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Bernard Testa

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Federica Vacondio; Claudia Silva; sha mor; Bernard Testa
Qualitative structure-metabolism relationships in the hydrolysis of carbamates.
Angelo Carotti; Marco Catto; Francesco Leonetti; Francesco Campagna; Ramón Soto-Otero; Estefanía Méndez-Alvarez; Ulrike Thull; Bernard Testa; Cosimo Altomare
Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives.
Giulia Caron; Giuseppe Ermondi; Bernard Testa
Predicting the oxidative metabolism of statins: an application of the MetaSite algorithm.

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All Publications

2010: Federica Vacondio; Claudia Silva; sha mor; Bernard Testa
Qualitative structure-metabolism relationships in the hydrolysis of carbamates.
Drug metabolism reviews 2010;42(4):551-89.
2007: Angelo Carotti; Marco Catto; Francesco Leonetti; Francesco Campagna; Ramón Soto-Otero; Estefanía Méndez-Alvarez; Ulrike Thull; Bernard Testa; Cosimo Altomare
Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives.
Journal of medicinal chemistry 2007;50(22):5364-71.
2007: Giulia Caron; Giuseppe Ermondi; Bernard Testa
Predicting the oxidative metabolism of statins: an application of the MetaSite algorithm.
Pharmaceutical research 2007;24(3):480-501.
2006: Marc-Etienne Castella; Marianne Reist; Joachim M Mayer; Jean-Jacques Turban; Bernard Testa; Claire Boursier-Neyret; Bernard Walther; Jean-Marie Delbos; Pierre-Alain Carrupt
Development of an in vitro rat intestine segmental perfusion model to investigate permeability and predict oral fraction absorbed.
Pharmaceutical research 2006;23(7):1543-53.
2006: Angelo Carotti; Cosimo Altomare; Marco Catto; Carmela Gnerre; Luciana Summo; Agostino De Marco; Sarah Rose; Peter Jenner; Bernard Testa
Lipophilicity plays a major role in modulating the inhibition of monoamine oxidase B by 7-substituted coumarins.
Chemistry & biodiversity 2006;3(2):134-49.
2005: Cinzia Stella; Alexandra Galland; Xiangli Liu; Bernard Testa; Serge Rudaz; Jean-Luc Veuthey; Pierre-Alain Carrupt
Novel RPLC stationary phases for lipophilicity measurement: solvatochromic analysis of retention mechanisms for neutral and basic compounds.
Journal of separation science 2005;28(17):2350-62.
2005: Bernard Testa; Anne-Loyse Balmat; Anthony Long; Philip Judson
Predicting drug metabolism--an evaluation of the expert system METEOR.
Chemistry & biodiversity 2005;2(7):872-85.
2004: Federica Vacondio; sha mor; Claudia Silva; Valentina Zuliani; Mirko Rivara; Silvia Rivara; Fabrizio Bordi; Pier Vincenzo Plazzi; Francesca Magnanini; Simona Bertoni; Vigilio Ballabeni; Elisabetta Barocelli; Pierre-Alain Carrupt; Bernard Testa
Imidazole H3-antagonists: relationship between structure and ex vivo binding to rat brain H3-receptors.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;23(1):89-98.
2004: Corinne Brühlmann; Andrew Marston; Kurt Hostettmann; Pierre-Alain Carrupt; Bernard Testa
Screening of non-alkaloidal natural compounds as acetylcholinesterase inhibitors.
Chemistry & biodiversity 2004;1(6):819-29.
2004: Georgette Plemper van Balen; Catherine a Marca Martinet; Giulia Caron; Géraldine Bouchard; Marianne Reist; Pierre-Alain Carrupt; Roberta Fruttero; Alberto Gasco; Bernard Testa
Liposome/water lipophilicity: methods, information content, and pharmaceutical applications.
Medicinal research reviews 2004;24(3):299-324.
2004: Sandrine Geinoz; Richard H Guy; Bernard Testa; Pierre-Alain Carrupt
Quantitative structure-permeation relationships (QSPeRs) to predict skin permeation: a critical evaluation.
Pharmaceutical research 2004;21(1):83-92.
2003: Xiangli Liu; Géraldine Bouchard; Hubert H Girault; Bernard Testa; Pierre-Alain Carrupt
Partition coefficients of ionizable compounds in o-nitrophenyl octyl ether/water measured by the potentiometric method.
Analytical chemistry 2003;75(24):7036-9.
2003: Jean-Paul Tillement; Bernard Testa; Françoise Brée
Compared pharmacological characteristics in humans of racemic cetirizine and levocetirizine, two histamine H1-receptor antagonists.
Biochemical pharmacology 2003;66(7):1123-6.
2003: Corinne Planchamp; Thanh L Vu; Joachim M Mayer; Marianne Reist; Bernard Testa
Hepatocyte hollow-fibre bioreactors: design, set-up, validation and applications.
The Journal of pharmacy and pharmacology 2003;55(9):1181-98.
2003: Agnes Taillardat-Bertschinger; Pierre-Alain Carrupt; Francesco Barbato; Bernard Testa
Immobilized artificial membrane HPLC in drug research.
