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Robert Terkeltaub

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H Ralph Schumacher; Jian Wang; Steven P Weinstein; George D Yancopoulos; James Clower; Robert R Evans; William Jennings; Kenneth G Saag; Robert Terkeltaub
Rilonacept (interleukin-1 trap) for prevention of gout flares during initiation of uric acid-lowering therapy: results from a phase III randomized, double-blind, placebo-controlled, confirmatory efficacy study.
Ru Liu-Bryan; Robert Terkeltaub
The growing array of innate inflammatory ignition switches in osteoarthritis.
Weifang Yu; Jagadeesha K Damanahalli; Ru Liu-Bryan; Stephanie Stevens; Robert Terkeltaub
RAGE signaling mediates post-injury arterial neointima formation by suppression of liver kinase B1 and AMPK activity.

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2012: H Ralph Schumacher; Jian Wang; Steven P Weinstein; George D Yancopoulos; James Clower; Robert R Evans; William Jennings; Kenneth G Saag; Robert Terkeltaub
Rilonacept (interleukin-1 trap) for prevention of gout flares during initiation of uric acid-lowering therapy: results from a phase III randomized, double-blind, placebo-controlled, confirmatory efficacy study.
Arthritis care & research 2012;64(10):1462-70.
2012: Ru Liu-Bryan; Robert Terkeltaub
The growing array of innate inflammatory ignition switches in osteoarthritis.
Arthritis and rheumatism 2012;64(7):2055-8.
2012: Weifang Yu; Jagadeesha K Damanahalli; Ru Liu-Bryan; Stephanie Stevens; Robert Terkeltaub
RAGE signaling mediates post-injury arterial neointima formation by suppression of liver kinase B1 and AMPK activity.
Atherosclerosis 2012;222(2):417-25.
2012: H Ralph Schumacher; Yuhwen Soo; Neil Stahl; John S Sundy; Robert Terkeltaub; Steven P Weinstein; George D Yancopoulos; Shirletta King-Davis; Howard R Knapp; Scott J Mellis; Allen R Radin
Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: results of a phase II randomized, double-blind, placebo-controlled trial.
Arthritis and rheumatism 2012;64(3):876-84.
2012: K Jagadeesha Dammanahalli; Stephanie Stevens; Robert Terkeltaub
Vanin-1 pantetheinase drives smooth muscle cell activation in post-arterial injury neointimal hyperplasia.
PloS one 2012;7(6):e39106.
2011: Yvonne Nitschke; Robert Terkeltaub; Gabriele Weissen-Plenz; Frank Rutsch
Npp1 promotes atherosclerosis in ApoE knockout mice.
Journal of cellular and molecular medicine 2011;15(11):2273-83.
2011: Frank Rutsch; Yvonne Nitschke; Robert Terkeltaub
Genetics in arterial calcification: pieces of a puzzle and cogs in a wheel.
Circulation research 2011;109(5):578-92.
2011: Robert Terkeltaub; Bing Yang; Martin Lotz; Ru Liu-Bryan
Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α.
Arthritis and rheumatism 2011;63(7):1928-37.
2011: Dinesh Khanna; Puja P Khanna; Susan J Lee; Andrew J Sarkin; Marian M Shieh; Jasvinder A Singh; Robert Terkeltaub; Arthur F Kavanaugh; Jan D Hirsch
Minimally important differences of the gout impact scale in a randomized controlled trial.
Rheumatology (Oxford, England) 2011;50(7):1331-6.
2011: Tuhina Neogi; Robert Terkeltaub; R Curtis Ellison; Steven Hunt; Yuqing Zhang
Serum urate is not associated with coronary artery calcification: the NHLBI Family Heart Study.
The Journal of rheumatology 2011;38(1):111-7.
2010: Andrew J Sarkin; Ashley E Levack; Marian M Shieh; Arthur F Kavanaugh; Dinesh Khanna; Jasvinder A Singh; Robert Terkeltaub; Susan J Lee; Jan D Hirsch
Predictors of doctor-rated and patient-rated gout severity: gout impact scales improve assessment.
Journal of evaluation in clinical practice 2010;16(6):1244-7.
2010: Martin K Lotz; Shuhei Otsuki; Shawn P Grogan; Robert Sah; Robert Terkeltaub; Darryl D D'Lima
Cartilage cell clusters.
Arthritis and rheumatism 2010;62(8):2206-18.
