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John Tesmer

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TOP 3
Mark R Nance; Rachel Sterne-Marr; Tohru Kozasa; Barry Kreutz; Valerie M Tesmer; John J G Tesmer
Structural and functional analysis of the regulator of g protein signaling 2-gαq complex.
Angeline M Lyon; georgios skiniotis; Cassandra A Boguth; Somnath Dutta; John J G Tesmer
Full-length Gα(q)-phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain.
Rachel Sterne-Marr; Alison I Baillargeon; Kevin R Michalski; John J G Tesmer
Expression, purification, and analysis of G-protein-coupled receptor kinases.

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All Publications

2013: Mark R Nance; Rachel Sterne-Marr; Tohru Kozasa; Barry Kreutz; Valerie M Tesmer; John J G Tesmer
Structural and functional analysis of the regulator of g protein signaling 2-gαq complex.
Structure (London, England : 1993) 2013;21(3):438-48.
2013: Angeline M Lyon; georgios skiniotis; Cassandra A Boguth; Somnath Dutta; John J G Tesmer
Full-length Gα(q)-phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain.
Nature structural & molecular biology 2013;20(3):355-62.
2013: Rachel Sterne-Marr; Alison I Baillargeon; Kevin R Michalski; John J G Tesmer
Expression, purification, and analysis of G-protein-coupled receptor kinases.
Methods in enzymology 2013;521():347-66.
2013: K T Homan; A Glukhova; John J G Tesmer
Regulation of G protein-coupled receptor kinases by phospholipids.
Current medicinal chemistry 2013;20(1):39-46.
2012: David M Thal; Emily K Wu; Jun Chen; Joseph Y Cheung; J Kurt Chuprun; Erhe Gao; Patricia M Hinkle; Kristoff T Homan; Z Maggie Huang; Walter J Koch; Larry A Sklar; Jianliang Song; John J G Tesmer
Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.
ACS chemical biology 2012;7(11):1830-9.
2012: Valerie M Tesmer; Sabine Lennarz; Günter Mayer; John J G Tesmer
Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer.
Structure (London, England : 1993) 2012;20(8):1300-9.
2012: John J G Tesmer; Mark R Nance; Puja Singh; Harie Lee
Structure of a monomeric variant of rhodopsin kinase at 2.5 Å resolution.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 6):622-5.
2012: Bruce S Edwards; Steven W Graves; Mark B Carter; Jun Chen; John J G Tesmer; David M Thal; Jingshu Zhu; Larry A Sklar
Cluster cytometry for high-capacity bioanalysis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2012;81(5):419-29.
2012: Tivadar Orban; Kristoff T Homan; Chih-Chin Huang; Beata Jastrzebska; John J G Tesmer; Krzysztof Palczewski
Substrate-induced changes in the dynamics of rhodopsin kinase (G protein-coupled receptor kinase 1).
Biochemistry 2012;51(16):3404-11.
2012: John J G Tesmer
A GAIN in understanding autoproteolytic G protein-coupled receptors and polycystic kidney disease proteins.
The EMBO journal 2012;31(6):1334-5.
2011: Diwahar Narasimhan; Joseph Nichols; John J G Tesmer; James H Woods; Jimmy Chan; Gregory Collins; Elin Edwald; Mei-Chuan Ko; Mark R Nance; Roger K Sunahara
Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Molecular pharmacology 2011;80(6):1056-65.
2011: Mohamed Aittaleb; Maurine E Linder; Akiyuki Nishimura; John J G Tesmer
Plasma membrane association of p63 Rho guanine nucleotide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cells.
The Journal of biological chemistry 2011;286(39):34448-56.
2011: Andrew P Boughton; Bei Ding; John J G Tesmer; Valerie M Tesmer; Pei Yang; Zhan Chen
Heterotrimeric G protein beta1gamma2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(37):E667-73.
2011: Angeline M Lyon; John K Northup; Krishna C Suddala; Shoaib Chowdhury; Vishan D Dhamsania; Joanne Gutierrez; Valerie M Tesmer; David M Thal; John J G Tesmer
An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation.
Nature structural & molecular biology 2011;18(9):999-1005.
2011: Chih-Chin Huang; Tivadar Orban; Beata Jastrzebska; Krzysztof Palczewski; John J G Tesmer
Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain.
