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Irma Thesleff

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
18
Aberg, Thomas
17
Jernvall, Jukka
17
Mikkola, Marja
15
Sahlberg, Carin
14
Kettunen, Päivi
13
Pispa, Johanna
13
Nieminen, Pekka
11
Tummers, Mark
10
Rice, David
10
Mustonen, Tuija
10
Laurikkala, Johanna
9
Järvinen, Elina
8
Lukinmaa, Pirjo-Liisa
8
Jalkanen, Markku
8
Rice, Ritva

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Publications

TOP 3
Takatalo M S; Tummers M; Thesleff I; Rönnholm R
Novel Golgi protein, GoPro49, is a specific dental follicle marker.
Tummers Mark; Thesleff Irma
The importance of signal pathway modulation in all aspects of tooth development.
Järvinen Elina; Tummers Mark; Thesleff Irma
The role of the dental lamina in mammalian tooth replacement.

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All Publications

2009: Takatalo M S; Tummers M; Thesleff I; Rönnholm R
Novel Golgi protein, GoPro49, is a specific dental follicle marker.
Journal of dental research 2009;88(6):534-8.
2009: Tummers Mark; Thesleff Irma
The importance of signal pathway modulation in all aspects of tooth development.
Journal of experimental zoology. Part B, Molecular and developmental evolution 2009;312B(4):309-19.
2009: Järvinen Elina; Tummers Mark; Thesleff Irma
The role of the dental lamina in mammalian tooth replacement.
Journal of experimental zoology. Part B, Molecular and developmental evolution 2009;312B(4):281-91.
2009: Munne Pauliina M; Tummers Mark; Järvinen Elina; Thesleff Irma; Jernvall Jukka
Tinkering with the inductive mesenchyme: Sostdc1 uncovers the role of dental mesenchyme in limiting tooth induction.
Development (Cambridge, England) 2009;136(3):393-402.
2009: Charoenchaikorn Kesinee; Yokomizo Tomomasa; Rice David P; Honjo Tadashi; Matsuzaki Kiyomi; Shintaku Yuko; Imai Yuichi; Wakamatsu Asami; Takahashi Satoru; Ito Yoshiaki; Takano-Yamamoto Teruko; Thesleff Irma; Yamamoto Masayuki; Yamashiro Takashi
Runx1 is involved in the fusion of the primary and the secondary palatal shelves.
Developmental biology 2009;326(2):392-402.
2008: Pispa Johanna; Pummila Marja; Barker Philip A; Thesleff Irma; Mikkola Marja L
Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development.
Human molecular genetics 2008;17(21):3380-91.
2008: Zhang Fu-Ping; Mikkonen Laura; Toppari Jorma; Palvimo Jorma J; Thesleff Irma; Jänne Olli A
Sumo-1 function is dispensable in normal mouse development.
Molecular and cellular biology 2008;28(17):5381-90.
2008: Takatalo Maarit; Järvinen Elina; Laitinen Saara; Thesleff Irma; Rönnholm Ragna
Expression of the novel Golgi protein GoPro49 is developmentally regulated during mesenchymal differentiation.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(8):2243-55.
2008: Fliniaux Ingrid; Mikkola Marja L; Lefebvre Sylvie; Thesleff Irma
Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes.
Developmental biology 2008;320(1):60-71.
2008: Järvinen Elina; Välimäki Kaisa; Pummila Marja; Thesleff Irma; Jernvall Jukka
The taming of the shrew milk teeth.
Evolution & development 2008;10(4):477-86.
2008: Tummers Mark; Thesleff Irma
Observations on continuously growing roots of the sloth and the K14-Eda transgenic mice indicate that epithelial stem cells can give rise to both the ameloblast and root epithelium cell lineage creating distinct tooth patterns.
Evolution & development 2008;10(2):187-95.
2008: Närhi Katja; Järvinen Elina; Birchmeier Walter; Taketo Makoto M; Mikkola Marja L; Thesleff Irma
Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation.
Development (Cambridge, England) 2008;135(6):1019-28.
2008: Thesleff Irma; Sahlberg Carin
Organ culture in the analysis of tissue interactions.
Methods in molecular biology (Clifton, N.J.) 2008;461():23-30.
2007: Tummers M; Yamashiro T; Thesleff I
Modulation of epithelial cell fate of the root in vitro.
Journal of dental research 2007;86(11):1063-7.
2007: Kettunen Päivi; Spencer-Dene Bradley; Furmanek Tomasz; Kvinnsland Inger Hals; Dickson Clive; Thesleff Irma; Luukko Keijo
Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning.
Mechanisms of development 2007;124(11-12):868-83.
2007: Thesleff Irma; Wang Xiu-Ping; Suomalainen Marika
Regulation of epithelial stem cells in tooth regeneration.
Comptes rendus biologies 2007;330(6-7):561-4.
2007: Wang Xiu-Ping; Suomalainen Marika; Felszeghy Szabolcs; Zelarayan Laura C; Alonso Maria T; Plikus Maksim V; Maas Richard L; Chuong Cheng-Ming; Schimmang Thomas; Thesleff Irma
An integrated gene regulatory network controls stem cell proliferation in teeth.