2010: Ru Liu-Bryan; Robert Terkeltaub
Chondrocyte innate immune myeloid differentiation factor 88-dependent signaling drives procatabolic effects of the endogenous Toll-like receptor 2/Toll-like receptor 4 ligands low molecular weight hyaluronan and high mobility group box chromosomal protein 1 in mice.
Arthritis and rheumatism 2010;62(7):2004-12.
2010: Matthew Husa; Ru Liu-Bryan; Robert Terkeltaub
Shifting HIFs in osteoarthritis.
Nature medicine 2010;16(6):641-4.
2010: Robert Terkeltaub
Update on gout: new therapeutic strategies and options.
Nature reviews. Rheumatology 2010;6(1):30-8.
2010: Monika D Polewski; Kristen A Johnson; Melissa Foster; José Luis Millán; Robert Terkeltaub
Inorganic pyrophosphatase induces type I collagen in osteoblasts.
Bone 2010;46(1):81-90.
2009: Robert Terkeltaub; J S Sundy; H R Schumacher; F Murphy; S Bookbinder; S Biedermann; R Wu; S Mellis; A Radin
The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study.
Annals of the rheumatic diseases 2009;68(10):1613-7.
2009: Robert Terkeltaub; David Zelman; John Scavulli; Fernando Perez-Ruiz; Frédéric Lioté
Gout Study Group: update on hyperuricemia and gout.
Joint, bone, spine : revue du rhumatisme 2009;76(4):444-6.
2009: Susan J Lee; Jan D Hirsch; Robert Terkeltaub; Dinesh Khanna; Jasvinder A Singh; Andrew J Sarkin; Arthur Kavanaugh
Perceptions of disease and health-related quality of life among patients with gout.
Rheumatology (Oxford, England) 2009;48(5):582-6.
2009: Denise L Cecil; C Thomas G Appleton; Monika D Polewski; John S Mort; Ann Marie Schmidt; Alison Bendele; Frank Beier; Robert Terkeltaub
The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):5024-31.
2009: Jeannie Chao; Robert Terkeltaub
A critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in gout.
Current rheumatology reports 2009;11(2):135-40.
2009: Tuhina Neogi; R Curtis Ellison; Steven C Hunt; Robert Terkeltaub; JIMMY MOLYNEUX; Yuqing Zhang
Serum uric acid is associated with carotid plaques: the National Heart, Lung, and Blood Institute Family Heart Study.
The Journal of rheumatology 2009;36(2):378-84.
2009: Robert Terkeltaub
Gout. Novel therapies for treatment of gout and hyperuricemia.
Arthritis research & therapy 2009;11(4):236.
2008: Frank Rutsch; Petra Böyer; Yvonne Nitschke; Nico Ruf; Bettina Lorenz-Depierieux; Tanja Wittkampf; Gabriele Weissen-Plenz; Rudolf-Josef Fischer; Zulf Mughal; John W Gregory; Justin H Davies; Chantal Loirat; Tim M Strom; Dirk Schnabel; Peter Nürnberg; Robert Terkeltaub
Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy.
Circulation. Cardiovascular genetics 2008;1(2):133-40.
2008: Robert Terkeltaub
Macrophage glucocorticoid receptors join the intercellular dialogue in atherosclerotic lesion calcification.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(12):2096-8.
2008: Jan D Hirsch; Susan J Lee; Robert Terkeltaub; Dinesh Khanna; Jasvinder Singh; Andrew J Sarkin; Jodi Harvey; Arthur Kavanaugh
Evaluation of an instrument assessing influence of Gout on health-related quality of life.
The Journal of rheumatology 2008;35(12):2406-14.
2008: Denise L Cecil; Robert Terkeltaub
Transamidation by transglutaminase 2 transforms S100A11 calgranulin into a procatabolic cytokine for chondrocytes.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(12):8378-85.
2008: José Luis Millán; Sonoko Narisawa; Isabelle Lemire; Thomas P Loisel; Guy Boileau; Pierre Leonard; Svetlana Gramatikova; Robert Terkeltaub; Nancy Pleshko Camacho; Marc McKee; Philippe Crine; Michael P Whyte
Enzyme replacement therapy for murine hypophosphatasia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008;23(6):777-87.
2007: Robert Terkeltaub
Learning how and when to employ uricase as bridge therapy in refractory gout.
The Journal of rheumatology 2007;34(10):1955-8.
