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Susan Taylor

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Adam C Bastidas; Michael S Deal; Yurong Guo; Jon M Steichen; Jian Wu; Susan S Taylor
Phosphoryl transfer by protein kinase A is captured in a crystal lattice.
Mira Sastri; Jan M Schilling; Sameh Saad Ali; Donald K Blumenthal; Philip Chang; Manjula Darshi; Michele E Day; J Cameron Finley; Heidi Fridolfsson; Hiro Hakozaki; Kristofer J Haushalter; Charles C King; Antonius Koller; Atsushi Miyanohara; Daniel Ng; Mathivadhani Panneerselvam; Hemal H Patel; Susanna Petrosyan; David M Roth; Susan S Taylor
A kinase interacting protein (AKIP1) is a key regulator of cardiac stress.
Yurong Guo; Susan S Taylor; Andrea Wilderman; Lingzhi Zhang; Paul A Insel
Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway.

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All Publications

2013: Adam C Bastidas; Michael S Deal; Yurong Guo; Jon M Steichen; Jian Wu; Susan S Taylor
Phosphoryl transfer by protein kinase A is captured in a crystal lattice.
Journal of the American Chemical Society 2013;135(12):4788-98.
2013: Mira Sastri; Jan M Schilling; Sameh Saad Ali; Donald K Blumenthal; Philip Chang; Manjula Darshi; Michele E Day; J Cameron Finley; Heidi Fridolfsson; Hiro Hakozaki; Kristofer J Haushalter; Charles C King; Antonius Koller; Atsushi Miyanohara; Daniel Ng; Mathivadhani Panneerselvam; Hemal H Patel; Susanna Petrosyan; David M Roth; Susan S Taylor
A kinase interacting protein (AKIP1) is a key regulator of cardiac stress.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(5):E387-96.
2012: Yurong Guo; Susan S Taylor; Andrea Wilderman; Lingzhi Zhang; Paul A Insel
Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway.
Biochemistry 2012;51(46):9323-32.
2012: Manjula Darshi; Anne N Murphy; Kristina N Trinh; Susan S Taylor
Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space.
The Journal of biological chemistry 2012;287(47):39480-91.
2012: Susan S Taylor; Ping Zhang; Ronit Ilouz; Alexandr Kornev
Assembly of allosteric macromolecular switches: lessons from PKA.
Nature reviews. Molecular cell biology 2012;13(10):646-58.
2012: Susan S Taylor; Jon M Steichen; Malik M Keshwani; Alexandr Kornev
Evolution of the eukaryotic protein kinases as dynamic molecular switches.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2012;367(1602):2517-28.
2012: Adam C Bastidas; Michael S Deal; Yurong Guo; Malik M Keshwani; Jon M Steichen; Susan S Taylor
Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase.
Journal of molecular biology 2012;422(2):215-29.
2012: Nina M Haste; Gordon Langsley; Anais Merckx; Hana Talabani; Alex Doo; Susan S Taylor
Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target.
Microbes and infection / Institut Pasteur 2012;14(10):838-50.
2012: Ronit Ilouz; Alexandr Kornev; Yuliang Ma; Donald K Blumenthal; José Bubis; Michael S Deal; Jian Wu; Yun Young Yim; Susan S Taylor
Localization and quaternary structure of the PKA RIβ holoenzyme.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(31):12443-8.
2012: Malik M Keshwani; Christian Klammt; Alexandr Kornev; Yuliang Ma; Senyon Choe; Paul A Insel; Sventja von Daake; Susan S Taylor
Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(20):E1221-9.
2012: Ping Zhang; Michael S Deal; Malik M Keshwani; Alexandr P Kornev; Eric V Smith-Nguyen; Susan S Taylor
Structure and allostery of the PKA RIIβ tetrameric holoenzyme.
Science (New York, N.Y.) 2012;335(6069):712-6.
2012: Jie Yang; Virgil L Woods; Jian Wu; Michael S Deal; Alexandr P Kornev; Sheng Li; Banumathi Sankaran; Jon M Steichen; Susan S Taylor
A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold.
Journal of molecular biology 2012;415(4):666-79.
2011: Christopher K Means; Anne N Murphy; Susanna Petrosyan; Luis F Santana; Rose E Dixon; Matthew G Gold; Taekjip Ha; Ankur Jain; Lorene K Langeberg; Birgitte Lygren; Kjetil Tasken; Susan S Taylor; Amanda L Vega; John D Scott
An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(48):E1227-35.
2011: Michele E Day; Guido M Gaietta; Mira Sastri; Antonius Koller; Mason R Mackey; John D Scott; Guy A Perkins; Mark H Ellisman; Susan S Taylor
Isoform-specific targeting of PKA to multivesicular bodies.
The Journal of cell biology 2011;193(2):347-63.
2011: Jiancheng Hu; Haiyang Yu; Alexandr P Kornev; Jianping Zhao; Erin L Filbert; Susan S Taylor; Andrey S Shaw
Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(15):6067-72.
2011: Angela J Boettcher; Jian Wu; Choel Kim; Jie Yang; Jessica Bruystens; Nikki Cheung; Juniper K Pennypacker; Donald A Blumenthal; Alexandr Kornev; Susan S Taylor
Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme.
Structure (London, England : 1993) 2011;19(2):265-76.
2011: Susan S Taylor; Alexandr Kornev
Protein kinases: evolution of dynamic regulatory proteins.
Trends in biochemical sciences 2011;36(2):65-77.
2011: Manjula Darshi; Vincent L Mendiola; Mason R Mackey; Anne N Murphy; Antonius Koller; Guy A Perkins; Mark H Ellisman; Susan S Taylor
ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function.
The Journal of biological chemistry 2011;286(4):2918-32.
2011: Charles C King; Mira Sastri; Philip Chang; Juniper Pennypacker; Susan S Taylor
The rate of NF-κB nuclear translocation is regulated by PKA and A kinase interacting protein 1.
PloS one 2011;6(4):e18713.
2010: Timothy J Sjoberg; Alexandr Kornev; Susan S Taylor
Dissecting the cAMP-inducible allosteric switch in protein kinase A RIalpha.
Protein science : a publication of the Protein Society 2010;19(6):1213-21.
2010: Susan S Taylor; Alexandr Kornev
Yet another "active" pseudokinase, Erb3.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(18):8047-8.
2010: Alexandr Kornev; Susan S Taylor
Defining the conserved internal architecture of a protein kinase.
Biochimica et biophysica acta 2010;1804(3):440-4.
2010: Ganapathy N Sarma; Francis S Kinderman; Choel Kim; Sventja von Daake; Lirong Chen; Bi-Cheng Wang; Susan S Taylor
Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity.
Structure (London, England : 1993) 2010;18(2):155-66.
2010: Jon M Steichen; Ganesh H Iyer; Sheng Li; S Adrian Saldanha; Michael S Deal; Virgil L Woods; Susan S Taylor
Global consequences of activation loop phosphorylation on protein kinase A.
