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David Theakston

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Daniel Petras; Libia Sanz; Alvaro Segura; María Herrera; Mauren Villalta; Daniela Solano; Mariángela Vargas; Guillermo León; David A Warrell; R David G Theakston; Robert A Harrison; Nandul Durfa; Abdulsalami Nasidi; José María Gutiérrez; Juan J Calvete
Snake venomics of African spitting cobras: toxin composition and assessment of congeneric cross-reactivity of the pan-African EchiTAb-Plus-ICP antivenom by antivenomics and neutralization approaches.
Abul Faiz; Aniruddha Ghose; Farid Ahsan; Ridwanur Rahman; Robed Amin; Mahtab Uddin Hassan; A Wahed Chowdhury; Ulrich Kuch; Thalita Rocha; John B Harris; R David G Theakston; David A Warrell
The greater black krait (Bungarus niger), a newly recognized cause of neuro-myotoxic snake bite envenoming in Bangladesh.
Juan J Calvete; Pedro Cid; Libia Sanz; Alvaro Segura; Mauren Villalta; María Herrera; Guillermo León; Robert Harrison; Nandul Durfa; Abdulsalami Nasidi; R David G Theakston; David A Warrell; José María Gutiérrez
Antivenomic assessment of the immunological reactivity of EchiTAb-Plus-ICP, an antivenom for the treatment of snakebite envenoming in sub-Saharan Africa.

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All Publications

2011: Daniel Petras; Libia Sanz; Alvaro Segura; María Herrera; Mauren Villalta; Daniela Solano; Mariángela Vargas; Guillermo León; David A Warrell; R David G Theakston; Robert A Harrison; Nandul Durfa; Abdulsalami Nasidi; José María Gutiérrez; Juan J Calvete
Snake venomics of African spitting cobras: toxin composition and assessment of congeneric cross-reactivity of the pan-African EchiTAb-Plus-ICP antivenom by antivenomics and neutralization approaches.
Journal of proteome research 2011;10(3):1266-80.
2010: Abul Faiz; Aniruddha Ghose; Farid Ahsan; Ridwanur Rahman; Robed Amin; Mahtab Uddin Hassan; A Wahed Chowdhury; Ulrich Kuch; Thalita Rocha; John B Harris; R David G Theakston; David A Warrell
The greater black krait (Bungarus niger), a newly recognized cause of neuro-myotoxic snake bite envenoming in Bangladesh.
Brain : a journal of neurology 2010;133(11):3181-93.
2010: Juan J Calvete; Pedro Cid; Libia Sanz; Alvaro Segura; Mauren Villalta; María Herrera; Guillermo León; Robert Harrison; Nandul Durfa; Abdulsalami Nasidi; R David G Theakston; David A Warrell; José María Gutiérrez
Antivenomic assessment of the immunological reactivity of EchiTAb-Plus-ICP, an antivenom for the treatment of snakebite envenoming in sub-Saharan Africa.
The American journal of tropical medicine and hygiene 2010;82(6):1194-201.
2010: John B Harris; Md Abul Faiz; M Ridwanur Rahman; Md M A Jalil; Md Farid Ahsan; R David G Theakston; David A Warrell; Ulrich Kuch
Snake bite in Chittagong Division, Bangladesh: a study of bitten patients who developed no signs of systemic envenoming.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2010;104(5):320-7.
2010: Alvaro Segura; Mauren Villalta; María Herrera; Guillermo León; Robert Harrison; Nandul Durfa; Abdulsalami Nasidi; Juan J Calvete; R David G Theakston; David A Warrell; José María Gutiérrez
Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa.
Toxicon : official journal of the International Society on Toxinology 2010;55(2-3):369-74.
2010: Isa S Abubakar; Saidu B Abubakar; Abdulrazaq G Habib; Abdulsalami Nasidi; Nandul Durfa; Peter O Yusuf; Solomon Larnyang; John Garnvwa; Elijah Sokomba; Lateef Salako; R David G Theakston; Ed Juszczak; Nicola Alder; David A Warrell
Randomised controlled double-blind non-inferiority trial of two antivenoms for saw-scaled or carpet viper (Echis ocellatus) envenoming in Nigeria.
PLoS neglected tropical diseases 2010;4(7):e767.
2009: Elena J Caron; Stephen R Manock; Jeffrey Maudlin; Jerome Koleski; R David G Theakston; David A Warrell; Roger D Smalligan
Apparent marked reduction in early antivenom reactions compared to historical controls: was it prophylaxis or method of administration?
Toxicon : official journal of the International Society on Toxinology 2009;54(6):779-83.
2009: CA Ariaratnam; M H Rezvi Sheriff; Carukshi Arambepola; R David G Theakston; David A Warrell
Syndromic approach to treatment of snake bite in Sri Lanka based on results of a prospective national hospital-based survey of patients envenomed by identified snakes.
The American journal of tropical medicine and hygiene 2009;81(4):725-31.
2008: CA Ariaratnam; V Thuraisingam; S A M Kularatne; M H Rezvi Sheriff; R David G Theakston; A de Silva; David A Warrell
Frequent and potentially fatal envenoming by hump-nosed pit vipers (Hypnale hypnale and H. nepa) in Sri Lanka: lack of effective antivenom.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2008;102(11):1120-6.
2008: Christeine A Ariaratnam; M H Rezvi Sheriff; R David G Theakston; David A Warrell
Distinctive epidemiologic and clinical features of common krait (Bungarus caeruleus) bites in Sri Lanka.
The American journal of tropical medicine and hygiene 2008;79(3):458-62.
2008: Marcelo Larami Santoro; Ida Sigueko Sano-Martins; Hui W Fan; João Luiz Costa Cardoso; R David G Theakston; David A Warrell
Haematological evaluation of patients bitten by the jararaca, Bothrops jararaca, in Brazil.
Toxicon : official journal of the International Society on Toxinology 2008;51(8):1440-8.
