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Daniel Tenen

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Robert S Welner; Min Ye; Hong Zhang; K Disnika Senali Abayratna Wansa; Koichi Akashi; Giovanni Amabile; Christian Bach; Deepak Bararia; Touati Benoukraf; Akos Czibere; Christopher J Hetherington; Tadafumi Iino; Daniel G Tenen
C/EBPα is required for development of dendritic cell progenitors.
Min Ye; Hong Zhang; Junyan Zhang; Pu Zhang; Meritxell Alberich-Jordà; Giovanni Amabile; Akira Kawasaki; Elena Levantini; Philipp B Staber; Henry Yang; Daniel G Tenen
C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence.
Philipp B Staber; Robert S Welner; Henry Yang; Min Ye; Hong Zhang; Junyan Zhang; Pu Zhang; Meritxell Alberich-Jordà; Christian Bach; Boris A Bartholdy; Berthold Göttgens; Gerald Hoefler; Gang Huang; Marc Kerenyi; Mathias Leddin; Sanghoon Lee; Felicia Ng; César Nombela-Arrieta; Stuart H Orkin; Frank Rosenbauer; Leslie E Silberstein; Daniel G Tenen
Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.

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All Publications

2013: Robert S Welner; Min Ye; Hong Zhang; K Disnika Senali Abayratna Wansa; Koichi Akashi; Giovanni Amabile; Christian Bach; Deepak Bararia; Touati Benoukraf; Akos Czibere; Christopher J Hetherington; Tadafumi Iino; Daniel G Tenen
C/EBPα is required for development of dendritic cell progenitors.
Blood 2013;121(20):4073-81.
2013: Min Ye; Hong Zhang; Junyan Zhang; Pu Zhang; Meritxell Alberich-Jordà; Giovanni Amabile; Akira Kawasaki; Elena Levantini; Philipp B Staber; Henry Yang; Daniel G Tenen
C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence.
Nature cell biology 2013;15(4):385-94.
2013: Philipp B Staber; Robert S Welner; Henry Yang; Min Ye; Hong Zhang; Junyan Zhang; Pu Zhang; Meritxell Alberich-Jordà; Christian Bach; Boris A Bartholdy; Berthold Göttgens; Gerald Hoefler; Gang Huang; Marc Kerenyi; Mathias Leddin; Sanghoon Lee; Felicia Ng; César Nombela-Arrieta; Stuart H Orkin; Frank Rosenbauer; Leslie E Silberstein; Daniel G Tenen
Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.
Molecular cell 2013;49(5):934-46.
2013: Chong Gao; Ha-won Jeong; Hongbo R Luo; Hiro Tatetsu; Daniel G Tenen; Kol Jia Yong; James E Bradner; Todor Dimitrov; Li Chai
Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex.
Blood 2013;121(8):1413-21.
2013: Giovanni Amabile; Anna Morena D'Alise; Annalisa Di Ruscio; Alexander K Ebralidze; Konstantin Khrapko; Olivier Kocher; Yevgenya Kraytsberg; Donna Neuberg; César Nombela-Arrieta; Leslie E Silberstein; Robert S Welner; Min Ye; Daniel G Tenen
In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.
Blood 2013;121(8):1255-64.
2013: Leilei Chen; Raymond Kwok Kei Chow; Li Fu; Tim Hon Man Chan; Kar Lok Kong; Dora Lai-Wan Kwong; Yan Li; Yan Li; Chi Ho Lin; Ming Liu; Chung-Mau Lo; Si Lok; Kwan Man; Lihua Qi; Yangyang Song; Daniel G Tenen; Amy Hin Yan Tong; Yun-Fei Yuan; Na Zhang; Xin-Yuan Guan
Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma.
Nature medicine 2013;19(2):209-16.
2013: Hideyo Hirai; Gang Huang; Jiro Imanishi; Naoka Kamio; Nobuhiko Kimura; Akiko Matsusue; Shinpei Ogino; Sakiko Satake; Daniel G Tenen; Eishi Ashihara; Taira Maekawa
Cyclic AMP responsive element binding proteins are involved in 'emergency' granulopoiesis through the upregulation of CCAAT/enhancer binding protein β.
PloS one 2013;8(1):e54862.
2012: Meritxell Alberich-Jordà; Giovanni Amabile; Roberto Avellino; Martin Balastik; Ruud Delwel; Annalisa DiRuscio; Alexander K Ebralidze; Maria E Figueroa; Irene Lowers; Ari Melnick; Hanna S Radomska; Clara Shapiro-Koss; Peter J M Valk; Bas Wouters; Min Ye; Hong Zhang; Junyan Zhang; Annalisa Di Ruscio; Daniel G Tenen
C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia.
The Journal of clinical investigation 2012;122(12):4490-504.
2012: Monika Lichtinger; Michael Lie-A-Ling; Dorothee Müller; Laura Noailles; Daniel G Tenen; M S Vijayabaskar; David R Westhead; Mengchu Wu; Deborah Clarke; Berthold Göttgens; Rebecca Hannah; Richard Ingram; Valerie Kouskoff; Terence Allen; Salam A Assi; Constanze Bonifer
RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis.
The EMBO journal 2012;31(22):4318-33.
2012: Yue Zhang; Xinghui Zhao; Nicholas Zorko; Kelsie M Bernot; Michael A Caligiuri; Rajeana M Conway; Susumu Goyama; H Leighton Grimes; Guido Marcucci; James C Mulloy; Yalan Rao; Goro Sashida; Daniel G Tenen; Qian-Fei Wang; Susan P Whitman; David Witte; Zhijian Xiao; Xiaomei Yan; Gang Huang
Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells.
Blood 2012;120(5):1118-29.
2012: Hanna S Radomska; Meritxell Alberich-Jordà; Ruud Delwel; David Gonzalez; Britta Will; Daniel G Tenen
Targeting CDK1 promotes FLT3-activated acute myeloid leukemia differentiation through C/EBPα.
The Journal of clinical investigation 2012;122(8):2955-66.
2012: A Ptasinska; Daniel G Tenen; Reuben M Tooze; D R Westhead; D Williamson; M Wu; B D Young; S A Assi; M Care; P Cauchy; P N Cockerill; M Cullen; J Dunne; O Heidenreich; Maarten Hoogenkamp; S R James; D Mannari; H McNeill; C Bonifer
Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.
Leukemia 2012;26(8):1829-41.
2012: Daniela S Basseres; Francesco D'Alò; Tajhal Dayaram; John J Godleski; David A Gonzalez; Balazs Halmos; Susumu Kobayashi; Olivier Kocher; Ester C Löwenberg; Matthew Meyerson; William G Richards; Daniel G Tenen; Hiroyuki Yasuda; Beow Y Yeap; Daniel B Costa
Frequent downregulation of the transcription factor Foxa2 in lung cancer through epigenetic silencing.
Lung cancer (Amsterdam, Netherlands) 2012;77(1):31-7.
2012: Rositsa I Koleva; C John Luckey; Guido Marcucci; John A Alberta; Marlene J Carrasco-Alfonso; Scott B Ficarro; Hanna S Radomska; Daniel G Tenen; James T Webber; Jarrod A Marto
C/EBPα and DEK coordinately regulate myeloid differentiation.
Blood 2012;119(21):4878-88.
2011: Elena Levantini; Yutaka Okuno; Hanna S Radomska; Nicola K Wilson; Dong-Er Zhang; Junyan Zhang; Pu Zhang; Meritxell Alberich-Jorda; Giovanni Amabile; Daniela S Basseres; Constanze Bonifer; Alexander K Ebralidze; David A Gonzalez; Bertie Gottgens; Christopher J Hetherington; Gang Huang; Steffen Koschmieder; Sanghoon Lee; Daniel G Tenen
RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element.
