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Manuel Than

Research Profile

Procedures

X Ray Crystallography

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Genes & Molecular Sequences

Amino Acid Sequences

Chemicals & Drugs

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Protein Binding

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Publications

TOP 3
Cora Keil; Klaus Maskos; Manuel E Than; J Todd Hoopes; Robert Huber; Fulong Tan; Peter A Deddish; Ervin G. Erdoes; Randal A Skidgel; Wolfram Bode
Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain.
Kerstin B Rohr; Trevor Selwood; Ulf Marquardt; Robert Huber; Norman M Schechter; Wolfram Bode; Manuel E Than
X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha-->beta-tryptase transition.
Magdalena Kacprzak; Manuel E Than; Luiz Juliano; Maria A Juliano; Wolfram Bode; Iris Lindberg
Mutations of the PC2 substrate binding pocket alter enzyme specificity.

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All Publications

2007: Cora Keil; Klaus Maskos; Manuel E Than; J Todd Hoopes; Robert Huber; Fulong Tan; Peter A Deddish; Ervin G. Erdoes; Randal A Skidgel; Wolfram Bode
Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain.
Journal of molecular biology 2007;366(2):504-16.
2006: Kerstin B Rohr; Trevor Selwood; Ulf Marquardt; Robert Huber; Norman M Schechter; Wolfram Bode; Manuel E Than
X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha-->beta-tryptase transition.
Journal of molecular biology 2006;357(1):195-209.
2005: Magdalena Kacprzak; Manuel E Than; Luiz Juliano; Maria A Juliano; Wolfram Bode; Iris Lindberg
Mutations of the PC2 substrate binding pocket alter enzyme specificity.
The Journal of biological chemistry 2005;280(36):31850-8.
2005: Manuel E Than; Gleb P Bourenkov; Stefan Henrich; Karlheinz Mann; Wolfram Bode
The NC1 dimer of human placental basement membrane collagen IV: does a covalent crosslink exist?
Biological chemistry 2005;386(8):759-66.
2005: Manuel E Than; Stefan Henrich; Gleb P Bourenkov; Hans D Bartunik; Robert Huber; Wolfram Bode
The endoproteinase furin contains two essential Ca2+ ions stabilizing its N-terminus and the unique S1 specificity pocket.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 5):505-12.
2005: Stefan Henrich; Iris Lindberg; Wolfram Bode; Manuel E Than
Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity.
Journal of molecular biology 2005;345(2):211-27.
2004: Cora Keil; Robert Huber; Wolfram Bode; Manuel E Than
Cloning, expression, crystallization and initial crystallographic analysis of the C-terminal domain of the amyloid precursor protein APP.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 9):1614-7.
2004: Magdalena Kacprzak; Juan Peinado; Manuel E Than; Jon Appel; Stefan Henrich; Gregory M Lipkind; Richard A Houghten; Wolfram Bode; Iris Lindberg
Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine.
The Journal of biological chemistry 2004;279(35):36788-94.
2003: Stefan Henrich; Angus Cameron; Gleb P Bourenkov; Reiner Kiefersauer; Robert Huber; Iris Lindberg; Wolfram Bode; Manuel E Than
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity.
Nature structural biology 2003;10(7):520-6.
2002: Manuel E Than; Stefan Henrich; Robert Huber; Albert Ries; Karlheinz Mann; Klaus Kühn; Rupert Timpl; Gleb P Bourenkov; Hans D Bartunik; Wolfram Bode
The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6607-12.
2000: Tewfik Soulimane; Manuel E Than; Manfred Dewor; Robert Huber; Gerhard Buse
Primary structure of a novel subunit in ba3-cytochrome oxidase from Thermus thermophilus.
Protein science : a publication of the Protein Society 2000;9(11):2068-73.
2000: Tewfik Soulimane; Gerhard Buse; Gleb P Bourenkov; Hans D Bartunik; Robert Huber; Manuel E Than
Structure and mechanism of the aberrant ba(3)-cytochrome c oxidase from thermus thermophilus.
The EMBO journal 2000;19(8):1766-76.
1999: J Schnackenberg; Manuel E Than; Karlheinz Mann; Georg Wiegand; Robert Huber; Wolfgang Reuter
Amino acid sequence, crystallization and structure determination of reduced and oxidized cytochrome c6 from the green alga Scenedesmus obliquus.
Journal of molecular biology 1999;290(5):1019-30.
1999: Wolfgang Reuter; Georg Wiegand; Robert Huber; Manuel E Than
Structural analysis at 2.2 A of orthorhombic crystals presents the asymmetry of the allophycocyanin-linker complex, AP.LC7.8, from phycobilisomes of Mastigocladus laminosus.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1363-8.
1999: Joao Dias; Manuel E Than; A Humm; Robert Huber; Gleb P Bourenkov; Hans D Bartunik; Sergey Bursakov; JJ Calvete; Jorge Caldeira; C Carneiro; José J G Moura; Isabel Moura; Maria João Romão
Crystal structure of the first dissimilatory nitrate reductase at 1.9 A solved by MAD methods.
Structure (London, England : 1993) 1999;7(1):65-79.
1997: Manuel E Than; P Hof; Robert Huber; Gleb P Bourenkov; Hans D Bartunik; Gerhard Buse; Tewfik Soulimane
Thermus thermophilus cytochrome-c552: A new highly thermostable cytochrome-c structure obtained by MAD phasing.
Journal of molecular biology 1997;271(4):629-44.
1997: Tewfik Soulimane; Matthias von Walter; P Hof; Manuel E Than; Robert Huber; Gerhard Buse
Cytochrome-c552 from Thermus thermophilus: a functional and crystallographic investigation.
Biochemical and biophysical research communications 1997;237(3):572-6.