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Andrew Teschendorff

Research Profile

Disorders

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Gene Expression Profiling

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Oligonucleotide Array Sequence Analysis

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Tumor Cell Line

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Epigenomics

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Publications

TOP 3
Francesco Marabita; Sabrina Ruhrmann; Carl J Sundberg; Jesper Tegnér; Andrew E Teschendorff; Malin Almgren; Tomas J Ekström; Fredrik Fagerström-Billai; Maja Jagodic; Maléne E Lindholm; David Gomez-Cabrero
An evaluation of analysis pipelines for DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platform.
Andrew E Teschendorff; Thomas Bartlett; David Gomez-Cabrero; Matthias Lechner; Francesco Marabita; Jesper Tegner; Stephan Beck
A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data.
James West; Xiangdong Wang; Stephan Beck; Andrew E Teschendorff
An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways.

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All Publications

2013: Francesco Marabita; Sabrina Ruhrmann; Carl J Sundberg; Jesper Tegnér; Andrew E Teschendorff; Malin Almgren; Tomas J Ekström; Fredrik Fagerström-Billai; Maja Jagodic; Maléne E Lindholm; David Gomez-Cabrero
An evaluation of analysis pipelines for DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platform.
Epigenetics : official journal of the DNA Methylation Society 2013;8(3):333-46.
2013: Andrew E Teschendorff; Thomas Bartlett; David Gomez-Cabrero; Matthias Lechner; Francesco Marabita; Jesper Tegner; Stephan Beck
A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data.
Bioinformatics (Oxford, England) 2013;29(2):189-96.
2013: James West; Xiangdong Wang; Stephan Beck; Andrew E Teschendorff
An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways.
Scientific reports 2013;3():1630.
2013: Martin Widschwendter; Allison Jones; Andrew E Teschendorff
Epigenetics makes its mark on women-specific cancers--an opportunity to redefine oncological approaches?
Gynecologic oncology 2013;128(1):134-43.
2012: Robert Häsler; Vardhman K Rakyan; Liselotte Bäckdahl; Stephan Beck; Thomas A Down; Andrew Feber; Zhe Feng; Andre Franke; Stefan Schreiber; Martina E Spehlmann; Andrew E Teschendorff; Gareth A Wilson; Philip Rosenstiel
A functional methylome map of ulcerative colitis.
Genome research 2012;22(11):2130-7.
2012: Andrew E Teschendorff; Martin Widschwendter
Differential variability improves the identification of cancer risk markers in DNA methylation studies profiling precursor cancer lesions.
Bioinformatics (Oxford, England) 2012;28(11):1487-94.
2012: James West; Lucas Lacasa; Simone Severini; Andrew E Teschendorff
Approximate entropy of network parameters.
Physical review. E, Statistical, nonlinear, and soft matter physics 2012;85(4 Pt 2):046111.
2012: Joanna Zhuang; Michal Zikan; David Cibula; Heidi Fiegl; Ian J Jacobs; Allison Jones; Henry C Kitchener; Shih-Han Lee; Esther Ng; Helga B Salvesen; Alexandra Sargent; Andrew E Teschendorff; Martin Widschwendter
The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer.
PLoS genetics 2012;8(2):e1002517.
2012: Caryn S Ross-Innes; Rory Stark; Andrew E Teschendorff; H Raza Ali; Simak Ali; Gordon D Brown; Carlos Caldas; Suet-Feung Chin; Mark J Dunning; Ian O Ellis; Ondrej Gojis; Andrew R Green; Kelly A Holmes; Carlo Palmieri; Jason S Carroll
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer.
Nature 2012;481(7381):389-93.
2012: James West; Ginestra Bianconi; Simone Severini; Andrew E Teschendorff
Differential network entropy reveals cancer system hallmarks.
Scientific reports 2012;2():802.
2012: Christina Thirlwell; Andrew Feber; Matthias Lechner; Andrew E Teschendorff; Stephan Beck