Journal of medicinal chemistry 2003;46(5):655-65.
2003: Silvia Rivara; sha mor; Fabrizio Bordi; Claudia Silva; Valentina Zuliani; Federica Vacondio; Giovanni Morini; Pier Vincenzo Plazzi; Pierre-Alain Carrupt; Bernard Testa
Synthesis and three-dimensional quantitative structure-activity relationship analysis of H3 receptor antagonists containing a neutral heterocyclic polar group.
Drug design and discovery 2003;18(2-3):65-79.
2003: Lemont B Kier; Chao-Kun Cheng; Bernard Testa
Studies of ligand diffusion pathways over a protein surface.
Journal of chemical information and computer sciences 2003;43(1):255-8.
2002: Angelo Carotti; Antonio Carrieri; Stefano Chimichi; Marco Boccalini; Barbara Cosimelli; Carmela Gnerre; Andrea Carotti; Pierre-Alain Carrupt; Bernard Testa
Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies.
Bioorganic & medicinal chemistry letters 2002;12(24):3551-5.
2002: Séb REY; Pierre-Alain Carrupt; Bernard Testa
The Hydrogen-Bond: computational approaches and applications to drug design.
Annales pharmaceutiques françaises 2002;60(6):386-96.
2002: Sandrine Geinoz; Séb REY; Gilles Boss; Annette L Bunge; Richard H Guy; Pierre-Alain Carrupt; Marianne Reist; Bernard Testa
Quantitative structure-permeation relationships for solute transport across silicone membranes.
Pharmaceutical research 2002;19(11):1622-9.
2002: Géraldine Bouchard; Pierre-Alain Carrupt; Bernard Testa; Véronique Gobry; Hubert H Girault
Lipophilicity and solvation of anionic drugs.
Chemistry (Weinheim an der Bergstrasse, Germany) 2002;8(15):3478-84.
2002: Géraldine Bouchard; Alessandra Pagliara; Pierre-Alain Carrupt; Bernard Testa; Véronique Gobry; Hubert H Girault
Theoretical and experimental exploration of the lipophilicity of zwitterionic drugs in the 1,2-dichloroethane/water system.
Pharmaceutical research 2002;19(8):1150-9.
2002: Fred Ooms; Peter Weber; Pierre-Alain Carrupt; Bernard Testa
A simple model to predict blood-brain barrier permeation from 3D molecular fields.
Biochimica et biophysica acta 2002;1587(2-3):118-25.
2002: Agnes Taillardat-Bertschinger; Catherine A Marca Martinet; Pierre-Alain Carrupt; Marianne Reist; Giulia Caron; Roberta Fruttero; Bernard Testa
Molecular factors influencing retention on immobilized artifical membranes (IAM) compared to partitioning in liposomes and n-octanol.
Pharmaceutical research 2002;19(6):729-37.
2002: Bernard Testa; Lemont B Kier; Chao-Kun Cheng
A cellular automata model of water structuring by a chiral solute.
Journal of chemical information and computer sciences 2002;42(3):712-6.
2002: Georgette Plemper van Balen; Pierre-Alain Carrupt; Didier Morin; Jean-Paul Tillement; Alain Le Ridant; Bernard Testa
Recognition forces involved in mitochondrial binding to a low-affinity trimetazidine binding site related to anti-ischemic activity.
Biochemical pharmacology 2002;63(9):1691-7.
2002: Fred Ooms; Johan Wouters; Olivier Oscari; Thierry Happaerts; Géraldine Bouchard; Pierre-Alain Carrupt; Bernard Testa; Didier M Lambert
Exploration of the pharmacophore of 3-alkyl-5-arylimidazolidinediones as new CB(1) cannabinoid receptor ligands and potential antagonists: synthesis, lipophilicity, affinity, and molecular modeling.
Journal of medicinal chemistry 2002;45(9):1748-56.
2002: Agnes Taillardat-Ertschinger; Alexandra Galland; Pierre-Alain Carrupt; Bernard Testa
Immobilized artificial membrane liquid chromatography: proposed guidelines for technical optimization of retention measurements.
Journal of chromatography. A 2002;953(1-2):39-53.
2002: Agnes Taillardat-Bertschinger; Pierre-Alain Carrupt; Bernard Testa
The relative partitioning of neutral and ionised compounds in sodium dodecyl sulfate micelles measured by micellar electrokinetic capillary chromatography.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2002;15(2):225-34.
2002: Markus Kosel; Carmela Gnerre; Pierre Voirol; M Amey; B Rochat; Constantin Bouras; Bernard Testa; Pierre Baumann
In vitro biotransformation of the selective serotonin reuptake inhibitor citalopram, its enantiomers and demethylated metabolites by monoamine oxidase in rat and human brain preparations.
Molecular psychiatry 2002;7(2):181-8.
2001: Véronique Gobry; Sorina M Ulmeanu; Frédéric Reymond; Géraldine Bouchard; Pierre-Alain Carrupt; Bernard Testa; Hubert H Girault
Generalization of ionic partition diagrams to lipophilic compounds and to biphasic systems with variable phase volume ratios.
