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Fumiko Terasawa

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Tamaki Kobayashi; Yuka Takezawa; Fumiko Terasawa; Nobuo Okumura
[Comparison of fibrinogen synthesis and secretion between novel variant fibrinogen, nagakute (gamma305Thr --> Ala), and other variants located in gamma305-308 residues].
Keisuke Soya; Yuka Takezawa; Fumiko Terasawa; Nobuo Okumura
[Functional analysis for dysfibrinogenemias, Toyama and Adachi, which have a mutation of Aalpha16Arg-->His (CGT-->CAT) with aberrant fibrinopeptide A release].
Fumiko Terasawa; Yuka Takezawa; Masako Hirota-Kawadobora; Nobuo Okumura
[Role of fibrinogen Bbeta-chain D-region 454-458 residues for assembly and secretion of intact fibrinogen].

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2012: Tamaki Kobayashi; Yuka Takezawa; Fumiko Terasawa; Nobuo Okumura
[Comparison of fibrinogen synthesis and secretion between novel variant fibrinogen, nagakute (gamma305Thr --> Ala), and other variants located in gamma305-308 residues].
Rinsho byori. The Japanese journal of clinical pathology 2012;60(9):831-8.
2012: Keisuke Soya; Yuka Takezawa; Fumiko Terasawa; Nobuo Okumura
[Functional analysis for dysfibrinogenemias, Toyama and Adachi, which have a mutation of Aalpha16Arg-->His (CGT-->CAT) with aberrant fibrinopeptide A release].
Rinsho byori. The Japanese journal of clinical pathology 2012;60(6):499-505.
2011: Fumiko Terasawa; Yuka Takezawa; Masako Hirota-Kawadobora; Nobuo Okumura
[Role of fibrinogen Bbeta-chain D-region 454-458 residues for assembly and secretion of intact fibrinogen].
Rinsho byori. The Japanese journal of clinical pathology 2011;59(8):741-8.
2010: Fumiko Terasawa; Yuka Kamijyo; Noriko Fujihara; Kazuyoshi Yamauchi; Toshiko Kumagai; Takayuki Honda; Satoshi Shigematsu; Nobuo Okumura
In vitro transcription of compound heterozygous hypofibrinogenemia Matsumoto IX; first identification of FGB IVS6 deletion of 4 nucleotides and FGG IVS3-2A>G causing abnormal RNA splicing.
Clinica chimica acta; international journal of clinical chemistry 2010;411(17-18):1325-9.
2010: Fumiko Terasawa; Yuka Kamijyo; Noriko Fujihara; Nobuo Okumura
[Assembly and secretion of mutant fibrinogens with variant gamma-chain C terminal region (gamma313-gamma345)].
Rinsho byori. The Japanese journal of clinical pathology 2010;58(8):772-8.
2009: Yuka Kamijyo; Masako Hirota-Kawadobora; Kazuyoshi Yamauchi; Fumiko Terasawa; Takayuki Honda; Manae Ikeya; Nobuo Okumura
Analysis of plasmin generation and clot lysis of plasma fibrinogen purified from a heterozygous dysfibrinogenemia, BbetaGly15Cys (Hamamatsu II).
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2009;20(8):726-32.
2009: Yuka Kamijyo; Masako Hirota-Kawadobora; Noriko Fujihara; Saki Wakabayashi; Kazuyuki Matsuda; Kazuyoshi Yamauchi; Fumiko Terasawa; Nobuo Okumura; Takayuki Honda
[Functional analysis of heterozygous plasma dysfibrinogens derived from two families of gammaArg275Cys and three families of gammaArg275His, and haplotype analysis for these families].
Rinsho byori. The Japanese journal of clinical pathology 2009;57(7):651-8.
2009: Ayumi Haneishi; Fumiko Terasawa; Noriko Fujihara; Kazuyoshi Yamauchi; Nobuo Okumura; Tsutomu Katsuyama
Recombinant variant fibrinogens substituted at residues gamma326Cys and gamma339Cys demonstrated markedly impaired secretion of assembled fibrinogen.
Thrombosis research 2009;124(3):368-72.
2009: Nobuo Okumura; Ayumi Haneishi; Fumiko Terasawa
Citrullinated fibrinogen shows defects in FPA and FPB release and fibrin polymerization catalyzed by thrombin.
Clinica chimica acta; international journal of clinical chemistry 2009;401(1-2):119-23.
2008: Saki Wakabayashi; Shinsuke Ishikawa; Masako Hirota-Kawadobora; Noriko Fujihara; Yuka Kamijyo; Kazuyoshi Yamauchi; Fumiko Terasawa; Nobuo Okumura; Tsutomu Katsuyama
[Analysis of antibody reactivity for FDP D-dimer fragments by Western blotting].
