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Patricia Taylor

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Patricia A Taylor; Nick D Bade; Ryan M Kelly; Michelle J Smith; Heather Emily Stefanski; Bruce R Blazar
FTY720 markedly increases alloengraftment but does not eliminate host anti-donor T cells that cause graft rejection on its withdrawal.
Rachelle G Veenstra; Qing Zhou; Ana C Anderson; Ryan Flynn; Mitsuomi Hirashima; Vijay K Kuchroo; Derek Liu; Angela Panoskaltsis-Mortari; Terry B Strom; Patricia A Taylor; Bruce R Blazar
Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells.
Mathangi Srinivasan; Patricia A Taylor; Joseph H Antin; Jeffrey L Browning; Ryan Flynn; Leo Luznik; William Murphy; Angela Panoskaltsis-Mortari; Andrew Price; Ann Ranger; Jerome Ritz; Mark J Shlomchik; Bruce R Blazar
Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans.

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2012: Patricia A Taylor; Nick D Bade; Ryan M Kelly; Michelle J Smith; Heather Emily Stefanski; Bruce R Blazar
FTY720 markedly increases alloengraftment but does not eliminate host anti-donor T cells that cause graft rejection on its withdrawal.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012;18(9):1341-52.
2012: Rachelle G Veenstra; Qing Zhou; Ana C Anderson; Ryan Flynn; Mitsuomi Hirashima; Vijay K Kuchroo; Derek Liu; Angela Panoskaltsis-Mortari; Terry B Strom; Patricia A Taylor; Bruce R Blazar
Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells.
Blood 2012;120(3):682-90.
2012: Mathangi Srinivasan; Patricia A Taylor; Joseph H Antin; Jeffrey L Browning; Ryan Flynn; Leo Luznik; William Murphy; Angela Panoskaltsis-Mortari; Andrew Price; Ann Ranger; Jerome Ritz; Mark J Shlomchik; Bruce R Blazar
Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans.
Blood 2012;119(6):1570-80.
2010: Steven L Highfill; Paulo C Rodriguez; Qing Zhou; Christine A Goetz; Brent H Koehn; Rachelle Veenstra; Patricia A Taylor; Angela Panoskaltsis-Mortari; Jonathan S Serody; David H Munn; Jakub Tolar; Augusto C Ochoa; Bruce R Blazar
Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13.
Blood 2010;116(25):5738-47.
2010: Christine Vogtenhuber; christoph bucher; Steven L Highfill; Lisa K Koch; Emily Goren; Angela Panoskaltsis-Mortari; Patricia A Taylor; Michael A Farrar; Bruce R Blazar
Constitutively active Stat5b in CD4+ T cells inhibits graft-versus-host disease lethality associated with increased regulatory T-cell potency and decreased T effector cell responses.
Blood 2010;116(3):466-74.
2010: Ryan M Kelly; Emily M Goren; Patricia A Taylor; Scott N Mueller; Heather Emily Stefanski; Mark J Osborn; Hamish S Scott; Elena A Komarova; Andrei V Gudkov; Georg A Holländer; Bruce R Blazar
Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation.
Blood 2010;115(5):1088-97.
2009: Steven L Highfill; Ryan M Kelly; Matthew J O'Shaughnessy; Qing Zhou; Lily Xia; Angela Panoskaltsis-Mortari; Patricia A Taylor; Jakub Tolar; Bruce R Blazar
Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of allopriming.
Blood 2009;114(3):693-701.
2008: Patricia A Taylor; Michael J Ehrhardt; Christopher J Lees; Angela Panoskaltsis-Mortari; Arthur M Krieg; Arlene H Sharpe; William Murphy; Jonathan S Serody; Hiroaki Hemmi; Shizuo Akira; Robert B Levy; Bruce R Blazar
TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection.
Blood 2008;112(8):3508-16.
2008: Ryan M Kelly; Steven L Highfill; Angela Panoskaltsis-Mortari; Patricia A Taylor; Richard L Boyd; Georg A Holländer; Bruce R Blazar
Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation.
Blood 2008;111(12):5734-44.
2008: Lisa K Jasperson; christoph bucher; Angela Panoskaltsis-Mortari; Patricia A Taylor; Andrew L Mellor; David H Munn; Bruce R Blazar
Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality.
Blood 2008;111(6):3257-65.