PLoS biology 2007;5(6):e159.
2007: Yamashiro Takashi; Zheng Li; Shitaku Yuko; Saito Masahiro; Tsubakimoto Takanori; Takada Kenji; Takano-Yamamoto Teruko; Thesleff Irma
Wnt10a regulates dentin sialophosphoprotein mRNA expression and possibly links odontoblast differentiation and tooth morphogenesis.
Differentiation; research in biological diversity 2007;75(5):452-62.
2007: Pummila Marja; Fliniaux Ingrid; Jaatinen Risto; James Martyn J; Laurikkala Johanna; Schneider Pascal; Thesleff Irma; Mikkola Marja L
Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression.
Development (Cambridge, England) 2007;134(1):117-25.
2007: Thesleff Irma; Järvinen Elina; Suomalainen Marika
Affecting tooth morphology and renewal by fine-tuning the signals mediating cell and tissue interactions.
Novartis Foundation symposium 2007;284():142-53; discussion 153-63.
2006: Järvinen Elina; Salazar-Ciudad Isaac; Birchmeier Walter; Taketo Makoto M; Jernvall Jukka; Thesleff Irma
Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(49):18627-32.
2006: Thesleff Irma
The genetic basis of tooth development and dental defects.
American journal of medical genetics. Part A 2006;140(23):2530-5.
2006: James Martyn J; Järvinen Elina; Wang Xiu-Ping; Thesleff Irma
Different roles of Runx2 during early neural crest-derived bone and tooth development.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(7):1034-44.
2006: Laurikkala Johanna; Mikkola Marja L; James Martyn; Tummers Mark; Mills Alea A; Thesleff Irma
p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation.
Development (Cambridge, England) 2006;133(8):1553-63.
2005: Kassai Yoshiaki; Munne Pauliina; Hotta Yuhei; Penttilä Enni; Kavanagh Kathryn; Ohbayashi Norihiko; Takada Shinji; Thesleff Irma; Jernvall Jukka; Itoh Nobuyuki
Regulation of mammalian tooth cusp patterning by ectodin.
Science (New York, N.Y.) 2005;309(5743):2067-70.
2005: Rice Ritva; Thesleff Irma; Rice David P C
Regulation of Twist, Snail, and Id1 is conserved between the developing murine palate and tooth.
Developmental dynamics : an official publication of the American Association of Anatomists 2005;234(1):28-35.
2005: Løvschall H; Tummers M; Thesleff I; Füchtbauer E-M; Poulsen K
Activation of the Notch signaling pathway in response to pulp capping of rat molars.
European journal of oral sciences 2005;113(4):312-7.
2005: Rice Ritva; Rice David P C; Thesleff Irma
Foxc1 integrates Fgf and Bmp signalling independently of twist or noggin during calvarial bone development.
Developmental dynamics : an official publication of the American Association of Anatomists 2005;233(3):847-52.
2005: Aberg Thomas; Rice Ritva; Rice David; Thesleff Irma; Waltimo-Sirén Janna
Chondrogenic potential of mouse calvarial mesenchyme.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(5):653-63.
2005: Wang X-P; Aberg T; James M J; Levanon D; Groner Y; Thesleff I
Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth.
Journal of dental research 2005;84(2):138-43.
2004: Kangas Aapo T; Evans Alistair R; Thesleff Irma; Jernvall Jukka
Nonindependence of mammalian dental characters.
Nature 2004;432(7014):211-4.
2004: Wang Xiu-Ping; Suomalainen Marika; Jorgez Carolina J; Matzuk Martin M; Werner Sabine; Thesleff Irma
Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation.
Developmental cell 2004;7(5):719-30.
2004: Mustonen Tuija; Ilmonen Maritta; Pummila Marja; Kangas Aapo T; Laurikkala Johanna; Jaatinen Risto; Pispa Johanna; Gaide Olivier; Schneider Pascal; Thesleff Irma; Mikkola Marja L
Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages.
Development (Cambridge, England) 2004;131(20):4907-19.
2004: Pispa Johanna; Mustonen Tuija; Mikkola Marja L; Kangas Aapo T; Koppinen Petra; Lukinmaa Pirjo-Liisa; Jernvall Jukka; Thesleff Irma
Tooth patterning and enamel formation can be manipulated by misexpression of TNF receptor Edar.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;231(2):432-40.
2004: Yamashiro Takashi; Wang Xiu-Ping; Li Zhe; Oya Shinji; Aberg Thomas; Fukunaga Tomohiro; Kamioka Hiroshi; Speck Nancy A; Takano-Yamamoto Teruko; Thesleff Irma
Possible roles of Runx1 and Sox9 in incipient intramembranous ossification.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(10):1671-7.
2004: Wang Xiu-Ping; Suomalainen Marika; Jorgez Carolina J; Matzuk Martin M; Wankell Miriam; Werner Sabine; Thesleff Irma
Modulation of activin/bone morphogenetic protein signaling by follistatin is required for the morphogenesis of mouse molar teeth.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;231(1):98-108.
2004: James Martyn J; Järvinen Elina; Thesleff Irma
Bono1: a gene associated with regions of deposition of bone and dentine.
