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Christoph Thiemermann

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D Frith; J C Goslings; C Gaarder; M Maegele; Mitchell J Cohen; S Allard; P I Johansson; S Stanworth; Christoph Thiemermann; Karim Brohi
Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations.
Tobias Eltze; Rainer Boer; Thomas Wagner; Steffen Weinbrenner; Michelle C McDonald; Christoph Thiemermann; Alexander Bürkle; Thomas Klein
Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors.
Pinpat Tripatara; Nimesh S A Patel; Massimo Collino; Margherita Gallicchio; Julius Kieswich; Sara Castiglia; Elisa Benetti; Keith N Stewart; Paul A J Brown; Mohammed M Yaqoob; Roberto Fantozzi; Christoph Thiemermann
Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunction.

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2010: D Frith; J C Goslings; C Gaarder; M Maegele; Mitchell J Cohen; S Allard; P I Johansson; S Stanworth; Christoph Thiemermann; Karim Brohi
Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations.
Journal of thrombosis and haemostasis : JTH 2010;8(9):1919-25.
2008: Tobias Eltze; Rainer Boer; Thomas Wagner; Steffen Weinbrenner; Michelle C McDonald; Christoph Thiemermann; Alexander Bürkle; Thomas Klein
Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors.
Molecular pharmacology 2008;74(6):1587-98.
2008: Pinpat Tripatara; Nimesh S A Patel; Massimo Collino; Margherita Gallicchio; Julius Kieswich; Sara Castiglia; Elisa Benetti; Keith N Stewart; Paul A J Brown; Mohammed M Yaqoob; Roberto Fantozzi; Christoph Thiemermann
Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunction.
Laboratory investigation; a journal of technical methods and pathology 2008;88(10):1038-48.
2008: Christoph Thiemermann
What's new in Shock, September 2008?
Shock (Augusta, Ga.) 2008;30(3):227-30.
2008: Massimo Collino; Christoph Thiemermann; Raffaella Mastrocola; Margherita Gallicchio; Elisa Benetti; Gianluca Miglio; Sara Castiglia; Oliviero Danni; Oliver Murch; Chiara Dianzani; Manuela Aragno; Roberto Fantozzi
Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus.
Shock (Augusta, Ga.) 2008;30(3):299-307.
2008: Michael Brines; Nimesh S A Patel; Pia Villa; Courtenay Brines; Tiziana Mennini; Massimiliano De Paola; Zubeyde Erbayraktar; Serhat Erbayraktar; Bruno Sepodes; Christoph Thiemermann; Pietro Ghezzi; Michael Yamin; Carla Hand; Qiao-Wen Xie; Thomas Coleman; Anthony Cerami
Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10925-30.
2008: Zoran Todorovic; Zorica Nesic; Radan Stojanović; Gordana Basta-Jovanović; Sanja Radojevic-Skodrić; Ruzca Velicković; Prabal K Chatterjee; Christoph Thiemermann; Milica Prostran
Acute protective effects of simvastatin in the rat model of renal ischemia-reperfusion injury: it is never too late for the pretreatment.
Journal of pharmacological sciences 2008;107(4):465-70.
2008: Christoph Thiemermann
What's new in Shock, April 2008?
Shock (Augusta, Ga.) 2008;29(4):427-30.
2008: Anders E Myhre; Joanna Agren; Maria K Dahle; Margareth V Tamburstuen; Ståle P Lyngstadaas; A Jon L Collins; Simon J Foster; Christoph Thiemermann; Ansgar O Aasen; Jacob E Wang
Liver X receptor is a key regulator of cytokine release in human monocytes.
Shock (Augusta, Ga.) 2008;29(4):468-74.
2008: Christoph Thiemermann
What's new in shock, March 2008.
Shock (Augusta, Ga.) 2008;29(3):311-4.
2008: Oliver Murch; Maha Abdelrahman; Amar Kapoor; Christoph Thiemermann
Muramyl dipeptide enhances the response to endotoxin to cause multiple organ injury in the anesthetized rat.
Shock (Augusta, Ga.) 2008;29(3):388-94.
2008: Oliver Murch; Maha Abdelrahman; Massimo Collino; Margherita Gallicchio; Elisa Benetti; Emanuela Mazzon; Roberto Fantozzi; Salvatore Cuzzocrea; Christoph Thiemermann
Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat.
Critical care medicine 2008;36(2):550-9.
2007: Salvatore Cuzzocrea; Giuseppe Malleo; Tiziana Genovese; Emanuela Mazzon; Emanuela Esposito; Carmelo Muià; Maha Abdelrahman; Rosanna Di Paola; Christoph Thiemermann
Effects of glycogen synthase kinase-3beta inhibition on the development of cerulein-induced acute pancreatitis in mice.
