Peter ten Dijke

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Chemicals & Drugs

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Naber H P H; ten Dijke P; Pardali E
Role of TGF-beta in the tumor stroma.
Pannu Jaspreet; Asano Yoshihide; Nakerakanti Sashidhar; Smith Edwin; Jablonska Stefania; Blaszczyk Maria; ten Dijke Peter; Trojanowska Maria
Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate.
Finnson Kenneth W; Parker Wendy L; ten Dijke Peter; Thorikay Midory; Philip Anie
ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes.

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All Publications

2008: Naber H P H; ten Dijke P; Pardali E
Role of TGF-beta in the tumor stroma.
Current cancer drug targets 2008;8(6):466-72.
2008: Pannu Jaspreet; Asano Yoshihide; Nakerakanti Sashidhar; Smith Edwin; Jablonska Stefania; Blaszczyk Maria; ten Dijke Peter; Trojanowska Maria
Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate.
Arthritis and rheumatism 2008;58(8):2528-37.
2008: Finnson Kenneth W; Parker Wendy L; ten Dijke Peter; Thorikay Midory; Philip Anie
ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008;23(6):896-906.
2008: Kodach Liudmila L; Wiercinska Eliza; de Miranda Noel F C C; Bleuming Sylvia A; Musler Alex R; Peppelenbosch Maikel P; Dekker Evelien; van den Brink Gijs R; van Noesel Carel J M; Morreau Hans; Hommes Daniel W; Ten Dijke Peter; Offerhaus G Johan A; Hardwick James C H
The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers.
Gastroenterology 2008;134(5):1332-41.
2008: Rudini Noemi; Felici Angelina; Giampietro Costanza; Lampugnani MariaGrazia; Corada Monica; Swirsding Kendra; Garrè Massimiliano; Liebner Stefan; Letarte Michelle; ten Dijke Peter; Dejana Elisabetta
VE-cadherin is a critical endothelial regulator of TGF-beta signalling.
The EMBO journal 2008;27(7):993-1004.
2008: Monteiro Rui; van Dinther Maarten; Bakkers Jeroen; Wilkinson Robert; Patient Roger; ten Dijke Peter; Mummery Christine
Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish.
Developmental biology 2008;315(1):55-71.
2008: Petersen M; Thorikay M; Deckers M; van Dinther M; Grygielko E T; Gellibert F; de Gouville A C; Huet S; ten Dijke P; Laping N J
Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis.
Kidney international 2008;73(6):705-15.
2008: ten Dijke Peter; Krause Carola; de Gorter David J J; Löwik Clemens W G M; van Bezooijen Rutger L
Osteocyte-derived sclerostin inhibits bone formation: its role in bone morphogenetic protein and Wnt signaling.
The Journal of bone and joint surgery. American volume 2008;90 Suppl 1():31-5.
2008: ten Dijke Peter; Goumans Marie-José; Pardali Evangelia
Endoglin in angiogenesis and vascular diseases.
Angiogenesis 2008;11(1):79-89.
2007: Carvalho Rita L C; Itoh Fumiko; Goumans Marie-Jose; Lebrin Franck; Kato Mitsuyasu; Takahashi Satoru; Ema Masatsugu; Itoh Susumu; van Rooijen Marga; Bertolino Philippe; Ten Dijke Peter; Mummery Christine L
Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice.
Journal of cell science 2007;120(Pt 24):4269-77.
2007: ten Dijke Peter; Arthur Helen M
Extracellular control of TGFbeta signalling in vascular development and disease.
Nature reviews. Molecular cell biology 2007;8(11):857-69.
2007: Buijs Jeroen T; Henriquez Nico V; van Overveld Petra G M; van der Horst Geertje; Que Ivo; Schwaninger Ruth; Rentsch Cyrill; Ten Dijke Peter; Cleton-Jansen Anne-Marie; Driouch Keltouma; Lidereau Rosette; Bachelier Richard; Vukicevic Slobodan; Clézardin Philippe; Papapoulos Socrates E; Cecchini Marco G; Löwik Clemens W G M; van der Pluijm Gabri
Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer.
Cancer research 2007;67(18):8742-51.
2007: Buijs Jeroen T; Rentsch Cyrill A; van der Horst Geertje; van Overveld Petra G M; Wetterwald Antoinette; Schwaninger Ruth; Henriquez Niek V; Ten Dijke Peter; Borovecki Fran; Markwalder Regula; Thalmann George N; Papapoulos Socrates E; Pelger Rob C M; Vukicevic Slobodan; Cecchini Marco G; Löwik Clemens W G M; van der Pluijm Gabri
BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo.
The American journal of pathology 2007;171(3):1047-57.
2007: Dennler Sylviane; André Jocelyne; Alexaki Ismini; Li Allen; Magnaldo Thierry; ten Dijke Peter; Wang Xiao-Jing; Verrecchia Franck; Mauviel Alain
Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo.