2007: JM Howes; R David G Theakston; Gavin D Laing
Neutralization of the haemorrhagic activities of viperine snake venoms and venom metalloproteinases using synthetic peptide inhibitors and chelators.
Toxicon : official journal of the International Society on Toxinology 2007;49(5):734-9.
2006: Rafael Otero; Guillermo León; José María Gutiérrez; Gustavo Rojas; María Fabiola Toro; Jacqueline Barona; Verónica Rodríguez; Abel Díaz; Vitelbina Núñez; Juan Carlos Quintana; Shirley Ayala; Diana Mosquera; Lesdy L Conrado; Diego Fernández; Yobana Arroyo; Carlos A Paniagua; Mercedes López; Carlos E Ospina; Claudia Alzate; Jorge Fernández; Jazmín J Meza; Juan F Silva; Patricia Ramírez; Patricia E Fabra; Eugenio Ramírez; Elkin Córdoba; Ana B Arrieta; David A Warrell; R David G Theakston
Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without beta-propiolactone, in the treatment of Bothrops asper bites in Colombia.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2006;100(12):1173-82.
2006: Marcelo R V Diniz; R David G Theakston; Julian M Crampton; Marta do Nascimento Cordeiro; Adriano M C Pimenta; maria elena de lima; Carlos R Diniz
Functional expression and purification of recombinant Tx1, a sodium channel blocker neurotoxin from the venom of the Brazilian "armed" spider, Phoneutria nigriventer.
Protein expression and purification 2006;50(1):18-24.
2006: Simon C Wagstaff; Gavin D Laing; R David G Theakston; Christina Papaspyridis; Robert A Harrison
Bioinformatics and multiepitope DNA immunization to design rational snake antivenom.
PLoS medicine 2006;3(6):e184.
2006: José María Gutiérrez; R David G Theakston; David A Warrell
Confronting the neglected problem of snake bite envenoming: the need for a global partnership.
PLoS medicine 2006;3(6):e150.
2006: Yotis A Senis; Paul Y Kim; Gemma L J Fuller; Angel García; Sripadi Prabhakar; Mark C Wilkinson; Helen Brittan; Nicole Zitzmann; Robin Wait; David A Warrell; Steve P Watson; Aura S Kamiguti; R David G Theakston; Michael E Nesheim; Gavin D Laing
Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara.
Biochimica et biophysica acta 2006;1764(5):863-71.
2006: Robert A Harrison; SS Hasson; M Harmsen; Gavin D Laing; K Conrath; R David G Theakston
Neutralisation of venom-induced haemorrhage by IgG from camels and llamas immunised with viper venom and also by endogenous, non-IgG components in camelid sera.
Toxicon : official journal of the International Society on Toxinology 2006;47(3):364-8.
2006: Katsue Suzuki-Inoue; Gemma L J Fuller; Angel García; Johannes A Eble; Stefan Pöhlmann; Osamu Inoue; T Kent Gartner; Sascha C Hughan; Andrew C Pearce; Gavin D Laing; R David G Theakston; Edina Schweighoffer; Nicole Zitzmann; Takashi Morita; Victor L J Tybulewicz; Yukio Ozaki; Steve P Watson
A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.
Blood 2006;107(2):542-9.
2005: Gavin D Laing; Steven J Compton; Rithwik Ramachandran; Gemma L J Fuller; Mark C Wilkinson; Simon C Wagstaff; Steve P Watson; Aura S Kamiguti; R David G Theakston; Yotis A Senis
Characterization of a novel protein from Proatheris superciliaris venom: proatherocytin, a 34-kDa platelet receptor PAR1 agonist.
Toxicon : official journal of the International Society on Toxinology 2005;46(5):490-9.
2005: Paul Gallagher; Yongde Bao; Solange M T Serrano; Gavin D Laing; R David G Theakston; José María Gutiérrez; Teresa Escalante; Paola Zigrino; Ana Maria Moura da Silva; Roswitha Nischt; Cornelia Mauch; Christopher A Moskaluk; Jay W Fox
Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: in vitro and in vivo gene expression analysis of the effects of the toxin.
Archives of biochemistry and biophysics 2005;441(1):1-15.
2005: JM Howes; Aura S Kamiguti; R David G Theakston; Mark C Wilkinson; Gavin D Laing
Effects of three novel metalloproteinases from the venom of the West African saw-scaled viper, Echis ocellatus on blood coagulation and platelets.
Biochimica et biophysica acta 2005;1724(1-2):194-202.
2005: José María Gutiérrez; Ermila Rojas; Lil Quesada; Guillermo León; J Núñez; Gavin D Laing; M Sasa; Juan M Renjifo; A Nasidi; David A Warrell; R David G Theakston; Gustavo Rojas
Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2005;99(6):468-75.
2005: JM Howes; R David G Theakston; Gavin D Laing
Antigenic relationships and relative immunogenicities of isolated metalloproteinases from Echis ocellatus venom.
Toxicon : official journal of the International Society on Toxinology 2005;45(5):677-80.
2004: Roger Smalligan; Judy Cole; Narcissa Brito; Gavin D Laing; Bruce L Mertz; Steven Manock; Jeffrey Maudlin; Brad Quist; Gary Holland; Stephen Nelson; David Lalloo; Gonzalo Rivadeneira; Maria Elena Barragan; Daniel Dolley; Michael Eddleston; David A Warrell; R David G Theakston
Crotaline snake bite in the Ecuadorian Amazon: randomised double blind comparative trial of three South American polyspecific antivenoms.
BMJ (Clinical research ed.) 2004;329(7475):1129.
2004: Markus Schneemann; Richard Cathomas; S T Laidlaw; A M El Nahas; R David G Theakston; D A Warrell
Life-threatening envenoming by the Saharan horned viper (Cerastes cerastes) causing micro-angiopathic haemolysis, coagulopathy and acute renal failure: clinical cases and review.
QJM : monthly journal of the Association of Physicians 2004;97(11):717-27.
