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Steffen Thiel

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Christel R Brinkmann; Steffen Thiel; Daniel E Otzen
Protein-fatty acid complexes: biochemistry, biophysics and function.
Søren E Degn; Steffen Thiel; Jens C Jensenius
Recombinant expression of the autocatalytic complement protease MASP-1 is crucially dependent on co-expression with its inhibitor, C1 inhibitor.
Troels R Kjaer; Grith L Sørensen; Uffe B Skov Sørensen; Annette G Hansen; Anne T Holm; Jens C Jensenius; Steffen Thiel
M-ficolin binds selectively to the capsular polysaccharides of Streptococcus pneumoniae serotypes 19B and 19C and of a Streptococcus mitis strain.

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2013: Christel R Brinkmann; Steffen Thiel; Daniel E Otzen
Protein-fatty acid complexes: biochemistry, biophysics and function.
The FEBS journal 2013;280(8):1733-49.
2013: Søren E Degn; Steffen Thiel; Jens C Jensenius
Recombinant expression of the autocatalytic complement protease MASP-1 is crucially dependent on co-expression with its inhibitor, C1 inhibitor.
Protein expression and purification 2013;88(2):173-82.
2013: Troels R Kjaer; Grith L Sørensen; Uffe B Skov Sørensen; Annette G Hansen; Anne T Holm; Jens C Jensenius; Steffen Thiel
M-ficolin binds selectively to the capsular polysaccharides of Streptococcus pneumoniae serotypes 19B and 19C and of a Streptococcus mitis strain.
Infection and immunity 2013;81(2):452-9.
2012: Søren E Degn; Duygu Duman; Annette G Hansen; Lisbeth Jensen; Jens C Jensenius; Mustafa Tekin; Steffen Thiel
Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(8):3957-69.
2012: Rune T Kidmose; Troels R Kjaer; Nick S Laursen; Sofia Sirotkina; Lars Sottrup-Jensen; Steffen Thiel; Laure Yatime; József Dobó; Péter Gál; Gregers R Andersen
Structural basis for activation of the complement system by component C4 cleavage.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(38):15425-30.
2012: Thor Petersen; Steffen Thiel; Svend Ellermann-Eriksen; Anné Møller-Larsen; Tove Christensen
Effects of interferon-beta therapy on elements in the antiviral immune response towards the human herpesviruses EBV, HSV, and VZV, and to the human endogenous retroviruses HERV-H and HERV-W in multiple sclerosis.
Journal of neuroimmunology 2012;249(1-2):105-8.
2012: Steffen Thiel; H J Nielsen; S E Degn; József Dobó; Péter Gál; L Jensen; Jens C Jensenius
Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components.
Clinical and experimental immunology 2012;169(1):38-48.
2012: C G Ammitzboll; Bent Deleuran; Torkell Ellingsen; Jens C Jensenius; Anette Jorgensen; Steffen Thiel; Kristian Stengaard-Pedersen
Levels of lectin pathway proteins in plasma and synovial fluid of rheumatoid arthritis and osteoarthritis.
Rheumatology international 2012;32(5):1457-63.
2012: Rikke M Zacho; Lisbeth Jensen; Jens C Jensenius; Randi Terp; Steffen Thiel
Studies of the pattern recognition molecule H-ficolin: specificity and purification.
The Journal of biological chemistry 2012;287(11):8071-81.
2012: Louise C Gjelstrup; Jørn D Kaspersen; Peter Kingshott; Cristiano L P Oliveira; Jan S Pedersen; Steffen Thiel; Nicole M Thielens; Manja A Behrens; Thomas Vorup-Jensen
The role of nanometer-scaled ligand patterns in polyvalent binding by large mannan-binding lectin oligomers.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(3):1292-306.
2012: P H Høyem; S B Pedersen; B Richelsen; Steffen Thiel; J M Bruun; Jens Sandahl Christiansen; Troels Krarup Hansen
The effect of weight loss on serum mannose-binding lectin levels.
