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Kenneth Tew

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
29
Townsend, Danyelle
19
Tapiero, Haim
12
Shen, Hongxie
11
Davis, Warren
11
Gaté, Laurent
8
Chen, Zhijian
7
Clapper, Margie
7
Ile, Kristina
7
Kruh, Gary
6
Ronai, Ze'ev
6
Ranganathan, S
6
Findlay, Victoria
5
Soulika, Athena
5
O'Dwyer, Peter
5
Hudes, Gary

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Publications

TOP 3
Townsend Danyelle M; Manevich Yefim; He Lin; Xiong Ying; Bowers Robert R; Hutchens Steven; Tew Kenneth D
Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response.
Townsend Danyelle M; Tew Kenneth D
Pharmacology of a mimetic of glutathione disulfide, NOV-002.
Townsend Danyelle M; Tew Kenneth D; He Lin; King Jarrod B; Hanigan Marie H
Role of glutathione S-transferase Pi in cisplatin-induced nephrotoxicity.

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All Publications

2009: Townsend Danyelle M; Manevich Yefim; He Lin; Xiong Ying; Bowers Robert R; Hutchens Steven; Tew Kenneth D
Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response.
Cancer research 2009;69(19):7626-34.
2009: Townsend Danyelle M; Tew Kenneth D
Pharmacology of a mimetic of glutathione disulfide, NOV-002.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2009;63(2):75-8.
2009: Townsend Danyelle M; Tew Kenneth D; He Lin; King Jarrod B; Hanigan Marie H
Role of glutathione S-transferase Pi in cisplatin-induced nephrotoxicity.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2009;63(2):79-85.
2009: Townsend Danyelle M; Manevich Yefim; He Lin; Hutchens Steven; Pazoles Christopher J; Tew Kenneth D
Novel role for glutathione S-transferase pi. Regulator of protein S-Glutathionylation following oxidative and nitrosative stress.
The Journal of biological chemistry 2009;284(1):436-45.
2008: Lei K; Townsend D M; Tew K D
Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response.
Oncogene 2008;27(36):4877-87.
2008: Townsend Danyelle M; Pazoles Christopher J; Tew Kenneth D
NOV-002, a mimetic of glutathione disulfide.
Expert opinion on investigational drugs 2008;17(7):1075-83.
2008: Townsend Danyelle M; He Lin; Hutchens Steven; Garrett Tracy E; Pazoles Christopher J; Tew Kenneth D
NOV-002, a glutathione disulfide mimetic, as a modulator of cellular redox balance.
Cancer research 2008;68(8):2870-7.
2008: Mack Jody T; Brown Carol B; Tew Kenneth D
ABCA2 as a therapeutic target in cancer and nervous system disorders.
Expert opinion on therapeutic targets 2008;12(4):491-504.
2007: Tew Kenneth D
Redox in redux: Emergent roles for glutathione S-transferase P (GSTP) in regulation of cell signaling and S-glutathionylation.
Biochemical pharmacology 2007;73(9):1257-69.
2007: Mack Jody T; Townsend Danyelle M; Beljanski Vladimir; Tew Kenneth D
The ABCA2 transporter: intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds.
Current drug metabolism 2007;8(1):47-57.
2007: Mack Jody T; Beljanski Vladimir; Soulika Athena M; Townsend Danyelle M; Brown Carol B; Davis Warren; Tew Kenneth D
"Skittish" Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system.
Molecular and cellular biology 2007;27(1):44-53.
2006: Tew Kenneth D
How is a conservative US administration influencing NCI funding?
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2006;60(9):500-1.
2006: Mack J T; Beljanski V; Tew K D; Townsend D M
The ATP-binding cassette transporter ABCA2 as a mediator of intracellular trafficking.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2006;60(9):587-92.
2006: Findlay Victoria J; Townsend Danyelle M; Morris Taylor E; Fraser Jacob P; He Lin; Tew Kenneth D
A novel role for human sulfiredoxin in the reversal of glutathionylation.
Cancer research 2006;66(13):6800-6.
2006: McIlwain C C; Townsend D M; Tew K D
Glutathione S-transferase polymorphisms: cancer incidence and therapy.
Oncogene 2006;25(11):1639-48.
2006: Saavedra Joseph E; Srinivasan Aloka; Buzard Gregory S; Davies Keith M; Waterhouse David J; Inami Keiko; Wilde Thomas C; Citro Michael L; Cuellar Matthew; Deschamps Jeffrey R; Parrish Damon; Shami Paul J; Findlay Victoria J; Townsend Danyelle M; Tew Kenneth D; Singh Shivendra; Jia Lee; Ji Xinhua; Keefer Larry K
PABA/NO as an anticancer lead: analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity.
Journal of medicinal chemistry 2006;49(3):1157-64.
2006: Townsend Danyelle M; Findlay Victoria J; Fazilev Farit; Ogle Molly; Fraser Jacob; Saavedra Joseph E; Ji Xinhua; Keefer Larry K; Tew Kenneth D
A glutathione S-transferase pi-activated prodrug causes kinase activation concurrent with S-glutathionylation of proteins.
Molecular pharmacology 2006;69(2):501-8.
2005: Tucker Jody M; Lipatova Zhanna; Beljanski Vladimir; Townsend Danyelle M; Tew Kenneth D
Evaluation of lipophilins as determinants of tumor cell response to estramustine.