The Journal of biological chemistry 2010;285(6):3825-32.
2009: Elaine E Thompson; Alexandr Kornev; Natarajan Kannan; Choel Kim; Lynn F Ten Eyck; Susan S Taylor
Comparative surface geometry of the protein kinase family.
Protein science : a publication of the Protein Society 2009;18(10):2016-26.
2009: Robert A Romano; Natarajan Kannan; Alexandr Kornev; Craig J Allison; Susan S Taylor
A chimeric mechanism for polyvalent trans-phosphorylation of PKA by PDK1.
Protein science : a publication of the Protein Society 2009;18(7):1486-97.
2009: Jie Yang; Eileen Kennedy; Jian Wu; Michael S Deal; Juniper K Pennypacker; riya ghosh; Susan S Taylor
Contribution of non-catalytic core residues to activity and regulation in protein kinase A.
The Journal of biological chemistry 2009;284(10):6241-8.
2009: Alexandr Kornev; Susan S Taylor
Pseudokinases: functional insights gleaned from structure.
Structure (London, England : 1993) 2009;17(1):5-7.
2009: Eileen Kennedy; Jie Yang; Lorraine Pillus; Susan S Taylor; riya ghosh
Identifying critical non-catalytic residues that modulate protein kinase A activity.
PloS one 2009;4(3):e4746.
2008: Alexandr Kornev; Susan S Taylor; Lynn F Ten Eyck
A helix scaffold for the assembly of active protein kinases.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14377-82.
2008: Ali Torkamani; Natarajan Kannan; Susan S Taylor; Nicholas J Schork
Congenital disease SNPs target lineage specific structural elements in protein kinases.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):9011-6.
2008: Yuliang Ma; Susan S Taylor
A molecular switch for targeting between endoplasmic reticulum (ER) and mitochondria: conversion of a mitochondria-targeting element into an ER-targeting signal in DAKAP1.
The Journal of biological chemistry 2008;283(17):11743-51.
2008: Natarajan Kannan; Susan S Taylor
Rethinking pseudokinases.
Cell 2008;133(2):204-5.
2008: Alexandr Kornev; Susan S Taylor; Lynn F Ten Eyck
A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains.
PLoS computational biology 2008;4(4):e1000056.
2008: Susan S Taylor; Choel Kim; Cecilia Y Cheng; Simon H J Brown; Jian Wu; Natarajan Kannan
Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design.
Biochimica et biophysica acta 2008;1784(1):16-26.
2008: Natarajan Kannan; Andrew F. Neuwald; Susan S Taylor
Analogous regulatory sites within the alphaC-beta4 loop regions of ZAP-70 tyrosine kinase and AGC kinases.
Biochimica et biophysica acta 2008;1784(1):27-32.
2007: Ganesh S Anand; Matthew Hotchko; Simon H J Brown; Lynn F Ten Eyck; Elizabeth A Komives; Susan S Taylor
R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry.
Journal of molecular biology 2007;374(2):487-99.
2007: Jian Wu; Simon H J Brown; Sventja von Daake; Susan S Taylor
PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity.
Science (New York, N.Y.) 2007;318(5848):274-9.
2007: Neal M Alto; Andrew W Weflen; Matthew J Rardin; Defne Yarar; Cheri S Lazar; Raffi Tonikian; Antonius Koller; Susan S Taylor; Charles Boone; Sachdev S Sidhu; Sandra L Schmid; Gail Hecht; Jack E Dixon
The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways.
The Journal of cell biology 2007;178(7):1265-78.
2007: Choel Kim; Cecilia Y Cheng; S Adrian Saldanha; Susan S Taylor
PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation.
Cell 2007;130(6):1032-43.
2007: Brent R Martin; Thomas J Deerinck; Mark H Ellisman; Susan S Taylor; Roger Y Tsien
Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells.
Chemistry & biology 2007;14(9):1031-42.
2007: Ganesh Anand; Susan S Taylor; David A Johnson
Cyclic-AMP and pseudosubstrate effects on type-I A-kinase regulatory and catalytic subunit binding kinetics.
Biochemistry 2007;46(32):9283-91.
2007: Kenneth Humphries; Juniper K Pennypacker; Susan S Taylor
Redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation.
The Journal of biological chemistry 2007;282(30):22072-9.
2007: Sharmin Schauble; Charles C King; Manjula Darshi; Antonius Koller; Kavita Shah; Susan S Taylor
Identification of ChChd3 as a novel substrate of the cAMP-dependent protein kinase (PKA) using an analog-sensitive catalytic subunit.
The Journal of biological chemistry 2007;282(20):14952-9.
2007: Chinten James Lim; Jaewon Han; Nima Yousefi; Yuliang Ma; Paul S Amieux; G Stanley McKnight; Susan S Taylor; Mark H Ginsberg
Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins.
Nature cell biology 2007;9(4):415-21.
2007: Natarajan Kannan; Susan S Taylor; Yufeng Zhai; J Craig Venter; Gerard Manning
Structural and functional diversity of the microbial kinome.
PLoS biology 2007;5(3):e17.
2007: Natarajan Kannan; Nina M Haste; Susan S Taylor; Andrew F. Neuwald
The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(4):1272-7.
2007: Natarajan Kannan; Jian Wu; Ganesh S Anand; Shibu Yooseph; Andrew F. Neuwald; J Craig Venter; Susan S Taylor
Evolution of allostery in the cyclic nucleotide binding module.
Genome biology 2007;8(12):R264.
2006: S Adrian Saldanha; Gregory Kaler; Howard B Cottam; Ruben Abagyan; Susan S Taylor
Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.
Analytical chemistry 2006;78(24):8265-72.
2006: Alexandr Kornev; Nina M Haste; Susan S Taylor; Lynn F Ten Eyck
Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(47):17783-8.
2006: Francis S Kinderman; Choel Kim; Sventja von Daake; Yuliang Ma; Bao Q Pham; Glen Spraggon; Nguyen-Huu Xuong; Patricia Jennings; Susan S Taylor
A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase.
Molecular cell 2006;24(3):397-408.
2006: Choel Kim; Dominico Vigil; Ganesh Anand; Susan S Taylor
Structure and dynamics of PKA signaling proteins.
European journal of cell biology 2006;85(7):651-4.
2006: Roland H Niedner; Oleksandr V Buzko; Nina M Haste; Ashton Taylor; Michael Gribskov; Susan S Taylor
Protein kinase resource: an integrated environment for phosphorylation research.
Proteins 2006;63(1):78-86.
2006: Dominico Vigil; Donald K Blumenthal; Susan S Taylor; Jill Trewhella
Solution scattering reveals large differences in the global structures of type II protein kinase A isoforms.
Journal of molecular biology 2006;357(3):880-9.
2006: Justin Gullingsrud; Choel Kim; Susan S Taylor; J Andrew McCammon
Dynamic binding of PKA regulatory subunit RI alpha.
