeau; Pierre Fontana; Ivan Bièche; Annabelle Dupont; Véronique Remones; Joseph Emmerich; Michel Vidaud; Martine Aiach; Pascale Gaussem
The TF-603A/G gene promoter polymorphism and circulating monocyte tissue factor gene expression in healthy volunteers.
Thrombosis and haemostasis 2004;91(2):248-54.
2003: Pierre Fontana; Pascale Gaussem; Martine Aiach; Jean-Noël Fiessinger; Joseph Emmerich; Jean-Luc Reny
P2Y12 H2 haplotype is associated with peripheral arterial disease: a case-control study.
Circulation 2003;108(24):2971-3.
2003: Sophie Gandrille; Véronique Remones; Martine Aiach
[Validation of a diagnostic kit for factor V Leiden mutation].
Annales de biologie clinique 2003;61(6):723-7.
2003: Emmanuel Oger; Martine Alhenc-Gelas; Karine Lacut; Marie-Thérèse Blouch; Nathalie Roudaut; Véronique Kerlan; Michel Collet; Jean-François Abgrall; Martine Aiach; Pierre-Yves Scarabin; Dominique Mottier
Differential effects of oral and transdermal estrogen/progesterone regimens on sensitivity to activated protein C among postmenopausal women: a randomized trial.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(9):1671-6.
2003: Pierre Fontana; Annabelle Dupont; Sophie Gandrille; Christilla Bachelot-Loza; Jean-Luc Reny; Martine Aiach; Pascale Gaussem
Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects.
Circulation 2003;108(8):989-95.
2003: Véronique Picard; Marie-Dominique Dautzenberg; Bruno Villoutreix; Gilles Orliaguet; Martine Alhenc-Gelas; Martine Aiach
Antithrombin Phe229Leu: a new homozygous variant leading to spontaneous antithrombin polymerization in vivo associated with severe childhood thrombosis.
Blood 2003;102(3):919-25.
2003: Delphine Borgel; Jean-Luc Reny; David Fischelis; Sophie Gandrille; Joseph Emmerich; Jean-Noël Fiessinger; Martine Aiach
Cleaved protein S (PS), total PS, free PS, and activated protein C cofactor activity as risk factors for venous thromboembolism.
Clinical chemistry 2003;49(4):575-80.
2003: Annabelle Dupont; Pierre Fontana; Christilla Bachelot-Loza; Jean-Luc Reny; Ivan Biéche; Florence Desvard; Martine Aiach; Pascale Gaussem
An intronic polymorphism in the PAR-1 gene is associated with platelet receptor density and the response to SFLLRN.
Blood 2003;101(5):1833-40.
2003: Véronique Picard; S Susen; S Bellucci; Martine Aiach; Martine Alhenc-Gelas
Two new antithrombin variants support a role for K114 and R13 in heparin binding.
Journal of thrombosis and haemostasis : JTH 2003;1(2):386-7.
2003: Catherine Boinot; Delphine Borgel; Alain Kitzis; Maryse Guicheteau; Martine Aiach; Martine Alhenc-Gelas
Familial thrombophilia is an oligogenetic disease: involvement of the prothrombin G20210A, PROC and PROS gene mutations.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2003;14(2):191-6.
2003: Béatrice Saposnik; Delphine Borgel; Martine Aiach; Sophie Gandrille
Functional properties of the sex-hormone-binding globulin (SHBG)-like domain of the anticoagulant protein S.
European journal of biochemistry / FEBS 2003;270(3):545-55.
2002: Nejma Ameziane; Cendrine Seguin; Delphine Borgel; Frédéric Fumeron; Didier Moatti; Martine Alhenc-Gelas; Bernard Grandchamp; Martine Aiach; Joseph Emmerich; Dominique de Prost
The -33T-->C polymorphism in intron 7 of the TFPI gene influences the risk of venous thromboembolism, independently of the factor V Leiden and prothrombin mutations.
Thrombosis and haemostasis 2002;88(2):195-9.
2002: Pascale Gaussem; M Dubar; Bernard F Le Bonniec; I Richard-Lordereau; R Jochemsen; Martine Aiach
Dose-effect relationship for several coagulation markers during administration of the direct thrombin inhibitor S 18326 in healthy subjects.
British journal of clinical pharmacology 2002;53(2):147-54.