The Journal of pharmacology and experimental therapeutics 2005;315(3):1158-62.
2005: Tew Kenneth D
TLK-286: a novel glutathione S-transferase-activated prodrug.
Expert opinion on investigational drugs 2005;14(8):1047-54.
2005: Beljanski Vladimir; Soulika Athena; Tucker Jody M; Townsend Danyelle M; Davis Warren; Tew Kenneth D
Characterization of the ATPase activity of human ATP-binding cassette transporter-2 (ABCA2).
In vivo (Athens, Greece) 2005;19(4):657-60.
2005: Gate Laurent; Majumdar Rajrupa S; Lunk Alexandra; Tew Kenneth D
Influence of glutathione S-transferase pi and p53 expression on tumor frequency and spectrum in mice.
International journal of cancer. Journal international du cancer 2005;113(1):29-35.
2005: Townsend Danyelle M; Findlay Victoria L; Tew Kenneth D
Glutathione S-transferases as regulators of kinase pathways and anticancer drug targets.
Methods in enzymology 2005;401():287-307.
2004: Tew Kenneth D; Boyd Jonathan T; Chen Zhijian J; Davis Warren; Fazilev Farit; Findlay Victoria; Gaté Laurent; Ile Kristina; Soulika Athena; Townsend Danyelle M
Glutathione and ABC transporters as determinants of sensitivity to oxidative and nitrosative stress.
The Journal of nutrition 2004;134(11):3205S-3206S.
2004: Davis Warren; Boyd Jonathan T; Ile Kristina E; Tew Kenneth D
Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density lipoprotein receptor expression and negatively regulates cholesterol esterification in Chinese hamster ovary cells.
Biochimica et biophysica acta 2004;1683(1-3):89-100.
2004: Chen Zhijian J; Vulevic Bojana; Ile Kristina E; Soulika Athena; Davis Warren; Reiner Peter B; Connop Bruce P; Nathwani Parimal; Trojanowski John Q; Tew Kenneth D
Association of ABCA2 expression with determinants of Alzheimer's disease.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(10):1129-31.
2004: Boonstra R; Timmer-Bosscha H; van Echten-Arends J; van der Kolk D M; van den Berg A; de Jong B; Tew K D; Poppema S; de Vries E G E
Mitoxantrone resistance in a small cell lung cancer cell line is associated with ABCA2 upregulation.
British journal of cancer 2004;90(12):2411-7.
2004: Findlay Victoria J; Townsend Danyelle M; Saavedra Joseph E; Buzard Gregory S; Citro Michael L; Keefer Larry K; Ji Xinhua; Tew Kenneth D
Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug.
Molecular pharmacology 2004;65(5):1070-9.
2004: Tapiero Haim; Townsend Danyelle M; Tew Kenneth D
Organosulfur compounds from alliaceae in the prevention of human pathologies.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2004;58(3):183-93.
2004: Ile Kristina E; Davis Warren; Boyd Jonathan T; Soulika Athena M; Tew Kenneth D
Identification of a novel first exon of the human ABCA2 transporter gene encoding a unique N-terminus.
Biochimica et biophysica acta 2004;1678(1):22-32.
2004: Tew Kenneth D
Small molecule inhibition of hypoxia inducible factor-1alpha: a viable therapeutic approach?
Molecular cancer therapeutics 2004;3(3):245-6.
2004: Tapiero H; Townsend D M; Tew K D
The role of carotenoids in the prevention of human pathologies.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2004;58(2):100-10.
2004: Gate Laurent; Majumdar Rajrupa S; Lunk Alexandra; Tew Kenneth D
Increased myeloproliferation in glutathione S-transferase pi-deficient mice is associated with a deregulation of JNK and Janus kinase/STAT pathways.
The Journal of biological chemistry 2004;279(10):8608-16.
2004: Townsend Danyelle M; Tew Kenneth D; Tapiero Haim
Sulfur containing amino acids and human disease.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2004;58(1):47-55.
2004: Chen Zhijian J; Tew Kenneth D
Amplified differential gene expression microarray.
Methods in molecular biology (Clifton, N.J.) 2004;258():95-106.
2003: Tapiero Haim; Tew Kenneth D
Trace elements in human physiology and pathology: zinc and metallothioneins.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2003;57(9):399-411.
2003: Tapiero H; Townsend D M; Tew K D
Trace elements in human physiology and pathology. Copper.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2003;57(9):386-98.
2003: Townsend Danyelle M; Tew Kenneth D
The role of glutathione-S-transferase in anti-cancer drug resistance.
Oncogene 2003;22(47):7369-75.
2003: Tapiero H; Townsend D M; Tew K D
Phytosterols in the prevention of human pathologies.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2003;57(8):321-5.
2003: Efferth Thomas; Sauerbrey Axel; Olbrich Armin; Gebhart Erich; Rauch Pia; Weber H Oliver; Hengstler Jan G; Halatsch Marc-Eric; Volm Manfred; Tew Kenneth D; Ross Douglas D; Funk Jens Oliver
Molecular modes of action of artesunate in tumor cell lines.
Molecular pharmacology 2003;64(2):382-94.
