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Cox Terhorst

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Ashley T Martino; Federico Mingozzi; David A Ostrov; Arun Srivastava; Cox Terhorst; Shangzhen Zhou; Etiena Basner-Tschakarjan; Hildegund C J Ertl; Jonathan D Finn; Katherine A High; Christian Hinderer; David M Markusic; Roland W Herzog
Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells.
Sun-Young Chang; Hao-Sen Chiang; Carmen Alonso Cotoner; Bayasi Guleng; Christopher L Karp; Mi-Na Kweon; Gongxian Liao; Michael O'Keeffe; Arlene H Sharpe; Joo-Hye Song; Cox Terhorst; Yun Zhao; Seiji Arihiro; Atul Bhan; Hans-Christian Reinecker
Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation.
Jordi Sintes; Cox Terhorst; Xavier Romero Ros; Ana Angulo; Ricardo Bastos; Marta Cuenca; Pablo Engel
Cutting edge: Ly9 (CD229), a SLAM family receptor, negatively regulates the development of thymic innate memory-like CD8+ T and invariant NKT cells.

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2013: Ashley T Martino; Federico Mingozzi; David A Ostrov; Arun Srivastava; Cox Terhorst; Shangzhen Zhou; Etiena Basner-Tschakarjan; Hildegund C J Ertl; Jonathan D Finn; Katherine A High; Christian Hinderer; David M Markusic; Roland W Herzog
Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells.
Blood 2013;121(12):2224-33.
2013: Sun-Young Chang; Hao-Sen Chiang; Carmen Alonso Cotoner; Bayasi Guleng; Christopher L Karp; Mi-Na Kweon; Gongxian Liao; Michael O'Keeffe; Arlene H Sharpe; Joo-Hye Song; Cox Terhorst; Yun Zhao; Seiji Arihiro; Atul Bhan; Hans-Christian Reinecker
Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation.
Immunity 2013;38(1):153-65.
2013: Jordi Sintes; Cox Terhorst; Xavier Romero Ros; Ana Angulo; Ricardo Bastos; Marta Cuenca; Pablo Engel
Cutting edge: Ly9 (CD229), a SLAM family receptor, negatively regulates the development of thymic innate memory-like CD8+ T and invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(1):21-6.
2012: Boaz van Driel; Guoxing Wang; Ninghai Wang; Veronica Azcutia; Scott B Berger; Atul K Bhan; Rene de Waal Malefyt; William A Faubion; Matthew Grisham; Gongxian Liao; Francis W Luscinskas; Erica M Magelky; Monika Manocha; Emiko Mizoguchi; Michael S O'Keeffe; Hans-Christian Reinecker; Xavier Romero Ros; Cox Terhorst
Signaling lymphocyte activation molecule regulates development of colitis in mice.
Gastroenterology 2012;143(6):1544-1554.e7.
2012: Madhumouli Chatterjee; Christian Hedrich; Christina Ioannidis; Thomas Rauen; Cox Terhorst; George C Tsokos
CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORγt recruitment to the IL17A promoter in human T lymphocytes.
The Journal of biological chemistry 2012;287(45):38168-77.
2012: Kara L Conway; Agnès Gardet; Gautam Goel; Monika Manocha; Emiko Mizoguchi; Harry Sokol; Cox Terhorst; Atul K Bhan; Ramnik J Xavier
p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(7):3631-40.
2012: Cynthia Detre; Natividad Garrido-Mesa; Marton Keszei; Katalin Kis-Toth; Elizabeth A Leadbetter; Amma F Agyemang; Gurdyal S Besra; Michael C Carroll; Wilson Castro; George C Tsokos; Natacha Veerapen; Ninghai Wang; Cox Terhorst
SAP expression in invariant NKT cells is required for cognate help to support B-cell responses.
Blood 2012;120(1):122-9.
2012: Guoxing Wang; Ninghai Wang; Ana C Abadía-Molina; Marta Aleman; Scott B Berger; Cynthia Detre; Manuel Fresno; Gongxian Liao; Elena Maganto-García; Michael S O'Keeffe; Domingo I Rojas-Barros; Xavier Romero Ros; Cox Terhorst
Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):5829-32.
2012: Chunyan Ma; Michael O'Keeffe; Guoxing Wang; Ninghai Wang; Cynthia Detre; Cox Terhorst
Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex.
The Journal of biological chemistry 2012;287(22):18359-65.
2012: Lisa S Westerberg; Cox Terhorst; Frederick W Alt; Marisa Baptista; Carin Dahlberg; Cynthia Detre; Michelle A Eston; Marton Keszei; Christopher J Moran; Luigi D Notarangelo; Scott B Snapper
Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function.
Blood 2012;119(17):3966-74.
2012: José C Crispín; Marton Keszei; Tanya N Mayadas; Florencia Rosetti; Cox Terhorst; Sokratis A Apostolidis; Ninghai Wang; George C Tsokos
Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(8):3567-71.
2012: Gongxian Liao; Scott B Berger; Atul K Bhan; Rene de Waal Malefyt; Cynthia Detre; Pablo Engel; Roland W Herzog; Cox Terhorst
Glucocorticoid-induced tumor necrosis factor receptor family-related protein regulates CD4(+)T cell-mediated colitis in mice.
Gastroenterology 2012;142(3):582-591.e8.
2012: Madhumouli Chatterjee; Christian Hedrich; Katalin Kis-Toth; Vasileios C Kyttaris; Thomas Rauen; Cox Terhorst; George C Tsokos
Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(3):1206-12.
2012: Jossela Calderón; JAVIER Carrión; Elena Maganto-Garcia; Carmen Punzón; Cox Terhorst; Manuel Fresno
The receptor Slamf1 on the surface of myeloid lineage cells controls susceptibility to infection by Trypanosoma cruzi.
PLoS pathogens 2012;8(7):e1002799.
2012: Brad E Hoffman; Cox Terhorst; Hildegund C J Ertl; Katherine A High; Roland W Herzog
Gene therapy research at the frontiers of viral immunology.
Frontiers in microbiology 2012;3():182.
2011: Erin E West; Ben Youngblood; Gabriela Alexe; Koichi Araki; Silvia Calpe; Gordon J Freeman; W Nicholas Haining; Hyun-Tak Jin; Bogumila T Konieczny; Wendy G Tan; Cox Terhorst; Rafi Ahmed
Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load.
Immunity 2011;35(2):285-98.
2011: Daniel R Brown; Silvia Calpe; Marton Keszei; Shannon McArdel; Cox Terhorst; Ninghai Wang; Arlene H Sharpe
Cutting edge: an NK cell-independent role for Slamf4 in controlling humoral autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):21-5.
