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Manuel Tena-Sempere

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Francisco Gaytan; Silvia León; María Manfredi-Lozano; Concepción Morales; Leonor Pinilla; Antonio Romero-Ruiz; Francisco Ruiz-Pino; Susana Sangiao-Alvarellos; Fernando Cordido; David García-Galiano; Manuel Tena-Sempere
Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism.
Susana Sangiao-Alvarellos; Fernando Cordido; Carlos Dieguez; Gregory A Dissen; S Leon; M Manfredi-Lozano; Valerie Matagne; Victor M Navarro; Sergio R Ojeda; Leonor Pinilla; F Ruiz-Pino; Miguel Angel Sánchez-Garrido; Manuel Tena-Sempere
Changes in hypothalamic expression of the Lin28/let-7 system and related microRNAs during postnatal maturation and after experimental manipulations of puberty.
Manuel Tena-Sempere
Ghrelin, the gonadal axis and the onset of puberty.

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2013: Francisco Gaytan; Silvia León; María Manfredi-Lozano; Concepción Morales; Leonor Pinilla; Antonio Romero-Ruiz; Francisco Ruiz-Pino; Susana Sangiao-Alvarellos; Fernando Cordido; David García-Galiano; Manuel Tena-Sempere
Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism.
Endocrinology 2013;154(3):1321-36.
2013: Susana Sangiao-Alvarellos; Fernando Cordido; Carlos Dieguez; Gregory A Dissen; S Leon; M Manfredi-Lozano; Valerie Matagne; Victor M Navarro; Sergio R Ojeda; Leonor Pinilla; F Ruiz-Pino; Miguel Angel Sánchez-Garrido; Manuel Tena-Sempere
Changes in hypothalamic expression of the Lin28/let-7 system and related microRNAs during postnatal maturation and after experimental manipulations of puberty.
Endocrinology 2013;154(2):942-55.
2013: Manuel Tena-Sempere
Ghrelin, the gonadal axis and the onset of puberty.
Endocrine development 2013;25():69-82.
2013: Juan Manuel Castellano; Manuel Tena-Sempere
Metabolic regulation of kisspeptin.
Advances in experimental medicine and biology 2013;784():363-83.
2013: Alexander V Sirotkin; Manuel Tena-Sempere; Roland Grossmann; Magdalena Romero Jiménez; Silvia Pavlova; Juan Manuel Castellano Rodriguez; Francisco Valenzuela
Food restriction, ghrelin, its antagonist and obestatin control expression of ghrelin and its receptor in chicken hypothalamus and ovary.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2013;164(1):141-53.
2013: José María Moreno-Navarrete; Francisco Ortega; Wifredo Ricart; Mònica Sabater; Miguel Ángel Sánchez-Garrido; Manuel Tena-Sempere; Antonio Zorzano; José Manuel Fernández-Real
Phosphorylated S6K1 (Thr389) is a molecular adipose tissue marker of altered glucose tolerance.
The Journal of nutritional biochemistry 2013;24(1):32-8.
2012: Manuel Tena-Sempere
Deciphering puberty: novel partners, novel mechanisms.
European journal of endocrinology / European Federation of Endocrine Societies 2012;167(6):733-47.
2012: Fatima Qaiser; Rizwan Hashim; Jerome Leprince; Manuel Tena-Sempere; Hubert Vaudry; Fazal Wahab; Muhammad Amin Wiqar; M Shahab
Study of the role of novel RF-amide neuropeptides in affecting growth hormone secretion in a representative non-human primate (Macaca mulatta).
Endocrine 2012;42(3):658-63.
2012: David García-Galiano; Victor M Navarro; Rafael Pineda; Leonor Pinilla; Juan Roa; Francisco Ruiz-Pino; Miguel Angel Sánchez-Garrido; Enrique Aguilar; Juan M Castellano; Manuel Tena-Sempere
Differential modulation of gonadotropin responses to kisspeptin by aminoacidergic, peptidergic, and nitric oxide neurotransmission.
American journal of physiology. Endocrinology and metabolism 2012;303(10):E1252-63.
2012: Esther Fuente-Martín; Cristina García-Cáceres; Miriam Granado; Tamas L Horvath; Zhong-Wu Liu; Miguel Ángel Sánchez-Garrido; Beatrix Sarman; Manuel Tena-Sempere; Jesús Argente; Pilar Argente-Arizón; María L de Ceballos; Francisca Díaz; Marcelo O Dietrich; Julie A Chowen
Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes.
The Journal of clinical investigation 2012;122(11):3900-13.
2012: F Ruiz-Pino; Miguel Angel Sánchez-Garrido; R A Steiner; A H Bentsen; P Ciofi; D Garcia-Galiano; J D Mikkelsen; Victor M Navarro; Leonor Pinilla; Manuel Tena-Sempere
Neurokinin B and the control of the gonadotropic axis in the rat: developmental changes, sexual dimorphism, and regulation by gonadal steroids.
Endocrinology 2012;153(10):4818-29.
2012: Leonor Pinilla; Enrique Aguilar; Carlos Dieguez; Robert P Millar; Manuel Tena-Sempere
Kisspeptins and reproduction: physiological roles and regulatory mechanisms.
Physiological reviews 2012;92(3):1235-316.
2012: Fazal Wahab; Manuel Tena-Sempere; Hubert Vaudry; Mariam Anees; Jerome Leprince; Hina Salahuddin; M Shahab
Study of the effect of 26RF- and 43RF-amides on testosterone and prolactin secretion in the adult male rhesus monkey (Macaca mulatta).
Peptides 2012;36(1):23-8.
2012: Esther Fuente-Martín; Cristina García-Cáceres; Miriam Granado; Miguel A Sánchez-Garrido; Manuel Tena-Sempere; Jesús Argente; Laura Frago; Julie A Chowen
Early postnatal overnutrition increases adipose tissue accrual in response to a sucrose-enriched diet.
American journal of physiology. Endocrinology and metabolism 2012;302(12):E1586-98.
2012: Luis Varela; María Jesús Vázquez; Krishna Chatterjee; Carlos Diéguez; Rosalía Gallego; Marina Gándara; Noelia Martínez-Sánchez; Rubén Nogueiras; Juan Roa; Erik Schoenmakers; Manuel Tena-Sempere; Miguel López
Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism.
The Journal of pathology 2012;227(2):209-22.
2012: Esther Fuente-Martín; Cristina García-Cáceres; Miriam Granado; Miguel A Sanchez-Garrido; Manuel Tena-Sempere; Jesús Argente; Laura Frago; Julie A Chowen
Early nutritional changes induce sexually dimorphic long-term effects on body weight gain and the response to sucrose intake in adult rats.
Metabolism: clinical and experimental 2012;61(6):812-22.
2012: Antonio Cejudo Roman; Idaira Dorta; Mariano Hernández; Matilde Illanes; Francisco M Pinto; Manuel Tena-Sempere; Teresa A Almeida; Luz Candenas
Analysis of the expression of neurokinin B, kisspeptin, and their cognate receptors NK3R and KISS1R in the human female genital tract.
Fertility and sterility 2012;97(5):1213-9.
2012: D García-Galiano; Francisco Gaytán; T Ilhan; Rafael Pineda; Leonor Pinilla; Antonio Romero-Ruiz; F Ruiz-Pino; Miguel Angel Sánchez-Garrido; Susana Sangiao-Alvarellos; Juan M Castellano; Carlos Diéguez; MJ Vazquez; Manuel Tena-Sempere
Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis.
Endocrinology 2012;153(4):1959-71.
2012: Caroline Ancel; Agnete H Bentsen; Jens D Mikkelsen; Marie-Emilie Sébert; Manuel Tena-Sempere; Valérie Simonneaux
Stimulatory effect of RFRP-3 on the gonadotrophic axis in the male Syrian hamster: the exception proves the rule.
Endocrinology 2012;153(3):1352-63.
2012: Victor M Navarro; Leonor Pinilla; Francisco Ruiz-Pino; Miguel Angel Sánchez-Garrido; Susana Sangiao-Alvarellos; Robert A Steiner; Juan M Castellano; Donald K Clifton; David García-Galiano; Samuel J Hobbs; Silvia León; María Manfredi-Lozano; Manuel Tena-Sempere
Role of neurokinin B in the control of female puberty and its modulation by metabolic status.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(7):2388-97.