Cancer research 2007;67(14):6981-6.
2007: Castañares Cristina; Redondo-Horcajo Mariano; Magán-Marchal Noemi; ten Dijke Peter; Lamas Santiago; Rodríguez-Pascual Fernando
Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferation.
Journal of cell science 2007;120(Pt 7):1256-66.
2007: Pannu Jaspreet; Nakerakanti Sashidhar; Smith Edwin; ten Dijke Peter; Trojanowska Maria
Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways.
The Journal of biological chemistry 2007;282(14):10405-13.
2007: Itoh Susumu; ten Dijke Peter
Negative regulation of TGF-beta receptor/Smad signal transduction.
Current opinion in cell biology 2007;19(2):176-84.
2007: Scharpfenecker Marion; van Dinther Maarten; Liu Zhen; van Bezooijen Rutger L; Zhao Qinghai; Pukac Laurie; Löwik Clemens W G M; ten Dijke P
BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis.
Journal of cell science 2007;120(Pt 6):964-72.
2007: Li Yina; Litingtung Ying; Ten Dijke Peter; Chiang Chin
Aberrant Bmp signaling and notochord delamination in the pathogenesis of esophageal atresia.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(3):746-54.
2007: Boon Reinier A; Fledderus Joost O; Volger Oscar L; van Wanrooij Eva J A; Pardali Evangelia; Weesie Frank; Kuiper Johan; Pannekoek Hans; ten Dijke Peter; Horrevoets Anton J G
KLF2 suppresses TGF-beta signaling in endothelium through induction of Smad7 and inhibition of AP-1.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(3):532-9.
2007: van Bezooijen Rutger L; Deruiter Marco C; Vilain Nathalie; Monteiro Rui M; Visser Annemieke; van der Wee-Pals Lianne; van Munsteren Conny J; Hogendoorn Pancras C W; Aguet Michel; Mummery Christine L; Papapoulos Socrates E; Ten Dijke Peter; Löwik Clemens W G M
SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(2):606-12.
2007: van Bezooijen Rutger L; Svensson J Peter; Eefting Daniël; Visser Annemieke; van der Horst Geertje; Karperien Marcel; Quax Paul H A; Vrieling Harry; Papapoulos Socrates E; ten Dijke Peter; Löwik Clemens W G M
Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(1):19-28.
2007: Buijs Jeroen T; Henriquez Niek V; van Overveld Petra G M; van der Horst Geertje; ten Dijke Peter; van der Pluijm Gabri
TGF-beta and BMP7 interactions in tumour progression and bone metastasis.
Clinical & experimental metastasis 2007;24(8):609-17.
2007: Zilberberg Lior; ten Dijke Peter; Sakai Lynn Y; Rifkin Daniel B
A rapid and sensitive bioassay to measure bone morphogenetic protein activity.
BMC cell biology 2007;8():41.
2006: Inamitsu Masako; Itoh Susumu; Hellman Ulf; Ten Dijke Peter; Kato Mitsuyasu
Methylation of Smad6 by protein arginine N-methyltransferase 1.
FEBS letters 2006;580(28-29):6603-11.
2006: Melke Pontus; Jönsson Henrik; Pardali Evangelia; ten Dijke Peter; Peterson Carsten
A rate equation approach to elucidate the kinetics and robustness of the TGF-beta pathway.
Biophysical journal 2006;91(12):4368-80.
2006: van Laake Linda W; van den Driesche Sander; Post Simone; Feijen Alie; Jansen Maurits A; Driessens Mariette H; Mager Johannes J; Snijder Repke J; Westermann Cornelius J J; Doevendans Pieter A; van Echteld Cees J A; ten Dijke Peter; Arthur Helen M; Goumans Marie-José; Lebrin Franck; Mummery Christine L
Endoglin has a crucial role in blood cell-mediated vascular repair.
Circulation 2006;114(21):2288-97.
2006: Han Gangwen; Li Allen G; Liang Yao-Yun; Owens Philip; He Wei; Lu Shilong; Yoshimatsu Yasuhiro; Wang Donna; Ten Dijke Peter; Lin Xia; Wang Xiao-Jing
Smad7-induced beta-catenin degradation alters epidermal appendage development.
Developmental cell 2006;11(3):301-12.
2006: Noda D; Itoh S; Watanabe Y; Inamitsu M; Dennler S; Itoh F; Koike S; Danielpour D; ten Dijke P; Kato M
ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrest of prostate cells.
Oncogene 2006;25(41):5591-600.
2006: Wiercinska Eliza; Wickert Lucia; Denecke Bernd; Said Harun M; Hamzavi Jafar; Gressner A M; Thorikay Midori; ten Dijke Peter; Mertens Peter R; Breitkopf Katja; Dooley Steven
Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells.
Hepatology (Baltimore, Md.) 2006;43(5):1032-41.