Clinical & developmental immunology 2012;2012():354894.
2012: Christian Gytz Ammitzbøll; Martin Bøgsted; Troels Rønn Kjær; Hans Jørgen Nielsen; Rudi Steffensen; Kristian Stengaard-Pedersen; Steffen Thiel; Jens Christian Jensenius
Non-synonymous polymorphisms in the FCN1 gene determine ligand-binding ability and serum levels of M-ficolin.
PloS one 2012;7(11):e50585.
2011: Søren E Degn; Annette G Hansen; Ole Nielsen; R Steffensen; Steffen Thiel; Jens C Jensenius
MAp19, the alternative splice product of the MASP2 gene.
Journal of immunological methods 2011;373(1-2):89-101.
2011: Jens Magnus Bernth-Jensen; Jens Christian Jensenius; Bjarne Møller; Steffen Thiel
Biological variation of anti-αGal-antibodies studied by a novel Time-Resolved ImmunoFluorometric Assay.
Journal of immunological methods 2011;373(1-2):26-35.
2011: Louise Carstensen Gjelstrup; Steen V Petersen; Stig Henrik Andersen; Anna M Blom; Jan J Enghild; Thomas Vorup-Jensen; Steffen Thiel
The role of higher-order protein structure in supporting binding by heteroclitic monoclonal antibodies: the monoclonal antibody KIM185 to CD18 also binds C4-binding protein.
Molecular immunology 2011;49(1-2):38-47.
2011: Troels R Kjaer; Ole Nielsen; Uffe B S Sørensen; Steffen Thiel; Annette G Hansen; Jens C Jensenius
Investigations on the pattern recognition molecule M-ficolin: quantitative aspects of bacterial binding and leukocyte association.
Journal of leukocyte biology 2011;90(3):425-37.
2011: Therese Ovesen; Steffen Thiel; Jens Magnus Jensen; Jonas Rickers Kragelund; Jens Erik Veirum
Immunodeficiencies in children with chronic post tympanic otorrhoea.
Danish medical bulletin 2011;58(7):A4282.
2011: Søren E Degn; Jens C Jensenius; Steffen Thiel
Disease-causing mutations in genes of the complement system.
American journal of human genetics 2011;88(6):689-705.
2011: Christel Rothe Brinkmann; Christian W Heegaard; Torben Ellebaek Petersen; Jens Christian Jensenius; Steffen Thiel
The toxicity of bovine α-lactalbumin made lethal to tumor cells is highly dependent on oleic acid and induces killing in cancer cell lines and noncancer-derived primary cells.
The FEBS journal 2011;278(11):1955-67.
2011: Seraina Sallenbach; Steffen Thiel; Christoph Aebi; Margrith Otth; Susanna Bigler; Jens C Jensenius; Luregn J Schlapbach; Roland A Ammann
Serum concentrations of lectin-pathway components in healthy neonates, children and adults: mannan-binding lectin (MBL), M-, L-, and H-ficolin, and MBL-associated serine protease-2 (MASP-2).
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2011;22(4):424-30.
2011: C R Brinkmann; Steffen Thiel; Morten K Larsen; Torben E Petersen; Jens C Jensenius; Christian W Heegaard
Preparation and comparison of cytotoxic complexes formed between oleic acid and either bovine or human α-lactalbumin.
Journal of dairy science 2011;94(5):2159-70.
2010: Søren E Degn; Lisbeth Jensen; Péter Gál; József Dobó; Steffen H Holmvad; Jens C Jensenius; Steffen Thiel
Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system.
Journal of immunological methods 2010;361(1-2):37-50.
2010: Luregn J Schlapbach; Maika Mattmann; Steffen Thiel; Colette Boillat; Margrith Otth; Mathias Nelle; Bendicht Wagner; Jens C Jensenius; Christoph Aebi
Differential role of the lectin pathway of complement activation in susceptibility to neonatal sepsis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010;51(2):153-62.