Structure (London, England : 1993) 2006;14(1):141-9.
2006: Dominico Vigil; Jung-Hsin Lin; Christoph A Sotriffer; Juniper K Pennypacker; J Andrew McCammon; Susan S Taylor
A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP.
Protein science : a publication of the Protein Society 2006;15(1):113-21.
2005: Susan S Taylor; Choel Kim; Dominico Vigil; Nina M Haste; Jie Yang; Jian Wu; Ganesh S Anand
Dynamics of signaling by PKA.
Biochimica et biophysica acta 2005;1754(1-2):25-37.
2005: Lora L Burns-Hamuro; Yoshitomo Hamuro; Jack S Kim; Paul Sigala; Rosa Fayos; David D Stranz; Patricia Jennings; Susan S Taylor; Virgil L Woods
Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange.
Protein science : a publication of the Protein Society 2005;14(12):2982-92.
2005: Jian Wu; Jie Yang; Natarajan Kannan; Nguyen-Huu Xuong; Lynn F Ten Eyck; Susan S Taylor
Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix.
Protein science : a publication of the Protein Society 2005;14(11):2871-9.
2005: Dominico Vigil; Donald K Blumenthal; Susan S Taylor; Jill Trewhella
The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding.
The Journal of biological chemistry 2005;280(42):35521-7.
2005: Susan S Taylor; Nina M Haste; riya ghosh
PKR and eIF2alpha: integration of kinase dimerization, activation, and substrate docking.
Cell 2005;122(6):823-5.
2005: Jin Zhang; Christopher J Hupfeld; Susan S Taylor; Jerrold M Olefsky; Roger Y Tsien
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes.
Nature 2005;437(7058):569-73.
2005: Ganesh H Iyer; Siv Garrod; Virgil L Woods; Susan S Taylor
Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase.
Journal of molecular biology 2005;351(5):1110-22.
2005: Ganesh H Iyer; Michael J Moore; Susan S Taylor
Consequences of lysine 72 mutation on the phosphorylation and activation state of cAMP-dependent kinase.
The Journal of biological chemistry 2005;280(10):8800-7.
2005: Choel Kim; Nguyen-Huu Xuong; Susan S Taylor
Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA.
Science (New York, N.Y.) 2005;307(5710):690-6.
2005: Kenneth Humphries; Michael S Deal; Susan S Taylor
Enhanced dephosphorylation of cAMP-dependent protein kinase by oxidation and thiol modification.
The Journal of biological chemistry 2005;280(4):2750-8.
2005: Helen M Berman; Lynn F Ten Eyck; David S Goodsell; Nina M Haste; Alexandr Kornev; Susan S Taylor
The cAMP binding domain: an ancient signaling module.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(1):45-50.
2004: Yoshitomo Hamuro; Ganesh S Anand; Jack S Kim; Celina Juliano; David D Stranz; Susan S Taylor; Virgil L Woods
Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS).
Journal of molecular biology 2004;340(5):1185-96.
2004: Jian Wu; Simon Brown; Nguyen-Huu Xuong; Susan S Taylor
RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B.
Structure (London, England : 1993) 2004;12(6):1057-65.
2004: Jian Wu; John M Jones; Xuong Nguyen-Huu; Lynn F Ten Eyck; Susan S Taylor
Crystal structures of RIalpha subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase complexed with (Rp)-adenosine 3',5'-cyclic monophosphothioate and (Sp)-adenosine 3',5'-cyclic monophosphothioate, the phosphothioate analogues of cAMP.
Biochemistry 2004;43(21):6620-9.
2004: Dominico Vigil; Donald K Blumenthal; Simon Brown; Susan S Taylor; Jill Trewhella
Differential effects of substrate on type I and type II PKA holoenzyme dissociation.
Biochemistry 2004;43(19):5629-36.
2004: William T Heller; Dominico Vigil; Simon Brown; Donald K Blumenthal; Susan S Taylor; Jill Trewhella
C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change.
The Journal of biological chemistry 2004;279(18):19084-90.
2004: Dominico Vigil; Donald K Blumenthal; William T Heller; Simon Brown; Jaume M Canaves; Susan S Taylor; Jill Trewhella
Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions.
Journal of molecular biology 2004;337(5):1183-94.
2004: Kerri M Zawadzki; Susan S Taylor
cAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMP.
The Journal of biological chemistry 2004;279(8):7029-36.
2004: Jie Yang; Lynn F Ten Eyck; Nguyen-Huu Xuong; Susan S Taylor
Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism.
Journal of molecular biology 2004;336(2):473-87.
2004: Pearl Akamine; Laurence L Brunton; Horng D Ou; Jaume M Canaves; Nguyen-Huu Xuong; Susan S Taylor
Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit.
Biochemistry 2004;43(1):85-96.
2003: Ganesh S Anand; Dennis Law; Jeffrey G Mandell; Aaron N Snead; Igor Tsigelny; Susan S Taylor; Lynn F Ten Eyck; Elizabeth A Komives
Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13264-9.
2003: Kerri M Zawadzki; Yoshitomo Hamuro; Jack S Kim; Siv Garrod; David D Stranz; Susan S Taylor; Virgil L Woods
Dissecting interdomain communication within cAPK regulatory subunit type IIbeta using enhanced amide hydrogen/deuterium exchange mass spectrometry (DXMS).
Protein science : a publication of the Protein Society 2003;12(9):1980-90.
2003: Poopak Banky; Melinda Roy; Marceen G Newlon; Dimitrios Morikis; Nina M Haste; Susan S Taylor; Patricia Jennings
Related protein-protein interaction modules present drastically different surface topographies despite a conserved helical platform.
Journal of molecular biology 2003;330(5):1117-29.
2003: Kerri M Zawadzki; Chia-Pin Pan; Mary D Barkley; David Johnson; Susan S Taylor
Endogenous tryptophan residues of cAPK regulatory subunit type IIbeta reveal local variations in environments and dynamics.
Proteins 2003;51(4):552-61.
2003: Lora L Burns; Jaume M Canaves; Juniper K Pennypacker; Donald K Blumenthal; Susan S Taylor
Isoform specific differences in binding of a dual-specificity A-kinase anchoring protein to type I and type II regulatory subunits of PKA.
Biochemistry 2003;42(19):5754-63.
2003: Yoshitomo Hamuro; Kerri M Zawadzki; Jack S Kim; David D Stranz; Susan S Taylor; Virgil L Woods
Dynamics of cAPK type IIbeta activation revealed by enhanced amide H/2H exchange mass spectrometry (DXMS).
Journal of molecular biology 2003;327(5):1065-76.
2003: Stefan Kammerer; Lora L Burns-Hamuro; Yuliang Ma; Sara C Hamon; Jaume M Canaves; Michael M Shi; Matthew Nelson; Charles F Sing; Charles R Cantor; Susan S Taylor; Andreas Braun
Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4066-71.
