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Stephen Taylor

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Kerina J Denny; Richard H Finnell; Angela Jeanes; Steven Lisgo; David G Simmons; Leonie K Callaway; Liam G Coulthard; Bogdan Wlodarczyk; Trent Woodruff; Stephen M Taylor
C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice.
Kerina J Denny; Richard H Finnell; Stephen M Taylor; Leonie K Callaway; Liam G Coulthard; Trent Woodruff
Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia.
Rui Li; Stephen M Taylor; Liam G Coulthard; M C L Wu; Trent Woodruff
C5L2: a controversial receptor of complement anaphylatoxin, C5a.

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2013: Kerina J Denny; Richard H Finnell; Angela Jeanes; Steven Lisgo; David G Simmons; Leonie K Callaway; Liam G Coulthard; Bogdan Wlodarczyk; Trent Woodruff; Stephen M Taylor
C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(7):3493-9.
2013: Kerina J Denny; Richard H Finnell; Stephen M Taylor; Leonie K Callaway; Liam G Coulthard; Trent Woodruff
Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia.
Journal of reproductive immunology 2013;97(2):211-6.
2013: Rui Li; Stephen M Taylor; Liam G Coulthard; M C L Wu; Trent Woodruff
C5L2: a controversial receptor of complement anaphylatoxin, C5a.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(3):855-64.
2013: Kerina J Denny; Stephen M Taylor; Trent Woodruff; Leonie K Callaway
Complement in pregnancy: a delicate balance.
American journal of reproductive immunology (New York, N.Y. : 1989) 2013;69(1):3-11.
2012: Dale Pavlovski; Stephen M Taylor; John Thundyil; Rick A Wetsel; Peter N Monk; Trent Woodruff
Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(9):3680-90.
2012: Faith H Brennan; Stephen M Taylor; Trent Woodruff; Aileen J Anderson; Marc J Ruitenberg
Complement activation in the injured central nervous system: another dual-edged sword?
Journal of neuroinflammation 2012;9():137.
2011: Torbjørn Breivik; Per Gjermo; Yngvar Gundersen; Stephen M Taylor; Trent Woodruff; Per Kristian Opstad
Oral treatment with complement factor C5a receptor (CD88) antagonists inhibits experimental periodontitis in rats.
Journal of periodontal research 2011;46(6):643-7.
2011: Liam G Coulthard; Brent Robinson; Ian A Shiels; Stephen M Taylor; Jaclyn Costello; Trent Woodruff
Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis.
Arthritis research & therapy 2011;13(2):R42.
2011: Trent Woodruff; John Thundyil; Sung-Chun Tang; Christopher G Sobey; Stephen M Taylor; Thiruma V Arumugam
Pathophysiology, treatment, and animal and cellular models of human ischemic stroke.
Molecular neurodegeneration 2011;6(1):11.
2010: Trent Woodruff; Rahasson R Ager; Andrea J Tenner; Peter G Noakes; Stephen M Taylor
The role of the complement system and the activation fragment C5a in the central nervous system.
Neuromolecular medicine 2010;12(2):179-92.
2010: John Thundyil; Sung-Chun Tang; Eitan Okun; Kausik Shah; Vardan T Karamyan; Yu-I Li; Trent Woodruff; Stephen M Taylor; Dong-Gyu Jo; Mark P Mattson; Thiruma V Arumugam
Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death.
Experimental & translational stroke medicine 2010;2(1):15.
2009: Helga D Manthey; Trent Woodruff; Stephen M Taylor; Peter N Monk
Complement component 5a (C5a).
The international journal of biochemistry & cell biology 2009;41(11):2114-7.
2009: Lavinia M Proctor; Tyson A Moore; Peter N Monk; Sam D Sanderson; Stephen M Taylor; Trent Woodruff
Complement factors C3a and C5a have distinct hemodynamic effects in the rat.
International immunopharmacology 2009;9(6):800-6.
2009: James W Crane; Gilang P Baiquni; Robert K P Sullivan; John D Lee; Pankaj Sah; Stephen M Taylor; Peter G Noakes; Trent Woodruff
The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres.
Journal of neuroinflammation 2009;6():34.
2008: Michael Morgan; Andrew Bulmer; Trent Woodruff; Lavinia M Proctor; Hua M Williams; Shelli Z Stocks; Sandra Pollitt; Stephen M Taylor; Ian A Shiels
Pharmacokinetics of a C5a receptor antagonist in the rat after different sites of enteral administration.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;33(4-5):390-8.
2008: Trent Woodruff; Kerina J Costantini; Stephen M Taylor; Peter G Noakes
Role of complement in motor neuron disease: animal models and therapeutic potential of complement inhibitors.