2004: SS Hasson; R David G Theakston; Robert A Harrison
Antibody zymography: a novel adaptation of zymography to determine the protease-neutralising potential of specific antibodies and snake antivenoms.
Journal of immunological methods 2004;292(1-2):131-9.
2004: Miguel Tanús Jorge; C Malaque; Lindioneza Adriano Ribeiro; Hui Wen Fan; João Luiz Costa Cardoso; Sérgio A Nishioka; Ida Sigueko Sano-Martins; Francisco O S França; Aura S Kamiguti; R David G Theakston; David A Warrell
Failure of chloramphenicol prophylaxis to reduce the frequency of abscess formation as a complication of envenoming by Bothrops snakes in Brazil: a double-blind randomized controlled trial.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2004;98(9):529-34.
2004: Gavin D Laing; A Yarleque; A Marcelo; E Rodriguez; David A Warrell; R David G Theakston
Preclinical testing of three South American antivenoms against the venoms of five medically-important Peruvian snake venoms.
Toxicon : official journal of the International Society on Toxinology 2004;44(1):103-6.
2004: Stanislawa Bazan-Socha; Dariusz G Kisiel; Brad Young; R David G Theakston; Juan J Calvete; Dean Sheppard; Cezary Marcinkiewicz
Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins.
Biochemistry 2004;43(6):1639-47.
2004: Teresa Escalante; Alexandra Rucavado; Aura S Kamiguti; R David G Theakston; José María Gutiérrez
Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy.
Toxicon : official journal of the International Society on Toxinology 2004;43(2):213-7.
2004: Pedro Pereira de Oliveira Pardal; Suzana Medeiro Souza; Maria Rita de Cassia Costa Monteiro; Hui Wen Fan; João Luiz Costa Cardoso; Francisco O S França; Sandra Corrallo Tomy; Ida Sigueko Sano-Martins; Maria Cristina Cirillo de Sousa-e-Silva; Mônica Colombini; Nancy F Kodera; Ana Maria Moura da Silva; Diva Ferreira Cardoso; David Toledo Velarde; Aura S Kamiguti; R David G Theakston; David A Warrell
Clinical trial of two antivenoms for the treatment of Bothrops and Lachesis bites in the north eastern Amazon region of Brazil.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2004;98(1):28-42.
2003: Gavin D Laing; Patricia Bianca Clissa; R David G Theakston; Ana Maria Moura da Silva; Mark John Taylor
Inflammatory pathogenesis of snake venom metalloproteinase-induced skin necrosis.
European journal of immunology 2003;33(12):3458-63.
2003: Teresa Escalante; Javier Núñez; Ana Maria Moura da Silva; Alexandra Rucavado; R David G Theakston; José María Gutiérrez
Pulmonary hemorrhage induced by jararhagin, a metalloproteinase from Bothrops jararaca snake venom.
Toxicology and applied pharmacology 2003;193(1):17-28.
2003: SS Hasson; R David G Theakston; Robert A Harrison
Cloning of a prothrombin activator-like metalloproteinase from the West African saw-scaled viper, Echis ocellatus.
Toxicon : official journal of the International Society on Toxinology 2003;42(6):629-34.
2003: Robert A Harrison; J Oliver; SS Hasson; K Bharati; R David G Theakston
Novel sequences encoding venom C-type lectins are conserved in phylogenetically and geographically distinct Echis and Bitis viper species.
Gene 2003;315():95-102.
2003: Leandra Watanabe; John D Shannon; Richard H Valente; Alexandra Rucavado; Alberto Alape-Girón; Aura S Kamiguti; R David G Theakston; Jay W Fox; José María Gutiérrez; Raghuvir K Arni
Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities.
Protein science : a publication of the Protein Society 2003;12(10):2273-81.
2003: Gilbert D Loría; Alexandra Rucavado; Aura S Kamiguti; R David G Theakston; Jay W Fox; Alberto Alape; José María Gutiérrez
Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis.
Archives of biochemistry and biophysics 2003;418(1):13-24.
2003: I Birgitta Sundell; M Rånby; Mirko Zuzel; K A Robinson; R David G Theakston
In vitro procoagulant and anticoagulant properties of Naja naja naja venom.
Toxicon : official journal of the International Society on Toxinology 2003;42(3):239-47.
2003: Aura S Kamiguti; Paul Gallagher; Cezary Marcinkiewicz; R David G Theakston; Mirko Zuzel; Jay W Fox
Identification of sites in the cysteine-rich domain of the class P-III snake venom metalloproteinases responsible for inhibition of platelet function.
FEBS letters 2003;549(1-3):129-34.
2003: Gavin D Laing; Juan M Renjifo; F Ruiz; Robert A Harrison; A Nasidi; J-M Gutierrez; P D Rowley; David A Warrell; R David G Theakston
A new Pan African polyspecific antivenom developed in response to the antivenom crisis in Africa.
Toxicon : official journal of the International Society on Toxinology 2003;42(1):35-41.
2003: JM Howes; Mark C Wilkinson; R David G Theakston; Gavin D Laing
The purification and partial characterisation of two novel metalloproteinases from the venom of the West African carpet viper, Echis ocellatus.
Toxicon : official journal of the International Society on Toxinology 2003;42(1):21-7.
2003: Juan J Calvete; M Paz Moreno-Murciano; R David G Theakston; Dariusz G Kisiel; Cezary Marcinkiewicz
Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering.
The Biochemical journal 2003;372(Pt 3):725-34.
2003: K Bharati; SS Hasson; J Oliver; Gavin D Laing; R David G Theakston; Robert A Harrison
Molecular cloning of phospholipases A(2) from venom glands of Echis carpet vipers.
Toxicon : official journal of the International Society on Toxinology 2003;41(8):941-7.
2003: Francisco O S França; Katia Cristina Barbaro; Hui Wen Fan; João Luiz Costa Cardoso; Ida Sigueko Sano-Martins; Sandra Corrallo Tomy; M H Lopes; David A Warrell; R David G Theakston
Envenoming by Bothrops jararaca in Brazil: association between venom antigenaemia and severity at admission to hospital.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2003;97(3):312-7.