2003: Lora L Burns-Hamuro; Yuliang Ma; Stefan Kammerer; Ulrich Reineke; Chris Self; Charles Cook; Gary L Olson; Charles R Cantor; Andreas Braun; Susan S Taylor
Designing isoform-specific peptide disruptors of protein kinase A localization.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4072-7.
2003: Michael J Moore; Joseph A Adams; Susan S Taylor
Structural basis for peptide binding in protein kinase A. Role of glutamic acid 203 and tyrosine 204 in the peptide-positioning loop.
The Journal of biological chemistry 2003;278(12):10613-8.
2003: Pearl Akamine; Jian Wu; Nguyen-Huu Xuong; Lynn F Ten Eyck; Susan S Taylor
Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure.
Journal of molecular biology 2003;327(1):159-71.
2002: Michael J Moore; Joan R Kanter; K C Jones; Susan S Taylor
Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1.
The Journal of biological chemistry 2002;277(49):47878-84.
2002: Kenneth Humphries; Celina Juliano; Susan S Taylor
Regulation of cAMP-dependent protein kinase activity by glutathionylation.
The Journal of biological chemistry 2002;277(45):43505-11.
2002: Ganesh S Anand; Carrie A Hughes; John M Jones; Susan S Taylor; Elizabeth A Komives
Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A.
Journal of molecular biology 2002;323(2):377-86.
2002: Scott A Lesley; Peter Kuhn; Adam Godzik; Ashley M Deacon; Irimpan I Mathews; Andreas Kreusch; Glen Spraggon; Heath E Klock; Daniel McMullan; Tanya Shin; Juli Vincent; Alyssa Robb; Linda S Brinen; Mitchell D Miller; Timothy M McPhillips; Mark A Miller; Daniel Scheibe; Jaume M Canaves; Chittibabu Guda; Lukasz Jaroszewski; Thomas L Selby; Marc-André Elsliger; John Wooley; Susan S Taylor; Keith O Hodgson; Ian A Wilson; Peter G Schultz; Raymond C Stevens
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11664-9.
2002: Pearl Akamine; Nguyen-Huu Xuong; Susan S Taylor
Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase.
Nature structural biology 2002;9(4):273-7.
2002: Fei Li; Milind Gangal; Celina Juliano; Elliot Gorfain; Susan S Taylor; David A Johnson
Evidence for an internal entropy contribution to phosphoryl transfer: a study of domain closure, backbone flexibility, and the catalytic cycle of cAMP-dependent protein kinase.
Journal of molecular biology 2002;315(3):459-69.
2002: Jaume M Canaves; Susan S Taylor
Classification and phylogenetic analysis of the cAMP-dependent protein kinase regulatory subunit family.
Journal of molecular evolution 2002;54(1):17-29.
2001: Jin Zhang; Y Ma; Susan S Taylor; Roger Y Tsien
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):14997-5002.
2001: D A Johnson; Pearl Akamine; E Radzio-Andzelm; M Madhusudan; Susan S Taylor
Dynamics of cAMP-dependent protein kinase.
Chemical reviews 2001;101(8):2243-70.
2001: L Wang; Roger K Sunahara; Andrejs M Krumins; G Perkins; M L Crochiere; M Mackey; Sean Bell; M H Ellisman; Susan S Taylor
Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3220-5.
2001: Xiaodong Cheng; Christopher Phelps; Susan S Taylor
Differential binding of cAMP-dependent protein kinase regulatory subunit isoforms Ialpha and IIbeta to the catalytic subunit.
The Journal of biological chemistry 2001;276(6):4102-8.
2001: TC Diller; Nguyen-Huu Xuong; Susan S Taylor
Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit.
Structure (London, England : 1993) 2001;9(1):73-82.
2000: F Li; Milind Gangal; J M Jones; J Deich; K E Lovett; Susan S Taylor; David A Johnson
Consequences of cAMP and catalytic-subunit binding on the flexibility of the A-kinase regulatory subunit.
Biochemistry 2000;39(50):15626-32.
2000: J M Cànaves; Darryl Leon; Susan S Taylor
Consequences of cAMP-binding site mutations on the structural stability of the type I regulatory subunit of cAMP-dependent protein kinase.
Biochemistry 2000;39(49):15022-31.
2000: TC Diller; Nguyen-Huu Xuong; Susan S Taylor
Type II beta regulatory subunit of cAMP-dependent protein kinase: purification strategies to optimize crystallization.
Protein expression and purification 2000;20(3):357-64.
2000: Poopak Banky; Marceen G Newlon; Melinda Roy; Siv Garrod; Susan S Taylor; Patricia Jennings
Isoform-specific differences between the type Ialpha and IIalpha cyclic AMP-dependent protein kinase anchoring domains revealed by solution NMR.
The Journal of biological chemistry 2000;275(45):35146-52.
2000: R T Aimes; W Hemmer; Susan S Taylor
Serine-53 at the tip of the glycine-rich loop of cAMP-dependent protein kinase: role in catalysis, P-site specificity, and interaction with inhibitors.
Biochemistry 2000;39(28):8325-32.
2000: Darryl Leon; Jaume M Canaves; Susan S Taylor
Probing the multidomain structure of the type I regulatory subunit of cAMP-dependent protein kinase using mutational analysis: role and environment of endogenous tryptophans.
Biochemistry 2000;39(19):5662-71.
1999: Milind Gangal; T Clifford; J Deich; Xiaodong Cheng; Susan S Taylor; David A Johnson
Mobilization of the A-kinase N-myristate through an isoform-specific intermolecular switch.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12394-9.
1999: Igor Tsigelny; J P Greenberg; S Cox; William Lee Nichols; Susan S Taylor; Lynn F Ten Eyck
600 ps molecular dynamics reveals stable substructures and flexible hinge points in cAMP dependent protein kinase.
Biopolymers 1999;50(5):513-24.
1999: J Setyawan; K Koide; TC Diller; M E Bunnage; Susan S Taylor; K C Nicolaou; Laurence L Brunton
Inhibition of protein kinases by balanol: specificity within the serine/threonine protein kinase subfamily.
Molecular pharmacology 1999;56(2):370-6.
1999: Lily J. Huang; Lianchun Wang; Y Ma; K Durick; G Perkins; Thomas J Deerinck; Mark H Ellisman; Susan S Taylor
NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum.
The Journal of cell biology 1999;145(5):951-9.
1999: JA Hauer; Susan S Taylor; David A Johnson
Binding-dependent disorder-order transition in PKI alpha: a fluorescence anisotropy study.
Biochemistry 1999;38(21):6774-80.
1999: Susan S Taylor; E Radzio-Andzelm; Xiaodong Cheng; Lynn F Ten Eyck; N Narayana
Catalytic subunit of cyclic AMP-dependent protein kinase: structure and dynamics of the active site cleft.
Pharmacology & therapeutics 1999;82(2-3):133-41.
1999: JA Hauer; P Barthe; Susan S Taylor; Joseph Parello; A Padilla
Two well-defined motifs in the cAMP-dependent protein kinase inhibitor (PKIalpha) correlate with inhibitory and nuclear export function.