Comments on: Interpretation of genome-wide infinium methylation data from ligated DNA in formalin-fixed paraffin-embedded paired tumor and normal tissue.
BMC research notes 2012;5():631.
2012: Joanna Zhuang; Martin Widschwendter; Andrew E Teschendorff
A comparison of feature selection and classification methods in DNA methylation studies using the Illumina Infinium platform.
BMC bioinformatics 2012;13():59.
2012: Andrew E Teschendorff; Joanna J Zhuang; Heidi Fiegl; Allison Jones; Henry C Kitchener; Alexandra Sargent; Martin Widschwendter
Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation.
Genome medicine 2012;4(3):24.
2011: Andrew E Teschendorff; Joanna Zhuang; Martin Widschwendter
Independent surrogate variable analysis to deconvolve confounding factors in large-scale microarray profiling studies.
Bioinformatics (Oxford, England) 2011;27(11):1496-505.
2011: Andrew Feber; Gareth A Wilson; Lu Zhang; Nadège Presneau; Bernadine Idowu; Thomas A Down; Vardhman K Rakyan; Luke Noon; Alison C Lloyd; Elia Stupka; Vassia Schiza; Andrew E Teschendorff; Gary P Schroth; Adrienne M Flanagan; Stephan Beck
Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors.
Genome research 2011;21(4):515-24.
2011: Yan Jiao; Annette F Jones; Katherine Lawler; Tony Ng; Gargi S Patel; Arnie Purushotham; Anita Grigoriadis; Andrew Tutt; Andrew E Teschendorff
DART: Denoising Algorithm based on Relevance network Topology improves molecular pathway activity inference.
BMC bioinformatics 2011;12():403.
2010: Christina Thirlwell; Marianne Eymard; Andrew Feber; Andrew E Teschendorff; Kerra Pearce; Matthias Lechner; Martin Widschwendter; Stephan Beck
Genome-wide DNA methylation analysis of archival formalin-fixed paraffin-embedded tissue using the Illumina Infinium HumanMethylation27 BeadChip.
Methods (San Diego, Calif.) 2010;52(3):248-54.
2010: Hege G Russnes; Hans Kristian Moen Vollan; Ole Christian Lingjaerde; Alexander Krasnitz; Pär Lundin; Bjørn Naume; Therese Sørlie; Elin Borgen; Inga H Rye; Anita Langerød; Suet-Feung Chin; Andrew E Teschendorff; Philip J Stephens; Susanne Månér; Ellen Schlichting; Lars O Baumbusch; Rolf Kåresen; Michael P Stratton; Michael Wigler; Carlos Caldas; Anders Zetterberg; James Hicks; Anne-Lise Børresen-Dale
Genomic architecture characterizes tumor progression paths and fate in breast cancer patients.
Science translational medicine 2010;2(38):38ra47.
2010: E M Azzato; A J X Lee; Andrew E Teschendorff; B A J Ponder; Paul Pharoah; Carlos Caldas; A T Maia
Common germ-line polymorphism of C1QA and breast cancer survival.
British journal of cancer 2010;102(8):1294-9.
2010: Andrew E Teschendorff; Usha Menon; Aleksandra Gentry-Maharaj; Susan J Ramus; Daniel J Weisenberger; Hui Shen; Mihaela Campan; Houtan Noushmehr; Christopher G Bell; A Peter Maxwell; David A Savage; Elisabeth Mueller-Holzner; Christian Marth; Gabrijela Kocjan; Simon A Gayther; Allison Jones; Stephan Beck; Wolfgang Wagner; Peter W Laird; Ian J Jacobs; Martin Widschwendter
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer.
Genome research 2010;20(4):440-6.
2010: Andrew E Teschendorff; Yan Jiao; Carlos Caldas
Prognostic gene network modules in breast cancer hold promise.
Breast cancer research : BCR 2010;12(6):317.
2010: Christopher G Bell; Sarah Finer; Cecilia M Lindgren; Gareth A Wilson; Vardhman K Rakyan; Andrew E Teschendorff; Pelin Akan; Elia Stupka; Thomas A Down; Inga Prokopenko; Ian M Morison; Jonathan Mill; Ruth Pidsley; Panos Deloukas; Timothy M Frayling; Andrew T Hattersley; Mark I McCarthy; Stephan Beck; Graham A Hitman
Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.
PloS one 2010;5(11):e14040.
2010: Andrew E Teschendorff; Sergio Gomez; Alex Arenas; Dorraya El-Ashry; Marcus Schmidt; Mathias Gehrmann; Carlos Caldas
Improved prognostic classification of breast cancer defined by antagonistic activation patterns of immune response pathway modules.
BMC cancer 2010;10():604.