2003: R David G Theakston; David A Warrell; E Griffiths
Report of a WHO workshop on the standardization and control of antivenoms.
Toxicon : official journal of the International Society on Toxinology 2003;41(5):541-57.
2003: Anna M Molesworth; Robert Harrison; R David G Theakston; David Lalloo
Geographic Information System mapping of snakebite incidence in northern Ghana and Nigeria using environmental indicators: a preliminary study.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2003;97(2):188-92.
2003: I Birgitta Sundell; Khalil A Aziz; Mirko Zuzel; R David G Theakston
The role of phospholipases A2 in the stimulation of neutrophil motility by cobra venoms.
Toxicon : official journal of the International Society on Toxinology 2003;41(4):459-68.
2003: Robert A Harrison; W Wüster; R David G Theakston
The conserved structure of snake venom toxins confers extensive immunological cross-reactivity to toxin-specific antibody.
Toxicon : official journal of the International Society on Toxinology 2003;41(4):441-9.
2003: Paul G Gallagher; Yongde Bao; Solange M T Serrano; Aura S Kamiguti; R David G Theakston; Jay W Fox
Use of microarrays for investigating the subtoxic effects of snake venoms: insights into venom-induced apoptosis in human umbilical vein endothelial cells.
Toxicon : official journal of the International Society on Toxinology 2003;41(4):429-40.
2003: Gavin D Laing; Robert A Harrison; R David G Theakston; Juan M Renjifo; A Nasidi; J M Gutierrez; David A Warrell
Polyspecific snake antivenom may help in antivenom crisis.
BMJ (Clinical research ed.) 2003;326(7386):447.
2003: David Lalloo; R David G Theakston
Snake antivenoms.
Journal of toxicology. Clinical toxicology 2003;41(3):277-90; 317-27.
2002: Leandra Watanabe; Alexandra Rucavado; Aura S Kamiguti; R David G Theakston; José María Gutiérrez; Raghuvir K Arni
Crystallization and preliminary diffraction data of BaP1, a haemorrhagic metalloproteinase from Bothrops asper snake venom.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 6 Pt 2):1034-5.
2002: R David G Theakston; Aura S Kamiguti
A list of animal toxins and some other natural products with biological activity.
Toxicon : official journal of the International Society on Toxinology 2002;40(5):579-651.
2002: David Lalloo; R David G Theakston; David A Warrell
The African challenge.
Lancet 2002;359(9316):1527.
2002: Robert A Harrison; A Richards; Gavin D Laing; R David G Theakston
Simultaneous GeneGun immunisation with plasmids encoding antigen and GM-CSF: significant enhancement of murine antivenom IgG1 titres.
Vaccine 2002;20(13-14):1702-6.
2002: J Bryan Smith; R David G Theakston; Ana Lúcia J Coelho; Christina Barja-Fidalgo; Juan J Calvete; Cezary Marcinkiewicz
Characterization of a monomeric disintegrin, ocellatusin, present in the venom of the Nigerian carpet viper, Echis ocellatus.
FEBS letters 2002;512(1-3):111-5.
2001: Ida Sigueko Sano-Martins; Sandra Corrallo Tomy; D Campolina; MB Dias; S C de Castro; Maria Cristina Cirillo de Sousa-e-Silva; Carlos Faria Santos Amaral; Nilton Alves de Rezende; Aura S Kamiguti; David A Warrell; R David G Theakston
Coagulopathy following lethal and non-lethal envenoming of humans by the South American rattlesnake (Crotalus durissus) in Brazil.
QJM : monthly journal of the Association of Physicians 2001;94(10):551-9.
2001: Patricia Bianca Clissa; Gavin D Laing; R David G Theakston; I Mota; M J Taylor; Ana Maria Moura da Silva
The effect of jararhagin, a metalloproteinase from Bothrops jararaca venom, on pro-inflammatory cytokines released by murine peritoneal adherent cells.
Toxicon : official journal of the International Society on Toxinology 2001;39(10):1567-73.
2001: I Birgitta Sundell; R David G Theakston; Aura S Kamiguti; Robert J Harris; Andrew T Treweeke; Gavin D Laing; Jay W Fox; David A Warrell; Mirko Zuzel
The inhibition of platelet aggregation and blood coagulation by Micropechis ikaheka venom.
British journal of haematology 2001;114(4):852-60.
2001: Robert K Andrews; Aura S Kamiguti; Oscar Berlanga; Mireille Leduc; R David G Theakston; Steve P Watson
The use of snake venom toxins as tools to study platelet receptors for collagen and von Willebrand factor.
Haemostasis 2001;31(3-6):155-72.
2001: Paula G Sells; Gavin D Laing; R David G Theakston
An in vivo but insensate model for the evaluation of antivenoms (ED(50)) using fertile hens' eggs.
Toxicon : official journal of the International Society on Toxinology 2001;39(5):665-8.
2001: Alexandra Rucavado; M Soto; Aura S Kamiguti; R David G Theakston; Jay W Fox; Teresa Escalante; José María Gutiérrez
Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage.
Thrombosis and haemostasis 2001;85(4):710-5.
2001: CA Ariaratnam; L Sjöström; Z Raziek; S A Kularatne; R W Arachchi; M H Rezvi Sheriff; R David G Theakston; David A Warrell
An open, randomized comparative trial of two antivenoms for the treatment of envenoming by Sri Lankan Russell's viper (Daboia russelii russelii).
Transactions of the Royal Society of Tropical Medicine and Hygiene 2001;95(1):74-80.
2000: Aura S Kamiguti; R David G Theakston; N Sherman; Jay W Fox
Mass spectrophotometric evidence for P-III/P-IV metalloproteinases in the venom of the Boomslang (Dispholidus typus).
Toxicon : official journal of the International Society on Toxinology 2000;38(11):1613-20.