Protein science : a publication of the Protein Society 1999;8(3):545-53.
1999: N Narayana; TC Diller; K Koide; M E Bunnage; K C Nicolaou; Laurence L Brunton; Nguyen-Huu Xuong; Lynn F Ten Eyck; Susan S Taylor
Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase.
Biochemistry 1999;38(8):2367-76.
1999: PH Hünenberger; Volkhard Helms; N Narayana; Susan S Taylor; J Andrew McCammon
Determinants of ligand binding to cAMP-dependent protein kinase.
Biochemistry 1999;38(8):2358-66.
1999: C M Smith; E Radzio-Andzelm; Pearl Akamine; Susan S Taylor
The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication.
Progress in biophysics and molecular biology 1999;71(3-4):313-41.
1998: Poopak Banky; Lily J. Huang; Susan S Taylor
Dimerization/docking domain of the type Ialpha regulatory subunit of cAMP-dependent protein kinase. Requirements for dimerization and docking are distinct but overlapping.
The Journal of biological chemistry 1998;273(52):35048-55.
1998: Jochem Struppe; Elizabeth A Komives; Susan S Taylor; Regitze R Vold
2H NMR studies of a myristoylated peptide in neutral and acidic phospholipid bicelles.
Biochemistry 1998;37(44):15523-7.
1998: N Narayana; Pearl Akamine; Nguyen-Huu Xuong; Susan S Taylor
Crystallization and preliminary X-ray analysis of the unliganded recombinant catalytic subunit of cAMP-dependent protein kinase.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 6 Pt 2):1401-4.
1998: Lily J. Huang; Susan S Taylor
Dissecting cAMP binding domain A in the RIalpha subunit of cAMP-dependent protein kinase. Distinct subsites for recognition of cAMP and the catalytic subunit.
The Journal of biological chemistry 1998;273(41):26739-46.
1998: Xiaodong Cheng; S Shaltiel; Susan S Taylor
Mapping substrate-induced conformational changes in cAMP-dependent protein kinase by protein footprinting.
Biochemistry 1998;37(40):14005-13.
1998: Milind Gangal; S Cox; J Lew; T Clifford; Siv Garrod; M Aschbaher; Susan S Taylor; David A Johnson
Backbone flexibility of five sites on the catalytic subunit of cAMP-dependent protein kinase in the open and closed conformations.
Biochemistry 1998;37(39):13728-35.
1998: Xiaodong Cheng; Y Ma; M Moore; B A Hemmings; Susan S Taylor
Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):9849-54.
1998: B D Grant; W Hemmer; I Tsigelny; J A Adams; Susan S Taylor
Kinetic analyses of mutations in the glycine-rich loop of cAMP-dependent protein kinase.
Biochemistry 1998;37(21):7708-15.
1998: K Durick; Gordon N Gill; Susan S Taylor
Shc and Enigma are both required for mitogenic signaling by Ret/ptc2.
Molecular and cellular biology 1998;18(4):2298-308.
1998: S Shaltiel; S Cox; Susan S Taylor
Conserved water molecules contribute to the extensive network of interactions at the active site of protein kinase A.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):484-91.
1997: Robin M Gibson; Susan S Taylor
Dissecting the cooperative reassociation of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Role of Trp-196 in the catalytic subunit.
The Journal of biological chemistry 1997;272(51):31998-2005.
1997: D A León; F W Herberg; Poopak Banky; Susan S Taylor
A stable alpha-helical domain at the N terminus of the RIalpha subunits of cAMP-dependent protein kinase is a novel dimerization/docking motif.
The Journal of biological chemistry 1997;272(45):28431-7.
1997: Lily J. Huang; K Durick; Joshua A Weiner; Jerold Chun; Susan S Taylor
D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11184-9.
1997: Robin M Gibson; Y Ji-Buechler; Susan S Taylor
Identification of electrostatic interaction sites between the regulatory and catalytic subunits of cyclic AMP-dependent protein kinase.
Protein science : a publication of the Protein Society 1997;6(9):1825-34.
1997: Susan S Taylor; E Radzio-Andzelm
Protein kinase inhibition: natural and synthetic variations on a theme.
Current opinion in chemical biology 1997;1(2):219-26.
1997: W Yonemoto; M L McGlone; B Grant; Susan S Taylor
Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli.
Protein engineering 1997;10(8):915-25.
1997: N Narayana; S Cox; X Nguyen-huu; Lynn F Ten Eyck; Susan S Taylor
A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility.
Structure (London, England : 1993) 1997;5(7):921-35.
1997: W Hemmer; M McGlone; Igor Tsigelny; Susan S Taylor
Role of the glycine triad in the ATP-binding site of cAMP-dependent protein kinase.
The Journal of biological chemistry 1997;272(27):16946-54.
1997: Robin M Gibson; Y Ji-Buechler; Susan S Taylor
Interaction of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Electrostatic sites on the type Ialpha regulatory subunit.
The Journal of biological chemistry 1997;272(26):16343-50.
1997: N Narayana; S Cox; S Shaltiel; Susan S Taylor; Nguyen-Huu Xuong
Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine.
Biochemistry 1997;36(15):4438-48.
1997: Lily J. Huang; K Durick; Joshua A Weiner; Jerold Chun; Susan S Taylor
Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits.
The Journal of biological chemistry 1997;272(12):8057-64.
1997: W Hemmer; M McGlone; Susan S Taylor
Recombinant strategies for rapid purification of catalytic subunits of cAMP-dependent protein kinase.
Analytical biochemistry 1997;245(2):115-22.
1997: J Lew; N Coruh; Igor Tsigelny; Siv Garrod; Susan S Taylor
Synergistic binding of nucleotides and inhibitors to cAMP-dependent protein kinase examined by acrylodan fluorescence spectroscopy.
The Journal of biological chemistry 1997;272(3):1507-13.
1996: Igor Tsigelny; B D Grant; Susan S Taylor; Lynn F Ten Eyck
Catalytic subunit of cAMP-dependent protein kinase: electrostatic features and peptide recognition.
Biopolymers 1996;39(3):353-65.
1996: R Wu; K Durick; Zhou Songyang; L C Cantley; Susan S Taylor; Gordon N Gill
Specificity of LIM domain interactions with receptor tyrosine kinases.
The Journal of biological chemistry 1996;271(27):15934-41.
1996: B D Grant; Igor Tsigelny; JA Adams; Susan S Taylor
Examination of an active-site electrostatic node in the cAMP-dependent protein kinase catalytic subunit.
Protein science : a publication of the Protein Society 1996;5(7):1316-24.
1996: K Durick; R Y Wu; Gordon N Gill; Susan S Taylor
Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain.
The Journal of biological chemistry 1996;271(22):12691-4.
1996: F W Herberg; Susan S Taylor; W R Dostmann
Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase.
Biochemistry 1996;35(9):2934-42.