Critical care medicine 2007;35(12):2811-21.
2007: Tom E Ruud; Yngvar Gundersen; Jacob E Wang; Simon J Foster; Christoph Thiemermann; Ansgar O Aasen
Activation of cytokine synthesis by systemic infusions of lipopolysaccharide and peptidoglycan in a porcine model in vivo and in vitro.
Surgical infections 2007;8(5):495-503.
2007: Zhang Bao; Shuhui Lim; Wupeng LIAO; Yuzhi Lin; Christoph Thiemermann; Bernard P Leung; W S Fred Wong
Glycogen synthase kinase-3beta inhibition attenuates asthma in mice.
American journal of respiratory and critical care medicine 2007;176(5):431-8.
2007: Salvatore Cuzzocrea; Tiziana Genovese; Emanuela Mazzon; Emanuela Esposito; Carmelo Muià; Maha Abdelrahman; Rosanna Di Paola; Placido Bramanti; Christoph Thiemermann
Glycogen synthase kinase-3beta inhibition attenuates the development of bleomycin-induced lung injury.
International journal of immunopathology and pharmacology 2007;20(3):619-30.
2007: Gerd Albuszies; Josef Vogt; Ulrich Wachter; Christoph Thiemermann; Xavier M Leverve; Sandra Weber; Michael Georgieff; Peter Radermacher; Eberhard Barth
The effect of iNOS deletion on hepatic gluconeogenesis in hyperdynamic murine septic shock.
Intensive care medicine 2007;33(6):1094-101.
2007: Nimesh S A Patel; Salvatore Cuzzocrea; Massimo Collino; Prabal K Chaterjee; Emanuela Mazzon; Domenico Britti; Muhammad M Yaqoob; Christoph Thiemermann
The role of cycloxygenase-2 in the rodent kidney following ischaemia/reperfusion injury in vivo.
European journal of pharmacology 2007;562(1-2):148-54.
2007: Julia S Hadley; Jacob E Wang; Louis C Michaels; Charlotte M Dempsey; Simon J Foster; Christoph Thiemermann; Charles J Hinds
Alterations in inflammatory capacity and TLR expression on monocytes and neutrophils after cardiopulmonary bypass.
Shock (Augusta, Ga.) 2007;27(5):466-73.
2007: Christoph Thiemermann
What's new in shock, May 2007?
Shock (Augusta, Ga.) 2007;27(5):457-60.
2007: Salvatore Cuzzocrea; Emanuela Mazzon; Emanuela Esposito; Carmelo Muià; Maha Abdelrahman; Rosanna Di Paola; Concetta Crisafulli; Placido Bramanti; Christoph Thiemermann
Glycogen synthase kinase-3beta inhibition attenuates the development of ischaemia/reperfusion injury of the gut.
Intensive care medicine 2007;33(5):880-93.
2007: Neil Cartwright; Oliver Murch; Shaun K McMaster; Mark Paul-Clark; David A van Heel; Bernhard RYFFEL; Valerie QUESNIAUX; Timothy W Evans; Christoph Thiemermann; Jane A Mitchell
Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo.
American journal of respiratory and critical care medicine 2007;175(6):595-603.
2007: Laura Dugo; Marika Collin; Christoph Thiemermann
Glycogen synthase kinase 3beta as a target for the therapy of shock and inflammation.
Shock (Augusta, Ga.) 2007;27(2):113-23.
2007: Pinpat Tripatara; Nimesh S A Patel; Andrew Webb; Krishnaraj Rathod; Florence M J Lecomte; Emanuela Mazzon; Salvatore Cuzzocrea; Muhammad M Yaqoob; Amrita Ahluwalia; Christoph Thiemermann
Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase.
Journal of the American Society of Nephrology : JASN 2007;18(2):570-80.
2007: Christoph Thiemermann
Beneficial effects of erythropoietin in preclinical models of shock and organ failure.
Critical care (London, England) 2007;11(3):132.
2007: Laura Dugo; Marika Collin; David A Allen; Nimesh S A Patel; Inge Bauer; Eero Mervaala; Marjut Louhelainen; Simon J Foster; Muhammad M Yaqoob; Christoph Thiemermann
Inhibiting glycogen synthase kinase 3beta in sepsis.
Novartis Foundation symposium 2007;280():128-42; discussion 142-6, 160-4.