2010: Thomas Wittenborn; Steffen Thiel; Lisbeth Jensen; Hans J Nielsen; Jens C Jensenius
Characteristics and biological variations of M-ficolin, a pattern recognition molecule, in plasma.
Journal of innate immunity 2010;2(2):167-80.
2009: Thor Petersen; Anné Møller-Larsen; Steffen Thiel; Tomasz Brudek; Troels Krarup Hansen; Tove Christensen
Effects of interferon-beta therapy on innate and adaptive immune responses to the human endogenous retroviruses HERV-H and HERV-W, cytokine production, and the lectin complement activation pathway in multiple sclerosis.
Journal of neuroimmunology 2009;215(1-2):108-16.
2009: Marieta M Ruseva; Martin Kolev; Frederik Dagnaes-Hansen; Soren B Hansen; Kazue Takahashi; AB Ezekowitz; Steffen Thiel; Jens C Jensenius; Mihaela Gadjeva
Mannan-binding lectin deficiency modulates the humoral immune response dependent on the genetic environment.
Immunology 2009;127(2):279-88.
2009: Steffen Thiel; Martin Kolev; Søren Degn; R Steffensen; Annette G Hansen; Marieta M Ruseva; Jens C Jensenius
Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):2939-47.
2009: Steffen Thiel; Mihaela Gadjeva
Humoral pattern recognition molecules: mannan-binding lectin and ficolins.
Advances in experimental medicine and biology 2009;653():58-73.
2007: Steffen Thiel
Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins.
Molecular immunology 2007;44(16):3875-88.
2007: Mette Møller-Kristensen; Michael Hamblin; Steffen Thiel; Jens C Jensenius; Kazue Takahashi
Burn injury reveals altered phenotype in mannan-binding lectin-deficient mice.
The Journal of investigative dermatology 2007;127(6):1524-31.
2007: Florence Teillet; Monique Lacroix; Steffen Thiel; Dietmar Weilguny; Teit Agger; Gérard J Arlaud; Nicole M Thielens
Identification of the site of human mannan-binding lectin involved in the interaction with its partner serine proteases: the essential role of Lys55.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5710-6.
2007: Dong Mingdong; Sailong Xu; Cristiano L P Oliveira; Jan Skov Pedersen; Steffen Thiel; Flemming Besenbacher; Thomas Vorup-Jensen
Conformational changes in mannan-binding lectin bound to ligand surfaces.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):3016-22.
2007: Steffen Thiel; R Steffensen; I J Christensen; W K Ip; Y L Lau; I J M Reason; Hans Eiberg; Mihaela Gadjeva; Marieta M Ruseva; Jens C Jensenius
Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms.
Genes and immunity 2007;8(2):154-63.
2007: Mette Møller-Kristensen; Steffen Thiel; Anders Sjöholm; Misao Matsushita; Jens C Jensenius
Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway.
International immunology 2007;19(2):141-9.
2007: Tove Christensen; Thor Petersen; Steffen Thiel; Tomasz Brudek; Svend Ellermann-Eriksen; Anné Møller-Larsen
Gene-environment interactions in multiple sclerosis: innate and adaptive immune responses to human endogenous retrovirus and herpesvirus antigens and the lectin complement activation pathway.
Journal of neuroimmunology 2007;183(1-2):175-88.
2007: Simon Glerup; Søren Kløverpris; Lisbeth S Laursen; Frederik Dagnaes-Hansen; Steffen Thiel; Cheryl A Conover; Claus Oxvig
Cell surface detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor.
The Journal of biological chemistry 2007;282(3):1769-78.
2007: Søren E Degn; Steffen Thiel; Jens C Jensenius
New perspectives on mannan-binding lectin-mediated complement activation.
Immunobiology 2007;212(4-5):301-11.
2006: Ming Zhang; Kazue Takahashi; Elisabeth M Alicot; Thomas Vorup-Jensen; Benedikt Kessler; Steffen Thiel; Jens C Jensenius; R Alan B Ezekowitz; Francis D Moore; Michael C Carroll
Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4727-34.