2007: Tertius A Hough; Monika Polewski; Kristen Johnson; Michael Cheeseman; Patrick M Nolan; Lucie Vizor; Sohaila Rastan; Alan Boyde; Kenneth Pritzker; A Jackie Hunter; Elizabeth M C Fisher; Robert Terkeltaub; Steve D M Brown
Novel mouse model of autosomal semidominant adult hypophosphatasia has a splice site mutation in the tissue nonspecific alkaline phosphatase gene Akp2.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(9):1397-407.
2007: Stephanie Hennigan; Robert Terkeltaub
Last call for alcohol in gout?
Current rheumatology reports 2007;9(3):229-30.
2007: Pavel Strnad; Masaru Harada; Matthew Siegel; Robert Terkeltaub; Robert M Graham; Chaitan Khosla; Bishr Omary
Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement.
Gastroenterology 2007;132(4):1515-26.
2006: Yuqing Zhang; Robert Terkeltaub; Michael Nevitt; Ling Xu; Tuhina Neogi; Piran Aliabadi; Jingbo Niu; JIMMY MOLYNEUX
Lower prevalence of chondrocalcinosis in Chinese subjects in Beijing than in white subjects in the United States: the Beijing Osteoarthritis Study.
Arthritis and rheumatism 2006;54(11):3508-12.
2006: Peter Scott; Hong Ma; Suganya Viriyakosol; Robert Terkeltaub; Ru Liu-Bryan
Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6370-8.
2006: David M Rose; Anya D Sydlaske; Amir Agha-Babakhani; Kristen Johnson; Robert Terkeltaub
Transglutaminase 2 limits murine peritoneal acute gout-like inflammation by regulating macrophage clearance of apoptotic neutrophils.
Arthritis and rheumatism 2006;54(10):3363-71.
2006: Dympna Harmey; Kristen A Johnson; Jonathan Zelken; Nancy P Camacho; Marc F Hoylaerts; Masaki Noda; Robert Terkeltaub; José Luis Millán
Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(9):1377-86.
2006: Robert Terkeltaub
Physiologic and pathologic functions of the NPP nucleotide pyrophosphatase/phosphodiesterase family focusing on NPP1 in calcification.
Purinergic signalling 2006;2(2):371-7.
2006: Susan J Lee; Robert Terkeltaub
New developments in clinically relevant mechanisms and treatment of hyperuricemia.
Current rheumatology reports 2006;8(3):224-30.
2006: Tuhina Neogi; Michael Nevitt; Jingbo Niu; Michael P LaValley; David J Hunter; Robert Terkeltaub; L Carbone; Hepei Chen; T Harris; Kent Kwoh; Ali Guermazi; JIMMY MOLYNEUX
Lack of association between chondrocalcinosis and increased risk of cartilage loss in knees with osteoarthritis: results of two prospective longitudinal magnetic resonance imaging studies.
Arthritis and rheumatism 2006;54(6):1822-8.
2006: Tuhina Neogi; Sarah L Booth; Yu Qing Zhang; Paul F Jacques; Robert Terkeltaub; Piran Aliabadi; JIMMY MOLYNEUX
Low vitamin K status is associated with osteoarthritis in the hand and knee.
Arthritis and rheumatism 2006;54(4):1255-61.
2006: William A Boisvert; David M Rose; Kristen A Johnson; Maria E Fuentes; sergio lira; Linda K Curtiss; Robert Terkeltaub
Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression.
The American journal of pathology 2006;168(4):1385-95.
2006: Susan J Lee; Robert Terkeltaub; Arthur Kavanaugh
Recent developments in diet and gout.
Current opinion in rheumatology 2006;18(2):193-8.
2006: William A Boisvert; David M Rose; Agnès Boullier; Oswald Quehenberger; Anya D Sydlaske; K A Johnson; Linda K Curtiss; Robert Terkeltaub
Leukocyte transglutaminase 2 expression limits atherosclerotic lesion size.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(3):563-9.
2006: Robert Terkeltaub
Hyperuricemia treatment: is creatinine clearance a safer allopurinol dosing meter than plasma creatinine levels?
Nature clinical practice. Rheumatology 2006;2(2):68-9.
2006: Ru Liu-Bryan; Robert Terkeltaub
Evil humors take their toll as innate immunity makes gouty joints TREM-ble.
Arthritis and rheumatism 2006;54(2):383-6.
2006: Robert Terkeltaub
Gout in 2006: the perfect storm.