2006: Deckers Martine; van Dinther Maarten; Buijs Jeroen; Que Ivo; Löwik Clemens; van der Pluijm Gabri; ten Dijke Peter
The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells.
Cancer research 2006;66(4):2202-9.
2006: ten Dijke P
Bone morphogenetic protein signal transduction in bone.
Current medical research and opinion 2006;22 Suppl 1():S7-11.
2006: Valdimarsdottir Gudrun; Goumans Marie-José; Itoh Fumiko; Itoh Susumu; Heldin Carl-Henrik; ten Dijke Peter
Smad7 and protein phosphatase 1alpha are critical determinants in the duration of TGF-beta/ALK1 signaling in endothelial cells.
BMC cell biology 2006;7():16.
2005: Bertolino Philippe; Deckers Martine; Lebrin Franck; ten Dijke Peter
Transforming growth factor-beta signal transduction in angiogenesis and vascular disorders.
Chest 2005;128(6 Suppl):585S-590S.
2005: Janssens Katrien; ten Dijke Peter; Janssens Sophie; Van Hul Wim
Transforming growth factor-beta1 to the bone.
Endocrine reviews 2005;26(6):743-74.
2005: Lin Amy H; Luo Jian; Mondshein Lauren H; ten Dijke Peter; Vivien Denis; Contag Christopher H; Wyss-Coray Tony
Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(1):547-54.
2005: van Bezooijen Rutger L; ten Dijke Peter; Papapoulos Socrates E; Löwik Clemens W G M
SOST/sclerostin, an osteocyte-derived negative regulator of bone formation.
Cytokine & growth factor reviews 2005;16(3):319-27.
2005: Sayama Koji; Komatsuzawa Hitoshi; Yamasaki Kenshi; Shirakata Yuji; Hanakawa Yasushi; Ouhara Kazuhisa; Tokumaru Sho; Dai Xiuju; Tohyama Mikiko; Ten Dijke Peter; Sugai Motoyuki; Ichijo Hidenori; Hashimoto Koji
New mechanisms of skin innate immunity: ASK1-mediated keratinocyte differentiation regulates the expression of beta-defensins, LL37, and TLR2.
European journal of immunology 2005;35(6):1886-95.
2005: Lebrin Franck; Deckers Martine; Bertolino Philippe; Ten Dijke Peter
TGF-beta receptor function in the endothelium.
Cardiovascular research 2005;65(3):599-608.
2004: Chuva de Sousa Lopes Susana M; Feijen Alie; Korving Jeroen; Korchynskyi Olexander; Larsson Jonas; Karlsson Stefan; ten Dijke Peter; Lyons Karen M; Goldschmeding Roel; Doevendans Pieter; Mummery Christine L
Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;231(3):542-50.
2004: Lebrin Franck; Goumans Marie-José; Jonker Leon; Carvalho Rita L C; Valdimarsdottir Gudrun; Thorikay Midory; Mummery Christine; Arthur Helen M; ten Dijke Peter
Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction.
The EMBO journal 2004;23(20):4018-28.
2004: Piek Ester; Van Dinther Maarten; Parks W Tony; Sallee John M; Böttinger Erwin P; Roberts Anita B; Ten Dijke Peter
RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta.
The Biochemical journal 2004;383(Pt 1):187-99.
2004: Monteiro Rui M; de Sousa Lopes Susana M Chuva; Korchynskyi Olexander; ten Dijke Peter; Mummery Christine L
Spatio-temporal activation of Smad1 and Smad5 in vivo: monitoring transcriptional activity of Smad proteins.
Journal of cell science 2004;117(Pt 20):4653-63.
2004: ten Dijke Peter; Hill Caroline S
New insights into TGF-beta-Smad signalling.
Trends in biochemical sciences 2004;29(5):265-73.
2004: van Bezooijen Rutger L; Roelen Bernard A J; Visser Annemieke; van der Wee-Pals Lianne; de Wilt Edwin; Karperien Marcel; Hamersma Herman; Papapoulos Socrates E; ten Dijke Peter; Löwik Clemens W G M
Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist.
The Journal of experimental medicine 2004;199(6):805-14.
2004: Lutz Marion; Krieglstein Kerstin; Schmitt Simone; ten Dijke Peter; Sebald Walter; Wizenmann Andrea; Knaus Petra
Nerve growth factor mediates activation of the Smad pathway in PC12 cells.
European journal of biochemistry / FEBS 2004;271(5):920-31.
2003: ten Dijke Peter; Korchynskyi Olexander; Valdimarsdottir Gudrun; Goumans Marie-José
Controlling cell fate by bone morphogenetic protein receptors.
Molecular and cellular endocrinology 2003;211(1-2):105-13.
2003: Goumans Marie José; Valdimarsdottir Gudrun; Itoh Susumu; Lebrin Franck; Larsson Jonas; Mummery Christine; Karlsson Stefan; ten Dijke Peter
Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling.
Molecular cell 2003;12(4):817-28.