The EMBO journal 2011;30(19):4059-70.
2011: John M Luk; Ulrike Philippar; Ronnie T Poon; Peter M Shaw; Felix H Shek; Daniel G Tenen; Kwong F Wong; Chunsheng Zhang; Julja Burchard; Carolyn A Buser; Michele A Cleary; Hongyue Dai; Sheung-Tat Fan; Irena Ivanovska; Chuen Neng Lee; Nikki P Y Lee; Angela M Liu; Mao Mao
DLK1-DIO3 genomic imprinted microRNA cluster at 14q32.2 defines a stemlike subtype of hepatocellular carcinoma associated with poor survival.
The Journal of biological chemistry 2011;286(35):30706-13.
2011: K B Grandinetti; S Ha; E C Peters; R J Salamone; T A Stevens; Daniel G Tenen; John R Walker; J Zhang; S Agarwalla; Venkateshwar A Reddy
Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPα.
Oncogene 2011;30(30):3328-35.
2011: Mathias Leddin; Chiara Perrod; Maarten Hoogenkamp; Saeed Ghani; Salam Assi; Sven Heinz; Nicola K Wilson; George Follows; Jörg Schönheit; Lena Vockentanz; Ali M Mosammam; Wei Chen; Daniel G Tenen; David R Westhead; Berthold Göttgens; Constanze Bonifer; Frank Rosenbauer
Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells.
Blood 2011;117(10):2827-38.
2011: Shuxian Jiang; Meritxell Alberich-Jorda; Radoslaw Zagozdzon; Kalindi Parmar; Yigong Fu; Peter Mauch; Naheed Banu; Alexandros Makriyannis; Daniel G Tenen; Shalom Avraham; Jerome E Groopman; Hava Karsenty Avraham
Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization.
Blood 2011;117(3):827-38.
2010: John A Pulikkan; Philomina S Peramangalam; Viola Dengler; Phoenix Anh-Dung Ho; Claude Preudhomme; Soheil Meshinchi; Maximilian Christopeit; Oliver Nibourel; Carsten Müller-Tidow; Stefan K Bohlander; Daniel G Tenen; Gerhard Behre
C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations.
Blood 2010;116(25):5638-49.
2010: Karen B O'Brien; Meritxell Alberich-Jordà; Neelu Yadav; Olivier Kocher; Annalisa Diruscio; Alexander Ebralidze; Elena Levantini; Natasha J L Sng; Manoj Bhasin; Tyler Caron; Daehoon Kim; Ulrich Steidl; Gang Huang; Balázs Halmos; Scott J Rodig; Mark T Bedford; Daniel G Tenen; Susumu Kobayashi
CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells.
Development (Cambridge, England) 2010;137(13):2147-56.
2010: Wee-Lee Yeo; Gregory J Riely; Beow Y Yeap; Michelle W Lau; Jeremy L Warner; Kelly Bodio; Mark S Huberman; Mark G Kris; Daniel G Tenen; William Pao; Susumu Kobayashi; Daniel B Costa
Erlotinib at a dose of 25 mg daily for non-small cell lung cancers with EGFR mutations.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010;5(7):1048-53.
2010: Yukiko Aikawa; Takuo Katsumoto; Pu Zhang; Haruko Shima; Mika Shino; Kiminori Terui; Etsuro Ito; Hiroaki Ohno; E Richard Stanley; Harinder Singh; Daniel G Tenen; Issay Kitabayashi
PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2.
Nature medicine 2010;16(5):580-5, 1p following 585.
2010: John A Pulikkan; V Dengler; A A Peer Zada; A Kawasaki; M Geletu; Z Pasalic; Stefan K Bohlander; A Ryo; Daniel G Tenen; G Behre
Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML.
Leukemia 2010;24(5):914-23.
2010: Britta Will; Tanya Siddiqi; Meritxell Alberich Jordà; Takeshi Shimamura; Katarina Luptakova; Philipp B Staber; Daniel B Costa; Ulrich Steidl; Daniel G Tenen; Susumu Kobayashi
Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells.
Blood 2010;115(14):2901-9.
2010: Naoka Kamio; Hideyo Hirai; Eishi Ashihara; Daniel G Tenen; Taira Maekawa; Jiro Imanishi
Use of bicistronic vectors in combination with flow cytometry to screen for effective small interfering RNA target sequences.
Biochemical and biophysical research communications 2010;393(3):498-503.
2010: John A Pulikkan; Viola Dengler; Philomina S Peramangalam; Abdul A Peer Zada; Carsten Müller-Tidow; Stefan K Bohlander; Daniel G Tenen; Gerhard Behre
Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia.
Blood 2010;115(9):1768-78.
2009: Florence C Guibal; Meritxell Alberich-Jorda; Hideyo Hirai; Alexander Ebralidze; Elena Levantini; Annalisa Di Ruscio; Pu Zhang; Barbara A Santana-Lemos; Donna Neuberg; Amy J Wagers; Eduardo M Rego; Daniel G Tenen
Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.
Blood 2009;114(27):5415-25.
2009: S Ueno; Hiro Tatetsu; Hiroyuki Hata; T Iino; H Niiro; K Akashi; Daniel G Tenen; Hiroaki Mitsuya; Yutaka Okuno
PU.1 induces apoptosis in myeloma cells through direct transactivation of TRAIL.
Oncogene 2009;28(46):4116-25.
2009: Maarten Hoogenkamp; Monika Lichtinger; Hanna Krysinska; Christophe Lancrin; Deborah Clarke; Andrew Williamson; Luca Mazzarella; Richard Ingram; Helle Jorgensen; Amanda Fisher; Daniel G Tenen; Valerie Kouskoff; Terence Allen; Constanze Bonifer
Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.
Blood 2009;114(2):299-309.
2009: Steffen Koschmieder; Balazs Halmos; Elena Levantini; Daniel G Tenen
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(4):619-28.
2008: Daniel B Costa; Kim-Son H Nguyen; Byoung C Cho; Lecia V Sequist; David M Jackman; Gregory J Riely; Beow Y Yeap; Balazs Halmos; Joo H Kim; Pasi A Janne; Mark S Huberman; William Pao; Daniel G Tenen; Susumu Kobayashi
Effects of erlotinib in EGFR mutated non-small cell lung cancers with resistance to gefitinib.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(21):7060-7.
2008: Alexander K Ebralidze; Florence C Guibal; Ulrich Steidl; Pu Zhang; Sanghoon Lee; Boris Bartholdy; Meritxell Alberich Jorda; Victoria Petkova; Frank Rosenbauer; Gang Huang; Tajhal Dayaram; Johanna Klupp; Karen B O'Brien; Britta Will; Maarten Hoogenkamp; Katherine L B Borden; Constanze Bonifer; Daniel G Tenen
PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.
Genes & development 2008;22(15):2085-92.
2008: Takeshi Shimamura; Danan Li; Hongbin Ji; Henry J Haringsma; Elizabeth Liniker; Christa L Borgman; April M Lowell; Yuko Minami; Kate McNamara; Samanthi A Perera; Sara Zaghlul; Roman K Thomas; Heidi Greulich; Susumu Kobayashi; Lucian R Chirieac; Robert F Padera; Shigeto Kubo; Masaya Takahashi; Daniel G Tenen; Matthew Meyerson; Kwok-Kin Wong; Geoffrey I Shapiro
Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance.
Cancer research 2008;68(14):5827-38.
2008: Guosheng Huang; Rosana Eisenberg; Min Yan; Stefano Monti; Earl Lawrence; Pingfu Fu; Jaclyn Walbroehl; Ester Löwenberg; Todd R Golub; Jaime Merchan; Daniel G Tenen; Sanford D Markowitz; Balazs Halmos
15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer.
