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John Tentler

Research Profile

Chemicals & Drugs

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Colorectal Neoplasms

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Todd M Pitts; Heather M Selby; Anna Spreafico; Aik Choon Tan; John J Tentler; Marileila Varella-Garcia; John Arcaroli; Erica L Bradshaw-Pierce; Blair C Britt; Maria I Kachaeva; Gillian N Kulikowski; Kelly L McPhillips; Wells A Messersmith; Brion W Murray; S Gail Eckhardt
Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models.
Jennifer R Diamond; S Gail Eckhardt; Graham C Fletcher; Maria I Kachaeva; Timothy P Newton; Todd M Pitts; Heather M Selby; Aik Choon Tan; Mark R Bray; Kelsey L Brunkow; Marileila Varella-Garcia; John J Tentler
Predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor ENMD-2076 in preclinical breast cancer models.
John J Tentler; Colin D Weekes; John Arcaroli; Antonio Jimeno; Stephen Leong; Wells A Messersmith; Todd M Pitts; Aik Choon Tan; S Gail Eckhardt
Patient-derived tumour xenografts as models for oncology drug development.

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All Publications

2013: Todd M Pitts; Heather M Selby; Anna Spreafico; Aik Choon Tan; John J Tentler; Marileila Varella-Garcia; John Arcaroli; Erica L Bradshaw-Pierce; Blair C Britt; Maria I Kachaeva; Gillian N Kulikowski; Kelly L McPhillips; Wells A Messersmith; Brion W Murray; S Gail Eckhardt
Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models.
Frontiers in pharmacology 2013;4():35.
2013: Jennifer R Diamond; S Gail Eckhardt; Graham C Fletcher; Maria I Kachaeva; Timothy P Newton; Todd M Pitts; Heather M Selby; Aik Choon Tan; Mark R Bray; Kelsey L Brunkow; Marileila Varella-Garcia; John J Tentler
Predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor ENMD-2076 in preclinical breast cancer models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(1):291-303.
2012: John J Tentler; Colin D Weekes; John Arcaroli; Antonio Jimeno; Stephen Leong; Wells A Messersmith; Todd M Pitts; Aik Choon Tan; S Gail Eckhardt
Patient-derived tumour xenografts as models for oncology drug development.
Nature reviews. Clinical oncology 2012;9(6):338-50.
2012: M Pia Morelli; Sujatha Nallapareddy; Todd M Pitts; Natalie J Serkova; Aik Choon Tan; John J Tentler; John J Arcaroli; Erica L Bradshaw-Pierce; Amy M Brown; Fortunato Ciardiello; Manuel Hidalgo; Gillian N Kulikowski; S Gail Eckhardt
Preclinical activity of the rational combination of selumetinib (AZD6244) in combination with vorinostat in KRAS-mutant colorectal cancer models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(4):1051-62.
2011: Jennifer Spratlin; T M Pitts; G N Kulikowski; M P Morelli; John J Tentler; N J Serkova; S Gail Eckhardt
Synergistic activity of histone deacetylase and proteasome inhibition against pancreatic and hepatocellular cancer cell lines.
Anticancer research 2011;31(4):1093-103.
2011: Jason D Prescott; John J Tentler; Darius M Walker; Joanna M Poczobutt; Arthur Gutierrez-Hartmann
Mapping of ESE-1 subdomains required to initiate mammary epithelial cell transformation via a cytoplasmic mechanism.
Molecular cancer 2011;10():103.
2010: John J Tentler; Sujatha Nallapareddy; Aik Choon Tan; Anna Spreafico; Todd M Pitts; M Pia Morelli; Heather M Selby; Maria I Kachaeva; Sara A Flanigan; Gillian N Kulikowski; Stephen Leong; John J Arcaroli; Wells A Messersmith; S Gail Eckhardt
Identification of predictive markers of response to the MEK1/2 inhibitor selumetinib (AZD6244) in K-ras-mutated colorectal cancer.
Molecular cancer therapeutics 2010;9(12):3351-62.
2010: Sara A Flanigan; Todd M Pitts; S Gail Eckhardt; John J Tentler; Aik Choon Tan; Andrew Thorburn; Stephen Leong
The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(22):5436-46.
2010: Todd M Pitts; Aik Choon Tan; Gillian N Kulikowski; John J Tentler; Amy M Brown; Sara A Flanigan; Stephen Leong; Christopher D Coldren; Fred R Hirsch; Marileila Varella-Garcia; Christopher Korch; S Gail Eckhardt
Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(12):3193-204.
2009: M Pia Morelli; Amy M Brown; Todd M Pitts; John J Tentler; Fortunato Ciardiello; Anderson Ryan; Juliane M Jürgensmeier; S Gail Eckhardt
Targeting vascular endothelial growth factor receptor-1 and -3 with cediranib (AZD2171): effects on migration and invasion of gastrointestinal cancer cell lines.
Molecular cancer therapeutics 2009;8(9):2546-58.
2009: Todd M Pitts; Mark Morrow; Sara A Kaufman; John J Tentler; S Gail Eckhardt
Vorinostat and bortezomib exert synergistic antiproliferative and proapoptotic effects in colon cancer cell models.
Molecular cancer therapeutics 2009;8(2):342-9.
2004: Kathryn N Farrow; Andrew P Bradford; John J Tentler; Arthur Gutierrez-Hartmann
Structural and functional analysis of the differential effects of c-Jun and v-Jun on prolactin gene expression.
Molecular endocrinology (Baltimore, Md.) 2004;18(10):2479-90.
2004: Pepper Schedin; Kristin L Eckel-Mahan; Shauntae M McDaniel; Jason D Prescott; Kelley S Brodsky; John J Tentler; Arthur Gutierrez-Hartmann
ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells.
Oncogene 2004;23(9):1766-79.
2003: Kristin L Eckel; John J Tentler; Gerald J Cappetta; Scott E Diamond; Arthur Gutierrez-Hartmann
The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression.
DNA and cell biology 2003;22(2):79-94.
2003: John J Tentler; Andrew P Bradford; Rebecca E Schweppe; Arthur Gutierrez-Hartmann
Selective repression of rat prolactin gene by stable expression of dominant-negative Ets in GH4 pituitary cells.
Endocrine 2003;20(1-2):3-12.
1997: John J Tentler; J R Hadcock; Arthur Gutierrez-Hartmann
Somatostatin acts by inhibiting the cyclic 3',5'-adenosine monophosphate (cAMP)/protein kinase A pathway, cAMP response element-binding protein (CREB) phosphorylation, and CREB transcription potency.
Molecular endocrinology (Baltimore, Md.) 1997;11(7):859-66.