2010: Christopher G Bell; Andrew E Teschendorff; Vardhman K Rakyan; Alexander P Maxwell; Stephan Beck; David A Savage
Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus.
BMC medical genomics 2010;3():33.
2010: Andrew E Teschendorff; Simone Severini
Increased entropy of signal transduction in the cancer metastasis phenotype.
BMC systems biology 2010;4():104.
2009: Miriam S Udler; Elizabeth M Azzato; Catherine S Healey; Shahana Ahmed; Karen A Pooley; David Greenberg; Mitul Shah; Andrew E Teschendorff; Carlos Caldas; Alison M Dunning; Elaine A Ostrander; Neil E Caporaso; Douglas Easton; Paul D P Pharoah
Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer.
International journal of cancer. Journal international du cancer 2009;125(11):2687-96.
2009: Sohrab P Shah; Rene Warren; Jaswinder Khattra; Leah Prentice; Trevor Pugh; Angela Burleigh; Allen Delaney; Karen Gelmon; Ryan Guliany; Janine Senz; Christian Steidl; Robert A Holt; Steven Jones; Mark Sun; Gillian Leung; Richard Moore; Tesa Severson; Greg A Taylor; Andrew E Teschendorff; Kane Tse; Gulisa Turashvili; Richard Varhol; René L Warren; Peter Watson; Yongjun Zhao; Carlos Caldas; David Huntsman; Martin Hirst; Marco A Marra; Samuel Aparicio
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution.
Nature 2009;461(7265):809-13.
2009: Andrew E Teschendorff; Usha Menon; Aleksandra Gentry-Maharaj; Susan J Ramus; Simon A Gayther; Sophia Apostolidou; Allison Jones; Matthias Lechner; Stephan Beck; Ian J Jacobs; Martin Widschwendter
An epigenetic signature in peripheral blood predicts active ovarian cancer.
PloS one 2009;4(12):e8274.
2009: Andrew E Teschendorff; Carlos Caldas
The breast cancer somatic 'muta-ome': tackling the complexity.
Breast cancer research : BCR 2009;11(2):301.
2008: Lindsay A Brown; Jeremy Hoog; Suet-Feung Chin; Yu Tao; Abd Alnaser Zayed; Koei Chin; Andrew E Teschendorff; John F Quackenbush; John C Marioni; Samuel Leung; Charles M Perou; Torsten O Neilsen; Matthew Ellis; Joe Gray; Philip S Bernard; David G Huntsman; Carlos Caldas
ESR1 gene amplification in breast cancer: a common phenomenon?
Nature genetics 2008;40(7):806-7; author reply 810-2.
2008: Kerstin B Meyer; Ana-Teresa Maia; Martin O'Reilly; Andrew E Teschendorff; Suet-Feung Chin; Carlos Caldas; Bruce A J Ponder
Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer.
PLoS biology 2008;6(5):e108.
2008: Fabien Reyal; Martin H van Vliet; Nicola J Armstrong; Hugo M Horlings; Karin E de Visser; Marleen Kok; Andrew E Teschendorff; Stella Mook; Laura J van 't Veer; Carlos Caldas; Remy J Salmon; Marc J van de Vijver; Lodewyk F A Wessels
A comprehensive analysis of prognostic signatures reveals the high predictive capacity of the proliferation, immune response and RNA splicing modules in breast cancer.
Breast cancer research : BCR 2008;10(6):R93.
2008: Andrew E Teschendorff; Carlos Caldas
A robust classifier of high predictive value to identify good prognosis patients in ER-negative breast cancer.
Breast cancer research : BCR 2008;10(4):R73.
2008: Elizabeth M Azzato; Kristy E Driver; Fabienne LESUEUR; Mitul Shah; David Greenberg; Douglas F Easton; Andrew E Teschendorff; Carlos Caldas; Neil E Caporaso; Paul D P Pharoah
Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort.
Breast cancer research : BCR 2008;10(3):R47.
2007: Andrew E Teschendorff; Michel Journée; Pierre A Absil; Rodolphe Sepulchre; Carlos Caldas
Elucidating the altered transcriptional programs in breast cancer using independent component analysis.
PLoS computational biology 2007;3(8):e161.
2007: Ali Naderi; Andrew E Teschendorff; Juergen Beigel; Massimiliano Cariati; Ian O Ellis; James D Brenton; Carlos Caldas
BEX2 is overexpressed in a subset of primary breast cancers and mediates nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines.
Cancer research 2007;67(14):6725-36.