2000: Robert A Harrison; Ana Maria Moura da Silva; Gavin D Laing; Yang Wu; A Richards; A Broadhead; Albert E Bianco; R David G Theakston
Antibody from mice immunized with DNA encoding the carboxyl-disintegrin and cysteine-rich domain (JD9) of the haemorrhagic metalloprotease, Jararhagin, inhibits the main lethal component of viper venom.
Clinical and experimental immunology 2000;121(2):358-63.
2000: I Hers; Oscar Berlanga; M J Tiekstra; Aura S Kamiguti; R David G Theakston; Steve P Watson
Evidence against a direct role of the integrin alpha2beta1 in collagen-induced tyrosine phosphorylation in human platelets.
European journal of biochemistry / FEBS 2000;267(7):2088-97.
2000: Aura S Kamiguti; R David G Theakston; S P Watson; C Bon; Gavin D Laing; Mirko Zuzel
Distinct contributions of glycoprotein VI and alpha(2)beta(1) integrin to the induction of platelet protein tyrosine phosphorylation and aggregation.
Archives of biochemistry and biophysics 2000;374(2):356-62.
1999: Ana Maria Moura da Silva; A Línica; Maisa S Della-Casa; Aura S Kamiguti; P L Ho; Julian M Crampton; R David G Theakston
Jararhagin ECD-containing disintegrin domain: expression in escherichia coli and inhibition of the platelet-collagen interaction.
Archives of biochemistry and biophysics 1999;369(2):295-301.
1999: CA Ariaratnam; WP Meyer; G Perera; Michael Eddleston; S A Kuleratne; W Attapattu; Rezvi Sheriff; A M Richards; R David G Theakston; David A Warrell
A new monospecific ovine Fab fragment antivenom for treatment of envenoming by the Sri Lankan Russell's viper (Daboia Russelii Russelii): a preliminary dose-finding and pharmacokinetic study.
The American journal of tropical medicine and hygiene 1999;61(2):259-65.
1999: Hui Wen Fan; L F Marcopito; João Luiz Costa Cardoso; Francisco O S França; C M Malaque; R A Ferrari; R David G Theakston; David A Warrell
Sequential randomised and double blind trial of promethazine prophylaxis against early anaphylactic reactions to antivenom for bothrops snake bites.
BMJ (Clinical research ed.) 1999;318(7196):1451-2.
1998: Aura S Kamiguti; Mirko Zuzel; R David G Theakston
Snake venom metalloproteinases and disintegrins: interactions with cells.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1998;31(7):853-62.
1998: Paula G Sells; P Ioannou; R David G Theakston
A humane alternative to the measurement of the lethal effects (LD50) of non-neurotoxic venoms using hens' eggs.
Toxicon : official journal of the International Society on Toxinology 1998;36(7):985-91.
1997: Aura S Kamiguti; F S Markland; Q Zhou; Gavin D Laing; R David G Theakston; Mirko Zuzel
Proteolytic cleavage of the beta1 subunit of platelet alpha2beta1 integrin by the metalloproteinase jararhagin compromises collagen-stimulated phosphorylation of pp72.
The Journal of biological chemistry 1997;272(51):32599-605.
1997: R David G Theakston
An objective approach to antivenom therapy and assessment of first-aid measures in snake bite.
Annals of tropical medicine and parasitology 1997;91(7):857-65.
1997: Paula G Sells; A M Richards; Gavin D Laing; R David G Theakston
The use of hens' eggs as an alternative to the conventional in vivo rodent assay for antidotes to haemorrhagic venoms.
Toxicon : official journal of the International Society on Toxinology 1997;35(9):1413-21.
1997: Ida Sigueko Sano-Martins; Marcelo Larami Santoro; S C Castro; Hui Wen Fan; João Luiz Costa Cardoso; R David G Theakston
Platelet aggregation in patients bitten by the Brazilian snake Bothrops jararaca.
Thrombosis research 1997;87(2):183-95.
1997: R David G Theakston; D C Smith
Antivenoms.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 1997;7(5):366-75.
1997: R Milani Júnior; Miguel Tanús Jorge; F P de Campos; F P Martins; Albert Bousso; João Luiz Costa Cardoso; Lindioneza Adriano Ribeiro; Hui Wen Fan; Francisco O S França; Ida Sigueko Sano-Martins; Diva Ferreira Cardoso; C Ide Fernandez; J C Fernandes; V L Aldred; M P Sandoval; G Puorto; R David G Theakston; David A Warrell
Snake bites by the jararacuçu (Bothrops jararacussu): clinicopathological studies of 29 proven cases in São Paulo State, Brazil.
QJM : monthly journal of the Association of Physicians 1997;90(5):323-34.
1997: Aura S Kamiguti; Ana Maria Moura da Silva; Gavin D Laing; T Knapp; Mirko Zuzel; Julian M Crampton; R David G Theakston
Collagen-induced secretion-dependent phase of platelet aggregation is inhibited by the snake venom metalloproteinase jararhagin.
Biochimica et biophysica acta 1997;1335(1-2):209-17.
1997: WP Meyer; A G Habib; A A Onayade; A Yakubu; D C Smith; A Nasidi; I J Daudu; David A Warrell; R David G Theakston
First clinical experiences with a new ovine Fab Echis ocellatus snake bite antivenom in Nigeria: randomized comparative trial with Institute Pasteur Serum (Ipser) Africa antivenom.
The American journal of tropical medicine and hygiene 1997;56(3):291-300.
1996: Ana Maria Moura da Silva; Gavin D Laing; Mark Paine; J M Dennison; V Politi; J M Crampton; R David G Theakston
Processing of pro-tumor necrosis factor-alpha by venom metalloproteinases: a hypothesis explaining local tissue damage following snake bite.
European journal of immunology 1996;26(9):2000-5.
1996: Ana Maria Moura da Silva; R David G Theakston; J M Crampton
Evolution of disintegrin cysteine-rich and mammalian matrix-degrading metalloproteinases: gene duplication and divergence of a common ancestor rather than convergent evolution.