Rinsho byori. The Japanese journal of clinical pathology 2008;56(6):449-54.
2007: Nobuo Okumura; Fumiko Terasawa; A Haneishi; Noriko Fujihara; Masako Hirota-Kawadobora; Kazuyoshi Yamauchi; H Ota; Susan T Lord
B:b interactions are essential for polymerization of variant fibrinogens with impaired holes 'a'.
Journal of thrombosis and haemostasis : JTH 2007;5(12):2352-9.
2007: Masako Hirota-Kawadobora; Shinsuke Ishikawa; Noriko Fujihara; Saki Wakabayashi; Yuka Kamijo; Kazuyoshi Yamauchi; Fumiko Terasawa; Nobuo Okumura; Tsutomu Katsuyama
[Analysis of hypofibrinogenemias found on routine coagulation screening tests and identification of heterozygous dysfibrinogenemia or fibrinogen deficiency].
Rinsho byori. The Japanese journal of clinical pathology 2007;55(11):989-95.
2007: Eiichiro Mawatari; Minoru Hongo; Akio Sakai; Fumiko Terasawa; Masafumi Takahashi; Yoshikazu Yazaki; Osamu Kinoshita; Uichi Ikeda
Amlodipine prevents monocrotaline-induced pulmonary arterial hypertension and prolongs survival in rats independent of blood pressure lowering.
Clinical and experimental pharmacology & physiology 2007;34(7):594-600.
2006: Satomi Kani; Fumiko Terasawa; Kazuyoshi Yamauchi; Minoru Tozuka; Nobuo Okumura
Analysis of fibrinogen variants at gamma387Ile shows that the side chain of gamma387 and the tertiary structure of the gammaC-terminal tail are important not only for assembly and secretion of fibrinogen but also for lateral aggregation of protofibrils and XIIIa-catalyzed gamma-gamma dimer formation.
Blood 2006;108(6):1887-94.
2006: Nobuo Okumura; Fumiko Terasawa; Masako Hirota-Kawadobora; Kazuyoshi Yamauchi; Kayoko Nakanishi; Shuichi Shiga; Satoshi Ichiyama; Megumu Saito; Masahiko Kawai; Tatsutoshi Nakahata
A novel variant fibrinogen, deletion of Bbeta111Ser in coiled-coil region, affecting fibrin lateral aggregation.
Clinica chimica acta; international journal of clinical chemistry 2006;365(1-2):160-7.
2006: Kiyotaka Fujita; Hirohisa Sato; Fumiko Kameko; Fumiko Terasawa; Nobuo Okumura; Mitsutoshi Sugano; Kazuyoshi Yamauchi; Masato Maekawa; Ikunosuke Sakurabayashi
An immunoglobulin A1 that inhibits lactate dehydrogenase activity, with reversal of inhibition by addition of NADH.
Annals of clinical and laboratory science 2006;36(4):461-8.
2006: Fumiko Terasawa; Satomi Kani; Minoru Hongo; Nobuo Okumura
In vitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gammaAsn319, Asp320 deletion dysfibrinogen, Otsu I.
Thrombosis research 2006;118(5):651-61.
2005: Minoru Hongo; Eiichiro Mawatari; Akio Sakai; Zonghai Ruan; Tomonobu Koizumi; Fumiko Terasawa; Yoshikazu Yazaki; Osamu Kinoshita; Uichi Ikeda; Toshishige Shibamoto
Effects of nicorandil on monocrotaline-induced pulmonary arterial hypertension in rats.
Journal of cardiovascular pharmacology 2005;46(4):452-8.
2005: Satomi Kani; Fumiko Terasawa; Susan T Lord; Minoru Tozuka; Hiroyoshi Ota; Nobuo Okumura; Tsutomu Katsuyama
In vitro expression demonstrates impaired secretion of the gammaAsn319, Asp320 deletion variant fibrinogen.
Thrombosis and haemostasis 2005;94(1):53-9.
2005: Masako Hirota-Kawadobora; Satomi Kani; Fumiko Terasawa; Noriko Fujihara; Kazuyoshi Yamauchi; Minoru Tozuka; Nobuo Okumura
Functional analysis of recombinant Bbeta15C and Bbeta15A fibrinogens demonstrates that Bbeta15G residue plays important roles in FPB release and in lateral aggregation of protofibrils.
Journal of thrombosis and haemostasis : JTH 2005;3(5):983-90.
2005: Fumiko Terasawa; Kiyotaka Fujita; Nobuo Okumura
Residue gamma153Cys is essential for the formation of the complexes Aalphagamma and Bbetagamma, assembly intermediates for the AalphaBbetagamma complex and intact fibrinogen.
Clinica chimica acta; international journal of clinical chemistry 2005;353(1-2):157-64.