Advances in experimental medicine and biology 2008;632():143-58.
2007: Anne-Marie Scola; Adrian Higginbottom; Lynda J Partridge; Robert C Reid; Trent Woodruff; Stephen M Taylor; David P Fairlie; Peter N Monk
The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding.
The Journal of biological chemistry 2007;282(6):3664-71.
2006: Thiruma V Arumugam; Tim Magnus; Trent Woodruff; Lavinia M Proctor; Ian A Shiels; Stephen M Taylor
Complement mediators in ischemia-reperfusion injury.
Clinica chimica acta; international journal of clinical chemistry 2006;374(1-2):33-45.
2006: Lavinia M Proctor; Anna J Strachan; Trent Woodruff; Indumathy B Mahadevan; Hua M Williams; Ian A Shiels; Stephen M Taylor
Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats.
International immunopharmacology 2006;6(8):1224-32.
2006: Trent Woodruff; James W Crane; Lavinia M Proctor; Kathryn M Buller; Annie B Shek; Kurt de Vos; Sandra Pollitt; Hua M Williams; Ian A Shiels; Peter N Monk; Stephen M Taylor
Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(9):1407-17.
2006: Scott Levick; David Loch; Barbara Rolfe; Robert C Reid; David P Fairlie; Stephen M Taylor; Lindsay Brown
Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):7000-7.
2006: Lavinia M Proctor; Trent Woodruff; Prakirti Sharma; Ian A Shiels; Stephen M Taylor
Transdermal pharmacology of small molecule cyclic C5a antagonists.
Advances in experimental medicine and biology 2006;586():329-45.
2005: Trent Woodruff; Sandra Pollitt; Lavinia M Proctor; Shelli Z Stocks; Helga D Manthey; Hua M Williams; Indumathy B Mahadevan; Ian A Shiels; Stephen M Taylor
Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel disease.
The Journal of pharmacology and experimental therapeutics 2005;314(2):811-7.
2005: Adrian Higginbottom; Stuart A Cain; Trent Woodruff; Lavinia M Proctor; Praveen K Madala; Joel D A Tyndall; Stephen M Taylor; David P Fairlie; Peter N Monk
Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site.
The Journal of biological chemistry 2005;280(18):17831-40.
2005: Trent Woodruff; Thiruma V Arumugam; Ian A Shiels; Michelle L Newman; Paul A Ross; Robert C Reid; David P Fairlie; Stephen M Taylor
A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis.
International immunopharmacology 2005;5(5):883-92.
2004: Lavinia M Proctor; Thiruma V Arumugam; Ian A Shiels; Robert C Reid; David P Fairlie; Stephen M Taylor
Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury.
British journal of pharmacology 2004;142(4):756-64.
2004: Thiruma V Arumugam; Trent Woodruff; Shelli Z Stocks; Lavinia M Proctor; Sandra Pollitt; Ian A Shiels; Robert C Reid; David P Fairlie; Stephen M Taylor
Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats.
Journal of hepatology 2004;40(6):934-41.
2004: Thiruma V Arumugam; Ian A Shiels; Trent Woodruff; D Neil Granger; Stephen M Taylor
The role of the complement system in ischemia-reperfusion injury.
Shock (Augusta, Ga.) 2004;21(5):401-9.
2004: Darren R March; Lavinia M Proctor; Martin J Stoermer; Robert Sbaglia; Giovanni Abbenante; Robert C Reid; Trent Woodruff; Khemar Wadi; Natalii Paczkowski; Joel D A Tyndall; Stephen M Taylor; David P Fairlie
Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity.
Molecular pharmacology 2004;65(4):868-79.
2004: Trent Woodruff; Thiruma V Arumugam; Ian A Shiels; Robert C Reid; David P Fairlie; Stephen M Taylor
Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats.
The Journal of surgical research 2004;116(1):81-90.
2003: Trent Woodruff; Thiruma V Arumugam; Ian A Shiels; Robert C Reid; David P Fairlie; Stephen M Taylor
A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5514-20.
2003: Thiruma V Arumugam; Naomi Arnold; Lavinia M Proctor; Michelle Newman; Robert C Reid; Karl A Hansford; David P Fairlie; Ian A Shiels; Stephen M Taylor
Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist.
British journal of pharmacology 2003;140(1):71-80.
2003: Robert C Reid; Giovanni Abbenante; Stephen M Taylor; David P Fairlie
A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug.
The Journal of organic chemistry 2003;68(11):4464-71.
2003: Thiruma V Arumugam; Ian A Shiels; Anna J Strachan; Giovanni Abbenante; David P Fairlie; Stephen M Taylor
A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats.