2003: Chen Zhijian J; Gaté Laurent; Davis Warren; Ile Kristina E; Tew Kenneth D
Sensitivity and fidelity of DNA microarray improved with integration of Amplified Differential Gene Expression (ADGE).
BMC genomics 2003;4(1):28.
2003: Townsend Danyelle M; Tew Kenneth D; Tapiero Haim
The importance of glutathione in human disease.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2003;57(3-4):145-55.
2003: Tapiero H; Townsend D M; Tew K D
The antioxidant role of selenium and seleno-compounds.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2003;57(3-4):134-44.
2003: Gaté Laurent; Lunk Alexandra; Tew Kenneth D
Resistance to phorbol 12-myristate 13-acetate-induced cell growth arrest in an HL60 cell line chronically exposed to a glutathione S-transferase pi inhibitor.
Biochemical pharmacology 2003;65(10):1611-22.
2003: Davis Warren; Chen Zhijian J; Ile Kristina E; Tew Kenneth D
Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors.
Nucleic acids research 2003;31(3):1097-107.
2003: Townsend Danyelle; Tew Kenneth
Cancer drugs, genetic variation and the glutathione-S-transferase gene family.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 2003;3(3):157-72.
2002: Chen Zhijian J; Gaté Laurent; Davis Warren; Ile Kristina E; Tew Kenneth D
Integration of amplified differential gene expression (ADGE) and DNA microarray.
IUBMB life 2002;54(6):335-8.
2002: Tapiero H; Mathé G; Couvreur P; Tew K D
II. Glutamine and glutamate.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2002;56(9):446-57.
2002: Tapiero H; Mathé G; Couvreur P; Tew K D
I. Arginine.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2002;56(9):439-45.
2002: Townsend Danyelle M; Shen Hongxie; Staros Alexandra L; Gaté Laurent; Tew Kenneth D
Efficacy of a glutathione S-transferase pi-activated prodrug in platinum-resistant ovarian cancer cells.
Molecular cancer therapeutics 2002;1(12):1089-95.
2002: Tapiero H; Ba G Nguyen; Couvreur P; Tew K D
Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2002;56(5):215-22.
2002: Tapiero H; Tew K D; Ba G Nguyen; Mathé G
Polyphenols: do they play a role in the prevention of human pathologies?
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2002;56(4):200-7.
2002: Golemis Erica A; Tew Kenneth D; Dadke Disha
Protein interaction-targeted drug discovery: evaluating critical issues.
BioTechniques 2002;32(3):636-8, 640, 642 passim.
2002: Tapiero H; Ba G Nguyen; Tew K D
Estrogens and environmental estrogens.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2002;56(1):36-44.
2001: Tapiero H; Tew K D; Gaté L; Machover D
Prevention of pathologies associated with oxidative stress and dietary intake deficiencies: folate deficiency and requirements.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2001;55(7):381-90.
2001: Tapiero H; Gaté L; Tew K D
Iron: deficiencies and requirements.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2001;55(6):324-32.
2001: Ruscoe J E; Rosario L A; Wang T; Gaté L; Arifoglu P; Wolf C R; Henderson C J; Ronai Z; Tew K D
Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways.
The Journal of pharmacology and experimental therapeutics 2001;298(1):339-45.
2001: Shen H; Chen Z J; Zilfou J T; Hopper E; Murphy M; Tew K D
Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs.
The Journal of pharmacology and experimental therapeutics 2001;297(3):1067-73.
2001: Wang T; Arifoglu P; Ronai Z; Tew K D
Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus.
The Journal of biological chemistry 2001;276(24):20999-1003.
2001: Chen Z J; Shen H; Tew K D
Gene expression profiling using a novel method: amplified differential gene expression (ADGE).
Nucleic acids research 2001;29(10):E46.
2001: Vulevic B; Chen Z; Boyd J T; Davis W; Walsh E S; Belinsky M G; Tew K D
Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2).
Cancer research 2001;61(8):3339-47.
2001: Davis W; Ronai Z; Tew K D
Cellular thiols and reactive oxygen species in drug-induced apoptosis.
The Journal of pharmacology and experimental therapeutics 2001;296(1):1-6.
2000: Yin Z; Ivanov V N; Habelhah H; Tew K; Ronai Z
Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases.
Cancer research 2000;60(15):4053-7.
2000: O'Brien M; Kruh G D; Tew K D
The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance.
The Journal of pharmacology and experimental therapeutics 2000;294(2):480-7.
2000: Rosario L A; O'Brien M L; Henderson C J; Wolf C R; Tew K D
Cellular response to a glutathione S-transferase P1-1 activated prodrug.
Molecular pharmacology 2000;58(1):167-74.
1999: O'Brien M L; Vulevic B; Freer S; Boyd J; Shen H; Tew K D
Glutathione peptidomimetic drug modulator of multidrug resistance-associated protein.
The Journal of pharmacology and experimental therapeutics 1999;291(3):1348-55.
1999: Ranganathan S; Ciaccio P J; Walsh E S; Tew K D
Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation.
Gene 1999;240(1):149-55.
1999: Adler V; Yin Z; Tew K D; Ronai Z
Role of redox potential and reactive oxygen species in stress signaling.
Oncogene 1999;18(45):6104-11.
1999: Shen H; Schultz M P; Tew K D
Glutathione conjugate interactions with DNA-dependent protein kinase.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1101-6.
