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Pierre Borgeat

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Julie S Lefebvre; Sylvie Marleau; Valérie Milot; Tania Lévesque; Serge Picard; Nicolas Flamand; Pierre Borgeat
Toll-like receptor ligands induce polymorphonuclear leukocyte migration: key roles for leukotriene B4 and platelet-activating factor.
Mireille St-Onge; Nicolas Flamand; Jordane Biarc; Serge Picard; Line Bouchard; Andrée-Anne Dussault; Cynthia Laflamme; Michael J James; Gillian E Caughey; Leslie G Cleland; Pierre Borgeat; Marc Pouliot
Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils.
Louis Flamand; Michel J Tremblay; Pierre Borgeat
Leukotriene B4 triggers the in vitro and in vivo release of potent antimicrobial agents.

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All Publications

2010: Julie S Lefebvre; Sylvie Marleau; Valérie Milot; Tania Lévesque; Serge Picard; Nicolas Flamand; Pierre Borgeat
Toll-like receptor ligands induce polymorphonuclear leukocyte migration: key roles for leukotriene B4 and platelet-activating factor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(2):637-47.
2007: Mireille St-Onge; Nicolas Flamand; Jordane Biarc; Serge Picard; Line Bouchard; Andrée-Anne Dussault; Cynthia Laflamme; Michael J James; Gillian E Caughey; Leslie G Cleland; Pierre Borgeat; Marc Pouliot
Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils.
Biochimica et biophysica acta 2007;1771(9):1235-45.
2007: Louis Flamand; Michel J Tremblay; Pierre Borgeat
Leukotriene B4 triggers the in vitro and in vivo release of potent antimicrobial agents.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):8036-45.
2007: Kim Hattermann; Serge Picard; Mathieu Borgeat; Patrick Leclerc; Marc Pouliot; Pierre Borgeat
The Toll-like receptor 7/8-ligand resiquimod (R-848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet-activating factor biosynthesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(7):1575-85.
2006: Nicolas Flamand; Serge Picard; L Lemieux; Marc Pouliot; Sylvain G Bourgoin; Pierre Borgeat
Effects of pyrrophenone, an inhibitor of group IVA phospholipase A2, on eicosanoid and PAF biosynthesis in human neutrophils.
British journal of pharmacology 2006;149(4):385-92.
2006: Nicolas Flamand; Julie Lefebvre; Gabriel Lapointe; Serge Picard; Lise Lemieux; Sylvain G Bourgoin; Pierre Borgeat
Inhibition of platelet-activating factor biosynthesis by adenosine and histamine in human neutrophils: involvement of cPLA2alpha and reversal by lyso-PAF.
Journal of leukocyte biology 2006;79(5):1043-51.
2006: Andrée Fortin; Danielle Harbour; Maria Fernandes; Pierre Borgeat; Sylvain G Bourgoin
Differential expression of adenosine receptors in human neutrophils: up-regulation by specific Th1 cytokines and lipopolysaccharide.
Journal of leukocyte biology 2006;79(3):574-85.
2006: Nicolas Flamand; Julie Lefebvre; Marc E Surette; Serge Picard; Pierre Borgeat
Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils.
The Journal of biological chemistry 2006;281(1):129-36.
2006: Hendrick Plante; Serge Picard; Joseph Mancini; Pierre Borgeat
5-Lipoxygenase-activating protein homodimer in human neutrophils: evidence for a role in leukotriene biosynthesis.
The Biochemical journal 2006;393(Pt 1):211-8.
2005: Jean-Sébastien Cadieux; Patrick Leclerc; Mireille St-Onge; Andrée-Anne Dussault; Cynthia Laflamme; Serge Picard; Catherine Ledent; Pierre Borgeat; Marc Pouliot
Potentiation of neutrophil cyclooxygenase-2 by adenosine: an early anti-inflammatory signal.
Journal of cell science 2005;118(Pt 7):1437-47.
2005: Jean Gosselin; Pierre Borgeat; Louis Flamand
Leukotriene B4 protects latently infected mice against murine cytomegalovirus reactivation following allogeneic transplantation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1587-93.