Biochemistry 2011;50(11):1940-9.
2011: Chih-chin Huang; John J G Tesmer
Recognition in the face of diversity: interactions of heterotrimeric G proteins and G protein-coupled receptor (GPCR) kinases with activated GPCRs.
The Journal of biological chemistry 2011;286(10):7715-21.
2011: Timothy H Bayburt; Sergey A Vishnivetskiy; Mark A McLean; Takefumi Morizumi; Chih-Chin Huang; John J G Tesmer; Oliver P Ernst; Stephen G Sligar; Vsevolod V Gurevich
Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 binding.
The Journal of biological chemistry 2011;286(2):1420-8.
2010: Cassandra A Boguth; Puja Singh; Chih-chin Huang; John J G Tesmer
Molecular basis for activation of G protein-coupled receptor kinases.
The EMBO journal 2010;29(19):3249-59.
2010: Diwahar Narasimhan; Mark R Nance; Daquan Gao; Mei-Chuan Ko; Joanne Macdonald; Patricia Tamburi; Dan Yoon; Donald M Landry; James H Woods; Chang-Guo Zhan; John J G Tesmer; Roger K Sunahara
Structural analysis of thermostabilizing mutations of cocaine esterase.
Protein engineering, design & selection : PEDS 2010;23(7):537-47.
2010: Aruna Shankaranarayanan; Cassandra A Boguth; Susanne Lutz; Christiane Vettel; Franca Uhlemann; Mohamed Aittaleb; Thomas Wieland; John J G Tesmer
Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF.
Cellular signalling 2010;22(7):1114-23.
2010: John J G Tesmer
The quest to understand heterotrimeric G protein signaling.
Nature structural & molecular biology 2010;17(6):650-2.
2010: Remy L Brim; Mark R Nance; Daniel W Youngstrom; Diwahar Narasimhan; Chang-Guo Zhan; John J G Tesmer; Roger K Sunahara; James H Woods
A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse.
Molecular pharmacology 2010;77(4):593-600.
2010: John J G Tesmer; Valerie M Tesmer; David T Lodowski; Henning Steinhagen; Jochen Huber
Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
Journal of medicinal chemistry 2010;53(4):1867-70.
2010: Jeffery N Talbot; David Roman; Mary J Clark; Rebecca A Roof; John J G Tesmer; Richard Neubig; John R Traynor
Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent.
Journal of neurochemistry 2010;112(4):1026-34.
2010: Mohamed Aittaleb; Cassandra A Boguth; John J G Tesmer
Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.
Molecular pharmacology 2010;77(2):111-25.
2009: Mohamed Aittaleb; Guang Gao; Chris R Evelyn; Richard Neubig; John J G Tesmer
A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.
Cellular signalling 2009;21(11):1569-78.
2009: Chih-chin Huang; Kae Yoshino-Koh; John J G Tesmer
A surface of the kinase domain critical for the allosteric activation of G protein-coupled receptor kinases.
The Journal of biological chemistry 2009;284(25):17206-15.
2009: Rachel Sterne-Marr; P Alex Leahey; Jamee E Bresee; Heather M Dickson; Wesley Ho; Michael J Ragusa; Ryan M Donnelly; Sarah M Amie; Janet A Krywy; Elizabeth D Brookins-Danz; Somtochukwu C Orakwue; Michael J Carr; Kae Yoshino-Koh; Qianzhi Li; John J G Tesmer
GRK2 activation by receptors: role of the kinase large lobe and carboxyl-terminal tail.
Biochemistry 2009;48(20):4285-93.
2009: John J G Tesmer
Structure and function of regulator of G protein signaling homology domains.
Progress in molecular biology and translational science 2009;86():75-113.
2008: Aruna Shankaranarayanan; David M Thal; Valerie M Tesmer; David Roman; Richard Neubig; Tohru Kozasa; John J G Tesmer
Assembly of high order G alpha q-effector complexes with RGS proteins.
The Journal of biological chemistry 2008;283(50):34923-34.
2008: Puja Singh; Benlian Wang; Tadao Maeda; Krzysztof Palczewski; John J G Tesmer
Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.
The Journal of biological chemistry 2008;283(20):14053-62.
2008: John J G Tesmer
Guanylyl cyclase sees the light.