2001: Delphine Borgel; Pascale Gaussem; C Garbay; Christilla Bachelot-Loza; Tahar Kaabache; Wang-Qing Liu; Brigitte Brohard-Bohn; Bernard F Le Bonniec; Martine Aiach; Sophie Gandrille
Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the gamma-carboxyglutamic acid-rich domain.
The Biochemical journal 2001;360(Pt 2):499-506.
2001: Dominique Lasne; K Tabet; C Bachelot; Martine Aiach
[Heparin induced autoimmune thrombocytopenia: assessment of a rapid functional assay].
Annales de biologie clinique 2001;59(4):423-9.
2001: Mahnouch Khairy; Dominique Lasne; Brigitte Brohard-Bohn; Martine Aiach; Francine Rendu; Christilla Bachelot-Loza
A new approach in the study of the molecular and cellular events implicated in heparin-induced thrombocytopenia. Formation of leukocyte-platelet aggregates.
Thrombosis and haemostasis 2001;85(6):1090-6.
2001: Jean-Marc Olivot; E Estebanell; M Lafay; B Brohard; Martine Aiach; Francine Rendu
Thrombomodulin prolongs thrombin-induced extracellular signal-regulated kinase phosphorylation and nuclear retention in endothelial cells.
Circulation research 2001;88(7):681-7.
2001: L Le Flem; Louise Mennen; Marie-Laurence Aubry; Martine Aiach; Pierre-Yves Scarabin; Joseph Emmerich; Martine Alhenc-Gelas
Thrombomodulin promoter mutations, venous thrombosis, and varicose veins.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(3):445-51.
2001: Martine Alhenc-Gelas; Martine Aiach; P de Moerloose
Venous thromboembolic disease: risk factors and laboratory investigation.
Seminars in vascular medicine 2001;1(1):81-8.
2001: G Meyer; J Emmerich; Dominique Helley; E Arnaud; V Nicaud; M Alhenc-Gelas; Martine Aiach; A Fischer; H Sors; J N Fiessinger
Factors V leiden and II 20210A in patients with symptomatic pulmonary embolism and deep vein thrombosis.
The American journal of medicine 2001;110(1):12-5.
2000: Martine Alhenc-Gelas; Jean-Luc Reny; Marie-Laurence Aubry; Martine Aiach; Joseph Emmerich
The FXIII Val 34 Leu mutation and the risk of venous thrombosis.
Thrombosis and haemostasis 2000;84(6):1117-8.
2000: Sophie Gandrille; Delphine Borgel; Núria Sala; Yolanda Espinosa-Parrilla; Rachel E Simmonds; S Rezende; B Lind; C Mannhalter; I Pabinger; Pieter H Reitsma; C Formstone; D N Cooper; H Saito; K Suzuki; francesco bernardi; Martine Aiach
Protein S deficiency: a database of mutations--summary of the first update.
Thrombosis and haemostasis 2000;84(5):918.
2000: Dominique Lasne; A Fiemeyer; G Chatellier; C Chammas; J F Baron; Martine Aiach
A study of platelet functions with a new analyzer using high shear stress (PFA 100) in patients undergoing coronary artery bypass graft.
Thrombosis and haemostasis 2000;84(5):794-9.
2000: O Morboeuf; Delphine Borgel; Pascale Gaussem; A Vincenot; J L Pittet; Martine Aiach; Sophie Gandrille
Characterization of cleaved plasma protein S with a monoclonal antibody-based assay.
Thrombosis and haemostasis 2000;84(4):604-10.
2000: O Morboeuf; Delphine Borgel; Martine Aiach; Tahar Kaabache; Sophie Gandrille; Pascale Gaussem
Expression and characterization of recombinant protein S with the Ser 460 Pro mutation.
Thrombosis research 2000;100(1):81-8.
2000: Véronique Picard; Alessandra Bura; Joseph Emmerich; Martine Alhenc-Gelas; C Biron; L L Houbouyan-Reveillard; P Molho; A Labatide-Alanore; P Sié; Pierre Toulon; E Verdy; Martine Aiach
Molecular bases of antithrombin deficiency in French families: identification of seven novel mutations in the antithrombin gene.
British journal of haematology 2000;110(3):731-4.