2011: Brad E Hoffman; Gongxian Liao; Ashley T Martino; Brandon K Sack; Cox Terhorst; Ou Cao; Roland W Herzog
Nonredundant roles of IL-10 and TGF-β in suppression of immune responses to hepatic AAV-factor IX gene transfer.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(7):1263-72.
2011: Madhumouli Chatterjee; Katalin Kis-Toth; To-Ha Thai; Cox Terhorst; George C Tsokos
SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells.
Autoimmunity 2011;44(3):211-8.
2011: Marton Keszei; Cynthia Detre; Svend T Rietdijk; Pilar Muñoz; Xavier Romero; Scott B Berger; Silvia Calpe; Gongxian Liao; Wilson Castro; Aimee Julien; Ying-Yu Wu; Dong-Mi Shin; Jaime Sancho; Mercedes Zubiaur; Herbert C Morse; Laurence Morel; Pablo Engel; Ninghai Wang; Cox Terhorst
A novel isoform of the Ly108 gene ameliorates murine lupus.
The Journal of experimental medicine 2011;208(4):811-22.
2011: Marton Keszei; Yvette E Latchman; Vijay K Vanguri; Daniel R Brown; Cynthia Detre; Massimo Morra; Carolina V Arancibia; Elahna Paul; Silvia Calpe; Wilson Castro; Ninghai Wang; Cox Terhorst; Carolina V Arancibia-Carcamo; Arlene H Sharpe
Auto-antibody production and glomerulonephritis in congenic Slamf1-/- and Slamf2-/- [B6.129] but not in Slamf1-/- and Slamf2-/- [BALB/c.129] mice.
International immunology 2011;23(2):149-58.
2011: Árpád Lányi; Anna Orient; Zalán Péterfi; Eniko Petrovszki; Éva Rajnavölgyi; Tünde Simon; Gábor Sirokmány; Cox Terhorst; Mónika Baráth; Gábor Bőgel; László Buday; Katalin Kis-Tóth; Miklós Geiszt
The homolog of the five SH3-domain protein (HOFI/SH3PXD2B) regulates lamellipodia formation and cell spreading.
PloS one 2011;6(8):e23653.
2010: Ninghai Wang; Silvia Calpe; Jill Westcott; Wilson Castro; Chunyan Ma; Pablo Engel; John Schatzle; Cox Terhorst
Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(10):5683-7.
2010: Scott B Berger; Xavier Romero; Chunyan Ma; Guoxing Wang; William A Faubion; Gongxian Liao; Ewoud Compeer; Marton Keszei; Lucia Rameh; Ninghai Wang; Marianne Boes; Jose R Regueiro; Hans-Christian Reinecker; Cox Terhorst
SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages.
Nature immunology 2010;11(10):920-7.
2010: Jordi Sintes; Xavier Romero Ros; Jose de Salort; Cox Terhorst; Pablo Engel
Mouse CD84 is a pan-leukocyte cell-surface molecule that modulates LPS-induced cytokine secretion by macrophages.
Journal of leukocyte biology 2010;88(4):687-97.
2010: José C Crispín; Vasileios C Kyttaris; Cox Terhorst; George C Tsokos
T cells as therapeutic targets in SLE.
Nature reviews. Rheumatology 2010;6(6):317-25.
2010: Cynthia Detre; Marton Keszei; Xavier Romero; George C Tsokos; Cox Terhorst
SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions.
Seminars in immunopathology 2010;32(2):157-71.
2010: Steven A Porcelli; Michael B Brenner; Julia L Greenstein; Cox Terhorst; Steven P Balk; Paul A Bleicher
Recognition of Cluster of Differentiation 1 Antigens by Human CD4-CD8- CytolyticT Lymphocyte. Nature. 1989. 341: 447-450. 1989.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(7):3306-9.
2010: Gongxian Liao; Sushrusha Nayak; Jose R Regueiro; Scott B Berger; Cynthia Detre; Xavier Romero Ros; Rene de Waal Malefyt; Talal A Chatila; Roland W Herzog; Cox Terhorst
GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells.
International immunology 2010;22(4):259-70.
2010: Francesca Rucci; Luigi D Notarangelo; Alex Fazeli; Laura Patrizi; Thomas Hickernell; Tiziana Paganini; Kristen M Coakley; Cynthia Detre; Marton Keszei; Jolan E Walter; Lauren Feldman; Hwei-Ling Cheng; Pietro Luigi Poliani; Jing H Wang; Barbara B Balter; Mike Recher; Emma-Maria Andersson; Shan Zha; Silvia Giliani; Cox Terhorst; Frederick W Alt; Catherine T Yan
Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):3024-9.
2010: Betty Diamond; Charlotte Cunningham-Rundles; Alain Fischer; Raif Geha; Luigi Notarangelo; Hans Ochs; Daniel Rotrosen; Cox Terhorst
Josiah F. Wedgwood (1950-2009).
The Journal of allergy and clinical immunology 2010;125(2):506.
2009: T L Freitag; svend rietdijk; Y Junker; Y Popov; Atul K Bhan; Ciarán P Kelly; Cox Terhorst; Detlef Schuppan
Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice.
Gut 2009;58(12):1597-605.
2009: Monika Manocha; Svend Rietdijk; Rietdijk Svend; Amale Laouar; Liao Gongxian; Atul Bhan; Jannie Borst; Jannine Borst; Cox Terhorst; N Manjunath
Blocking CD27-CD70 costimulatory pathway suppresses experimental colitis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(1):270-6.
2009: Mario Cooper; Sushrusha Nayak; Brad E Hoffman; Cox Terhorst; Ou Cao; Roland W Herzog
Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.
Human gene therapy 2009;20(7):767-76.
2009: Ashley Martino; Sushrusha Nayak; Brad E Hoffman; Mario Cooper; Gongxian Liao; David M Markusic; Barry J Byrne; Cox Terhorst; Roland W Herzog
Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity.
PloS one 2009;4(8):e6376.
2008: Jordi Sintes; Xavier Romero Ros; Pedro Marin; Cox Terhorst; Pablo Engel
Differential expression of CD150 (SLAM) family receptors by human hematopoietic stem and progenitor cells.
Experimental hematology 2008;36(9):1199-204.
2008: Elena Maganto-Garcia; Carmen Punzon; Cox Terhorst; Manuel Fresno
Rab5 activation by Toll-like receptor 2 is required for Trypanosoma cruzi internalization and replication in macrophages.
Traffic (Copenhagen, Denmark) 2008;9(8):1299-315.
2008: Silvia Calpe; Ninghai Wang; Xavier Romero Ros; Scott B Berger; Arpad Lanyi; Pablo Engel; Cox Terhorst
The SLAM and SAP gene families control innate and adaptive immune responses.
Advances in immunology 2008;97():177-250.
