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Jürgen Borlak

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Yuping Wang; Jie Zhang; Jürgen Borlak; Minjun Chen; Weigong Ge; Stephen Harris; Reagan Kelly; Zhi Lin; Zhichao Liu; Weida Tong
A unifying ontology to integrate histological and clinical observations for drug-induced liver injury.
Philip Stegmaier; Edgar Wingender; Alexander Kel; Jürgen Borlak
A discriminative approach for unsupervised clustering of DNA sequence motifs.
Jeong Kyu Kim; Min Gyu Kim; Jung Young Lee; Hyun Jin Bae; Jürgen Borlak; Young Gyoon Chang; Jung Woo Eun; Kwang Hwa Jung; Ji Heon Noh; Won Sang Park; Qingyu Shen; Suk Woo Nam
Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b.

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2013: Yuping Wang; Jie Zhang; Jürgen Borlak; Minjun Chen; Weigong Ge; Stephen Harris; Reagan Kelly; Zhi Lin; Zhichao Liu; Weida Tong
A unifying ontology to integrate histological and clinical observations for drug-induced liver injury.
The American journal of pathology 2013;182(4):1180-7.
2013: Philip Stegmaier; Edgar Wingender; Alexander Kel; Jürgen Borlak
A discriminative approach for unsupervised clustering of DNA sequence motifs.
PLoS computational biology 2013;9(3):e1002958.
2013: Jeong Kyu Kim; Min Gyu Kim; Jung Young Lee; Hyun Jin Bae; Jürgen Borlak; Young Gyoon Chang; Jung Woo Eun; Kwang Hwa Jung; Ji Heon Noh; Won Sang Park; Qingyu Shen; Suk Woo Nam
Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b.
Hepatology (Baltimore, Md.) 2013;57(3):1055-67.
2013: JK Kim; Min Gyu Kim; Seung-Jin Kim; Jung Young Lee; Hyun Jin Bae; Jürgen Borlak; Young Gyoon Chang; Jung Woo Eun; Kwang Hwa Jung; Ji Heon Noh; Won Sang Park; Qingyu Shen; Suk Woo Nam
Targeted inactivation of HDAC2 restores p16INK4a activity and exerts antitumor effects on human gastric cancer.
Molecular cancer research : MCR 2013;11(1):62-73.
2012: Minjun Chen; Jürgen Borlak; Min Zhang; Weida Tong
A decade of toxicogenomic research and its contribution to toxicological science.
Toxicological sciences : an official journal of the Society of Toxicology 2012;130(2):217-28.
2012: Carolin Zwadlo; Jürgen Borlak
Dihydrotestosterone--a culprit in left ventricular hypertrophy.
International journal of cardiology 2012;155(3):452-6.
2012: Thomas Rodt; Frank Wacker; Claudia Boehm; Jürgen Borlak; Silke Glage; Roman Halter; Ludwig Hoy; Katja Hueper; Matthias Luepke; Christian von Falck
Combined micro-PET/micro-CT imaging of lung tumours in SPC-raf and SPC-myc transgenic mice.
PloS one 2012;7(9):e44427.
2012: Stella Marie Reamon-Buettner; Jürgen Borlak
Dissecting epigenetic silencing complexity in the mouse lung cancer suppressor gene Cadm1.
PloS one 2012;7(6):e38531.
2011: Maria Stella Ritorto; Jürgen Borlak
Combined serum and tissue proteomic study applied to a c-Myc transgenic mouse model of hepatocellular carcinoma identified novel disease regulated proteins suitable for diagnosis and therapeutic intervention strategies.
Journal of proteome research 2011;10(7):3012-30.
2011: Florian Puls; Clemens Agne; Fritz Klein; Martin Koch; Kinan Rifai; Michael P Manns; Jürgen Borlak; Hans H Kreipe
Pathology of flupirtine-induced liver injury: a histological and clinical study of six cases.
Virchows Archiv : an international journal of pathology 2011;458(6):709-16.
2011: Thomas Rodt; Matthias Luepke; Claudia Boehm; Christian von Falck; Georg Stamm; Jürgen Borlak; Hermann Seifert; Michael Galanski
Phantom and cadaver measurements of dose and dose distribution in micro-CT of the chest in mice.
Acta radiologica (Stockholm, Sweden : 1987) 2011;52(1):75-80.
2011: Fridtjof Weltmeier; Jürgen Borlak
A high resolution genome-wide scan of HNF4α recognition sites infers a regulatory gene network in colon cancer.
PloS one 2011;6(7):e21667.
2011: Monika Niehof; Jürgen Borlak
HNF4alpha dysfunction as a molecular rational for cyclosporine induced hypertension.