Journal of the American Chemical Society 2001;123(43):10684-90.
2001: N Chapuis; Corinne Brühlmann; Marianne Reist; Pierre-Alain Carrupt; Joachim M Mayer; Bernard Testa
The esterase-like activity of serum albumin may be due to cholinesterase contamination.
Pharmaceutical research 2001;18(10):1435-9.
2001: Corinne Brühlmann; Fred Ooms; Pierre-Alain Carrupt; Bernard Testa; Marco Catto; Francesco Leonetti; Cosimo Altomare; Angelo Carotti
Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase.
Journal of medicinal chemistry 2001;44(19):3195-8.
2001: Carmela Gnerre; Gilsane von Poser; Alexandre Ferraz; Alice Viana; Bernard Testa; S M K Rates
Monoamine oxidase inhibitory activity of some Hypericum species native to South Brazil.
The Journal of pharmacy and pharmacology 2001;53(9):1273-9.
2001: Carmela Gnerre; Markus Kosel; Pierre Baumann; Pierre-Alain Carrupt; Bernard Testa
Interaction of psychotropic drugs with monoamine oxidase in rat brain.
The Journal of pharmacy and pharmacology 2001;53(8):1125-30.
2001: A Salvi; Pierre-Alain Carrupt; Jean-Paul Tillement; Bernard Testa
Structural damage to proteins caused by free radicals: asessment, protection by antioxidants, and influence of protein binding.
Biochemical pharmacology 2001;61(10):1237-42.
2001: Géraldine Bouchard; Pierre-Alain Carrupt; Bernard Testa; Véronique Gobry; Hubert H Girault
The apparent lipophilicity of quaternary ammonium ions is influenced by galvani potential difference, not ion-pairing: a cyclic voltammetry study.
Pharmaceutical research 2001;18(5):702-8.
2001: G Plember van Balen; Giulia Caron; Giuseppe Ermondi; Alessandra Pagliara; T Grandi; Géraldine Bouchard; Roberta Fruttero; Pierre-Alain Carrupt; Bernard Testa
Lipophilicity behaviour of the Zwitterionic antihistamine cetirizine in phosphatidylcholine liposomes/water systems.
Pharmaceutical research 2001;18(5):694-701.
2001: Séb REY; Giulia Caron; Giuseppe Ermondi; P Gaillard; Alessandra Pagliara; Pierre-Alain Carrupt; Bernard Testa
Development of molecular hydrogen-bonding potentials (MHBPs) and their application to structure-permeation relations.
Journal of molecular graphics & modelling 2001;19(6):521-35, 594-7.
2000: Carmela Gnerre; Marco Catto; Francesco Leonetti; P Weber; Pierre-Alain Carrupt; Cosimo Altomare; Angelo Carotti; Bernard Testa
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activities, QSARs, and 3D-QSARs.
Journal of medicinal chemistry 2000;43(25):4747-58.
2000: Marianne Reist; M Roy-de Vos; J P Montseny; Joachim M Mayer; Pierre-Alain Carrupt; Yann Berger; Bernard Testa
Very slow chiral inversion of clopidogrel in rats: a pharmacokinetic and mechanistic investigation.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(12):1405-10.
2000: Bernard Testa; A J Bojarski
Molecules as complex adaptative systems: constrained molecular properties and their biochemical significance.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;11 Suppl 2():S3-14.
2000: M Cuendet; O Potterat; A Salvi; Bernard Testa; Kurt Hostettmann
A stilbene and dihydrochalcones with radical scavenging activities from Loiseleuria procumbens.
Phytochemistry 2000;54(8):871-4.
2000: P Crivori; G Cruciani; Pierre-Alain Carrupt; Bernard Testa
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Journal of medicinal chemistry 2000;43(11):2204-16.
2000: Didier Morin; Rosa Sapena; Aziz Elimadi; Bernard Testa; Serge Labidalle; Alain Le Ridant; Jean-Paul Tillement
[(3)H]-trimetazidine mitochondrial binding sites: regulation by cations, effect of trimetazidine derivatives and other agents and interaction with an endogenous substance.
British journal of pharmacology 2000;130(3):655-63.
1999: Alessandra Pagliara; Marianne Reist; Sandrine Geinoz; Pierre-Alain Carrupt; Bernard Testa
Evaluation and prediction of drug permeation.
The Journal of pharmacy and pharmacology 1999;51(12):1339-57.
1999: Frédéric Reymond; G Steyaert; Pierre-Alain Carrupt; D Morin; J P Tillement; Hubert H Girault; Bernard Testa
The pH-partition profile of the anti-ischemic drug trimetazidine may explain its reduction of intracellular acidosis.
Pharmaceutical research 1999;16(5):616-24.
1999: T Grandi; Fabio Sparatore; Carmela Gnerre; P Crivori; Pierre-Alain Carrupt; Bernard Testa
Monoamine oxidase inhibitor properties of some benzazoles: structure-activity relationships.
AAPS pharmSci 1999;1(4):E16.
1998: Marianne Reist; Pierre-Alain Carrupt; E Francotte; Bernard Testa
Chiral inversion and hydrolysis of thalidomide: mechanisms and catalysis by bases and serum albumin, and chiral stability of teratogenic metabolites.
