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William Tepp

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Chan Lan Chun; Eric A Johnson; Guangyun Lin; Urs Ochsner; Julie Peller; William H Tepp; Richard L Whitman; Muruleedhara N Byappanahalli; Michael J Sadowsky
Association of toxin-producing Clostridium botulinum with the macroalga Cladophora in the Great Lakes.
Lisheng Peng; Hongyu Ruan; William H Stoothoff; William H Tepp; Wei-Dong Yao; Su-Chun Zhang; Robert H Brown; Eric A Johnson; Huisheng Liu; Min Dong
Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival.
Regina C M Whitemarsh; Sabine Pellett; Christina L Pier; William H Tepp; Eric A Johnson
Model for studying Clostridium botulinum neurotoxin using differentiated motor neuron-like NG108-15 cells.

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2013: Chan Lan Chun; Eric A Johnson; Guangyun Lin; Urs Ochsner; Julie Peller; William H Tepp; Richard L Whitman; Muruleedhara N Byappanahalli; Michael J Sadowsky
Association of toxin-producing Clostridium botulinum with the macroalga Cladophora in the Great Lakes.
Environmental science & technology 2013;47(6):2587-94.
2013: Lisheng Peng; Hongyu Ruan; William H Stoothoff; William H Tepp; Wei-Dong Yao; Su-Chun Zhang; Robert H Brown; Eric A Johnson; Huisheng Liu; Min Dong
Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival.
Nature communications 2013;4():1472.
2012: Regina C M Whitemarsh; Sabine Pellett; Christina L Pier; William H Tepp; Eric A Johnson
Model for studying Clostridium botulinum neurotoxin using differentiated motor neuron-like NG108-15 cells.
Biochemical and biophysical research communications 2012;427(2):426-30.
2012: Shihu Sun; William H Tepp; Eric A Johnson; Edwin R Chapman
Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pH.
Biochemistry 2012;51(28):5655-62.
2012: Lisheng Peng; Rose M Pitkin; Pål Stenmark; William H Tepp; Ronnie P-A Berntsson; Eric A Johnson; Min Dong
Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins.
Journal of cell science 2012;125(Pt 13):3233-42.
2012: William H Tepp; Guangyun Lin; Eric A Johnson
Purification and characterization of a novel subtype a3 botulinum neurotoxin.
Applied and environmental microbiology 2012;78(9):3108-13.
2012: Regina C M Whitemarsh; Lucas G Chase; Eric A Johnson; Casey Stankewicz; Monica J Strathman; William H Tepp; Sabine Pellett
Novel application of human neurons derived from induced pluripotent stem cells for highly sensitive botulinum neurotoxin detection.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(2):426-35.
2011: Felix L Yeh; Yiming Zhu; Paul J Bertics; Eric A Johnson; William H Tepp; Edwin R Chapman
Retargeted clostridial neurotoxins as novel agents for treating chronic diseases.
Biochemistry 2011;50(48):10419-21.
2011: James S Henkel; Eric A Johnson; Amanda Przedpelski; William H Tepp; Robert B Fritz; Joseph T Barbieri
Subunit vaccine efficacy against Botulinum neurotoxin subtypes.
Vaccine 2011;29(44):7688-95.
2011: Shihu Sun; Swetha Suresh; William H Tepp; J Michael Edwardson; Eric A Johnson; Huisheng Liu; Edwin R Chapman
Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly.
Cell host & microbe 2011;10(3):237-47.
2011: David M White; Mark A Jensen; Eric A Johnson; Sabine Pellett; William H Tepp; Barry G W Arnason
Rapid immune responses to a botulinum neurotoxin Hc subunit vaccine through in vivo targeting to antigen-presenting cells.
Infection and immunity 2011;79(8):3388-96.
2011: Mark J Jacobson; Jerome Dupuy; Guangyun Lin; Pål Stenmark; Raymond C Stevens; William H Tepp; Eric A Johnson
Purification, modeling, and analysis of botulinum neurotoxin subtype A5 (BoNT/A5) from Clostridium botulinum strain A661222.