2007: Wei Li; M Hanief Sofi; svend rietdijk; Ninghai Wang; Cox Terhorst; Cheong-Hee Chang
The SLAM-associated protein signaling pathway is required for development of CD4+ T cells selected by homotypic thymocyte interaction.
Immunity 2007;27(5):763-74.
2007: Klaus Griewank; Christine Borowski; svend rietdijk; Ninghai Wang; Aimee Julien; Datsen G Wei; Alusha A Mamchak; Cox Terhorst; Albert Bendelac
Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development.
Immunity 2007;27(5):751-62.
2007: Ou Cao; Eric Dobrzynski; Lixin Wang; Sushrusha Nayak; Bethany Mingle; Cox Terhorst; Roland W Herzog
Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer.
Blood 2007;110(4):1132-40.
2007: Gang Chen; Albert K Tai; Miao Lin; Francesca Chang; Cox Terhorst; Brigitte T Huber
Increased proliferation of CD8+ T cells in SAP-deficient mice is associated with impaired activation-induced cell death.
European journal of immunology 2007;37(3):663-74.
2006: Edgar Fernández-Malavé; Ninghai Wang; Manuel Pulgar; Wolfgang W A Schamel; Balbino Alarcon; Cox Terhorst
Overlapping functions of human CD3delta and mouse CD3gamma in alphabeta T-cell development revealed in a humanized CD3gamma-mouse.
Blood 2006;108(10):3420-7.
2006: Ninghai Wang; Monica Campo; Leon Ting; Caroline Fleming; Cox Terhorst; Patricia W Finn
The costimulatory molecule SLAM is critical for pulmonary allergic responses.
American journal of respiratory cell and molecular biology 2006;35(2):206-10.
2006: Bence Réthi; Péter Gogolák; Istvan Szatmari; Agota Veres; Erika Erdôs; Laszlo Nagy; Eva Rajnavölgyi; Cox Terhorst; Arpád Lányi
SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells.
Blood 2006;107(7):2821-9.
2006: Ana C Abadía-Molina; Honbing Ji; William A Faubion; Aimee Julien; Yvette Latchman; Hideo Yagita; Arlene Sharpe; Atul K Bhan; Cox Terhorst
CD48 controls T-cell and antigen-presenting cell functions in experimental colitis.
Gastroenterology 2006;130(2):424-34.
2006: Silvia Calpe; Erika Erdos; Liao Gongxian; Ninghai Wang; svend rietdijk; Maria Simarro; Beata Scholtz; Jill Mooney; Chang Hoon Lee; Min Sun Shin; Eva Rajnavölgyi; John Schatzle; Herbert C Morse; Cox Terhorst; Arpad Lanyi
Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters.
Immunogenetics 2006;58(1):15-25.
2005: F Stephen Laroux; Xavier Romero Ros; Lee Wetzler; Pablo Engel; Cox Terhorst
Cutting edge: MyD88 controls phagocyte NADPH oxidase function and killing of gram-negative bacteria.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5596-600.
2005: Nisha Nanda; Patrick Andre; Ming Bao; Karl Clauser; Francis DeGuzman; Duncan Howie; Pamela B Conley; Cox Terhorst; David R Phillips
Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling.
Blood 2005;106(9):3028-34.
2005: Gang Chen; Albert K Tai; Miao Lin; Francesca Chang; Cox Terhorst; Brigitte T Huber
Signaling lymphocyte activation molecule-associated protein is a negative regulator of the CD8 T cell response in mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2212-8.
2005: Mark J Kiel; Omer H Yilmaz; Toshihide Iwashita; Omer H Yilmaz; Cox Terhorst; Sean J Morrison
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells.
Cell 2005;121(7):1109-21.
2005: Duncan Howie; F Stephen Laroux; Massimo Morra; Abhay R Satoskar; Lucia E Rosas; William A Faubion; Aimee Julien; svend rietdijk; Anthony J Coyle; Christopher Fraser; Cox Terhorst
Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):5931-5.
2005: Ana C Abadía-Molina; Atsushi Mizoguchi; William A Faubion; Ype P de Jong; svend rietdijk; Martina Comiskey; Kareem Clarke; Atul K Bhan; Cox Terhorst
In vivo generation of oligoclonal colitic CD4+ T-cell lines expressing a distinct T-cell receptor Vbeta.
Gastroenterology 2005;128(5):1268-77.
2005: Massimo Morra; Robert A Barrington; Ana C Abadia-Molina; Susumo Okamoto; Aimee Julien; Charles Gullo; Anuj Kalsy; Matthew J Edwards; Gang Chen; Rosanne Spolski; Warren J Leonard; Brigitte T Huber; Persephone Borrow; Christine A Biron; Abhay R Satoskar; Michael C Carroll; Cox Terhorst
Defective B cell responses in the absence of SH2D1A.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(13):4819-23.
2005: Brian Chung; Ala Aoukaty; Jan P Dutz; Cox Terhorst; Rusung Tan
Signaling lymphocytic activation molecule-associated protein controls NKT cell functions.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3153-7.
2005: Timothy J Vyse; Angela M Richardson; Emily Walsh; Lisa Farwell; Mark J Daly; Cox Terhorst; John D Rioux
Mapping autoimmune disease genes in humans: lessons from IBD and SLE.
Novartis Foundation symposium 2005;267():94-107; discussion 107-12.
2004: Susumu Okamoto; Hongbin Ji; Duncan Howie; Kareem Clarke; Charles Gullo; Stephen Manning; Anthony J Coyle; Cox Terhorst
Expression of the SH2D1A gene is regulated by a combination of transcriptional and post-transcriptional mechanisms.
European journal of immunology 2004;34(11):3176-86.
2004: Pedro Roda-Navarro; María Mittelbrunn; Mara Ortega; Duncan Howie; Cox Terhorst; Francisco Sánchez-Madrid; Elena Fernández-Ruiz
Dynamic redistribution of the activating 2B4/SAP complex at the cytotoxic NK cell immune synapse.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3640-6.
2004: Marc Schmidt-Supprian; Jane Tian; Hongbin Ji; Cox Terhorst; Atul K Bhan; Ethan P Grant; Manolis Pasparakis; Stefano Casola; Anthony J Coyle; Klaus Rajewsky
I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1612-9.
2004: Akira Hokama; Emiko Mizoguchi; Ken Sugimoto; Yasuyo Shimomura; Yosuke Tanaka; Masaru Yoshida; svend rietdijk; Ype P de Jong; Scott B Snapper; Cox Terhorst; Richard S Blumberg; Atsushi Mizoguchi
Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation.
Immunity 2004;20(6):681-93.
2004: William A Faubion; Ype P de Jong; Ana Abadia Molina; Hongbin Ji; Kareem Clarke; Baoping Wang; Emiko Mizoguchi; Stephen J Simpson; Atul K Bhan; Cox Terhorst
Colitis is associated with thymic destruction attenuating CD4+25+ regulatory T cells in the periphery.