Chemical research in toxicology 1998;11(12):1521-8.
1998: Bernard Testa; J M Mayer
Design of intramolecularly activated prodrugs.
Drug metabolism reviews 1998;30(4):787-807.
1998: Kevin St P McNaught; Pierre-Alain Carrupt; Cosimo Altomare; Saverio Cellamare; A Carotti; Bernard Testa; Peter Jenner; CD Marsden
Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease.
Biochemical pharmacology 1998;56(8):921-33.
1998: Cosimo Altomare; Saverio Cellamare; Luciana Summo; Marco Catto; Angelo Carotti; U Thull; Pierre-Alain Carrupt; Bernard Testa; H Stoeckli-Evans
Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships.
Journal of medicinal chemistry 1998;41(20):3812-20.
1998: Roberta Fruttero; Giulia Caron; E Fornatto; donatella boschi; Giuseppe Ermondi; Alberto Gasco; Pierre-Alain Carrupt; Bernard Testa
Mechanisms of liposomes/water partitioning of (p-methylbenzyl)alkylamines.
Pharmaceutical research 1998;15(9):1407-13.
1998: B Rochat; Markus Kosel; G Boss; Bernard Testa; M Gillet; Pierre Baumann
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
Biochemical pharmacology 1998;56(1):15-23.
1998: Françoise Hervé; Giulia Caron; Jean-Claude Duché; P Gaillard; N Abd Rahman; A Tsantili-Kakoulidou; Pierre-Alain Carrupt; Philippe d'Athis; Jean-Paul Tillement; Bernard Testa
Ligand specificity of the genetic variants of human alpha1-acid glycoprotein: generation of a three-dimensional quantitative structure-activity relationship model for drug binding to the A variant.
Molecular pharmacology 1998;54(1):129-38.
1998: J Ancerewicz; Eugenia Migliavacca; Pierre-Alain Carrupt; Bernard Testa; Françoise Brée; Roland Zini; Jean-Paul Tillement; Serge Labidalle; D Guyot; AM Chauvet-Monges; AD Crevat; Alain Le Ridant
Structure-property relationships of trimetazidine derivatives and model compounds as potential antioxidants.
Free radical biology & medicine 1998;25(1):113-20.
1998: Bernard Testa; J Mayer
Molecular toxicology and the medicinal chemist.
Farmaco (Società chimica italiana : 1989) 1998;53(4):287-91.
1998: Didier Morin; Aziz Elimadi; Rosa Sapena; AD Crevat; Pierre-Alain Carrupt; Bernard Testa; Jean-Paul Tillement
Evidence for the existence of [3H]-trimetazidine binding sites involved in the regulation of the mitochondrial permeability transition pore.
British journal of pharmacology 1998;123(7):1385-94.
1998: Alessandra Pagliara; Bernard Testa; Pierre-Alain Carrupt; P Jolliet; Christophe Morin; D Morin; S Urien; Jean-Paul Tillement; J P Rihoux
Molecular properties and pharmacokinetic behavior of cetirizine, a zwitterionic H1-receptor antagonist.
Journal of medicinal chemistry 1998;41(6):853-63.
1997: Bernard Testa; Alessandra Pagliara; Pierre-Alain Carrupt
The molecular behaviour of cetirizine.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1997;27 Suppl 2():13-8; discussion 54-6.
1997: sha mor; Fabrizio Bordi; Claudia Silva; Silvia Rivara; P Crivori; Pier Vincenzo Plazzi; Vigilio Ballabeni; A Caretta; Elisabetta Barocelli; Mariannina Impicciatore; Pierre-Alain Carrupt; Bernard Testa
H3-receptor antagonists: synthesis and structure-activity relationships of para- and meta-substituted 4(5)-phenyl-2-[[2-[4(5)-imidazolyl]ethyl]thio]imidazoles.
Journal of medicinal chemistry 1997;40(16):2571-8.
1997: Bernard Testa; Lemont B Kier; Pierre-Alain Carrupt
A systems approach to molecular structure, intermolecular recognition, and emergence-dissolvence in medicinal research.
Medicinal research reviews 1997;17(4):303-26.
1997: P Jolliet; N Simon; Françoise Brée; S Urien; Alessandra Pagliara; Pierre-Alain Carrupt; Bernard Testa; Jean-Paul Tillement
Blood-to-brain transfer of various oxicams: effects of plasma binding on their brain delivery.
Pharmaceutical research 1997;14(5):650-6.
1997: A Salvi; Pierre-Alain Carrupt; Joachim M Mayer; Bernard Testa
Esterase-like activity of human serum albumin toward prodrug esters of nicotinic acid.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(4):395-8.
1996: A Salvi; Joachim M Mayer; Pierre-Alain Carrupt; Bernard Testa
A continuous fluorimetric method to monitor the enzymatic hydrolysis of medicinal esters.
Journal of pharmaceutical and biomedical analysis 1996;15(2):149-55.