2000: E Arnaud; V Barbalat; V Nicaud; F Cambien; A Evans; C Morrison; D Arveiler; G Luc; J B Ruidavets; Joseph Emmerich; Jean-Noël Fiessinger; Martine Aiach
Polymorphisms in the 5' regulatory region of the tissue factor gene and the risk of myocardial infarction and venous thromboembolism: the ECTIM and PATHROS studies. Etude Cas-Témoins de l'Infarctus du Myocarde. Paris Thrombosis case-control Study.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(3):892-8.
2000: E Arnaud; V Nicaud; O Poirier; Francine Rendu; M Alhenc-Gelas; Jean-Noël Fiessinger; Joseph Emmerich; Martine Aiach
Protective effect of a thrombin receptor (protease-activated receptor 1) gene polymorphism toward venous thromboembolism.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(2):585-92.
2000: Pierre-Emmanuel Marque; R Spuntarelli; Luiz Juliano; Martine Aiach; Bernard F Le Bonniec
The role of Glu(192) in the allosteric control of the S(2)' and S(3)' subsites of thrombin.
The Journal of biological chemistry 2000;275(2):809-16.
2000: Martine Alhenc-Gelas; Sophie Gandrille; Marie-Laurence Aubry; Martine Aiach
Thirty-three novel mutations in the protein C gene. French INSERM network on molecular abnormalities responsible for protein C and protein S.
Thrombosis and haemostasis 2000;83(1):86-92.
1999: E Arnaud; Didier Moatti; Joseph Emmerich; Martine Aiach; Dominique de Prost
No link between the TFPI V264M mutation and venous thromboembolic disease.
Thrombosis and haemostasis 1999;82(1):159-60.
1999: Martine Aiach; V Nicaud; Martine Alhenc-Gelas; Sophie Gandrille; E Arnaud; J Amiral; L Guize; Jean-Noël Fiessinger; Joseph Emmerich
Complex association of protein C gene promoter polymorphism with circulating protein C levels and thrombotic risk.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(6):1573-6.
1999: Martine Aiach
[Interaction of estrogens and genetic risk factors for thrombosis].
Thérapie 1999;54(3):357-61.
1999: Martine Alhenc-Gelas; E Arnaud; V Nicaud; Marie-Laurence Aubry; Jean-Noël Fiessinger; Martine Aiach; Joseph Emmerich
Venous thromboembolic disease and the prothrombin, methylene tetrahydrofolate reductase and factor V genes.
Thrombosis and haemostasis 1999;81(4):506-10.
1999: L Le Flem; Véronique Picard; Joseph Emmerich; Sophie Gandrille; Jean-Noël Fiessinger; Martine Aiach; Martine Alhenc-Gelas
Mutations in promoter region of thrombomodulin and venous thromboembolic disease.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(4):1098-104.
1999: Dominique Lasne; C Lefèbvre; V Nicaud; Jean-François Paul; Martine Aiach; Jean-Noël Fiessinger
Thrombomodulin in patients with Takayasu's arteritis.
Thrombosis and haemostasis 1999;81(3):469-70.
1999: V Picard; Pierre-Emmanuel Marque; F Paolucci; Martine Aiach; Bernard F Le Bonniec
Topology of the stable serpin-protease complexes revealed by an autoantibody that fails to react with the monomeric conformers of antithrombin.
The Journal of biological chemistry 1999;274(8):4586-93.
1999: Martine Alhenc-Gelas; V Nicaud; Sophie Gandrille; van dreden patrick; J Amiral; Marie-Laurence Aubry; Jean-Noël Fiessinger; Joseph Emmerich; Martine Aiach
The factor V gene A4070G mutation and the risk of venous thrombosis.
Thrombosis and haemostasis 1999;81(2):193-7.
1998: A Vincenot; J L Pittet; Martine Aiach; Pascale Gaussem
A monoclonal antibody recognizing the activation domain of protein C in its calcium-free conformation.
FEBS letters 1998;432(1-2):94-7.
1998: O Morboeuf; Martine Aiach; Sophie Gandrille
Lack of sequence variations in the C4b-BP beta-chain in patients with type III protein S deficiency bearing the Ser 460 to Pro mutation: description of two new intragenic isomorphisms in the C4b-BP beta-chain gene (C4BPB).
British journal of haematology 1998;101(1):10-5.