2007: Salvatore Cuzzocrea; Rosanna Di Paola; Emanuela Mazzon; Concetta Crisafulli; Tiziana Genovese; Carmelo Muià; Maha Abdelrahman; Emanuela Esposito; Christoph Thiemermann
Glycogen synthase kinase 3beta inhibition reduces the development of nonseptic shock induced by zymosan in mice.
Shock (Augusta, Ga.) 2007;27(1):97-107.
2007: Oliver Murch; Marika Collin; Christoph Thiemermann
Lysophosphatidic acid reduces the organ injury caused by endotoxemia-a role for G-protein-coupled receptors and peroxisome proliferator-activated receptor-gamma.
Shock (Augusta, Ga.) 2007;27(1):48-54.
2007: Oliver Murch; Marika Collin; Charles J Hinds; Christoph Thiemermann
Lipoproteins in inflammation and sepsis. I. Basic science.
Intensive care medicine 2007;33(1):13-24.
2006: Zorica Nesić; Zoran Todorović; Radan Stojanović; Gordana Basta-Jovanović; Sanja Radojević-Skodrić; Ruzica Velicković; Prabal K Chatterjee; Christoph Thiemermann; Milica Prostran
Single-dose intravenous simvastatin treatment attenuates renal injury in an experimental model of ischemia-reperfusion in the rat.
Journal of pharmacological sciences 2006;102(4):413-7.
2006: Bruno Sepodes; Rui Maio; Rui Pinto; Edward Sharples; Pedro Oliveira; Michelle McDonald; Muhammad Yaqoob; Christoph Thiemermann; Helder Mota-Filipe
Recombinant human erythropoietin protects the liver from hepatic ischemia-reperfusion injury in the rat.
Transplant international : official journal of the European Society for Organ Transplantation 2006;19(11):919-26.
2006: Salvatore Cuzzocrea; Concetta Crisafulli; Emanuela Mazzon; Emanuela Esposito; Carmelo Muià; Maha Abdelrahman; Rosanna Di Paola; Christoph Thiemermann
Inhibition of glycogen synthase kinase-3beta attenuates the development of carrageenan-induced lung injury in mice.
British journal of pharmacology 2006;149(6):687-702.
2006: James McCormick; Sean P Barry; Ahila Sivarajah; Giorgio Stefanutti; Paul A Townsend; Kevin M Lawrence; Simon Eaton; Richard A Knight; Christoph Thiemermann; David S Latchman; Anastasis Stephanou
Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2115-7.
2006: Massimo Collino; Manuela Aragno; Raffaella Mastrocola; Elisa Benetti; Margherita Gallicchio; Chiara Dianzani; Oliviero Danni; Christoph Thiemermann; Roberto Fantozzi
Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: effects of the PPAR-alpha agonist WY14643.
Free radical biology & medicine 2006;41(4):579-89.
2006: Ahila Sivarajah; Michelle C McDonald; Christoph Thiemermann
The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat.
Shock (Augusta, Ga.) 2006;26(2):154-61.
2006: Christoph Thiemermann
The spice of life: curcumin reduces the mortality associated with experimental sepsis.
Critical care medicine 2006;34(7):2009-11.
2006: J Agren; Christoph Thiemermann; Simon J Foster; Jacob E Wang; Ansgar O Aasen
Cytokine responses to CpG DNA in human leukocytes.
Scandinavian journal of immunology 2006;64(1):61-8.
2006: Oliver Murch; Marika Collin; Bruno Sepodes; Simon J Foster; Helder Mota-Filipe; Christoph Thiemermann
Lysophosphatidylcholine reduces the organ injury and dysfunction in rodent models of gram-negative and gram-positive shock.
British journal of pharmacology 2006;148(6):769-77.
2006: David Bar-Or; Michelle C McDonald; Christoph Thiemermann
Reduction of infarct size in a rat model of regional myocardial ischemia and reperfusion by the synthetic peptide DAHK.
Critical care medicine 2006;34(7):1955-9.
2006: Salvatore Cuzzocrea; Emanuela Mazzon; Rosanna Di Paola; Carmelo Muià; Concetta Crisafulli; Laura Dugo; Marika Collin; Domenico Britti; Achille P Caputi; Christoph Thiemermann
Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse.
Clinical immunology (Orlando, Fla.) 2006;120(1):57-67.
2006: Salvatore Cuzzocrea; Tiziana Genovese; Emanuela Mazzon; Concetta Crisafulli; Rosanna Di Paola; Carmelo Muià; Marika Collin; Emanuela Esposito; Placido Bramanti; Christoph Thiemermann
Glycogen synthase kinase-3 beta inhibition reduces secondary damage in experimental spinal cord trauma.