2003: Althini S; Usoskin D; Kylberg A; ten Dijke P; Ebendal T
Bone morphogenetic protein signalling in NGF-stimulated PC12 cells.
Biochemical and biophysical research communications 2003;307(3):632-9.
2003: Korchynskyi Olexander; Dechering Koen J; Sijbers Anneke M; Olijve Wiebe; ten Dijke Peter
Gene array analysis of bone morphogenetic protein type I receptor-induced osteoblast differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(7):1177-85.
2003: Dooley Steven; Hamzavi Jafar; Breitkopf Katja; Wiercinska Eliza; Said Harun M; Lorenzen Johann; Ten Dijke Peter; Gressner Axel M
Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats.
Gastroenterology 2003;125(1):178-91.
2003: Kurisaki Keiko; Kurisaki Akira; Valcourt Ulrich; Terentiev Alexei A; Pardali Katerina; Ten Dijke Peter; Heldin Carl-Henrik; Ericsson Johan; Moustakas Aristidis
Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation.
Molecular and cellular biology 2003;23(13):4494-510.
2003: Liang Yao-Yun; Lin Xia; Liang Min; Brunicardi F Charles; ten Dijke Peter; Chen Zhihong; Choi Kwang-Wook; Feng Xin-Hua
dSmurf selectively degrades decapentaplegic-activated MAD, and its overexpression disrupts imaginal disc development.
The Journal of biological chemistry 2003;278(29):26307-10.
2003: de Sousa Lopes Susana M Chuva; Carvalho Rita L C; van den Driesche Sander; Goumans Marie José; ten Dijke Peter; Mummery Christine L
Distribution of phosphorylated Smad2 identifies target tissues of TGF beta ligands in mouse development.
Gene expression patterns : GEP 2003;3(3):355-60.
2003: Ikedo Hirofumi; Tamaki Kiyoshi; Ueda Seiji; Kato Seiya; Fujii Makiko; Ten Dijke Peter; Okuda Seiya
Smad protein and TGF-beta signaling in vascular smooth muscle cells.
International journal of molecular medicine 2003;11(5):645-50.
2003: Suh Nanjoo; Roberts Anita B; Birkey Reffey Stephanie; Miyazono Kohei; Itoh Susumu; ten Dijke Peter; Heiss Elke H; Place Andrew E; Risingsong Renee; Williams Charlotte R; Honda Tadashi; Gribble Gordon W; Sporn Michael B
Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling.
Cancer research 2003;63(6):1371-6.
2003: Edlund Sofia; Bu Shizhong; Schuster Norbert; Aspenström Pontus; Heuchel Rainer; Heldin Nils-Erik; ten Dijke Peter; Heldin Carl-Henrik; Landström Maréne
Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3.
Molecular biology of the cell 2003;14(2):529-44.
2003: Kaivo-Oja Noora; Bondestam Jonas; Kämäräinen Meerit; Koskimies Janne; Vitt Ursula; Cranfield Mark; Vuojolainen Kaisa; Kallio Janne P; Olkkonen Vesa M; Hayashi Masaru; Moustakas Aristidis; Groome Nigel P; ten Dijke Peter; Hsueh Aaron J W; Ritvos Olli
Growth differentiation factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells.
The Journal of clinical endocrinology and metabolism 2003;88(2):755-62.
2003: Janssens Katrien; ten Dijke Peter; Ralston Stuart H; Bergmann Carsten; Van Hul Wim
Transforming growth factor-beta 1 mutations in Camurati-Engelmann disease lead to increased signaling by altering either activation or secretion of the mutant protein.
The Journal of biological chemistry 2003;278(9):7718-24.
2003: Itoh Susumu; Thorikay Midory; Kowanetz Marcin; Moustakas Aristidis; Itoh Fumiko; Heldin Carl-Henrik; ten Dijke Peter
Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses.
The Journal of biological chemistry 2003;278(6):3751-61.
2003: ten Dijke Peter; Fu Jingyuan; Schaap Peter; Roelen Bernard A J
Signal transduction of bone morphogenetic proteins in osteoblast differentiation.
The Journal of bone and joint surgery. American volume 2003;85-A Suppl 3():34-8.
2002: Chang Weise; ten Dijke Peter; Wu Doris K
BMP pathways are involved in otic capsule formation and epithelial-mesenchymal signaling in the developing chicken inner ear.
Developmental biology 2002;251(2):380-94.
2002: Valdimarsdottir Gudrun; Goumans Marie-José; Rosendahl Alexander; Brugman Martijn; Itoh Susumu; Lebrin Franck; Sideras Paschalis; ten Dijke Peter
Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells.
Circulation 2002;106(17):2263-70.
2002: Muehleman Carol; Kuettner Klaus E; Rueger David C; Ten Dijke Peter; Chubinskaya Susan
Immunohistochemical localization of osteogenetic protein (OP-1) and its receptors in rabbit articular cartilage.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002;50(10):1341-50.