Gene expression patterns : GEP 2004;4(5):595-9.
2004: Rice Ritva; Spencer-Dene Bradley; Connor Elaine C; Gritli-Linde Amel; McMahon Andrew P; Dickson Clive; Thesleff Irma; Rice David P C
Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate.
The Journal of clinical investigation 2004;113(12):1692-700.
2004: Huysseune Ann; Thesleff Irma
Continuous tooth replacement: the possible involvement of epithelial stem cells.
BioEssays : news and reviews in molecular, cellular and developmental biology 2004;26(6):665-71.
2004: Aberg Thomas; Wang Xiu-Ping; Kim Jung-Hwan; Yamashiro Takashi; Bei Marianna; Rice Ritva; Ryoo Hyun-Mo; Thesleff Irma
Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis.
Developmental biology 2004;270(1):76-93.
2004: Lammi Laura; Arte Sirpa; Somer Mirja; Jarvinen Heikki; Lahermo Paivi; Thesleff Irma; Pirinen Sinikka; Nieminen Pekka
Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer.
American journal of human genetics 2004;74(5):1043-50.
2004: Partanen Anna Maija; Kiukkonen Anu; Sahlberg Carin; Alaluusua Satu; Thesleff Irma; Pohjanvirta Raimo; Lukinmaa Pirjo Liisa
Developmental toxicity of dioxin to mouse embryonic teeth in vitro: arrest of tooth morphogenesis involves stimulation of apoptotic program in the dental epithelium.
Toxicology and applied pharmacology 2004;194(1):24-33.
2004: Aberg Thomas; Cavender Adriana; Gaikwad Joel S; Bronckers Antonius L J J; Wang Xiuping; Waltimo-Sirén Janna; Thesleff Irma; D'Souza Rena N
Phenotypic changes in dentition of Runx2 homozygote-null mutant mice.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(1):131-9.
2003: Nieminen P; Kotilainen J; Aalto Y; Knuutila S; Pirinen S; Thesleff I
MSX1 gene is deleted in Wolf-Hirschhorn syndrome patients with oligodontia.
Journal of dental research 2003;82(12):1013-7.
2003: Laurikkala Johanna; Kassai Yoshiaki; Pakkasjärvi Leila; Thesleff Irma; Itoh Nobuyuki
Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot.
Developmental biology 2003;264(1):91-105.
2003: Lammi Laura; Halonen Katri; Pirinen Sinikka; Thesleff Irma; Arte Sirpa; Nieminen Pekka
A missense mutation in PAX9 in a family with distinct phenotype of oligodontia.
European journal of human genetics : EJHG 2003;11(11):866-71.
2003: Pispa Johanna; Thesleff Irma
Mechanisms of ectodermal organogenesis.
Developmental biology 2003;262(2):195-205.
2003: Rice Ritva; Rice David P C; Olsen Bjorn R; Thesleff Irma
Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4.
Developmental biology 2003;262(1):75-87.
2003: Pispa Johanna; Mikkola Marja L; Mustonen Tuija; Thesleff Irma
Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis.
Gene expression patterns : GEP 2003;3(5):675-9.
2003: Thesleff Irma
Developmental biology and building a tooth.
Quintessence international (Berlin, Germany : 1985) 2003;34(8):613-20.
2003: Rice D P C; Rice R; Thesleff I
Fgfr mRNA isoforms in craniofacial bone development.
Bone 2003;33(1):14-27.
2003: Mustonen Tuija; Pispa Johanna; Mikkola Marja L; Pummila Marja; Kangas Aapo T; Pakkasjärvi Leila; Jaatinen Risto; Thesleff Irma
Stimulation of ectodermal organ development by Ectodysplasin-A1.
Developmental biology 2003;259(1):123-36.
2003: Mikkola Marja L; Thesleff Irma
Ectodysplasin signaling in development.
Cytokine & growth factor reviews 2003;14(3-4):211-24.
2003: Kusu Naoki; Laurikkala Johanna; Imanishi Mayumi; Usui Hiroko; Konishi Morichika; Miyake Ayumi; Thesleff Irma; Itoh Nobuyuki
Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity.
The Journal of biological chemistry 2003;278(26):24113-7.
2003: Thesleff Irma
Epithelial-mesenchymal signalling regulating tooth morphogenesis.
Journal of cell science 2003;116(Pt 9):1647-8.
2003: Rice David P C; Rice Ritva; Thesleff Irma
Molecular mechanisms in calvarial bone and suture development, and their relation to craniosynostosis.
European journal of orthodontics 2003;25(2):139-48.
2003: Yamashiro T; Tummers M; Thesleff I
Expression of bone morphogenetic proteins and Msx genes during root formation.
Journal of dental research 2003;82(3):172-6.
2003: Tummers Mark; Thesleff Irma
Root or crown: a developmental choice orchestrated by the differential regulation of the epithelial stem cell niche in the tooth of two rodent species.
Development (Cambridge, England) 2003;130(6):1049-57.
2003: Thesleff Irma; Tummers Mark
Stem cells and tissue engineering: prospects for regenerating tissues in dental practice.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2003;12 Suppl 1():43-50.