2012: Luís Martins; Rubén Nogueiras; Marta G Novelle; Manuel Tena-Sempere; María Jesús Vázquez; Diana Fernández-Mallo; Miguel López; Carlos Diéguez
Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin.
PloS one 2012;7(10):e46923.
2011: Cesar A Meza-Herrera; Homero Salinas-Gonzalez; Manuel Tena-Sempere; Jose Abad-Zavaleta; Antonio González-Bulnes; Luis C Hernández-Valenzuela; Miguel Mellado; Francisco Veliz-Deras
Long-term betacarotene-supplementation enhances serum insulin concentrations without effect on the onset of puberty in the female goat.
Reproductive biology 2011;11(3):236-49.
2011: Victor M Navarro; Richard D Palmiter; Leonor Pinilla; Oline K Ronnekleiv; Manuel Tena-Sempere; M Wu; M Alreja; Martha A Bosch; R E Braun; Donald K Clifton; A Dearth; D García-Galiano; Michelle L Gottsch; S J Hobbs; Robert A Steiner
Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse.
Endocrinology 2011;152(11):4265-75.
2011: Juan Roa; Victor M Navarro; Manuel Tena-Sempere
Kisspeptins in reproductive biology: consensus knowledge and recent developments.
Biology of reproduction 2011;85(4):650-60.
2011: Juan M Castellano; Carlos Diéguez; David Garcia-Galiano; Jens D Mikkelsen; Leonor Pinilla; Magdalena Romero; Francisco Ruiz-Pino; Miguel Angel Sánchez-Garrido; Enrique Aguilar; Agnete H Bentsen; Manuel Tena-Sempere
Early metabolic programming of puberty onset: impact of changes in postnatal feeding and rearing conditions on the timing of puberty and development of the hypothalamic kisspeptin system.
Endocrinology 2011;152(9):3396-408.
2011: Pablo Blanco Martínez de Morentin; Carlos Diéguez; Carmen R González; Luís Martins; Asisk K Saha; Manuel Tena-Sempere; Antonio Vidal-Puig; Miguel López
Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance.
Reviews in endocrine & metabolic disorders 2011;12(3):127-40.
2011: Olivier Le Marec; Benjamin Lefranc; Jean A Boutin; Jean Costentin; Jean-Claude Do-Régo; Christophe Dubessy; Cindy Neveu; Manuel Tena-Sempere; Marie-Christine Tonon; Hubert Vaudry; Jérôme Leprince
Structure-activity relationships of a series of analogues of the RFamide-related peptide 26RFa.
Journal of medicinal chemistry 2011;54(13):4806-14.
2011: Leonor Pinilla; Rafael Pineda; Francisco Gaytán; Magdalena Romero; David García-Galiano; Miguel Angel Sánchez-Garrido; Francisco Ruiz-Pino; Manuel Tena-Sempere; Enrique Aguilar
Characterization of the reproductive effects of the anorexigenic VGF-derived peptide TLQP-21: in vivo and in vitro studies in male rats.
American journal of physiology. Endocrinology and metabolism 2011;300(5):E837-47.
2011: S Tapia-González; Lhav M García-Segura; Manuel Tena-Sempere; Laura Frago; Juan M Castellano; E Fuente-Martín; C García-Cáceres; Jesús Argente; Julie A Chowen
Activation of microglia in specific hypothalamic nuclei and the cerebellum of adult rats exposed to neonatal overnutrition.
Journal of neuroendocrinology 2011;23(4):365-70.
2011: Raul M Luque; José Córdoba-Chacón; Manuel D Gahete; Victor M Navarro; Manuel Tena-Sempere; Rhonda D Kineman; Justo P Castaño
Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms.
Endocrinology 2011;152(3):957-66.
2011: Victor M Navarro; Manuel Tena-Sempere
Kisspeptins and the neuroendocrine control of reproduction.
Frontiers in bioscience (Scholar edition) 2011;3():267-75.
2011: Victor M Navarro; Juan M Castellano; Sarah M McConkey; Rafael Pineda; Francisco Ruiz-Pino; Leonor Pinilla; Donald K Clifton; Manuel Tena-Sempere; Robert A Steiner
Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat.
American journal of physiology. Endocrinology and metabolism 2011;300(1):E202-10.
2010: Juan M Castellano; Agnete H Bentsen; Jens D Mikkelsen; Manuel Tena-Sempere
Kisspeptins: bridging energy homeostasis and reproduction.
Brain research 2010;1364():129-38.
2010: David García-Galiano; Victor M Navarro; Francisco Gaytan; Manuel Tena-Sempere
Expanding roles of NUCB2/nesfatin-1 in neuroendocrine regulation.
Journal of molecular endocrinology 2010;45(5):281-90.
2010: Juan Roa; Manuel Tena-Sempere
Energy balance and puberty onset: emerging role of central mTOR signaling.
Trends in endocrinology and metabolism: TEM 2010;21(9):519-28.
2010: Manuel Tena-Sempere
Neuroendocrinology of puberty: recent milestones and new challenges.
Molecular and cellular endocrinology 2010;324(1-2):1-2.
2010: Juan Roa; David García-Galiano; Juan M Castellano; Francisco Gaytan; Leonor Pinilla; Manuel Tena-Sempere
Metabolic control of puberty onset: new players, new mechanisms.
Molecular and cellular endocrinology 2010;324(1-2):87-94.
2010: Rafael Pineda; D Garcia-Galiano; Miguel Angel Sánchez-Garrido; M Romero; F Ruiz-Pino; Enrique Aguilar; F A Dijcks; M Blomenröhr; Leonor Pinilla; P I van Noort; Manuel Tena-Sempere
Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of GnIH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studies.
American journal of physiology. Endocrinology and metabolism 2010;299(1):E39-46.
2010: Juan M Castellano; A H Bentsen; M Romero; Rafael Pineda; F Ruiz-Pino; D Garcia-Galiano; Miguel Angel Sánchez-Garrido; Leonor Pinilla; J D Mikkelsen; Manuel Tena-Sempere
Acute inflammation reduces kisspeptin immunoreactivity at the arcuate nucleus and decreases responsiveness to kisspeptin independently of its anorectic effects.
American journal of physiology. Endocrinology and metabolism 2010;299(1):E54-61.
2010: David García-Galiano; Victor M Navarro; Juan Roa; Francisco Ruiz-Pino; Miguel Angel Sánchez-Garrido; Rafael Pineda; Juan M Castellano; Magdalena Romero; Enrique Aguilar; Francisco Gaytán; Carlos Diéguez; Leonor Pinilla; Manuel Tena-Sempere
The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(23):7783-92.
2010: Manuel Tena-Sempere
Kisspeptins and the metabolic control of reproduction: physiologic roles and physiopathological implications.
Annales d'endocrinologie 2010;71(3):201-2.
2010: Rafael Pineda; D Garcia-Galiano; Miguel Angel Sánchez-Garrido; M Romero; F Ruiz-Pino; Enrique Aguilar; F A Dijcks; M Blomenröhr; Leonor Pinilla; P I van Noort; Manuel Tena-Sempere
Characterization of the potent gonadotropin-releasing activity of RF9, a selective antagonist of RF-amide-related peptides and neuropeptide FF receptors: physiological and pharmacological implications.
Endocrinology 2010;151(4):1902-13.
2010: Manuel Tena-Sempere
Kisspeptin/GPR54 system as potential target for endocrine disruption of reproductive development and function.
International journal of andrology 2010;33(2):360-8.
2010: Miguel López; Manuel Tena-Sempere; Carlos Diéguez
Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes).
Frontiers in neuroendocrinology 2010;31(2):113-27.
2010: Miguel López; Rubén Nogueiras; Manuel Tena-Sempere; Carlos Diéguez
Orexins (hypocretins) actions on the GHRH/somatostatin-GH axis.
Acta physiologica (Oxford, England) 2010;198(3):325-34.
2010: Mirja Nurmio; Manuel Tena-Sempere; Jorma Toppari
Orexins and the regulation of the hypothalamic-pituitary-testicular axis.
Acta physiologica (Oxford, England) 2010;198(3):349-54.
2010: Rafael Pineda; D Garcia-Galiano; A Roseweir; M Romero; Miguel Angel Sánchez-Garrido; F Ruiz-Pino; K Morgan; Leonor Pinilla; robert p millar; Manuel Tena-Sempere
Critical roles of kisspeptins in female puberty and preovulatory gonadotropin surges as revealed by a novel antagonist.