1999: Gaté L; Paul J; Ba G N; Tew K D; Tapiero H
Oxidative stress induced in pathologies: the role of antioxidants.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1999;53(4):169-80.
1999: Adler V; Yin Z; Fuchs S Y; Benezra M; Rosario L; Tew K D; Pincus M R; Sardana M; Henderson C J; Wolf C R; Davis R J; Ronai Z
Regulation of JNK signaling by GSTp.
The EMBO journal 1999;18(5):1321-34.
1998: Sangrajrang S; Denoulet P; Millot G; Tatoud R; Podgorniak M P; Tew K D; Calvo F; Fellous A
Estramustine resistance correlates with tau over-expression in human prostatic carcinoma cells.
International journal of cancer. Journal international du cancer 1998;77(4):626-31.
1998: Shen H; Schultz M; Kruh G D; Tew K D
Increased expression of DNA-dependent protein kinase confers resistance to adriamycin.
Biochimica et biophysica acta 1998;1381(2):131-8.
1998: Morgan A S; Sanderson P E; Borch R F; Tew K D; Niitsu Y; Takayama T; Von Hoff D D; Izbicka E; Mangold G; Paul C; Broberg U; Mannervik B; Henner W D; Kauvar L M
Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione S-transferase.
Cancer research 1998;58(12):2568-75.
1998: Tapiero H; Gaté L; Dhalluin S; Nguyen Ba G; Soupramanien V; Kouyate J; Tew K D
The antioxidant effects of Crassostrea gigas extract (JCOE) in human volunteers.
In vivo (Athens, Greece) 1998;12(3):305-9.
1998: Gaté L; Schultz M; Walsh E; Dhalluin S; Nguyen Ba G; Tapiero H; Tew K D
Impact of dietary supplement of Crassostrea gigas extract (JCOE) on glutathione levels and glutathione S-transferase activity in rat tissues.
In vivo (Athens, Greece) 1998;12(3):299-303.
1998: Tew K D; O'Brien M; Laing N M; Shen H
Coordinate changes in expression of protective genes in drug-resistant cells.
Chemico-biological interactions 1998;111-112():199-211.
1998: Laing N M; Belinsky M G; Kruh G D; Bell D W; Boyd J T; Barone L; Testa J R; Tew K D
Amplification of the ATP-binding cassette 2 transporter gene is functionally linked with enhanced efflux of estramustine in ovarian carcinoma cells.
Cancer research 1998;58(7):1332-7.
1998: Sangrajrang S; Denoulet P; Laing N M; Tatoud R; Millot G; Calvo F; Tew K D; Fellous A
Association of estramustine resistance in human prostatic carcinoma cells with modified patterns of tubulin expression.
Biochemical pharmacology 1998;55(3):325-31.
1997: Paul S; Breuninger L M; Tew K D; Shen H; Kruh G D
ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14976.
1997: Laing N; Dahllöf B; Hartley-Asp B; Ranganathan S; Tew K D
Interaction of estramustine with tubulin isotypes.
Biochemistry 1997;36(4):871-8.
1997: Shen H; Kauvar L; Tew K D
Importance of glutathione and associated enzymes in drug response.
Oncology research 1997;9(6-7):295-302.
1996: Ciaccio P J; Walsh E S; Tew K D
Promoter analysis of a human dihydrodiol dehydrogenase.
Biochemical and biophysical research communications 1996;228(2):524-9.
1996: Ciaccio P J; Tew K D
Adaptive response to glutathione S-transferase inhibitors.
The British journal of cancer. Supplement 1996;27():S93-8.
1996: Tew K D; Monks A; Barone L; Rosser D; Akerman G; Montali J A; Wheatley J B; Schmidt D E
Glutathione-associated enzymes in the human cell lines of the National Cancer Institute Drug Screening Program.
Molecular pharmacology 1996;50(1):149-59.
1996: Paul S; Breuninger L M; Tew K D; Shen H; Kruh G D
ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):6929-34.
1996: O'Brien M L; Tew K D
Glutathione and related enzymes in multidrug resistance.
European journal of cancer (Oxford, England : 1990) 1996;32A(6):967-78.
1996: Ranganathan S; Dexter D W; Benetatos C A; Chapman A E; Tew K D; Hudes G R
Increase of beta(III)- and beta(IVa)-tubulin isotopes in human prostate carcinoma cells as a result of estramustine resistance.
Cancer research 1996;56(11):2584-9.
1996: Shen H; Paul S; Breuninger L M; Ciaccio P J; Laing N M; Helt M; Tew K D; Kruh G D
Cellular and in vitro transport of glutathione conjugates by MRP.
Biochemistry 1996;35(18):5719-25.
1996: Ciaccio P J; Shen H; Kruh G D; Tew K D
Effects of chronic ethacrynic acid exposure on glutathione conjugation and MRP expression in human colon tumor cells.
Biochemical and biophysical research communications 1996;222(1):111-5.
1996: Raha A; Tew K D
Glutathione S-transferases.
Cancer treatment and research 1996;87():83-122.
1996: Tapiero H; Tew K D
Increased glutathione expression in cells induced by Crassostera gigas extract (JCOE).
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1996;50(3-4):149-53.