2002: Yamashiro Takashi; Aberg Thomas; Levanon Ditsa; Groner Yoram; Thesleff Irma
Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development.
Mechanisms of development 2002;119 Suppl 1():S107-10.
2002: Yamashiro Takashi; Aberg Thomas; Levanon Ditsa; Groner Yoram; Thesleff Irma
Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development.
Gene expression patterns : GEP 2002;2(1-2):109-12.
2002: Mustonen Tuija; Tümmers Mark; Mikami Tadahisa; Itoh Nobuyuki; Zhang Niang; Gridley Thomas; Thesleff Irma
Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.
Developmental biology 2002;248(2):281-93.
2002: Thesleff Irma; Mikkola Marja L
Death receptor signaling giving life to ectodermal organs.
Science's STKE : signal transduction knowledge environment 2002;2002(131):pe22.
2002: Laurikkala Johanna; Pispa Johanna; Jung Han-Sung; Nieminen Pekka; Mikkola Marja; Wang Xiuping; Saarialho-Kere Ulpu; Galceran Juan; Grosschedl Rudolf; Thesleff Irma
Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar.
Development (Cambridge, England) 2002;129(10):2541-53.
2002: Vartiainen Maria K; Mustonen Tuija; Mattila Pieta K; Ojala Pauli J; Thesleff Irma; Partanen Juha; Lappalainen Pekka
The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics.
Molecular biology of the cell 2002;13(1):183-94.
2002: Thesleff Irma; Mikkola Marja
The role of growth factors in tooth development.
International review of cytology 2002;217():93-135.
2002: Sahlberg Carin; Mustonen Tuija; Thesleff Irma
Explant cultures of embryonic epithelium. Analysis of mesenchymal signals.
Methods in molecular biology (Clifton, N.J.) 2002;188():373-82.
2001: Nieminen P; Arte S; Tanner D; Paulin L; Alaluusua S; Thesleff I; Pirinen S
Identification of a nonsense mutation in the PAX9 gene in molar oligodontia.
European journal of human genetics : EJHG 2001;9(10):743-6.
2001: Koppinen P; Pispa J; Laurikkala J; Thesleff I; Mikkola M L
Signaling and subcellular localization of the TNF receptor Edar.
Experimental cell research 2001;269(2):180-92.
2001: Thesleff I; Keränen S; Jernvall J
Enamel knots as signaling centers linking tooth morphogenesis and odontoblast differentiation.
Advances in dental research 2001;15():14-8.
2001: Pirinen S; Kentala A; Nieminen P; Varilo T; Thesleff I; Arte S
Recessively inherited lower incisor hypodontia.
Journal of medical genetics 2001;38(8):551-6.
2001: Arte S; Nieminen P; Apajalahti S; Haavikko K; Thesleff I; Pirinen S
Characteristics of incisor-premolar hypodontia in families.
Journal of dental research 2001;80(5):1445-50.
2001: Sahlberg C; Aukhil I; Thesleff I
Tenascin-C in developing mouse teeth: expression of splice variants and stimulation by TGFbeta and FGF.
European journal of oral sciences 2001;109(2):114-24.
2001: Laurikkala J; Mikkola M; Mustonen T; Aberg T; Koppinen P; Pispa J; Nieminen P; Galceran J; Grosschedl R; Thesleff I
TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis.
Developmental biology 2001;229(2):443-55.
2000: Jernvall J; Keränen S V; Thesleff I
Evolutionary modification of development in mammalian teeth: quantifying gene expression patterns and topography.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14444-8.
2000: Kettunen P; Laurikkala J; Itäranta P; Vainio S; Itoh N; Thesleff I
Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 2000;219(3):322-32.
2000: Thesleff I
Genetic basis of tooth development and dental defects.
Acta odontologica Scandinavica 2000;58(5):191-4.
2000: Pirvola U; Spencer-Dene B; Xing-Qun L; Kettunen P; Thesleff I; Fritzsch B; Dickson C; Ylikoski J
FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(16):6125-34.
2000: Rice D P; Aberg T; Chan Y; Tang Z; Kettunen P J; Pakarinen L; Maxson R E; Thesleff I
Integration of FGF and TWIST in calvarial bone and suture development.
Development (Cambridge, England) 2000;127(9):1845-55.
2000: Jernvall J; Thesleff I
Reiterative signaling and patterning during mammalian tooth morphogenesis.
Mechanisms of development 2000;92(1):19-29.
1999: Pispa J; Jung H S; Jernvall J; Kettunen P; Mustonen T; Tabata M J; Kere J; Thesleff I
Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF.
Developmental biology 1999;216(2):521-34.
1999: Mikkola M L; Pispa J; Pekkanen M; Paulin L; Nieminen P; Kere J; Thesleff I
Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion.
Mechanisms of development 1999;88(2):133-46.
1999: Harada H; Kettunen P; Jung H S; Mustonen T; Wang Y A; Thesleff I
Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling.
The Journal of cell biology 1999;147(1):105-20.
1999: Ohshima H; Wartiovaara J; Thesleff I
Developmental regulation and ultrastructure of glycogen deposits during murine tooth morphogenesis.
Cell and tissue research 1999;297(2):271-81.