Endocrinology 2010;151(2):722-30.
2010: Agnete H Bentsen; Laura Ansel; Valerie Simonneaux; Manuel Tena-Sempere; Anders Juul; Jens D Mikkelsen
Maturation of kisspeptinergic neurons coincides with puberty onset in male rats.
Peptides 2010;31(2):275-83.
2010: Manuel Tena-Sempere
Kisspeptin signaling in the brain: recent developments and future challenges.
Molecular and cellular endocrinology 2010;314(2):164-9.
2010: Carmen Ruth González; J Eduardo Caminos; Rosalía Gallego; Sulay Tovar; María Jesús Vázquez; María Fernanda Garcés; Miguel Lopez; Tomás García-Caballero; Manuel Tena-Sempere; Rubén Nogueiras; Carlos Diéguez
Adiponectin receptor 2 is regulated by nutritional status, leptin and pregnancy in a tissue-specific manner.
Physiology & behavior 2010;99(1):91-9.
2010: Rafael Pineda; Enrique Aguilar; Leonor Pinilla; Manuel Tena-Sempere
Physiological roles of the kisspeptin/GPR54 system in the neuroendocrine control of reproduction.
Progress in brain research 2010;181():55-77.
2010: Manuel Tena-Sempere
Roles of kisspeptins in the control of hypothalamic-gonadotropic function: focus on sexual differentiation and puberty onset.
Endocrine development 2010;17():52-62.
2009: A Felip; Silvia Zanuy; Rafael Pineda; Leonor Pinilla; Manuel Carrillo; Manuel Tena-Sempere; Ana Gómez
Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals.
Molecular and cellular endocrinology 2009;312(1-2):61-71.
2009: Juan Roa; D Garcia-Galiano; L Varela; Miguel Angel Sánchez-Garrido; Rafael Pineda; Juan M Castellano; F Ruiz-Pino; M Romero; Enrique Aguilar; M López; Francisco Gaytan; Carlos Diéguez; Leonor Pinilla; Manuel Tena-Sempere
The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system.
Endocrinology 2009;150(11):5016-26.
2009: Ester Gutiérrez-Pascual; Jérôme Leprince; Antonio J Martínez-Fuentes; Isabelle Ségalas-Milazzo; Rafael Pineda; Juan Roa; mario duran-prado; Laure Guilhaudis; Elia Desperrois; Aurélie Lebreton; Leonor Pinilla; Marie-Christine Tonon; María M Malagón; Hubert Vaudry; Manuel Tena-Sempere; Justo P Castaño
In vivo and in vitro structure-activity relationships and structural conformation of Kisspeptin-10-related peptides.
Molecular pharmacology 2009;76(1):58-67.
2009: Juan Balasch; Francisco Fábregues; Francisco Carmona; Roser Casamitjana; Manuel Tena-Sempere
Ovarian luteinizing hormone priming preceding follicle-stimulating hormone stimulation: clinical and endocrine effects in women with long-term hypogonadotropic hypogonadism.
The Journal of clinical endocrinology and metabolism 2009;94(7):2367-73.
2009: L Pinilla; J M Castellano; M Romero; Manuel Tena-Sempere; F Gaytán; E Aguilar
Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system.
Endocrinology 2009;150(6):2889-97.
2009: Victor M Navarro; Miguel Angel Sánchez-Garrido; Juan M Castellano; Juan Roa; D García-Galiano; Rafael Pineda; Enrique Aguilar; Leonor Pinilla; Manuel Tena-Sempere
Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical periods of brain sex differentiation.
Endocrinology 2009;150(5):2359-67.
2009: Antonia K Roseweir; Alexander S Kauffman; Jeremy T Smith; Kathryn A Guerriero; Kevin Morgan; Justyna Pielecka-Fortuna; Rafael Pineda; Michelle L Gottsch; Manuel Tena-Sempere; Sue moenter; Ei Terasawa; Iain J Clarke; Robert A Steiner; Robert P Millar
Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(12):3920-9.
2009: Manuel Tena-Sempere
[Neuroendocrinology of reproduction: the kisspeptin age].
Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición 2009;56(3):103-5.
2009: Juan M Castellano; Victor M Navarro; Juan Roa; Rafael Pineda; Miguel Angel Sánchez-Garrido; D García-Galiano; Eva Vigo; Carlos Dieguez; Enrique Aguilar; Leonor Pinilla; Manuel Tena-Sempere
Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences.
Endocrinology 2009;150(2):784-94.
2009: J Roa; J M Castellano; Victor M Navarro; D J Handelsman; Leonor Pinilla; Manuel Tena-Sempere
Kisspeptins and the control of gonadotropin secretion in male and female rodents.
Peptides 2009;30(1):57-66.
2009: Justo P Castaño; Antonio J Martínez-Fuentes; Ester Gutiérrez-Pascual; Hubert Vaudry; Manuel Tena-Sempere; María M Malagón
Intracellular signaling pathways activated by kisspeptins through GPR54: do multiple signals underlie function diversity?
Peptides 2009;30(1):10-5.
2009: Manuel Tena-Sempere; Hubert Vaudry
Editorial.
Peptides 2009;30(1):1-3.
2009: Juan M Castellano; Juan Roa; Raul M Luque; Carlos Dieguez; Enrique Aguilar; Leonor Pinilla; Manuel Tena-Sempere
KiSS-1/kisspeptins and the metabolic control of reproduction: physiologic roles and putative physiopathological implications.
Peptides 2009;30(1):139-45.
2008: Manuel Tena-Sempere
Ghrelin as a pleotrophic modulator of gonadal function and reproduction.
Nature clinical practice. Endocrinology & metabolism 2008;4(12):666-74.
2008: Manuel Tena-Sempere
Timeline: the role of kisspeptins in reproductive biology.
Nature medicine 2008;14(11):1196.
2008: Juan Roa; Eva Vigo; Juan M Castellano; Francisco Gaytan; D García-Galiano; Victor M Navarro; Enrique Aguilar; F A Dijcks; Antwan Ederveen; Leonor Pinilla; P I van Noort; Manuel Tena-Sempere
Follicle-stimulating hormone responses to kisspeptin in the female rat at the preovulatory period: modulation by estrogen and progesterone receptors.
Endocrinology 2008;149(11):5783-90.
2008: Alexander V Sirotkin; Maria Chrenková; Sona Nitrayová; Peter Patras; Krzysztof Darlak; Francisco Valenzuela; Leonor Pinilla; Manuel Tena-Sempere
Effects of chronic food restriction and treatments with leptin or ghrelin on different reproductive parameters of male rats.
Peptides 2008;29(8):1362-8.
2008: J Eduardo Caminos; Rubén Nogueiras; Francisco Gaytán; Rafael Pineda; C R González; M Luz Barreiro; Justo P Castaño; María M Malagón; Leonor Pinilla; Jorma Toppari; Carlos Diéguez; Manuel Tena-Sempere
Novel expression and direct effects of adiponectin in the rat testis.
Endocrinology 2008;149(7):3390-402.
2008: Carmen Vidal; Juan Roa; Leonor Pinilla; Antonio Pellicer; Manuel Tena-Sempere
Maternal serum ghrelin levels in early IVF pregnancies: lack of prognostic value for viable pregnancy and altered post-prandial responses.
Human reproduction (Oxford, England) 2008;23(4):958-63.
2008: Juan Roa; Eva Vigo; Juan M Castellano; Francisco Gaytan; Victor M Navarro; Enrique Aguilar; F A Dijcks; Antwan Ederveen; Leonor Pinilla; P I van Noort; Manuel Tena-Sempere
Opposite roles of estrogen receptor (ER)-alpha and ERbeta in the modulation of luteinizing hormone responses to kisspeptin in the female rat: implications for the generation of the preovulatory surge.
Endocrinology 2008;149(4):1627-37.
2008: Victor M Navarro; Manuel Tena-Sempere
The KiSS-1/GPR54 system: putative target for endocrine disruption of reproduction at hypothalamic-pituitary unit?
International journal of andrology 2008;31(2):224-32.
2008: Ana Gordon; José C Garrido-Gracia; Rafaela Aguilar; Carmina Bellido; Juan A García Velasco; Yolanda Millan; Manuel Tena-Sempere; Juana Martín de las Mulas; José E Sánchez-Criado
The ovary-mediated FSH attenuation of the LH surge in the rat involves a decreased gonadotroph progesterone receptor (PR) action but not PR expression.