1996: Schröder C P; Godwin A K; O'Dwyer P J; Tew K D; Hamilton T C; Ozols R F
Glutathione and drug resistance.
Cancer investigation 1996;14(2):158-68.
1996: Morgan A S; Ciaccio P J; Tew K D; Kauvar L M
Isozyme-specific glutathione S-transferase inhibitors potentiate drug sensitivity in cultured human tumor cell lines.
Cancer chemotherapy and pharmacology 1996;37(4):363-70.
1995: Shen H; Ranganathan S; Kuzmich S; Tew K D
Influence of ethacrynic acid on glutathione S-transferase pi transcript and protein half-lives in human colon cancer cells.
Biochemical pharmacology 1995;50(8):1233-8.
1995: Ciaccio P J; Shen H; Jaiswal A K; Lyttle M H; Tew K D
Modulation of detoxification gene expression in human colon HT29 cells by glutathione-S-transferase inhibitors.
Molecular pharmacology 1995;48(4):639-47.
1995: Ranganathan S; Walsh E S; Tew K D
Glyoxalase I in detoxification: studies using a glyoxalase I transfectant cell line.
The Biochemical journal 1995;309 ( Pt 1)():127-31.
1995: Smith C D; Zilfou J T; Zhang X; Hudes G R; Tew K D
Modulation of P-glycoprotein activity by estramustine is limited by binding to plasma proteins.
Cancer 1995;75(10):2597-604.
1995: O'Dwyer P J; Hamilton T C; Yao K S; Tew K D; Ozols R F
Modulation of glutathione and related enzymes in reversal of resistance to anticancer drugs.
Hematology/oncology clinics of North America 1995;9(2):383-96.
1994: Speicher L A; Laing N; Barone L R; Robbins J D; Seamon K B; Tew K D
Interaction of an estramustine photoaffinity analogue with cytoskeletal proteins in prostate carcinoma cells.
Molecular pharmacology 1994;46(5):866-72.
1994: Lacreta F P; Brennan J M; Nash S L; Comis R L; Tew K D; O'Dwyer P J
Pharmakokinetics and bioavailability study of ethacrynic acid as a modulator of drug resistance in patients with cancer.
The Journal of pharmacology and experimental therapeutics 1994;270(3):1186-91.
1994: Tew K D
Glutathione-associated enzymes in anticancer drug resistance.
Cancer research 1994;54(16):4313-20.
1994: Ciaccio P J; Tew K D
cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.
Biochimica et biophysica acta 1994;1186(1-2):129-32.
1994: Ciaccio P J; Jaiswal A K; Tew K D
Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics.
The Journal of biological chemistry 1994;269(22):15558-62.
1994: Speicher L A; Barone L R; Chapman A E; Hudes G R; Laing N; Smith C D; Tew K D
P-glycoprotein binding and modulation of the multidrug-resistant phenotype by estramustine.
Journal of the National Cancer Institute 1994;86(9):688-94.
1993: Ranganathan S; Tew K D
Analysis of glyoxalase-I from normal and tumor tissue from human colon.
Biochimica et biophysica acta 1993;1182(3):311-6.
1993: Ciaccio P J; Stuart J E; Tew K D
Overproduction of a 37.5-kDa cytosolic protein structurally related to prostaglandin F synthase in ethacrynic acid-resistant human colon cells.
Molecular pharmacology 1993;43(6):845-53.
1993: Ranganathan S; Walsh E S; Godwin A K; Tew K D
Cloning and characterization of human colon glyoxalase-I.
The Journal of biological chemistry 1993;268(8):5661-7.
1993: Clapper M L; Kuzmich S; Seestaller L M; Tew K D
Time course of glutathione S-transferase elevation in Walker mammary carcinoma cells following chlorambucil exposure.
Biochemical pharmacology 1993;45(3):683-90.
1992: Tew K D; Glusker J P; Hartley-Asp B; Hudes G; Speicher L A
Preclinical and clinical perspectives on the use of estramustine as an antimitotic drug.
Pharmacology & therapeutics 1992;56(3):323-39.
1992: Hudes G R; Greenberg R; Krigel R L; Fox S; Scher R; Litwin S; Watts P; Speicher L; Tew K; Comis R
Phase II study of estramustine and vinblastine, two microtubule inhibitors, in hormone-refractory prostate cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1992;10(11):1754-61.
1992: Speicher L A; Barone L; Tew K D
Combined antimicrotubule activity of estramustine and taxol in human prostatic carcinoma cell lines.
Cancer research 1992;52(16):4433-40.
1992: Schisselbauer J C; Hogan W M; Buetow K H; Tew K D
Heterogeneity of glutathione S-transferase enzyme and gene expression in ovarian carcinoma.
Pharmacogenetics 1992;2(2):63-72.
1992: Punzi J S; Duax W L; Strong P; Griffin J F; Flocco M M; Zacharias D E; Carrell H L; Tew K D; Glusker J P
Molecular conformation of estramustine and two analogues.
Molecular pharmacology 1992;41(3):569-76.
1992: O'Dwyer P J; Hamilton T C; Young R C; LaCreta F P; Carp N; Tew K D; Padavic K; Comis R L; Ozols R F
Depletion of glutathione in normal and malignant human cells in vivo by buthionine sulfoximine: clinical and biochemical results.