1999: Rice D P; Kim H J; Thesleff I
Apoptosis in murine calvarial bone and suture development.
European journal of oral sciences 1999;107(4):265-75.
1999: Keränen S V; Kettunen P; Aberg T; Thesleff I; Jernvall J
Gene expression patterns associated with suppression of odontogenesis in mouse and vole diastema regions.
Development genes and evolution 1999;209(8):495-506.
1999: Thesleff I; Aberg T
Molecular regulation of tooth development.
Bone 1999;25(1):123-5.
1999: D'Souza R N; Aberg T; Gaikwad J; Cavender A; Owen M; Karsenty G; Thesleff I
Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice.
Development (Cambridge, England) 1999;126(13):2911-20.
1999: Sahlberg C; Reponen P; Tryggvason K; Thesleff I
Timp-1, -2 and -3 show coexpression with gelatinases A and B during mouse tooth morphogenesis.
European journal of oral sciences 1999;107(2):121-30.
1999: Jung H S; Oropeza V; Thesleff I
Shh, Bmp-2, Bmp-4 and Fgf-8 are associated with initiation and patterning of mouse tongue papillae.
Mechanisms of development 1999;81(1-2):179-82.
1999: Thesleff I; Sahlberg C
Organ culture in the analysis of tissue interactions.
Methods in molecular biology (Clifton, N.J.) 1999;97():23-31.
1998: Thesleff I
The genetic basis of normal and abnormal craniofacial development.
Acta odontologica Scandinavica 1998;56(6):321-5.
1998: Partanen A M; Alaluusua S; Miettinen P J; Thesleff I; Tuomisto J; Pohjanvirta R; Lukinmaa P L
Epidermal growth factor receptor as a mediator of developmental toxicity of dioxin in mouse embryonic teeth.
Laboratory investigation; a journal of technical methods and pathology 1998;78(12):1473-81.
1998: Keränen S V; Aberg T; Kettunen P; Thesleff I; Jernvall J
Association of developmental regulatory genes with the development of different molar tooth shapes in two species of rodents.
Development genes and evolution 1998;208(9):477-86.
1998: Luukko K; Saarma M; Thesleff I
Neurturin mRNA expression suggests roles in trigeminal innervation of the first branchial arch and in tooth formation.
Developmental dynamics : an official publication of the American Association of Anatomists 1998;213(2):207-19.
1998: Bayés M; Hartung A J; Ezer S; Pispa J; Thesleff I; Srivastava A K; Kere J
The anhidrotic ectodermal dysplasia gene (EDA) undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats.
Human molecular genetics 1998;7(11):1661-9.
1998: Montonen O; Ezer S; Laurikkala J; Karjalainen-Lindsberg M L; Thesleff I; Kere J; Saarialho-Kere U
Expression of the anhidrotic ectodermal dysplasia gene is reduced in skin cancer coinciding with reduced E-cadherin.
Experimental dermatology 1998;7(4):168-74.
1998: Sahlberg C; Hormia M; Airenne T; Thesleff I
Laminin gamma2 expression is developmentally regulated during murine tooth morphogenesis and is intense in ameloblasts.
Journal of dental research 1998;77(8):1589-96.
1998: Hormia M; Sahlberg C; Thesleff I; Airenne T
The epithelium-tooth interface--a basal lamina rich in laminin-5 and lacking other known laminin isoforms.
Journal of dental research 1998;77(7):1479-85.
1998: Kim H J; Rice D P; Kettunen P J; Thesleff I
FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development.
Development (Cambridge, England) 1998;125(7):1241-51.
1998: Kettunen P; Thesleff I
Expression and function of FGFs-4, -8, and -9 suggest functional redundancy and repetitive use as epithelial signals during tooth morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 1998;211(3):256-68.
1998: Montonen O; Ezer S; Saarialho-Kere U K; Herva R; Karjalainen-Lindsberg M L; Kaitila I; Schlessinger D; Srivastava A K; Thesleff I; Kere J
The gene defective in anhidrotic ectodermal dysplasia is expressed in the developing epithelium, neuroectoderm, thymus, and bone.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(3):281-9.
1998: Nieminen P; Pekkanen M; Aberg T; Thesleff I
A graphical WWW-database on gene expression in tooth.
European journal of oral sciences 1998;106 Suppl 1():7-11.
1998: Jernvall J; Aberg T; Kettunen P; Keränen S; Thesleff I
The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot.
Development (Cambridge, England) 1998;125(2):161-9.
1998: Kettunen P; Karavanova I; Thesleff I
Responsiveness of developing dental tissues to fibroblast growth factors: expression of splicing alternatives of FGFR1, -2, -3, and of FGFR4; and stimulation of cell proliferation by FGF-2, -4, -8, and -9.
Developmental genetics 1998;22(4):374-85.
1997: Rice D P; Kim H J; Thesleff I
Detection of gelatinase B expression reveals osteoclastic bone resorption as a feature of early calvarial bone development.
Bone 1997;21(6):479-86.
1997: Luukko K; Suvanto P; Saarma M; Thesleff I
Expression of GDNF and its receptors in developing tooth is developmentally regulated and suggests multiple roles in innervation and organogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 1997;210(4):463-71.