1998: M Lafay; R Laguna; BF Le Bonniec; Dominique Lasne; Martine Aiach; Francine Rendu
Thrombomodulin modulates the mitogenic response to thrombin of human umbilical vein endothelial cells.
Thrombosis and haemostasis 1998;79(4):848-52.
1998: Christilla Bachelot-Loza; R Saffroy; Dominique Lasne; G Chatellier; Martine Aiach; Francine Rendu
Importance of the FcgammaRIIa-Arg/His-131 polymorphism in heparin-induced thrombocytopenia diagnosis.
Thrombosis and haemostasis 1998;79(3):523-8.
1997: Dominique Lasne; M Krenn; V Pingault; E Arnaud; Jean-Noël Fiessinger; Martine Aiach; Francine Rendu
Interdonor variability of platelet response to thrombin receptor activation: influence of PlA2 polymorphism.
British journal of haematology 1997;99(4):801-7.
1997: R Saffroy; Christilla Bachelot-Loza; W H Fridman; Martine Aiach; J L Teillaud; Francine Rendu
Plasma levels of soluble Fc gamma receptors II (sCD32) and III (sCD16) in patients with heparin-induced thrombocytopenia.
Thrombosis and haemostasis 1997;78(2):970-1.
1997: Martine Aiach; Delphine Borgel; Pascale Gaussem; Joseph Emmerich; Martine Alhenc-Gelas; Sophie Gandrille
Protein C and protein S deficiencies.
Seminars in hematology 1997;34(3):205-16.
1997: Delphine Borgel; Sophie Gandrille; Martine Aiach
Protein S deficiency.
Thrombosis and haemostasis 1997;78(1):351-6.
1997: Sophie Gandrille; Delphine Borgel; H Ireland; David A Lane; Rachel E Simmonds; Pieter H Reitsma; C Mannhalter; I Pabinger; H Saito; K Suzuki; C Formstone; D N Cooper; Y Espinosa; Núria Sala; francesco bernardi; Martine Aiach
Protein S deficiency: a database of mutations. For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis.
Thrombosis and haemostasis 1997;77(6):1201-14.
1997: Dominique Lasne; R Saffroy; C Bachelot; A Vincenot; Francine Rendu; T Papo; Martine Aiach; J C Piette
Tests for heparin-induced thrombocytopenia in primary antiphospholipid syndrome.
British journal of haematology 1997;97(4):939.
1996: Martine Aiach; Sophie Gandrille
Molecular basis for protein C hereditary deficiency.
Haemostasis 1996;26 Suppl 4():9-19.
1996: Delphine Borgel; J Duchemin; Martine Alhenc-Gelas; C Matheron; Martine Aiach; Sophie Gandrille
Molecular basis for protein S hereditary deficiency: genetic defects observed in 118 patients with type I and type IIa deficiencies. The French Network on Molecular Abnormalities Responsible for Protein C and Protein S Deficiencies.
The Journal of laboratory and clinical medicine 1996;128(2):218-27.
1996: Delphine Borgel; Brigitte Jude; Martine Aiach; Sophie Gandrille
First case of sporadic protein S deficiency due to a novel candidate mutation, Ala 484-->Pro, in the protein S active gene (PROS1).
Thrombosis and haemostasis 1996;75(6):883-6.
1996: J Duchemin; Jeanne-Yvonne Borg; Delphine Borgel; Marc Vasse; H Lévèque; Martine Aiach; Sophie Gandrille
Five novel mutations of the protein S active gene (PROS 1) in 8 Norman families.
Thrombosis and haemostasis 1996;75(3):437-44.
1996: Martine Aiach; Pascale Gaussem
[Exploration of hemostasis in current practice].
Annales pharmaceutiques françaises 1996;54(1):21-4.
1995: C Bachelot; R Saffroy; S Gandrille; Martine Aiach; Francine Rendu
Role of Fc gamma RIIA gene polymorphism in human platelet activation by monoclonal antibodies.
Thrombosis and haemostasis 1995;74(6):1557-63.
1995: J Duchemin; Sophie Gandrille; Delphine Borgel; P Feurgard; Martine Alhenc-Gelas; C Matheron; M Dreyfus; E Dupuy; Irène Juhan-Vague; Martine Aiach
The Ser 460 to Pro substitution of the protein S alpha (PROS1) gene is a frequent mutation associated with free protein S (type IIa) deficiency.
Blood 1995;86(9):3436-43.