2007: Patricia A Taylor; Michael J Ehrhardt; Christopher J Lees; Jakub Tolar; Brenda J Weigel; Angela Panoskaltsis-Mortari; Jonathan S Serody; Volker Brinkmann; Bruce R Blazar
Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD).
Blood 2007;110(9):3480-8.
2007: Matthew J O'Shaughnessy; Zong-Ming Chen; Irene Gramaglia; Patricia A Taylor; Angela Panoskaltsis-Mortari; Christine Vogtenhuber; Ed Palmer; Thomas Grader-Beck; Vassiliki A Boussiotis; Bruce R Blazar
Elevation of intracellular cyclic AMP in alloreactive CD4(+) T Cells induces alloantigen-specific tolerance that can prevent GVHD lethality in vivo.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(5):530-42.
2007: Patricia A Taylor; Michael J Ehrhardt; Matthew M Roforth; Jessica M Swedin; Angela Panoskaltsis-Mortari; Jonathan S Serody; Bruce R Blazar
Preformed antibody, not primed T cells, is the initial and major barrier to bone marrow engraftment in allosensitized recipients.
Blood 2007;109(3):1307-15.
2005: Christian A Wysocki; Qi Jiang; Angela Panoskaltsis-Mortari; Patricia A Taylor; Karen P McKinnon; Lishan Su; Bruce R Blazar; Jonathan S Serody
Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease.
Blood 2005;106(9):3300-7.
2005: Patricia A Taylor; Angela Panoskaltsis-Mortari; Gordon J Freeman; Arlene H Sharpe; Randolph J Noelle; Alexander Y Rudensky; Tak W Mak; Jonathan S Serody; Bruce R Blazar
Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM).
Blood 2005;105(8):3372-80.
2005: Bruce R Blazar; Patricia A Taylor
Regulatory T cells.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2005;11(2 Suppl 2):46-9.
2004: Patricia A Taylor; Angela Panoskaltsis-Mortari; Jessica M Swedin; Philip J Lucas; Ronald E Gress; Bruce L Levine; Carl H June; Jonathan S Serody; Bruce R Blazar
L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection.
Blood 2004;104(12):3804-12.
2004: Bruce R Blazar; Robert B Levy; Tak W Mak; Angela Panoskaltsis-Mortari; Hiromi Muta; Monica Jones; Melinda Roskos; Jonathan S Serody; Hideo Yagita; Eckhard R Podack; Patricia A Taylor
CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):2933-41.
2004: Martin G Sauer; Marna E Ericson; Brenda J Weigel; Michael J Herron; Angela Panoskaltsis-Mortari; Betsy T Kren; Bruce L Levine; Jonathan S Serody; Carl H June; Patricia A Taylor; Bruce R Blazar
A novel system for simultaneous in vivo tracking and biological assessment of leukemia cells and ex vivo generated leukemia-reactive cytotoxic T cells.
Cancer research 2004;64(11):3914-21.
2004: Wayne Godfrey; Mark R Krampf; Patricia A Taylor; Bruce R Blazar
Ex vivo depletion of alloreactive cells based on CFSE dye dilution, activation antigen selection, and dendritic cell stimulation.
Blood 2004;103(3):1158-65.
2004: Patricia A Taylor; Christopher J Lees; Sylvie Fournier; James P Allison; Arlene H Sharpe; Bruce R Blazar
B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections].
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):34-9.
2003: Bruce R Blazar; Beatriz M Carreno; Angela Panoskaltsis-Mortari; LauraL Carter; Yoshiko Iwai; Hideo Yagita; Hiroyuki Nishimura; Patricia A Taylor
Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1272-7.
2003: Bruce R Blazar; Arlene H Sharpe; Andy I Chen; Angela Panoskaltsis-Mortari; Christopher Lees; Hisaya Akiba; Hideo Yagita; Nigel Killeen; Patricia A Taylor
Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients.
Blood 2003;101(9):3741-8.
2002: Thomas J Waldschmidt; Angela Panoskaltsis-Mortari; Ron T McElmurry; Lorraine T Tygrett; Patricia A Taylor; Bruce R Blazar
Abnormal T cell-dependent B-cell responses in SCID mice receiving allogeneic bone marrow in utero. Severe combined immune deficiency.
Blood 2002;100(13):4557-64.