Gastroenterology 2004;126(7):1759-70.
2004: Hong-bin Ji; Liao Gongxian; William A Faubion; Ana C Abadía-Molina; Cristina Cozzo; F Stephen Laroux; Andrew J Caton; Cox Terhorst
Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):5823-7.
2004: Ninghai Wang; Abhay R Satoskar; William A Faubion; Duncan Howie; Susumu Okamoto; Stefan Feske; Charles Gullo; Kareem Clarke; Miriam Rodriguez Sosa; Arlene H Sharpe; Cox Terhorst
The cell surface receptor SLAM controls T cell and macrophage functions.
The Journal of experimental medicine 2004;199(9):1255-64.
2004: Maria Simarro; Arpad Lanyi; Duncan Howie; Florence Poy; Joost Bruggeman; Michelle Choi; Janos Sumegi; Michael J Eck; Cox Terhorst
SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9.
International immunology 2004;16(5):727-36.
2004: Cathryn Nagler-Anderson; Atul K Bhan; Daniel K Podolsky; Cox Terhorst
Control freaks: immune regulatory cells.
Nature immunology 2004;5(2):119-22.
2004: Ype P de Jong; svend rietdijk; William A Faubion; Ana C Abadia-Molina; Kareem Clarke; Emiko Mizoguchi; Jane Tian; Tracy Delaney; Stephen Manning; Jose-Carlos Gutierrez-Ramos; Atul K Bhan; Anthony J Coyle; Cox Terhorst
Blocking inducible co-stimulator in the absence of CD28 impairs Th1 and CD25+ regulatory T cells in murine colitis.
International immunology 2004;16(2):205-13.
2003: Pablo Engel; Michael J Eck; Cox Terhorst
The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease.
Nature reviews. Immunology 2003;3(10):813-21.
2003: Betty Chan; Arpad Lanyi; Hyun Kyu Song; Jan Griesbach; Maria Simarro-Grande; Florence Poy; Duncan Howie; Janos Sumegi; Cox Terhorst; Michael J Eck
SAP couples Fyn to SLAM immune receptors.
Nature cell biology 2003;5(2):155-60.
2003: Atsushi Mizoguchi; Emiko Mizoguchi; Ype P de Jong; Hiroko Takedatsu; Frederic Preffer; Cox Terhorst; Atul K Bhan
Role of the CD5 molecule on TCR gammadelta T cell-mediated immune functions: development of germinal centers and chronic intestinal inflammation.
International immunology 2003;15(1):97-108.
2002: Hong-Bin Ji; Anita Gupta; Susumu Okamoto; Michael D Blum; Lujian Tan; Mary B Goldring; Elizabeth Lacy; Ananda L Roy; Cox Terhorst
T cell-specific expression of the murine CD3delta promoter.
The Journal of biological chemistry 2002;277(49):47898-906.
2002: Duncan Howie; Susumo Okamoto; svend rietdijk; Kareem Clarke; Ninghai Wang; Charles Gullo; Joost P Bruggeman; Stephen Manning; Anthony J Coyle; Edward Greenfield; Vijay K Kuchroo; Cox Terhorst
The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production.
Blood 2002;100(8):2899-907.
2002: Victoria Tovar; Juana M del Valle; Nuria Zapater; Margarita Martin; Xavier Romero Ros; Pilar Pizcueta; Jaime Bosch; Cox Terhorst; Pablo Engel
Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors.
Immunogenetics 2002;54(6):394-402.
2002: Janos Sumegi; Thomas A Seemayer; Dali Huang; Jack R Davis; Massimo Morra; Thomas G Gross; Luo Yin; Giovanni Romco; Eva Klein; Cox Terhorst; Arpad Lanyi
A spectrum of mutations in SH2D1A that causes X-linked lymphoproliferative disease and other Epstein-Barr virus-associated illnesses.
Leukemia & lymphoma 2002;43(6):1189-201.
2002: María Guirado; Isabel de Aós; Teresa Orta; Luis Rivas; Cox Terhorst; Mercedes Zubiaur; Jaime Sancho
Phosphorylation of the N-terminal and C-terminal CD3-epsilon-ITAM tyrosines is differentially regulated in T cells.
Biochemical and biophysical research communications 2002;291(3):574-81.
2002: Christopher C Fraser; Duncan Howie; Massimo Morra; Yubin Qiu; Curran Murphy; Qiong Shen; Jose-Carlos Gutierrez-Ramos; Anthony J Coyle; Gillian A Kingsbury; Cox Terhorst
Identification and characterization of SF2000 and SF2001, two new members of the immune receptor SLAM/CD2 family.
Immunogenetics 2002;53(10-11):843-50.
2002: Peter M Hwang; Chengjun Li; Massimo Morra; Jennifer Lillywhite; D Ranjith Muhandiram; Frank Gertler; Cox Terhorst; Lewis E Kay; Tony Pawson; Julie D Forman-Kay; Shun-Cheng Li
A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
The EMBO journal 2002;21(3):314-23.
2002: Duncan Howie; Maria Simarro; Joan Sayos; María Guirado; Jaime Sancho; Cox Terhorst
Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation.
Blood 2002;99(3):957-65.
2002: Emiko Mizoguchi; Atsushi Mizoguchi; Hiroko Takedatsu; Elke Cario; Ype P de Jong; Choon Jin Ooi; Ramnik Xavier; Cox Terhorst; Daniel K Podolsky; Atul K Bhan
Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice.
Gastroenterology 2002;122(1):134-44.
2001: Massimo Morra; J Lu; Florence Poy; M Martin; Joan Sayos; Silvia Calpe; Charles Gullo; Duncan Howie; svend rietdijk; A Thompson; Anthony J Coyle; C Denny; M B Yaffe; Pablo Engel; Michael J Eck; Cox Terhorst
Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.
The EMBO journal 2001;20(21):5840-52.
2001: Ype P de Jong; Ana C Abadia-Molina; Abhay R Satoskar; Kareem Clarke; svend rietdijk; William A Faubion; Emiko Mizoguchi; C N Metz; Mazen Alsahli; T ten Hove; Andrew C Keates; Jodi B Lubetsky; Richard J Farrell; Pierre Michetti; S J van Deventer; Elias Lolis; J R David; Atul K Bhan; Cox Terhorst; M A Sahli
Development of chronic colitis is dependent on the cytokine MIF.
Nature immunology 2001;2(11):1061-6.
2001: Massimo Morra; M Simarro-Grande; M Martin; A S Chen; Arpad Lanyi; O Silander; Silvia Calpe; J Davis; T Pawson; Michael J Eck; Janos Sumegi; Pablo Engel; S C Li; Cox Terhorst
Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients.