1995: Martine Aiach; Sophie Gandrille; J Emmerich
A review of mutations causing deficiencies of antithrombin, protein C and protein S.
Thrombosis and haemostasis 1995;74(1):81-9.
1995: Sophie Gandrille; J S Greengard; Martine Alhenc-Gelas; I Juhan-Vague; J F Abgrall; Brigitte Jude; John H Griffin; Martine Aiach
Incidence of activated protein C resistance caused by the ARG 506 GLN mutation in factor V in 113 unrelated symptomatic protein C-deficient patients. The French Network on the behalf of INSERM.
Blood 1995;86(1):219-24.
1995: A Vincenot; Pascale Gaussem; J L Pittet; S Debost; Martine Aiach
Amino acids 225-235** of the protein C serine-protease domain are important for the interaction with the thrombin-thrombomodulin complex.
FEBS letters 1995;367(2):153-7.
1995: P Gaussem; V Picard; G Chadeuf; E Arnaud; Martine Aiach
Human thrombin variable region 1, including E39, is involved in interactions with alpha 1-antitrypsin M358R and protein C.
FEBS letters 1995;365(2-3):219-22.
1995: Sophie Gandrille; Martine Alhenc-Gelas; Martine Aiach
A rapid screening method for the factor V Arg506-->Gln mutation.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1995;6(3):245-8.
1995: J Emmerich; Martine Alhenc-Gelas; Sophie Gandrille; C Guichet; J N Fiessinger; Martine Aiach
Mechanism of protein C deficiency in a patient with arginine 358 alpha 1-antitrypsin (Pittsburgh mutation): role in the maintenance of hemostatic balance.
The Journal of laboratory and clinical medicine 1995;125(4):531-9.
1995: M Alhenc-Gelas; J Rossert; C Jacquot; Martine Aiach
Pharmacokinetic study of the low-molecular-weight heparin fraxiparin in patients with nephrotic syndrome.
Nephron 1995;71(2):149-52.
1994: J Emmerich; D Vidaud; Martine Alhenc-Gelas; G Chadeuf; M Gouault-Heilmann; Marie-Françoise Aillaud; Martine Aiach
Three novel mutations of antithrombin inducing high-molecular-mass compounds.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(12):1958-65.
1994: J Emmerich; G Chadeuf; M J Coetzee; Martine Alhenc-Gelas; J N Fiessinger; Martine Aiach
A phenylalanine 402 to leucine mutation is responsible for a stable inactive conformation of antithrombin.
Thrombosis research 1994;76(3):307-15.
1994: Sophie Gandrille; Brigitte Jude; Martine Alhenc-Gelas; J Emmerich; Martine Aiach
First de novo mutations in the protein C gene of two patients with type I deficiency: a missense mutation and a splice site deletion.
Blood 1994;84(8):2566-70.
1994: J Emmerich; G Chadeuf; Martine Alhenc-Gelas; M Gouault-Heilman; Pierre Toulon; J N Fiessinger; Martine Aiach
Molecular basis of antithrombin type I deficiency: the first large in-frame deletion and two novel mutations in exon 6.
Thrombosis and haemostasis 1994;72(4):534-9.
1994: E Arnaud; M Lafay; P Gaussem; V Picard; Martine Jandrot-Perrus; Martine Aiach; Francine Rendu
An autoantibody directed against human thrombin anion-binding exosite in a patient with arterial thrombosis: effects on platelets, endothelial cells, and protein C activation.
Blood 1994;84(6):1843-50.
1994: Delphine Borgel; Sophie Gandrille; Michèle Gouault-Heilmann; Martine Aiach
First frameshift mutation in the active protein S gene associated with a quantitative hereditary deficiency.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1994;5(4):593-600.
1994: Pascale Gaussem; Sophie Gandrille; J Duchemin; J Emmerich; Martine Alhenc-Gelas; Marie-Françoise Aillaud; Martine Aiach
Influence of six mutations of the protein C gene on the Gla domain conformation and calcium affinity.
Thrombosis and haemostasis 1994;71(6):748-54.
1994: Martine Alhenc-Gelas; C Jestin-Le Guernic; J F Vitoux; A Kher; Martine Aiach; J N Fiessinger
Adjusted versus fixed doses of the low-molecular-weight heparin fragmin in the treatment of deep vein thrombosis. Fragmin-Study Group.