2002: Brenda J Weigel; Narender Nath; Patricia A Taylor; Angela Panoskaltsis-Mortari; Wei Chen; Arthur M Krieg; Kenneth Brasel; Bruce R Blazar
Comparative analysis of murine marrow-derived dendritic cells generated by Flt3L or GM-CSF/IL-4 and matured with immune stimulatory agents on the in vivo induction of antileukemia responses.
Blood 2002;100(12):4169-76.
2002: Patricia A Taylor; Christopher J Lees; Jessica M Wilson; Michael J Ehrhardt; Matthew T Campbell; Randolph J Noelle; Bruce R Blazar
Combined effects of calcineurin inhibitors or sirolimus with anti-CD40L mAb on alloengraftment under nonmyeloablative conditions.
Blood 2002;100(9):3400-7.
2002: Patricia A Taylor; Thea M Friedman; Robert Korngold; Randolph J Noelle; Bruce R Blazar
Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell.
Blood 2002;99(12):4601-9.
2002: Patricia A Taylor; Christopher J Lees; Bruce R Blazar
The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality.
Blood 2002;99(10):3493-9.
2002: Patricia A Taylor; Ron T McElmurry; Christopher J Lees; David E Harrison; Bruce R Blazar
Allogenic fetal liver cells have a distinct competitive engraftment advantage over adult bone marrow cells when infused into fetal as compared with adult severe combined immunodeficient recipients.
Blood 2002;99(5):1870-2.
2001: Bruce R Blazar; Frederik P Lindberg; E Ingulli; A Panoskaltsis-Mortari; Per-Arne Oldenborg; K Iizuka; W M Yokoyama; Patricia A Taylor
CD47 (integrin-associated protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells.
The Journal of experimental medicine 2001;194(4):541-9.
2001: Bruce R Blazar; A M Krieg; Patricia A Taylor
Synthetic unmethylated cytosine-phosphate-guanosine oligodeoxynucleotides are potent stimulators of antileukemia responses in naive and bone marrow transplant recipients.
Blood 2001;98(4):1217-25.
2001: Patricia A Taylor; Christopher J Lees; H Waldmann; Randolph J Noelle; Bruce R Blazar
Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions.
Blood 2001;98(2):467-74.
2001: Patricia A Taylor; Randolph J Noelle; Bruce R Blazar
CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade.
The Journal of experimental medicine 2001;193(11):1311-8.
2001: A B Pawlowska; S Hashino; H McKenna; Brenda J Weigel; Patricia A Taylor; Bruce R Blazar
In vitro tumor-pulsed or in vivo Flt3 ligand-generated dendritic cells provide protection against acute myelogenous leukemia in nontransplanted or syngeneic bone marrow-transplanted mice.
Blood 2001;97(5):1474-82.
2001: Bruce R Blazar; B S Kwon; Angela Panoskaltsis-Mortari; K B Kwak; J J Peschon; Patricia A Taylor
Ligation of 4-1BB (CDw137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplant recipients.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3174-83.
2000: Angela Panoskaltsis-Mortari; Patricia A Taylor; Jeffrey S Rubin; Aykut Uren; Lisbeth A Welniak; William Murphy; Kate Farrell; David L Lacey; Bruce R Blazar
Keratinocyte growth factor facilitates alloengraftment and ameliorates graft-versus-host disease in mice by a mechanism independent of repair of conditioning-induced tissue injury.
Blood 2000;96(13):4350-6.
2000: Bruce R Blazar; Christopher J Lees; P J Martin; Randolph J Noelle; B Kwon; William Murphy; Patricia A Taylor
Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):4901-9.
2000: Vassiliki A Boussiotis; Gordon J Freeman; Patricia A Taylor; Alla Berezovskaya; I Grass; B R Blazar; Lee M Nadler
p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes.
Nature medicine 2000;6(3):290-7.
2000: Patricia A Taylor; Angela Panoskaltsis-Mortari; R J Noelle; Bruce R Blazar
Analysis of the requirements for the induction of CD4+ T cell alloantigen hyporesponsiveness by ex vivo anti-CD40 ligand antibody.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):612-22.
1999: Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; A H Sharpe; DA Vallera
Opposing roles of CD28:B7 and CTLA-4:B7 pathways in regulating in vivo alloresponses in murine recipients of MHC disparate T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6368-77.
1998: Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; H Yagita; Jonathan Bromberg; DA Vallera
A critical role for CD48 antigen in regulating alloengraftment and lymphohematopoietic recovery after bone marrow transplantation.
Blood 1998;92(11):4453-63.