The Journal of pharmacology and experimental therapeutics 2006;318(1):79-89.
2006: Anders E Myhre; Staale Petter Lyngstadaas; Maria K Dahle; Jon Fredrik Stuestøl; Simon J Foster; Christoph Thiemermann; Per Lilleaasen; Jacob E Wang; Ansgar O Aasen
Anti-inflammatory properties of enamel matrix derivative in human blood.
Journal of periodontal research 2006;41(3):208-13.
2006: Laura Dugo; Maha Abdelrahman; Oliver Murch; Emanuela Mazzon; Salvatore Cuzzocrea; Christoph Thiemermann
Glycogen synthase kinase-3beta inhibitors protect against the organ injury and dysfunction caused by hemorrhage and resuscitation.
Shock (Augusta, Ga.) 2006;25(5):485-91.
2006: Laura Dugo; Marika Collin; David A Allen; Oliver Murch; Simon J Foster; Muhammad M Yaqoob; Christoph Thiemermann
Insulin reduces the multiple organ injury and dysfunction caused by coadministration of lipopolysaccharide and peptidoglycan independently of blood glucose: role of glycogen synthase kinase-3beta inhibition.
Critical care medicine 2006;34(5):1489-96.
2006: Salvatore Cuzzocrea; Rosanna Di Paola; Emanuela Mazzon; Nimesh S A Patel; Tiziana Genovese; Carmelo Muià; Concetta Crisafulli; Achille P Caputi; Christoph Thiemermann
Erythropoietin reduces the development of nonseptic shock induced by zymosan in mice.
Critical care medicine 2006;34(4):1168-77.
2006: Marika Collin; Oliver Murch; Christoph Thiemermann
Peroxisome proliferator-activated receptor-gamma antagonists GW9662 and T0070907 reduce the protective effects of lipopolysaccharide preconditioning against organ failure caused by endotoxemia.
Critical care medicine 2006;34(4):1131-8.
2006: Edward J Sharples; Christoph Thiemermann; Muhammad M Yaqoob
Novel applications of recombinant erythropoietin.
Current opinion in pharmacology 2006;6(2):184-9.
2006: Anders E Myhre; Ansgar O Aasen; Christoph Thiemermann; Jacob E Wang
Peptidoglycan--an endotoxin in its own right?
Shock (Augusta, Ga.) 2006;25(3):227-35.
2006: Brendan J R Whittle; Csaba Varga; Anikó Pósa; Andor Molnár; Marika Collin; Christoph Thiemermann
Reduction of experimental colitis in the rat by inhibitors of glycogen synthase kinase-3beta.
British journal of pharmacology 2006;147(5):575-82.
2006: Yun Yong Wang; Maria K Dahle; Joanna Agren; Anders E Myhre; Finn P Reinholt; Simon J Foster; Jon L Collins; Christoph Thiemermann; Ansgar O Aasen; Jacob E Wang
Activation of the liver X receptor protects against hepatic injury in endotoxemia by suppressing Kupffer cell activation.
Shock (Augusta, Ga.) 2006;25(2):141-6.
2006: Eberhard Barth; Peter Radermacher; Christoph Thiemermann; Sandra Weber; Michael Georgieff; Gerd Albuszies
Role of inducible nitric oxide synthase in the reduced responsiveness of the myocardium to catecholamines in a hyperdynamic, murine model of septic shock.
Critical care medicine 2006;34(2):307-13.
2006: Massimo Collino; Manuela Aragno; Raffaella Mastrocola; Margherita Gallicchio; Arianna Carolina Rosa; Chiara Dianzani; Oliviero Danni; Christoph Thiemermann; Roberto Fantozzi
Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion.
European journal of pharmacology 2006;530(1-2):70-80.
2005: Edward J Sharples; Christoph Thiemermann; Muhammad M Yaqoob
Mechanisms of disease: Cell death in acute renal failure and emerging evidence for a protective role of erythropoietin.
Nature clinical practice. Nephrology 2005;1(2):87-97.
2005: Marika Collin; Christoph Thiemermann
Hydrogen sulfide and sulfite: novel mediators in the pathophysiology of shock and inflammation.
Shock (Augusta, Ga.) 2005;24(6):595-6.
2005: Julia S Hadley; J E Wang; S J Foster; Christoph Thiemermann; Charles J Hinds
Peptidoglycan of Staphylococcus aureus upregulates monocyte expression of CD14, Toll-like receptor 2 (TLR2), and TLR4 in human blood: possible implications for priming of lipopolysaccharide signaling.