2002: Bondestam Jonas; Kaivo-oja Noora; Kallio Janne; Groome Nigel; Hydén-Granskog Christel; Fujii Makiko; Moustakas Aristidis; Jalanko Anu; ten Dijke Peter; Ritvos Olli
Engagement of activin and bone morphogenetic protein signaling pathway Smad proteins in the induction of inhibin B production in ovarian granulosa cells.
Molecular and cellular endocrinology 2002;195(1-2):79-88.
2002: Rosendahl Alexander; Pardali Evangelia; Speletas Matthaios; Ten Dijke Peter; Heldin Carl-Henrik; Sideras Paschalis
Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation.
American journal of respiratory cell and molecular biology 2002;27(2):160-9.
2002: He Wei; Li Allen G; Wang Dongyan; Han Shuhua; Zheng Biao; Goumans Marie-José; Ten Dijke Peter; Wang Xiao-Jing
Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues.
The EMBO journal 2002;21(11):2580-90.
2002: Dennler Sylviane; Goumans Marie-José; ten Dijke Peter
Transforming growth factor beta signal transduction.
Journal of leukocyte biology 2002;71(5):731-40.
2002: Goumans Marie-José; Valdimarsdottir Gudrun; Itoh Susumu; Rosendahl Alexander; Sideras Paschalis; ten Dijke Peter
Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors.
The EMBO journal 2002;21(7):1743-53.
2002: Ten Dijke Peter; Goumans Marie-José; Itoh Fumiko; Itoh Susumu
Regulation of cell proliferation by Smad proteins.
Journal of cellular physiology 2002;191(1):1-16.
2002: Dong Chunming; Zhu Shoukang; Wang Tao; Yoon Woohyun; Li Zhiru; Alvarez Rene J; ten Dijke Peter; White Barbara; Wigley Fredrick M; Goldschmidt-Clermont Pascal J
Deficient Smad7 expression: a putative molecular defect in scleroderma.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3908-13.
2002: Ohkawara Bisei; Iemura Shun-ichiro; ten Dijke Peter; Ueno Naoto
Action range of BMP is defined by its N-terminal basic amino acid core.
Current biology : CB 2002;12(3):205-9.
2002: Korchynskyi Olexander; ten Dijke Peter
Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter.
The Journal of biological chemistry 2002;277(7):4883-91.
2002: Blokzijl Andries; ten Dijke Peter; Ibáñez Carlos F
Physical and functional interaction between GATA-3 and Smad3 allows TGF-beta regulation of GATA target genes.
Current biology : CB 2002;12(1):35-45.
2002: Fan Xiaolong; Valdimarsdottir Gudrun; Larsson Jonas; Brun Ann; Magnusson Mattias; Jacobsen Sten Eirik; ten Dijke Peter; Karlsson Stefan
Transient disruption of autocrine TGF-beta signaling leads to enhanced survival and proliferation potential in single primitive human hemopoietic progenitor cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):755-62.
2001: Kato S; Ueda S; Tamaki K; Fujii M; Miyazono K; ten Dijke P; Morimatsu M; Okuda S
Ectopic expression of Smad7 inhibits transforming growth factor-beta responses in vascular smooth muscle cells.
Life sciences 2001;69(22):2641-52.
2001: Itoh F; Asao H; Sugamura K; Heldin C H; ten Dijke P; Itoh S
Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads.
The EMBO journal 2001;20(15):4132-42.
2001: Olsson N; Piek E; Sundström M; ten Dijke P; Nilsson G
Transforming growth factor-beta-mediated mast cell migration depends on mitogen-activated protein kinase activity.
Cellular signalling 2001;13(7):483-90.
2001: Dooley S; Delvoux B; Streckert M; Bonzel L; Stopa M; ten Dijke P; Gressner A M
Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFbeta signal transduction during transdifferentiation of hepatic stellate cells.
FEBS letters 2001;502(1-2):4-10.
2001: Rosendahl A; Checchin D; Fehniger T E; ten Dijke P; Heldin C H; Sideras P
Activation of the TGF-beta/activin-Smad2 pathway during allergic airway inflammation.
American journal of respiratory cell and molecular biology 2001;25(1):60-8.
2001: Larsson J; Goumans M J; Sjöstrand L J; van Rooijen M A; Ward D; Levéen P; Xu X; ten Dijke P; Mummery C L; Karlsson S
Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice.
The EMBO journal 2001;20(7):1663-73.
2001: Hayes S A; Zarnegar M; Sharma M; Yang F; Peehl D M; ten Dijke P; Sun Z
SMAD3 represses androgen receptor-mediated transcription.
Cancer research 2001;61(5):2112-8.
2001: Yakymovych I; Ten Dijke P; Heldin C H; Souchelnytskyi S
Regulation of Smad signaling by protein kinase C.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(3):553-5.