Kidney international 2003;63(1):134-42.
2002: Thiruma V Arumugam; Ian A Shiels; Solomon B Margolin; Stephen M Taylor; Lindsay Brown
Pirfenidone attenuates ischaemia-reperfusion injury in the rat small intestine.
Clinical and experimental pharmacology & physiology 2002;29(11):996-1000.
2002: Trent Woodruff; Anna J Strachan; Nathan Dryburgh; Ian A Shiels; Robert C Reid; David P Fairlie; Stephen M Taylor
Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat.
Arthritis and rheumatism 2002;46(9):2476-85.
2002: Thiruma V Arumugam; Ian A Shiels; Trent Woodruff; Robert C Reid; David P Fairlie; Stephen M Taylor
Protective effect of a new C5a receptor antagonist against ischemia-reperfusion injury in the rat small intestine.
The Journal of surgical research 2002;103(2):260-7.
2002: Stevo Mirkovic; Anne-Marie L Seymour; Andrew Fenning; Anna J Strachan; Solomon B Margolin; Stephen M Taylor; Lindsay Brown
Attenuation of cardiac fibrosis by pirfenidone and amiloride in DOCA-salt hypertensive rats.
British journal of pharmacology 2002;135(4):961-8.
2001: Anna J Strachan; Ian A Shiels; Robert C Reid; David P Fairlie; Stephen M Taylor
Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist.
British journal of pharmacology 2001;134(8):1778-86.
2001: Shawn M Vogen; Natalii Paczkowski; L Kirnarsky; AJ Short; J B Whitmore; SA Sherman; Stephen M Taylor; Sam D Sanderson
Differential activities of decapeptide agonists of human C5a: the conformational effects of backbone N-methylation.
International immunopharmacology 2001;1(12):2151-62.
2001: G Miric; C Dallemagne; Zoltan Endre; Solomon B Margolin; Stephen M Taylor; Lindsay Brown
Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats.
British journal of pharmacology 2001;133(5):687-94.
2001: Stuart A Cain; Trent Woodruff; Stephen M Taylor; David P Fairlie; Sam D Sanderson; Peter N Monk
Modulation of ligand selectivity by mutation of the first extracellular loop of the human C5a receptor.
Biochemical pharmacology 2001;61(12):1571-9.
2001: Trent Woodruff; Anna J Strachan; Sam D Sanderson; Peter N Monk; AK Wong; David P Fairlie; Stephen M Taylor
Species dependence for binding of small molecule agonist and antagonists to the C5a receptor on polymorphonuclear leukocytes.
Inflammation 2001;25(3):171-7.
2001: Stephen M Taylor; SA Sherman; L Kirnarsky; Sam D Sanderson
Development of response-selective agonists of human C5a anaphylatoxin: conformational, biological, and therapeutic considerations.
Current medicinal chemistry 2001;8(6):675-84.
2001: Shelli Z Stocks; Stephen M Taylor; Ian A Shiels
Transforming growth factor-beta1 induces alpha-smooth muscle actin expression and fibronectin synthesis in cultured human retinal pigment epithelial cells.
Clinical & experimental ophthalmology 2001;29(1):33-7.
2000: Anna J Strachan; Trent Woodruff; G Haaima; David P Fairlie; Stephen M Taylor
A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6560-5.
2000: J T Ulrich; W Cieplak; Natalii Paczkowski; Stephen M Taylor; Sam D Sanderson
Induction of an antigen-specific CTL response by a conformationally biased agonist of human C5a anaphylatoxin as a molecular adjuvant.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5492-8.
1999: Natalii Paczkowski; AM Finch; J B Whitmore; AJ Short; AK Wong; Peter N Monk; Stuart A Cain; David P Fairlie; Stephen M Taylor
Pharmacological characterization of antagonists of the C5a receptor.
British journal of pharmacology 1999;128(7):1461-6.
1999: AJ Short; Natalii Paczkowski; Shawn M Vogen; Sam D Sanderson; Stephen M Taylor
Response-selective C5a agonists: differential effects on neutropenia and hypotension in the rat.
British journal of pharmacology 1999;128(3):511-4.
1999: Ian A Shiels; SD Bowler; Stephen M Taylor
The effects of salbutamol, beclomethasone, and dexamethasone on fibronectin expression by cultured airway smooth muscle cells.
Inflammation 1999;23(4):321-31.
1999: AK Wong; Stephen M Taylor; David P Fairlie
Development of C5a receptor antagonists.
IDrugs : the investigational drugs journal 1999;2(7):686-93.