Infection and immunity 2005;73(11):7613-9.
2005: Marika Collin; Farhana Anuar; Oliver Murch; Madhav Bhatia; Philip K Moore; Christoph Thiemermann
Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia.
British journal of pharmacology 2005;146(4):498-505.
2005: Laura Dugo; Marika Collin; David A Allen; Nimesh S A Patel; Inge Bauer; Eero Mervaala; Marjut Louhelainen; Simon J Foster; Muhammad M Yaqoob; Christoph Thiemermann
GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat.
Critical care medicine 2005;33(9):1903-12.
2005: Yun Yong Wang; Anders E Myhre; Solveig Pettersen; Maria K Dahle; Simon J Foster; Christoph Thiemermann; Kristin Bjørnland; Ansgar O Aasen; Jacob E Wang
Peptidoglycan of Staphylococcus aureus induces enhanced levels of matrix metalloproteinase-9 in human blood originating from neutrophils.
Shock (Augusta, Ga.) 2005;24(3):214-8.
2005: Massimo Collino; Nimesh S A Patel; Kevin M Lawrence; Marika Collin; David S Latchman; Muhammad M Yaqoob; Christoph Thiemermann
The selective PPARgamma antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion.
Kidney international 2005;68(2):529-36.
2005: Ahila Sivarajah; Michelle C McDonald; Christoph Thiemermann
The cardioprotective effects of preconditioning with endotoxin, but not ischemia, are abolished by a peroxisome proliferator-activated receptor-gamma antagonist.
The Journal of pharmacology and experimental therapeutics 2005;313(2):896-901.
2005: Tiziana Genovese; Emanuela Mazzon; Rosanna Di Paola; Carmelo Muià; Michael Threadgill; Achille P Caputi; Christoph Thiemermann; Salvatore Cuzzocrea
Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury.
The Journal of pharmacology and experimental therapeutics 2005;313(2):529-38.
2005: Prabal K Chatterjee; Zoran Todorovic; Ahila Sivarajah; Helder Mota-Filipe; Paul A J Brown; Keith N Stewart; Emanuela Mazzon; Salvatore Cuzzocrea; Christoph Thiemermann
Inhibitors of calpain activation (PD150606 and E-64) and renal ischemia-reperfusion injury.
Biochemical pharmacology 2005;69(7):1121-31.
2005: Salvatore Cuzzocrea; Emanuela Mazzon; Rosanna Di Paola; Tiziana Genovese; Nimesh S A Patel; Domenico Britti; Massimo De Majo; Achille P Caputi; Christoph Thiemermann
Erythropoietin reduces the degree of arthritis caused by type II collagen in the mouse.
Arthritis and rheumatism 2005;52(3):940-50.
2005: Maha Abdelrahman; Ahila Sivarajah; Christoph Thiemermann
Beneficial effects of PPAR-gamma ligands in ischemia-reperfusion injury, inflammation and shock.
Cardiovascular research 2005;65(4):772-81.
2005: Nimesh S A Patel; Ulrich Cortes; Rosanna Di Poala; Emanuela Mazzon; Helder Mota-Filipe; Salvatore Cuzzocrea; Zhao-Qi Wang; Christoph Thiemermann
Mice lacking the 110-kD isoform of poly(ADP-ribose) glycohydrolase are protected against renal ischemia/reperfusion injury.
Journal of the American Society of Nephrology : JASN 2005;16(3):712-9.
2005: Nimesh S A Patel; Prabal K Chatterjee; Rosanna Di Paola; Emanuela Mazzon; Domenico Britti; Angelina De Sarro; Salvatore Cuzzocrea; Christoph Thiemermann
Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusion.
The Journal of pharmacology and experimental therapeutics 2005;312(3):1170-8.
2005: Tiziana Genovese; Salvatore Cuzzocrea; Rosanna Di Paola; Emanuela Mazzon; Claudio Mastruzzo; P Catalano; Maria Angela Sortino; Nunzio Crimi; Achille P Caputi; Christoph Thiemermann; Carlo Vancheri
Effect of rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 on bleomycin-induced lung injury.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2005;25(2):225-34.
2005: Maha Abdelrahman; Emanuela Mazzon; Michael Bauer; Inge Bauer; Sandrine Delbosc; Jean-Paul Cristol; Nimesh S A Patel; Salvatore Cuzzocrea; Christoph Thiemermann
Inhibitors of NADPH oxidase reduce the organ injury in hemorrhagic shock.
Shock (Augusta, Ga.) 2005;23(2):107-14.