2001: Jörnvall H; Blokzijl A; ten Dijke P; Ibáñez C F
The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line.
The Journal of biological chemistry 2001;276(7):5140-6.
2001: Bondestam J; Huotari M A; Morén A; Ustinov J; Kaivo-Oja N; Kallio J; Horelli-Kuitunen N; Aaltonen J; Fujii M; Moustakas A; Ten Dijke P; Otonkoski T; Ritvos O
cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C).
Cytogenetics and cell genetics 2001;95(3-4):157-62.
2000: Itoh S; Itoh F; Goumans M J; Ten Dijke P
Signaling of transforming growth factor-beta family members through Smad proteins.
European journal of biochemistry / FEBS 2000;267(24):6954-67.
2000: Itoh S; Ericsson J; Nishikawa J; Heldin C H; ten Dijke P
The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling.
Nucleic acids research 2000;28(21):4291-8.
2000: Pardali K; Kurisaki A; Morén A; ten Dijke P; Kardassis D; Moustakas A
Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.
The Journal of biological chemistry 2000;275(38):29244-56.
2000: Brodin G; Ahgren A; ten Dijke P; Heldin C H; Heuchel R
Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter.
The Journal of biological chemistry 2000;275(37):29023-30.
2000: Zwijsen A; van Rooijen M A; Goumans M J; Dewulf N; Bosman E A; ten Dijke P; Mummery C L; Huylebroeck D
Expression of the inhibitory Smad7 in early mouse development and upregulation during embryonic vasculogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 2000;218(4):663-70.
2000: Landström M; Heldin N E; Bu S; Hermansson A; Itoh S; ten Dijke P; Heldin C H
Smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells.
Current biology : CB 2000;10(9):535-8.
2000: Olsson N; Piek E; ten Dijke P; Nilsson G
Human mast cell migration in response to members of the transforming growth factor-beta family.
Journal of leukocyte biology 2000;67(3):350-6.
2000: ten Dijke P; Miyazono K; Heldin C H
Signaling inputs converge on nuclear effectors in TGF-beta signaling.
Trends in biochemical sciences 2000;25(2):64-70.
2000: Pardali E; Xie X Q; Tsapogas P; Itoh S; Arvanitidis K; Heldin C H; ten Dijke P; Grundström T; Sideras P
Smad and AML proteins synergistically confer transforming growth factor beta1 responsiveness to human germ-line IgA genes.
The Journal of biological chemistry 2000;275(5):3552-60.
1999: Piek E; Heldin C H; Ten Dijke P
Specificity, diversity, and regulation in TGF-beta superfamily signaling.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(15):2105-24.
1999: Piek E; Moustakas A; Kurisaki A; Heldin C H; ten Dijke P
TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells.
Journal of cell science 1999;112 ( Pt 24)():4557-68.
1999: Franzén A; Piek E; Westermark B; ten Dijke P; Heldin N E
Expression of transforming growth factor-beta1, activin A, and their receptors in thyroid follicle cells: negative regulation of thyrocyte growth and function.
Endocrinology 1999;140(9):4300-10.
1999: Piek E; Afrakhte M; Sampath K; van Zoelen E J; Heldin C H; ten Dijke P
Functional antagonism between activin and osteogenic protein-1 in human embryonal carcinoma cells.
Journal of cellular physiology 1999;180(2):141-9.
1999: Heldin N E; Bergström D; Hermansson A; Bergenstråhle A; Nakao A; Westermark B; ten Dijke P
Lack of responsiveness to TGF-beta1 in a thyroid carcinoma cell line with functional type I and type II TGF-beta receptors and Smad proteins, suggests a novel mechanism for TGF-beta insensitivity in carcinoma cells.
Molecular and cellular endocrinology 1999;153(1-2):79-90.
1999: Korchynskyi O; Landström M; Stoika R; Funa K; Heldin C H; ten Dijke P; Souchelnytskyi S
Expression of Smad proteins in human colorectal cancer.
International journal of cancer. Journal international du cancer 1999;82(2):197-202.
1999: Brodin G; ten Dijke P; Funa K; Heldin C H; Landström M
Increased smad expression and activation are associated with apoptosis in normal and malignant prostate after castration.
Cancer research 1999;59(11):2731-8.
1999: Lange D; Persson U; Wollina U; ten Dijke P; Castelli E; Heldin C H; Funa K
Expression of TGF-beta related Smad proteins in human epithelial skin tumors.
International journal of oncology 1999;14(6):1049-56.
1999: Wollina U; Lange D; Ten Dijke P; Heldin C H; Funa K
Eccrine sweat glands: expression of transforming growth factor-beta and bone morphogenetic protein type I receptors and their intracellular signalling Smad proteins.
Acta dermato-venereologica 1999;79(3):183-6.
1999: Aström A K; Jin D; Imamura T; Röijer E; Rosenzweig B; Miyazono K; ten Dijke P; Stenman G
Chromosomal localization of three human genes encoding bone morphogenetic protein receptors.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(3):299-302.