Journal of the National Cancer Institute 1992;84(4):264-7.
1992: Kuzmich S; Vanderveer L A; Walsh E S; LaCreta F P; Tew K D
Increased levels of glutathione S-transferase pi transcript as a mechanism of resistance to ethacrynic acid.
The Biochemical journal 1992;281 ( Pt 1)():219-24.
1991: Ranganathan S; Tew K D
Immunohistochemical localization of glutathione S-transferases alpha, mu, and pi in normal tissue and carcinomas from human colon.
Carcinogenesis 1991;12(12):2383-7.
1991: O'Dwyer P J; LaCreta F; Nash S; Tinsley P W; Schilder R; Clapper M L; Tew K D; Panting L; Litwin S; Comis R L
Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid.
Cancer research 1991;51(22):6059-65.
1991: Clapper M L; Hoffman S J; Carp N; Watts P; Seestaller L M; Weese J L; Tew K D
Contribution of patient history to the glutathione S-transferase activity of human lung, breast and colon tissue.
Carcinogenesis 1991;12(10):1957-61.
1991: Ciaccio P J; Tew K D; LaCreta F P
Enzymatic conjugation of chlorambucil with glutathione by human glutathione S-transferases and inhibition by ethacrynic acid.
Biochemical pharmacology 1991;42(7):1504-7.
1991: Speicher L A; Sheridan V R; Godwin A K; Tew K D
Resistance to the antimitotic drug estramustine is distinct from the multidrug resistant phenotype.
British journal of cancer 1991;64(2):267-73.
1991: Morris D I; Speicher L A; Ruoho A E; Tew K D; Seamon K B
Interaction of forskolin with the P-glycoprotein multidrug transporter.
Biochemistry 1991;30(34):8371-9.
1991: Kuzmich S; Vanderveer L A; Tew K D
Evidence for a glycoconjugate form of glutathione S-transferase pI.
International journal of peptide and protein research 1991;37(6):565-71.
1991: Clapper M L; Hoffman S J; Tew K D
Glutathione S-transferases in normal and malignant human colon tissue.
Biochimica et biophysica acta 1991;1096(3):209-16.
1991: Sheridan V R; Speicher L A; Tew K D
The effects of estramustine on metaphase and anaphase in DU 145 prostatic carcinoma cells.
European journal of cell biology 1991;54(2):268-76.
1991: Kuzmich S; Tew K D
Detoxification mechanisms and tumor cell resistance to anticancer drugs.
Medicinal research reviews 1991;11(2):185-217.
1991: Sheridan V R; Tew K D
Mechanism based chemotherapy for prostate cancer.
Cancer surveys 1991;11():239-54.
1990: Schisselbauer J C; Silber R; Papadopoulos E; Abrams K; LaCreta F P; Tew K D
Characterization of glutathione S-transferase expression in lymphocytes from chronic lymphocytic leukemia patients.
Cancer research 1990;50(12):3562-8.
1990: Fujiwara Y; Sugimoto Y; Kasahara K; Bungo M; Yamakido M; Tew K D; Saijo N
Determinants of drug response in a cisplatin-resistant human lung cancer cell line.
Japanese journal of cancer research : Gann 1990;81(5):527-35.
1990: Nakagawa K; Saijo N; Tsuchida S; Sakai M; Tsunokawa Y; Yokota J; Muramatsu M; Sato K; Terada M; Tew K D
Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines.
The Journal of biological chemistry 1990;265(8):4296-301.
1990: Ciaccio P J; Tew K D; LaCreta F P
The spontaneous and glutathione S-transferase-mediated reaction of chlorambucil with glutathione.
Cancer communications 1990;2(8):279-85.
1989: Tapiero H; Yin M B; Catalin J; Paraire M; Deloffre P; Rustum Y; Bizzari J P; Tew K D
Cytotoxicity and DNA damaging effects of a new nitrosourea, fotemustine, diethyl- 1-(3-(2-chloroethyl)-3-nitrosoureido) ethylphosphonate-S10036.
Anticancer research 1989;9(6):1617-22.
1989: Clapper M L; Tew K D
Identification of a glutathione S-transferase associated with microsomes of tumor cells resistant to nitrogen mustards.
Biochemical pharmacology 1989;38(12):1915-21.
1989: Tew K D; Stearns M E
Estramustine--a nitrogen mustard/steroid with antimicrotubule activity.
Pharmacology & therapeutics 1989;43(3):299-319.
1989: Tew K D; Stearns M E
Intracellular effects of estramustine (Estracyt/Emcyt).
Progress in clinical and biological research 1989;303():169-75.
1989: Schisselbauer J C; Crescimanno M; D'Alessandro N; Clapper M; Toulmond S; Tapiero H; Tew K D
Glutathione, glutathione S-transferases, and related redox enzymes in Adriamycin-resistant cell lines with a multidrug resistant phenotype.
Cancer communications 1989;1(2):133-9.
1989: Clapper M L; Tew K D
Alkylating agent resistance.
Cancer treatment and research 1989;48():125-50.
1988: LaCreta F P; Olszewski J J; Tew K D
Purification of glutathione S-transferases from rat liver and Walker 256 mammary carcinoma cells by high-performance liquid chromatography and a glutathione affinity column.
Journal of chromatography 1988;434(1):83-93.