Cancer research 2008;68(13):5040-8.
2008: Hyuk C Cha; Nikhil R Oak; Sona Kang; Tuan-Ahn Tran; Susumu Kobayashi; Shian-Huey Chiang; Daniel G Tenen; Ormond A MacDougald
Phosphorylation of CCAAT/enhancer-binding protein alpha regulates GLUT4 expression and glucose transport in adipocytes.
The Journal of biological chemistry 2008;283(26):18002-11.
2008: Peggy Kirstetter; Mikkel B Schuster; Oksana Bereshchenko; Susan Moore; Heidi Dvinge; Elke Kurz; Kim Theilgaard-Mönch; Robert Månsson; Thomas A Pedersen; Thomas Pabst; Evelin Schrock; Bo T Porse; Sten Eirik W Jacobsen; Paul Bertone; Daniel G Tenen; Claus Nerlov
Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.
Cancer cell 2008;13(4):299-310.
2008: Daniel B Costa; Susan T Schumer; Daniel G Tenen; Susumu Kobayashi
Differential responses to erlotinib in epidermal growth factor receptor (EGFR)-mutated lung cancers with acquired resistance to gefitinib carrying the L747S or T790M secondary mutations.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(7):1182-4; author reply 1184-6.
2008: Ingmar Bruns; Ulrich Steidl; Johannes C Fischer; Akos Czibere; Guido Kobbe; Sascha Raschke; Raminder Singh; Roland Fenk; Michael Rosskopf; Sabrina Pechtel; Arndt von Haeseler; Peter Wernet; Daniel G Tenen; Rainer Haas; Ralf Kronenwett
Pegylated granulocyte colony-stimulating factor mobilizes CD34+ cells with different stem and progenitor subsets and distinct functional properties in comparison with unconjugated granulocyte colony-stimulating factor.
Haematologica 2008;93(3):347-55.
2008: sake wageningen; Marleen C Breems-de Ridder; Jeannet Nigten; Gorica Nikoloski; Claudia A J Erpelinck-Verschueren; Bob Löwenberg; Theo de Witte; Daniel G Tenen; Bert A van der Reijden; Joop H Jansen
Gene transactivation without direct DNA binding defines a novel gain-of-function for PML-RARalpha.
Blood 2008;111(3):1634-43.
2008: Gang Huang; Pu Zhang; Hideyo Hirai; Shannon Elf; Xiaomei Yan; Zhao Chen; Steffen Koschmieder; Yutaka Okuno; Tajhal Dayaram; Joseph D Growney; Ramesh A Shivdasani; D Gary Gilliland; Nancy A Speck; Stephen D Nimer; Daniel G Tenen
PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.
Nature genetics 2008;40(1):51-60.
2007: Steffen Koschmieder; Francesco D'Alò; Hanna S Radomska; Christine Schöneich; Ji Suk Chang; Marina Konopleva; Susumu Kobayashi; Elena Levantini; Nanjoo Suh; Annalisa Di Ruscio; Maria Teresa Voso; Julie C Watt; Ramasamy Santhanam; Bülent Sargin; Andrew Lamb; Michael Andreeff; Michael B. Sporn; Danilo Perrotti; Wolfgang E Berdel; Carsten Müller-Tidow; Hubert Serve; Daniel G Tenen
CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha.
Blood 2007;110(10):3695-705.
2007: Bas J Wouters; Meritxell Alberich Jordà; Karen Keeshan; Irene Louwers; Claudia A J Erpelinck-Verschueren; Dennis Tielemans; Anton Langerak; Yiping He; Yumi Yashiro-ohtani; Pu Zhang; Christopher J Hetherington; Roel G W Verhaak; Peter J M Valk; Bob Löwenberg; Daniel G Tenen; Warren S Pear; Ruud Delwel
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.
Blood 2007;110(10):3706-14.
2007: Zhiwei Yu; Titus Boggon; Susumu Kobayashi; Cheng Jin; Patrick C Ma; Afshin Dowlati; Jeffrey A Kern; Daniel G Tenen; Balazs Halmos
Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies.
Cancer research 2007;67(21):10417-27.
2007: Maarten Hoogenkamp; Hanna Krysinska; Richard Ingram; Gang Huang; Rachael Barlow; Deborah Clarke; Alexander Ebralidze; Pu Zhang; Hiromi Tagoh; Peter N Cockerill; Daniel G Tenen; Constanze Bonifer
The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis.
Molecular and cellular biology 2007;27(21):7425-38.
2007: Mulu Geletu; Mumtaz Y Balkhi; Abdul A Peer Zada; Maximilian Christopeit; John A Pulikkan; Arun Trivedi; Daniel G Tenen; Gerhard Behre
Target proteins of C/EBPalphap30 in AML: C/EBPalphap30 enhances sumoylation of C/EBPalphap42 via up-regulation of Ubc9.
Blood 2007;110(9):3301-9.
2007: Christine Yeamans; Dehua Wang; Ido Paz-Priel; Bruce E Torbett; Daniel G Tenen; Alan D Friedman
C/EBPalpha binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment.
Blood 2007;110(9):3136-42.
2007: Daniel B Costa; Balazs Halmos; Amit Kumar; Susan T Schumer; Mark S Huberman; Titus Boggon; Daniel G Tenen; Susumu Kobayashi
BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations.
PLoS medicine 2007;4(10):1669-79; discussion 1680.
2007: Daniel B Costa; Susumu Kobayashi; Daniel G Tenen; Mark S Huberman
Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers.
Lung cancer (Amsterdam, Netherlands) 2007;58(1):95-103.
2007: Mark W Feinberg; Akm Khyrul Wara; Zhuoxiao Cao; Maria A Lebedeva; Frank Rosenbauer; Hiromi Iwasaki; Hideyo Hirai; Jonathan P Katz; Richard L Haspel; Susan Gray; Koichi Akashi; Julie Segre; Klaus kaestner; Daniel G Tenen; Mukesh K Jain
The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation.
The EMBO journal 2007;26(18):4138-48.
2007: Ulrich Steidl; Christian Steidl; Alexander Ebralidze; Bjoern Chapuy; Hye-Jung Han; Britta Will; Frank Rosenbauer; Annegret Becker; Katharina Wagner; Steffen Koschmieder; Susumu Kobayashi; Daniel B Costa; Thomas Schulz; Karen B O'Brien; Roel G W Verhaak; Ruud Delwel; Detlef Haase; Lorenz Trümper; Jürgen Krauter; Terumi Kohwi-Shigematsu; Frank Griesinger; Daniel G Tenen
A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.
The Journal of clinical investigation 2007;117(9):2611-20.
2007: Hiro Tatetsu; Shikiko Ueno; Hiroyuki Hata; Yasuhiro Yamada; Motohiro Takeya; Hiroaki Mitsuya; Daniel G Tenen; Yutaka Okuno
Down-regulation of PU.1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth.
Cancer research 2007;67(11):5328-36.
2007: Benoit Grondin; Martin Lefrancois; Mathieu Tremblay; Marianne Saint-Denis; André Haman; Kazuo Waga; André Bédard; Daniel G Tenen; Trang Hoang
c-Jun homodimers can function as a context-specific coactivator.
Molecular and cellular biology 2007;27(8):2919-33.
2007: Daniel B Costa; Sigui Li; Olivier Kocher; Richard Feins; Steven M Keller; Joan H Schiller; David H Johnson; Daniel G Tenen; Balazs Halmos
Immunohistochemical analysis of C/EBPalpha in non-small cell lung cancer reveals frequent down-regulation in stage II and IIIA tumors: a correlative study of E3590.