The Journal of endocrinology 2008;196(3):583-92.
2008: Francisca Rodríguez-Pacheco; Raul M Luque; Manuel Tena-Sempere; María M Malagón; Justo P Castaño
Ghrelin induces growth hormone secretion via a nitric oxide/cGMP signalling pathway.
Journal of neuroendocrinology 2008;20(3):406-12.
2008: Manuel Tena-Sempere
Ghrelin and reproduction: ghrelin as novel regulator of the gonadotropic axis.
Vitamins and hormones 2008;77():285-300.
2008: Juan Roa; Enrique Aguilar; Carlos Dieguez; Leonor Pinilla; Manuel Tena-Sempere
New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function.
Frontiers in neuroendocrinology 2008;29(1):48-69.
2007: Leonor Pinilla; Rafael Fernández-Fernández; Juan Roa; Juan M Castellano; Manuel Tena-Sempere; Enrique Aguilar
Selective role of neuropeptide Y receptor subtype Y2 in the control of gonadotropin secretion in the rat.
American journal of physiology. Endocrinology and metabolism 2007;293(5):E1385-92.
2007: Eva Vigo; Juan Roa; Rafael Pineda; Juan M Castellano; Victor M Navarro; Enrique Aguilar; Leonor Pinilla; Manuel Tena-Sempere
Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod.
American journal of physiology. Endocrinology and metabolism 2007;293(5):E1265-73.
2007: Raul M Luque; Rhonda D Kineman; Manuel Tena-Sempere
Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line.
Endocrinology 2007;148(10):4601-11.
2007: Marta Archanco; Javier Gómez-Ambrosi; Manuel Tena-Sempere; Gema Frühbeck; María A Burrell
Expression of leptin and adiponectin in the rat oviduct.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007;55(10):1027-37.
2007: María Gaytán; Juan M Castellano; Juan Roa; José E Sánchez-Criado; Manuel Tena-Sempere; Francisco Gaytán
Expression of KiSS-1 in rat oviduct: possible involvement in prevention of ectopic implantation?
Cell and tissue research 2007;329(3):571-9.
2007: Juan Roa; Manuel Tena-Sempere
KiSS-1 system and reproduction: comparative aspects and roles in the control of female gonadotropic axis in mammals.
General and comparative endocrinology 2007;153(1-3):132-40.
2007: E Gutiérrez-Pascual; Antonio J Martínez-Fuentes; Leonor Pinilla; Manuel Tena-Sempere; María M Malagón; Justo P Castaño
Direct pituitary effects of kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinising hormone and growth hormone secretion.
Journal of neuroendocrinology 2007;19(7):521-30.
2007: Rafael Fernández-Fernández; Manuel Tena-Sempere; Juan Roa; Juan M Castellano; Victor M Navarro; Enrique Aguilar; Leonor Pinilla
Direct stimulatory effect of ghrelin on pituitary release of LH through a nitric oxide-dependent mechanism that is modulated by estrogen.
Reproduction (Cambridge, England) 2007;133(6):1223-32.
2007: Alexander S Kauffman; Michelle L Gottsch; Juan Roa; Alisa C Byquist; Angelena Crown; Donald K Clifton; Gloria E Hoffman; Robert A Steiner; Manuel Tena-Sempere
Sexual differentiation of Kiss1 gene expression in the brain of the rat.
Endocrinology 2007;148(4):1774-83.
2007: María C García; Miguel López; Clara V Alvarez; Felipe F Casanueva; Manuel Tena-Sempere; Carlos Diéguez
Role of ghrelin in reproduction.
Reproduction (Cambridge, England) 2007;133(3):531-40.
2007: Victor M Navarro; Juan M Castellano; David García-Galiano; Manuel Tena-Sempere
Neuroendocrine factors in the initiation of puberty: the emergent role of kisspeptin.
Reviews in endocrine & metabolic disorders 2007;8(1):11-20.
2007: Eva Vigo; Juan Roa; M López; Juan M Castellano; Rafael Fernandez-Fernandez; Victor M Navarro; Rafael Pineda; Enrique Aguilar; Carlos Diéguez; Leonor Pinilla; Manuel Tena-Sempere
Neuromedin s as novel putative regulator of luteinizing hormone secretion.
Endocrinology 2007;148(2):813-23.
2007: Manuel Tena-Sempere
Roles of ghrelin and leptin in the control of reproductive function.
Neuroendocrinology 2007;86(3):229-41.
2007: Francisca Rodriguez-Pacheco; Antonio J Martinez-Fuentes; Sulay Tovar; Leonor Pinilla; Manuel Tena-Sempere; Carlos Dieguez; Justo P Castaño; Maria M Malagon
Regulation of pituitary cell function by adiponectin.
Endocrinology 2007;148(1):401-10.
2006: Juan M Castellano; Victor M Navarro; Rafael Fernández-Fernández; Juan Roa; Eva Vigo; Rafael Pineda; R A Steiner; Enrique Aguilar; Leonor Pinilla; Manuel Tena-Sempere
Effects of galanin-like peptide on luteinizing hormone secretion in the rat: sexually dimorphic responses and enhanced sensitivity at male puberty.
American journal of physiology. Endocrinology and metabolism 2006;291(6):E1281-9.
2006: Jeffrey S Davies; Nichola M Thompson; H C Christian; Leonor Pinilla; Francis J P Ebling; Manuel Tena-Sempere; Timothy Wells
Hypothalamic expression of human growth hormone induces post-pubertal hypergonadotrophism in male transgenic growth retarded rats.
Journal of neuroendocrinology 2006;18(10):719-31.
2006: Juan M Castellano; María Gaytan; Juan Roa; Eva Vigo; Victor M Navarro; Carmina Bellido; Carlos Dieguez; Enrique Aguilar; José E Sánchez-Criado; A Pellicer; Leonor Pinilla; Francisco Gaytan; Manuel Tena-Sempere
Expression of KiSS-1 in rat ovary: putative local regulator of ovulation?
Endocrinology 2006;147(10):4852-62.
2006: Juan M Castellano; Victor M Navarro; Rafael Fernández-Fernández; J P Castaño; María M Malagón; Enrique Aguilar; Carlos Dieguez; P Magni; Leonor Pinilla; Manuel Tena-Sempere
Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat.
Molecular and cellular endocrinology 2006;257-258():75-83.
2006: Juan M Castellano; Victor M Navarro; Rafael Fernández-Fernández; Juan Roa; Eva Vigo; Rafael Pineda; Carlos Dieguez; Enrique Aguilar; Leonor Pinilla; Manuel Tena-Sempere
Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats.
Diabetes 2006;55(9):2602-10.
2006: Manuel Tena-Sempere
GPR54 and kisspeptin in reproduction.
Human reproduction update 2006;12(5):631-9.
2006: Manuel Tena-Sempere
The roles of kisspeptins and G protein-coupled receptor-54 in pubertal development.
Current opinion in pediatrics 2006;18(4):442-7.
2006: Rafael Fernandez-Fernandez; A C Martini; Victor M Navarro; Juan M Castellano; Carlos Dieguez; Enrique Aguilar; Leonor Pinilla; Manuel Tena-Sempere
Novel signals for the integration of energy balance and reproduction.
Molecular and cellular endocrinology 2006;254-255():127-32.
2006: Antonio J Martínez-Fuentes; Jesús Moreno-Fernández; Rafael Vázquez-Martínez; mario duran-prado; Andrés de la Riva; Manuel Tena-Sempere; Carlos Diéguez; Luis Jiménez-Reina; Susan M Webb; Alfonso Pumar; Alfonso Leal-Cerro; Pedro Benito-López; María M Malagón; Justo P Castaño
Ghrelin is produced by and directly activates corticotrope cells from adrenocorticotropin-secreting adenomas.
The Journal of clinical endocrinology and metabolism 2006;91(6):2225-31.
2006: Juan Roa; Eva Vigo; Juan M Castellano; Victor M Navarro; Rafael Fernández-Fernández; Felipe F Casanueva; Carlos Dieguez; Enrique Aguilar; Leonor Pinilla; Manuel Tena-Sempere
Hypothalamic expression of KiSS-1 system and gonadotropin-releasing effects of kisspeptin in different reproductive states of the female Rat.