2005: Tiziana Genovese; Emanuela Mazzon; Carmelo Muià; Nimesh S A Patel; Michael Threadgill; Placido Bramanti; Angela De Sarro; Christoph Thiemermann; Salvatore Cuzzocrea
Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma.
The Journal of pharmacology and experimental therapeutics 2005;312(2):449-57.
2005: Rosanna Di Paola; Emanuela Mazzon; Nimesh S A Patel; Tiziana Genovese; Carmelo Muià; Christoph Thiemermann; Angela De Sarro; Salvatore Cuzzocrea
Beneficial effects of GW274150 treatment on the development of experimental colitis induced by dinitrobenzene sulfonic acid.
European journal of pharmacology 2005;507(1-3):281-9.
2004: Salvatore Cuzzocrea; Emanuela Mazzon; Rosanna Di Paola; Tiziana Genovese; Nimesh S A Patel; Carmelo Muià; Michael Threadgill; Angela De Sarro; Christoph Thiemermann
5-Aminoisoquinolinone reduces colon injury by experimental colitis.
Naunyn-Schmiedeberg's archives of pharmacology 2004;370(6):464-73.
2004: Balázs Hauser; Peter Radermacher; Christoph Thiemermann; Martin Matejovic
Nitric oxide, bacteria, and host defense in sepsis: who needs what?
Shock (Augusta, Ga.) 2004;22(6):588-90.
2004: Maha Abdelrahman; Marika Collin; Christoph Thiemermann
The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock.
Shock (Augusta, Ga.) 2004;22(6):555-61.
2004: Salvatore Cuzzocrea; Emanuela Mazzon; Rosanna Di Paola; Nimesh S A Patel; Tiziana Genovese; Carmelo Muià; Angela De Sarro; Christoph Thiemermann
Erythropoietin reduces the development of experimental inflammatory bowel disease.
The Journal of pharmacology and experimental therapeutics 2004;311(3):1272-80.
2004: Marika Collin; Antonietta Rossi; Salvatore Cuzzocrea; Nimesh S A Patel; Rosanna Di Paola; Julia Hadley; Massimo Collino; Lidia Sautebin; Christoph Thiemermann
Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton.
Journal of leukocyte biology 2004;76(5):961-70.
2004: Prabal K Chatterjee; Zoran Todorovic; Ahila Sivarajah; Helder Mota-Filipe; Paul A J Brown; Keith N Stewart; Salvatore Cuzzocrea; Christoph Thiemermann
Differential effects of caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney.
European journal of pharmacology 2004;503(1-3):173-83.
2004: Virginie Pétrilli; Zdenko Herceg; Paul O Hassa; Nimesh S A Patel; Rosanna Di Paola; Ulrich Cortes; Laura Dugo; Helder-Mota Filipe; Christoph Thiemermann; Michael Hottiger; Salvatore Cuzzocrea; Zhao-Qi Wang
Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice.
The Journal of clinical investigation 2004;114(8):1072-81.
2004: Jacob E Wang; Solveig Pettersen; Jon Fredrik Stuestol; Yun Yong Wang; Simon J Foster; Christoph Thiemermann; Ansgar O Aasen; Kristin Bjørnland
Peptidoglycan of S. aureus causes increased levels of matrix metalloproteinases in the rat.
Shock (Augusta, Ga.) 2004;22(4):376-9.
2004: Laura Dugo; Marika Collin; Salvatore Cuzzocrea; Christoph Thiemermann
15d-prostaglandin J2 reduces multiple organ failure caused by wall-fragment of Gram-positive and Gram-negative bacteria.
European journal of pharmacology 2004;498(1-3):295-301.
2004: Nimesh S A Patel; Edward J Sharples; Salvatore Cuzzocrea; Prabal K Chatterjee; Domenico Britti; Muhammad M Yaqoob; Christoph Thiemermann
Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/reperfusion in the mouse kidney in vivo.
Kidney international 2004;66(3):983-9.
2004: Nimesh S A Patel; Marika Collin; Christoph Thiemermann
Urocortin does not reduce the renal injury and dysfunction caused by experimental ischaemia/reperfusion.
European journal of pharmacology 2004;496(1-3):175-80.
2004: Salvatore Cuzzocrea; Barbara Pisano; Laura Dugo; ANGELA IANARO; Nimesh S A Patel; Achille P Caputi; Christoph Thiemermann
Tempol reduces the activation of nuclear factor-kappaB in acute inflammation.
Free radical research 2004;38(8):813-9.