2006: Pernille D Frederiksen; Steffen Thiel; Lisbeth Jensen; Annette G Hansen; Finn Matthiesen; Jens C Jensenius
Quantification of mannan-binding lectin.
Journal of immunological methods 2006;315(1-2):49-60.
2006: C M Sørensen; Troels Krarup Hansen; R Steffensen; Jens C Jensenius; Steffen Thiel
Hormonal regulation of mannan-binding lectin synthesis in hepatocytes.
Clinical and experimental immunology 2006;145(1):173-82.
2006: Mette Møller-Kristensen; W K Eddie Ip; Lei Shi; Lakshmi D Gowda; Michael Hamblin; Steffen Thiel; Jens C Jensenius; R Alan B Ezekowitz; Kazue Takahashi
Deficiency of mannose-binding lectin greatly increases susceptibility to postburn infection with Pseudomonas aeruginosa.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1769-75.
2006: Steffen Thiel; Pernille D Frederiksen; Jens C Jensenius
Clinical manifestations of mannan-binding lectin deficiency.
Molecular immunology 2006;43(1-2):86-96.
2005: Pernille D Frederiksen; Steffen Thiel; C B Larsen; Jens C Jensenius
M-ficolin, an innate immune defence molecule, binds patterns of acetyl groups and activates complement.
Scandinavian journal of immunology 2005;62(5):462-73.
2005: Anne Lene Dalkjaer Riis; Troels Krarup Hansen; Steffen Thiel; Claus Gravholt; Signe Gjedde; Lars C Gormsen; Jens Otto Lunde Jørgensen; Jørgen Weeke; Niels Møller
Thyroid hormone increases mannan-binding lectin levels.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(5):643-9.
2005: Rikke Sørensen; Steffen Thiel; Jens C Jensenius
Mannan-binding-lectin-associated serine proteases, characteristics and disease associations.
Springer seminars in immunopathology 2005;27(3):299-319.
2005: Mette Møller-Kristensen; W Wang; Marieta M Ruseva; Steffen Thiel; S Nielsen; Kazue Takahashi; Lei Shi; AB Ezekowitz; Jens C Jensenius; Mihaela Gadjeva
Mannan-binding lectin recognizes structures on ischaemic reperfused mouse kidneys and is implicated in tissue injury.
Scandinavian journal of immunology 2005;61(5):426-34.
2005: Anders Krarup; Uffe B Skov Sørensen; Misao Matsushita; Jens C Jensenius; Steffen Thiel
Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules mannan-binding lectin, L-ficolin, and H-ficolin.
Infection and immunity 2005;73(2):1052-60.
2004: Anders Krarup; Steffen Thiel; Annette Hansen; Teizo Fujita; Jens C Jensenius
L-ficolin is a pattern recognition molecule specific for acetyl groups.
The Journal of biological chemistry 2004;279(46):47513-9.
2004: Mihaela Gadjeva; Søren R Paludan; Steffen Thiel; V Slavov; Marieta M Ruseva; Kristina Eriksson; G-B Löwhagen; Lei Shi; Kazue Takahashi; AB Ezekowitz; Jens C Jensenius
Mannan-binding lectin modulates the response to HSV-2 infection.
Clinical and experimental immunology 2004;138(2):304-11.
2004: I A Kristensen; Steffen Thiel; R Steffensen; S Madhi; G Sorour; J Olsen
Mannan-binding lectin and RSV lower respiratory tract infection leading to hospitalization in children: a case-control study from Soweto, South Africa.
Scandinavian journal of immunology 2004;60(1-2):184-8.
2004: Mihaela Gadjeva; Kazue Takahashi; Steffen Thiel
Mannan-binding lectin--a soluble pattern recognition molecule.
Molecular immunology 2004;41(2-3):113-21.