Journal of molecular evolution 1996;43(3):263-9.
1996: Aura S Kamiguti; C R Hay; R David G Theakston; Mirko Zuzel
Insights into the mechanism of haemorrhage caused by snake venom metalloproteinases.
Toxicon : official journal of the International Society on Toxinology 1996;34(6):627-42.
1996: David Lalloo; AJ Trevett; J Black; J Mapao; A Saweri; S Naraqi; D Owens; Aura S Kamiguti; R A Hutton; R David G Theakston; David A Warrell
Neurotoxicity, anticoagulant activity and evidence of rhabdomyolysis in patients bitten by death adders (Acanthophis sp.) in southern Papua New Guinea.
QJM : monthly journal of the Association of Physicians 1996;89(1):25-35.
1995: R David G Theakston; David A Warrell
1st International Congress on Envenomations and their Treatments Institut Pasteur, Paris, 7-9 June, 1995.
Biologicals : journal of the International Association of Biological Standardization 1995;23(4):327-30.
1995: R David G Theakston; Gavin D Laing; C M Fielding; A F Lascano; J M Touzet; F Vallejo; R H Guderian; S J Nelson; W Wüster; A M Richards
Treatment of snake bites by Bothrops species and Lachesis muta in Ecuador: laboratory screening of candidate antivenoms.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1995;89(5):550-4.
1995: Ana Maria Moura da Silva; Mark Paine; M R Diniz; R David G Theakston; J M Crampton
The molecular cloning of a phospholipase A2 from Bothrops jararacussu snake venom: evolution of venom group II phospholipase A2's may imply gene duplications.
Journal of molecular evolution 1995;41(2):174-9.
1995: Gavin D Laing; Aura S Kamiguti; M C Wilkinson; G M Lowe; R David G Theakston
Characterisation of a purified phospholipase A2 from the venom of the Papuan black snake (Pseudechis papuanus).
Biochimica et biophysica acta 1995;1250(2):137-43.
1995: AJ Trevett; David Lalloo; N C Nwokolo; S Naraqi; I H Kevau; R David G Theakston; David A Warrell
Failure of 3,4-diaminopyridine and edrophonium to produce significant clinical benefit in neurotoxicity following the bite of Papuan taipan (Oxyuranus scutellatus canni).
Transactions of the Royal Society of Tropical Medicine and Hygiene 1995;89(4):444-6.
1995: AJ Trevett; David Lalloo; N C Nwokolo; S Naraqi; I H Kevau; R David G Theakston; David A Warrell
Electrophysiological findings in patients envenomed following the bite of a Papuan taipan (Oxyuranus scutellatus canni).
Transactions of the Royal Society of Tropical Medicine and Hygiene 1995;89(4):415-7.
1995: AJ Trevett; David Lalloo; N C Nwokolo; S Naraqi; I H Kevau; R David G Theakston; David A Warrell
The efficacy of antivenom in the treatment of bites by the Papuan taipan (Oxyuranus scutellatus canni).
Transactions of the Royal Society of Tropical Medicine and Hygiene 1995;89(3):322-5.
1995: David Lalloo; AJ Trevett; A Saweri; S Naraqi; R David G Theakston; David A Warrell
The epidemiology of snake bite in Central Province and National Capital District, Papua New Guinea.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1995;89(2):178-82.
1995: Gavin D Laing; L Lee; D C Smith; J Landon; R David G Theakston
Experimental assessment of a new, low-cost antivenom for treatment of carpet viper (Echis ocellatus) envenoming.
Toxicon : official journal of the International Society on Toxinology 1995;33(3):307-13.
1995: David Lalloo; AJ Trevett; D Owens; J Minei; S Naraqi; A Saweri; R A Hutton; R David G Theakston; David A Warrell
Coagulopathy following bites by the Papuan taipan (Oxyuranus scutellatus canni).
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1995;6(1):65-72.
1994: Paula G Sells; R David G Theakston; David A Warrell
Development of alpha-neurotoxin antibodies in patients envenomed by the monocellate Thai cobra (Naja kaouthia).
Toxicon : official journal of the International Society on Toxinology 1994;32(12):1667-71.
1994: Paula G Sells; Russell G.A. Jones; Gavin D Laing; D C Smith; R David G Theakston
Experimental evaluation of ovine antisera to Thai cobra (Naja kaouthia) venom and its alpha-neurotoxin.
Toxicon : official journal of the International Society on Toxinology 1994;32(12):1657-65.
1994: M O Domingos; H A Takehara; Gavin D Laing; K F Snowden; Paula G Sells; I Mota; R David G Theakston
Detection and neutralization of B. jararaca venom in mice.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(11):2613-22.
1994: Mark Paine; Ana Maria Moura da Silva; R David G Theakston; J M Crampton
Cloning of metalloprotease genes in the carpet viper (Echis pyramidum leakeyi). Further members of the metalloprotease/disintegrin gene family.
European journal of biochemistry / FEBS 1994;224(2):483-8.
1994: Ida Sigueko Sano-Martins; Hui Wen Fan; S C Castro; S C Tomy; F O Franca; Miguel Tanús Jorge; Aura S Kamiguti; David A Warrell; R David G Theakston
Reliability of the simple 20 minute whole blood clotting test (WBCT20) as an indicator of low plasma fibrinogen concentration in patients envenomed by Bothrops snakes. Butantan Institute Antivenom Study Group.
Toxicon : official journal of the International Society on Toxinology 1994;32(9):1045-50.
1994: Aura S Kamiguti; H P Desmond; R David G Theakston; C R Hay; Mirko Zuzel
Ineffectiveness of the inhibition of the main haemorrhagic metalloproteinase from Bothrops jararaca venom by its only plasma inhibitor, alpha 2-macroglobulin.
Biochimica et biophysica acta 1994;1200(3):307-14.