1997: Aberg T; Wozney J; Thesleff I
Expression patterns of bone morphogenetic proteins (Bmps) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation.
Developmental dynamics : an official publication of the American Association of Anatomists 1997;210(4):383-96.
1997: Srivastava A K; Pispa J; Hartung A J; Du Y; Ezer S; Jenks T; Shimada T; Pekkanen M; Mikkola M L; Ko M S; Thesleff I; Kere J; Schlessinger D
The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13069-74.
1997: Thesleff I; Sharpe P
Signalling networks regulating dental development.
Mechanisms of development 1997;67(2):111-23.
1997: Luukko K; Arumäe U; Karavanov A; Moshnyakov M; Sainio K; Sariola H; Saarma M; Thesleff I
Neurotrophin mRNA expression in the developing tooth suggests multiple roles in innervation and organogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 1997;210(2):117-29.
1997: Luukko K; Sainio K; Sariola H; Saarma M; Thesleff I
Localization of nerve cells in the developing rat tooth.
Journal of dental research 1997;76(7):1350-6.
1997: Thesleff I; Jernvall J
The enamel knot: a putative signaling center regulating tooth development.
Cold Spring Harbor symposia on quantitative biology 1997;62():257-67.
1997: Thesleff I; Aberg T
Tooth morphogenesis and the differentiation of ameloblasts.
Ciba Foundation symposium 1997;205():3-12; discussion 12-7.
1996: Thesleff I; Nieminen P
Tooth morphogenesis and cell differentiation.
Current opinion in cell biology 1996;8(6):844-50.
1996: Arte S; Nieminen P; Pirinen S; Thesleff I; Peltonen L
Gene defect in hypodontia: exclusion of EGF, EGFR, and FGF-3 as candidate genes.
Journal of dental research 1996;75(6):1346-52.
1996: Thesleff I; Vaahtokari A; Vainio S; Jowett A
Molecular mechanisms of cell and tissue interactions during early tooth development.
The Anatomical record 1996;245(2):151-61.
1996: Luukko K; Moshnyakov M; Sainio K; Saarma M; Sariola H; Thesleff I
Expression of neurotrophin receptors during rat tooth development is developmentally regulated, independent of innervation, and suggests functions in the regulation of morphogenesis and innervation.
Developmental dynamics : an official publication of the American Association of Anatomists 1996;206(1):87-99.
1996: Vaahtokari A; Aberg T; Jernvall J; Keränen S; Thesleff I
The enamel knot as a signaling center in the developing mouse tooth.
Mechanisms of development 1996;54(1):39-43.
1996: Vaahtokari A; Aberg T; Thesleff I
Apoptosis in the developing tooth: association with an embryonic signaling center and suppression by EGF and FGF-4.
Development (Cambridge, England) 1996;122(1):121-9.
1996: Mitsiadis T A; Thesleff I; Lendahl U
Mouse Serrate-1 and Notch genes differ in their response to signaling molecules during odontogenesis.
The International journal of developmental biology 1996;Suppl 1():113S-114S.
1995: Thesleff I
Tooth morphogenesis.
Advances in dental research 1995;9(3 Suppl):12.
1995: Lukinmaa P L; Jensen B L; Thesleff I; Andreasen J O; Kreiborg S
Histological observations of teeth and peridental tissues in cleidocranial dysplasia imply increased activity of odontogenic epithelium and abnormal bone remodeling.
Journal of craniofacial genetics and developmental biology 1995;15(4):212-21.
1995: Nieminen P; Arte S; Pirinen S; Peltonen L; Thesleff I
Gene defect in hypodontia: exclusion of MSX1 and MSX2 as candidate genes.
Human genetics 1995;96(3):305-8.
1995: Mitsiadis T A; Lardelli M; Lendahl U; Thesleff I
Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate.
The Journal of cell biology 1995;130(2):407-18.
1995: Thesleff I
Homeobox genes and growth factors in regulation of craniofacial and tooth morphogenesis.
Acta odontologica Scandinavica 1995;53(3):129-34.
1995: Mitsiadis T A; Muramatsu T; Muramatsu H; Thesleff I
Midkine (MK), a heparin-binding growth/differentiation factor, is regulated by retinoic acid and epithelial-mesenchymal interactions in the developing mouse tooth, and affects cell proliferation and morphogenesis.
The Journal of cell biology 1995;129(1):267-81.
1995: Reponen P; Leivo I; Sahlberg C; Apte S S; Olsen B R; Thesleff I; Tryggvason K
92-kDa type IV collagenase and TIMP-3, but not 72-kDa type IV collagenase or TIMP-1 or TIMP-2, are highly expressed during mouse embryo implantation.
Developmental dynamics : an official publication of the American Association of Anatomists 1995;202(4):388-96.
1995: Elomaa O; Kangas M; Sahlberg C; Tuukkanen J; Sormunen R; Liakka A; Thesleff I; Kraal G; Tryggvason K
Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages.
Cell 1995;80(4):603-9.
1995: Thesleff I; Vaahtokari A; Partanen A M
Regulation of organogenesis. Common molecular mechanisms regulating the development of teeth and other organs.
