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Paul Taylor

Research Profile

Procedures

X Ray Crystallography

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Chemicals & Drugs

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Shewanella

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Publications

TOP 3
Kun-Yi Hsin; Hugh P Morgan; Steven R Shave; Andrew C Hinton; Paul Taylor; Malcolm D Walkinshaw
EDULISS: a small-molecule database with data-mining and pharmacophore searching capabilities.
Yuande Yang; Elizabeth Moir; George Kontopidis; Paul Taylor; Martin A Wear; Kirk Malone; Colin J Dunsmore; Antony P Page; Nicholas J Turner; Malcolm D Walkinshaw
Structure-based discovery of a family of synthetic cyclophilin inhibitors showing a cyclosporin-A phenotype in Caenorhabditis elegans.
Julia M Richardson; Angela Dawson; Natasha O'Hagan; Paul Taylor; David J Finnegan; Malcolm D Walkinshaw
Mechanism of Mos1 transposition: insights from structural analysis.

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All Publications

2011: Kun-Yi Hsin; Hugh P Morgan; Steven R Shave; Andrew C Hinton; Paul Taylor; Malcolm D Walkinshaw
EDULISS: a small-molecule database with data-mining and pharmacophore searching capabilities.
Nucleic acids research 2011;39(Database issue):D1042-8.
2007: Yuande Yang; Elizabeth Moir; George Kontopidis; Paul Taylor; Martin A Wear; Kirk Malone; Colin J Dunsmore; Antony P Page; Nicholas J Turner; Malcolm D Walkinshaw
Structure-based discovery of a family of synthetic cyclophilin inhibitors showing a cyclosporin-A phenotype in Caenorhabditis elegans.
Biochemical and biophysical research communications 2007;363(4):1013-9.
2006: Julia M Richardson; Angela Dawson; Natasha O'Hagan; Paul Taylor; David J Finnegan; Malcolm D Walkinshaw
Mechanism of Mos1 transposition: insights from structural analysis.
The EMBO journal 2006;25(6):1324-34.
2005: Sofia Papadia; George Tzolovsky; Debiao Zhao; Kevin Leaper; Dorothy Clyde; Paul Taylor; Eva Asscher; Graeme Kirk; Mary Bownes
emc has a role in dorsal appendage fate formation in Drosophila oogenesis.
Mechanisms of development 2005;122(9):961-74.
2005: George Kontopidis; Su-Ying Wu; Daniella I Zheleva; Paul Taylor; Campbell McInnes; David P Lane; Peter M Fischer; Malcolm D Walkinshaw
Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):1871-6.
2004: Christopher G Mowat; Emma L Rothery; Caroline S Miles; Lisa McIver; Mary K Doherty; Katy Drewette; Paul Taylor; Malcolm D Walkinshaw; Stephen K Chapman; Graeme A Reid
Octaheme tetrathionate reductase is a respiratory enzyme with novel heme ligation.
Nature structural & molecular biology 2004;11(10):1023-4.
2004: Julia M Richardson; Lei Zhang; Severine Marcos; David J Finnegan; Marjorie M Harding; Paul Taylor; Malcolm D Walkinshaw
Expression, purification and preliminary crystallographic studies of a single-point mutant of Mos1 mariner transposase.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 5):962-4.
2004: George Kontopidis; Paul Taylor; Malcolm D Walkinshaw
Enzymatic and structural characterization of non-peptide ligand-cyclophilin complexes.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 3):479-85.
2003: Su Ying Wu; Iain W McNae; George Kontopidis; Steven McClue; Campbell McInnes; Kevin J Stewart; Shudong Wang; Daniella I Zheleva; Howard Marriage; David P Lane; Paul Taylor; Peter M Fischer; Malcolm D Walkinshaw
Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop.
Structure (London, England : 1993) 2003;11(4):399-410.
2003: Jacqueline Dornan; Paul Taylor; Malcolm D Walkinshaw
Structures of immunophilins and their ligand complexes.
Current topics in medicinal chemistry 2003;3(12):1392-409.
2002: Xingxing Zang; Paul Taylor; Ji Ming Wang; David J Meyer; Alan L Scott; Malcolm D Walkinshaw; Rick M Maizels
Homologues of human macrophage migration inhibitory factor from a parasitic nematode. Gene cloning, protein activity, and crystal structure.
The Journal of biological chemistry 2002;277(46):44261-7.
2002: Joel D A Tyndall; Supachok Sinchaikul; Linda A Fothergill-Gilmore; Paul Taylor; Malcolm D Walkinshaw
Crystal structure of a thermostable lipase from Bacillus stearothermophilus P1.
Journal of molecular biology 2002;323(5):859-69.
2002: Bryan K Ward; Rudi K Allan; Danny Mok; Suzanna E Temple; Paul Taylor; Jacqueline Dornan; Peter J Mark; Daniel J Shaw; Premlata Kumar; Malcolm D Walkinshaw; Thomas Ratajczak
A structure-based mutational analysis of cyclophilin 40 identifies key residues in the core tetratricopeptide repeat domain that mediate binding to Hsp90.
The Journal of biological chemistry 2002;277(43):40799-809.
2002: Nichola C Picken; Sylvain C P Eschenlauer; Paul Taylor; Antony P Page; Malcolm D Walkinshaw