Lung cancer (Amsterdam, Netherlands) 2007;56(1):97-103.
2007: Frank Rosenbauer; Daniel G Tenen
Transcription factors in myeloid development: balancing differentiation with transformation.
Nature reviews. Immunology 2007;7(2):105-17.
2007: Ting Xi Liu; Jennifer Rhodes; Min Deng; Karl Hsu; Hanna S Radomska; John P Kanki; Daniel G Tenen; A Thomas Look
Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish.
Experimental hematology 2007;35(2):230-9.
2007: Steffen Koschmieder; Shuchi Agrawal; Hanna S Radomska; Claudia S Huettner; Daniel G Tenen; Oliver G Ottmann; Wolfgang E Berdel; Hubert Serve; Carsten Müller-Tidow
Decitabine and vitamin D3 differentially affect hematopoietic transcription factors to induce monocytic differentiation.
International journal of oncology 2007;30(2):349-55.
2006: Susumu Kobayashi; Takeshi Shimamura; Stefano Monti; Ulrich Steidl; Christopher J Hetherington; April M Lowell; Todd R Golub; Matthew Meyerson; Daniel G Tenen; Geoffrey I Shapiro; Balazs Halmos
Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling.
Cancer research 2006;66(23):11389-98.
2006: Abdul Ali Peer Zada; John A Pulikkan; D Bararia; Mulu Geletu; Arun Trivedi; Mumtaz Y Balkhi; Wolfgang Hiddemann; Daniel G Tenen; HM Behre; Gerhard Behre
Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link.
Leukemia 2006;20(12):2137-46.
2006: Hiromi Iwasaki; Shin-ichi Mizuno; Yojiro Arinobu; Hidetoshi Ozawa; Yasuo Mori; Hirokazu Shigematsu; Kiyoshi Takatsu; Daniel G Tenen; Koichi Akashi
The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages.
Genes & development 2006;20(21):3010-21.
2006: Ulrich Steidl; Frank Rosenbauer; Roel G W Verhaak; Xuesong Gu; Alexander Ebralidze; Hasan H Otu; Steffen Klippel; Christian Steidl; Ingmar Bruns; Daniel B Costa; Katharina Wagner; Manuel Aivado; Guido Kobbe; Peter J M Valk; Emmanuelle Passegué; Towia Libermann; Ruud Delwel; Daniel G Tenen
Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells.
Nature genetics 2006;38(11):1269-77.
2006: Abdul Ali Peer Zada; Mulu H Geletu; John A Pulikkan; Carsten Müller-Tidow; Venkateshwar A Reddy; Maximilian Christopeit; Wolfgang D Hiddemann; Hermann M Behre; Daniel G Tenen; Gerhard Behre
Proteomic analysis of acute promyelocytic leukemia: PML-RARalpha leads to decreased phosphorylation of OP18 at serine 63.
Proteomics 2006;6(21):5705-19.
2006: Marina Scheller; Joerg Huelsken; Frank Rosenbauer; Makoto M Taketo; Walter Birchmeier; Daniel G Tenen; Achim Leutz
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation.
Nature immunology 2006;7(10):1037-47.
2006: Young-Jin Lee; Letetia C Jones; Nikolai A Timchenko; Danilo Perrotti; Daniel G Tenen; Scott C Kogan
CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities.
Blood 2006;108(7):2416-9.
2006: Shigeto Kubo; Elena Levantini; Susumu Kobayashi; Olivier Kocher; Balazs Halmos; Daniel G Tenen; Masaya Takahashi
Three-dimensional magnetic resonance microscopy of pulmonary solitary tumors in transgenic mice.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2006;56(3):698-703.
2006: Daniel B Costa; Tajhal Dayaram; Francesco D'Alo; Bas J Wouters; Daniel G Tenen; Matthew Meyerson; Ming Tsao; Balazs Halmos
C/EBP alpha mutations in lung cancer.
Lung cancer (Amsterdam, Netherlands) 2006;53(2):253-4.
2006: Hideyo Hirai; Pu Zhang; Tajhal Dayaram; Christopher J Hetherington; Shin-ichi Mizuno; Jiro Imanishi; Koichi Akashi; Daniel G Tenen
C/EBPbeta is required for 'emergency' granulopoiesis.
Nature immunology 2006;7(7):732-9.
2006: Beatrice U Mueller; Thomas Pabst; P Hauser; G Gilliland; D Neuberg; Daniel G Tenen
Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia.
British journal of cancer 2006;94(12):1918-20.
2006: Thomas Pabst; Erica Stillner; Donna Neuberg; Stephen D Nimer; Cheryl L Willman; Alan F List; Junia V Melo; Daniel G Tenen; Beatrice U Mueller
Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia.
British journal of haematology 2006;133(4):400-2.
2006: Katharina Wagner; Pu Zhang; Frank Rosenbauer; Bettina Drescher; Susumu Kobayashi; Hanna S Radomska; Jeffery L Kutok; D Gary Gilliland; Jürgen Krauter; Daniel G Tenen
Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6338-43.
2006: Beatrice U Mueller; Thomas Pabst; José Fos; Vibor Petkovic; Martin F Fey; Norio Asou; Ulrich Buergi; Daniel G Tenen
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.
Blood 2006;107(8):3330-8.
2006: Hanna S Radomska; Daniela S Bassères; Rui Zheng; Pu Zhang; Tajhal Dayaram; Yukiya Yamamoto; David W Sternberg; Nathalie A Lokker; Neill A Giese; Stefan K Bohlander; Susanne Schnittger; Marie-Hélène Delmotte; Roger J Davis; Donald Small; Wolfgang Hiddemann; D Gary Gilliland; Daniel G Tenen
Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations.
The Journal of experimental medicine 2006;203(2):371-81.
2006: Daniela S Bassères; Elena Levantini; Hongbin Ji; Stefano Monti; Shannon Elf; Tajhal Dayaram; Maris L Fenyus; Olivier Kocher; Todd R Golub; Kwok-Kin Wong; Balazs Halmos; Daniel G Tenen
Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice.
Molecular and cellular biology 2006;26(3):1109-23.
2006: Hong Yin; Hanna S Radomska; Daniel G Tenen; Jonathan Glass
Down regulation of PSA by C/EBPalpha is associated with loss of AR expression and inhibition of PSA promoter activity in the LNCaP cell line.
BMC cancer 2006;6():158.
2006: Frank Rosenbauer; Bronwyn M. Owens; Li Yu; Joseph R Tumang; Ulrich Steidl; Jeffery L Kutok; Linda K Clayton; Katharina Wagner; Marina Scheller; Hiromi Iwasaki; Chunhui Liu; Björn Hackanson; Koichi Akashi; Achim Leutz; Thomas L Rothstein; Christoph Plass; Daniel G Tenen
Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.
Nature genetics 2006;38(1):27-37.
2005: Yojiro Arinobu; Hiromi Iwasaki; Michael F Gurish; Shin-ichi Mizuno; Hirokazu Shigematsu; Hidetoshi Ozawa; Daniel G Tenen; K Frank Austen; Koichi Akashi
Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(50):18105-10.
2005: Luke Peterson; Anita Boyapati; Velvizhi Ranganathan; Atsushi Iwama; Daniel G Tenen; Schickwann Tsai; Dong-Er Zhang
The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3.
Molecular and cellular biology 2005;25(23):10205-19.
2005: Jianqi Yang; Colleen Croniger; Julie Lekstrom-Himes; Pu Zhang; Maris L Fenyus; Daniel G Tenen; Gretchen Darlington; Richard W Hanson
Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alpha.
The Journal of biological chemistry 2005;280(46):38689-99.