PloS one 2011;6(1):e16319.
2010: Stella Marie Reamon-Buettner; Jürgen Borlak
NKX2-5: an update on this hypermutable homeodomain protein and its role in human congenital heart disease (CHD).
Human mutation 2010;31(11):1185-94.
2010: Astrid Rohrbeck; Gabriela Salinas; Kerstin Maaser; Jens Linge; Susan Salovaara; Raffaella Corvi; Jürgen Borlak
Toxicogenomics applied to in vitro carcinogenicity testing with Balb/c 3T3 cells revealed a gene signature predictive of chemical carcinogens.
Toxicological sciences : an official journal of the Society of Toxicology 2010;118(1):31-41.
2010: Ignazio Garaguso; Roman Halter; Jacek Krzeminski; Shantu Amin; Jürgen Borlak
Method for the rapid detection and molecular characterization of DNA alkylating agents by MALDI-TOF mass spectrometry.
Analytical chemistry 2010;82(20):8573-82.
2010: Thomas Thum; Sandor Batkai; Philipp G Malinski; Thomas Becker; Iris Mevius; Jürgen Klempnauer; Hartmut H Meyer; Jürgen C Frölich; Jürgen Borlak; Dimitrios Tsikas
Measurement and diagnostic use of hepatic cytochrome P450 metabolism of oleic acid in liver disease.
Liver international : official journal of the International Association for the Study of the Liver 2010;30(8):1181-8.
2010: Carolin Zwadlo; Jürgen Borlak
Impaired tissue clearance of verapamil in rat cardiac hypertrophy results in transcriptional repression of ion channels.
Xenobiotica; the fate of foreign compounds in biological systems 2010;40(4):291-9.
2010: Thomas Rodt; Christian von Falck; Sabine Dettmer; Roman Halter; Regina Maus; Kjetil Ask; Martin Kolb; Jack Gauldie; Florian Länger; Ludwig Hoy; Tobias Welte; Michael Galanski; Ulrich A Maus; Jürgen Borlak
Micro-computed tomography of pulmonary fibrosis in mice induced by adenoviral gene transfer of biologically active transforming growth factor-β1.
Respiratory research 2010;11():181.
2010: Frank Lehner; Ulf Kulik; Juergen Klempnauer; Jürgen Borlak
Inhibition of the liver enriched protein FOXA2 recovers HNF6 activity in human colon carcinoma and liver hepatoma cells.
PloS one 2010;5(10):e13344.
2010: David C Fritzinger; Robin Dean; Carol Meschter; Katina Wong; Roman Halter; Jürgen Borlak; William D St John; Carl-Wilhelm Vogel
Complement depletion with humanized cobra venom factor in a mouse model of age-related macular degeneration.
Advances in experimental medicine and biology 2010;703():151-62.
2009: Nora Anderson; Tatjana Meier; Jürgen Borlak
Toxicogenomics applied to cultures of human hepatocytes enabled an identification of novel petasites hybridus extracts for the treatment of migraine with improved hepatobiliary safety.
Toxicological sciences : an official journal of the Society of Toxicology 2009;112(2):507-20.
2009: Bengt Långström; Anders Grahnen; Per Hartvig Honoré; Jürgen Borlak; Mats Bergstrom; Bengt Nielsen; Jean-Luc Vanderheyden; Yasuyoshi Watanabe; Raymond Josephsson; Poul F Høilund-Carlsen; Markus Schwaiger; Steven M Larson; David M Goldenberg; Andreas Melzer; Henry Engler; Rodney Hicks; Anders Sundin; Marko Seppänen; Göran Hedenstierna; agneta nordberg; David Brooks
The risk of exaggerated risk aversion-a life and death struggle for molecular imaging.
European journal of nuclear medicine and molecular imaging 2009;36(10):1693-4.
2009: Stella Marie Reamon-Buettner; Yari Ciribilli; Ilaria Traverso; Beate Kuhls; Alberto Inga; Jürgen Borlak
A functional genetic study identifies HAND1 mutations in septation defects of the human heart.
Human molecular genetics 2009;18(19):3567-78.
2009: Marcin Nowicki; Joanna Kosacka; Katharina Spanel-Borowski; Jürgen Borlak
Deferoxamine-induced neurite outgrowth and synapse formation in postnatal rat dorsal root ganglion (DRG) cell cultures.
European journal of cell biology 2009;88(10):551-62.
2009: Joanna Kosacka; M Gericke; Marcin Nowicki; Johannes Kacza; Jürgen Borlak; Katharina Spanel-Borowski
Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures.