The Journal of biological chemistry 2001;276(39):36809-16.
2001: Kyoung-Jin Sohn; SA Shah; S Reid; Monica Choi; Julie Carrier; Martina Comiskey; Cox Terhorst; Young-In Kim
Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse.
Cancer research 2001;61(18):6912-7.
2001: Massimo Morra; O Silander; Silvia Calpe; M Choi; Hans C Oettgen; L Myers; A Etzioni; R Buckley; Cox Terhorst
Alterations of the X-linked lymphoproliferative disease gene SH2D1A in common variable immunodeficiency syndrome.
Blood 2001;98(5):1321-5.
2001: Ninghai Wang; Massimo Morra; Carl Wu; Charles Gullo; Duncan Howie; T Coyle; Pablo Engel; Cox Terhorst
CD150 is a member of a family of genes that encode glycoproteins on the surface of hematopoietic cells.
Immunogenetics 2001;53(5):382-94.
2001: J Sayós; M Martín; A Chen; Maria Simarro; Duncan Howie; Massimo Morra; Pablo Engel; Cox Terhorst
Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP.
Blood 2001;97(12):3867-74.
2001: Carl Wu; Khuong B Nguyen; Gary C Pien; Ninghai Wang; Charles Gullo; Duncan Howie; M R Sosa; M J Edwards; Persephone Borrow; Abhay R Satoskar; Arlene H Sharpe; Christine A Biron; Cox Terhorst
SAP controls T cell responses to virus and terminal differentiation of TH2 cells.
Nature immunology 2001;2(5):410-4.
2001: Claudia Veltkamp; Susan L Tonkonogy; Ype P de Jong; C Albright; Wetonia B Grenther; Edward Balish; Cox Terhorst; Ryan Sartor
Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg(epsilon26) mice.
Gastroenterology 2001;120(4):900-13.
2001: Massimo Morra; Duncan Howie; M S Grande; Joan Sayos; Ninghai Wang; Carl Wu; Pablo Engel; Cox Terhorst
X-linked lymphoproliferative disease: a progressive immunodeficiency.
Annual review of immunology 2001;19():657-82.
2000: J Sayós; Khuong B Nguyen; Carl Wu; Susan E Stepp; Duncan Howie; John Schatzle; Vinay Kumar; Christine A Biron; Cox Terhorst
Potential pathways for regulation of NK and T cell responses: differential X-linked lymphoproliferative syndrome gene product SAP interactions with SLAM and 2B4.
International immunology 2000;12(12):1749-57.
2000: Ype P de Jong; Martina Comiskey; S L Kalled; Emiko Mizoguchi; R A Flavell; Atul K Bhan; Cox Terhorst
Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administration.
Gastroenterology 2000;119(3):715-23.
2000: Carl Wu; Joan Sayos; Ninghai Wang; Duncan Howie; Anthony J Coyle; Cox Terhorst
Genomic organization and characterization of mouse SAP, the gene that is altered in X-linked lymphoproliferative disease.
Immunogenetics 2000;51(10):805-15.
2000: Duncan Howie; Joan Sayos; Cox Terhorst; Massimo Morra
The gene defective in X-linked lymphoproliferative disease controls T cell dependent immune surveillance against Epstein-Barr virus.
Current opinion in immunology 2000;12(4):474-8.
2000: Lawrence J Saubermann; P Beck; Ype P de Jong; Richard S Pitman; M S Ryan; H S Kim; Mark A Exley; Scott B Snapper; Steven P Balk; S J Hagen; O Kanauchi; Kazuhiro Motoki; T Sakai; Cox Terhorst; Yasuhiko Koezuka; Daniel K Podolsky; Richard S Blumberg
Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice.
Gastroenterology 2000;119(1):119-28.
2000: Stephen J Simpson; Ype P de Jong; Martina Comiskey; Cox Terhorst
Pathways of T cell pathology in models of chronic intestinal inflammation.
International reviews of immunology 2000;19(1):1-37.
1999: Florence Poy; M B Yaffe; Joan Sayos; K Saxena; Massimo Morra; Janos Sumegi; Lewis C Cantley; Cox Terhorst; Michael J Eck
Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Molecular cell 1999;4(4):555-61.
1999: Mercedes Zubiaur; María Guirado; Cox Terhorst; Fabio Malavasi; Jaime Sancho
The CD3-gamma delta epsilon transducing module mediates CD38-induced protein-tyrosine kinase and mitogen-activated protein kinase activation in Jurkat T cells.
The Journal of biological chemistry 1999;274(29):20633-42.
1999: CN Levelt; Ype P de Jong; Emiko Mizoguchi; C O'Farrelly; Atul K Bhan; Susumu Tonegawa; Cox Terhorst; Stephen J Simpson
High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5628-33.
1999: J She; MC Ruzek; P Velupillai; I de Aos; Baoping Wang; Donald A Harn; J Sancho; Christine A Biron; Cox Terhorst
Generation of antigen-specific cytotoxic T lymphocytes and regulation of cytokine production takes place in the absence of CD3zeta.
International immunology 1999;11(5):845-57.
1999: Baoping Wang; Ninghai Wang; C E Whitehurst; J She; J Chen; Cox Terhorst
T lymphocyte development in the absence of CD3 epsilon or CD3 gamma delta epsilon zeta.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):88-94.
1998: Ninghai Wang; Baoping Wang; M Salio; D Allen; J She; Cox Terhorst
Expression of a CD3 epsilon transgene in CD3 epsilon(null) mice does not restore CD3 gamma and delta expression but efficiently rescues T cell development from a subpopulation of prothymocytes.
International immunology 1998;10(12):1777-88.
1998: Fabienne Mackay; Jeffrey L Browning; P Lawton; SA Shah; Martina Comiskey; Atul K Bhan; Emiko Mizoguchi; Cox Terhorst; Stephen J Simpson
Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis.
Gastroenterology 1998;115(6):1464-75.
1998: J She; K Matsui; Cox Terhorst; S T Ju
Activation-induced apoptosis of mature T cells is dependent upon the level of surface TCR but not on the presence of the CD3 zeta ITAM.
International immunology 1998;10(11):1733-40.
1998: Baoping Wang; Ninghai Wang; M Salio; A Sharpe; D Allen; J She; Cox Terhorst
Essential and partially overlapping role of CD3gamma and CD3delta for development of alphabeta and gammadelta T lymphocytes.
The Journal of experimental medicine 1998;188(7):1375-80.
1998: Joan Sayos; Carl Wu; Massimo Morra; Ninghai Wang; X Zhang; D Allen; S van Schaik; L Notarangelo; R Geha; M G Roncarolo; Hans C Oettgen; Jan E de Vries; Gregorio Aversa; Cox Terhorst
The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.