1996: Kevin St P McNaught; U Thull; Pierre-Alain Carrupt; Cosimo Altomare; Saverio Cellamare; Angelo Carotti; Bernard Testa; Peter Jenner; CD Marsden
Nigral cell loss produced by infusion of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(3):265-74.
1996: Giulia Caron; Pierre-Alain Carrupt; Bernard Testa; Giuseppe Ermondi; Alberto Gasco
Insight into the lipophilicity of the aromatic N-oxide moiety.
Pharmaceutical research 1996;13(8):1186-90.
1996: Kevin St P McNaught; U Thull; Pierre-Alain Carrupt; Cosimo Altomare; Saverio Cellamare; Angelo Carotti; Bernard Testa; Peter Jenner; CD Marsden
Inhibition of [3H]dopamine uptake into striatal synaptosomes by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Biochemical pharmacology 1996;52(1):29-34.
1996: Kevin St P McNaught; U Thull; Pierre-Alain Carrupt; Cosimo Altomare; Saverio Cellamare; Angelo Carotti; Bernard Testa; Peter Jenner; CD Marsden
Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration.
Biochemical pharmacology 1996;51(11):1503-11.
1996: M Roy-de Vos; Joachim M Mayer; J C Etter; Bernard Testa
Clofibric acid increases the undirectional chiral inversion of ibuprofen in rat liver preparations.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(6):571-82.
1996: Pierre-Alain Carrupt; P Gaillard; F Billois; P Weber; Bernard Testa
[Molecular lipophilicity potential (MLP) in drug design. Complementing theoretical tools with experimental results].
Journal de pharmacie de Belgique 1996;51(3):170-5.
1996: M D Salducci; AM Chauvet-Monges; Jean-Paul Tillement; E Albengres; Bernard Testa; Pierre-Alain Carrupt; AD Crevat
Trimetazidine reverses calcium accumulation and impairment of phosphorylation induced by cyclosporine A in isolated rat liver mitochondria.
The Journal of pharmacology and experimental therapeutics 1996;277(1):417-22.
1996: Kevin St P McNaught; U Thull; Pierre-Alain Carrupt; Cosimo Altomare; Saverio Cellamare; Angelo Carotti; Bernard Testa; Peter Jenner; CD Marsden
Toxicity to PC12 cells of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Neuroscience letters 1996;206(1):37-40.
1996: Bernard Testa; Pierre-Alain Carrupt; P Gaillard; F Billois; P Weber
Lipophilicity in molecular modeling.
Pharmaceutical research 1996;13(3):335-43.
1996: P Gaillard; Pierre-Alain Carrupt; Bernard Testa; P Schambel
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.
Journal of medicinal chemistry 1996;39(1):126-34.
1996: Jean-Paul Tillement; A Crevat; Bernard Testa; A Le Ridant
[Pharmacological modulation of mitochondrial oxidative phosphorylation: inhibition by cyclosporine A, restoration by trimetazidine].
Annales pharmaceutiques françaises 1996;54(6):268-71.
1995: Kevin St P McNaught; U Thull; Pierre-Alain Carrupt; Cosimo Altomare; Saverio Cellamare; Angelo Carotti; Bernard Testa; Peter Jenner; CD Marsden
Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Biochemical pharmacology 1995;50(11):1903-11.
1995: B Pirard; Pierre-Alain Carrupt; Bernard Testa; R S Tsai; P Berthelot; Claude Vaccher; M Debaert; François Durant
Structure-affinity relationships of baclofen and 3-heteroaromatic analogues.
Bioorganic & medicinal chemistry 1995;3(11):1537-45.
1995: D Meyer; M H Fouchet; M Petta; Pierre-Alain Carrupt; P Gaillard; Bernard Testa
Stabilization of the hydrophilic sphere of iobitridol, an iodinated contrast agent, as revealed by experimental and computational investigations.
Pharmaceutical research 1995;12(11):1583-91.
1995: M Brunner-Guenat; Pierre-Alain Carrupt; G Lisa; Bernard Testa; S Rose; K Thomas; Peter Jenner; P Ventura
Esters of L-dopa: structure-hydrolysis relationships and ability to induce circling behaviour in an experimental model of hemiparkinsonism.
The Journal of pharmacy and pharmacology 1995;47(10):861-9.
1995: S Kneubühler; U Thull; Cosimo Altomare; V Carta; P Gaillard; Pierre-Alain Carrupt; Angelo Carotti; Bernard Testa
Inhibition of monoamine oxidase-B by 5H-indeno[1,2-c]pyridazines: biological activities, quantitative structure-activity relationships (QSARs) and 3D-QSARs.
Journal of medicinal chemistry 1995;38(19):3874-83.
1995: U Thull; S Kneubühler; P Gaillard; Pierre-Alain Carrupt; Bernard Testa; Cosimo Altomare; Angelo Carotti; Peter Jenner; Kevin St P McNaught
Inhibition of monoamine oxidase by isoquinoline derivatives. Qualitative and 3D-quantitative structure-activity relationships.
Biochemical pharmacology 1995;50(6):869-77.
1995: Kevin St P McNaught; Cosimo Altomare; Saverio Cellamare; Angelo Carotti; U Thull; Pierre-Alain Carrupt; Bernard Testa; Peter Jenner; CD Marsden
Inhibition of alpha-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Neuroreport 1995;6(8):1105-8.