2005: Erin Drew; Claudia S Huettner; Daniel G Tenen; Kelly M McNagny
CD34 expression by mast cells: of mice and men.
Blood 2005;106(5):1885-7.
2005: Frank Rosenbauer; Steffen Koschmieder; Ulrich Steidl; Daniel G Tenen
Effect of transcription-factor concentrations on leukemic stem cells.
Blood 2005;106(5):1519-24.
2005: Hiromi Iwasaki; Chamorro Somoza; Hirokazu Shigematsu; Estelle A Duprez; Junko Iwasaki-Arai; Shin-Ichi Mizuno; Yojiro Arinobu; Kristin Geary; Pu Zhang; Tajhal Dayaram; Maris L Fenyus; Shannon Elf; Susan Chan; Philippe Kastner; Claudia S Huettner; Richard Murray; Daniel G Tenen; Koichi Akashi
Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.
Blood 2005;106(5):1590-600.
2005: Toru Mukohara; Jeffrey A Engelman; Nasser H Hanna; Beow Y Yeap; Susumu Kobayashi; Neal Lindeman; Balazs Halmos; Joseph Pearlberg; Zenta Tsuchihashi; Lewis C Cantley; Daniel G Tenen; Bruce E Johnson; Pasi A Janne
Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations.
Journal of the National Cancer Institute 2005;97(16):1185-94.
2005: Susumu Kobayashi; Hongbin Ji; Yuki Yuza; Matthew Meyerson; Kwok-Kin Wong; Daniel G Tenen; Balazs Halmos
An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.
Cancer research 2005;65(16):7096-101.
2005: Steffen Koschmieder; Frank Rosenbauer; Ulrich Steidl; Bronwyn M. Owens; Daniel G Tenen
Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.
International journal of hematology 2005;81(5):368-77.
2005: Yutaka Okuno; Gang Huang; Frank Rosenbauer; Erica K. Evans; Hanna S Radomska; Hiromi Iwasaki; Koichi Akashi; Françoise Moreau-Gachelin; Youlin Li; Pu Zhang; Berthold Göttgens; Daniel G Tenen
Potential autoregulation of transcription factor PU.1 by an upstream regulatory element.
Molecular and cellular biology 2005;25(7):2832-45.
2005: Susumu Kobayashi; Titus Boggon; Tajhal Dayaram; Pasi A Janne; Olivier Kocher; Matthew Meyerson; Bruce E Johnson; Michael J Eck; Daniel G Tenen; Balazs Halmos
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib.
The New England journal of medicine 2005;352(8):786-92.
2005: Daniel Cho; Olivier Kocher; Jeffrey C Lee; Daniel G Tenen; Matthew Meyerson; Pasi A Janne; Balazs Halmos
Unusual cases in multiple myeloma and a dramatic response in metastatic lung cancer: case 4. Mutation of the epidermal growth factor receptor in an elderly man with advanced, gefitinib-responsive, non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(1):235-7.
2005: Steffen Koschmieder; Berthold Göttgens; Pu Zhang; Junko Iwasaki-Arai; Koichi Akashi; Jeffery L Kutok; Tajhal Dayaram; Kristin Geary; Anthony R Green; Daniel G Tenen; Claudia S Huettner
Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis.
Blood 2005;105(1):324-34.
2004: Pu Zhang; Junko Iwasaki-Arai; Hiromi Iwasaki; Maris L Fenyus; Tajhal Dayaram; Bronwyn M. Owens; Hirokazu Shigematsu; Elena Levantini; Claudia S Huettner; Julie Lekstrom-Himes; Koichi Akashi; Daniel G Tenen
Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha.
Immunity 2004;21(6):853-63.
2004: Olivera M. Mitrasinovic; Christopher C Robinson; Daniel G Tenen; Yuen Ling Lee; Clara Poon; Greer M Murphy
Biolistic expression of the macrophage colony stimulating factor receptor in organotypic cultures induces an inflammatory response.
Journal of neuroscience research 2004;77(3):420-9.
2004: Ulrich Steidl; Simone Bork; Sebastian Schaub; Oliver Selbach; Janette Seres; Manuel Aivado; Thomas Schroeder; Ulrich-Peter Rohr; Roland Fenk; Slawomir Kliszewski; Christian Maercker; Peter Neubert; Stefan R Bornstein; Helmut L Haas; Guido Kobbe; Daniel G Tenen; Rainer Haas; Ralf Kronenwett
Primary human CD34+ hematopoietic stem and progenitor cells express functionally active receptors of neuromediators.
Blood 2004;104(1):81-8.
2004: Balazs Halmos; Daniela S Bassères; Stefano Monti; Francesco D'Aló; Tajhal Dayaram; Katalin Ferenczi; Bas J Wouters; Claudia S Huettner; Todd R Golub; Daniel G Tenen
A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3 beta as a novel tumor suppressor in lung cancer.
Cancer research 2004;64(12):4137-47.
2004: Frank Rosenbauer; Katharina Wagner; Jeffery L Kutok; Hiromi Iwasaki; Michelle M Le Beau; Yutaka Okuno; Koichi Akashi; Steven Fiering; Daniel G Tenen
Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.
Nature genetics 2004;36(6):624-30.
2004: Frank Rosenbauer; Katharina Wagner; Pu Zhang; Klaus-Peter Knobeloch; Atsushi Iwama; Daniel G Tenen
pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1.
Blood 2004;103(11):4294-301.
2004: Maike Schwieger; Jürgen Löhler; Meike Fischer; Uwe Herwig; Daniel G Tenen; Carol Stocking
A dominant-negative mutant of C/EBPalpha, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse.
Blood 2004;103(7):2744-52.
2004: Sarah E Ross; Hanna S Radomska; Bo Wu; Pu Zhang; Jonathon Winnay; Laszlo Bajnok; Wendy S Wright; Fred Schaufele; Daniel G Tenen; Ormond A MacDougald
Phosphorylation of C/EBPalpha inhibits granulopoiesis.
Molecular and cellular biology 2004;24(2):675-86.
2003: Estelle Duprez; Katharina Wagner; Heike Koch; Daniel G Tenen
C/EBPbeta: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells.
The EMBO journal 2003;22(21):5806-16.
2003: Francesco D'Alo'; Lisa M Johansen; Erik A Nelson; Hanna S Radomska; Erica K. Evans; Pu Zhang; Claus Nerlov; Daniel G Tenen
The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells.
Blood 2003;102(9):3163-71.
2003: Claudia S Huettner; Steffen Koschmieder; Hiromi Iwasaki; Junko Iwasaki-Arai; Hanna S Radomska; Koichi Akashi; Daniel G Tenen
Inducible expression of BCR/ABL using human CD34 regulatory elements results in a megakaryocytic myeloproliferative syndrome.
Blood 2003;102(9):3363-70.
2003: Annika Elsässer; Michael Franzen; Alexander Kohlmann; Martin Weisser; Susanne Schnittger; Claudia Schoch; Venkateshwar A Reddy; Sebastien A Burel; Dong-Er Zhang; Marius Ueffing; Daniel G Tenen; Wolfgang Hiddemann; Gerhard Behre
The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner.
Oncogene 2003;22(36):5646-57.
2003: Janki Rangatia; Rajani K Vangala; Sheo M Singh; Abdul A Peer Zada; Annika Elsässer; Alexander Kohlmann; Torsten Haferlach; Daniel G Tenen; Wolfgang Hiddemann; Gerhard Behre
Elevated c-Jun expression in acute myeloid leukemias inhibits C/EBPalpha DNA binding via leucine zipper domain interaction.
Oncogene 2003;22(30):4760-4.