2004: Lei Shi; Kazue Takahashi; Joseph Dundee; Sarit Shahroor-Karni; Steffen Thiel; Jens C Jensenius; Faten Gad; Michael Hamblin; Kedarnath N Sastry; R Alan B Ezekowitz
Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus.
The Journal of experimental medicine 2004;199(10):1379-90.
2004: Mihaela Gadjeva; Steffen Thiel; Jens C Jensenius
Assays for the mannan-binding lectin pathway.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2004;Chapter 13():Unit 13.6.
2003: Mette Møller-Kristensen; Jens C Jensenius; Lisbeth Jensen; Nicole M Thielens; Véronique Rossi; Gérard J Arlaud; Steffen Thiel
Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals.
Journal of immunological methods 2003;282(1-2):159-67.
2003: Troels Krarup Hansen; Steffen Thiel; Søren Tang Knudsen; Claus Gravholt; Jens Sandahl Christiansen; Carl Erik Mogensen; Per Løgstrup Poulsen
Elevated levels of mannan-binding lectin in patients with type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2003;88(10):4857-61.
2003: Kristian Stengaard-Pedersen; Steffen Thiel; Mihaela Gadjeva; Mette Møller-Kristensen; Rikke Sørensen; Lise T Jensen; Anders G Sjøholm; Lars Fugger; Jens C Jensenius
Inherited deficiency of mannan-binding lectin-associated serine protease 2.
The New England journal of medicine 2003;349(6):554-60.
2003: Jens C Jensenius; Poul Henning Jensen; K McGuire; J L Larsen; Steffen Thiel
Recombinant mannan-binding lectin (MBL) for therapy.
Biochemical Society transactions 2003;31(Pt 4):763-7.
2003: Cordula M Stover; Nicholas J Lynch; Mads R Dahl; S Hanson; M Takahashi; Marion Frankenberger; Loems Ziegler-Heitbrock; Ian C Eperon; Steffen Thiel; Wilhelm J Schwaeble
Murine serine proteases MASP-1 and MASP-3, components of the lectin pathway activation complex of complement, are encoded by a single structural gene.
Genes and immunity 2003;4(5):374-84.
2003: Mette Møller-Kristensen; Steffen Thiel; Annette G Hansen; Jens C Jensenius
On the site of C4 deposition upon complement activation via the mannan-binding lectin pathway or the classical pathway.
Scandinavian journal of immunology 2003;57(6):556-61.
2003: S Kielgast; Steffen Thiel; T B Henriksen; Torbjørn Bjerke; J Olsen; Jens C Jensenius
Umbilical cord mannan-binding lectin and infections in early childhood.
Scandinavian journal of immunology 2003;57(2):167-72.
2002: Wilhelm J Schwaeble; Mads R Dahl; Steffen Thiel; Cordula M Stover; Jens C Jensenius
The mannan-binding lectin-associated serine proteases (MASPs) and MAp19: four components of the lectin pathway activation complex encoded by two genes.
Immunobiology 2002;205(4-5):455-66.
2002: Steffen Thiel; Mette Møller-Kristensen; Lisbeth Jensen; Jens C Jensenius
Assays for the functional activity of the mannan-binding lectin pathway of complement activation.
Immunobiology 2002;205(4-5):446-54.
2002: Kazue Takahashi; Judith Gordon; Hong Liu; Kedarnath N Sastry; Judy E Epstein; Monica Motwani; Inga Laursen; Steffen Thiel; Jens C Jensenius; Michael Carroll; R Alan B Ezekowitz
Lack of mannose-binding lectin-A enhances survival in a mouse model of acute septic peritonitis.
Microbes and infection / Institut Pasteur 2002;4(8):773-84.
2001: Ilhan Celik; Cordula M Stover; M Botto; Steffen Thiel; sotiria tzima; D Künkel; M Walport; W Lorenz; Wilhelm J Schwaeble
Role of the classical pathway of complement activation in experimentally induced polymicrobial peritonitis.
Infection and immunity 2001;69(12):7304-9.