Thrombosis and haemostasis 1994;71(6):698-702.
1994: J Duchemin; J L Pittet; M Tartary; S Béguin; Pascale Gaussem; Martine Alhenc-Gelas; Martine Aiach
A new assay based on thrombin generation inhibition to detect both protein C and protein S deficiencies in plasma.
Thrombosis and haemostasis 1994;71(3):331-8.
1994: S Najjam; G Chadeuf; Sophie Gandrille; Martine Aiach
Arg-129 plays a specific role in the conformation of antithrombin and in the enhancement of factor Xa inhibition by the pentasaccharide sequence of heparin.
Biochimica et biophysica acta 1994;1225(2):135-43.
1994: Sophie Gandrille; M Goossens; Martine Aiach
Scanning method to establish the molecular basis of protein C deficiencies.
Human mutation 1994;4(1):20-30.
1994: Dominique Lasne; Francine Rendu; Martine Aiach
[Cellular receptor of thrombin].
Annales de biologie clinique 1994;52(4):257-60.
1993: Sophie Gandrille; Brigitte Jude; Martine Alhenc-Gelas; A Millaire; Martine Aiach
Compound heterozygosity in a family with protein C deficiency illustrating the complexity of the underlying molecular mechanism.
Thrombosis and haemostasis 1993;70(5):747-52.
1993: Sophie Gandrille; Martine Alhenc-Gelas; Pascale Gaussem; Marie-Françoise Aillaud; E Dupuy; I Juhan-Vague; Martine Aiach
Five novel mutations located in exons III and IX of the protein C gene in patients presenting with defective protein C anticoagulant activity.
Blood 1993;82(1):159-68.
1993: Martine Aiach
[Molecular anomalies of coagulation inhibitors].
Nouvelle revue française d'hématologie 1993;35(3):265-6.
1993: Martine Alhenc-Gelas; M L Aubry; Martine Aiach
Contribution of platelet protein S (PS) to PS levels measured in plasma.
Nouvelle revue française d'hématologie 1993;35(5):469-71.
1992: D Vidaud; J Emmerich; Martine Alhenc-Gelas; J Yvart; J N Fiessinger; Martine Aiach
Met 358 to Arg mutation of alpha 1-antitrypsin associated with protein C deficiency in a patient with mild bleeding tendency.
The Journal of clinical investigation 1992;89(5):1537-43.
1992: J M Costa; J N Fiessinger; L Capron; Martine Aiach
Partial characterization of an autoantibody recognizing the secondary binding site(s) of thrombin in a patient with recurrent spontaneous arterial thrombosis.
Thrombosis and haemostasis 1992;67(2):193-9.
1992: Pierre Toulon; Sophie Gandrille; P Remy; G Chadeuf; M H Jouvin; Martine Aiach
Significance of high levels of heparin cofactor II in the plasma and urine of adult patients with nephrotic syndrome.
Nephron 1992;60(2):176-80.
1992: Sophie Gandrille; M Vidaud; Martine Aiach; Martine Alhenc-Gelas; A M Fischer; M Gouault-Heilman; Pierre Toulon; J N Fiessinger; Michel Goossens
Two novel mutations responsible for hereditary type I protein C deficiency: characterization by denaturing gradient gel electrophoresis.
Human mutation 1992;1(6):491-500.
1991: D Vidaud; J Emmerich; M E Sirieix; P Sié; Martine Alhenc-Gelas; Martine Aiach
Molecular basis for antithrombin III type I deficiency: three novel mutations located in exon IV.
Blood 1991;78(9):2305-9.
1991: Sophie Gandrille; D Vidaud; J Emmerich; Eric Clauser; P Sié; J N Fiessinger; Martine Alhenc-Gelas; P Priollet; Martine Aiach
Molecular basis for hereditary antithrombin III quantitative deficiencies: a stop codon in exon IIIa and a frameshift in exon VI.
British journal of haematology 1991;78(3):414-20.
1991: Pierre Toulon; G Chadeuf; J L Bouillot; J Amiral; M Cambillau; Y Sultan; Martine Aiach
Involvement of heparin cofactor II in chymotrypsin neutralization and in the pancreatic proteinase-antiproteinase interaction during acute pancreatitis in man.
European journal of clinical investigation 1991;21(3):303-9.