1999: Piek E; Westermark U; Kastemar M; Heldin C H; van Zoelen E J; Nistér M; Ten Dijke P
Expression of transforming-growth-factor (TGF)-beta receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF-beta1.
International journal of cancer. Journal international du cancer 1999;80(5):756-63.
1999: Jonson T; Gorunova L; Dawiskiba S; Andrén-Sandberg A; Stenman G; ten Dijke P; Johansson B; Höglund M
Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer.
Genes, chromosomes & cancer 1999;24(1):62-71.
1998: Tamaki K; Souchelnytskyi S; Itoh S; Nakao A; Sampath K; Heldin C H; ten Dijke P
Intracellular signaling of osteogenic protein-1 through Smad5 activation.
Journal of cellular physiology 1998;177(2):355-63.
1998: Itóh S; Landström M; Hermansson A; Itoh F; Heldin C H; Heldin N E; ten Dijke P
Transforming growth factor beta1 induces nuclear export of inhibitory Smad7.
The Journal of biological chemistry 1998;273(44):29195-201.
1998: Souchelnytskyi S; Nakayama T; Nakao A; Morén A; Heldin C H; Christian J L; ten Dijke P
Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors.
The Journal of biological chemistry 1998;273(39):25364-70.
1998: Persson U; Izumi H; Souchelnytskyi S; Itoh S; Grimsby S; Engström U; Heldin C H; Funa K; ten Dijke P
The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation.
FEBS letters 1998;434(1-2):83-7.
1998: Afrakhte M; Morén A; Jossan S; Itoh S; Sampath K; Westermark B; Heldin C H; Heldin N E; ten Dijke P
Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members.
Biochemical and biophysical research communications 1998;249(2):505-11.
1998: Röijer E; Miyazono K; Aström A K; Geurts van Kessel A; ten Dijke P; Stenman G
Chromosomal localization of three human genes encoding members of the TGF-beta superfamily of type I serine/threonine kinase receptors.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(3):266-8.
1998: Röijer E; Morén A; ten Dijke P; Stenman G
Assignment1 of the Smad7 gene (MADH7) to human chromosome 18q21.1 by fluorescence in situ hybridization.
Cytogenetics and cell genetics 1998;81(3-4):189-90.
1997: Heldin C H; Miyazono K; ten Dijke P
TGF-beta signalling from cell membrane to nucleus through SMAD proteins.
Nature 1997;390(6659):465-71.
1997: Piek E; Franzén P; Heldin C H; ten Dijke P
Characterization of a 60-kDa cell surface-associated transforming growth factor-beta binding protein that can interfere with transforming growth factor-beta receptor binding.
Journal of cellular physiology 1997;173(3):447-59.
1997: Souchelnytskyi S; Tamaki K; Engström U; Wernstedt C; ten Dijke P; Heldin C H
Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling.
The Journal of biological chemistry 1997;272(44):28107-15.
1997: Nakao A; Afrakhte M; Morén A; Nakayama T; Christian J L; Heuchel R; Itoh S; Kawabata M; Heldin N E; Heldin C H; ten Dijke P
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.
Nature 1997;389(6651):631-5.
1997: Nakao A; Imamura T; Souchelnytskyi S; Kawabata M; Ishisaki A; Oeda E; Tamaki K; Hanai J; Heldin C H; Miyazono K; ten Dijke P
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.
The EMBO journal 1997;16(17):5353-62.
1997: Persson U; Souchelnytskyi S; Franzén P; Miyazono K; ten Dijke P; Heldin C H
Transforming growth factor (TGF-beta)-specific signaling by chimeric TGF-beta type II receptor with intracellular domain of activin type IIB receptor.
The Journal of biological chemistry 1997;272(34):21187-94.
1997: Olofsson A; Hellman U; Ten Dijke P; Grimsby S; Ichijo H; Morén A; Miyazono K; Heldin C H
Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160.
The Biochemical journal 1997;324 ( Pt 2)():427-34.
1997: de Winter J P; Roelen B A; ten Dijke P; van der Burg B; van den Eijnden-van Raaij A J
DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells.
Oncogene 1997;14(16):1891-9.
1997: Nakao A; Röijer E; Imamura T; Souchelnytskyi S; Stenman G; Heldin C H; ten Dijke P
Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway.
The Journal of biological chemistry 1997;272(5):2896-900.
1996: Souchelnytskyi S; ten Dijke P; Miyazono K; Heldin C H
Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses.
The EMBO journal 1996;15(22):6231-40.
1996: Rydén M; Imamura T; Jörnvall H; Belluardo N; Neveu I; Trupp M; Okadome T; ten Dijke P; Ibáñez C F
A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system.
The Journal of biological chemistry 1996;271(48):30603-9.
1996: ten Dijke P; Miyazono K; Heldin C H
Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors.