Endocrinology 2006;147(6):2864-78.
2006: Sulay Tovar; María Jesús Vázquez; Victor M Navarro; Rafael Fernández-Fernández; Juan M Castellano; Eva Vigo; Juan Roa; Felipe F Casanueva; Enrique Aguilar; Leonor Pinilla; Carlos Dieguez; Manuel Tena-Sempere
Effects of single or repeated intravenous administration of kisspeptin upon dynamic LH secretion in conscious male rats.
Endocrinology 2006;147(6):2696-704.
2006: Leonor Pinilla; Rafael Fernández-Fernández; Eva Vigo; Victor M Navarro; Juan Roa; Juan M Castellano; Rafael Pineda; Manuel Tena-Sempere; Enrique Aguilar
Stimulatory effect of PYY-(3-36) on gonadotropin secretion is potentiated in fasted rats.
American journal of physiology. Endocrinology and metabolism 2006;290(6):E1162-71.
2006: Victor M Navarro; Rubén Nogueiras; Leonor Pinilla; Enrique Aguilar; N Chartrel; Carlos Dieguez; Rafael Fernández-Fernández; O Le Marec; J Leprince; Sulay Tovar; Hubert Vaudry; Eva Vigo; Manuel Tena-Sempere
Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as putative regulator of the gonadotropic axis.
The Journal of physiology 2006;573(Pt 1):237-49.
2006: A C Martini; Rafael Fernández-Fernández; Sulay Tovar; Victor M Navarro; Eva Vigo; MJ Vazquez; Jeffrey S Davies; Nichola M Thompson; Enrique Aguilar; Leonor Pinilla; Timothy Wells; Carlos Dieguez; Manuel Tena-Sempere
Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats.
Endocrinology 2006;147(5):2374-82.
2006: Henrik Leffers; Victor M Navarro; John E Nielsen; A Mayen; Leonor Pinilla; M Dalgaard; Maria M Malagon; J P Castaño; Niels E Skakkebaek; Enrique Aguilar; Manuel Tena-Sempere
Increased expression of alpha- and beta-globin mRNAs at the pituitary following exposure to estrogen during the critical period of neonatal sex differentiation in the rat.
The Journal of steroid biochemistry and molecular biology 2006;99(1):33-43.
2006: Esteban Lavaque; Aurora Mayen; Iñigo Azcoitia; Manuel Tena-Sempere; Luis M Garcia-Segura
Sex differences, developmental changes, response to injury and cAMP regulation of the mRNA levels of steroidogenic acute regulatory protein, cytochrome p450scc, and aromatase in the olivocerebellar system.
Journal of neurobiology 2006;66(3):308-18.
2006: José E Sánchez-Criado; J Martín de las Mulas; Carmina Bellido; Victor M Navarro; Rafaela Aguilar; José C Garrido-Gracia; María M Malagón; Manuel Tena-Sempere; Alfonso Blanco
Gonadotropin-secreting cells in ovariectomized rats treated with different oestrogen receptor ligands: a modulatory role for ERbeta in the gonadotrope?
The Journal of endocrinology 2006;188(2):167-77.
2006: Manuel Tena-Sempere
KiSS-1 and reproduction: focus on its role in the metabolic regulation of fertility.
Neuroendocrinology 2006;83(5-6):275-81.
2005: Enrique Aguilar; Manuel Tena-Sempere; Leonor Pinilla
Role of excitatory amino acids in the control of growth hormone secretion.
Endocrine 2005;28(3):295-302.
2005: M Luz Barreiro; Rafael Pineda; Francisco Gaytan; Marta Archanco; M A Burrell; Juan M Castellano; H Hakovirta; M Nurmio; Leonor Pinilla; Enrique Aguilar; Jorma Toppari; Carlos Dieguez; Manuel Tena-Sempere
Pattern of orexin expression and direct biological actions of orexin-a in rat testis.
Endocrinology 2005;146(12):5164-75.
2005: Manuel Tena-Sempere
Hypothalamic KiSS-1: the missing link in gonadotropin feedback control?
Endocrinology 2005;146(9):3683-5.
2005: Raul M Luque; Francisca Rodríguez-Pacheco; Manuel Tena-Sempere; Francisco Gracia-Navarro; María M Malagón; Justo P Castaño
Differential contribution of nitric oxide and cGMP to the stimulatory effects of growth hormone-releasing hormone and low-concentration somatostatin on growth hormone release from somatotrophs.
Journal of neuroendocrinology 2005;17(9):577-82.
2005: Juan M Castellano; Victor M Navarro; Rafael Fernández-Fernández; Rubén Nogueiras; Sulay Tovar; Juan Roa; MJ Vazquez; Eva Vigo; Felipe F Casanueva; Enrique Aguilar; Leonor Pinilla; Carlos Dieguez; Manuel Tena-Sempere
Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition.
Endocrinology 2005;146(9):3917-25.
2005: Rafael Fernández-Fernández; Victor M Navarro; M Luz Barreiro; Eva Vigo; Sulay Tovar; A V Sirotkin; Felipe F Casanueva; Enrique Aguilar; Carlos Dieguez; Leonor Pinilla; Manuel Tena-Sempere
Effects of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat.
Endocrinology 2005;146(7):3018-25.
2005: Rubén Nogueiras; J Eduardo Caminos; Rosalía Gallego; Kawtar Raghay; Susana B Bravo; Sulay Tovar; Celia M Pombo; Miguel López; Manuel Tena-Sempere; Tomás García-Caballero; Carlos Diéguez
Regulation of peroxisome proliferator activated receptor-gamma in rat pituitary.
Journal of neuroendocrinology 2005;17(5):292-7.
2005: Manuel Tena-Sempere
Exploring the role of ghrelin as novel regulator of gonadal function.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2005;15(2):83-8.
2005: Victor M Navarro; Juan M Castellano; Rafael Fernández-Fernández; Sulay Tovar; Juan Roa; A Mayen; M Luz Barreiro; Felipe F Casanueva; Enrique Aguilar; Carlos Dieguez; Leonor Pinilla; Manuel Tena-Sempere
Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat.
Endocrinology 2005;146(4):1689-97.
2005: Francisco Gaytan; Concepción Morales; M Luz Barreiro; P Jeffery; Lisa K Chopin; Adrian C Herington; Felipe F Casanueva; Enrique Aguilar; Carlos Dieguez; Manuel Tena-Sempere
Expression of growth hormone secretagogue receptor type 1a, the functional ghrelin receptor, in human ovarian surface epithelium, mullerian duct derivatives, and ovarian tumors.
The Journal of clinical endocrinology and metabolism 2005;90(3):1798-804.
2005: Rafael Fernandez-Fernandez; Enrique Aguilar; Manuel Tena-Sempere; Leonor Pinilla
Effects of polypeptide YY(3-36) upon luteinizing hormone-releasing hormone and gonadotropin secretion in prepubertal rats: in vivo and in vitro studies.
Endocrinology 2005;146(3):1403-10.
2005: Rafael Fernández-Fernández; Manuel Tena-Sempere; Victor M Navarro; M Luz Barreiro; Juan M Castellano; Enrique Aguilar; Leonor Pinilla
Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies.
Neuroendocrinology 2005;82(5-6):245-55.
2005: Manuel Tena-Sempere
Ghrelin: novel regulator of gonadal function.
Journal of endocrinological investigation 2005;28(5 Suppl):26-9.
2005: Victor M Navarro; Juan M Castellano; Rafael Fernández-Fernández; Sulay Tovar; Juan Roa; A Mayen; Rubén Nogueiras; MJ Vazquez; M Luz Barreiro; P Magni; Enrique Aguilar; Carlos Dieguez; Leonor Pinilla; Manuel Tena-Sempere
Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54.
Endocrinology 2005;146(1):156-63.
2004: Victor M Navarro; Rafael Fernández-Fernández; Juan M Castellano; Juan Roa; A Mayen; M Luz Barreiro; Francisco Gaytan; Enrique Aguilar; Leonor Pinilla; Carlos Dieguez; Manuel Tena-Sempere
Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54.
The Journal of physiology 2004;561(Pt 2):379-86.
2004: M Luz Barreiro; Francisco Gaytan; Juan M Castellano; Janne S Suominen; Juan Roa; María Gaytan; Enrique Aguilar; Carlos Dieguez; Jorma Toppari; Manuel Tena-Sempere
Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testis.