2004: Louis Flamand; Pierre Borgeat; Richard Lalonde; Jean Gosselin
Release of anti-HIV mediators after administration of leukotriene B4 to humans.
The Journal of infectious diseases 2004;189(11):2001-9.
2004: Nicolas Flamand; Hendrick Plante; Serge Picard; Michel Laviolette; Pierre Borgeat
Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP.
British journal of pharmacology 2004;141(4):552-61.
2003: Karin A Zemski Berry; Pierre Borgeat; Jean Gosselin; Louis Flamand; Robert C Murphy
Urinary metabolites of leukotriene B4 in the human subject.
The Journal of biological chemistry 2003;278(27):24449-60.
2003: David Turgeon; Sarah Chouinard; Patrick Belanger; Serge Picard; Jean-Francois Labbe; Pierre Borgeat; Alain Belanger
Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases.
Journal of lipid research 2003;44(6):1182-91.
2003: Caroline Gilbert; Patrice E Poubelle; Pierre Borgeat; Marc Pouliot; Paul H Naccache
Crystal-induced neutrophil activation: VIII. Immediate production of prostaglandin E2 mediated by constitutive cyclooxygenase 2 in human neutrophils stimulated by urate crystals.
Arthritis and rheumatism 2003;48(4):1137-48.
2003: Sonya Grenier; Nicolas Flamand; Julie Pelletier; Paul H Naccache; Pierre Borgeat; Sylvain G Bourgoin
Arachidonic acid activates phospholipase D in human neutrophils; essential role of endogenous leukotriene B4 and inhibition by adenosine A2A receptor engagement.
Journal of leukocyte biology 2003;73(4):530-9.
2002: Marc Pouliot; Marie-Elaine Fiset; Mireille Massé; Paul H Naccache; Pierre Borgeat
Adenosine up-regulates cyclooxygenase-2 in human granulocytes: impact on the balance of eicosanoid generation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):5279-86.
2002: Nicolas Flamand; Marc E Surette; Serge Picard; Sylvain G Bourgoin; Pierre Borgeat
Cyclic AMP-mediated inhibition of 5-lipoxygenase translocation and leukotriene biosynthesis in human neutrophils.
Molecular pharmacology 2002;62(2):250-6.
2002: Nathalie Thibault; Chantal Burelout; Danielle Harbour; Pierre Borgeat; Paul H Naccache; Sylvain G Bourgoin
Occupancy of adenosine A2a receptors promotes fMLP-induced cyclic AMP accumulation in human neutrophils: impact on phospholipase D activity and recruitment of small GTPases to membranes.
Journal of leukocyte biology 2002;71(2):367-77.
2001: Jean Gosselin; Martin Savard; Melanie Tardif; Louis Flamand; Pierre Borgeat
Epstein-Barr virus primes human polymorphonuclear leucocytes for the biosynthesis of leukotriene B4.
Clinical and experimental immunology 2001;126(3):494-502.
2000: Martin Savard; C Bélanger; Michel J Tremblay; Nancy Dumais; Louis Flamand; Pierre Borgeat; Jean Gosselin
EBV suppresses prostaglandin E2 biosynthesis in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6467-73.
2000: Nicolas Flamand; S Boudreault; Serge Picard; M Austin; Marc E Surette; Hendrick Plante; E Krump; M J Vallée; C Gilbert; Paul H Naccache; Michel Laviolette; Pierre Borgeat
Adenosine, a potent natural suppressor of arachidonic acid release and leukotriene biosynthesis in human neutrophils.
American journal of respiratory and critical care medicine 2000;161(2 Pt 2):S88-94.
2000: Nathalie Thibault; Danielle Harbour; Pierre Borgeat; Paul H Naccache; Sylvain G Bourgoin
Adenosine receptor occupancy suppresses chemoattractant-induced phospholipase D activity by diminishing membrane recruitment of small GTPases.
Blood 2000;95(2):519-27.