Bulletin of the NYU hospital for joint diseases 2006;64(1-2):82-6.
2006: Robert Terkeltaub; David A Bushinsky; Michael A Becker
Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics.
Arthritis research & therapy 2006;8 Suppl 1():S4.
2006: Bruce N Cronstein; Robert Terkeltaub
The inflammatory process of gout and its treatment.
Arthritis research & therapy 2006;8 Suppl 1():S3.
2005: Denise L Cecil; Kristen Johnson; John Rediske; Martin Lotz; Ann Marie Schmidt; Robert Terkeltaub
Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):8296-302.
2005: Ru Liu-Bryan; Peter Scott; Anya D Sydlaske; David M Rose; Robert Terkeltaub
Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation.
Arthritis and rheumatism 2005;52(9):2936-46.
2005: H Clarke Anderson; Dympna Harmey; Nancy P Camacho; Rama Garimella; Joseph B Sipe; Sarah Tague; Xiaohong Bi; Kristen Johnson; Robert Terkeltaub; José Luis Millán
Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice.
The American journal of pathology 2005;166(6):1711-20.
2005: Christopher W Wu; Robert Terkeltaub; Kenneth C Kalunian
Calcium-containing crystals and osteoarthritis: implications for the clinician.
Current rheumatology reports 2005;7(3):213-9.
2005: Christopher W Wu; Robert Terkeltaub
What do epidemiologic studies tell us about hyperuricemia and cardiovascular disease and death?
Current rheumatology reports 2005;7(3):211-2.
2005: Ru Liu-Bryan; Kenneth Pritzker; Gary S Firestein; Robert Terkeltaub
TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):5016-23.
2005: Kristen A Johnson; Robert Terkeltaub
External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification.
The Journal of biological chemistry 2005;280(15):15004-12.
2005: Yun Zhang; Kristen Johnson; R Graham G Russell; B Paul Wordsworth; Andrew Carr; Robert Terkeltaub; Matthew A Brown
Association of sporadic chondrocalcinosis with a -4-basepair G-to-A transition in the 5'-untranslated region of ANKH that promotes enhanced expression of ANKH protein and excess generation of extracellular inorganic pyrophosphate.
Arthritis and rheumatism 2005;52(4):1110-7.
2005: Kristen Johnson; Monika Polewski; Deborah van Etten; Robert Terkeltaub
Chondrogenesis mediated by PPi depletion promotes spontaneous aortic calcification in NPP1-/- mice.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(4):686-91.
2005: Frank Rutsch; Robert Terkeltaub
Deficiencies of physiologic calcification inhibitors and low-grade inflammation in arterial calcification: lessons for cartilage calcification.
Joint, bone, spine : revue du rhumatisme 2005;72(2):110-8.
2005: Hengjiang Dong; Betty A Maddux; Jennifer Altomonte; Marcia Meseck; Domenico Accili; Robert Terkeltaub; Kristen Johnson; Jack F Youngren; Ira D Goldfine
Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance.
Diabetes 2005;54(2):367-72.
2005: Denise L Cecil; David M Rose; Robert Terkeltaub; Ru Liu-Bryan
Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes.
Arthritis and rheumatism 2005;52(1):144-54.
2005: Nico Ruf; Birgit Uhlenberg; Robert Terkeltaub; Peter Nürnberg; Frank Rutsch
The mutational spectrum of ENPP1 as arising after the analysis of 23 unrelated patients with generalized arterial calcification of infancy (GACI).
Human mutation 2005;25(1):98.
2005: Kristen Johnson; Robert Terkeltaub
Inorganic pyrophosphate (PPI) in pathologic calcification of articular cartilage.
Frontiers in bioscience : a journal and virtual library 2005;10():988-97.
2004: Nicole L Tramontini; Colleen Huber; Ru Liu-Bryan; Robert Terkeltaub; Kenneth S Kilgore
Central role of complement membrane attack complex in monosodium urate crystal-induced neutrophilic rabbit knee synovitis.
Arthritis and rheumatism 2004;50(8):2633-9.
2004: Jeffry D Bieber; Robert Terkeltaub
Gout: on the brink of novel therapeutic options for an ancient disease.
Arthritis and rheumatism 2004;50(8):2400-14.
2004: Jeffrey Bieber; Robert Terkeltaub
The role of hypertension in cyclosporine-induced hyperuricemia.
Current rheumatology reports 2004;6(3):215-6.