1995: S Cox; Susan S Taylor
Kinetic analysis of cAMP-dependent protein kinase: mutations at histidine 87 affect peptide binding and pH dependence.
Biochemistry 1995;34(49):16203-9.
1995: K Durick; V J Yao; Maria Grazia Borrello; Italia Bongarzone; M A Pierotti; Susan S Taylor
Tyrosines outside the kinase core and dimerization are required for the mitogenic activity of RET/ptc2.
The Journal of biological chemistry 1995;270(42):24642-5.
1995: Susan S Taylor; E Radzio-Andzelm; Tony Hunter
How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(13):1255-66.
1995: K Koide; M E Bunnage; L Gomez Paloma; Joan R Kanter; Susan S Taylor; Laurence L Brunton; Kyriacos C Nicolaou
Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol.
Chemistry & biology 1995;2(9):601-8.
1995: Y Su; W R Dostmann; F W Herberg; K Durick; Nguyen-Huu Xuong; Lynn F Ten Eyck; Susan S Taylor; Kottayil I Varughese
Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains.
Science (New York, N.Y.) 1995;269(5225):807-13.
1995: W Wen; Judy L Meinkoth; Roger Y Tsien; Susan S Taylor
Identification of a signal for rapid export of proteins from the nucleus.
Cell 1995;82(3):463-73.
1995: JA Adams; M L McGlone; R Gibson; Susan S Taylor
Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase.
Biochemistry 1995;34(8):2447-54.
1995: W Wen; Susan S Taylor; Judy L Meinkoth
The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated.
The Journal of biological chemistry 1995;270(5):2041-6.
1994: W Wen; A T Harootunian; S R Adams; James R Feramisco; Roger Y Tsien; Judy L Meinkoth; Susan S Taylor
Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal.
The Journal of biological chemistry 1994;269(51):32214-20.
1994: S Cox; E Radzio-Andzelm; Susan S Taylor
Domain movements in protein kinases.
Current opinion in structural biology 1994;4(6):893-901.
1994: S Cox; Susan S Taylor
Holoenzyme interaction sites in the cAMP-dependent protein kinase. Histidine 87 in the catalytic subunit complements serine 99 in the type I regulatory subunit.
The Journal of biological chemistry 1994;269(36):22614-22.
1994: R Karlsson; Susan S Taylor; J M Sowadski
Intermolecular contacts in various crystal forms related to the open and closed conformational states of the catalytic subunit of cAMP-dependent protein kinase.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 4):657-62.
1994: F W Herberg; W R Dostmann; M Zorn; S J Davis; Susan S Taylor
Crosstalk between domains in the regulatory subunit of cAMP-dependent protein kinase: influence of amino terminus on cAMP binding and holoenzyme formation.
Biochemistry 1994;33(23):7485-94.
1994: Susan S Taylor; E Radzio-Andzelm
Three protein kinase structures define a common motif.
Structure (London, England : 1993) 1994;2(5):345-55.
1994: E A Trafny; Nguyen-Huu Xuong; J A Adams; Lynn F Ten Eyck; Susan S Taylor; J M Sowadski
cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer.
Protein science : a publication of the Protein Society 1994;3(2):176-87.
1994: D A Fantozzi; A T Harootunian; W Wen; Susan S Taylor; James R Feramisco; Roger Y Tsien; Judy L Meinkoth
Thermostable inhibitor of cAMP-dependent protein kinase enhances the rate of export of the kinase catalytic subunit from the nucleus.
The Journal of biological chemistry 1994;269(4):2676-86.
1993: F W Herberg; Susan S Taylor
Physiological inhibitors of the catalytic subunit of cAMP-dependent protein kinase: effect of MgATP on protein-protein interactions.
Biochemistry 1993;32(50):14015-22.
1993: JA Adams; Susan S Taylor
Divalent metal ions influence catalysis and active-site accessibility in the cAMP-dependent protein kinase.
Protein science : a publication of the Protein Society 1993;2(12):2177-86.
1993: M Veron; E Radzio-Andzelm; Igor Tsigelny; Lynn F Ten Eyck; Susan S Taylor
A conserved helix motif complements the protein kinase core.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10618-22.
1993: Judy L Meinkoth; ARTHUR S ALBERTS; W Went; D Fantozzi; Susan S Taylor; M Hagiwara; M Montminy; James R Feramisco
Signal transduction through the cAMP-dependent protein kinase.
Molecular and cellular biochemistry 1993;127-128():179-86.
1993: A T Harootunian; S R Adams; W Wen; Judy L Meinkoth; Susan S Taylor; Roger Y Tsien
Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion.
Molecular biology of the cell 1993;4(10):993-1002.
1993: J Zheng; D R Knighton; Nguyen-Huu Xuong; Susan S Taylor; J M Sowadski; Lynn F Ten Eyck
Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations.
Protein science : a publication of the Protein Society 1993;2(10):1559-73.
1993: W Yonemoto; S M Garrod; Sean Bell; Susan S Taylor
Identification of phosphorylation sites in the recombinant catalytic subunit of cAMP-dependent protein kinase.
The Journal of biological chemistry 1993;268(25):18626-32.
1993: F W Herberg; Sean Bell; Susan S Taylor
Expression of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli: multiple isozymes reflect different phosphorylation states.
Protein engineering 1993;6(7):771-7.
1993: Y J Buechler; F W Herberg; Susan S Taylor
Regulation-defective mutants of type I cAMP-dependent protein kinase. Consequences of replacing arginine 94 and arginine 95.
The Journal of biological chemistry 1993;268(22):16495-503.
1993: M J Marcote; D R Knighton; G Basi; J M Sowadski; P Brambilla; G Draetta; Susan S Taylor
A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites.
Molecular and cellular biology 1993;13(8):5122-31.
1993: R Karlsson; J Zheng; Nguyen-Huu Xuong; Susan S Taylor; J M Sowadski
Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation.
Acta crystallographica. Section D, Biological crystallography 1993;49(Pt 4):381-8.
1993: Susan S Taylor; J Zheng; E Radzio-Andzelm; D R Knighton; Lynn F Ten Eyck; J M Sowadski; F W Herberg; W M Yonemoto
cAMP-dependent protein kinase defines a family of enzymes.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;340(1293):315-24.
1993: D R Knighton; D L Cadena; J Zheng; Lynn F Ten Eyck; Susan S Taylor; J M Sowadski; Gordon N Gill
Structural features that specify tyrosine kinase activity deduced from homology modeling of the epidermal growth factor receptor.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5001-5.
1993: J Zheng; E A Trafny; D R Knighton; Nguyen-Huu Xuong; Susan S Taylor; Lynn F Ten Eyck; J M Sowadski
2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor.
Acta crystallographica. Section D, Biological crystallography 1993;49(Pt 3):362-5.
1993: D R Knighton; Sean Bell; J Zheng; Lynn F Ten Eyck; Nguyen-Huu Xuong; Susan S Taylor; J M Sowadski
2.0 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent.