2004: Masako Hirota-Kawadobora; Fumiko Terasawa; T Suzuki; Minoru Tozuka; K Sano; Nobuo Okumura
Comparison of thrombin-catalyzed fibrin polymerization and factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma 275C, gamma 275H, and gamma 275A.
Journal of thrombosis and haemostasis : JTH 2004;2(8):1359-67.
2004: Nobuo Okumura; Oleg V Gorkun; Fumiko Terasawa; Susan T Lord
Substitution of the gamma-chain Asn308 disturbs the D:D interface affecting fibrin polymerization, fibrinopeptide B release, and FXIIIa-catalyzed cross-linking.
Blood 2004;103(11):4157-63.
2004: S Ishikawa; Masako Hirota-Kawadobora; Minoru Tozuka; K Ishii; Fumiko Terasawa; Nobuo Okumura
Recombinant fibrinogen, gamma275Arg-->Cys, exhibits formation of disulfide bond with cysteine and severely impaired D:D interactions.
Journal of thrombosis and haemostasis : JTH 2004;2(3):468-75.
2003: Eiji Hironaka; Minoru Hongo; Akio Sakai; Eiichiro Mawatari; Fumiko Terasawa; Nobuo Okumura; Akie Yamazaki; Yoshihisa Ushiyama; Yoshikazu Yazaki; Osamu Kinoshita
Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats.
Cardiovascular research 2003;60(3):692-9.
2003: Fumiko Terasawa; Kelly A Hogan; Satomi Kani; Masaya Hirose; Yutaka Eguchi; Yoichi Noda; Minoru Hongo; Nobuo Okumura
Fibrinogen Otsu I:A gammaAsn319,Asp320 deletion dysfibrinogen identified in an asymptomatic pregnant woman.
Thrombosis and haemostasis 2003;90(4):757-8.
2003: Kiyotaka Fujita; Linda K Curtiss; Ikunosuke Sakurabayashi; Fumiko Kameko; Nobuo Okumura; Fumiko Terasawa; Minoru Tozuka; Tsutomu Katsuyama
Identification and properties of glycated monoclonal IgA that affect the fructosamine assay.
Clinical chemistry 2003;49(5):805-8.
2003: Masako Hirota-Kawadobora; Fumiko Terasawa; Osamu Yonekawa; N Sahara; E Shimizu; Nobuo Okumura; Tsutomu Katsuyama; H Shigematsu
Fibrinogens Kosai and Ogasa: Bbeta15Gly-->Cys (GGT-->TGT) substitution associated with impairment of fibrinopeptide B release and lateral aggregation.
Journal of thrombosis and haemostasis : JTH 2003;1(2):275-83.
2003: Fumiko Terasawa; Masako Hirota-Kawadobora; Hikaru Kobayashi; Hiroshi Saito; Minoru Tozuka; Nobuo Okumura
The Aalpha-chain 6Ile/Val polymorphism is not associated with plasma fibrinogen levels in Japanese.
Thrombosis research 2003;112(4):257-9.
2002: Nobuo Okumura; Fumiko Terasawa; Kiyotaka Fujita; Noriko Fujihara; Minoru Tozuka; Chang-Sung Koh
Evidence that heterodimers exist in the fibrinogen Matsumoto II (gamma308N-->K) proband and participate in fibrin fiber formation.
Thrombosis research 2002;107(3-4):157-62.
2002: Nobuo Okumura; Fumiko Terasawa; Hitoshi Tanaka; Masako Hirota; Hiroyoshi Ota; Kiyoshi Kitano; Kendo Kiyosawa; Susan T Lord
Analysis of fibrinogen gamma-chain truncations shows the C-terminus, particularly gammaIle387, is essential for assembly and secretion of this multichain protein.
Blood 2002;99(10):3654-60.
2002: Masako Hirota-Kawadobora; Minoru Tozuka; Kazuyoshi Yamauchi; Eiko Hidaka; Ichiro Ueno; Mitsutoshi Sugano; Fumiko Terasawa; Nobuo Okumura; Tsutomu Katsuyama; Hidekazu Shigematsu
Quantitative RT-PCR analysis demonstrates that synthesis of the recombinant fibrinogen is dependent on the transcription and synthesis of gamma-chain.
Clinica chimica acta; international journal of clinical chemistry 2002;319(1):67-73.
2001: Nobuo Okumura; Fumiko Terasawa; Osamu Yonekawa; E Hamada; H Kaneko
Hypofibrinogenemia associated with a heterozygous C-->T nucleotide substitution at position -1138 BP of the 5'-flanking region of the fibrinogen A alpha-chain gene.
Annals of the New York Academy of Sciences 2001;936():526-30.