Journal of biology 2008;7(8):31.
2007: Susanne Lutz; Aruna Shankaranarayanan; Cassandra Coco; Marc Robert Ridilla; Mark R Nance; Christiane Vettel; Doris Baltus; Chris R Evelyn; Richard Neubig; Thomas Wieland; John J G Tesmer
Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Science (New York, N.Y.) 2007;318(5858):1923-7.
2007: Steven Gu; Janet He; Wing-Ting Ho; Suneela Ramineni; David M Thal; Ramanathan Natesh; John J G Tesmer; John R Hepler; Scott P Heximer
Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members.
The Journal of biological chemistry 2007;282(45):33064-75.
2007: Stacey L Williams; Susanne Lutz; Nicole K Charlie; Christiane Vettel; Michael Ailion; Cassandra Coco; John J G Tesmer; Erik M Jorgensen; Thomas Wieland; Kenneth G Miller
Trio's Rho-specific GEF domain is the missing Galpha q effector in C. elegans.
Genes & development 2007;21(21):2731-46.
2007: Xiaoyun Chen; Andrew P Boughton; John J G Tesmer; Zhan Chen
In situ investigation of heterotrimeric G protein betagamma subunit binding and orientation on membrane bilayers.
Journal of the American Chemical Society 2007;129(42):12658-9.
2007: Qianzhi Li; Mark R Nance; Rima Kulikauskas; Kevin Nyberg; Richard G Fehon; P Andrew Karplus; Anthony Bretscher; John J G Tesmer
Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain.
Journal of molecular biology 2007;365(5):1446-59.
2006: David T Lodowski; Valerie M Tesmer; Jeffrey L Benovic; John J G Tesmer
The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs.
The Journal of biological chemistry 2006;281(24):16785-93.
2006: John J G Tesmer
Pharmacology. Hitting the hot spots of cell signaling cascades.
Science (New York, N.Y.) 2006;312(5772):377-8.
2006: Barry Kreutz; Douglas M Yau; Mark R Nance; Shihori Tanabe; John J G Tesmer; Tohru Kozasa
A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins.
Biochemistry 2006;45(1):167-74.
2005: Valerie M Tesmer; Takeharu Kawano; Aruna Shankaranarayanan; Tohru Kozasa; John J G Tesmer
Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex.
Science (New York, N.Y.) 2005;310(5754):1686-90.
2005: David T Lodowski; Jennifer F Barnhill; Robyn M Pyskadlo; Rodolfo Ghirlando; Rachel Sterne-Marr; John J G Tesmer
The role of G beta gamma and domain interfaces in the activation of G protein-coupled receptor kinase 2.
Biochemistry 2005;44(18):6958-70.
2005: John J G Tesmer
A seminal study of soluble adenylyl cyclase.
Nature structural & molecular biology 2005;12(1):7-8.
2004: Peter W Day; John J G Tesmer; Rachel Sterne-Marr; Leslie C Freeman; Jeffrey L Benovic; Philip B Wedegaertner
Characterization of the GRK2 binding site of Galphaq.
The Journal of biological chemistry 2004;279(51):53643-52.
2004: Romana Kristelly; Guang Gao; John J G Tesmer
Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.
The Journal of biological chemistry 2004;279(45):47352-62.
2004: Rachel Sterne-Marr; Gurpreet K Dhami; John J G Tesmer; Stephen S G Ferguson
Characterization of GRK2 RH domain-dependent regulation of GPCR coupling to heterotrimeric G proteins.
Methods in enzymology 2004;390():310-36.
2003: Romana Kristelly; Brett T Earnest; Lakshmipriya Krishnamoorthy; John J G Tesmer
Preliminary structure analysis of the DH/PH domains of leukemia-associated RhoGEF.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 10):1859-62.
2003: David T Lodowski; Julie A Pitcher; W Darrell Capel; Robert J Lefkowitz; John J G Tesmer
Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma.
Science (New York, N.Y.) 2003;300(5623):1256-62.
2003: David T Lodowski; Jennifer F Barnhill; Julie A Pitcher; W Darrell Capel; Robert J Lefkowitz; John J G Tesmer
Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 5):936-9.