Endocrinology 2004;145(11):4825-34.
2004: M Luz Barreiro; Manuel Tena-Sempere
Ghrelin and reproduction: a novel signal linking energy status and fertility?
Molecular and cellular endocrinology 2004;226(1-2):1-9.
2004: Victor M Navarro; Juan M Castellano; Rafael Fernández-Fernández; M Luz Barreiro; Juan Roa; Jose E Sanchez-Criado; Enrique Aguilar; Carlos Dieguez; Leonor Pinilla; Manuel Tena-Sempere
Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide.
Endocrinology 2004;145(10):4565-74.
2004: Enrique Aguilar; Rafael Fernandez-Fernandez; Manuel Tena-Sempere; Leonor Pinilla
Effects of peptide YY(3-36) on PRL secretion: pituitary and extra-pituitary actions in the rat.
Peptides 2004;25(7):1147-52.
2004: Rubén Nogueiras; M Luz Barreiro; J Eduardo Caminos; Francisco Gaytán; Janne S Suominen; Victor M Navarro; Felipe F Casanueva; Enrique Aguilar; Jorma Toppari; Carlos Diéguez; Manuel Tena-Sempere
Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors.
Journal of cell science 2004;117(Pt 15):3247-57.
2004: Rafael Fernández-Fernández; Manuel Tena-Sempere; Enrique Aguilar; Leonor Pinilla
Ghrelin effects on gonadotropin secretion in male and female rats.
Neuroscience letters 2004;362(2):103-7.
2004: M Luz Barreiro; Rafael Pineda; Victor M Navarro; M Lopez; Janne S Suominen; Leonor Pinilla; R Señaris; Jorma Toppari; Enrique Aguilar; Carlos Diéguez; Manuel Tena-Sempere
Orexin 1 receptor messenger ribonucleic acid expression and stimulation of testosterone secretion by orexin-A in rat testis.
Endocrinology 2004;145(5):2297-306.
2004: Manuel Tena-Sempere; Enrique Aguilar; Rafael Fernandez-Fernandez; Leonor Pinilla
Ghrelin inhibits prolactin secretion in prepubertal rats.
Neuroendocrinology 2004;79(3):133-41.
2004: Manuel Tena-Sempere; M Luz Barreiro; Enrique Aguilar; Leonor Pinilla
Mechanisms for altered reproductive function in female rats following neonatal administration of raloxifene.
European journal of endocrinology / European Federation of Endocrine Societies 2004;150(3):397-403.
2004: Manuel Tena-Sempere; Victor M Navarro; A Mayen; Carmina Bellido; José E Sánchez-Criado
Regulation of estrogen receptor (ER) isoform messenger RNA expression by different ER ligands in female rat pituitary.
Biology of reproduction 2004;70(3):671-8.
2004: José E Sánchez-Criado; Juana Martín de las Mulas; Carmina Bellido; Manuel Tena-Sempere; Rafaela Aguilar; Alfonso Blanco
Biological role of pituitary estrogen receptors ERalpha and ERbeta on progesterone receptor expression and action and on gonadotropin and prolactin secretion in the rat.
Neuroendocrinology 2004;79(5):247-58.
2004: Francisco Gaytan; M Luz Barreiro; J Eduardo Caminos; Lisa K Chopin; Adrian C Herington; Concepción Morales; Leonor Pinilla; R Paniagua; M Nistal; Felipe F Casanueva; Enrique Aguilar; Carlos Diéguez; Manuel Tena-Sempere
Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors.
The Journal of clinical endocrinology and metabolism 2004;89(1):400-9.
2003: Carmina Bellido; Juana Martín de las Mulas; Manuel Tena-Sempere; Rafaela Aguilar; Rafael Alonso; José E Sánchez-Criado
Tamoxifen induces gonadotropin-releasing hormone self-priming through an estrogen-dependent progesterone receptor expression in the gonadotrope of the rat.
Neuroendocrinology 2003;77(6):425-35.
2003: M Luz Barreiro; Janne S Suominen; Francisco Gaytán; Leonor Pinilla; Lisa K Chopin; Felipe F Casanueva; Carlos Diéguez; Enrique Aguilar; Jorma Toppari; Manuel Tena-Sempere
Developmental, stage-specific, and hormonally regulated expression of growth hormone secretagogue receptor messenger RNA in rat testis.
Biology of reproduction 2003;68(5):1631-40.
2003: J Eduardo Caminos; Manuel Tena-Sempere; Francisco Gaytán; Jose E Sanchez-Criado; M Luz Barreiro; Rubén Nogueiras; Felipe F Casanueva; Enrique Aguilar; Carlos Diéguez
Expression of ghrelin in the cyclic and pregnant rat ovary.
Endocrinology 2003;144(4):1594-602.
2003: Leonor Pinilla; M Luz Barreiro; Manuel Tena-Sempere; Enrique Aguilar
Role of ghrelin in the control of growth hormone secretion in prepubertal rats: interactions with excitatory amino acids.
Neuroendocrinology 2003;77(2):83-90.
2003: Francisco Gaytan; M Luz Barreiro; Lisa K Chopin; Adrian C Herington; Concepción Morales; Leonor Pinilla; Felipe F Casanueva; Enrique Aguilar; Carlos Diéguez; Manuel Tena-Sempere
Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary.
The Journal of clinical endocrinology and metabolism 2003;88(2):879-87.
2003: Leonor Pinilla; Lucas C Gonzalez; Manuel Tena-Sempere; Enrique Aguilar
5-HT1 and 5-HT2 receptor activation reduces N-methyl-D-aspartate (NMDA)-stimulated LH secretion in prepubertal male and female rats.
European journal of endocrinology / European Federation of Endocrine Societies 2003;148(1):121-7.
2002: M Luz Barreiro; Francisco Gaytán; J Eduardo Caminos; Leonor Pinilla; Felipe F Casanueva; Enrique Aguilar; Carlos Diéguez; Manuel Tena-Sempere
Cellular location and hormonal regulation of ghrelin expression in rat testis.
Biology of reproduction 2002;67(6):1768-76.
2002: M Luz Barreiro; Leonor Pinilla; Enrique Aguilar; Manuel Tena-Sempere
Expression and homologous regulation of GH secretagogue receptor mRNA in rat adrenal gland.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(5):677-88.
2002: Leonor Pinilla; M Luz Barreiro; Manuel Tena-Sempere; Enrique Aguilar
Raloxifene effects upon the neuronal system controlling sexual receptivity in female rats.
Neuroscience letters 2002;329(3):285-8.
2002: Leonor Pinilla; M Luz Barreiro; Lucas C Gonzalez; Manuel Tena-Sempere; Enrique Aguilar
Comparative effects of testosterone propionate, oestradiol benzoate, ICI 182,780, tamoxifen and raloxifene on hypothalamic differentiation in the female rat.
The Journal of endocrinology 2002;172(3):441-8.
2002: Manuel Tena-Sempere; M Luz Barreiro
Leptin in male reproduction: the testis paradigm.
Molecular and cellular endocrinology 2002;188(1-2):9-13.
2002: Leonor Pinilla; LC González; Manuel Tena-Sempere; Enrique Aguilar
Interactions between GABAergic and aminoacidergic pathways in the control of gonadotropin and GH secretion in pre-pubertal female rats.
Journal of endocrinological investigation 2002;25(2):96-100.
2002: Manuel Tena-Sempere; M Luz Barreiro; LC González; Francisco Gaytán; Fu-Ping Zhang; J Eduardo Caminos; Leonor Pinilla; Felipe F Casanueva; Carlos Diéguez; Enrique Aguilar
Novel expression and functional role of ghrelin in rat testis.
Endocrinology 2002;143(2):717-25.
2001: Manuel Tena-Sempere; M Luz Barreiro; LC González; Leonor Pinilla; Enrique Aguilar
Differential neonatal imprinting and regulation by estrogen of estrogen receptor subtypes alpha and beta and of the truncated estrogen receptor product (TERP-1) mRNA expression in the male rat pituitary.
Neuroendocrinology 2001;74(5):347-58.
2001: Leonor Pinilla; Lucas C Gonzalez; Manuel Tena-Sempere; Enrique Aguilar
Evidence for an estrogen-like action of raloxifene upon the hypothalamic-pituitary unit: raloxifene inhibits luteinizing hormone secretion and stimulates prolactin secretion in ovariectomized female rats.