2004: Edward J Sharples; Nimesh Patel; Paul Brown; Keith Stewart; Helder Mota-Philipe; Michael T Sheaff; Julius Kieswich; David Allen; Steven M Harwood; Martin Raftery; Christoph Thiemermann; Muhammad M Yaqoob
Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion.
Journal of the American Society of Nephrology : JASN 2004;15(8):2115-24.
2004: Nimesh S A Patel; Salvatore Cuzzocrea; Prabal K Chatterjee; Rosanna Di Paola; Lidia Sautebin; Domenico Britti; Christoph Thiemermann
Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton.
Molecular pharmacology 2004;66(2):220-7.
2004: Christoph Thiemermann
Ligands of the peroxisome proliferator-activated receptor-gamma and heart failure.
British journal of pharmacology 2004;142(6):1049-51.
2004: Maha Abdelrahman; Edward J Sharples; Michelle C McDonald; Marika Collin; Nimesh S A Patel; Muhammad M Yaqoob; Christoph Thiemermann
Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemia.
Shock (Augusta, Ga.) 2004;22(1):63-9.
2004: Christoph Thiemermann
Inhibition of the activation of nuclear factor kappa B to reduce myocardial reperfusion injury and infarct size.
Cardiovascular research 2004;63(1):8-10.
2004: Rosanna Di Paola; Tiziana Genovese; Achille P Caputi; Michael Threadgill; Christoph Thiemermann; Salvatore Cuzzocrea
Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion.
European journal of pharmacology 2004;492(2-3):203-10.
2004: Bruno Sepodes; Rui Maio; Rui Pinto; C Marques; J Mendes-do-Vale; Michelle C McDonald; Christoph Thiemermann; Helder Mota-Filipe
Tempol, an intracelullar free radical scavenger, reduces liver injury in hepatic ischemia-reperfusion in the rat.
Transplantation proceedings 2004;36(4):849-53.
2004: Salvatore Cuzzocrea; Christoph Thiemermann; Daniela Salvemini
Potential therapeutic effect of antioxidant therapy in shock and inflammation.
Current medicinal chemistry 2004;11(9):1147-62.
2004: Salvatore Cuzzocrea; Barbara Pisano; Laura Dugo; ANGELA IANARO; Domenico Britti; Nimesh S A Patel; Rosanna Di Paola; Tiziana Genovese; Massimo Di Rosa; Achille P Caputi; Christoph Thiemermann
Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute pancreatitis induced by cerulein.
Intensive care medicine 2004;30(5):951-6.
2004: Salvatore Cuzzocrea; Laura Dugo; Nimesh S A Patel; Rosanna Di Paola; Gillian W Cockerill; Tiziana Genovese; Christoph Thiemermann
High-density lipoproteins reduce the intestinal damage associated with ischemia/reperfusion and colitis.
Shock (Augusta, Ga.) 2004;21(4):342-51.
2004: Saeed S Al-Ghamdi; Prabal K Chatterjee; Martin J Raftery; Christoph Thiemermann; Muhammad M Yaqoob
Role of cytochrome P4502E1 activation in proximal tubular cell injury induced by hydrogen peroxide.
Renal failure 2004;26(2):103-10.
2004: Marika Collin; Nimesh S A Patel; Laura Dugo; Christoph Thiemermann
Role of peroxisome proliferator-activated receptor-gamma in the protection afforded by 15-deoxydelta12,14 prostaglandin J2 against the multiple organ failure caused by endotoxin.
Critical care medicine 2004;32(3):826-31.
2004: Anders E Myhre; Jon Fredrik Stuestøl; Maria K Dahle; Gunhild Øverland; Christoph Thiemermann; Simon J Foster; Per Lilleaasen; Ansgar O Aasen; Jacob E Wang
Organ injury and cytokine release caused by peptidoglycan are dependent on the structural integrity of the glycan chain.
Infection and immunity 2004;72(3):1311-7.
2004: Aihua Wu; Charles J Hinds; Christoph Thiemermann
High-density lipoproteins in sepsis and septic shock: metabolism, actions, and therapeutic applications.
Shock (Augusta, Ga.) 2004;21(3):210-21.
2004: Prabal K Chatterjee; Nimesh S A Patel; Espen O Kvale; Paul A J Brown; Keith N Stewart; Helder Mota-Filipe; Martyn A Sharpe; Rosanna Di Paola; Salvatore Cuzzocrea; Christoph Thiemermann
EUK-134 reduces renal dysfunction and injury caused by oxidative and nitrosative stress of the kidney.
American journal of nephrology 2004;24(2):165-77.
2004: Marika Collin; Maha Abdelrahman; Christoph Thiemermann
Endogenous ligands of PPAR-gamma reduce the liver injury in haemorrhagic shock.