Applied and environmental microbiology 2011;77(12):4217-22.
2011: Lisheng Peng; William H Tepp; Eric A Johnson; Min Dong
Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors.
PLoS pathogens 2011;7(3):e1002008.
2011: Sabine Pellett; William H Tepp; Larry H Stanker; Philip A Band; Eric A Johnson; Konstantin Ichtchenko
Neuronal targeting, internalization, and biological activity of a recombinant atoxic derivative of botulinum neurotoxin A.
Biochemical and biophysical research communications 2011;405(4):673-7.
2011: Sabine Pellett; Zhong-wei Du; Christina L Pier; William H Tepp; Su-chun Zhang; Eric A Johnson
Sensitive and quantitative detection of botulinum neurotoxin in neurons derived from mouse embryonic stem cells.
Biochemical and biophysical research communications 2011;404(1):388-92.
2011: Christina L Pier; Chen Chen; William H Tepp; Guangyun Lin; Kim D Janda; Joseph T Barbieri; Sabine Pellett; Eric A Johnson
Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1.
FEBS letters 2011;585(1):199-206.
2010: Sabine Pellett; William H Tepp; Stephen I Toth; Eric A Johnson
Comparison of the primary rat spinal cord cell (RSC) assay and the mouse bioassay for botulinum neurotoxin type A potency determination.
Journal of pharmacological and toxicological methods 2010;61(3):304-10.
2010: Yuya Nakai; Sabine Pellett; William H Tepp; Eric A Johnson; Kim D Janda
Toosendanin: synthesis of the AB-ring and investigations of its anti-botulinum properties (Part II).
Bioorganic & medicinal chemistry 2010;18(3):1280-7.
2010: Felix L Yeh; Min Dong; Jun Yao; William H Tepp; Guangyun Lin; Eric A Johnson; Edwin R Chapman
SV2 mediates entry of tetanus neurotoxin into central neurons.
PLoS pathogens 2010;6(11):e1001207.
2010: Marite Bradshaw; Kristin M Marshall; John T Heap; William H Tepp; Nigel P Minton; Eric A Johnson
Construction of a nontoxigenic Clostridium botulinum strain for food challenge studies.
Applied and environmental microbiology 2010;76(2):387-93.
2010: Guangyun Lin; William H Tepp; Christina L Pier; Mark J Jacobson; Eric A Johnson
Expression of the Clostridium botulinum A2 neurotoxin gene cluster proteins and characterization of the A2 complex.
Applied and environmental microbiology 2010;76(1):40-7.
2009: D L Trott; M Yang; J Gonzalez; A E Larson; William H Tepp; Eric A Johnson; M E Cook
Egg yolk antibodies for detection and neutralization of Clostridium botulinum type A neurotoxin.
Journal of food protection 2009;72(5):1005-11.
2009: Megan L Frisk; William H Tepp; Eric A Johnson; David J Beebe
Self-assembled peptide monolayers as a toxin sensing mechanism within arrayed microchannels.
Analytical chemistry 2009;81(7):2760-7.
2009: James S Henkel; Mark Jacobson; William H Tepp; Christina Pier; Eric A Johnson; Joseph T Barbieri
Catalytic properties of botulinum neurotoxin subtypes A3 and A4.
Biochemistry 2009;48(11):2522-8.
2009: Audrey Fischer; Yuya Nakai; Lisa M Eubanks; Colin M Clancy; William H Tepp; Sabine Pellett; Tobin J Dickerson; Eric A Johnson; Kim D Janda; Mauricio Montal
Bimodal modulation of the botulinum neurotoxin protein-conducting channel.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(5):1330-5.
2009: Yuya Nakai; William H Tepp; Tobin J Dickerson; Eric A Johnson; Kim D Janda
Function-oriented synthesis applied to the anti-botulinum natural product toosendanin.