2004: Sucheta M Vaingankar; Thomas A Fitzpatrick; Kristen Johnson; James W Goding; Michèle Maurice; Robert Terkeltaub
Subcellular targeting and function of osteoblast nucleotide pyrophosphatase phosphodiesterase 1.
American journal of physiology. Cell physiology 2004;286(5):C1177-87.
2004: Kristen Johnson; Camilla I Svensson; Deborah Van Etten; Soumitra S Ghosh; Anne N Murphy; Henry C Powell; Robert Terkeltaub
Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs.
Arthritis and rheumatism 2004;50(4):1216-25.
2004: Dympna Harmey; Lovisa Hessle; Sonoko Narisawa; Kristen A Johnson; Robert Terkeltaub; José Luis Millán
Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders.
The American journal of pathology 2004;164(4):1199-209.
2004: Ru Liu; Frédéric Lioté; David M Rose; Denise Merz; Robert Terkeltaub
Proline-rich tyrosine kinase 2 and Src kinase signaling transduce monosodium urate crystal-induced nitric oxide production and matrix metalloproteinase 3 expression in chondrocytes.
Arthritis and rheumatism 2004;50(1):247-58.
2003: Ingrid Schraufstatter; Khanh Trieu; Ming Zhao; David M Rose; Robert Terkeltaub; Meike Burger
IL-8-mediated cell migration in endothelial cells depends on cathepsin B activity and transactivation of the epidermal growth factor receptor.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6714-22.
2003: Robert Terkeltaub
Questions & answers. What's the difference between gout and pseudogout?
Health news (Waltham, Mass.) 2003;9(12):16.
2003: Robert Terkeltaub
Clinical practice. Gout.
The New England journal of medicine 2003;349(17):1647-55.
2003: Denise Merz; Ru Liu; Kristen Johnson; Robert Terkeltaub
IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4406-15.
2003: Frank Rutsch; Nico Ruf; Sucheta M Vaingankar; Mohammad R Toliat; Anita Suk; Wolfgang Höhne; Galen Schauer; Mandy Lehmann; Tony Roscioli; Dirk Schnabel; Jörg T Epplen; Alex Knisely; andrea superti-furga; James McGill; Marco Filippone; Alan R Sinaiko; Hillary Vallance; Bernd Hinrichs; Wendy Smith; Merry Ferre; Robert Terkeltaub; Peter Nürnberg
Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification.
Nature genetics 2003;34(4):379-81.
2003: Kristen Johnson; James W Goding; Deborah van Etten; Adnan Sali; Shou-Ih Hu; David Farley; Hollis Krug; Lovisa Hessle; José Luis Millán; Robert Terkeltaub
Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(6):994-1004.
2003: Salih Pay; Robert Terkeltaub
Calcium pyrophosphate dihydrate and hydroxyapatite crystal deposition in the joint: new developments relevant to the clinician.
Current rheumatology reports 2003;5(3):235-43.
2003: Kristen A Johnson; Deborah van Etten; Nisha Nanda; Robert M Graham; Robert Terkeltaub
Distinct transglutaminase 2-independent and transglutaminase 2-dependent pathways mediate articular chondrocyte hypertrophy.
The Journal of biological chemistry 2003;278(21):18824-32.
2003: Kristen Johnson; David Farley; Shou-Ih Hu; Robert Terkeltaub
One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist.
Arthritis and rheumatism 2003;48(5):1302-14.
2003: Frank Rutsch; Robert Terkeltaub
Parallels between arterial and cartilage calcification: what understanding artery calcification can teach us about chondrocalcinosis.
Current opinion in rheumatology 2003;15(3):302-10.
2002: Manjiri M Bakre; Yuhong Zhu; Hong Yin; Douglas Burton; Robert Terkeltaub; Leonard J Deftos; Judith A Varner
Parathyroid hormone-related peptide is a naturally occurring, protein kinase A-dependent angiogenesis inhibitor.
Nature medicine 2002;8(9):995-1003.
2002: Lovisa Hessle; Kristen A Johnson; H Clarke Anderson; Sonoko Narisawa; Adnan Sali; James W Goding; Robert Terkeltaub; José Luis Millan
Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9445-9.
2002: Robert Terkeltaub
Pseudogout, hypomagnesemia, and liver transplantation.
Current rheumatology reports 2002;4(3):243-4.
2002: Robert Terkeltaub
What does cartilage calcification tell us about osteoarthritis?