Nature 1998;395(6701):462-9.
1998: Stephen J Simpson; Ype P de Jong; SA Shah; Martina Comiskey; Baoping Wang; JA Spielman; Eckhard R Podack; Emiko Mizoguchi; Atul K Bhan; Cox Terhorst
Consequences of Fas-ligand and perforin expression by colon T cells in a mouse model of inflammatory bowel disease.
Gastroenterology 1998;115(4):849-55.
1998: SA Shah; Stephen J Simpson; L F Brown; Martina Comiskey; Ype P de Jong; D Allen; Cox Terhorst
Development of colonic adenocarcinomas in a mouse model of ulcerative colitis.
Inflammatory bowel diseases 1998;4(3):196-202.
1998: Massimo Morra; Mercedes Zubiaur; Cox Terhorst; Jaime Sancho; Fabio Malavasi
CD38 is functionally dependent on the TCR/CD3 complex in human T cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(7):581-92.
1998: Stephen J Simpson; S Shah; Martina Comiskey; Ype P de Jong; Baoping Wang; Emiko Mizoguchi; Atul K Bhan; Cox Terhorst
T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells.
The Journal of experimental medicine 1998;187(8):1225-34.
1998: Stephen J Simpson; Ype P de Jong; Martina Comiskey; Cox Terhorst
T cells in mouse models of gut inflammation.
Chemical immunology 1998;71():118-38.
1997: I de Aós; M H Metzger; M Exley; C E Dahl; S Misra; Dexian Zheng; L Varticovski; Cox Terhorst; Jaime Sancho
Tyrosine phosphorylation of the CD3-epsilon subunit of the T cell antigen receptor mediates enhanced association with phosphatidylinositol 3-kinase in Jurkat T cells.
The Journal of biological chemistry 1997;272(40):25310-8.
1997: Mercedes Zubiaur; M Izquierdo; Cox Terhorst; Fabio Malavasi; Jaime Sancho
CD38 ligation results in activation of the Raf-1/mitogen-activated protein kinase and the CD3-zeta/zeta-associated protein-70 signaling pathways in Jurkat T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):193-205.
1997: Baoping Wang; Stephen J Simpson; Georg A Holländer; Cox Terhorst
Development and function of T lymphocytes and natural killer cells after bone marrow transplantation of severely immunodeficient mice.
Immunological reviews 1997;157():53-60.
1997: J She; Stephen J Simpson; A Gupta; Georg A Holländer; CN Levelt; C P Liu; D Allen; Nancy Van Houten; Baoping Wang; Cox Terhorst
CD16-expressing CD8alpha alpha+ T lymphocytes in the intestinal epithelium: possible precursors of Fc gammaR-CD8alpha alpha+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4678-87.
1997: Baoping Wang; J She; M Salio; D Allen; Elizabeth Lacy; N Lonberg; Cox Terhorst
CD3-epsilon overexpressed in prothymocytes acts as an oncogene.
Molecular medicine (Cambridge, Mass.) 1997;3(1):72-81.
1997: Stephen J Simpson; Georg A Holländer; Emiko Mizoguchi; D Allen; Atul K Bhan; Baoping Wang; Cox Terhorst
Expression of pro-inflammatory cytokines by TCR alpha beta+ and TCR gamma delta+ T cells in an experimental model of colitis.
European journal of immunology 1997;27(1):17-25.
1996: Baoping Wang; G A Hollander; A Nichogiannopoulou; Stephen J Simpson; J S Orange; Jose-Carlos Gutierrez-Ramos; Steven J Burakoff; C A Biron; Cox Terhorst
Natural killer cell development is blocked in the context of aberrant T lymphocyte ontogeny.
International immunology 1996;8(6):939-49.
1995: J S Orange; Baoping Wang; Cox Terhorst; Christine A Biron
Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration.
The Journal of experimental medicine 1995;182(4):1045-56.
1995: Stephen J Simpson; E Mizoguchi; D Allen; A K Bhan; Cox Terhorst
Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis.
European journal of immunology 1995;25(9):2618-25.
1995: Mark A Exley; T Wileman; B Mueller; Cox Terhorst
Evidence for multivalent structure of T-cell antigen receptor complex.
Molecular immunology 1995;32(11):829-39.
1995: P Mombaerts; Cox Terhorst; Tyler Jacks; Susumu Tonegawa; J Sancho
Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(16):7420-4.
1995: S P Balk; J E Polischuk; C Probert; C Stevens; E Ebert; J She; Cox Terhorst; Richard S Blumberg
Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain.
International immunology 1995;7(8):1237-41.
1995: Georg A Holländer; Stephen J Simpson; E Mizoguchi; A Nichogiannopoulou; J She; Jose-Carlos Gutierrez-Ramos; A K Bhan; Steven J Burakoff; Baoping Wang; Cox Terhorst
Severe colitis in mice with aberrant thymic selection.
Immunity 1995;3(1):27-38.
1995: S Simpson; Georg A Holländer; J She; C Levelt; M Huang; Cox Terhorst
Selection of peripheral and intestinal T lymphocytes lacking CD3 zeta.
International immunology 1995;7(2):287-93.
1995: Georg A Holländer; B Wang; A Nichogiannopoulou; P P Platenburg; W van Ewijk; Steven J Burakoff; Jose-Carlos Gutierrez-Ramos; Cox Terhorst
Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes.
Nature 1995;373(6512):350-3.
1995: B Müller; Laurence J N Cooper; Cox Terhorst
Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29).
Immunology letters 1995;44(2-3):97-103.
1994: HC Su; J S Orange; L D Fast; A T Chan; Stephen J Simpson; Cox Terhorst; Christine A Biron
IL-2-dependent NK cell responses discovered in virus-infected beta 2-microglobulin-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5674-81.
1994: R Franco; M E Peter; M S Choi; B Malissen; Jaime Sancho; Cox Terhorst
Characterization of the GTP/GDP binding site in the murine CD3-zeta polypeptide chain.
Immunology letters 1994;43(3):167-75.
1994: Baoping Wang; C Biron; J She; K Higgins; M J Sunshine; Elizabeth Lacy; N Lonberg; Cox Terhorst
A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9402-6.
1994: Mark A Exley; L Varticovski; M Peter; Jaime Sancho; Cox Terhorst
Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation.
The Journal of biological chemistry 1994;269(21):15140-6.
1994: A Gupta; Cox Terhorst
CD3 delta enhancer. CREB interferes with the function of a murine CD3-delta A binding factor (M delta AF).
Journal of immunology (Baltimore, Md. : 1950) 1994;152(8):3895-903.
1993: I J Molina; Jaime Sancho; Cox Terhorst; Fred S Rosen; Eileen Remold-O'Donnell
T cells of patients with the Wiskott-Aldrich syndrome have a restricted defect in proliferative responses.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(8):4383-90.