Neuroscience 2009;162(2):282-91.
2009: Bijon Chatterji; Jürgen Borlak
A 2-DE MALDI-TOF study to identify disease regulated serum proteins in lung cancer of c-myc transgenic mice.
Proteomics 2009;9(4):1044-56.
2009: Frank Lehner; Thomas Becker; Jürgen Klempnauer; Jürgen Borlak
Gender-incompatible liver transplantation is not a risk factor for patient survival.
Liver international : official journal of the International Association for the Study of the Liver 2009;29(2):196-202.
2009: Astrid Rohrbeck; Jürgen Borlak
Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1.
PloS one 2009;4(10):e7315.
2009: Giuseppe Gazzana; Jürgen Borlak
An update on the mouse liver proteome.
Proteome science 2009;7():35.
2009: Monika Niehof; Jürgen Borlak
Expression of HNF4alpha in the human and rat choroid plexus: implications for drug transport across the blood-cerebrospinal-fluid (CSF) barrier.
BMC molecular biology 2009;10():68.
2009: Astrid Rohrbeck; Volker Steffen Müller; Jürgen Borlak
Molecular characterization of lung dysplasia induced by c-Raf-1.
PloS one 2009;4(5):e5637.
2009: Jürgen Borlak; Monika Niehof
HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus.
PloS one 2009;4(3):e4662.
2008: Andreas Beineke; Stefanie Markus; Jürgen Borlak; Thomas Thum; Wolfgang Baumgärtner
Increase of pro-inflammatory cytokine expression in non-demyelinating early cerebral lesions in nervous canine distemper.
Viral immunology 2008;21(4):401-10.
2008: Stella Marie Reamon-Buettner; Jürgen Borlak
Epigenetic silencing of cell adhesion molecule 1 in different cancer progenitor cells of transgenic c-Myc and c-Raf mouse lung tumors.
Cancer research 2008;68(18):7587-96.
2008: Nora Anderson; Jürgen Borlak
Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis.
Pharmacological reviews 2008;60(3):311-57.
2008: Jürgen Borlak; Hans Stephan Jenke
Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation.
Molecular cancer research : MCR 2008;6(8):1326-36.
2008: Thomas Thum; Jürgen Borlak
LOX-1 receptor blockade abrogates oxLDL-induced oxidative DNA damage and prevents activation of the transcriptional repressor Oct-1 in human coronary arterial endothelium.
The Journal of biological chemistry 2008;283(28):19456-64.
2008: Moritz Kleine; Harald Schrem; Jürgen Borlak; Jürgen Klempnauer
Clinical versatility of porcine hepatocytes in the light of interspecies differences in cytochrome P450 regulation and expression.
Xenotransplantation 2008;15(4):208-17.
2008: Ignazio Garaguso; Jürgen Borlak
Matrix layer sample preparation: an improved MALDI-MS peptide analysis method for proteomic studies.
Proteomics 2008;8(13):2583-95.
2008: Stella Marie Reamon-Buettner; Vanessa Mutschler; Jürgen Borlak
The next innovation cycle in toxicogenomics: environmental epigenetics.
Mutation research 2008;659(1-2):158-65.
2008: V Vi Pham; Dirk O Stichtenoth; Jürgen Borlak
Graft rejection: pharmacogenetic analysis or drug anamnesis?
British journal of clinical pharmacology 2008;65(6):959-60.
2008: Stella Marie Reamon-Buettner; Yari Ciribilli; Alberto Inga; Jürgen Borlak
A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human hearts.
Human molecular genetics 2008;17(10):1397-405.
2008: Monika Niehof; Jürgen Borlak
EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.
Gastroenterology 2008;134(4):1191-202.
2008: Jutta Lamlé; Silke Marhenke; Jürgen Borlak; Reinhard von Wasielewski; C J Peter Eriksson; Robert Geffers; Michael P Manns; Masayuki Yamamoto; Arndt Vogel
Nuclear factor-eythroid 2-related factor 2 prevents alcohol-induced fulminant liver injury.
Gastroenterology 2008;134(4):1159-68.
2008: Monika Niehof; Jürgen Borlak
HNF4 alpha and the Ca-channel TRPC1 are novel disease candidate genes in diabetic nephropathy.
Diabetes 2008;57(4):1069-77.
2008: Giuseppe Gazzana; Jürgen Borlak
Mapping of the serum proteome of hepatocellular carcinoma induced by targeted overexpression of epidermal growth factor to liver cells of transgenic mice.
Journal of proteome research 2008;7(3):928-37.
2008: Thomas Thum; Jürgen Borlak
Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes.