The International journal of developmental biology 1995;39(1):35-50.
1995: Mitsiadis T A; Salmivirta M; Muramatsu T; Muramatsu H; Rauvala H; Lehtonen E; Jalkanen M; Thesleff I
Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis.
Development (Cambridge, England) 1995;121(1):37-51.
1995: Thesleff I; Vaahtokari A; Kettunen P; Aberg T
Epithelial-mesenchymal signaling during tooth development.
Connective tissue research 1995;32(1-4):9-15.
1994: Reponen P; Sahlberg C; Munaut C; Thesleff I; Tryggvason K
High expression of 92-kDa type IV collagenase (gelatinase) in the osteoclast lineage during mouse development.
Annals of the New York Academy of Sciences 1994;732():472-5.
1994: Jernvall J; Kettunen P; Karavanova I; Martin L B; Thesleff I
Evidence for the role of the enamel knot as a control center in mammalian tooth cusp formation: non-dividing cells express growth stimulating Fgf-4 gene.
The International journal of developmental biology 1994;38(3):463-9.
1994: Reponen P; Sahlberg C; Munaut C; Thesleff I; Tryggvason K
High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development.
The Journal of cell biology 1994;124(6):1091-1102.
1993: Lukinmaa P L; Vaahtokari A; Vainio S; Sandberg M; Waltimo J; Thesleff I
Transient expression of type III collagen by odontoblasts: developmental changes in the distribution of pro-alpha 1(III) and pro-alpha 1(I) collagen mRNAs in dental tissues.
Matrix (Stuttgart, Germany) 1993;13(6):503-15.
1993: Nieminen P; Vainio S; Jernvall J; Lukinmaa P L; Lehtonen E; Thesleff I
A chondroitin sulfate epitope in mammalian dental pulp and its developmental expression in mouse dental papilla.
Journal of dental research 1993;72(11):1460-72.
1993: Vainio S; Karavanova I; Jowett A; Thesleff I
Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development.
Cell 1993;75(1):45-58.
1993: Hormia M; Thesleff I; Perheentupa J; Pesonen K; Saxén L
Increased rate of salivary epidermal growth factor secretion in patients with juvenile periodontitis.
Scandinavian journal of dental research 1993;101(3):138-44.
1993: Jowett A K; Vainio S; Ferguson M W; Sharpe P T; Thesleff I
Epithelial-mesenchymal interactions are required for msx 1 and msx 2 gene expression in the developing murine molar tooth.
Development (Cambridge, England) 1993;117(2):461-70.
1993: Vinkka-Puhakka H; Thesleff I
Initiation of secondary cartilage in the mandible of the Syrian hamster in the absence of muscle function.
Archives of oral biology 1993;38(1):49-54.
1992: Sahlberg C; Reponen P; Tryggvason K; Thesleff I
Association between the expression of murine 72 kDa type IV collagenase by odontoblasts and basement membrane degradation during mouse tooth development.
Archives of oral biology 1992;37(12):1021-30.
1992: Karavanova I; Vainio S; Thesleff I
Transient and recurrent expression of the Egr-1 gene in epithelial and mesenchymal cells during tooth morphogenesis suggests involvement in tissue interactions and in determination of cell fate.
Mechanisms of development 1992;39(1-2):41-50.
1992: Könönen M; Hormia M; Kivilahti J; Hautaniemi J; Thesleff I
Effect of surface processing on the attachment, orientation, and proliferation of human gingival fibroblasts on titanium.
Journal of biomedical materials research 1992;26(10):1325-41.
1992: Vainio S; Thesleff I
Coordinated induction of cell proliferation and syndecan expression in dental mesenchyme by epithelium: evidence for diffusible signals.
Developmental dynamics : an official publication of the American Association of Anatomists 1992;194(2):105-17.
1992: Vainio S; Thesleff I
Sequential induction of syndecan, tenascin and cell proliferation associated with mesenchymal cell condensation during early tooth development.
Differentiation; research in biological diversity 1992;50(2):97-105.
1992: Reponen P; Sahlberg C; Huhtala P; Hurskainen T; Thesleff I; Tryggvason K
Molecular cloning of murine 72-kDa type IV collagenase and its expression during mouse development.
The Journal of biological chemistry 1992;267(11):7856-62.
1992: Lukinmaa P L; Vaahtokari A; Vainio S; Thesleff I
Expression of type I collagen pro-alpha 2 chain mRNA in adult human permanent teeth as revealed by in situ hybridization.
Journal of dental research 1992;71(1):36-42.
1992: Saxén L; Thesleff I
Epithelial-mesenchymal interactions in murine organogenesis.
Ciba Foundation symposium 1992;165():183-93; discussion 193-8.
1992: Thesleff I; Vaahtokari A
The role of growth factors in determination and differentiation of the odontoblastic cell lineage.
Proceedings of the Finnish Dental Society. Suomen Hammaslääkäriseuran toimituksia 1992;88 Suppl 1():357-68.
1992: Thesleff I
Craniofacial developmental biology--an expanding field of dental research.
Proceedings of the Finnish Dental Society. Suomen Hammaslääkäriseuran toimituksia 1992;88(3-4):163-8.
