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Claudia Temperini

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Francesco Mincione; Francesca Benedini; Stefano Biondi; Alessandro Cecchi; Claudia Temperini; Giuseppe Formicola; Ilaria Pacileo; Andrea Scozzafava; Emanuela Masini; Claudiu T Supuran
Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.
Khyati Dave; Marc A Ilies; Andrea Scozzafava; Claudia Temperini; Daniela Vullo; Claudiu T Supuran
An inhibitor-like binding mode of a carbonic anhydrase activator within the active site of isoform II.
Angela Casini; Claudia Temperini; Chiara Gabbiani; Claudiu T Supuran; Luigi Messori
The x-ray structure of the adduct between NAMI-A and carbonic anhydrase provides insights into the reactivity of this metallodrug with proteins.

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All Publications

2011: Francesco Mincione; Francesca Benedini; Stefano Biondi; Alessandro Cecchi; Claudia Temperini; Giuseppe Formicola; Ilaria Pacileo; Andrea Scozzafava; Emanuela Masini; Claudiu T Supuran
Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.
Bioorganic & medicinal chemistry letters 2011;21(11):3216-21.
2011: Khyati Dave; Marc A Ilies; Andrea Scozzafava; Claudia Temperini; Daniela Vullo; Claudiu T Supuran
An inhibitor-like binding mode of a carbonic anhydrase activator within the active site of isoform II.
Bioorganic & medicinal chemistry letters 2011;21(9):2764-8.
2010: Angela Casini; Claudia Temperini; Chiara Gabbiani; Claudiu T Supuran; Luigi Messori
The x-ray structure of the adduct between NAMI-A and carbonic anhydrase provides insights into the reactivity of this metallodrug with proteins.
ChemMedChem 2010;5(12):1989-94.
2010: Fabrizio Carta; Claudia Temperini; Alessio Innocenti; Andrea Scozzafava; Kai Kaila; Claudiu T Supuran
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.
Journal of medicinal chemistry 2010;53(15):5511-22.
2010: Claudia Temperini; Alessio Innocenti; Andrea Scozzafava; Seppo Parkkila; Claudiu T Supuran
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.
Journal of medicinal chemistry 2010;53(2):850-4.
2010: Claudia Temperini; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II-trithiocarbonate adduct--an inhibitor mimicking the sulfonamide and urea binding to the enzyme.
Bioorganic & medicinal chemistry letters 2010;20(2):474-8.
2009: Alfonso Maresca; Claudia Temperini; Hoan Vu; Ngoc B Pham; Sally-Ann Poulsen; Andrea Scozzafava; Ronald J Quinn; Claudiu T Supuran
Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.
Journal of the American Chemical Society 2009;131(8):3057-62.
2009: Letizia Crocetti; Alfonso Maresca; Claudia Temperini; Rebecca A Hall; Andrea Scozzafava; Fritz A Mühlschlegel; Claudiu T Supuran
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.
Bioorganic & medicinal chemistry letters 2009;19(5):1371-5.
2009: Claudia Temperini; Alessandro Cecchi; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.
Bioorganic & medicinal chemistry 2009;17(3):1214-21.
2009: Claudia Temperini; Alessandro Cecchi; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.
Journal of medicinal chemistry 2009;52(2):322-8.
2008: Claudia Temperini; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
Bioorganic & medicinal chemistry 2008;16(18):8373-8.
2008: Claudia Temperini; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2008;18(15):4282-6.
2008: Claudia Temperini; Alessandro Cecchi; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited--old leads for new applications?
Organic & biomolecular chemistry 2008;6(14):2499-506.
2008: Claudia Temperini; Alessandro Cecchi; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.
Bioorganic & medicinal chemistry letters 2008;18(8):2567-73.
2008: Franciszek Saczewski; Alessio Innocenti; Jarosław Sławiński; Anita Kornicka; Zdzislaw Brzozowski; Elzbieta Pomarnacka; Andrea Scozzafava; Claudia Temperini; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.