1988: Stearns M E; Wang M; Tew K D; Binder L I
Estramustine binds a MAP-1-like protein to inhibit microtubule assembly in vitro and disrupt microtubule organization in DU 145 cells.
The Journal of cell biology 1988;107(6 Pt 2):2647-56.
1988: Tew K D; Bomber A M; Hoffman S J
Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines.
Cancer research 1988;48(13):3622-5.
1988: Stearns M E; Tew K D
Estramustine binds MAP-2 to inhibit microtubule assembly in vitro.
Journal of cell science 1988;89 ( Pt 3)():331-42.
1987: Wang M; Tew K D; Stearns M E
Immunofluorescent studies of the anti-microtubule effects of the anti-cancer drug estramustine.
Anticancer research 1987;7(6):1165-71.
1987: Tew K D; Clapper M L; Greenberg R E; Weese J L; Hoffman S J; Smith T M
Glutathione S-transferases in human prostate.
Biochimica et biophysica acta 1987;926(1):8-15.
1987: Buller A L; Clapper M L; Tew K D
Glutathione S-transferases in nitrogen mustard-resistant and -sensitive cell lines.
Molecular pharmacology 1987;31(6):575-8.
1987: Hartley-Asp B; Billström A; Tew K D
C-banding of two Walker 256 rat carcinoma cell lines sensitive and resistant to bifunctional mustards.
Anticancer research 1987;7(2):209-13.
1987: Tew K D; Stearns M E
Hormone-independent, non-alkylating mechanism of cytotoxicity for estramustine.
Urological research 1987;15(3):155-60.
1987: Tew K D; Dean S W; Gibson N W
The effect of a novel taurine nitrosourea, 1-(2-chloroethyl)-3-[2-(dimethylaminosulfonyl)ethyl]-1-nitrosour ea (TCNU) on cytotoxicity, DNA crosslinking and glutathione reductase in lung carcinoma cell lines.
Cancer chemotherapy and pharmacology 1987;19(4):291-5.
1986: Moy B C; Tew K D
Differences in the nuclear matrix phosphoproteins of a wild-type and nitrogen mustard-resistant rat breast carcinoma cell line.
Cancer research 1986;46(9):4672-6.
1986: Dean S W; Gibson N W; Tew K D
Selection of nitrogen mustard resistance in a rat tumor cell line results in loss of guanine-O6-alkyl transferase activity.
Molecular pharmacology 1986;30(1):77-80.
1986: Tew K D; Woodworth A; Stearns M E
Relationship of glutathione depletion and inhibition of glutathione-S-transferase activity to the antimitotic properties of estramustine.
Cancer treatment reports 1986;70(6):715-20.
1986: Dean S W; Johnson A B; Tew K D
A comparative analysis of drug-induced DNA effects in a nitrogen mustard resistant cell line expressing sensitivity to nitrosoureas.
Biochemical pharmacology 1986;35(7):1171-6.
1985: Stearns M E; Jenkins D P; Tew K D
Dansylated estramustine, a fluorescent probe for studies of estramustine uptake and identification of intracellular targets.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(24):8483-7.
1985: Dean S W; Tew K D; Clark A E; Schein P S
DNA repeat length in chromatin from murine bone marrow and L1210 leukaemia cells.
British journal of cancer 1985;52(3):377-82.
1985: Stearns M E; Tew K D
Antimicrotubule effects of estramustine, an antiprostatic tumor drug.
Cancer research 1985;45(8):3891-7.
1985: Moy B C; Tew K D
Poly(adenosine diphosphate-ribosylation) of nuclear matrix proteins in alkylating agent resistant and sensitive cell lines.
Chemico-biological interactions 1985;54(2):209-22.
1985: Wang A L; Tew K D
Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards.
Cancer treatment reports 1985;69(6):677-82.
1985: Tew K D; Kyle G; Johnson A; Wang A L
Carbamoylation of glutathione reductase and changes in cellular and chromosome morphology in a rat cell line resistant to nitrogen mustards but collaterally sensitive to nitrosoureas.
Cancer research 1985;45(5):2326-33.
1985: Lown J W; Koganty R R; Tew K D; Oiry J; Imbach J L
Mechanism of action of 2-haloethylnitrosoureas on deoxyribonucleic acid. Pathways of aqueous decomposition and pharmacological characteristics of new anticancer disulfide-linked nitrosoureas.
Biochemical pharmacology 1985;34(7):1015-24.
1985: Vu V T; Moy B C; Schein P S; Tew K D
Enhanced nitrosourea cytotoxicity in cell culture by sodium butyrate.
Oncology 1985;42(5):317-21.
1984: Farhi J J; Bennoun M; Tapiero H; Wang A L; Tew K D
Biochemical and cytotoxic properties of the isomeric forms of N,N'-bis[N-2-chloroethyl)-N-nitrosocarbamoyl] cystamine.
Biochemical pharmacology 1984;33(16):2575-80.
1984: Tew K D; Hartley-Asp B
Cytotoxic properties of estramustine unrelated to alkylating and steroid constituents.
Urology 1984;23(6 Suppl):28-33.
1983: Tew K D; Moy B C; Hartley-Asp B
Acquired drug resistance is accompanied by modification in the karyotype and nuclear matrix of a rat carcinoma cell line.