Bioorganic & medicinal chemistry 2009;17(3):1152-7.
2008: Arun Iyer; Alexandra L Blinkova; Shing-Yi Yang; Mary Harrison; William H Tepp; Mark J Jacobson; Eric A Johnson; George N Bennett; James R Walker
Clostridium taeniosporum is a close relative of the Clostridium botulinum Group II.
Anaerobe 2008;14(6):318-24.
2008: Min Dong; Huisheng Liu; William H Tepp; Eric A Johnson; Roger Janz; Edwin R Chapman
Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.
Molecular biology of the cell 2008;19(12):5226-37.
2008: Megan L Frisk; Erwin Berthier; William H Tepp; Eric A Johnson; David J Beebe
Bead-based microfluidic toxin sensor integrating evaporative signal amplification.
Lab on a chip 2008;8(11):1793-800.
2008: Luisa W Cheng; Bruce Onisko; Eric A Johnson; J Rachel Reader; Stephen M Griffey; Ann E Larson; William H Tepp; Larry H Stanker; David L Brandon; John Mark Carter
Effects of purification on the bioavailability of botulinum neurotoxin type A.
Toxicology 2008;249(2-3):123-9.
2008: Bin Zhou; Sabine Pellett; William H Tepp; Heyue Zhou; Eric A Johnson; Kim D Janda
Delineating the susceptibility of botulinum neurotoxins to denaturation through thermal effects.
FEBS letters 2008;582(10):1526-31.
2008: Michael R Baldwin; William H Tepp; Amanda Przedpelski; Christina L Pier; Marite Bradshaw; Eric A Johnson; Joseph T Barbieri
Subunit vaccine against the seven serotypes of botulism.
Infection and immunity 2008;76(3):1314-8.
2008: Christina L Pier; William H Tepp; Marite Bradshaw; Eric A Johnson; Joseph T Barbieri; Michael R Baldwin
Recombinant holotoxoid vaccine against botulism.
Infection and immunity 2008;76(1):437-42.
2007: Min Dong; William H Tepp; Huisheng Liu; Eric A Johnson; Edwin R Chapman
Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons.
The Journal of cell biology 2007;179(7):1511-22.
2007: Sabine Pellett; William H Tepp; Colin M Clancy; Gary E Borodic; Eric A Johnson
A neuronal cell-based botulinum neurotoxin assay for highly sensitive and specific detection of neutralizing serum antibodies.
FEBS letters 2007;581(25):4803-8.
2007: Lisa M Eubanks; Mark Hixon; Wei Jin; Sukwon Hong; Colin M Clancy; William H Tepp; Michael R Baldwin; Carl J Malizio; Michael C Goodnough; Joseph T Barbieri; Eric A Johnson; Dale L Boger; Tobin J Dickerson; Kim D Janda
An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2602-7.
2006: Qing Chai; Joseph W Arndt; Min Dong; William H Tepp; Eric A Johnson; Edwin R Chapman; Raymond C Stevens
Structural basis of cell surface receptor recognition by botulinum neurotoxin B.
Nature 2006;444(7122):1096-100.
2006: Joseph W Arndt; Mark J Jacobson; Enrique E Abola; Charles M Forsyth; William H Tepp; James D Marks; Eric A Johnson; Raymond C Stevens
A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4.
Journal of molecular biology 2006;362(4):733-42.
2006: Min Dong; Felix Yeh; William H Tepp; Camin Dean; Eric A Johnson; Roger Janz; Edwin R Chapman
SV2 is the protein receptor for botulinum neurotoxin A.
Science (New York, N.Y.) 2006;312(5773):592-6.
2005: Michael R Baldwin; William H Tepp; Christina L Pier; Marite Bradshaw; Mengfei Ho; Brenda A Wilson; Robert B Fritz; Eric A Johnson; Joseph T Barbieri
Characterization of the antibody response to the receptor binding domain of botulinum neurotoxin serotypes A and E.
Infection and immunity 2005;73(10):6998-7005.