1999: Marc E Surette; E Krump; Serge Picard; Pierre Borgeat
Activation of leukotriene synthesis in human neutrophils by exogenous arachidonic acid: inhibition by adenosine A(2a) receptor agonists and crucial role of autocrine activation by leukotriene B(4).
Molecular pharmacology 1999;56(5):1055-62.
1999: S Marleau; B Fruteau de Laclos; A B Sanchez; Patrice E Poubelle; Pierre Borgeat
Role of 5-lipoxygenase products in the local accumulation of neutrophils in dermal inflammation in the rabbit.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3449-58.
1999: E Krump; Pierre Borgeat
Adenosine. An endogenous inhibitor of arachidonic acid release and leukotriene biosynthesis in human neutrophils.
Advances in experimental medicine and biology 1999;447():107-15.
1998: Marc E Surette; N Dallaire; N Jean; Serge Picard; Pierre Borgeat
Mechanisms of the priming effect of lipopolysaccharides on the biosynthesis of leukotriene B4 in chemotactic peptide-stimulated human neutrophils.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(14):1521-31.
1998: Marc Pouliot; Caroline Gilbert; Pierre Borgeat; Patrice E Poubelle; Sylvain G Bourgoin; C Créminon; J Maclouf; Shaun R McColl; Paul H Naccache
Expression and activity of prostaglandin endoperoxide synthase-2 in agonist-activated human neutrophils.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(12):1109-23.
1998: L Khamzina; Pierre Borgeat
Correlation of alpha-fetoprotein expression in normal hepatocytes during development with tyrosine phosphorylation and insulin receptor expression.
Molecular biology of the cell 1998;9(5):1093-105.
1998: R Palmantier; H Rocheleau; Michel Laviolette; Joseph Mancini; Pierre Borgeat
Characteristics of leukotriene biosynthesis by human granulocytes in presence of plasma.
Biochimica et biophysica acta 1998;1389(3):187-96.
1998: Pierre Borgeat; Serge Picard; B Battistini; Pierre Sirois
Measurements of arachidonic acid metabolites derived from the lipoxygenase pathways by high-pressure liquid chromatography.
Methods in molecular biology (Clifton, N.J.) 1998;105():209-16.
1998: B Battistini; Serge Picard; Pierre Borgeat; Pierre Sirois
Measurements of prostanoids, leukotrienes, and isoprostanes by enzyme immunoassays.
Methods in molecular biology (Clifton, N.J.) 1998;105():201-7.
1998: B Battistini; Serge Picard; Pierre Borgeat; Pierre Sirois
Extraction and measurements of prostanoids and leukotrienes by radioimmunoassays.
Methods in molecular biology (Clifton, N.J.) 1998;105():187-99.
1997: E Krump; Serge Picard; Joseph Mancini; Pierre Borgeat
Suppression of leukotriene B4 biosynthesis by endogenous adenosine in ligand-activated human neutrophils.
The Journal of experimental medicine 1997;186(8):1401-6.
1997: Jean Gosselin; Pierre Borgeat
Epstein-Barr virus modulates 5-lipoxygenase product synthesis in human peripheral blood mononuclear cells.
Blood 1997;89(6):2122-30.
1997: E Krump; S Boudreault; Marc E Surette; Pierre Borgeat
Effect of GM-CSF on leukotriene B4 synthesis in human neutrophils: facilitation of the priming effect by autologous plasma.
Advances in experimental medicine and biology 1997;400B():583-7.
1996: K Mehindate; Reem Al-Daccak; F Aoudjit; F Damdoumi; M Fortier; Pierre Borgeat; Walid Mourad
Interleukin-4, transforming growth factor beta 1, and dexamethasone inhibit superantigen-induced prostaglandin E2-dependent collagenase gene expression through their action on cyclooxygenase-2 and cytosolic phospholipase A2.
Laboratory investigation; a journal of technical methods and pathology 1996;75(4):529-38.
1996: Marc Pouliot; P P McDonald; E Krump; J A Mancini; Shaun R McColl; P K Weech; Pierre Borgeat
Colocalization of cytosolic phospholipase A2, 5-lipoxygenase, and 5-lipoxygenase-activating protein at the nuclear membrane of A23187-stimulated human neutrophils.