1994: David Lalloo; AJ Trevett; J Black; J Mapao; S Naraqi; D Owens; R Hutton; R David G Theakston; David A Warrell
Neurotoxicity and haemostatic disturbances in patients envenomed by the Papuan black snake (Pseudechis papuanus).
Toxicon : official journal of the International Society on Toxinology 1994;32(8):927-36.
1994: Aura S Kamiguti; Gavin D Laing; G M Lowe; Mirko Zuzel; David A Warrell; R David G Theakston
Biological properties of the venom of the Papuan black snake (Pseudechis papuanus): presence of a phospholipase A2 platelet inhibitor.
Toxicon : official journal of the International Society on Toxinology 1994;32(8):915-25.
1994: Francisco O S França; Luiz Alberto Benvenuti; Hui Wen Fan; D R Dos Santos; Huei Hsin Shieh; F R Picchi-Martins; João Luiz Costa Cardoso; Aura S Kamiguti; R David G Theakston; David A Warrell
Severe and fatal mass attacks by 'killer' bees (Africanized honey bees--Apis mellifera scutellata) in Brazil: clinicopathological studies with measurement of serum venom concentrations.
The Quarterly journal of medicine 1994;87(5):269-82.
1993: M R Diniz; Mark Paine; Carlos R Diniz; R David G Theakston; J M Crampton
Sequence of the cDNA coding for the lethal neurotoxin Tx1 from the Brazilian "armed" spider Phoneutria nigriventer predicts the synthesis and processing of a preprotoxin.
The Journal of biological chemistry 1993;268(21):15340-2.
1993: Gavin D Laing; R David G Theakston
Immunization against Echis ocellatus (carpet viper) venom using liposomes incorporating immunostimulants: role of lipopolysaccharide in conferring protection in a mouse model.
Toxicon : official journal of the International Society on Toxinology 1993;31(5):615-26.
1992: Mark Paine; H P Desmond; R David G Theakston; J M Crampton
Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family.
The Journal of biological chemistry 1992;267(32):22869-76.
1992: R David G Theakston; Hui Wen Fan; David A Warrell; Wilmar Dias da Silva; Stephen A Ward; H G Higashi
Use of enzyme immunoassays to compare the effect and assess the dosage regimens of three Brazilian Bothrops antivenoms. The Butantan Institute Antivenom Study Group (BIASG).
The American journal of tropical medicine and hygiene 1992;47(5):593-604.
1992: Gavin D Laing; R David G Theakston; R P Leite; Wilmar Dias da Silva; David A Warrell
Comparison of the potency of three Brazilian Bothrops antivenoms using in vivo rodent and in vitro assays. BIASG (Butantan Institute Antivenom Study Group).
Toxicon : official journal of the International Society on Toxinology 1992;30(10):1219-25.
1992: Aura S Kamiguti; F P Rugman; R David G Theakston; F O Franca; H Ishii; C R Hay
The role of venom haemorrhagin in spontaneous bleeding in Bothrops jararaca envenoming. Butantan Institute Antivenom Study Group.
Thrombosis and haemostasis 1992;67(4):484-8.
1992: Mark Paine; H P Desmond; R David G Theakston; J M Crampton
Gene expression in Echis carinatus (carpet viper) venom glands following milking.
Toxicon : official journal of the International Society on Toxinology 1992;30(4):379-86.
1991: Aura S Kamiguti; João Luiz Costa Cardoso; R David G Theakston; Ida Sigueko Sano-Martins; R A Hutton; F P Rugman; David A Warrell; C R Hay
Coagulopathy and haemorrhage in human victims of Bothrops jararaca envenoming in Brazil.
Toxicon : official journal of the International Society on Toxinology 1991;29(8):961-72.
1991: Ana Maria Moura da Silva; H Desmond; Gavin D Laing; R David G Theakston
Isolation and comparison of myotoxins isolated from venoms of different species of Bothrops snakes.
Toxicon : official journal of the International Society on Toxinology 1991;29(6):713-23.
1991: H P Desmond; J M Crampton; R David G Theakston
Rapid isolation and partial characterization of two phospholipases from Kenyan Echis carinatus leakeyi (Leakey's saw-scaled viper) venom.
Toxicon : official journal of the International Society on Toxinology 1991;29(4-5):536-9.
1991: R David G Theakston; David A Warrell
Antivenoms: a list of hyperimmune sera currently available for the treatment of envenoming by bites and stings.
Toxicon : official journal of the International Society on Toxinology 1991;29(12):1419-70.
1991: Aura S Kamiguti; R David G Theakston; H Desmond; R A Hutton
Systemic haemorrhage in rats induced by a haemorrhagic fraction from Bothrops jararaca venom.
Toxicon : official journal of the International Society on Toxinology 1991;29(9):1097-105.
1990: R David G Theakston; R E Phillips; S Looareesuwan; P Echeverria; T Makin; David A Warrell
Bacteriological studies of the venom and mouth cavities of wild Malayan pit vipers (Calloselasma rhodostoma) in southern Thailand.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1990;84(6):875-9.
1990: João Luiz Costa Cardoso; F H Wen; Francisco O S França; David A Warrell; R David G Theakston
Detection by enzyme immunoassay of Loxosceles gaucho venom in necrotic skin lesions caused by spider bites in Brazil.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1990;84(4):608-9.
1990: R David G Theakston; R E Phillips; David A Warrell; Y Galagedera; D T Abeysekera; P Dissanayaka; A de Silva; D J Aloysius
Envenoming by the common krait (Bungarus caeruleus) and Sri Lankan cobra (Naja naja naja): efficacy and complications of therapy with Haffkine antivenom.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1990;84(2):301-8.
1990: F P Rugman; S N Cottam; R David G Theakston
A bite by a carpet viper (Echis carinatus) in a research institute.
Clinical and laboratory haematology 1990;12(2):221-8.
1989: R David G Theakston
Snake venoms in science and clinical medicine. 2. Applied immunology in snake venom research.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1989;83(6):741-4.