1998: Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; S K Narula; S R Smith; M G Roncarolo; DA Vallera
Interleukin-10 dose-dependent regulation of CD4+ and CD8+ T cell-mediated graft-versus-host disease.
Transplantation 1998;66(9):1220-9.
1998: Bruce R Blazar; Patricia A Taylor; Ron T McElmurry; L Tian; Angela Panoskaltsis-Mortari; S Lam; C Lees; Thomas J Waldschmidt; DA Vallera
Engraftment of severe combined immune deficient mice receiving allogeneic bone marrow via In utero or postnatal transfer.
Blood 1998;92(10):3949-59.
1998: William Murphy; Lisbeth A Welniak; D D Taub; Robert Wiltrout; Patricia A Taylor; DA Vallera; M Kopf; H Young; Dan Longo; Bruce R Blazar
Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice.
The Journal of clinical investigation 1998;102(9):1742-8.
1998: Bruce R Blazar; Patricia A Taylor; Randolph J Noelle; DA Vallera
CD4(+) T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versus-host disease lethality capacity but retain nominal antigen responses.
The Journal of clinical investigation 1998;102(3):473-82.
1998: Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; DA Vallera
Rapamycin inhibits the generation of graft-versus-host disease- and graft-versus-leukemia-causing T cells by interfering with the production of Th1 or Th1 cytotoxic cytokines.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(11):5355-65.
1997: Bruce R Blazar; Marc K Jenkins; Patricia A Taylor; J White; Angela Panoskaltsis-Mortari; Robert Korngold; DA Vallera
Anti-CD3 epsilon F(ab')2 fragments inhibit T cell expansion in vivo during graft-versus-host disease or the primary immune response to nominal antigen.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):5821-33.
1997: Bruce R Blazar; Patricia A Taylor; M W Boyer; Angela Panoskaltsis-Mortari; J P Allison; DA Vallera
CD28/B7 interactions are required for sustaining the graft-versus-leukemia effect of delayed post-bone marrow transplantation splenocyte infusion in murine recipients of myeloid or lymphoid leukemia cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3460-73.
1997: Angela Panoskaltsis-Mortari; Patricia A Taylor; T M Yaeger; O Douglas Wangensteen; P B Bitterman; David H Ingbar; DA Vallera; Bruce R Blazar
The critical early proinflammatory events associated with idiopathic pneumonia syndrome in irradiated murine allogeneic recipients are due to donor T cell infusion and potentiated by cyclophosphamide.
The Journal of clinical investigation 1997;100(5):1015-27.
1997: Bruce R Blazar; Patricia A Taylor; DA Vallera
CD4+ and CD8+ T cells each can utilize a perforin-dependent pathway to mediate lethal graft-versus-host disease in major histocompatibility complex-disparate recipients.
Transplantation 1997;64(4):571-6.
1997: M W Boyer; DA Vallera; Patricia A Taylor; G S Gray; E Katsanis; K Gorden; Paul J Orchard; Bruce R Blazar
The role of B7 costimulation by murine acute myeloid leukemia in the generation and function of a CD8+ T-cell line with potent in vivo graft-versus-leukemia properties.
Blood 1997;89(9):3477-85.
1997: Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; J Buhlman; J Xu; R A Flavell; Robert Korngold; Randolph J Noelle; DA Vallera
Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):29-39.
1996: Bruce R Blazar; A H Sharpe; Patricia A Taylor; Angela Panoskaltsis-Mortari; G S Gray; Robert Korngold; DA Vallera
Infusion of anti-B7.1 (CD80) and anti-B7.2 (CD86) monoclonal antibodies inhibits murine graft-versus-host disease lethality in part via direct effects on CD4+ and CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3250-9.
1996: D A Vallera; Patricia A Taylor; M B Widmer; Bruce R Blazar
Interleukin-1 alpha-mediated promotion of long-term alloengraftment and short-term neutrophil expansion does not require the presence of either donor or host T cells.
Transplantation 1996;62(5):636-42.
1996: Bruce R Blazar; Patricia A Taylor; J A Bluestone; DA Vallera
Murine gamma/delta-expressing T cells affect alloengraftment via the recognition of nonclassical major histocompatibility complex class Ib antigens.
Blood 1996;87(10):4463-72.
1996: Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; S Sehgal; DA Vallera
In vivo inhibition of cytokine responsiveness and graft-versus-host disease mortality by rapamycin leads to a clinical-pathological syndrome discrete from that observed with cyclosporin A.