Experimental cell research 1983;149(2):443-50.
1983: Tew K D; Wang A L; Schein P S
Alkylating agent interactions with the nuclear matrix.
Biochemical pharmacology 1983;32(23):3509-16.
1983: Tew K D; Erickson L C; White G; Wang A L; Schein P S; Hartley-Asp B
Cytotoxicity of estramustine, a steroid-nitrogen mustard derivative, through non-DNA targets.
Molecular pharmacology 1983;24(2):324-8.
1983: Tew K D
The mechanism of action of estramustine.
Seminars in oncology 1983;10(3 Suppl 3):21-6.
1983: Wang A L; Schein P S; Tew K D
Importance of phospholipids to nitrosourea interactions with the nuclear envelope and associated nucleic acids.
Oncology 1983;40(5):367-71.
1982: Tew K D
Comparative cytotoxic properties of ifosfamide and cyclophosphamide in rat solid tumor and normal tissues.
Seminars in oncology 1982;9(4 Suppl 1):24-7.
1982: Ahlgren J D; Green D C; Tew K D; Schein P S
Repair of DNA alkylation induced in L1210 leukemia and murine bone marrow by three chloroethylnitrosoureas.
Cancer research 1982;42(7):2605-8.
1982: Tew K D; Wang A L
Selective cytotoxicity of haloethylnitrosoureas in a carcinoma cell line resistant to bifunctional nitrogen mustards.
Molecular pharmacology 1982;21(3):729-38.
1982: Green D; Tew K D; Hisamatsu T; Schein P S
Correlation of nitrosourea murine bone marrow toxicity with deoxyribonucleic acid alkylation and chromatin binding sites.
Biochemical pharmacology 1982;31(9):1671-9.
1982: Tew K D; Wang A L; Lindner D J; Schein P S
Enhancement of nitrosourea cytotoxicity in vitro using hydrocortisone.
Biochemical pharmacology 1982;31(6):1179-80.
1981: Tew K D; Smulson M E; Schein P S
Molecular pharmacology of nitrosoureas.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1981;76():130-40.
1981: Wang A L; Tew K D; Byrne P J; Schein P S
Biochemical and pharmacologic properties of nitrosoureas.
Cancer treatment reports 1981;65 Suppl 3():119-24.
1980: Tew K D; Schein P S; Lindner D J; Wang A L; Smulson M E
Influence of hydrocortisone on the binding of nitrosoureas to nuclear chromatin subfractions.
Cancer research 1980;40(10):3697-3703.
1980: Jump D B; Sudhakar S; Tew K D; Smulson M
Probes to study the effect of methyl nitrosourea on ADP-ribosylation and chromatin structure at the subunit level.
Chemico-biological interactions 1980;30(1):35-51.
1980: Tew K D; Taylor D M
Cyclophosphamide and cis-dichlorodiammine platinum (11). Nonempiric scheduling to spare dose-limiting tissues in the rat.
Cancer chemotherapy and pharmacology 1980;4(2):103-9.
1979: Sudhakar S; Tew K D; Schein P S; Woolley P V; Smulson M E
Nitrosourea interaction with chromatin and effect on poly(adenosine diphosphate ribose) polymerase activity.
Cancer research 1979;39(4):1411-7.
1979: Sudhakar S; Tew K D; Smulson M E
Effect of 1-methyl-1-nitrosourea on poly(adenosine diphosphate-ribose) polymerase activity at the nucleosomal level.
Cancer research 1979;39(4):1405-10.
1979: Pinsky S D; Tew K D; Smulson M E; Woolley P V
Modification of L1210 cell nuclear proteins by 1-methyl-1-nitrosourea and 1-methyl-3-nitro-1-nitrosoguanidine.
Cancer research 1979;39(3):923-8.
1978: Tew K D; Sudhakar S; Schein P S; Smulson M E
Binding of chlorozotocin and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea to chromatin and nucleosomal fractions of HeLa cells.
Cancer research 1978;38(10):3371-8.
1978: Tew K D; Taylor D M
Tissue distribution and nucleic acid binding of chlorambucil-3H in tumor-bearing rats.
Experientia 1978;34(9):1215-6.
1978: Tew K D; Taylor D M
The relationship of thymidine metabolism to the use of fractional incorporation as a measure of DNA synthesis and tissue proliferation.
European journal of cancer 1978;14(2):153-68.
1977: Tew K D; Taylor D M
Studies with cyclophosphamide labeled with phosphorus-32: nucleic acid alkylation and its effect on DNA synthesis in rat tumor and normal tissues.
Journal of the National Cancer Institute 1977;58(5):1413-9.
1977: Tew K D; Taylor D M
The effect of methotrexate on the uptake of de novo and salvage precursors into the DNA of rat tumours and normal tissues.
European journal of cancer 1977;13(3):279-89.
1976: Houghton P J; Tew K D; Taylor D M
Some studies on the distribution and effects of cyclophosphamide (NSC-26271) in normal and neoplastic tissue.
Cancer treatment reports 1976;60(4):459-64.
1976: Taylor D M; Tew K D; Jones J D
Effects of cis-dichlorodiammine platinum (II) on DNA synthesis in kidney and other tissues of normal and tumour-bearing rats.
European journal of cancer 1976;12(4):249-54.

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