Structural and biological characterisation of the gut-associated cyclophilin B isoforms from Caenorhabditis elegans.
Journal of molecular biology 2002;322(1):15-25.
2002: Malcolm D Walkinshaw; Paul Taylor; SS Sturrock; C Atanasiu; Torunn Berge; Robert Henderson; J M Edwardson; David T F Dryden
Structure of Ocr from bacteriophage T7, a protein that mimics B-form DNA.
Molecular cell 2002;9(1):187-94.
2001: SS Sturrock; David T F Dryden; C Atanasiu; Jacqueline Dornan; Sandra Bruce; Andy Cronshaw; Paul Taylor; Malcolm D Walkinshaw
Crystallization and preliminary X-ray analysis of ocr, the product of gene 0.3 of bacteriophage T7.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 11):1652-4.
2001: Paul Taylor; M Bilsland; Malcolm D Walkinshaw
A new conformation of the integrin-binding fragment of human VCAM-1 crystallizes in a highly hydrated packing arrangement.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 11):1579-83.
2001: Christopher G Mowat; RK Moysey; Caroline S Miles; David Leys; Mary K Doherty; Paul Taylor; Malcolm D Walkinshaw; Graeme A Reid; Stephen K Chapman
Kinetic and crystallographic analysis of the key active site acid/base arginine in a soluble fumarate reductase.
Biochemistry 2001;40(41):12292-8.
2001: Paul Taylor; Jacqueline Dornan; Amerigo Carrello; Rodney F Minchin; Thomas Ratajczak; Malcolm D Walkinshaw
Two structures of cyclophilin 40: folding and fidelity in the TPR domains.
Structure (London, England : 1993) 2001;9(5):431-8.
2000: Mary K Doherty; SL Pealing; Caroline S Miles; RK Moysey; Paul Taylor; Malcolm D Walkinshaw; Graeme A Reid; Stephen K Chapman
Identification of the active site acid/base catalyst in a bacterial fumarate reductase: a kinetic and crystallographic study.
Biochemistry 2000;39(35):10695-701.
1999: Jacqueline Dornan; Antony P Page; Paul Taylor; S y Wu; Alan D Winter; Holger Husi; Malcolm D Walkinshaw
Biochemical and structural characterization of a divergent loop cyclophilin from Caenorhabditis elegans.
The Journal of biological chemistry 1999;274(49):34877-83.
1999: Paul Taylor; SL Pealing; Graeme A Reid; Stephen K Chapman; Malcolm D Walkinshaw
Structural and mechanistic mapping of a unique fumarate reductase.
Nature structural biology 1999;6(12):1108-12.
1999: Paul Taylor; V Anderson; J Dowden; Sabine L Flitsch; Nicholas J Turner; K Loughran; Malcolm D Walkinshaw
Novel mechanism of inhibition of elastase by beta-lactams is defined by two inhibitor crystal complexes.
The Journal of biological chemistry 1999;274(35):24901-5.
1999: SL Pealing; Dominikus Lysek; Paul Taylor; Dmitriy Alexeev; Graeme A Reid; Stephen K Chapman; Malcolm D Walkinshaw
Crystallization and preliminary X-ray analysis of flavocytochrome c(3), the fumarate reductase from Shewanella frigidimarina.
Journal of structural biology 1999;127(1):76-8.
1999: Jacqueline Dornan; Paul Taylor; Amerigo Carrello; Rodney F Minchin; Thomas Ratajczak; Malcolm D Walkinshaw
Purification, characterization and crystallization in two crystal forms of bovine cyclophilin 40.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 5):1079-82.
1998: vincent mikol; Paul Taylor; J Kallen; Malcolm D Walkinshaw
Conformational differences of an immunosuppressant peptolide in a single crystal and in a crystal complex with human cyclophilin A.
Journal of molecular biology 1998;283(2):451-61.
1998: J Kallen; vincent mikol; Paul Taylor; Malcolm D Walkinshaw
X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A.
Journal of molecular biology 1998;283(2):435-49.
1998: Paul Taylor; Antony P Page; George Kontopidis; Holger Husi; Malcolm D Walkinshaw
The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi.
FEBS letters 1998;425(2):361-6.
1998: Peter Burkhard; Paul Taylor; Malcolm D Walkinshaw
An example of a protein ligand found by database mining: description of the docking method and its verification by a 2.3 A X-ray structure of a thrombin-ligand complex.
Journal of molecular biology 1998;277(2):449-66.
1997: Holger Husi; K Schörgendorfer; G Stempfer; Paul Taylor; Malcolm D Walkinshaw
Prediction of substrate-specific pockets in cyclosporin synthetase.
FEBS letters 1997;414(3):532-6.
1997: Paul Taylor; Holger Husi; George Kontopidis; Malcolm D Walkinshaw
Structures of cyclophilin-ligand complexes.
Progress in biophysics and molecular biology 1997;67(2-3):155-81.
1996: Paul Taylor; vincent mikol; J Kallen; Peter Burkhard; Malcolm D Walkinshaw
Conformational polymorphism in peptidic and nonpeptidic drug molecules.
Biopolymers 1996;40(5):585-92.
1994: J McFarlane; Paul Taylor; SL Pealing; Stephen K Chapman; Graeme A Reid
Flavocytochrome b2: probing domain mobility by introducing disulphide bridges.
Biochemical Society transactions 1994;22(3):280S.