Blood 1996;87(9):4001-9.
1996: Bruce R Blazar; Derry C Roopenian; Patricia A Taylor; Gregory J Christianson; Angela Panoskaltsis-Mortari; D A Vallera
Lack of GVHD across classical, single minor histocompatibiliTy (miH) locus barriers in mice.
Transplantation 1996;61(4):619-24.
1996: Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; Terrence Anthony Barrett; J A Bluestone; DA Vallera
Lethal murine graft-versus-host disease induced by donor gamma/delta expressing T cells with specificity for host nonclassical major histocompatibility complex class Ib antigens.
Blood 1996;87(2):827-37.
1995: D A Vallera; Patricia A Taylor; J L Vannice; Angela Panoskaltsis-Mortari; Bruce R Blazar
Interleukin-1 or tumor necrosis factor-alpha antagonists do not inhibit graft-versus-host disease induced across the major histocompatibility barrier in mice.
Transplantation 1995;60(11):1371-4.
1995: D A Vallera; Patricia A Taylor; Angela Panoskaltsis-Mortari; Bruce R Blazar
Therapy for ongoing graft-versus-host disease induced across the major or minor histocompatibility barrier in mice with anti-CD3F(ab')2-ricin toxin A chain immunotoxin.
Blood 1995;86(11):4367-75.
1995: Bruce R Blazar; Patricia A Taylor; DA Vallera
In utero transfer of adult bone marrow cells into recipients with severe combined immunodeficiency disorder yields lymphoid progeny with T- and B-cell functional capabilities.
Blood 1995;86(11):4353-66.
1995: Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; G S Gray; DA Vallera
Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully major histocompatibility complex-disparate donor grafts.
Blood 1995;85(9):2607-18.
1995: Bruce R Blazar; Patricia A Taylor; S Smith; DA Vallera
Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts.
Blood 1995;85(3):842-51.
1994: Bruce R Blazar; Patricia A Taylor; G S Gray; DA Vallera
The role of T cell subsets in regulating the in vivo efficacy of CTLA4-Ig in preventing graft-versus-host disease in recipients of fully MHC or multiple minor histocompatibility-disparate donor inocula.
Transplantation 1994;58(12):1422-6.
1994: Bruce R Blazar; Patricia A Taylor; W E Fitzsimmons; DA Vallera
FK506 inhibits graft-versus-host disease and bone marrow graft rejection in murine recipients of MHC disparate donor grafts by interfering with mature peripheral T cell expansion post-transplantation.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(4):1836-46.
1994: Bruce R Blazar; Patricia A Taylor; P S Linsley; DA Vallera
In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice.
Blood 1994;83(12):3815-25.
1994: Bruce R Blazar; Patricia A Taylor; DA Vallera
In vivo or in vitro anti-CD3 epsilon chain monoclonal antibody therapy for the prevention of lethal murine graft-versus-host disease across the major histocompatibility barrier in mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3665-74.
1994: Bruce R Blazar; Patricia A Taylor; S N Sehgal; DA Vallera
Rapamycin, a potent inhibitor of T-cell function, prevents graft rejection in murine recipients of allogeneic T-cell-depleted donor marrow.
Blood 1994;83(2):600-9.
1993: Bruce R Blazar; Patricia A Taylor; D C Snover; S N Sehgal; DA Vallera
Murine recipients of fully mismatched donor marrow are protected from lethal graft-versus-host disease by the in vivo administration of rapamycin but develop an autoimmune-like syndrome.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(10):5726-41.
1993: Bruce R Blazar; Patricia A Taylor; S N Sehgal; DA Vallera
Rapamycin prolongs survival of murine recipients of fully allogeneic donor grafts when administered during the graft-versus-host disease process.
Annals of the New York Academy of Sciences 1993;685():73-85.
1993: Bruce R Blazar; Patricia A Taylor; D C Snover; J A Bluestone; DA Vallera
Nonmitogenic anti-CD3F(ab')2 fragments inhibit lethal murine graft-versus-host disease induced across the major histocompatibility barrier.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(1):265-77.
1992: Bruce R Blazar; M B Widmer; Patricia A Taylor; DA Vallera
Promotion of murine marrow alloengraftment and hematopoietic recovery across the major histocompatibility barrier by administration of recombinant human interleukin-1 alpha.
Blood 1992;80(6):1614-22.