1991: Thesleff I
Tooth development.
Dental update 1991;18(9):382-4, 386-7.
1991: Vaahtokari A; Vainio S; Thesleff I
Associations between transforming growth factor beta 1 RNA expression and epithelial-mesenchymal interactions during tooth morphogenesis.
Development (Cambridge, England) 1991;113(3):985-94.
1991: Thesleff I; Partanen A M; Vainio S
Epithelial-mesenchymal interactions in tooth morphogenesis: the roles of extracellular matrix, growth factors, and cell surface receptors.
Journal of craniofacial genetics and developmental biology 1991;11(4):229-37.
1991: Vainio S; Jalkanen M; Vaahtokari A; Sahlberg C; Mali M; Bernfield M; Thesleff I
Expression of syndecan gene is induced early, is transient, and correlates with changes in mesenchymal cell proliferation during tooth organogenesis.
Developmental biology 1991;147(2):322-33.
1991: Sariola H; Saarma M; Sainio K; Arumäe U; Palgi J; Vaahtokari A; Thesleff I; Karavanov A
Dependence of kidney morphogenesis on the expression of nerve growth factor receptor.
Science (New York, N.Y.) 1991;254(5031):571-3.
1991: Elenius K; Vainio S; Laato M; Salmivirta M; Thesleff I; Jalkanen M
Induced expression of syndecan in healing wounds.
The Journal of cell biology 1991;114(3):585-95.
1991: Nordlund L; Hormia M; Saxén L; Thesleff I
Immunohistochemical localization of epidermal growth factor receptors in human gingival epithelia.
Journal of periodontal research 1991;26(4):333-8.
1991: Salmivirta M; Elenius K; Vainio S; Hofer U; Chiquet-Ehrismann R; Thesleff I; Jalkanen M
Syndecan from embryonic tooth mesenchyme binds tenascin.
The Journal of biological chemistry 1991;266(12):7733-9.
1991: Lukinmaa P L; Mackie E J; Thesleff I
Immunohistochemical localization of the matrix glycoproteins--tenascin and the ED-sequence-containing form of cellular fibronectin--in human permanent teeth and periodontal ligament.
Journal of dental research 1991;70(1):19-26.
1991: Thesleff I; Vaahtokari A; Vainio S
Advances in histological methods open up new perspectives for craniofacial growth research.
Proceedings of the Finnish Dental Society. Suomen Hammaslääkäriseuran toimituksia 1991;87(1):23-32.
1990: Thesleff I; Vainio S; Salmivirta M; Jalkanen M
Syndecan and tenascin: induction during early tooth morphogenesis and possible interactions.
Cell differentiation and development : the official journal of the International Society of Developmental Biologists 1990;32(3):383-9.
1990: Thesleff I; Vaahtokari A; Vainio S
Molecular changes during determination and differentiation of the dental mesenchymal cell lineage.
Journal de biologie buccale 1990;18(3):179-88.
1990: Väkevä L; Mackie E; Kantomaa T; Thesleff I
Comparison of the distribution patterns of tenascin and alkaline phosphatase in developing teeth, cartilage, and bone of rats and mice.
The Anatomical record 1990;228(1):69-76.
1989: Vainio S; Jalkanen M; Thesleff I
Syndecan and tenascin expression is induced by epithelial-mesenchymal interactions in embryonic tooth mesenchyme.
The Journal of cell biology 1989;108(5):1945-53.
1989: Thesleff I; Vainio S; Jalkanen M
Cell-matrix interactions in tooth development.
The International journal of developmental biology 1989;33(1):91-7.
1989: Partanen A M; Thesleff I
Growth factors and tooth development.
The International journal of developmental biology 1989;33(1):165-72.
1988: Thesleff I; Jalkanen M; Vainio S; Bernfield M
Cell surface proteoglycan expression correlates with epithelial-mesenchymal interaction during tooth morphogenesis.
Developmental biology 1988;129(2):565-72.
1988: Vainio S; Lehtonen E; Kaartinen M; Thesleff I
Production of monoclonal antibodies against murine dental papilla.
Scandinavian journal of dental research 1988;96(3):177-87.
1988: Thesleff I; Viinikka L; Saxén L; Lehtonen E; Perheentupa J
The parotid gland is the main source of human salivary epidermal growth factor.
Life sciences 1988;43(1):13-8.
1988: Thesleff I; Kantomaa T; Mackie E; Chiquet-Ehrismann R
Immunohistochemical localization of the matrix glycoprotein tenascin in the skull of the growing rat.
Archives of oral biology 1988;33(6):383-90.
1987: Thesleff I; Mackie E; Vainio S; Chiquet-Ehrismann R
Changes in the distribution of tenascin during tooth development.
Development (Cambridge, England) 1987;101(2):289-96.
1987: Thesleff I
Does epidermal growth factor control tooth eruption?
ASDC journal of dentistry for children 1987;54(5):321-9.
1987: Rihtniemi L; Thesleff I
An autoradiographic study on the effect of epidermal growth factor on cell proliferation in erupting mouse incisors.
Archives of oral biology 1987;32(12):859-63.

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