Archives of toxicology 2008;82(2):89-101.
2008: Maria Stella Ritorto; Jürgen Borlak
A simple and reliable protocol for mouse serum proteome profiling studies by use of two-dimensional electrophoresis and MALDI TOF/TOF mass spectrometry.
Proteome science 2008;6():25.
2008: Susanne Reymann; Jürgen Borlak
Topoisomerase II inhibition involves characteristic chromosomal expression patterns.
BMC genomics 2008;9():324.
2008: Susanne Reymann; Jürgen Borlak
Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: identification of the c-myc regulatory gene network.
BMC systems biology 2008;2():46.
2008: Alexander E Kel; Monika Niehof; Volker Matys; Rüdiger Zemlin; Jürgen Borlak
Genome wide prediction of HNF4alpha functional binding sites by the use of local and global sequence context.
Genome biology 2008;9(2):R36.
2008: Sven Schuchardt; Jürgen Borlak
Quantitative mass spectrometry to investigate epidermal growth factor receptor phosphorylation dynamics.
Mass spectrometry reviews 2008;27(1):51-65.
2007: Bijon Chatterji; Jürgen Borlak
Serum proteomics of lung adenocarcinomas induced by targeted overexpression of c-raf in alveolar epithelium identifies candidate biomarkers.
Proteomics 2007;7(21):3980-91.
2007: Marcin Nowicki; Joanna Kosacka; Reinhard Brossmer; Katharina Spanel-Borowski; Jürgen Borlak
The myelin-associated glycoprotein inhibitor BENZ induces outgrowth and survival of rat dorsal root ganglion cell cultures.
Journal of neuroscience research 2007;85(14):3053-63.
2007: Marcin Nowicki; Olga Zabirnyk; Nicole Duerrschmidt; Jürgen Borlak; Katharina Spanel-Borowski
No upregulation of lectin-like oxidized low-density lipoprotein receptor-1 in serum-deprived EA.hy926 endothelial cells under oxLDL exposure, but increase in autophagy.
European journal of cell biology 2007;86(10):605-16.
2007: Emmanuelle Kuntz; Jürgen Borlak; Georges Riss; Claude-Pierre Aebischer; Heinrich Bachmann; Nicole Seifert; Petra Buchwald Hunziker; Dörte Sölle; Willi Hunziker; Regina Goralczyk; Karin Wertz
Transcriptomics does not show adverse effects of beta-carotene in A/J mice exposed to smoke for 2 weeks.
Archives of biochemistry and biophysics 2007;465(2):336-46.
2007: Giuseppe Gazzana; Jürgen Borlak
Improved method for proteome mapping of the liver by 2-DE MALDI-TOF MS.
Journal of proteome research 2007;6(8):3143-51.
2007: Thomas Thum; Paolo Galuppo; Christian Wolf; Jan Fiedler; Susanne Kneitz; Linda W van Laake; Pieter A Doevendans; Christine L Mummery; Jürgen Borlak; Axel Haverich; Carina Gross; Stefan Engelhardt; Georg Ertl; Johann Bauersachs
MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure.
Circulation 2007;116(3):258-67.
2007: Stella Marie Reamon-Buettner; Jürgen Borlak
A new paradigm in toxicology and teratology: altering gene activity in the absence of DNA sequence variation.
Reproductive toxicology (Elmsford, N.Y.) 2007;24(1):20-30.
2007: Tanja Hansen; Albrecht Seidel; Jürgen Borlak
The environmental carcinogen 3-nitrobenzanthrone and its main metabolite 3-aminobenzanthrone enhance formation of reactive oxygen intermediates in human A549 lung epithelial cells.
Toxicology and applied pharmacology 2007;221(2):222-34.
2007: Frank Lehner; U Kulik; Jürgen Klempnauer; Jürgen Borlak
The hepatocyte nuclear factor 6 (HNF6) and FOXA2 are key regulators in colorectal liver metastases.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(7):1445-62.
2007: Thomas Thum; Sarah Hoeber; Sabrina Froese; Ivonne Klink; Dirk O Stichtenoth; Paolo Galuppo; Marten Jakob; Dimitrios Tsikas; Stefan D Anker; Philip A Poole-Wilson; Jürgen Borlak; Georg Ertl; Johann Bauersachs
Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1.
Circulation research 2007;100(3):434-43.
2007: Stella Marie Reamon-Buettner; Si-Hyen Cho; Jürgen Borlak
Mutations in the 3'-untranslated region of GATA4 as molecular hotspots for congenital heart disease (CHD).
BMC medical genetics 2007;8():38.