The Journal of rheumatology 2002;29(3):411-5.
2002: Robert Terkeltaub; Kristen Johnson; Anne Murphy; Soumitra Ghosh
Invited review: the mitochondrion in osteoarthritis.
Mitochondrion 2002;1(4):301-19.
2001: K Johnson; Kenneth Pritzker; James W Goding; Robert Terkeltaub
The nucleoside triphosphate pyrophosphohydrolase isozyme PC-1 directly promotes cartilage calcification through chondrocyte apoptosis and increased calcium precipitation by mineralizing vesicles.
The Journal of rheumatology 2001;28(12):2681-91.
2001: K Johnson; S Hashimoto; M Lotz; Kenneth Pritzker; James W Goding; Robert Terkeltaub
Up-regulated expression of the phosphodiesterase nucleotide pyrophosphatase family member PC-1 is a marker and pathogenic factor for knee meniscal cartilage matrix calcification.
Arthritis and rheumatism 2001;44(5):1071-81.
2001: Randal Goomer; Leonard J Deftos; Robert Terkeltaub; Thira Maris; M C Lee; Frederick L Harwood; David Amiel
High-efficiency non-viral transfection of primary chondrocytes and perichondrial cells for ex-vivo gene therapy to repair articular cartilage defects.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(3):248-56.
2001: Frank Rutsch; Sucheta M Vaingankar; Kristen Johnson; Ira D Goldfine; Betty A Maddux; P Schauerte; Hermann Kalhoff; K Sano; William A Boisvert; andrea superti-furga; Robert Terkeltaub
PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification.
The American journal of pathology 2001;158(2):543-54.
2000: Randal Goomer; K A Johnson; Douglas Burton; David Amiel; Thira Maris; A Gurjal; L J Deftost; Robert Terkeltaub
The tetrabasic KKKK(147-150) motif determines intracrine regulatory effects of PthrP 1-173 on chondrocyte PPi metabolism and matrix synthesis.
Endocrinology 2000;141(12):4613-22.
2000: Kristen A Johnson; Lovisa Hessle; Sucheta M Vaingankar; Charlotte Wennberg; S Mauro; Sonoko Narisawa; James W Goding; K Sano; José Luis Millan; Robert Terkeltaub
Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;279(4):R1365-77.
2000: Kristen Johnson; A Jung; A Murphy; Alexander Andreyev; J Dykens; Robert Terkeltaub
Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization.
Arthritis and rheumatism 2000;43(7):1560-70.
2000: R Liu; M O'Connell; Kristen Johnson; Kenneth Pritzker; Nigel Mackman; Robert Terkeltaub
Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells.
Arthritis and rheumatism 2000;43(5):1145-55.
2000: William A Boisvert; Linda K Curtiss; Robert Terkeltaub
Interleukin-8 and its receptor CXCR2 in atherosclerosis.
Immunologic research 2000;21(2-3):129-37.
1999: Kristen Johnson; Sucheta M Vaingankar; Y Chen; A Moffa; M B Goldring; K Sano; P Jin-Hua; Adnan Sali; James W Goding; Robert Terkeltaub
Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes.
Arthritis and rheumatism 1999;42(9):1986-97.
1999: K Johnson; A Moffa; Y Chen; Kenneth Pritzker; James W Goding; Robert Terkeltaub
Matrix vesicle plasma cell membrane glycoprotein-1 regulates mineralization by murine osteoblastic MC3T3 cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(6):883-92.
1998: Robert Terkeltaub; Martin Lotz; K Johnson; D Deng; S Hashimoto; M B Goldring; D Burton; L J Deftos
Parathyroid hormone-related proteins is abundant in osteoarthritic cartilage, and the parathyroid hormone-related protein 1-173 isoform is selectively induced by transforming growth factor beta in articular chondrocytes and suppresses generation of extracellular inorganic pyrophosphate.
Arthritis and rheumatism 1998;41(12):2152-64.
1998: Robert Terkeltaub; William A Boisvert; Linda K Curtiss
Chemokines and atherosclerosis.
Current opinion in lipidology 1998;9(5):397-405.
1998: Robert Terkeltaub; K Johnson; D Rohnow; Randal Goomer; D Burton; Leonard J Deftos
Bone morphogenetic proteins and bFGF exert opposing regulatory effects on PTHrP expression and inorganic pyrophosphate elaboration in immortalized murine endochondral hypertrophic chondrocytes (MCT cells).