Neuroscience letters 2001;311(3):149-52.
2001: Leonor Pinilla; LC González; Manuel Tena-Sempere; Enrique Aguilar
Interactions between serotoninergic and aminoacidergic pathways in the control of PRL secretion in prepubertal male rats.
Journal of physiology and biochemistry 2001;57(3):237-44.
2001: Manuel Tena-Sempere; Pulak R Manna; Fu-Ping Zhang; Leonor Pinilla; LC González; Carlos Diéguez; Ilpo Huhtaniemi; Enrique Aguilar
Molecular mechanisms of leptin action in adult rat testis: potential targets for leptin-induced inhibition of steroidogenesis and pattern of leptin receptor messenger ribonucleic acid expression.
The Journal of endocrinology 2001;170(2):413-23.
2001: Faraj El-Gehani; Manuel Tena-Sempere; H Ruskoaho; Ilpo Huhtaniemi
Natriuretic peptides stimulate steroidogenesis in the fetal rat testis.
Biology of reproduction 2001;65(2):595-600.
2001: Leonor Pinilla; LC González; Francisco Gaytán; Manuel Tena-Sempere; Enrique Aguilar
Oestrogenic effects of neonatal administration of raloxifene on hypothalamic-pituitary-gonadal axis in male and female rats.
Reproduction (Cambridge, England) 2001;121(6):915-24.
2001: Leonor Pinilla; Lucas C Gonzalez; Manuel Tena-Sempere; Enrique Aguilar
5-HT1 and 5-HT2 receptor agonists blunt +/- -alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-stimulated GH secretion in prepubertal male rats.
European journal of endocrinology / European Federation of Endocrine Societies 2001;144(5):535-41.
2001: Manuel Tena-Sempere; Leonor Pinilla; Fu-Ping Zhang; LC González; Ilpo Huhtaniemi; Felipe F Casanueva; C Dieguez; Enrique Aguilar
Developmental and hormonal regulation of leptin receptor (Ob-R) messenger ribonucleic acid expression in rat testis.
Biology of reproduction 2001;64(2):634-43.
2001: Leonor Pinilla; LC González; Manuel Tena-Sempere; C Bellido; Enrique Aguilar
Effects of systemic blockade of nitric oxide synthases on pulsatile LH, prolactin, and GH secretion in adult male rats.
Hormone research 2001;55(5):229-35.
2001: Leonor Pinilla; Lucas C Gonzalez; Manuel Tena-Sempere; Enrique Aguilar
Cross-talk between excitatory and inhibitory amino acids in the regulation of growth hormone secretion in neonatal rats.
Neuroendocrinology 2001;73(1):62-7.
2001: Manuel Tena-Sempere; LC González; Leonor Pinilla; Ilpo Huhtaniemi; Enrique Aguilar
Neonatal imprinting and regulation of estrogen receptor alpha and beta mRNA expression by estrogen in the pituitary and hypothalamus of the male rat.
Neuroendocrinology 2001;73(1):12-25.
2001: Pulak R Manna; Jukka Kero; Manuel Tena-Sempere; Pirjo Pakarinen; D M Stocco; Ilpo T Huhtaniemi
Assessment of mechanisms of thyroid hormone action in mouse Leydig cells: regulation of the steroidogenic acute regulatory protein, steroidogenesis, and luteinizing hormone receptor function.
Endocrinology 2001;142(1):319-31.
2000: Leonor Pinilla; L Gonzalez; Manuel Tena-Sempere; Enrique Aguilar
Activation of AMPA receptors inhibits prolactin and estradiol secretion and delays the onset of puberty in female rats.
The Journal of steroid biochemistry and molecular biology 2000;75(4-5):277-81.
2000: Manuel Tena-Sempere; Leonor Pinilla; LC González; Felipe F Casanueva; Carlos Diéguez; Enrique Aguilar
Homologous and heterologous down-regulation of leptin receptor messenger ribonucleic acid in rat adrenal gland.
The Journal of endocrinology 2000;167(3):479-86.
2000: Faraj El-Gehani; Manuel Tena-Sempere; Ilpo Huhtaniemi
Evidence that pituitary adenylate cyclase-activating polypeptide is a potent regulator of fetal rat testicular steroidogenesis.
Biology of reproduction 2000;63(5):1482-9.
2000: LC González; Leonor Pinilla; Manuel Tena-Sempere; Enrique Aguilar
Regulation of prolactin secretion by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in male rats.
The Journal of endocrinology 2000;166(3):669-75.
2000: Manuel Tena-Sempere; J Navarro; Leonor Pinilla; LC González; Ilpo Huhtaniemi; Enrique Aguilar
Neonatal exposure to estrogen differentially alters estrogen receptor alpha and beta mRNA expression in rat testis during postnatal development.
The Journal of endocrinology 2000;165(2):345-57.
2000: Manuel Tena-Sempere; Leonor Pinilla; LC González; J Navarro; Carlos Diéguez; Felipe F Casanueva; Enrique Aguilar
In vitro pituitary and testicular effects of the leptin-related synthetic peptide leptin(116-130) amide involve actions both similar to and distinct from those of the native leptin molecule in the adult rat.
European journal of endocrinology / European Federation of Endocrine Societies 2000;142(4):406-10.
2000: Manuel Tena-Sempere; Leonor Pinilla; LC González; Enrique Aguilar
Regulation of growth hormone (GH) secretion by different glutamate receptor subtypes in the rat.
Amino acids 2000;18(1):1-16.
2000: Lucas C Gonzalez; Leonor Pinilla; Manuel Tena-Sempere; C Dieguez; F F Casanueva; Enrique Aguilar
Effect of acute immunoneutralization of endogenous leptin on prolactin and LH secretion during the afternoon of pro-oestrus or in steroid-treated ovariectomized female rats.
Journal of reproduction and fertility 2000;118(1):39-45.
1999: Manuel Tena-Sempere; Jukka Kero; Antti Rannikko; Wei Yan; Ilpo Huhtaniemi
The pattern of inhibin/activin alpha- and betaB-subunit messenger ribonucleic acid expression in rat testis after selective Leydig cell destruction by ethylene dimethane sulfonate.
Endocrinology 1999;140(12):5761-70.
1999: Lucas C Gonzalez; Leonor Pinilla; Manuel Tena-Sempere; Enrique Aguilar
Leptin(116-130) stimulates prolactin and luteinizing hormone secretion in fasted adult male rats.
Neuroendocrinology 1999;70(3):213-20.
1999: LC González; Leonor Pinilla; Manuel Tena-Sempere; Enrique Aguilar
Role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in the control of prolactin, growth hormone and gonadotropin secretion in prepubertal rats.
The Journal of endocrinology 1999;162(3):417-24.
1999: Manuel Tena-Sempere; Pulak R Manna; Ilpo Huhtaniemi
Molecular cloning of the mouse follicle-stimulating hormone receptor complementary deoxyribonucleic acid: functional expression of alternatively spliced variants and receptor inactivation by a C566T transition in exon 7 of the coding sequence.
Biology of reproduction 1999;60(6):1515-27.
1999: Leonor Pinilla; Manuel Tena-Sempere; D Gonzalez; Enrique Aguilar
The role of nitric oxide in the control of basal and LHRH-stimulated LH secretion.
Journal of endocrinological investigation 1999;22(5):340-8.
1999: Manuel Tena-Sempere; Leonor Pinilla; LC González; Carlos Diéguez; Felipe F Casanueva; Enrique Aguilar
Leptin inhibits testosterone secretion from adult rat testis in vitro.
The Journal of endocrinology 1999;161(2):211-8.
1999: Manuel Tena-Sempere; Jukka Kero; Antti Rannikko; Ilpo Huhtaniemi
Experimental cryptorchidism induces a change in the pattern of expression of LH receptor mRNA in rat testis after selective Leydig cell destruction by ethylene dimethane sulfonate.
The Journal of endocrinology 1999;161(1):131-41.
1999: LC González; Leonor Pinilla; Manuel Tena-Sempere; Enrique Aguilar
Regulation of growth hormone secretion by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in infantile, prepubertal, and adult male rats.
Endocrinology 1999;140(3):1279-84.
1999: Pulak R Manna; Manuel Tena-Sempere; Ilpo T Huhtaniemi
Molecular mechanisms of thyroid hormone-stimulated steroidogenesis in mouse leydig tumor cells. Involvement of the steroidogenic acute regulatory (StAR) protein.