2003: Katsumi Yotsumoto; Yasushi Okoshi; Kazuko Shibuya; Satoshi Yamazaki; Satoko Tahara-Hanaoka; Shin-Ichiro Honda; Mitsujiro Osawa; Asato Kuroiwa; Yoichi Matsuda; Daniel G Tenen; Atsushi Iwama; Hiromitsu Nakauchi; Akira Shibuya
Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation.
The Journal of experimental medicine 2003;198(2):223-33.
2003: Abdul Ali Peer Zada; Sheo M Singh; Venkateshwar A Reddy; Annika Elsässer; Alexander Meisel; Torsten Haferlach; Daniel G Tenen; Wolfgang Hiddemann; Gerhard Behre
Downregulation of c-Jun expression and cell cycle regulatory molecules in acute myeloid leukemia cells upon CD44 ligation.
Oncogene 2003;22(15):2296-308.
2003: Beatrice U Mueller; Thomas Pabst; Motomi Osato; Norio Asou; Lisa M Johansen; Mark D Minden; Gerhard Behre; Wolfgang Hiddemann; Yoshiaki Ito; Daniel G Tenen
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
Blood 2003;101(5):2074.
2003: Daniel G Tenen
Disruption of differentiation in human cancer: AML shows the way.
Nature reviews. Cancer 2003;3(2):89-101.
2003: Bao-Tran H Truong; Young-Jin Lee; Tracey A Lodie; Dorothy J Park; Danilo Perrotti; Naohide Watanabe; H Phillip Koeffler; Hideaki Nakajima; Daniel G Tenen; Scott C Kogan
CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia.
Blood 2003;101(3):1141-8.
2003: Sahar Barjesteh van Waalwijk van Doorn-Khosrovani; Claudia Erpelinck; Joost Meijer; Susanna van Oosterhoud; Wim L J van Putten; Peter J M Valk; H Berna Beverloo; Daniel G Tenen; Bob Löwenberg; Ruud Delwel
Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.
The hematology journal : the official journal of the European Haematology Association / EHA 2003;4(1):31-40.
2003: Rajani K Vangala; Marion S Heiss-Neumann; Janki Rangatia; Sheo M Singh; Claudia Schoch; Daniel G Tenen; Wolfgang Hiddemann; Gerhard Behre
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
Blood 2003;101(1):270-7.
2002: Yutaka Okuno; Claudia S Huettner; Hanna S Radomska; Victoria Petkova; Hiromi Iwasaki; Koichi Akashi; Daniel G Tenen
Distal elements are critical for human CD34 expression in vivo.
Blood 2002;100(13):4420-6.
2002: Hanna S Radomska; David A Gonzalez; Yutaka Okuno; Hiromi Iwasaki; Andras Nagy; Koichi Akashi; Daniel G Tenen; Claudia S Huettner
Transgenic targeting with regulatory elements of the human CD34 gene.
Blood 2002;100(13):4410-9.
2002: Janki Rangatia; Rajani K Vangala; Nicolai Treiber; Pu Zhang; Hanna S Radomska; Daniel G Tenen; Wolfgang Hiddemann; Gerhard Behre
Downregulation of c-Jun expression by transcription factor C/EBPalpha is critical for granulocytic lineage commitment.
Molecular and cellular biology 2002;22(24):8681-94.
2002: Alana L Welm; Nikolai A Timchenko; Yasuko Ono; Hiroyuki Sorimachi; Hannah S Radomska; Daniel G Tenen; Julie Lekstrom-Himes; Gretchen Darlington
C/EBPalpha is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells.
The Journal of biological chemistry 2002;277(37):33848-56.
2002: Gerhard Behre; Venkateshwar A Reddy; Daniel G Tenen; Wolfgang Hiddemann; Abdul Ali Peer Zada; Sheo M Singh
Proteomic analysis of transcription factor interactions in myeloid stem cell development and leukaemia.
Expert opinion on therapeutic targets 2002;6(4):491-5.
2002: Beatrice U Mueller; Thomas Pabst; Motomi Osato; Norio Asou; Lisa M Johansen; Mark D Minden; Gerhard Behre; Wolfgang Hiddemann; Yoshiaki Ito; Daniel G Tenen
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
Blood 2002;100(3):998-1007.
2002: Gerhard Behre; Sheo M Singh; Huaitian Liu; Laura T Bortolin; Maximilian Christopeit; Hanna S Radomska; Janki Rangatia; Wolfgang Hiddemann; Alan D Friedman; Daniel G Tenen
Ras signaling enhances the activity of C/EBP alpha to induce granulocytic differentiation by phosphorylation of serine 248.
The Journal of biological chemistry 2002;277(29):26293-9.
2002: Venkateshwar A Reddy; Atsushi Iwama; Guergana Iotzova; Mathias Schulz; Annika Elsasser; Rajani K Vangala; Daniel G Tenen; Wolfgang Hiddemann; Gerhard Behre
Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions.
Blood 2002;100(2):483-90.
2002: Pu Zhang; Erik Nelson; Hanna S Radomska; Junko Iwasaki-Arai; Koichi Akashi; Alan D Friedman; Daniel G Tenen
Induction of granulocytic differentiation by 2 pathways.
Blood 2002;99(12):4406-12.
2002: Yutaka Okuno; Hiromi Iwasaki; Claudia S Huettner; Hanna S Radomska; David A Gonzalez; Daniel G Tenen; Koichi Akashi
Differential regulation of the human and murine CD34 genes in hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6246-51.
2002: Atsushi Iwama; Mitsujiro Osawa; Ryutaro Hirasawa; Noriko Uchiyama; Shin Kaneko; Masafumi Onodera; Kazuko Shibuya; Akira Shibuya; Charles Vinson; Daniel G Tenen; Hiromitsu Nakauchi
Reciprocal roles for CCAAT/enhancer binding protein (C/EBP) and PU.1 transcription factors in Langerhans cell commitment.
The Journal of experimental medicine 2002;195(5):547-58.
2002: Balazs Halmos; Claudia S Huettner; Olivier Kocher; Katalin Ferenczi; Daniel D Karp; Daniel G Tenen
Down-regulation and antiproliferative role of C/EBPalpha in lung cancer.
Cancer research 2002;62(2):528-34.
2001: Yiqun Li; Yutaka Okuno; Pumin Zhang; Hanna S Radomska; H Chen; Hiromi Iwasaki; Koichi Akashi; M J Klemsz; Scott R McKercher; Richard A Maki; Daniel G Tenen
Regulation of the PU.1 gene by distal elements.
Blood 2001;98(10):2958-65.
2001: Sebastien A Burel; N Harakawa; Liming Zhou; Thomas Pabst; Daniel G Tenen; Dong-Er Zhang
Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation.
Molecular and cellular biology 2001;21(16):5577-90.
2001: L M Johansen; A Iwama; Tracey A Lodie; K Sasaki; D W Felsher; Todd R Golub; Daniel G Tenen
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
Molecular and cellular biology 2001;21(11):3789-806.
2001: Thomas Pabst; Beatrice U Mueller; N Harakawa; C Schoch; T Haferlach; Gerhard Behre; Wolfgang Hiddemann; Dong-Er Zhang; Daniel G Tenen
AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.
Nature medicine 2001;7(4):444-51.
2001: Thomas Pabst; Beatrice U Mueller; Pumin Zhang; Hanna S Radomska; Sailaja Narravula; S Schnittger; Gerhard Behre; Wolfgang Hiddemann; Daniel G Tenen
Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia.
Nature genetics 2001;27(3):263-70.
2000: Pumin Zhang; X Zhang; A Iwama; C Yu; K A Smith; Beatrice U Mueller; Sailaja Narravula; Bruce E Torbett; Stuart H Orkin; Daniel G Tenen
PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding.