European journal of biochemistry / FEBS 1996;238(1):250-8.
1996: Marc E Surette; M Nadeau; Pierre Borgeat; J Gosselin
Priming of human peripheral blood mononuclear cells with lipopolysaccharides for enhanced arachidonic acid release and leukotriene synthesis.
Journal of leukocyte biology 1996;59(5):709-15.
1996: E Krump; G Lemay; Pierre Borgeat
Adenosine A2 receptor-induced inhibition of leukotriene B4 synthesis in whole blood ex vivo.
British journal of pharmacology 1996;117(8):1639-44.
1995: S Prié; Gaétan Guillemette; Guylain Boulay; Pierre Borgeat; Pierre Sirois
Leukotriene C4 receptors on guinea pig tracheocytes.
The Journal of pharmacology and experimental therapeutics 1995;275(1):312-8.
1995: K Mehindate; Reem Al-Daccak; J M Dayer; B P Kennedy; C Kris; Pierre Borgeat; P E Poubelle; Walid Mourad
Superantigen-induced collagenase gene expression in human IFN-gamma-treated fibroblast-like synoviocytes involves prostaglandin E2. Evidence for a role of cyclooxygenase-2 and cytosolic phospholipase A2.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(7):3570-7.
1995: E Krump; Marc Pouliot; Paul H Naccache; Pierre Borgeat
Leukotriene synthesis in calcium-depleted human neutrophils: arachidonic acid release correlates with calcium influx.
The Biochemical journal 1995;310 ( Pt 2)():681-8.
1994: C Robidoux; Karim Maghni; J Laporte; A Ponton; A Hallée; Pierre Borgeat; Pierre Sirois
Highly purified guinea pig type II pneumocytes have the leukotriene A4 hydrolase but do not express 5-lipoxygenase activity.
Prostaglandins, leukotrienes, and essential fatty acids 1994;51(4):263-70.
1994: E Krump; Pierre Borgeat
Kinetics of 5-lipoxygenase activation, arachidonic acid release, and leukotriene synthesis in human neutrophils: effects of granulocyte-macrophage colony-stimulating factor.
Biochimica et biophysica acta 1994;1213(2):135-9.
1994: S Marleau; N Dallaire; Patrice E Poubelle; Pierre Borgeat
Metabolic disposition of leukotriene B4 (LTB4) and oxidation-resistant analogues of LTB4 in conscious rabbits.
British journal of pharmacology 1994;112(2):654-8.
1994: R Palmantier; Marc E Surette; A Sanchez; P Braquet; Pierre Borgeat
Priming for the synthesis of 5-lipoxygenase products in human blood ex vivo by human granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha.
Laboratory investigation; a journal of technical methods and pathology 1994;70(5):696-704.
1994: Marc Pouliot; P P McDonald; Pierre Borgeat; Shaun R McColl
Granulocyte/macrophage colony-stimulating factor stimulates the expression of the 5-lipoxygenase-activating protein (FLAP) in human neutrophils.
The Journal of experimental medicine 1994;179(4):1225-32.
1994: P P McDonald; Shaun R McColl; P Braquet; Pierre Borgeat
Autocrine enhancement of leukotriene synthesis by endogenous leukotriene B4 and platelet-activating factor in human neutrophils.
British journal of pharmacology 1994;111(3):852-60.
1994: Marc E Surette; A Odeimat; R Palmantier; S Marleau; Patrice E Poubelle; Pierre Borgeat
Reverse-phase high-performance liquid chromatography analysis of arachidonic acid metabolites in plasma after stimulation of whole blood ex vivo.
Analytical biochemistry 1994;216(2):392-400.
1994: Marc Pouliot; P P McDonald; L Khamzina; Pierre Borgeat; Shaun R McColl
Granulocyte-macrophage colony-stimulating factor enhances 5-lipoxygenase levels in human polymorphonuclear leukocytes.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(2):851-8.