Acta crystallographica. Section D, Biological crystallography 1993;49(Pt 3):357-61.
1993: J A Adams; Susan S Taylor
Phosphorylation of peptide substrates for the catalytic subunit of cAMP-dependent protein kinase.
The Journal of biological chemistry 1993;268(11):7747-52.
1993: Y Su; Susan S Taylor; W R Dostmann; Nguyen-Huu Xuong; Kottayil I Varughese
Crystallization of a deletion mutant of the R-subunit of cAMP dependent protein kinase.
Journal of molecular biology 1993;230(3):1091-3.
1993: J Zheng; D R Knighton; Lynn F Ten Eyck; R Karlsson; Nguyen-Huu Xuong; Susan S Taylor; J M Sowadski
Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor.
Biochemistry 1993;32(9):2154-61.
1993: W Yonemoto; M L McGlone; Susan S Taylor
N-myristylation of the catalytic subunit of cAMP-dependent protein kinase conveys structural stability.
The Journal of biological chemistry 1993;268(4):2348-52.
1993: S Adams; Brian J Bacskai; A T Harootunian; M Mahaut-Smith; P J Sammak; Susan S Taylor; Roger Y Tsien
Imaging of cAMP signals and A-kinase translocation in single living cells.
Advances in second messenger and phosphoprotein research 1993;28():167-70.
1993: Susan S Taylor; E Radzio-Andzelm; D R Knighton; Lynn F Ten Eyck; J M Sowadski; F W Herberg; W Yonemoto; J Zheng
Crystal structures of the catalytic subunit of cAMP-dependent protein kinase reveal general features of the protein kinase family.
Receptor 1993;3(3):165-72.
1992: J Toner-Webb; S M van Patten; D A Walsh; Susan S Taylor
Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase.
The Journal of biological chemistry 1992;267(35):25174-80.
1992: S K Mann; W M Yonemoto; Susan S Taylor; Richard A Firtel
DdPK3, which plays essential roles during Dictyostelium development, encodes the catalytic subunit of cAMP-dependent protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10701-5.
1992: D R Knighton; R B Pearson; J M Sowadski; A R Means; Lynn F Ten Eyck; Susan S Taylor; B E Kemp
Structural basis of the intrasteric regulation of myosin light chain kinases.
Science (New York, N.Y.) 1992;258(5079):130-5.
1992: JA Adams; Susan S Taylor
Energetic limits of phosphotransfer in the catalytic subunit of cAMP-dependent protein kinase as measured by viscosity experiments.
Biochemistry 1992;31(36):8516-22.
1992: D A Fantozzi; Susan S Taylor; Paul W Howard; Richard A Maurer; James R Feramisco; Judy L Meinkoth
Effect of the thermostable protein kinase inhibitor on intracellular localization of the catalytic subunit of cAMP-dependent protein kinase.
The Journal of biological chemistry 1992;267(24):16824-8.
1992: J H Zheng; D R Knighton; Nguyen-Huu Xuong; Joseph Parello; Susan S Taylor; J M Sowadski
Crystallization studies of the catalytic subunit of cAMP-dependent protein kinase: crystals of murine recombinant catalytic subunit and a mutant, Cys 343----Ser, diffract to 2.7 A resolution.
Acta crystallographica. Section B, Structural science 1992;48 ( Pt 2)():241-4.
1992: Susan S Taylor; D R Knighton; J Zheng; Lynn F Ten Eyck; J M Sowadski
Structural framework for the protein kinase family.
Annual review of cell biology 1992;8():429-62.
1992: Susan S Taylor; D R Knighton; J Zheng; Lynn F Ten Eyck; J M Sowadski
cAMP-dependent protein kinase and the protein kinase family.
Faraday discussions 1992;(93):143-52.
1991: W R Dostmann; Susan S Taylor
Identifying the molecular switches that determine whether (Rp)-cAMPS functions as an antagonist or an agonist in the activation of cAMP-dependent protein kinase I.
Biochemistry 1991;30(35):8710-6.
1991: D R Knighton; J H Zheng; Lynn F Ten Eyck; Nguyen-Huu Xuong; Susan S Taylor; J M Sowadski
Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.
Science (New York, N.Y.) 1991;253(5018):414-20.
1991: D R Knighton; J H Zheng; Lynn F Ten Eyck; V A Ashford; Nguyen-Huu Xuong; Susan S Taylor; J M Sowadski
Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.
Science (New York, N.Y.) 1991;253(5018):407-14.
1991: D R Knighton; Nguyen-Huu Xuong; Susan S Taylor; J M Sowadski
Crystallization studies of cAMP-dependent protein kinase. Cocrystals of the catalytic subunit with a 20 amino acid residue peptide inhibitor and MgATP diffract to 3.0 A resolution.
Journal of molecular biology 1991;220(2):217-20.
1991: D A León; W R Dostmann; Susan S Taylor
Unfolding of the regulatory subunit of cAMP-dependent protein kinase I.
Biochemistry 1991;30(12):3035-40.
1991: Y J Buechler; Susan S Taylor
Mutations in the autoinhibitor site of the regulatory subunit of cAMP-dependent protein kinase I. Replacement of Ala-97 and Ser-99 interferes with reassociation with the catalytic subunit.
The Journal of biological chemistry 1991;266(6):3491-7.
1991: S R Adams; A T Harootunian; Y J Buechler; Susan S Taylor; Roger Y Tsien
Fluorescence ratio imaging of cyclic AMP in single cells.
Nature 1991;349(6311):694-7.
1991: J J Neitzel; W R Dostmann; Susan S Taylor
Role of MgATP in the activation and reassociation of cAMP-dependent protein kinase I: consequences of replacing the essential arginine in cAMP binding site A.
Biochemistry 1991;30(3):733-9.
1991: W M Yonemoto; M L McGlone; L W Slice; Susan S Taylor
Prokaryotic expression of catalytic subunit of adenosine cyclic monophosphate-dependent protein kinase.
Methods in enzymology 1991;200():581-96.
1991: J H Zheng; D R Knighton; Joseph Parello; Susan S Taylor; J M Sowadski
Crystallization of catalytic subunit of adenosine cyclic monophosphate-dependent protein kinase.
Methods in enzymology 1991;200():508-21.
1991: J A Buechler; J A Toner-Webb; Susan S Taylor
Carbodiimides as probes for protein kinase structure and function.
Methods in enzymology 1991;200():487-500.
1990: J L Meinkoth; Y Ji; Susan S Taylor; James R Feramisco
Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9595-9.
1990: G E Ringheim; Susan S Taylor
Effects of cAMP-binding site mutations on intradomain cross-communication in the regulatory subunit of cAMP-dependent protein kinase I.
The Journal of biological chemistry 1990;265(32):19472-8.
1990: W R Dostmann; Susan S Taylor; Hans-Gottfried Genieser; B Jastorff; Stein Ove Døskeland; D Ogreid
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates.