2006: Harald Schrem; Moritz Kleine; Jürgen Borlak; Jürgen Klempnauer
Physiological incompatibilities of porcine hepatocytes for clinical liver support.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2006;12(12):1832-40.
2006: Thomas Thum; Veit J Erpenbeck; Julia Moeller; Jens Hohlfeld; Norbert Krug; Jürgen Borlak
Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers.
Environmental health perspectives 2006;114(11):1655-61.
2006: Nora Anderson; Jürgen Borlak
Drug-induced phospholipidosis.
FEBS letters 2006;580(23):5533-40.
2006: Stephan Gebel; Bernhard Gerstmayer; Peter Kuhl; Jürgen Borlak; Kris Meurrens; Thomas Müller
The kinetics of transcriptomic changes induced by cigarette smoke in rat lungs reveals a specific program of defense, inflammation, and circadian clock gene expression.
Toxicological sciences : an official journal of the Society of Toxicology 2006;93(2):422-31.
2006: Stella Marie Reamon-Buettner; Jürgen Borlak
Somatic mutations in cardiac malformations.
Journal of medical genetics 2006;43(8):e45.
2006: Nicole Duerrschmidt; Olga Zabirnyk; Marcin Nowicki; Albert M Ricken; Fayez A Hmeidan; Verona Blumenauer; Jürgen Borlak; Katharina Spanel-Borowski
Lectin-like oxidized low-density lipoprotein receptor-1-mediated autophagy in human granulosa cells as an alternative of programmed cell death.
Endocrinology 2006;147(8):3851-60.
2006: Tanja Hansen; Maren Blickwede; Jürgen Borlak
Primary rat alveolar epithelial cells for use in biotransformation and toxicity studies.
Toxicology in vitro : an international journal published in association with BIBRA 2006;20(5):757-66.
2006: Nils-Holger Zschemisch; Christian Liedtke; Uta Dierssen; Yulia A Nevzorova; Torsten Wüstefeld; Jürgen Borlak; Michael P Manns; Christian Trautwein
Expression of a cyclin E1 isoform in mice is correlated with the quiescent cell cycle status of hepatocytes in vivo.
Hepatology (Baltimore, Md.) 2006;44(1):164-73.
2006: Carolin Zwadlo; Jürgen Borlak
Nifedipine represses ion channels, transporters and Ca(2+)-binding proteins in hearts of spontaneously hypertensive rats.
Toxicology and applied pharmacology 2006;213(3):224-34.
2006: Jürgen Borlak; Antje Gasparic; Mathias Locher; Hubert Schupke; Robert Hermann
N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II.
Metabolism: clinical and experimental 2006;55(6):711-21.
2006: Joanna Kosacka; Marcin Nowicki; Johannes Kacza; Jürgen Borlak; Jürgen Engele; Katharina Spanel-Borowski
Adipocyte-derived angiopoietin-1 supports neurite outgrowth and synaptogenesis of sensory neurons.
Journal of neuroscience research 2006;83(7):1160-9.
2006: Stella Marie Reamon-Buettner; Katharina Spanel-Borowski; Jürgen Borlak
Bridging the gap between anatomy and molecular genetics for an improved understanding of congenital heart disease.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2006;188(3):213-20.
2006: Heike Rütters; Petra Zürbig; Roman Halter; Jürgen Borlak
Towards a lung adenocarcinoma proteome map: studies with SP-C/c-raf transgenic mice.
Proteomics 2006;6(10):3127-37.
2006: Robert Hermann; Jürgen Borlak; U Munzel; Georg Niebch; Uwe Fuhr; Joachim Maus; Katharina Erb
The role of Gilbert's syndrome and frequent NAT2 slow acetylation polymorphisms in the pharmacokinetics of retigabine.
The pharmacogenomics journal 2006;6(3):211-9.
2006: Ingo Schulte; Huseyin Bektas; Jürgen Klempnauer; Jürgen Borlak
Vitamin E in heart transplantation: effects on cardiac gene expression.
Transplantation 2006;81(5):736-45.
2006: Susanne Reymann; Jürgen Borlak
Transcriptome profiling of human hepatocytes treated with Aroclor 1254 reveals transcription factor regulatory networks and clusters of regulated genes.
BMC genomics 2006;7():217.
2006: Jürgen Borlak; Stella Marie Reamon-Buettner
N-acetyltransferase 2 (NAT2) gene polymorphisms in colon and lung cancer patients.
BMC medical genetics 2006;7():58.
2006: Jürgen Borlak; Stella Marie Reamon-Buettner
N-acetyltransferase 2 (NAT2) gene polymorphisms in Parkinson's disease.