1993: P P McDonald; Marc Pouliot; Pierre Borgeat; Shaun R McColl
Induction by chemokines of lipid mediator synthesis in granulocyte-macrophage colony-stimulating factor-treated human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6399-409.
1993: Marc E Surette; R Palmantier; J Gosselin; Pierre Borgeat
Lipopolysaccharides prime whole human blood and isolated neutrophils for the increased synthesis of 5-lipoxygenase products by enhancing arachidonic acid availability: involvement of the CD14 antigen.
The Journal of experimental medicine 1993;178(4):1347-55.
1993: P P McDonald; Marc Pouliot; Pierre Borgeat
Enhancement by GM-CSF of agonist-induced 5-lipoxygenase activation in human neutrophils involves protein synthesis and gene transcription.
Journal of lipid mediators 1993;6(1-3):59-67.
1993: S Marleau; C Fortin; Patrice E Poubelle; Pierre Borgeat
In vivo desensitization to leukotriene B4 (LTB4) in the rabbit. Inhibition of LTB4-induced neutropenia during intravenous infusion of LTB4.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(1):206-13.
1992: S Bourgoin; Patrice E Poubelle; N W Liao; K Umezawa; Pierre Borgeat; Paul H Naccache
Granulocyte-macrophage colony-stimulating factor primes phospholipase D activity in human neutrophils in vitro: role of calcium, G-proteins and tyrosine kinases.
Cellular signalling 1992;4(5):487-500.
1992: P P McDonald; Shaun R McColl; Paul H Naccache; Pierre Borgeat
Activation of the human neutrophil 5-lipoxygenase by leukotriene B4.
British journal of pharmacology 1992;107(1):226-32.
1991: P P McDonald; Shaun R McColl; Paul H Naccache; Pierre Borgeat
Studies on the activation of human neutrophil 5-lipoxygenase induced by natural agonists and Ca2+ ionophore A23187.
The Biochemical journal 1991;280 ( Pt 2)():379-85.
1991: Artur J de Brum-Fernandes; Gaétan Guillemette; Pierre Borgeat; Pierre Sirois
Specific binding sites for leukotriene B4 in guinea pig brain membranes.
The Journal of pharmacology and experimental therapeutics 1991;259(3):1035-42.
1991: Karim Maghni; C Robidoux; J Laporte; A Hallee; Pierre Borgeat; Pierre Sirois
Purification of natural killer-like Kurloff cells and arachidonic acid metabolism.
Prostaglandins 1991;42(3):251-67.
1991: S Bourgoin; Pierre Borgeat; Patrice E Poubelle
Granulocyte-macrophage colony-stimulating factor (GM-CSF) primes human neutrophils for enhanced phosphatidylcholine breakdown by phospholipase D.
Agents and actions 1991;34(1-2):32-4.
1991: Pierre Sirois; Pierre Borgeat; M Lauzière; L Dubé; P Rubin; J Kesterson
Effect of Zileuton (A-64077) on the 5-lipoxygenase activity of human whole blood ex vivo.
Agents and actions 1991;34(1-2):117-20.
1991: Karim Maghni; Artur J de Brum-Fernandes; E Földes-Filep; M Gaudry; Pierre Borgeat; Pierre Sirois
Leukotriene B4 receptors on guinea pig alveolar eosinophils.
The Journal of pharmacology and experimental therapeutics 1991;258(3):784-9.
1991: R Palmantier; Pierre Borgeat
Thrombin-activated platelets promote leukotriene B4 synthesis in polymorphonuclear leucocytes stimulated by physiological agonists.
British journal of pharmacology 1991;103(4):1909-16.
1991: S Prié; Karim Maghni; J Laporte; Pierre Borgeat; Pierre Sirois
Synthesis of eicosanoids by isolated guinea pig tracheocytes.
The American journal of physiology 1991;260(4 Pt 1):L349-55.
1991: J Laporte; A Hallee; Karim Maghni; C Robidoux; Pierre Borgeat; Pierre Sirois
Metabolism of arachidonic acid by guinea pig Clara cells.
Prostaglandins 1991;41(3):263-81.