2001: Steen V Petersen; Steffen Thiel; Lisbeth Jensen; R Steffensen; Jens C Jensenius
An assay for the mannan-binding lectin pathway of complement activation.
Journal of immunological methods 2001;257(1-2):107-16.
2001: Steen V Petersen; Steffen Thiel; Jens C Jensenius
The mannan-binding lectin pathway of complement activation: biology and disease association.
Molecular immunology 2001;38(2-3):133-49.
2001: Mads R Dahl; Steffen Thiel; Misao Matsushita; Teizo Fujita; A C Willis; Tove Christensen; Thomas Vorup-Jensen; Jens C Jensenius
MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway.
Immunity 2001;15(1):127-35.
2001: Thomas Vorup-Jensen; Uffe B Jensen; H Liu; T Kawasaki; K Uemura; Steffen Thiel; Frederik Dagnaes-Hansen; Thomas G Jensen
Tail-vein injection of mannan-binding lectin DNA leads to high expression levels of multimeric protein in liver.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(6):867-74.
2001: Cordula M Stover; Y Endo; M Takahashi; Nicholas J Lynch; Cris S Constantinescu; Thomas Vorup-Jensen; Steffen Thiel; H Friedl; T Hankeln; R Hall; S Gregory; Teizo Fujita; Wilhelm J Schwaeble
The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.
Genes and immunity 2001;2(3):119-27.
2001: H Liu; Lisbeth Jensen; S Hansen; Steen V Petersen; Kazue Takahashi; AB Ezekowitz; F D Hansen; Jens C Jensenius; Steffen Thiel
Characterization and quantification of mouse mannan-binding lectins (MBL-A and MBL-C) and study of acute phase responses.
Scandinavian journal of immunology 2001;53(5):489-97.
2001: Nicole M Thielens; Sandor Cseh; Steffen Thiel; Thomas Vorup-Jensen; Véronique Rossi; Jens C Jensenius; Gérard J Arlaud
Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):5068-77.
2001: Thomas Vorup-Jensen; E S Sørensen; Uffe B Jensen; Wilhelm J Schwaeble; T Kawasaki; Y Ma; K Uemura; N Wakamiya; Y Suzuki; Thomas G Jensen; Kazue Takahashi; R Alan B Ezekowitz; Steffen Thiel; Jens C Jensenius
Recombinant expression of human mannan-binding lectin.
International immunopharmacology 2001;1(4):677-87.
2001: Mihaela Gadjeva; Steffen Thiel; Jens C Jensenius
The mannan-binding-lectin pathway of the innate immune response.
Current opinion in immunology 2001;13(1):74-8.
2000: Steen V Petersen; Steffen Thiel; Lisbeth Jensen; Thomas Vorup-Jensen; C Koch; Jens C Jensenius
Control of the classical and the MBL pathway of complement activation.
Molecular immunology 2000;37(14):803-11.
2000: Thomas Vorup-Jensen; Steen V Petersen; Annette G Hansen; K Poulsen; Wilhelm J Schwaeble; Robert B Sim; KB Reid; S J Davis; Steffen Thiel; Jens C Jensenius
Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):2093-100.
2000: Rudi Steffensen; Steffen Thiel; Kim Varming; C Jersild; Jens C Jensenius
Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers.
Journal of immunological methods 2000;241(1-2):33-42.
2000: Steffen Thiel; Steen V Petersen; Thomas Vorup-Jensen; Misao Matsushita; Teizo Fujita; Cordula M Stover; Wilhelm J Schwaeble; Jens C Jensenius
Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):878-87.
2000: S Hansen; Steffen Thiel; A Willis; Uffe Holmskov; Jens C Jensenius
Purification and characterization of two mannan-binding lectins from mouse serum.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2610-8.
1999: Cordula M Stover; Steffen Thiel; Nicholas J Lynch; Wilhelm J Schwaeble
The rat and mouse homologues of MASP-2 and MAp19, components of the lectin activation pathway of complement.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6848-59.