1993: C G Hall; Jaime Sancho; Cox Terhorst
Reconstitution of T cell receptor zeta-mediated calcium mobilization in nonlymphoid cells.
Science (New York, N.Y.) 1993;261(5123):915-8.
1993: T Wileman; L P Kane; J Young; G R Carson; Cox Terhorst
Associations between subunit ectodomains promote T cell antigen receptor assembly and protect against degradation in the ER.
The Journal of cell biology 1993;122(1):67-78.
1993: Jaime Sancho; R Franco; Talal A Chatila; C Hall; Cox Terhorst
The T cell receptor associated CD3-epsilon protein is phosphorylated upon T cell activation in the two tyrosine residues of a conserved signal transduction motif.
European journal of immunology 1993;23(7):1636-42.
1993: Jaime Sancho; M E Peter; R Franco; S Danielian; J S Kang; Remi Fagard; J Woods; J C Reed; M Kamoun; Cox Terhorst
Coupling of GTP-binding to the T cell receptor (TCR) zeta-chain with TCR-mediated signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(8 Pt 1):3230-42.
1993: M E Peter; J She; L A Huber; Cox Terhorst
Labeling of adenine and guanine nucleotide-binding proteins in permeabilized cells with in situ periodate-oxidized nucleotides.
Analytical biochemistry 1993;210(1):77-85.
1993: M E Peter; T Wileman; Cox Terhorst
Covalent binding of guanine nucleotides to the CD3-gamma chain of the T cell receptor/CD3 complex.
European journal of immunology 1993;23(2):461-6.
1993: Cox Terhorst; Mark A Exley; R Franco; C Hall; J Kang; B Mueller; Jaime Sancho; J She; T Wileman
Coupling of T-cell activation with T-cell receptor assembly.
The Year in immunology 1993;7():1-24.
1992: B Müller; Laurence J N Cooper; Cox Terhorst
Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29.
European journal of immunology 1992;22(6):1621-5.
1992: Jaime Sancho; Jeffrey A Ledbetter; M S Choi; Steven B Kanner; J P Deans; Cox Terhorst
CD3-zeta surface expression is required for CD4-p56lck-mediated upregulation of T cell antigen receptor-CD3 signaling in T cells.
The Journal of biological chemistry 1992;267(11):7871-9.
1992: M E Peter; C Hall; A Rühlmann; Jaime Sancho; Cox Terhorst
The T-cell receptor zeta chain contains a GTP/GDP binding site.
The EMBO journal 1992;11(3):933-41.
1992: Jaime Sancho; L B Silverman; E Castigli; D Ahern; A P Laudano; Cox Terhorst; Raif S Geha; Talal A Chatila
Developmental regulation of transmembrane signaling via the T cell antigen receptor/CD3 complex in human T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(5):1315-21.
1991: Richard S Blumberg; Cox Terhorst; P Bleicher; F V McDermott; C H Allan; S B Landau; J S Trier; S P Balk
Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(8):2518-24.
1991: T Wileman; L P Kane; Cox Terhorst
Degradation of T-cell receptor chains in the endoplasmic reticulum is inhibited by inhibitors of cysteine proteases.
Cell regulation 1991;2(9):753-65.
1991: Mark A Exley; Cox Terhorst; T Wileman
Structure, assembly and intracellular transport of the T cell receptor for antigen.
Seminars in immunology 1991;3(5):283-97.
1991: C Hall; Ben Berkhout; B Alarcon; Jaime Sancho; T Wileman; Cox Terhorst
Requirements for cell surface expression of the human TCR/CD3 complex in non-T cells.
International immunology 1991;3(4):359-68.
1991: Balbino Alarcon; Steven C Ley; F Sánchez-Madrid; Richard S Blumberg; S T Ju; Manuel Fresno; Cox Terhorst
The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes.
The EMBO journal 1991;10(4):903-12.
1991: T Wileman; L P Kane; G R Carson; Cox Terhorst
Depletion of cellular calcium accelerates protein degradation in the endoplasmic reticulum.
The Journal of biological chemistry 1991;266(7):4500-7.
1991: Richard S Blumberg; Jaime Sancho; Steven C Ley; F V McDermott; K N Tan; J Breitmeyer; Cox Terhorst
Genetic reconstitution of the T cell receptor (TcR) alpha/beta heterodimer restores the association of CD3 zeta 2 with the TcR/CD3 complex.
European journal of immunology 1991;21(2):473-81.
1991: S P Balk; Paul Bleicher; Cox Terhorst
Isolation and expression of cDNA encoding the murine homologues of CD1.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(2):768-74.
1990: Paul Bleicher; S P Balk; S J Hagen; Richard S Blumberg; T J Flotte; Cox Terhorst
Expression of murine CD1 on gastrointestinal epithelium.
Science (New York, N.Y.) 1990;250(4981):679-82.
1990: T Wileman; G R Carson; F F Shih; M F Concino; Cox Terhorst
The transmembrane anchor of the T-cell antigen receptor beta chain contains a structural determinant of pre-Golgi proteolysis.
Cell regulation 1990;1(12):907-19.
1990: Richard S Blumberg; Steven C Ley; Jaime Sancho; N Lonberg; Elizabeth Lacy; F McDermott; V Schad; J L Greenstein; Cox Terhorst
Structure of the T-cell antigen receptor: evidence for two CD3 epsilon subunits in the T-cell receptor-CD3 complex.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(18):7220-4.
1990: Richard S Blumberg; B Alarcon; Jaime Sancho; F V McDermott; P Lopez; J Breitmeyer; Cox Terhorst
Assembly and function of the T cell antigen receptor. Requirement of either the lysine or arginine residues in the transmembrane region of the alpha chain.
The Journal of biological chemistry 1990;265(23):14036-43.
1990: T A Reno; S Ley; E Sugiyama; A Cantagrel; Richard S Blumberg; Joseph V Bonventre; Cox Terhorst; E T Yeh
Defects in signal transduction caused by a T cell receptor beta chain substitution.
European journal of immunology 1990;20(7):1417-22.
1990: T Wileman; G R Carson; M Concino; A Ahmed; Cox Terhorst
The gamma and epsilon subunits of the CD3 complex inhibit pre-Golgi degradation of newly synthesized T cell antigen receptors.
The Journal of cell biology 1990;110(4):973-86.
1990: R C Wong; Eileen Remold-O'Donnell; Donata Vercelli; Jaime Sancho; Cox Terhorst; Fred S Rosen; Raif S Geha; Talal A Chatila
Signal transduction via leukocyte antigen CD43 (sialophorin). Feedback regulation by protein kinase C.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(4):1455-60.