1991: Shaun R McColl; E Krump; Paul H Naccache; Patrice E Poubelle; P Braquet; M Braquet; Pierre Borgeat
Granulocyte-macrophage colony-stimulating factor increases the synthesis of leukotriene B4 by human neutrophils in response to platelet-activating factor. Enhancement of both arachidonic acid availability and 5-lipoxygenase activation.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(4):1204-11.
1991: Pierre Sirois; Karim Maghni; C Robidoux; A Hallée; J Laporte; S Cloutier; Pierre Borgeat
Metabolism of arachidonic acid by Foà-Kurloff cells from guinea pig lungs and spleen.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():437-40.
1991: A Odeimat; Patrice E Poubelle; Pierre Borgeat
Reverse phase HPLC profiling of arachidonic acid metabolites in blood stimulated ex vivo.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():311-4.
1991: Karim Maghni; C Robidoux; J Laporte; A Hallée; J Carrier; Pierre Borgeat; Pierre Sirois
Metabolism of arachidonic acid by isolated lung cells and transcellular biosynthesis of thromboxanes.
Advances in experimental medicine and biology 1991;314():289-306.
1990: S Bourgoin; E Plante; M Gaudry; Paul H Naccache; Pierre Borgeat; Patrice E Poubelle
Involvement of a phospholipase D in the mechanism of action of granulocyte-macrophage colony-stimulating factor (GM-CSF): priming of human neutrophils in vitro with GM-CSF is associated with accumulation of phosphatidic acid and diradylglycerol.
The Journal of experimental medicine 1990;172(3):767-77.
1990: K Hirata; Karim Maghni; Pierre Borgeat; Pierre Sirois
Guinea pig alveolar eosinophils and macrophages produce leukotriene B4 but no peptido-leukotriene.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(5):1880-5.
1990: Pierre Borgeat; S Picard; P Vallerand; S Bourgoin; A Odeimat; P Sirois; Patrice E Poubelle
Automated on-line extraction and profiling of lipoxygenase products of arachidonic acid by high-performance liquid chromatography.
Methods in enzymology 1990;187():98-116.
1990: Shaun R McColl; E Krump; P P McDonald; M Braquet; Paul H Naccache; Pierre Borgeat
Enhancement of platelet-activating factor-induced leukotriene synthesis in neutrophils by granulocyte-macrophage colony-stimulating factor (GM-CSF): studies on the mechanism of action of GM-CSF.
Journal of lipid mediators 1990;2 Suppl():S119-27.
1989: Shaun R McColl; E Krump; Paul H Naccache; A C Caon; Pierre Borgeat
Activation of the human neutrophil 5-lipoxygenase by exogenous arachidonic acid: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins.
British journal of pharmacology 1989;97(4):1265-73.
1989: Shaun R McColl; E Krump; Paul H Naccache; Pierre Borgeat
Enhancement of human neutrophil leukotriene synthesis by human granulocyte-macrophage colony-stimulating factor.
Agents and actions 1989;27(3-4):465-8.
1989: Patrice E Poubelle; S Bourgoin; Paul H Naccache; Pierre Borgeat
Granulocyte-macrophage colony-stimulating factor (GM-CSF) and opsonization synergistically enhance leukotriene B4 (LTB4) synthesis induced by phagocytosis in human neutrophils.
Agents and actions 1989;27(3-4):388-90.
1989: Paul H Naccache; Shaun R McColl; A C Caon; Pierre Borgeat
Arachidonic acid-induced mobilization of calcium in human neutrophils: evidence for a multicomponent mechanism of action.
British journal of pharmacology 1989;97(2):461-8.
1988: J P Cristol; B Provençal; Pierre Borgeat; Pierre Sirois
Characterization of leukotriene B4 binding sites on guinea pig lung macrophages.
The Journal of pharmacology and experimental therapeutics 1988;247(3):1199-203.
1988: Paul H Naccache; N Faucher; Pierre Borgeat; J C Gasson; J F DiPersio
Granulocyte-macrophage colony-stimulating factor modulates the excitation-response coupling sequence in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(10):3541-6.