1999: Cordula M Stover; Steffen Thiel; M Thelen; Nicholas J Lynch; Thomas Vorup-Jensen; Jens C Jensenius; Wilhelm J Schwaeble
Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3481-90.
1999: Ole B Christiansen; DC Kilpatrick; V Souter; Kim Varming; Steffen Thiel; Jens C Jensenius
Mannan-binding lectin deficiency is associated with unexplained recurrent miscarriage.
Scandinavian journal of immunology 1999;49(2):193-6.
1999: Cordula M Stover; Wilhelm J Schwaeble; Nicholas J Lynch; Steffen Thiel; Michael R Speicher
Assignment of the gene encoding mannan-binding lectin-associated serine protease 2 (MASP2) to human chromosome 1p36.3-->p36.2 by in situ hybridization and somatic cell hybrid analysis.
Cytogenetics and cell genetics 1999;84(3-4):148-9.
1998: Thomas Vorup-Jensen; Jens C Jensenius; Steffen Thiel
MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway.
Immunobiology 1998;199(2):348-57.
1998: S B Laursen; TS Dalgaard; Steffen Thiel; B L Lim; T V Jensen; Helle R Juul-Madsen; A Takahashi; T Hamana; M Kawakami; Jens C Jensenius
Cloning and sequencing of a cDNA encoding chicken mannan-binding lectin (MBL) and comparison with mammalian analogues.
Immunology 1998;93(3):421-30.
1997: Steffen Thiel; Thomas Vorup-Jensen; Cordula M Stover; Wilhelm J Schwaeble; S B Laursen; K Poulsen; A C Willis; P Eggleton; S Hansen; Uffe Holmskov; KB Reid; Jens C Jensenius
A second serine protease associated with mannan-binding lectin that activates complement.
Nature 1997;386(6624):506-10.
1995: Steen B Laursen; J E Hedemand; Steffen Thiel; Antony C Willis; E Skriver; P S Madsen; Jens C Jensenius
Collectin in a non-mammalian species: isolation and characterization of mannan-binding protein (MBP) from chicken serum.
Glycobiology 1995;5(6):553-61.
1995: L Hynsjö; L Granberg; J Haurum; Steffen Thiel; Göran Larson
Use of factorial experimental design to delineate the strong calcium- and pH-dependent changes in binding of human surfactant protein-A to neutral glycosphingolipids--a model for studies of protein-carbohydrate interactions.
Analytical biochemistry 1995;225(2):305-14.
1995: Steffen Thiel; T Bjerke; D Hansen; L K Poulsen; Peter Oluf Schiøtz; Jens C Jensenius
Ontogeny of human mannan-binding protein, a lectin of the innate immune system.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 1995;6(1):20-3.
1994: R Malhotra; J S Haurum; Steffen Thiel; Robert B Sim
Binding of human collectins (SP-A and MBP) to influenza virus.
The Biochemical journal 1994;304 ( Pt 2)():455-61.
1994: L C van Emmerik; Ed J Kuijper; Cees A P Fijen; Jacob Dankert; Steffen Thiel
Binding of mannan-binding protein to various bacterial pathogens of meningitis.
Clinical and experimental immunology 1994;97(3):411-6.
1994: R Malhotra; Antony C Willis; A Lopez Bernal; Steffen Thiel; Robert B Sim
Mannan-binding protein levels in human amniotic fluid during gestation and its interaction with collectin receptor from amnion cells.
Immunology 1994;82(3):439-44.
1994: P B Fischer; Svend Ellermann-Eriksen; Steffen Thiel; Jens C Jensenius; Søren Mogensen
Mannan-binding protein and bovine conglutinin mediate enhancement of herpes simplex virus type 2 infection in mice.
Scandinavian journal of immunology 1994;39(5):439-45.
1994: Steen B Laursen; Steffen Thiel; Børge Teisner; Uffe Holmskov; Y Wang; Robert B Sim; Jens C Jensenius
Bovine conglutinin binds to an oligosaccharide determinant presented by iC3b, but not by C3, C3b or C3c.