2007: Anna L Paterson; Jessica C M Pole; Katherine A Blood; Maria J Garcia; Susanna L Cooke; Andrew E Teschendorff; Yanzhong Wang; Suet-Feung Chin; Bauke Ylstra; Carlos Caldas; Paul A W Edwards
Co-amplification of 8p12 and 11q13 in breast cancers is not the result of a single genomic event.
Genes, chromosomes & cancer 2007;46(5):427-39.
2007: Suet-Feung Chin; Yanzhong Wang; Natalie P Thorne; Andrew E Teschendorff; Sarah Elizabeth Pinder; Maria Vias; Ali Naderi; Ian Roberts; Nuno Barbosa-Morais; Maria J Garcia; N Gopalakrishna Iyer; Tanja Kranjac; J F R Robertson; Samuel A J R Aparicio; Simon Tavaré; Ian O Ellis; James D Brenton; Carlos Caldas
Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers.
Oncogene 2007;26(13):1959-70.
2007: Ali Naderi; Andrew E Teschendorff; Nuno Barbosa-Morais; Sarah Elizabeth Pinder; Anthony R Green; D G Powe; J F R Robertson; Samuel A J R Aparicio; Ian O Ellis; James D Brenton; Carlos Caldas
A gene-expression signature to predict survival in breast cancer across independent data sets.
Oncogene 2007;26(10):1507-16.
2007: Suet-Feung Chin; Andrew E Teschendorff; John C Marioni; Yanzhong Wang; Nuno Barbosa-Morais; Natalie P Thorne; Jose L Costa; Sarah Elizabeth Pinder; Mark A van de Wiel; Andrew Green; Ian O Ellis; Peggy L Porter; Simon Tavaré; James D Brenton; Bauke Ylstra; Carlos Caldas
High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer.
Genome biology 2007;8(10):R215.
2007: Cherie Blenkiron; Leonard D Goldstein; Natalie P Thorne; Inmaculada Spiteri; Suet-Feung Chin; Mark Dunning; Nuno Barbosa-Morais; Andrew E Teschendorff; Andrew R Green; Ian O Ellis; Simon Tavaré; Carlos Caldas; Eric A Miska
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype.
Genome biology 2007;8(10):R214.
2007: Andrew E Teschendorff; Ahmad Miremadi; Sarah Elizabeth Pinder; Ian O Ellis; Carlos Caldas
An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer.
Genome biology 2007;8(8):R157.
2006: M Trent Herdman; Mark R Pett; Ian Roberts; William Alazawi; Andrew E Teschendorff; Xiao-Yin Zhang; Margaret A Stanley; Nicholas Coleman
Interferon-beta treatment of cervical keratinocytes naturally infected with human papillomavirus 16 episomes promotes rapid reduction in episome numbers and emergence of latent integrants.
Carcinogenesis 2006;27(11):2341-53.
2006: Andrew E Teschendorff; Ali Naderi; Nuno Barbosa-Morais; Carlos Caldas
PACK: Profile Analysis using Clustering and Kurtosis to find molecular classifiers in cancer.
Bioinformatics (Oxford, England) 2006;22(18):2269-75.
2006: Amber E Alsop; Andrew E Teschendorff; Paul A W Edwards
Distribution of breakpoints on chromosome 18 in breast, colorectal, and pancreatic carcinoma cell lines.
Cancer genetics and cytogenetics 2006;164(2):97-109.
2006: Andrew E Teschendorff; Ali Naderi; Nuno Barbosa-Morais; Sarah Elizabeth Pinder; Ian O Ellis; Samuel A J R Aparicio; James D Brenton; Carlos Caldas
A consensus prognostic gene expression classifier for ER positive breast cancer.
Genome biology 2006;7(10):R101.
2006: Hilal Ozdağ; Andrew E Teschendorff; Ahmed Ashour Ahmed; Sarah J Hyland; Cherie Blenkiron; Lynda Bobrow; Abhi Veerakumarasivam; Glyn J Burtt; Tatiana Subkhankulova; Mark J Arends; V Peter Collins; David Bowtell; Tony Kouzarides; James D Brenton; Carlos Caldas
Differential expression of selected histone modifier genes in human solid cancers.
BMC genomics 2006;7():90.
2005: Maria J Garcia; Jessica C M Pole; Suet-Feung Chin; Andrew E Teschendorff; Ali Naderi; Hilal Ozdag; Maria Vias; Tanja Kranjac; Tatiana Subkhankulova; Claire Paish; Ian O Ellis; James D Brenton; Paul A W Edwards; Carlos Caldas
A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes.
Oncogene 2005;24(33):5235-45.
2005: Andrew E Teschendorff; Yanzhong Wang; Nuno Barbosa-Morais; James D Brenton; Carlos Caldas
A variational Bayesian mixture modelling framework for cluster analysis of gene-expression data.
Bioinformatics (Oxford, England) 2005;21(13):3025-33.