1995: Saïk Urien; Y Giroud; R S Tsai; Pierre-Alain Carrupt; F Brée; Bernard Testa; Jean-Paul Tillement
Mechanism of ligand binding to alpha 1-acid glycoprotein (orosomucoid): correlated thermodynamic factors and molecular parameters of polarity.
The Biochemical journal 1995;306 ( Pt 2)():545-9.
1995: Cosimo Altomare; Saverio Cellamare; Angelo Carotti; G Casini; M Ferappi; Enrico Gavuzzo; F Mazza; P T Carrupt; P Gaillard; Bernard Testa
X-ray crystal structure, partitioning behavior, and molecular modeling study of piracetam-type nootropics: insights into the pharmacophore.
Journal of medicinal chemistry 1995;38(1):170-9.
1995: Joachim M Mayer; Bernard Testa; M Roy-de Vos; C Audergon; J C Etter
Interactions between the in vitro metabolism of xenobiotics and fatty acids. The case of ibuprofen and other chiral profens.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1995;17():499-513.
1994: L Rocha; Andrew Marston; M A Kaplan; H Stoeckli-Evans; U Thull; Bernard Testa; Kurt Hostettmann
An antifungal gamma-pyrone and xanthones with monoamine oxidase inhibitory activity from Hypericum brasiliense.
Phytochemistry 1994;36(6):1381-5.
1994: U Thull; Bernard Testa
Screening of unsubstituted cyclic compounds as inhibitors of monoamine oxidases.
Biochemical pharmacology 1994;47(12):2307-10.
1994: P Gaillard; Pierre-Alain Carrupt; Bernard Testa; A Boudon
Molecular lipophilicity potential, a tool in 3D QSAR: method and applications.
Journal of computer-aided molecular design 1994;8(2):83-96.
1994: H van Gelderen; Joachim M Mayer; Bernard Testa
Thermodynamic studies of enzyme catalysis. What can we learn about specificity and mechanism?
Biochemical pharmacology 1994;47(5):753-6.
1994: R S Tsai; Pierre-Alain Carrupt; Bernard Testa; J Caldwell
Structure-genotoxicity relationships of allylbenzenes and propenylbenzenes: a quantum chemical study.
Chemical research in toxicology 1994;7(1):73-6.
1994: H Van Gelderen; Joachim M Mayer; Saverio Cellamare; Bernard Testa
The temperature dependence of steady-state kinetics: what can be learned about pig liver esterase stereospecificity?
Chirality 1994;6(1):11-6.
1994: Joachim M Mayer; M Roy-De Vos; C Audergon; Bernard Testa; J C Etter
Interactions of anti-inflammatory 2-arylpropionates (profens) with the metabolism of fatty acids: in vitro studies.
International journal of tissue reactions 1994;16(2):59-72.
1993: F Brée; Saïk Urien; P Nguyen; Jean-Paul Tillement; A Steiner; C Vallat-Molliet; Bernard Testa; J Visy; M Simonyi
Human serum albumin conformational changes as induced by tenoxicam and modified by simultaneous diazepam binding.
The Journal of pharmacy and pharmacology 1993;45(12):1050-3.
1993: N el Tayar; Alan E Mark; P Vallat; R M Brunne; Bernard Testa; W F van Gunsteren
Solvent-dependent conformation and hydrogen-bonding capacity of cyclosporin A: evidence from partition coefficients and molecular dynamics simulations.
Journal of medicinal chemistry 1993;36(24):3757-64.
1993: U Thull; S Kneubühler; Bernard Testa; M F Borges; M M Pinto
Substituted xanthones as selective and reversible monoamine oxidase A (MAO-A) inhibitors.
Pharmaceutical research 1993;10(8):1187-90.
1993: Saïk Urien; F Brée; Bernard Testa; Jean-Paul Tillement
pH-dependence of warfarin binding to alpha 1-acid glycoprotein (orosomucoid).
The Biochemical journal 1993;289 ( Pt 3)():767-70.
1993: R S Tsai; Pierre-Alain Carrupt; Bernard Testa; P Gaillard; N el Tayar; Thomas Högberg
Effects of solvation on the ionization and conformation of raclopride and other antidopaminergic 6-methoxysalicylamides: insight into the pharmacophore.
Journal of medicinal chemistry 1993;36(2):196-204.
1993: Bernard Testa; Pierre-Alain Carrupt; J Gal
The so-called "interconversion" of stereoisomeric drugs: an attempt at clarification.
Chirality 1993;5(3):105-11.
1992: S Müller; Joachim M Mayer; J C Etter; Bernard Testa
Influence of palmitate and benzoate on the unidirectional chiral inversion of ibuprofen in isolated rat hepatocytes.
Biochemical pharmacology 1992;44(7):1468-70.
1992: A Steiner; Joachim M Mayer; Bernard Testa
Nicotinate esters: their binding to and hydrolysis by human serum albumin.
The Journal of pharmacy and pharmacology 1992;44(9):745-9.