The Journal of biological chemistry 1990;265(18):10484-91.
1990: G E Ringheim; Susan S Taylor
Dissecting the domain structure of the regulatory subunit of cAMP-dependent protein kinase I and elucidating the role of MgATP.
The Journal of biological chemistry 1990;265(9):4800-8.
1990: J A Buechler; Susan S Taylor
Differential labeling of the catalytic subunit of cAMP-dependent protein kinase with a water-soluble carbodiimide: identification of carboxyl groups protected by MgATP and inhibitor peptides.
Biochemistry 1990;29(7):1937-43.
1990: Robert J Duronio; E Jackson-Machelski; Robert O. Heuckeroth; P O Olins; C S Devine; W Yonemoto; L W Slice; Susan S Taylor; Jeffrey I Gordon
Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(4):1506-10.
1990: D Ogreid; Susan S Taylor
Expression and characterization of a truncated form of regulatory subunit of cAMP-dependent protein kinase I lacking binding domain A.
Advances in second messenger and phosphoprotein research 1990;24():196-201.
1990: Susan S Taylor; J A Buechler; W Yonemoto
cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.
Annual review of biochemistry 1990;59():971-1005.
1989: L W Slice; Susan S Taylor
Expression of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli.
The Journal of biological chemistry 1989;264(35):20940-6.
1989: S Durgerian; Susan S Taylor
The consequences of introducing an autophosphorylation site into the type I regulatory subunit of cAMP-dependent protein kinase.
The Journal of biological chemistry 1989;264(17):9807-13.
1989: Susan S Taylor
cAMP-dependent protein kinase. Model for an enzyme family.
The Journal of biological chemistry 1989;264(15):8443-6.
1989: E A First; D A Johnson; Susan S Taylor
Fluorescence energy transfer between cysteine 199 and cysteine 343: evidence for MgATP-dependent conformational change in the catalytic subunit of cAMP-dependent protein kinase.
Biochemistry 1989;28(8):3606-13.
1989: E A First; Susan S Taylor
Selective modification of the catalytic subunit of cAMP-dependent protein kinase with sulfhydryl-specific fluorescent probes.
Biochemistry 1989;28(8):3598-605.
1989: J A Buechler; Thomas Vedvick; Susan S Taylor
Differential labeling of the catalytic subunit of cAMP-dependent protein kinase with acetic anhydride: substrate-induced conformational changes.
Biochemistry 1989;28(7):3018-24.
1989: J A Buechler; Susan S Taylor
Dicyclohexylcarbodiimide cross-links two conserved residues, Asp-184 and Lys-72, at the active site of the catalytic subunit of cAMP-dependent protein kinase.
Biochemistry 1989;28(5):2065-70.
1988: G E Ringheim; L D Saraswat; J Bubis; Susan S Taylor
Deletion of cAMP-binding site B in the regulatory subunit of cAMP-dependent protein kinase alters the photoaffinity labeling of site A.
The Journal of biological chemistry 1988;263(34):18247-52.
1988: L D Saraswat; G E Ringheim; J Bubis; Susan S Taylor
Deletion mutants as probes for localizing regions of subunit interaction in cAMP-dependent protein kinase.
The Journal of biological chemistry 1988;263(34):18241-6.
1988: J A Buechler; Susan S Taylor
Identification of aspartate-184 as an essential residue in the catalytic subunit of cAMP-dependent protein kinase.
Biochemistry 1988;27(19):7356-61.
1988: Susan S Taylor; J Bubis; J Toner-Webb; L D Saraswat; E A First; J A Buechler; D R Knighton; J Sowadski
CAMP-dependent protein kinase: prototype for a family of enzymes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1988;2(11):2677-85.
1988: J Bubis; J J Neitzel; L D Saraswat; Susan S Taylor
A point mutation abolishes binding of cAMP to site A in the regulatory subunit of cAMP-dependent protein kinase.
The Journal of biological chemistry 1988;263(20):9668-73.
1988: E A First; J Bubis; Susan S Taylor
Subunit interaction sites between the regulatory and catalytic subunits of cAMP-dependent protein kinase. Identification of a specific interchain disulfide bond.
The Journal of biological chemistry 1988;263(11):5176-82.
1988: E A First; Susan S Taylor
Subunit interaction sites between the regulatory and catalytic subunits of cAMP-dependent protein kinase. Heterobifunctional cross-linking reagents lead to photodependent and photoindependent cross-linking.
The Journal of biological chemistry 1988;263(11):5170-5.
1988: J Bubis; L D Saraswat; Susan S Taylor
Tyrosine-371 contributes to the positive cooperativity between the two cAMP binding sites in the regulatory subunit of cAMP-dependent protein kinase I.
Biochemistry 1988;27(5):1570-6.
1988: G Gibney; K MacPhee-Quigley; B Thompson; Thomas Vedvick; M G Low; Susan S Taylor; Palmer Taylor
Divergence in primary structure between the molecular forms of acetylcholinesterase.
The Journal of biological chemistry 1988;263(3):1140-5.
1988: Susan S Taylor; J A Buechler; L W Slice; D K Knighton; S Durgerian; G E Ringheim; J J Neitzel; W M Yonemoto; J M Sowadski; W Dospmann
cAMP-dependent protein kinase: a framework for a diverse family of enzymes.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():121-30.
1987: J Toner-Webb; Susan S Taylor
Inhibition of the catalytic subunit of cAMP-dependent protein kinase by dicyclohexylcarbodiimide.
Biochemistry 1987;26(23):7371-8.
1987: J Bubis; Thomas Vedvick; Susan S Taylor
Antiparallel alignment of the two protomers of the regulatory subunit dimer of cAMP-dependent protein kinase I.
The Journal of biological chemistry 1987;262(31):14961-6.
1987: J Bubis; Susan S Taylor
Limited proteolysis alters the photoaffinity labeling of adenosine 3',5'-monophosphate dependent protein kinase II with 8-azidoadenosine 3',5'-monophosphate.
Biochemistry 1987;26(19):5997-6004.
1987: J Bubis; Susan S Taylor
Correlation of photolabeling with occupancy of cAMP binding sites in the regulatory subunit of cAMP-dependent protein kinase I.
Biochemistry 1987;26(12):3478-86.
1986: M Schumacher; Shelley Camp; Y Maulet; M Newton; K MacPhee-Quigley; Susan S Taylor; T Friedmann; Palmer Taylor
Primary structure of acetylcholinesterase: implications for regulation and function.
Federation proceedings 1986;45(13):2976-81.
1986: M Schumacher; Shelley Camp; Y Maulet; M Newton; K MacPhee-Quigley; Susan S Taylor; T Friedmann; Palmer Taylor
Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence.
Nature 1986;319(6052):407-9.
1986: Susan S Taylor; L D Saraswat; J A Toner; J Bubis
The relationship between structure and function in cAMP-dependent protein kinases.
Annals of the New York Academy of Sciences 1986;478():191-202.