2005: T J Smith; Jianlong Lou; Isin Geren; Charles M Forsyth; R Tsai; Sherry L. LaPorte; William H Tepp; Marite Bradshaw; Eric A Johnson; LA Smith; James D Marks
Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization.
Infection and immunity 2005;73(9):5450-7.
2005: Bibhuti R Dasgupta; Babu S Antharavally; William H Tepp; Mary L Evenson
Botulinum neurotoxin types A, B, and E: fragmentations by autoproteolysis and other mechanisms including by O-phenanthroline-dithiothreitol, and association of the dinucleotides NAD(+)/NADH with the heavy chain of the three neurotoxins.
The protein journal 2005;24(6):337-68.
2005: Eric A Johnson; William H Tepp; Marite Bradshaw; Richard J Gilbert; Paul E Cook; E D G McIntosh
Characterization of Clostridium botulinum strains associated with an infant botulism case in the United Kingdom.
Journal of clinical microbiology 2005;43(6):2602-7.
2004: Min Dong; William H Tepp; Eric A Johnson; Edwin R Chapman
Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(41):14701-6.
2004: Jaisree Moorthy; Glennys A Mensing; Dongshin Kim; Swomitra Mohanty; David Thomas Eddington; William H Tepp; Eric A Johnson; David J Beebe
Microfluidic tectonics platform: A colorimetric, disposable botulinum toxin enzyme-linked immunosorbent assay system.
Electrophoresis 2004;25(10-11):1705-13.
2004: Chanokporn Sukonpan; Thorsten Oost; M Goodnough; William H Tepp; Eric A Johnson; Daniel H Rich
Synthesis of substrates and inhibitors of botulinum neurotoxin type A metalloprotease.
The journal of peptide research : official journal of the American Peptide Society 2004;63(2):181-93.
2003: Min Dong; David A Richards; Michael C Goodnough; William H Tepp; Eric A Johnson; Edwin R Chapman
Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells.
The Journal of cell biology 2003;162(7):1293-303.
2003: Thorsten Oost; Chanokporn Sukonpan; Matthias Brewer; Michael Goodnough; William H Tepp; Eric A Johnson; Daniel H Rich
Design and synthesis of substrate-based inhibitors of botulinum neurotoxin type B metalloprotease.
Biopolymers 2003;71(6):602-19.
2002: Michael C Goodnough; George A Oyler; Paul S Fishman; Eric A Johnson; Elaine A Neale; James E Keller; William H Tepp; Mike Clark; Stephanie Hartz; Michael Adler
Development of a delivery vehicle for intracellular transport of botulinum neurotoxin antagonists.
FEBS letters 2002;513(2-3):163-8.
2001: S Prabakaran; William H Tepp; Bibhuti R Dasgupta
Botulinum neurotoxin types B and E: purification, limited proteolysis by endoproteinase Glu-C and pepsin, and comparison of their identified cleaved sites relative to the three-dimensional structure of type A neurotoxin.
Toxicon : official journal of the International Society on Toxinology 2001;39(10):1515-31.
1998: D B Lacy; William H Tepp; A C Cohen; Bibhuti R Dasgupta; Raymond C Stevens
Crystal structure of botulinum neurotoxin type A and implications for toxicity.
Nature structural biology 1998;5(10):898-902.
1998: Babu S Antharavally; William H Tepp; Bibhuti R Dasgupta
Status of Cys residues in the covalent structure of botulinum neurotoxin types A, B, and E.
Journal of protein chemistry 1998;17(3):187-96.
1993: Bibhuti R Dasgupta; William H Tepp
Protease activity of botulinum neurotoxin type E and its light chain: cleavage of actin.
Biochemical and biophysical research communications 1993;190(2):470-4.
1991: R C Stevens; M L Evenson; William H Tepp; Bibhuti R Dasgupta
Crystallization and preliminary X-ray analysis of botulinum neurotoxin type A.
Journal of molecular biology 1991;222(4):877-80.