The Journal of biological chemistry 1999;274(9):5909-18.
1999: Leonor Pinilla; Manuel Tena-Sempere; Enrique Aguilar
Nitric oxide stimulates growth hormone secretion in vitro through a calcium- and cyclic guanosine monophosphate-independent mechanism.
Hormone research 1999;51(5):242-7.
1999: Leonor Pinilla; L Gonzalez; Manuel Tena-Sempere; Carlos Dieguez; Enrique Aguilar
Gonadal and age-related influences on NMDA-induced growth hormone secretion in male rats.
Neuroendocrinology 1999;69(1):11-9.
1998: Leonor Pinilla; LC González; Manuel Tena-Sempere; Enrique Aguilar
Nitro(w)-arginine methyl ester treatment delayed the onset of puberty in female rats.
Journal of physiology and biochemistry 1998;54(3):135-9.
1998: Leonor Pinilla; D González; Manuel Tena-Sempere; Enrique Aguilar
Nitric oxide (NO) stimulates gonadotropin secretion in vitro through a calcium-dependent, cGMP-independent mechanism.
Neuroendocrinology 1998;68(3):180-6.
1998: Leonor Pinilla; Manuel Tena-Sempere; Enrique Aguilar
Sexual differences in the role of kainate receptors in controlling gonadotrophin secretion in prepubertal rats.
Journal of reproduction and fertility 1998;113(2):269-73.
1998: Faraj El-Gehani; Manuel Tena-Sempere; Ilpo Huhtaniemi
Vasoactive intestinal peptide stimulates testosterone production by cultured fetal rat testicular cells.
Molecular and cellular endocrinology 1998;140(1-2):175-8.
1998: Leonor Pinilla; Manuel Tena-Sempere; Enrique Aguilar
Role of excitatory amino acid pathways in control of gonadotrophin secretion in adult female rats sterilized by neonatal administration of oestradiol or testosterone.
Journal of reproduction and fertility 1998;113(1):53-9.
1998: Leonor Pinilla; Manuel Tena-Sempere; Rafaela Aguilar; Enrique Aguilar
Effects of N-methyl-D-aspartic acid and kainic acid on prolactin secretion in hyper- and hypoprolactinaemic conditions.
European journal of endocrinology / European Federation of Endocrine Societies 1998;138(4):460-6.
1998: Faraj El-Gehani; Manuel Tena-Sempere; Ilpo Huhtaniemi
Vasoactive intestinal peptide is an important endocrine regulatory factor of fetal rat testicular steroidogenesis.
Endocrinology 1998;139(4):1474-80.
1997: Manuel Tena-Sempere; Antti Rannikko; Jukka Kero; Fu-Ping Zhang; Ilpo T Huhtaniemi
Molecular mechanisms of reappearance of luteinizing hormone receptor expression and function in rat testis after selective Leydig cell destruction by ethylene dimethane sulfonate.
Endocrinology 1997;138(8):3340-8.
1997: Leonor Pinilla; Manuel Tena-Sempere; Enrique Aguilar
Role of serotoninergic receptors in gonadotropin secretion in male rats.
Journal of endocrinological investigation 1997;20(7):410-6.
1997: Enrique Aguilar; Manuel Tena-Sempere; Rafaela Aguilar; D González; Leonor Pinilla
Interactions between N-methyl-D-aspartate, nitric oxide and serotonin in the control of prolactin secretion in prepubertal male rats.
European journal of endocrinology / European Federation of Endocrine Societies 1997;137(1):99-106.
1996: Leonor Pinilla; D Gonzalez; Manuel Tena-Sempere; Rafaela Aguilar; Enrique Aguilar
Mechanisms of inhibitory action of kainic acid on prolactin secretion in male rats.
The Journal of endocrinology 1996;151(1):159-67.
1996: Leonor Pinilla; D González; Manuel Tena-Sempere; Rafaela Aguilar; Enrique Aguilar
Effects of N-methyl-D-aspartate and kainic acid on prolactin secretion in prepubertal female rats.
European journal of endocrinology / European Federation of Endocrine Societies 1996;135(4):464-8.
1996: Manuel Tena-Sempere; Leonor Pinilla; E Aguilar
The pattern of testosterone replacement influences the recovery of the stimulatory effect of clonidine on growth hormone (GH) secretion in orchidectomized rats.
The Journal of steroid biochemistry and molecular biology 1996;58(5-6):533-8.
1996: Manuel Tena-Sempere; Leonor Pinilla; D González; Enrique Aguilar
Involvement of endogneous nitric oxide in the control of pituitary responsiveness to different elicitors of growth hormone release in prepubertal rats.
Neuroendocrinology 1996;64(2):146-52.
1996: Leonor Pinilla; Manuel Tena-Sempere; D Gonzalez; Enrique Aguilar
Positive role of non-N-methyl-D-aspartate receptors in the control of growth hormone secretion in male rats.
Journal of endocrinological investigation 1996;19(6):353-8.
1996: Enrique Aguilar; Manuel Tena-Sempere; D Gonzalez; Leonor Pinilla
Control of gonadotropin secretion in prepubertal male rats by excitatory amino acids.
Andrologia 1996;28(3):163-9.
1996: Manuel Tena-Sempere; Leonor Pinilla; Enrique Aguilar
In vitro pituitary GH secretion after GHRH, forskolin, dibutyryl cyclic-adenosine 3',5'-monophosphate and phorbol 12-myristate 13-acetate stimulation in long-term orchidectomized rats.
Journal of molecular endocrinology 1996;16(1):81-8.
1995: Leonor Pinilla; Manuel Tena-Sempere; Enrique Aguilar
The role of excitatory amino acid pathways in the control of pituitary function in neonatally oestrogenized male rats.
The Journal of endocrinology 1995;147(1):51-7.
1995: Leonor Pinilla; Manuel Tena-Sempere; D Gonzalez; Enrique Aguilar
Mechanisms of altered LH secretion in neonatally oestrogenized male rats.
The Journal of endocrinology 1995;147(1):43-50.
1995: Manuel Tena-Sempere; Leonor Pinilla; Enrique Aguilar
Orchidectomy selectively increases follicle-stimulating hormone secretion in gonadotropin-releasing hormone antagonist-treated male rats.
European journal of endocrinology / European Federation of Endocrine Societies 1995;132(3):357-62.
1994: Enrique Aguilar; A Ranchal; Manuel Tena-Sempere; Leonor Pinilla
Serotoninergic control of prolactin secretion in prepubertal male rats.
European journal of endocrinology / European Federation of Endocrine Societies 1994;131(5):547-54.
1994: Manuel Tena-Sempere; Fu-Ping Zhang; Ilpo Huhtaniemi
Persistent expression of a truncated form of the luteinizing hormone receptor messenger ribonucleic acid in the rat testis after selective Leydig cell destruction by ethylene dimethane sulfonate.
Endocrinology 1994;135(3):1018-24.
1994: Leonor Pinilla; P Garnelo; Manuel Tena-Sempere; Francisco Gaytan; Enrique Aguilar
Mechanisms of reproductive deficiency in male rats treated neonatally with a gonadotrophin-releasing hormone antagonist.
The Journal of endocrinology 1994;142(3):517-25.
1993: Manuel Tena-Sempere; Leonor Pinilla; Enrique Aguilar
Follicle-stimulating hormone and luteinizing hormone secretion in male rats orchidectomized or injected with ethylene dimethane sulfonate.
Endocrinology 1993;133(3):1173-81.
1993: Enrique Aguilar; Leonor Pinilla; Manuel Tena-Sempere
Growth hormone-releasing hormone-induced growth hormone secretion in adult rats orchidectomized or injected with ethylene dimethane sulphonate.
Neuroendocrinology 1993;57(1):132-4.
1992: Enrique Aguilar; M L Rodriguez Padilla; C Bellido; Manuel Tena-Sempere; Leonor Pinilla
Changes in follicle-stimulating hormone secretion in spontaneously hypertensive rats.
Neuroendocrinology 1992;56(1):85-93.
1992: Enrique Aguilar; Manuel Tena-Sempere; Leonor Pinilla
5-alpha androstane diol stimulates the pituitary growth hormone responsiveness to growth hormone releasing hormone more effectively than testosterone or dihydrotestosterone in rats.
Acta endocrinologica 1992;126(2):162-6.