1992: Cosimo Altomare; Pierre-Alain Carrupt; P Gaillard; N el Tayar; Bernard Testa; Angelo Carotti
Quantitative structure-metabolism relationship analyses of MAO-mediated toxication of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and analogues.
Chemical research in toxicology 1992;5(3):366-75.
1992: A Durrer; G N Wernly-Chung; G Boss; Bernard Testa
Enzymic hydrolysis of nicotinate esters: comparison between plasma and liver catalysis.
Xenobiotica; the fate of foreign compounds in biological systems 1992;22(3):273-82.
1991: Saïk Urien; F Brée; Bernard Testa; Jean-Paul Tillement
pH-dependency of basic ligand binding to alpha 1-acid glycoprotein (orosomucoid).
The Biochemical journal 1991;280 ( Pt 1)():277-80.
1991: N el Tayar; R S Tsai; Bernard Testa; Pierre-Alain Carrupt; C Hansch; A Leo
Percutaneous penetration of drugs: a quantitative structure-permeability relationship study.
Journal of pharmaceutical sciences 1991;80(8):744-9.
1991: A Durrer; B Walther; A Racciatti; G Boss; Bernard Testa
Structure-metabolism relationships in the hydrolysis of nicotinate esters by rat liver and brain subcellular fractions.
Pharmaceutical research 1991;8(7):832-9.
1991: N el Tayar; R S Tsai; Bernard Testa; Pierre-Alain Carrupt; A Leo
Partitioning of solutes in different solvent systems: the contribution of hydrogen-bonding capacity and polarity.
Journal of pharmaceutical sciences 1991;80(6):590-8.
1991: Pierre-Alain Carrupt; Bernard Testa; A Bechalany; N el Tayar; P Descas; D Perrissoud
Morphine 6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicity.
Journal of medicinal chemistry 1991;34(4):1272-5.
1991: Cosimo Altomare; R S Tsai; N el Tayar; Bernard Testa; Angelo Carotti; Saverio Cellamare; Pier G De Benedetti
Determination of lipophilicity and hydrogen-bond donor acidity of bioactive sulphonyl-containing compounds by reversed-phase HPLC and centrifugal partition chromatography and their application to structure-activity relations.
The Journal of pharmacy and pharmacology 1991;43(3):191-7.
1991: R S Tsai; N el Tayar; Bernard Testa; Y Ito
Toroidal coil centrifugal partition chromatography, a method for measuring partition coefficients.
Journal of chromatography 1991;538(1):119-23.
1990: Bernard Testa
Mechanisms of inhibition of xenobiotic-metabolizing enzymes.
Xenobiotica; the fate of foreign compounds in biological systems 1990;20(11):1129-37.
1990: G Maret; N el Tayar; Pierre-Alain Carrupt; Bernard Testa; Peter Jenner; M Baird
Toxication of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and analogs by monoamine oxidase. A structure-reactivity relationship study.
Biochemical pharmacology 1990;40(4):783-92.
1990: Bernard Testa
[Chiral drugs: pharmacological tools and/or therapeutic problems?].
Schweizerische medizinische Wochenschrift 1990;120(26):953-5.
1990: S Müller; Joachim M Mayer; J C Etter; Bernard Testa
Metabolic chiral inversion of ibuprofen in isolated rat hepatocytes.
Chirality 1990;2(2):74-8.
1990: G Maret; Bernard Testa; Peter Jenner; N el Tayar; Pierre-Alain Carrupt
The MPTP story: MAO activates tetrahydropyridine derivatives to toxins causing parkinsonism.
Drug metabolism reviews 1990;22(4):291-332.
1990: Bernard Testa; W F Trager
Racemates versus enantiomers in drug development: dogmatism or pragmatism?
Chirality 1990;2(3):129-33.
1989: A Durrer; B Walther; A Racciatti; Bernard Testa
Convenient method for the analysis of nicotinic acid as a metabolite of nicotinate esters in various tissue homogenates.
Journal of chromatography 1989;495():256-62.
1989: H van de Waterbeemd; N el Tayar; Pierre-Alain Carrupt; Bernard Testa
Pattern recognition study of QSAR substituent descriptors.
Journal of computer-aided molecular design 1989;3(2):111-32.
1989: B Walther; Pierre-Alain Carrupt; H Van de Waterbeemd; N el Tayar; Bernard Testa
Lipophilicity and conformational behaviour of substituted xanthines.
Progress in clinical and biological research 1989;291():67-70.
1989: H Van de Waterbeemd; Bernard Testa; Pierre-Alain Carrupt; N el Tayar
Multivariate data analyses of QSAR parameters.
Progress in clinical and biological research 1989;291():123-6.
1989: Bernard Testa
Mechanisms of chiral recognition in xenobiotic metabolism and drug-receptor interactions.
Chirality 1989;1(1):7-9.
1989: N el Tayar; H Van de Waterbeemd; Pierre-Alain Carrupt; Bernard Testa
Beta-adrenoceptor modeling based on MEP studies.
Progress in clinical and biological research 1989;291():265-8.