2001: H Tanaka; Fumiko Terasawa; T Ito; S Tokunaga; Fumihiro Ishida; Kiyoshi Kitano; K Kiyosawa; Nobuo Okumura
Fibrinogen Matsumoto V: a variant with Aalpha19 Arg-->Gly (AGG-->GGG). Comparison between fibrin polymerization stimulated by thrombin or reptilase and fibrin monomer polymerization.
Thrombosis and haemostasis 2001;85(1):108-13.
2000: N Okumura; Fumiko Terasawa; K Fujita; Minoru Tozuka; H Ota; Tsutomu Katsuyama
Difference in electrophoretic mobility and plasmic digestion profile between four recombinant fibrinogens, gamma 308K, gamma 308I, gamma 308A, and wild type (gamma 308N).
Electrophoresis 2000;21(12):2309-15.
2000: Fumiko Terasawa; K Fujita; Minoru Tozuka; Hiroyoshi Ota; T Katsuyama; Nobuo Okumura
Identification of a dysfibrinogen, the substitution of gamma308Asn(AAT) to Lys(AAG), using coagulation tests, immunoblot analysis, and allele-specific polymerase chain reaction.
Clinica chimica acta; international journal of clinical chemistry 2000;295(1-2):77-85.
2000: Kelly A Hogan; Susan T Lord; Nobuo Okumura; Fumiko Terasawa; Dennis K Galanakis; I Scharrer; Oleg V Gorkun
A functional assay suggests that heterodimers exist in two C-terminal gamma-chain dysfibrinogens: Matsumoto I and Vlissingen/Frankfurt IV.
Thrombosis and haemostasis 2000;83(4):592-7.
1999: Fumiko Terasawa; N Okumura; K Kitano; N Hayashida; M Shimosaka; M Okazaki; Susan T Lord
Hypofibrinogenemia associated with a heterozygous missense mutation gamma153Cys to arg (Matsumoto IV): in vitro expression demonstrates defective secretion of the variant fibrinogen.
Blood 1999;94(12):4122-31.
1999: N Okumura; Fumiko Terasawa; Ichiro Ueno; K Oki; K Yamauchi; H Hidaka; Minoru Tozuka; M Okura; Tsutomu Katsuyama
Genetic analyses in homozygous and heterozygous variants of lactate dehydrogenase-B (H) subunit--LD-B Matsumoto I and II (LD-B W323R).
Clinica chimica acta; international journal of clinical chemistry 1999;287(1-2):163-71.
1999: Fumiko Terasawa; N Okumura; Y Higuchi; S Ishikawa; Minoru Tozuka; Fumihiro Ishida; K Kitano; T Katsuyama
Fibrinogen Matsumoto III: a variant with gamma275 Arg-->Cys (CGC-->TGC)--comparison of fibrin polymerization properties with those of Matsumoto I (gamma364 Asp-->His) and Matsumoto II (gamma308 Asn-->Lys).
Thrombosis and haemostasis 1999;81(5):763-6.
1996: N Okumura; K Furihata; Fumiko Terasawa; S Ishikawa; Ichiro Ueno; Tsutomu Katsuyama
Fibrinogen Matsumoto II: gamma 308 Asn-->Lys (AAT-->AAG) mutation associated with bleeding tendency.
British journal of haematology 1996;94(3):526-8.
1996: Fumiko Terasawa; Y Sasaki; S Ishikawa; R Nakagoshi; K Furihata; Tsutomu Katsuyama; N Okumura
[Comparison of coagulation screening test results in two cases having dysfibrinogen].
Rinsho byori. The Japanese journal of clinical pathology 1996;44(8):791-6.
1996: N Okumura; K Furihata; Fumiko Terasawa; R Nakagoshi; Ichiro Ueno; Tsutomu Katsuyama
Fibrinogen Matsumoto I: a gamma 364 Asp-->His (GAT-->CAT) substitution associated with defective fibrin polymerization.
Thrombosis and haemostasis 1996;75(6):887-91.
1995: N Okumura; A Matsuzawa; Fumiko Terasawa; Y Sasaki; R Nakagoshi; S Ishikawa; Yasuhiko Hashikura; H Matsunami; S Kawasaki; M Makuuchi
[Changes in coagulation parameters during the clinical courses of recipients of living-related partial liver transplantation].
Rinsho byori. The Japanese journal of clinical pathology 1995;43(8):829-35.
1995: N Okumura; A Matsuzawa; Fumiko Terasawa; M Kameko; Y Sasaki; R Nakagoshi; S Ishikawa; Yasuhiko Hashikura; H Matsunami; S Kawasaki
[Studies on the blood coagulation factor XIII in patients with increased levels of FDP D-dimer].
Rinsho byori. The Japanese journal of clinical pathology 1995;43(3):269-74.