2003: Rachel Sterne-Marr; John J G Tesmer; Peter W Day; RoseAnn P Stracquatanio; Jill-Ann E Cilente; Katharine E O'Connor; Alexey N Pronin; Jeffrey L Benovic; Philip B Wedegaertner
G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits.
The Journal of biological chemistry 2003;278(8):6050-8.
2002: John J G Tesmer; Roger K Sunahara; David A Fancy; Alfred G Gilman; Stephen R Sprang
Crystallization of complex between soluble domains of adenylyl cyclase and activated Gs alpha.
Methods in enzymology 2002;345():198-206.
2000: John J G Tesmer; Carmen W Dessauer; Roger K Sunahara; L D Murray; R A Johnson; Alfred G Gilman; Stephen R Sprang
Molecular basis for P-site inhibition of adenylyl cyclase.
Biochemistry 2000;39(47):14464-71.
1999: Julie A Pitcher; John J G Tesmer; Jennifer L R Freeman; W Darrell Capel; W C Stone; Robert J Lefkowitz
Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases.
The Journal of biological chemistry 1999;274(49):34531-4.
1999: John J G Tesmer; Roger K Sunahara; R A Johnson; G Gosselin; Alfred G Gilman; Stephen R Sprang
Two-metal-Ion catalysis in adenylyl cyclase.
Science (New York, N.Y.) 1999;285(5428):756-60.
1999: BA Posner; S Mukhopadhyay; John J G Tesmer; Alfred G Gilman; Elliott M Ross
Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue.
Biochemistry 1999;38(24):7773-9.
1999: Carmen W Dessauer; John J G Tesmer; Stephen R Sprang; Alfred G Gilman
The interactions of adenylate cyclases with P-site inhibitors.
Trends in pharmacological sciences 1999;20(5):205-10.
1998: John J G Tesmer; Stephen R Sprang
The structure, catalytic mechanism and regulation of adenylyl cyclase.
Current opinion in structural biology 1998;8(6):713-9.
1998: Carmen W Dessauer; John J G Tesmer; Stephen R Sprang; Alfred G Gilman
Identification of a Gialpha binding site on type V adenylyl cyclase.
The Journal of biological chemistry 1998;273(40):25831-9.
1998: Roger K Sunahara; Annie Beuve; John J G Tesmer; Stephen R Sprang; David L Garbers; Alfred G Gilman
Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases.
The Journal of biological chemistry 1998;273(26):16332-8.
1997: John J G Tesmer; Roger K Sunahara; Alfred G Gilman; Stephen R Sprang
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.
Science (New York, N.Y.) 1997;278(5345):1907-16.
1997: Roger K Sunahara; John J G Tesmer; Alfred G Gilman; Stephen R Sprang
Crystal structure of the adenylyl cyclase activator Gsalpha.
Science (New York, N.Y.) 1997;278(5345):1943-7.
1997: John J G Tesmer; berman david; Alfred G Gilman; Stephen R Sprang
Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis.
Cell 1997;89(2):251-61.
1996: John J G Tesmer; TJ Klem; M L Deras; V Jo Davisson; Janet L Smith
The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families.
Nature structural biology 1996;3(1):74-86.
1994: John J G Tesmer; Timothy L Stemmler; James Penner-Hahn; V Jo Davisson; Janet L Smith
Preliminary X-ray analysis of Escherichia coli GMP synthetase: determination of anomalous scattering factors for a cysteinyl mercury derivative.
Proteins 1994;18(4):394-403.
1992: P S Vermersch; John J G Tesmer; Florante A Quiocho
Protein-ligand energetics assessed using deoxy and fluorodeoxy sugars in equilibrium binding and high resolution crystallographic studies.
Journal of molecular biology 1992;226(4):923-9.
1991: P S Vermersch; D D Lemon; John J G Tesmer; Florante A Quiocho
Sugar-binding and crystallographic studies of an arabinose-binding protein mutant (Met108Leu) that exhibits enhanced affinity and altered specificity.
Biochemistry 1991;30(28):6861-6.
1990: P S Vermersch; John J G Tesmer; D D Lemon; Florante A Quiocho
A Pro to Gly mutation in the hinge of the arabinose-binding protein enhances binding and alters specificity. Sugar-binding and crystallographic studies.
The Journal of biological chemistry 1990;265(27):16592-603.