BMC medical genetics 2006;7():30.
2006: Stella Marie Reamon-Buettner; Jürgen Borlak
HEY2 mutations in malformed hearts.
Human mutation 2006;27(1):118.
2005: Christian Liedtke; Nils-Holger Zschemisch; Anne Cohrs; Tania Roskams; Jürgen Borlak; Michael P Manns; Christian Trautwein
Silencing of caspase-8 in murine hepatocellular carcinomas is mediated via methylation of an essential promoter element.
Gastroenterology 2005;129(5):1602-15.
2005: Maren Blickwede; Jürgen Borlak
Isolation and characterization of metabolically competent pulmonary epithelial cells from pig lung tissue.
Xenobiotica; the fate of foreign compounds in biological systems 2005;35(10-11):927-41.
2005: Carolin Zwadlo; Jürgen Borlak
Disease-associated changes in the expression of ion channels, ion receptors, ion exchangers and Ca(2+)-handling proteins in heart hypertrophy.
Toxicology and applied pharmacology 2005;207(3):244-56.
2005: V Zelinski; Jürgen Borlak
Identification and quantification of metabolites of arachidonic acid from cultures of endothelial cells by HPLC-MS2.
Xenobiotica; the fate of foreign compounds in biological systems 2005;35(8):811-23.
2005: Jürgen Borlak; Maren Blickwede; Tanja Hansen; Wolfgang Koch; Markus Walles; Karsten Levsen
Metabolism of verapamil in cultures of rat alveolar epithelial cells and pharmacokinetics after administration by intravenous and inhalation routes.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(8):1108-14.
2005: Alberto Inga; Stella Marie Reamon-Buettner; Jürgen Borlak; Michael A Resnick
Functional dissection of sequence-specific NKX2-5 DNA binding domain mutations associated with human heart septation defects using a yeast-based system.
Human molecular genetics 2005;14(14):1965-75.
2005: Sm Reamon-Buettner; Jürgen Borlak
Genetic analysis of cardiac-specific transcription factors reveals novel insights into molecular causes of congenital heart disease.
Future cardiology 2005;1(3):355-61.
2005: Stella Marie Reamon-Buettner; Jürgen Borlak
GATA4 zinc finger mutations as a molecular rationale for septation defects of the human heart.
Journal of medical genetics 2005;42(5):e32.
2005: Thomas Jacobs; Jörg Andrä; Iris Gaworski; Sebastian E B Graefe; Katja Mellenthin; Manfred Krömer; Roman Halter; Jürgen Borlak; Joachim Clos
Complement C3 is required for the progression of cutaneous lesions and neutrophil attraction in Leishmania major infection.
Medical microbiology and immunology 2005;194(3):143-9.
2005: Jürgen Borlak; Tatiana Meier; Roman Halter; Reinhard Spanel; Katharina Spanel-Borowski
Epidermal growth factor-induced hepatocellular carcinoma: gene expression profiles in precursor lesions, early stage and solitary tumours.
Oncogene 2005;24(11):1809-19.
2005: Monika Niehof; Jürgen Borlak
RSK4 and PAK5 are novel candidate genes in diabetic rat kidney and brain.
Molecular pharmacology 2005;67(3):604-11.
2005: Ralf Gerhard; Helma Tatge; Harald Genth; Thomas Thum; Jürgen Borlak; Gerhard Fritz; Ingo Just
Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB.
The Journal of biological chemistry 2005;280(2):1499-505.
2004: Alexander Kel; Susanne Reymann; Volker Matys; Paul Nettesheim; Edgar Wingender; Jürgen Borlak
A novel computational approach for the prediction of networked transcription factors of aryl hydrocarbon-receptor-regulated genes.
Molecular pharmacology 2004;66(6):1557-72.
2004: Jürgen Borlak; T Klutcka
Expression of basolateral and canalicular transporters in rat liver and cultures of primary hepatocytes.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(11-12):935-47.
2004: Fortunato Scalera; Jürgen Borlak; Bibiana Beckmann; Jens Martens-Lobenhoffer; Thomas Thum; Michael Täger; Stefanie M Bode-Böger
Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(10):1816-22.
2004: Stella Marie Reamon-Buettner; Jürgen Borlak
Somatic NKX2-5 mutations as a novel mechanism of disease in complex congenital heart disease.
Journal of medical genetics 2004;41(9):684-90.
2004: Jürgen Borlak; Carolin Zwadlo
The myosin ATPase inhibitor 2,3-butanedione monoxime dictates transcriptional activation of ion channels and Ca(2+)-handling proteins.
Molecular pharmacology 2004;66(3):708-17.