1990: T Wileman; C Pettey; Cox Terhorst
Recognition for degradation in the endoplasmic reticulum and lysosomes prevents the transport of single TCR beta and CD3 delta subunits of the T-cell antigen receptor to the surface of cells.
International immunology 1990;2(8):743-54.
1990: B Alarcon; Cox Terhorst; A Arnaiz-Villena; P Perez-Aciego; J R Regueiro
Congenital T-cell receptor immunodeficiencies in man.
Immunodeficiency reviews 1990;2(1):1-16.
1990: K Georgopoulos; D Galson; Cox Terhorst
Tissue-specific nuclear factors mediate expression of the CD3 delta gene during T cell development.
The EMBO journal 1990;9(1):109-15.
1989: Jaime Sancho; Talal A Chatila; R C Wong; C Hall; Richard S Blumberg; B Alarcon; Raif S Geha; Cox Terhorst
T-cell antigen receptor (TCR)-alpha/beta heterodimer formation is a prerequisite for association of CD3-zeta 2 into functionally competent TCR.CD3 complexes.
The Journal of biological chemistry 1989;264(34):20760-9.
1989: Steven C Ley; K N Tan; R Kubo; M S Sy; Cox Terhorst
Surface expression of CD3 in the absence of T cell receptor (TcR): evidence for sorting of partial TcR/CD3 complexes in a post-endoplasmic reticulum compartment.
European journal of immunology 1989;19(12):2309-17.
1989: Steven A Porcelli; Michael B Brenner; J L Greenstein; S P Balk; Cox Terhorst; Paul Bleicher
Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes.
Nature 1989;341(6241):447-50.
1989: Hans Clevers; N Lonberg; S Dunlap; Elizabeth Lacy; Cox Terhorst
An enhancer located in a CpG-island 3' to the TCR/CD3-epsilon gene confers T lymphocyte-specificity to its promoter.
The EMBO journal 1989;8(9):2527-35.
1989: L B Silverman; R C Wong; Eileen Remold-O'Donnell; Donata Vercelli; Jaime Sancho; Cox Terhorst; Fred S Rosen; Raif S Geha; Talal A Chatila
Mechanism of mononuclear cell activation by an anti-CD43 (sialophorin) agonistic antibody.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4194-200.
1989: Talal A Chatila; R Wong; M Young; Richard A Miller; Cox Terhorst; Raif S Geha
An immunodeficiency characterized by defective signal transduction in T lymphocytes.
The New England journal of medicine 1989;320(11):696-702.
1989: S P Balk; Paul Bleicher; Cox Terhorst
Isolation and characterization of a cDNA and gene coding for a fourth CD1 molecule.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(1):252-6.
1988: B Alarcon; José R Regueiro; A Arnaiz-Villena; Cox Terhorst
Familial defect in the surface expression of the T-cell receptor-CD3 complex.
The New England journal of medicine 1988;319(18):1203-8.
1988: H C Clevers; S Dunlap; T E Wileman; Cox Terhorst
Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(21):8156-60.
1988: Hans Clevers; S Dunlap; Haruo Saito; K Georgopoulos; T Wileman; Cox Terhorst
Characterization and expression of the murine CD3-epsilon gene.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8623-7.
1988: K Georgopoulos; P van den Elsen; E Bier; A Maxam; Cox Terhorst
A T cell-specific enhancer is located in a DNase I-hypersensitive area at the 3' end of the CD3-delta gene.
The EMBO journal 1988;7(8):2401-7.
1988: Ben Berkhout; B Alarcon; Cox Terhorst
Transfection of genes encoding the T cell receptor-associated CD3 complex into COS cells results in assembly of the macromolecular structure.
The Journal of biological chemistry 1988;263(17):8528-36.
1988: Ben Berkhout; C Hall; Cox Terhorst
Complete cDNA sequence coding for the human T cell receptor alpha chain HPB-ALL.
Nucleic acids research 1988;16(11):5209.
1988: Hans Clevers; S Dunlap; Cox Terhorst
The transmembrane orientation of the epsilon chain of the TcR/CD3 complex.
European journal of immunology 1988;18(5):705-10.
1988: Man-Sun Sy; P T Wang; S T Ju; K M Weston; B Alarcon; Cox Terhorst; E T Yeh
Abnormal T cells from MRL/Mp-lpr/lpr mice do not respond to anti-T-cell-receptor antibody or tumor promoter and calcium ionophore A23187 despite the presence of the T-cell-receptor complex and protein kinase c.
Cellular immunology 1988;113(1):82-94.
1988: B Alarcon; Ben Berkhout; J Breitmeyer; Cox Terhorst
Assembly of the human T cell receptor-CD3 complex takes place in the endoplasmic reticulum and involves intermediary complexes between the CD3-gamma.delta.epsilon core and single T cell receptor alpha or beta chains.
The Journal of biological chemistry 1988;263(6):2953-61.
1988: Hans Clevers; B Alarcon; T Wileman; Cox Terhorst
The T cell receptor/CD3 complex: a dynamic protein ensemble.
Annual review of immunology 1988;6():629-62.
1987: Haruo Saito; T Koyama; K Georgopoulos; Hans Clevers; W G Haser; T LeBien; Susumu Tonegawa; Cox Terhorst
Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):9131-4.
1987: D P Gold; Hans Clevers; B Alarcon; S Dunlap; J Novotny; A F Williams; Cox Terhorst
Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7649-53.
1986: H Reiser; H Oettgen; E T Yeh; Cox Terhorst; M G Low; franccesca villella; Kenneth L Rock
Structural characterization of the TAP molecule: a phosphatidylinositol-linked glycoprotein distinct from the T cell receptor/T3 complex and Thy-1.
Cell 1986;47(3):365-70.
1986: P van den Elsen; K Georgopoulos; B A Shepley; Stuart H Orkin; Cox Terhorst
Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(9):2944-8.
1986: Cox Terhorst; J de Vries; K Georgopoulos; D Gold; H Oettgen; C Pettey; H Spits; David S Ucker; P van den Elsen; T Wileman
The T cell receptor/T3 complex.
The Year in immunology 1986;2():245-53.
1985: P van den Elsen; G Bruns; DS Gerhard; D Pravtcheva; C Jones; D Housman; F A Ruddle; Stuart H Orkin; Cox Terhorst
Assignment of the gene coding for the T3-delta subunit of the T3-T-cell receptor complex to the long arm of human chromosome 11 and to mouse chromosome 9.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(9):2920-4.
1985: P van den Elsen; B A Shepley; M Cho; Cox Terhorst
Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein.
Nature 1985;314(6011):542-4.
1984: P van den Elsen; B A Shepley; Jannie Borst; J E Coligan; A F Markham; Stuart H Orkin; Cox Terhorst
Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex.
Nature 1984;312(5993):413-8.