1999: AM Finch; AK Wong; Natalii Paczkowski; S K Wadi; David J Craik; David P Fairlie; Stephen M Taylor
Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a.
Journal of medicinal chemistry 1999;42(11):1965-74.
1999: Shelli Z Stocks; Ian A Shiels; Stephen M Taylor
Homologous serum-stimulated fibronectin synthesis in human retinal pigmented epithelial cells.
Australian and New Zealand journal of ophthalmology 1999;27(3-4):247-9.
1999: AJ Short; AK Wong; AM Finch; G Haaima; Ian A Shiels; David P Fairlie; Stephen M Taylor
Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat.
British journal of pharmacology 1999;126(3):551-4.
1999: Ian A Shiels; Sam D Sanderson; Stephen M Taylor
Arterially perfused eye model of uveitis.
Australian veterinary journal 1999;77(2):100-4.
1999: Shawn M Vogen; AM Finch; S K Wadi; J Thatcher; Peter N Monk; Stephen M Taylor; Sam D Sanderson
The influence of Lys68 in decepeptide agonists of C5a on C5a receptor binding, activation and selectivity.
The journal of peptide research : official journal of the American Peptide Society 1999;53(1):8-17.
1998: AK Wong; AM Finch; G K Pierens; David J Craik; Stephen M Taylor; David P Fairlie
Small molecular probes for G-protein-coupled C5a receptors: conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a.
Journal of medicinal chemistry 1998;41(18):3417-25.
1998: S Zhang; Ian A Shiels; J S Ambler; Stephen M Taylor
Pirfenidone reduces fibronectin synthesis by cultured human retinal pigment epithelial cells.
Australian and New Zealand journal of ophthalmology 1998;26 Suppl 1():S74-6.
1997: AM Finch; Shawn M Vogen; SA Sherman; L Kirnarsky; Stephen M Taylor; Sam D Sanderson
Biologically active conformer of the effector region of human C5a and modulatory effects of N-terminal receptor binding determinants on activity.
Journal of medicinal chemistry 1997;40(6):877-84.
1997: Richard M Tempero; Michael A Hollingsworth; Michael D Burdick; AM Finch; Stephen M Taylor; Shawn M Vogen; EL Morgan; Sam D Sanderson
Molecular adjuvant effects of a conformationally biased agonist of human C5a anaphylatoxin.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1377-82.
1996: Ian A Shiels; SD Bowler; Stephen M Taylor
Homologous serum increases fibronectin expression and cell adhesion in airway smooth muscle cells.
Inflammation 1996;20(4):373-87.
1996: R Kawatsu; Sam D Sanderson; I Blanco; N Kendall; AM Finch; Stephen M Taylor; David Colcher
Conformationally biased analogs of human C5a mediate changes in vascular permeability.
The Journal of pharmacology and experimental therapeutics 1996;278(1):432-40.
1995: AM Finch; A E Heron; S L Tolhurst; T H Florin; Sam D Sanderson; Stephen M Taylor
The effect of C5a and U46619 on the isolated, perfused human placental lobule: development of a method for the online estimation of tissue fluid accumulation.
Journal of pharmacological and toxicological methods 1995;34(3):133-41.
1995: Sam D Sanderson; L Kirnarsky; SA Sherman; Shawn M Vogen; Om Prakash; JA Ember; AM Finch; Stephen M Taylor
Decapeptide agonists of human C5a: the relationship between conformation and neutrophil response.
Journal of medicinal chemistry 1995;38(18):3669-75.
1995: Ian A Shiels; SD Bowler; Stephen M Taylor
Airway smooth muscle proliferation in asthma: the potential of vascular leakage to contribute to pathogenesis.
Medical hypotheses 1995;45(1):37-40.
1994: Stephen M Taylor; AM Finch; A E Heron; L C Brown; T H Florin
Reversibility of tachyphylaxis to C5A in guinea pig tissues, perfused human placental lobule, and umbilical artery.
Inflammation 1994;18(6):645-57.
1994: Sam D Sanderson; L Kirnarsky; SA Sherman; JA Ember; AM Finch; Stephen M Taylor
Decapeptide agonists of human C5a: the relationship between conformation and spasmogenic and platelet aggregatory activities.
Journal of medicinal chemistry 1994;37(19):3171-80.
1994: Stephen M Taylor; A E Heron; G R Cannell; T H Florin
Pressor effect of ethanol in the isolated perfused human placental lobule.
European journal of pharmacology 1994;270(4):371-4.
1992: JA Ember; Sam D Sanderson; Stephen M Taylor; M Kawahara; TE Hugli
Biologic activity of synthetic analogues of C5a anaphylatoxin.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(10):3165-73.