2004: Stella Marie Reamon-Buettner; Jürgen Borlak
TBX5 mutations in non-Holt-Oram syndrome (HOS) malformed hearts.
Human mutation 2004;24(1):104.
2004: Harald Schrem; Jürgen Klempnauer; Jürgen Borlak
Liver-enriched transcription factors in liver function and development. Part II: the C/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation.
Pharmacological reviews 2004;56(2):291-330.
2004: Stella Marie Reamon-Buettner; Hartmut Hecker; Katharina Spanel-Borowski; Steffen Craatz; Eberhard Kuenzel; Jürgen Borlak
Novel NKX2-5 mutations in diseased heart tissues of patients with cardiac malformations.
The American journal of pathology 2004;164(6):2117-25.
2004: Jürgen Borlak; Ingo Schulte; Thomas Thum
Androgen metabolism in thymus of fetal and adult rats.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(6):675-9.
2004: Wayne M Mullett; Markus Walles; Karsten Levsen; Jürgen Borlak; Janusz Pawliszyn
Multidimensional on-line sample preparation of verapamil and its metabolites by a molecularly imprinted polymer coupled to liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;801(2):297-306.
2004: Alexander Jetter; Martina Kinzig; Michael Illauer; Robert Hermann; Katharina Erb; Jürgen Borlak; Helga Wolf; Gillian Smith; Ingolf Cascorbi; Fritz Sörgel; Uwe Fuhr
Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure.
European journal of clinical pharmacology 2004;60(1):17-21.
2004: Thomas Thum; Jürgen Borlak
Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein-induced vascular injury: therapy through LOX-1 receptor antagonism?
Circulation research 2004;94(1):e1-13.
2003: Markus Walles; Thomas Thum; Karsten Levsen; Jürgen Borlak
Metabolism of verapamil: 24 new phase I and phase II metabolites identified in cell cultures of rat hepatocytes by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;798(2):265-74.
2003: Thomas Thum; Dimitrios Tsikas; Juergen Dr.Froelich; Jürgen Borlak
Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line.
FEBS letters 2003;555(3):567-71.
2003: Jürgen Borlak; Robert Hermann; Katharina Erb; Thomas Thum
A rapid and simple CYP2D6 genotyping assay--case study with the analgetic tramadol.
Metabolism: clinical and experimental 2003;52(11):1439-43.
2003: Jürgen Borlak; Carolin Zwadlo
Expression of drug-metabolizing enzymes, nuclear transcription factors and ABC transporters in Caco-2 cells.
Xenobiotica; the fate of foreign compounds in biological systems 2003;33(9):927-43.
2003: Jürgen Borlak; Thomas Thum
Hallmarks of ion channel gene expression in end-stage heart failure.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(12):1592-608.
2003: Jürgen Borlak; Markus Walles; Karsten Levsen; Thomas Thum
Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(7):888-91.
2003: Jürgen Borlak; Markus Walles; Manfred Elend; Thomas Thum; Alfred Preiss; Karsten Levsen
Verapamil: identification of novel metabolites in cultures of primary human hepatocytes and human urine by LC-MS(n) and LC-NMR.
Xenobiotica; the fate of foreign compounds in biological systems 2003;33(6):655-76.
2003: Ines Lehner; Monika Niehof; Jürgen Borlak
An optimized method for the isolation and identification of membrane proteins.
Electrophoresis 2003;24(11):1795-808.
2003: Jürgen Borlak; Ariane Hock; Tanja Hansen; Elmar Richter
DNA adducts in cultures of polychlorinated biphenyl-treated human hepatocytes.
Toxicology and applied pharmacology 2003;188(2):81-91.
2003: Robert Hermann; Norbert Knebel; Georg Niebch; Lyette Richards; Jürgen Borlak; Mathias Locher
Pharmacokinetic interaction between retigabine and lamotrigine in healthy subjects.
European journal of clinical pharmacology 2003;58(12):795-802.
2002: Jürgen Borlak; Thomas Thum
PCBs alter gene expression of nuclear transcription factors and other heart-specific genes in cultures of primary cardiomyocytes: possible implications for cardiotoxicity.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(12):1173-83.
2002: Markus Walles; Jürgen Borlak; Karsten Levsen
Application of restricted access material (RAM) with precolumn-switching and matrix solid-phase dispersion (MSPD) to the study of the metabolism and pharmacokinetics of Verapamil.
Analytical and bioanalytical chemistry 2002;374(7-8):1179-86.
2002: Thomas Thum; Jürgen Borlak
Testosterone, cytochrome P450, and cardiac hypertrophy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(12):1537-49.