Blood 2000;96(8):2641-8.
2000: K L Rhoades; Christopher J Hetherington; N Harakawa; DA Yergeau; Liming Zhou; LQ Liu; Marie-Térèse Little; Daniel G Tenen; Dong-Er Zhang
Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model.
Blood 2000;96(6):2108-15.
2000: Claudia S Huettner; Pumin Zhang; Richard A Van Etten; Daniel G Tenen
Reversibility of acute B-cell leukaemia induced by BCR-ABL1.
Nature genetics 2000;24(1):57-60.
1999: Hanna S Radomska; A B Satterthwaite; NI Taranenko; Sailaja Narravula; Diane S Krause; Daniel G Tenen
A nuclear factor Y (NFY) site positively regulates the human CD34 stem cell gene.
Blood 1999;94(11):3772-80.
1999: P Zhang; Gerhard Behre; J Pan; A Iwama; Nawarat Wara-aswapati; Hanna S Radomska; Philip E. auron; Daniel G Tenen; Z Sun
Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8705-10.
1999: A Iwama; J Pan; P Zhang; W Reith; B Mach; Daniel G Tenen; Z Sun
Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.
Molecular and cellular biology 1999;19(6):3940-50.
1999: Gerhard Behre; A J Whitmarsh; Matthew P Coghlan; T Hoang; Christopher L Carpenter; Dong-Er Zhang; R J Davis; Daniel G Tenen
c-Jun is a JNK-independent coactivator of the PU.1 transcription factor.
The Journal of biological chemistry 1999;274(8):4939-46.
1999: G Behre; L T Smith; Daniel G Tenen
Use of a promoterless Renilla luciferase vector as an internal control plasmid for transient co-transfection assays of Ras-mediated transcription activation.
BioTechniques 1999;26(1):24-6, 28.
1998: Hanna S Radomska; A B Satterthwaite; T C Burn; I A Oliff; Claudia S Huettner; Daniel G Tenen
Multiple control elements are required for expression of the human CD34 gene.
Gene 1998;222(2):305-18.
1998: P Zhang; A Iwama; M W Datta; G J Darlington; D C Link; Daniel G Tenen
Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis.
The Journal of experimental medicine 1998;188(6):1173-84.
1998: Hanna S Radomska; Claudia S Huettner; Pumin Zhang; T Cheng; D T Scadden; Daniel G Tenen
CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors.
Molecular and cellular biology 1998;18(7):4301-14.
1998: M S Petrovick; S W Hiebert; Alan D Friedman; Christopher J Hetherington; Daniel G Tenen; Dong-Er Zhang
Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1.
Molecular and cellular biology 1998;18(7):3915-25.
1998: A Iwama; P Zhang; G J Darlington; Scott R McKercher; Rich Maki; Daniel G Tenen
Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha.
Nucleic acids research 1998;26(12):3034-43.
1998: H M Chen; David A Gonzalez; Hanna S Radomska; M T Voso; Z Sun; P Zhang; Dong-Er Zhang; Daniel G Tenen
Two promoters direct expression of the murine Spi-B gene, an Ets family transcription factor.
Gene 1998;207(2):209-18.
1997: Daniel G Tenen; R Hromas; Jonathan D Licht; Dong-Er Zhang
Transcription factors, normal myeloid development, and leukemia.
Blood 1997;90(2):489-519.
1997: Ryuya Yamanaka; G D Kim; H S Radomska; Julie Lekstrom-Himes; L T Smith; P Antonson; Daniel G Tenen; Kleanthis G Xanthopoulos
CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):6462-7.
1997: DA Yergeau; Christopher J Hetherington; Qingru Wang; P Zhang; A H Sharpe; Michael Binder; M Marín-Padilla; Daniel G Tenen; Nancy A Speck; Dong-Er Zhang
Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.
Nature genetics 1997;15(3):303-6.
1997: Y Yamaguchia; Daniel G Tenen; T Suda
Functional characterization of the promoter for the gene encoding murine CD34.
Biochimica et biophysica acta 1997;1350(2):141-6.
1997: Dong-Er Zhang; P Zhang; N D Wang; Christopher J Hetherington; Gretchen Darlington; Daniel G Tenen
Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):569-74.
1996: K L Rhoades; Christopher J Hetherington; Janet D Rowley; Scott W Hiebert; Giuseppina Nucifora; Daniel G Tenen; Dong-Er Zhang
Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11895-900.
1996: L T Smith; Stefan Hohaus; D A Gonzalez; Suzan Dziennis; Daniel G Tenen
PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells.
Blood 1996;88(4):1234-47.
1996: H Chen; P Zhang; Hanna S Radomska; Christopher J Hetherington; Dong-Er Zhang; Daniel G Tenen
Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter.
The Journal of biological chemistry 1996;271(26):15743-52.
1996: Dong-Er Zhang; Christopher J Hetherington; S Meyers; K L Rhoades; C J Larson; H M Chen; Scott W Hiebert; Daniel G Tenen
CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter.
Molecular and cellular biology 1996;16(3):1231-40.
1996: C S Zent; C Mathieu; D F Claxton; Dong-Er Zhang; Daniel G Tenen; Janet D Rowley; Giuseppina Nucifora
The chimeric genes AML1/MDS1 and AML1/EAP inhibit AML1B activation at the CSF1R promoter, but only AML1/MDS1 has tumor-promoter properties.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):1044-8.
1996: C Zent; N Kim; Scott W Hiebert; Dong-Er Zhang; Daniel G Tenen; Janet D Rowley; Giuseppina Nucifora
Rearrangement of the AML1/CBFA2 gene in myeloid leukemia with the 3;21 translocation: expression of co-existing multiple chimeric genes with similar functions as transcriptional repressors, but with opposite tumorigenic properties.
Current topics in microbiology and immunology 1996;211():243-52.
1996: Z Sun; D A Yergeau; I C Wong; T Tuypens; J Tavernier; Cassandra C Paul; Michael A Baumann; Philip E. auron; Daniel G Tenen; Steven J Ackerman
Interleukin-5 receptor alpha subunit gene regulation in human eosinophil development: identification of a unique cis-element that acts lie an enhancer in regulating activity of the IL-5R alpha promoter.
Current topics in microbiology and immunology 1996;211():173-87.
1996: Dong-Er Zhang; Stefan Hohaus; Maria Teresa Voso; H M Chen; L T Smith; Christopher J Hetherington; Daniel G Tenen
Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: regulation of multiple myeloid CSF receptor promoters.
Current topics in microbiology and immunology 1996;211():137-47.
1995: M C Olson; Edward W Scott; Andrew A Hack; G H Su; Daniel G Tenen; Harinder Singh; M Celeste Simon
PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation.
Immunity 1995;3(6):703-14.
1995: L Sompayrac; S Jane; T C Burn; Daniel G Tenen; K J Danna
Overcoming limitations of the mRNA differential display technique.
Nucleic acids research 1995;23(22):4738-9.
1995: H Chen; D Ray-Gallet; P Zhang; Christopher J Hetherington; D A Gonzalez; Dong-Er Zhang; Françoise Moreau-Gachelin; Daniel G Tenen
PU.1 (Spi-1) autoregulates its expression in myeloid cells.
Oncogene 1995;11(8):1549-60.
1995: Stefan Hohaus; M S Petrovick; Maria Teresa Voso; Z Sun; Dong-Er Zhang; Daniel G Tenen
PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.
Molecular and cellular biology 1995;15(10):5830-45.
1995: H M Chen; P Zhang; Maria Teresa Voso; Stefan Hohaus; D A Gonzalez; C K Glass; Dong-Er Zhang; Daniel G Tenen
Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B.