1989: S Collin; G Evrard; D P Vercauteren; François Durant; Pierre-Alain Carrupt; H van de Waterbeemd; Bernard Testa
Stereoelectronic study of zetidoline, a dopamine D2 receptor antagonist.
Journal of medicinal chemistry 1989;32(1):38-42.
1988: N el Tayar; Pierre-Alain Carrupt; H Van de Waterbeemd; Bernard Testa
Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists.
Journal of medicinal chemistry 1988;31(11):2072-81.
1988: M Mesnil; Bernard Testa; Peter Jenner
Ex vivo inhibition of rat brain cytochrome P-450 activity by stiripentol.
Biochemical pharmacology 1988;37(19):3619-22.
1988: M Mesnil; Bernard Testa; Peter Jenner
In vitro inhibition by stiripentol of rat brain cytochrome P-450-mediated naphthalene hydroxylation.
Xenobiotica; the fate of foreign compounds in biological systems 1988;18(9):1097-106.
1988: N el Tayar; Bernard Testa; H van de Waterbeemd; Pierre-Alain Carrupt; A J Kaumann
Influence of lipophilicity and chirality on the selectivity of ligands for beta 1- and beta 2-adrenoceptors.
The Journal of pharmacy and pharmacology 1988;40(9):609-12.
1988: S Beyeler; Bernard Testa; D Perrissoud
Flavonoids as inhibitors of rat liver monooxygenase activities.
Biochemical pharmacology 1988;37(10):1971-9.
1988: Joachim M Mayer; C Bartolucci; J M Maître; Bernard Testa
Metabolic chiral inversion of anti-inflammatory 2-arylpropionates: lack of reaction in liver homogenates, and study of methine proton acidity.
Xenobiotica; the fate of foreign compounds in biological systems 1988;18(5):533-43.
1988: Bernard Testa
Substrate and product stereoselectivity in monooxygenase-mediated drug activation and inactivation.
Biochemical pharmacology 1988;37(1):85-92.
1987: H Van de Waterbeemd; Bernard Testa; C Marrel; D R Cooper; Peter Jenner; CD Marsden
Multivariate statistical analysis of L-dopa esters as potential anti-parkinsonian prodrugs.
Drug design and delivery 1987;2(2):135-43.
1987: Bernard Testa; Peter Jenner; G J Kilpatrick; N el Tayar; H Van de Waterbeemd; CD Marsden
Do thermodynamic studies provide information on both the binding to and the activation of dopaminergic and other receptors?
Biochemical pharmacology 1987;36(23):4041-6.
1987: H Van de Waterbeemd; N el Tayar; Bernard Testa; H Wikström; B Largent
Quantitative structure-activity relationships and eudismic analyses of the presynaptic dopaminergic activity and dopamine D2 and sigma receptor affinities of 3-(3-hydroxyphenyl)piperidines and octahydrobenzo[f]quinolines.
Journal of medicinal chemistry 1987;30(12):2175-81.
1987: D R Cooper; C Marrel; H van de Waterbeemd; Bernard Testa; Peter Jenner; CD Marsden
L-dopa esters as potential prodrugs: effect on brain concentration of dopamine metabolites in reserpinized mice.
The Journal of pharmacy and pharmacology 1987;39(10):809-18.
1987: Bernard Testa; N el Tayar; Pierre-Alain Carrupt; H Van de Waterbeemd; G J Kilpatrick; Peter Jenner; CD Marsden
The influence of aromatic substituents on the binding of substituted benzamides to dopamine D-2 receptors: congruent QSAR and MEP analyses.
The Journal of pharmacy and pharmacology 1987;39(9):767-8.
1987: D R Cooper; C Marrel; H van de Waterbeemd; Bernard Testa; Peter Jenner; CD Marsden
L-dopa esters as potential prodrugs: behavioural activity in experimental models of Parkinson's disease.
The Journal of pharmacy and pharmacology 1987;39(8):627-35.
1986: G J Kilpatrick; N el Tayar; H Van de Waterbeemd; Peter Jenner; Bernard Testa; CD Marsden
The thermodynamics of agonist and antagonist binding to dopamine D-2 receptors.
Molecular pharmacology 1986;30(3):226-34.
1986: H van de Waterbeemd; Pierre-Alain Carrupt; Bernard Testa
Molecular electrostatic potential of orthopramides: implications for their interaction with the D-2 dopamine receptor.
Journal of medicinal chemistry 1986;29(5):600-6.
1986: F Bree; N el Tayar; H Van de Waterbeemd; Bernard Testa; J P Tillement
The binding of agonists and antagonists to rat lung beta-adrenergic receptors as investigated by thermodynamics and structure-activity relationships.
Journal of receptor research 1986;6(5-6):381-409.
1984: D R Cooper; C Marrel; Bernard Testa; H van de Waterbeemd; Niall Quinn; Peter Jenner; CD Marsden
L-Dopa methyl ester--a candidate for chronic systemic delivery of L-Dopa in Parkinson's disease.
Clinical neuropharmacology 1984;7(1):89-98.
1983: S Beyeler; Bernard Testa; D Perrissoud
The effect of cianidanol on rat hepatic monooxygenase activities.
Arzneimittel-Forschung 1983;33(4):564-7.