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998;13(6):931-41.
1998: Robert Terkeltaub; S Baird; P Sears; R Santiago; William A Boisvert
The murine homolog of the interleukin-8 receptor CXCR-2 is essential for the occurrence of neutrophilic inflammation in the air pouch model of acute urate crystal-induced gouty synovitis.
Arthritis and rheumatism 1998;41(5):900-9.
1998: Sanshiro Hashimoto; R L Ochs; F Rosen; Jacqueline Quach; G McCabe; J Solan; J E Seegmiller; Robert Terkeltaub; Martin Lotz
Chondrocyte-derived apoptotic bodies and calcification of articular cartilage.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):3094-9.
1998: James W Goding; Robert Terkeltaub; Michèle Maurice; P Deterre; Adnan Sali; S I Belli
Ecto-phosphodiesterase/pyrophosphatase of lymphocytes and non-lymphoid cells: structure and function of the PC-1 family.
Immunological reviews 1998;161():11-26.
1998: William A Boisvert; R Santiago; Linda K Curtiss; Robert Terkeltaub
A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.
The Journal of clinical investigation 1998;101(2):353-63.
1997: F Rosen; G McCabe; Jacqueline Quach; J Solan; Robert Terkeltaub; J E Seegmiller; Martin Lotz
Differential effects of aging on human chondrocyte responses to transforming growth factor beta: increased pyrophosphate production and decreased cell proliferation.
Arthritis and rheumatism 1997;40(7):1275-81.
1995: Martin Lotz; F Rosen; G McCabe; Jacqueline Quach; F Blanco; J Dudler; J Solan; James W Goding; J E Seegmiller; Robert Terkeltaub
Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10364-8.
1994: R Huang; M Rosenbach; R Vaughn; D Provvedini; N Rebbe; S Hickman; James W Goding; Robert Terkeltaub
Expression of the murine plasma cell nucleotide pyrophosphohydrolase PC-1 is shared by human liver, bone, and cartilage cells. Regulation of PC-1 expression in osteosarcoma cells by transforming growth factor-beta.
The Journal of clinical investigation 1994;94(2):560-7.
1994: Robert Terkeltaub; J Solan; M Barry; D Santoro; G M Bokoch
Role of the mevalonate pathway of isoprenoid synthesis in IL-8 generation by activated monocytic cells.
Journal of leukocyte biology 1994;55(6):749-55.
1994: Robert Terkeltaub; M Rosenbach; F Fong; James W Goding
Causal link between nucleotide pyrophosphohydrolase overactivity and increased intracellular inorganic pyrophosphate generation demonstrated by transfection of cultured fibroblasts and osteoblasts with plasma cell membrane glycoprotein-1. Relevance to calcium pyrophosphate dihydrate deposition disease.
Arthritis and rheumatism 1994;37(6):934-41.
1994: K Brand; Carole L Banka; Nigel Mackman; Robert Terkeltaub; S T Fan; Linda K Curtiss
Oxidized LDL enhances lipopolysaccharide-induced tissue factor expression in human adherent monocytes.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(5):790-7.
1994: Robert Terkeltaub; Carole L Banka; J Solan; D Santoro; K Brand; Linda K Curtiss
Oxidized LDL induces monocytic cell expression of interleukin-8, a chemokine with T-lymphocyte chemotactic activity.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(1):47-53.
1992: P M Villiger; Robert Terkeltaub; Martin Lotz
Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid.
The Journal of clinical investigation 1992;90(2):488-96.
1992: P M Villiger; Robert Terkeltaub; Martin Lotz
Production of monocyte chemoattractant protein-1 by inflamed synovial tissue and cultured synoviocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(2):722-7.
1992: Martin Lotz; Robert Terkeltaub; P M Villiger
Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(2):466-73.
1991: Robert Terkeltaub; C Zachariae; D Santoro; J Martin; P Peveri; K Matsushima
Monocyte-derived neutrophil chemotactic factor/interleukin-8 is a potential mediator of crystal-induced inflammation.
Arthritis and rheumatism 1991;34(7):894-903.
1991: Robert Terkeltaub; Cheryl A Dyer; J Martin; Linda K Curtiss
Apolipoprotein (apo) E inhibits the capacity of monosodium urate crystals to stimulate neutrophils. Characterization of intraarticular apo E and demonstration of apo E binding to urate crystals in vivo.
The Journal of clinical investigation 1991;87(1):20-6.