1991: Pierre Toulon; J F Vitoux; J N Fiessinger; Didier Sicard; Martine Aiach
Heparin cofactor II: an acute phase reactant in patients with deep vein thrombosis.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1991;2(3):435-9.
1991: Pierre Toulon; G Chadeuf; Martine Aiach
Purification of heparin cofactor II from human plasma.
Journal of chromatography 1991;539(2):493-500.
1991: Pierre Toulon; L Moulonguet-Doleris; J M Costa; Martine Aiach
Heparin cofactor II deficiency in renal allograft recipients: no correlation with the development of thrombosis.
Thrombosis and haemostasis 1991;65(1):20-4.
1991: Eric Clauser; Sophie Gandrille; D Vidaud; P Molho Sabatier; J n Fiessinger; Martine Aiach
Genetic diagnosis of qualitative and quantitative antithrombin III deficiencies.
Nouvelle revue française d'hématologie 1991;33(2):141-3.
1990: Sophie Gandrille; Martine Aiach; D A Lane; D Vidaud; P Molho-Sabatier; R Caso; P de Moerloose; J N Fiessinger; Eric Clauser
Important role of arginine 129 in heparin-binding site of antithrombin III. Identification of a novel mutation arginine 129 to glutamine.
The Journal of biological chemistry 1990;265(31):18997-9001.
1990: Pierre Toulon; Sophie Gandrille; J F Vitoux; J N Fiessinger; Y Sultan; Martine Aiach
High total and free protein S in patients with acute deep vein thrombosis.
Thrombosis research 1990;59(1):213-7.
1990: N de Roux; G Chadeuf; P Molho-Sabatier; P F Plouin; Martine Aiach
Clinical and biochemical characterization of antithrombin III Franconville, a variant with Pro 41 Leu mutation.
British journal of haematology 1990;75(2):222-7.
1990: Pascale Gaussem; Sophie Gandrille; P Molho-Sabatier; L Capron; J N Fiessinger; Martine Aiach
A plasma clot lysis assay based on the release of fibrin degradation products: application to the diagnosis of hypofibrinolytic states.
Thrombosis and haemostasis 1990;63(1):76-81.
1989: P Molho-Sabatier; Martine Aiach; I Gaillard; J N Fiessinger; A M Fischer; G Chadeuf; Eric Clauser
Molecular characterization of antithrombin III (ATIII) variants using polymerase chain reaction. Identification of the ATIII Charleville as an Ala 384 Pro mutation.
The Journal of clinical investigation 1989;84(4):1236-42.
1988: Martine Aiach; M Roncato; G Chadeuf; P Dezellus; L Capron; J N Fiessinger
Antithrombin III Avranches, a new variant with defective serine-protease inhibition--comparison with antithrombin III Charleville.
Thrombosis and haemostasis 1988;60(1):94-6.
1988: Sophie Gandrille; M H Jouvin; Pierre Toulon; P Remy; J N Fiessinger; M Roncato; N Moatti; Martine Aiach
A study of fibrinogen and fibrinolysis in 10 adults with nephrotic syndrome.
Thrombosis and haemostasis 1988;59(3):445-50.
1988: Pierre Toulon; J F Vitoux; L Capron; M Roncato; J N Fiessinger; Martine Aiach
Heparin cofactor II in patients with deep venous thrombosis under heparin and oral anticoagulant therapy.
Thrombosis research 1988;49(5):497-500.
1987: Pierre Toulon; J F Vitoux; C Leroy; T Lecomte; M Roncato; Y Motobashi; Martine Aiach; J N Fiessinger
Circulating activities during constant infusion of heparin or a low molecular weight derivative (enoxaparine): failure to demonstrate any circadian variations.
Thrombosis and haemostasis 1987;58(4):1068-72.
1987: Martine Aiach; D François; P Priollet; L Capron; M Roncato; M Alhenc-Gelas; J N Fiessinger
An abnormal antithrombin III (AT III) with low heparin affinity: AT III Clichy.
British journal of haematology 1987;66(4):515-22.
1986: Pierre Toulon; M Rainaut; Martine Aiach; M Roncato; F Daffos; F Forestier
Antithrombin III (ATIII) and heparin cofactor II (HCII) in normal human fetuses (21st-27th week)
Thrombosis and haemostasis 1986;56(2):237.