2002: Markus Walles; Thomas Thum; Karsten Levsen; Jürgen Borlak
Verapamil: new insight into the molecular mechanism of drug oxidation in the human heart.
Journal of chromatography. A 2002;970(1-2):117-30.
2002: Markus Walles; Wayne M Mullett; Karsten Levsen; Jürgen Borlak; G Wünsch; Janusz Pawliszyn
Verapamil drug metabolism studies by automated in-tube solid phase microextraction.
Journal of pharmaceutical and biomedical analysis 2002;30(2):307-19.
2002: Jürgen Borlak; Thomas Thum
Identification of major CYP2C9 and CYP2C19 polymorphisms by fluorescence resonance energy transfer analysis.
Clinical chemistry 2002;48(9):1592-4.
2002: Jürgen Borlak; Marc Dangers; Thomas Thum
Aroclor 1254 modulates gene expression of nuclear transcription factors: implications for albumin gene transcription and protein synthesis in rat hepatocyte cultures.
Toxicology and applied pharmacology 2002;181(2):79-88.
2002: Wayne M Mullett; Karsten Levsen; Jürgen Borlak; Jingcun Wu; Janusz Pawliszyn
Automated in-tube solid-phase microextraction coupled with HPLC for the determination of N-nitrosamines in cell cultures.
Analytical chemistry 2002;74(7):1695-701.
2002: Harald Schrem; Jürgen Klempnauer; Jürgen Borlak
Liver-enriched transcription factors in liver function and development. Part I: the hepatocyte nuclear factor network and liver-specific gene expression.
Pharmacological reviews 2002;54(1):129-58.
2001: Markus Walles; Thomas Thum; Karsten Levsen; Jürgen Borlak
Verapamil metabolism in distinct regions of the heart and in cultures of cardiomyocytes of adult rats.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(5):761-8.
2001: Wolfgang Koch; H Windt; Markus Walles; Jürgen Borlak; P Clausing
Inhalation studies with the Göttingen minipig.
Inhalation toxicology 2001;13(3):249-59.
2001: T Thum; Jürgen Borlak
Reprogramming of gene expression in cultured cardiomyocytes and in explanted hearts by the myosin ATPase inhibitor butanedione monoxime.
Transplantation 2001;71(4):543-52.
2001: Jürgen Borlak; Thomas Thum
Induction of nuclear transcription factors, cytochrome P450 monooxygenases, and glutathione S-transferase alpha gene expression in Aroclor 1254-treated rat hepatocyte cultures.
Biochemical pharmacology 2001;61(2):145-53.
2001: Thomas Thum; Jürgen Borlak
Butanedione monoxime increases the viability and yield of adult cardiomyocytes in primary cultures.
Cardiovascular toxicology 2001;1(1):61-72.
2000: Klaus Pethig; Bernd Heublein; A Hoffmann; Jürgen Borlak; Thorsten Wahlers; Axel Haverich
ACE-gene polymorphism is associated with the development of allograft vascular disease in heart transplant recipients.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2000;19(12):1175-82.
2000: Thomas Thum; Jürgen Borlak
Isolation and cultivation of Ca2+ tolerant cardiomyocytes from the adult rat: improvements and applications.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(11):1063-77.
2000: Jürgen Borlak; Thomas Thum; O Landt; K Erb; Robert Hermann
Molecular diagnosis of a familial nonhemolytic hyperbilirubinemia (Gilbert's syndrome) in healthy subjects.
Hepatology (Baltimore, Md.) 2000;32(4 Pt 1):792-5.
2000: Thomas Thum; Jürgen Borlak
Cytochrome P450 mono-oxygenase gene expression and protein activity in cultures of adult cardiomyocytes of the rat.
British journal of pharmacology 2000;130(8):1745-52.
2000: Rainer H Böger; Karsten Sydow; Jürgen Borlak; Thomas Thum; Henrike Lenzen; B Schubert; Dimitrios Tsikas; Stefanie M Bode-Böger
LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases.
Circulation research 2000;87(2):99-105.
2000: Thomas Thum; A Haverich; Jürgen Borlak
Cellular dedifferentiation of endothelium is linked to activation and silencing of certain nuclear transcription factors: implications for endothelial dysfunction and vascular biology.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(5):740-51.
2000: T Thum; Jürgen Borlak
Gene expression in distinct regions of the heart.
Lancet 2000;355(9208):979-83.
2000: T Hansen; Jürgen Borlak; Augustinus Bader
Cytochrome P450 enzyme activity and protein expression in primary porcine enterocyte and hepatocyte cultures.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(1):27-46.