Immunology 1994;81(4):648-54.
1994: P Holt; Uffe Holmskov; Steffen Thiel; Børge Teisner; Peter Højrup; Jens C Jensenius
Purification and characterization of mannan-binding protein from mouse serum.
Scandinavian journal of immunology 1994;39(2):202-8.
1993: J S Haurum; Steffen Thiel; I M Jones; P B Fischer; Steen B Laursen; Jens C Jensenius
Complement activation upon binding of mannan-binding protein to HIV envelope glycoproteins.
AIDS (London, England) 1993;7(10):1307-13.
1993: J Lu; H Wiedemann; Uffe Holmskov; Steffen Thiel; R Timpl; Kenneth B M Reid
Structural similarity between lung surfactant protein D and conglutinin. Two distinct, C-type lectins containing collagen-like sequences.
European journal of biochemistry / FEBS 1993;215(3):793-9.
1993: J S Haurum; Steffen Thiel; H P Haagsman; Steen B Laursen; B Larsen; Jens C Jensenius
Studies on the carbohydrate-binding characteristics of human pulmonary surfactant-associated protein A and comparison with two other collectins: mannan-binding protein and conglutinin.
The Biochemical journal 1993;293 ( Pt 3)():873-8.
1993: J Lu; Steen B Laursen; Steffen Thiel; Jens C Jensenius; Kenneth B M Reid
The cDNA cloning of conglutinin and identification of liver as a primary site of synthesis of conglutinin in members of the Bovidae.
The Biochemical journal 1993;292 ( Pt 1)():157-62.
1993: R Malhotra; J Haurum; Steffen Thiel; Jens C Jensenius; Robert B Sim
Pollen grains bind to lung alveolar type II cells (A549) via lung surfactant protein A (SP-A).
Bioscience reports 1993;13(2):79-90.
1992: Steffen Thiel; Uffe Holmskov; L Hviid; Steen B Laursen; Jens C Jensenius
The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response.
Clinical and experimental immunology 1992;90(1):31-5.
1992: Steffen Thiel
Mannan-binding protein, a complement activating animal lectin.
Immunopharmacology 1992;24(2):91-9.
1992: R Malhotra; J Haurum; Steffen Thiel; Robert B Sim
Interaction of C1q receptor with lung surfactant protein A.
European journal of immunology 1992;22(6):1437-45.
1990: R Malhotra; Steffen Thiel; Kenneth B M Reid; Robert B Sim
Human leukocyte C1q receptor binds other soluble proteins with collagen domains.
The Journal of experimental medicine 1990;172(3):955-9.
1990: P Friis-Christiansen; Steffen Thiel; S E Svehag; R Dessau; P Svendsen; Ove Andersen; Steen B Laursen; Jens C Jensenius
In vivo and in vitro antibacterial activity of conglutinin, a mammalian plasma lectin.
Scandinavian journal of immunology 1990;31(4):453-60.
1990: J H Lu; Steffen Thiel; H Wiedemann; R Timpl; Kenneth B M Reid
Binding of the pentamer/hexamer forms of mannan-binding protein to zymosan activates the proenzyme C1r2C1s2 complex, of the classical pathway of complement, without involvement of C1q.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(6):2287-94.
1987: Steffen Thiel; gunnar baatrup; P Friis-Christiansen; Sven-Erik Svehag; J C Jensenius
Characterization of a lectin in human plasma analogous to bovine conglutinin.
Scandinavian journal of immunology 1987;26(5):461-8.
1987: gunnar baatrup; Steffen Thiel; H Isager; Sven-Erik Svehag; J C Jensenius
Demonstration in human plasma of a lectin activity analogous to that of bovine conglutinin.
Scandinavian journal of immunology 1987;26(4):355-61.
1985: J C Jensenius; Steffen Thiel; gunnar baatrup; U Holmskov-Nielsen
Human conglutinin-like protein.
Bioscience reports 1985;5(10-11):901-5.