1988: J P Cristol; B Provençal; Pierre Borgeat; Pierre Sirois
Specific leukotriene D4 receptors on guinea-pig alveolar macrophages.
Prostaglandins 1988;35(5):747-56.
1988: Paul H Naccache; N Faucher; S Therrien; Pierre Borgeat
Calcium mobilization, actin polymerization and right-angle light scatter responses to leukotriene B4, 12(R)- and 12(S)-hydroxyeicosatetraenoic acid in human neutrophils.
Life sciences 1988;42(6):727-33.
1987: B Fruteau de Laclos; J Maclouf; Patrice E Poubelle; Pierre Borgeat
Conversion of arachidonic acid into 12-oxo derivatives in human platelets. A pathway possibly involving the heme-catalysed transformation of 12-hydroperoxy-eicosatetraenoic acid.
Prostaglandins 1987;33(3):315-37.
1987: Pierre Sirois; M Harczy; P Braquet; Pierre Borgeat; J Maclouf; P Pradelles
Inhibition of the release of prostaglandins, thromboxanes, and leukotrienes from anaphylactic lungs by a platelet-activating factor (PAF) antagonist and its stimulation by PAF.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17B():1033-7.
1985: Pierre Borgeat; M Nadeau; H Salari; Patrice E Poubelle; B Fruteau de Laclos
Leukotrienes: biosynthesis, metabolism, and analysis.
Advances in lipid research 1985;21():47-77.
1984: M Nadeau; B Fruteau de Laclos; S Picard; P Braquet; EJ Corey; Pierre Borgeat
Studies on leukotriene B4 omega-oxidation in human leukocytes.
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire 1984;62(12):1321-6.
1984: Pierre Borgeat; B Fruteau de Laclos; H Rabinovitch; S Picard; P Braquet; J Hébert; M Laviolette
Eosinophil-rich human polymorphonuclear leukocyte preparations characteristically release leukotriene C4 on ionophore A23187 challenge.
The Journal of allergy and clinical immunology 1984;74(3 Pt 2):310-5.
1982: Pierre Borgeat; S Picard; J Drapeau; P Vallerand
Metabolism of arachidonic acid in leukocytes: isolation of a 5,15-dihydroxy-eicosatetraenoic acid.
Lipids 1982;17(10):676-81.
1982: P H Naccache; T F Molski; E L Becker; Pierre Borgeat; S Picard; P Vallerand; R I Sha'afi
Specificity of the effect of lipoxygenase metabolites of arachidonic acid on calcium homeostasis in neutrophils. Correlation with functional activity.
The Journal of biological chemistry 1982;257(15):8608-11.
1982: Pierre Borgeat; B Fruteau de Laclos; S Picard; J Drapeau; P Vallerand; EJ Corey
Studies on the mechanism of formation of the 5S, 12S-dihydroxy-6,8,10,14(E,Z,E,Z)-icosatetraenoic acid in leukocytes.
Prostaglandins 1982;23(5):713-24.
1982: P Sirois; S Roy; Pierre Borgeat; S Picard; P Vallerand
Evidence for a mediator role of thromboxane A2 in the myotropic action of leukotriene B4 (LTB4) on the guinea-pig lung.
Prostaglandins, leukotrienes, and medicine 1982;8(2):157-70.
1982: H J Showell; P H Naccache; Pierre Borgeat; S Picard; P Vallerand; E L Becker; R I Sha'afi
Characterization of the secretory activity of leukotriene B4 toward rabbit neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1982;128(2):811-6.
1982: Pierre Borgeat; B Fruteau de Laclos; S Picard; P Vallerand; P Sirois
Double dioxygenation of arachidonic acid in leukocytes by lipoxygenases.
Advances in prostaglandin, thromboxane, and leukotriene research 1982;9():45-51.
1981: Pierre Borgeat; S Picard; P Vallerand; P Sirois
Transformation of arachidonic acid in leukocytes. Isolation and structural analysis of a novel dihydroxy derivative.
Prostaglandins and medicine 1981;6(6):557-70.