1989: R David G Theakston
New techniques in antivenom production and active immunization against snake venoms.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1989;83(4):433-5.
1989: T V Freitas; A P Tavares; R David G Theakston; G Laing; Roger New
Use of liposomes for protective immunisation against Crotalus durissus (tropical rattlesnake) venom.
Toxicon : official journal of the International Society on Toxinology 1989;27(3):341-7.
1989: Paula G Sells; M Hommel; R David G Theakston
Venom production in snake venom gland cells cultured in vitro.
Toxicon : official journal of the International Society on Toxinology 1989;27(11):1245-9.
1988: Aura S Kamiguti; R David G Theakston; S C Tomy
An investigation of the coagulant activity of the venom of the saw-scaled viper (Echis carinatus) from Saudi Arabia.
Annals of tropical medicine and parasitology 1988;82(5):503-9.
1988: R E Phillips; R David G Theakston; David A Warrell; Y Galigedara; D T Abeysekera; P Dissanayaka; R A Hutton; D J Aloysius
Paralysis, rhabdomyolysis and haemolysis caused by bites of Russell's viper (Vipera russelli pulchella) in Sri Lanka: failure of Indian (Haffkine) antivenom.
The Quarterly journal of medicine 1988;68(257):691-715.
1988: I Daudu; R David G Theakston
Preliminary trial of a new polyspecific antivenom in Nigeria.
Annals of tropical medicine and parasitology 1988;82(3):311-3.
1988: D Iddon; M Hommel; R David G Theakston
Characterisation of a monoclonal antibody capable of neutralising the haemorrhagic activity of West African Echis carinatus (carpet viper) venom.
Toxicon : official journal of the International Society on Toxinology 1988;26(2):167-79.
1987: R N Pugh; R David G Theakston
A clinical study of viper bite poisoning.
Annals of tropical medicine and parasitology 1987;81(2):135-49.
1987: R N Pugh; R David G Theakston
Fatality following use of a tourniquet after viper bite envenoming.
Annals of tropical medicine and parasitology 1987;81(1):77-8.
1987: R N Pugh; R David G Theakston
Antivenom reactions and complement depletion in snake bite.
Annals of tropical medicine and parasitology 1987;81(1):73-5.
1987: D Iddon; R David G Theakston; C L Ownby
A study of the pathogenesis of local skin necrosis induced by Naja nigricollis (spitting cobra) venom using simple histological staining techniques.
Toxicon : official journal of the International Society on Toxinology 1987;25(6):665-72.
1986: David A Warrell; Sornchai Looareesuwan; R David G Theakston; R E Phillips; Pornthep Chanthavanich; C Viravan; Wichai Supanaranond; Juntra Karbwang; M Ho; R A Hutton
Randomized comparative trial of three monospecific antivenoms for bites by the Malayan pit viper (Calloselasma rhodostoma) in southern Thailand: clinical and laboratory correlations.
The American journal of tropical medicine and hygiene 1986;35(6):1235-47.
1986: R E Phillips; David A Warrell; G Edwards; Y Galagedera; R David G Theakston; D T Abeysekera; P Dissanayaka
Divided dose intramuscular regimen and single dose subcutaneous regimen for chloroquine: plasma concentrations and toxicity in patients with malaria.
British medical journal (Clinical research ed.) 1986;293(6538):13-6.
1986: D Iddon; R David G Theakston
Biological properties of the venom of the red-necked keel-back snake (Rhabdophis subminiatus).
Annals of tropical medicine and parasitology 1986;80(3):339-44.
1986: D Taylor; D Iddon; Paula G Sells; S Semoff; R David G Theakston
An investigation of venom secretion by the venom gland cells of the carpet viper (Echis carinatus).
Toxicon : official journal of the International Society on Toxinology 1986;24(7):651-9.
1985: R David G Theakston; O Zumbuehl; Roger New
Use of liposomes for protective immunisation in sheep against Echis carinatus snake venom.
Toxicon : official journal of the International Society on Toxinology 1985;23(6):921-5.
1985: Roger New; R David G Theakston; O Zumbuehl; D Iddon; J Friend
Liposomal immunisation against snake venoms.
Toxicon : official journal of the International Society on Toxinology 1985;23(2):215-9.
1984: Roger New; R David G Theakston; O Zumbuhl; D Iddon; J Friend
Immunization against snake venoms.
The New England journal of medicine 1984;311(1):56-7.
1983: R David G Theakston; H A Reid; D Iddon; J W Larrick
Protective effect of snake venom antibodies in sera of previous snake bite victims.
Annals of tropical medicine and parasitology 1983;77(3):311-4.
1983: D A Warrell; S Looareesuwan; N J White; R David G Theakston; MARY WARRELL; W Kosakarn; H A Reid
Severe neurotoxic envenoming by the Malayan krait Bungarus candidus (Linnaeus): response to antivenom and anticholinesterase.
British medical journal (Clinical research ed.) 1983;286(6366):678-80.
1983: R David G Theakston; H A Reid
Development of simple standard assay procedures for the characterization of snake venom.
Bulletin of the World Health Organization 1983;61(6):949-56.
1983: H A Reid; R David G Theakston
The management of snake bite.
Bulletin of the World Health Organization 1983;61(6):885-95.
1981: R David G Theakston; H A Reid; J W Larrick; J Kaplan; J A Yost
Snake venom antibodies in Ecuadorian Indians.
The Journal of tropical medicine and hygiene 1981;84(5):199-202.
1981: R David G Theakston; R N Pugh; H A Reid
Enzyme-linked immunosorbent assay of venom-antibodies in human victims of snake bite.
The Journal of tropical medicine and hygiene 1981;84(3):109-12.
1980: R N Pugh; R David G Theakston; H A Reid
Malumfashi Endemic Diseases Research Project, XIII. Epidemiology of human encounters with the spitting cobra, Naja nigricollis, in the Malumfashi area of northern Nigeria.
Annals of tropical medicine and parasitology 1980;74(5):523-30.