Current opinion in cell biology 1996;8(2):139-45.
1996: Yamada N; Kato M; ten Dijke P; Yamashita H; Sampath T K; Heldin C H; Miyazono K; Funa K
Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours.
British journal of cancer 1996;73(5):624-9.
1996: de Winter J P; ten Dijke P; de Vries C J; van Achterberg T A; Sugino H; de Waele P; Huylebroeck D; Verschueren K; van den Eijnden-van Raaij A J
Follistatins neutralize activin bioactivity by inhibition of activin binding to its type II receptors.
Molecular and cellular endocrinology 1996;116(1):105-14.
1995: Olofsson A; Ichijo H; Morén A; ten Dijke P; Miyazono K; Heldin C H
Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix.
The Journal of biological chemistry 1995;270(52):31294-7.
1995: Rosenzweig B L; Imamura T; Okadome T; Cox G N; Yamashita H; ten Dijke P; Heldin C H; Miyazono K
Cloning and characterization of a human type II receptor for bone morphogenetic proteins.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):7632-6.
1995: Yamashita H; ten Dijke P; Huylebroeck D; Sampath T K; Andries M; Smith J C; Heldin C H; Miyazono K
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.
The Journal of cell biology 1995;130(1):217-26.
1995: Verschueren K; Dewulf N; Goumans M J; Lonnoy O; Feijen A; Grimsby S; Vandi Spiegle K; ten Dijke P; Morén A; Vanscheeuwijck P; Heldin C H; Miyazono K; Mummery C; Van Den Eijnden-Van Raaij J; Huylebroeck D
Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis.
Mechanisms of development 1995;52(1):109-23.
1995: Dewulf N; Verschueren K; Lonnoy O; Morén A; Grimsby S; Vande Spiegle K; Miyazono K; Huylebroeck D; Ten Dijke P
Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis.
Endocrinology 1995;136(6):2652-63.
1995: Yamashita H; Okadome T; Franzén P; ten Dijke P; Heldin C H; Miyazono K
A rat pituitary tumor cell line (GH3) expresses type I and type II receptors and other cell surface binding protein(s) for transforming growth factor-beta.
The Journal of biological chemistry 1995;270(2):770-4.
1994: Morén A; Olofsson A; Stenman G; Sahlin P; Kanzaki T; Claesson-Welsh L; ten Dijke P; Miyazono K; Heldin C H
Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein.
The Journal of biological chemistry 1994;269(51):32469-78.
1994: Miyazono K; ten Dijke P; Yamashita H; Heldin C H
Signal transduction via serine/threonine kinase receptors.
Seminars in cell biology 1994;5(6):389-98.
1994: Yamashita H; ten Dijke P; Franzén P; Miyazono K; Heldin C H
Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.
The Journal of biological chemistry 1994;269(31):20172-8.
1994: ten Dijke P; Yamashita H; Sampath T K; Reddi A H; Estevez M; Riddle D L; Ichijo H; Heldin C H; Miyazono K
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.
The Journal of biological chemistry 1994;269(25):16985-8.
1994: Taketazu F; Kato M; Gobl A; Ichijo H; ten Dijke P; Itoh J; Kyogoku M; Rönnelid J; Miyazono K; Heldin C H
Enhanced expression of transforming growth factor-beta s and transforming growth factor-beta type II receptor in the synovial tissues of patients with rheumatoid arthritis.
Laboratory investigation; a journal of technical methods and pathology 1994;70(5):620-30.
1994: ten Dijke P; Yamashita H; Ichijo H; Franzén P; Laiho M; Miyazono K; Heldin C H
Characterization of type I receptors for transforming growth factor-beta and activin.
Science (New York, N.Y.) 1994;264(5155):101-4.
1994: Yamashita H; Ichijo H; Grimsby S; Morén A; ten Dijke P; Miyazono K
Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta.
The Journal of biological chemistry 1994;269(3):1995-2001.
1994: Miyazono K; Ten Dijke P; Ichijo H; Heldin C H
Receptors for transforming growth factor-beta.
Advances in immunology 1994;55():181-220.
1994: ten Dijke P; Franzén P; Yamashita H; Ichijo H; Heldin C H; Miyazono K
Serine/threonine kinase receptors.
Progress in growth factor research 1994;5(1):55-72.
1993: Franzén P; ten Dijke P; Ichijo H; Yamashita H; Schulz P; Heldin C H; Miyazono K
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor.
Cell 1993;75(4):681-92.
1993: ten Dijke P; Ichijo H; Franzén P; Schulz P; Saras J; Toyoshima H; Heldin C H; Miyazono K
Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.
Oncogene 1993;8(10):2879-87.
1993: Ichijo H; Yamashita H; ten Dijke P; Eto Y; Heldin C H; Miyazono K
Characterization of in vivo phosphorylation of activin type II receptor.
Biochemical and biophysical research communications 1993;194(3):1508-14.

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