Blood 1995;85(10):2918-28.
1995: Z Sun; D A Yergeau; T Tuypens; J Tavernier; Cassandra C Paul; Michael A Baumann; Daniel G Tenen; Steven J Ackerman
Identification and characterization of a functional promoter region in the human eosinophil IL-5 receptor alpha subunit gene.
The Journal of biological chemistry 1995;270(3):1462-71.
1995: Suzan Dziennis; R A Van Etten; H L Pahl; D L Morris; T L Rothstein; C M Blosch; R M Perlmutter; Daniel G Tenen
The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice.
Blood 1995;85(2):319-29.
1994: Dong-Er Zhang; K Fujioka; Christopher J Hetherington; Linda H. Shapiro; H M Chen; A T Look; Daniel G Tenen
Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1).
Molecular and cellular biology 1994;14(12):8085-95.
1994: T C Burn; M S Petrovick; Stefan Hohaus; Barrett J Rollins; Daniel G Tenen
Monocyte chemoattractant protein-1 gene is expressed in activated neutrophils and retinoic acid-induced human myeloid cell lines.
Blood 1994;84(8):2776-83.
1994: Dong-Er Zhang; Christopher J Hetherington; D A Gonzalez; H M Chen; Daniel G Tenen
Regulation of CD14 expression during monocytic differentiation induced with 1 alpha,25-dihydroxyvitamin D3.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(7):3276-84.
1994: Maria Teresa Voso; T C Burn; G Wulf; B Lim; G Leone; Daniel G Tenen
Inhibition of hematopoiesis by competitive binding of transcription factor PU.1.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):7932-6.
1994: Y Yamaguchi; Dong-Er Zhang; Z Sun; E A Albee; S Nagata; Daniel G Tenen; Steven J Ackerman
Functional characterization of the promoter for the gene encoding human eosinophil peroxidase.
The Journal of biological chemistry 1994;269(30):19410-9.
1994: Dong-Er Zhang; Christopher J Hetherington; S Tan; Suzan Dziennis; D A Gonzalez; H M Chen; Daniel G Tenen
Sp1 is a critical factor for the monocytic specific expression of human CD14.
The Journal of biological chemistry 1994;269(15):11425-34.
1994: Dong-Er Zhang; Christopher J Hetherington; H M Chen; Daniel G Tenen
The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor.
Molecular and cellular biology 1994;14(1):373-81.
1993: H I Gomolin; Y Yamaguchi; A V Paulpillai; L A Dvorak; Steven J Ackerman; Daniel G Tenen
Human eosinophil Charcot-Leyden crystal protein: cloning and characterization of a lysophospholipase gene promoter.
Blood 1993;82(6):1868-74.
1993: H M Chen; H L Pahl; R J Scheibe; Dong-Er Zhang; Daniel G Tenen
The Sp1 transcription factor binds the CD11b promoter specifically in myeloid cells in vivo and is essential for myeloid-specific promoter activity.
The Journal of biological chemistry 1993;268(11):8230-9.
1993: H L Pahl; R J Scheibe; Dong-Er Zhang; H M Chen; D L Galson; R A Maki; Daniel G Tenen
The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter.
The Journal of biological chemistry 1993;268(7):5014-20.
1993: J C Fleming; H L Pahl; D A Gonzalez; T F Smith; Daniel G Tenen
Structural analysis of the CD11b gene and phylogenetic analysis of the alpha-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(2):480-90.
1993: Steven J Ackerman; S E Corrette; H F Rosenberg; J C Bennett; D M Mastrianni; A Nicholson-Weller; Peter Weller; D T Chin; Daniel G Tenen
Molecular cloning and characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). Similarities to IgE binding proteins and the S-type animal lectin superfamily.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(2):456-68.
1992: T C Burn; A B Satterthwaite; Daniel G Tenen
The human CD34 hematopoietic stem cell antigen promoter and a 3' enhancer direct hematopoietic expression in tissue culture.
Blood 1992;80(12):3051-9.
1992: Z Zhou; Daniel G Tenen; A M Dvorak; Steven J Ackerman
The gene for human eosinophil Charcot-Leyden crystal protein directs expression of lysophospholipase activity and spontaneous crystallization in transiently transfected COS cells.
Journal of leukocyte biology 1992;52(6):588-95.
1992: A G Rosmarin; R Levy; Daniel G Tenen
Cloning and analysis of the CD18 promoter.
Blood 1992;79(10):2598-604.
1992: D M Mastrianni; R L Eddy; H F Rosenberg; S E Corrette; T B Shows; Daniel G Tenen; Steven J Ackerman
Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14.
Genomics 1992;13(1):240-2.
1992: A B Satterthwaite; T C Burn; M M Le Beau; Daniel G Tenen
Structure of the gene encoding CD34, a human hematopoietic stem cell antigen.
Genomics 1992;12(4):788-94.
1992: D M Mastrianni; N M Tung; Daniel G Tenen
Acute myelogenous leukemia: current treatment and future directions.
The American journal of medicine 1992;92(3):286-95.
1992: H L Pahl; A G Rosmarin; Daniel G Tenen
Characterization of the myeloid-specific CD11b promoter.
Blood 1992;79(4):865-70.
1992: D L Simmons; A B Satterthwaite; Daniel G Tenen; Brian Seed
Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(1):267-71.
1991: H L Pahl; T C Burn; Daniel G Tenen
Optimization of transient transfection into human myeloid cell lines using a luciferase reporter gene.
Experimental hematology 1991;19(10):1038-41.
1991: L E Toothaker; D A Gonzalez; N Tung; R S Lemons; M M Le Beau; M A Arnaout; Linda K Clayton; Daniel G Tenen
Cellular myosin heavy chain in human leukocytes: isolation of 5' cDNA clones, characterization of the protein, chromosomal localization, and upregulation during myeloid differentiation.
Blood 1991;78(7):1826-33.
1991: H F Rosenberg; S E Corrette; Daniel G Tenen; Steven J Ackerman
Rapid cDNA library screening using the polymerase chain reaction.
BioTechniques 1991;10(1):53-4.
1990: A B Satterthwaite; R Borson; Daniel G Tenen
Regulation of the gene for CD34, a human hematopoietic stem cell antigen, in KG-1 cells.
Blood 1990;75(12):2299-304.
1990: H F Rosenberg; Steven J Ackerman; Daniel G Tenen
An alternative method for labeling oligonucleotide probes for screening cDNA libraries.
BioTechniques 1990;8(4):384.
1990: Daniel G Tenen; A B Satterthwaite; R Borson; D Simmons; R L Eddy; T B Shows
Chromosome 1 localization of the gene for CD34, a surface antigen of human stem cells.
Cytogenetics and cell genetics 1990;53(1):55-7.
1989: H F Rosenberg; Steven J Ackerman; Daniel G Tenen
Human eosinophil cationic protein. Molecular cloning of a cytotoxin and helminthotoxin with ribonuclease activity.
The Journal of experimental medicine 1989;170(1):163-76.
1989: H F Rosenberg; Daniel G Tenen; Steven J Ackerman
Molecular cloning of the human eosinophil-derived neurotoxin: a member of the ribonuclease gene family.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4460-4.
1989: A G Rosmarin; S C Weil; G L Rosner; James D Griffin; M A Arnaout; Daniel G Tenen
Differential expression of CD11b/CD18 (Mo1) and myeloperoxidase genes during myeloid differentiation.
Blood 1989;73(1):131-6.
1989: D L Simmons; S Tan; Daniel G Tenen; A Nicholson-Weller; Brian Seed
Monocyte antigen CD14 is a phospholipid anchored membrane protein.
Blood 1989;73(1):284-9.