Bioorganic & medicinal chemistry 2008;16(7):3933-40.
2008: Claudia Temperini; Alessandro Cecchi; Nicholas A Boyle; Andrea Scozzafava; Jaime Escribano Cabeza; Paul Wentworth; G Michael Blackburn; Claudiu T Supuran
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2008;18(3):999-1005.
2008: Claudia Temperini; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activation and the drug design.
Current pharmaceutical design 2008;14(7):708-15.
2008: Ozlen Güzel; Claudia Temperini; Alessio Innocenti; Andrea Scozzafava; Aydin Salman; Claudiu T Supuran
Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2008;18(1):152-8.
2007: Anna Ohradanova; Daniela Vullo; Juraj Kopacek; Claudia Temperini; Tatiana Betakova; Silvia Pastorekova; Jaromir Pastorek; Claudiu T Supuran
Reconstitution of carbonic anhydrase activity of the cell-surface-binding protein of vaccinia virus.
The Biochemical journal 2007;407(1):61-7.
2007: Claudia Temperini; Alessio Innocenti; Antonio Mastrolorenzo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2007;17(17):4866-72.
2007: Claudia Temperini; Jean-Yves Winum; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(10):2795-801.
2007: Claudia Temperini; Alessio Innocenti; Annalisa Guerri; Andrea Scozzafava; Stefano Rusconi; Claudiu T Supuran
Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.
Bioorganic & medicinal chemistry letters 2007;17(8):2210-5.
2007: Claudia Temperini; Alessio Innocenti; Andrea Scozzafava; Antonio Mastrolorenzo; Claudiu T Supuran
Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.
Bioorganic & medicinal chemistry letters 2007;17(3):628-35.
2007: Angela Casini; Guido Mastrobuoni; Claudia Temperini; Chiara Gabbiani; Simona Francese; Gloriano Moneti; Claudiu T Supuran; Andrea Scozzafava; Luigi Messori
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme.
Chemical communications (Cambridge, England) 2007;(2):156-8.
2006: Jean-Yves Winum; Claudia Temperini; Khaled El Cheikh; Alessio Innocenti; Daniela Vullo; Samuele Ciattini; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.
Journal of medicinal chemistry 2006;49(24):7024-31.
2006: Claudia Temperini; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I.
Bioorganic & medicinal chemistry letters 2006;16(19):5152-6.
2006: Claudia Temperini; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(27):7057-66.
2006: Claudia Temperini; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(16):4316-20.
2006: Claudia Temperini; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design.
Journal of medicinal chemistry 2006;49(10):3019-27.
2005: Claudia Temperini; Andrea Scozzafava; Luca Puccetti; Claudiu T Supuran
Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators.
Bioorganic & medicinal chemistry letters 2005;15(23):5136-41.
2005: Claudia Temperini; Maurizio Cirilli; Massimiliano Aschi; Giovanni Ughetto
Role of the amino sugar in the DNA binding of disaccharide anthracyclines: crystal structure of the complex MAR70/d(CGATCG).
Bioorganic & medicinal chemistry 2005;13(5):1673-9.
2003: Claudia Temperini; Luigi Messori; Pierluigi Orioli; Cristina Di Bugno; Fabio Animati; Giovanni Ughetto
The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes.
Nucleic acids research 2003;31(5):1464-9.
2002: Anna Rita Bilia; Diamanto Lazari; Luigi Messori; Vania Taglioli; Claudia Temperini; Franco Francesco Vincieri
Simple and rapid physico-chemical methods to examine action of antimalarial drugs with hemin: its application to Artemisia annua constituents.
Life sciences 2002;70(7):769-78.
2001: Luigi Messori; Claudia Temperini; Francesca Piccioli; Fabio Animati; Cristina Di Bugno; Pierluigi Orioli
Solution chemistry and DNA binding properties of MEN 10755, a novel disaccharide analogue of doxorubicin.
Bioorganic & medicinal chemistry 2001;9(7):1815-25.