European journal of pharmacology 2004;486(2):233-5.
2004: Prabal K Chatterjee; Nimesh S A Patel; Salvatore Cuzzocrea; Paul A J Brown; Keith N Stewart; Helder Mota-Filipe; Domenico Britti; Wolfgang Eberhardt; Josef Pfeilschifter; Christoph Thiemermann
The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure.
Cardiovascular research 2004;61(3):630-43.
2004: Jacob E Wang; Maria K Dahle; Arne Yndestad; Inge Bauer; Michelle C McDonald; Pål Aukrust; Simon J Foster; Michael Bauer; Ansgar O Aasen; Christoph Thiemermann
Peptidoglycan of Staphylococcus aureus causes inflammation and organ injury in the rat.
Critical care medicine 2004;32(2):546-52.
2004: Salvatore Cuzzocrea; Barbara Pisano; Laura Dugo; ANGELA IANARO; Nimesh S A Patel; Rosanna Di Paola; Tiziana Genovese; Prabal K Chatterjee; Francesco Fulia; Elisabetta Cuzzocrea; Massimo Di Rosa; Achille P Caputi; Christoph Thiemermann
Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces the development of nonseptic shock induced by zymosan in mice.
Critical care medicine 2004;32(2):457-66.
2004: Prabal K Chatterjee; Bristi E Chatterjee; Helene Pedersen; Ahila Sivarajah; Michelle C McDonald; Helder Mota-Filipe; Paul A J Brown; Keith N Stewart; Salvatore Cuzzocrea; Michael Threadgill; Christoph Thiemermann
5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experimental ischemia/reperfusion.
Kidney international 2004;65(2):499-509.
2004: Salvatore Cuzzocrea; Barbara Pisano; Laura Dugo; ANGELA IANARO; Pasquale Maffia; Nimesh S A Patel; Rosanna Di Paola; Armando Ialenti; Tiziana Genovese; Prabal K Chatterjee; Massimo Di Rosa; Achille P Caputi; Christoph Thiemermann
Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation.
European journal of pharmacology 2004;483(1):79-93.
2004: Stefania Marzocco; Rosanna Di Paola; Giuseppina Autore; Emanuela Mazzon; Aldo Pinto; Achille P Caputi; Christoph Thiemermann; Salvatore Cuzzocrea
Calpain inhibitor I reduces intestinal ischemia-reperfusion injury in the rat.
Shock (Augusta, Ga.) 2004;21(1):38-44.
2004: Christoph Thiemermann
Ligands of the peroxisome proliferator-activated receptor-gamma and heart failure.
British journal of pharmacology 2004;141(1):1-3.
2003: Prabal K Chatterjee; Roberta d'Emmanuele di Villa Bianca; Ahila Sivarajah; Michelle C McDonald; Salvatore Cuzzocrea; Christoph Thiemermann
Pyrrolidine dithiocarbamate reduces renal dysfunction and injury caused by ischemia/reperfusion of the rat kidney.
European journal of pharmacology 2003;482(1-3):271-80.
2003: Thorsten Keller; Miriam Plesková; Michelle C McDonald; Christoph Thiemermann; Josef Pfeilschifter; Karl-Friedrich Beck
Identification of manganese superoxide dismutase as a NO-regulated gene in rat glomerular mesangial cells by 2D gel electrophoresis.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2003;9(4):183-93.
2003: Salvatore Cuzzocrea; Emanuela Mazzon; Laura Dugo; Nimesh S A Patel; Ivana Serraino; Rosanna Di Paola; Tiziana Genovese; Domenico Britti; Massimo De Maio; Achille P Caputi; Christoph Thiemermann
Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma.
Arthritis and rheumatism 2003;48(12):3544-56.
2003: Michelle C McDonald; Pal Dhadly; Gillian W Cockerill; Salvatore Cuzzocrea; Helder Mota-Filipe; Charles J Hinds; Norman E Miller; Christoph Thiemermann
Reconstituted high-density lipoprotein attenuates organ injury and adhesion molecule expression in a rodent model of endotoxic shock.
Shock (Augusta, Ga.) 2003;20(6):551-7.
2003: Prabal K Chatterjee; Christoph Thiemermann
Emerging drugs for renal failure.
Expert opinion on emerging drugs 2003;8(2):389-435.
2003: Jacob E Wang; Maria K Dahle; Michelle McDonald; Simon J Foster; Ansgar O Aasen; Christoph Thiemermann
Peptidoglycan and lipoteichoic acid in gram-positive bacterial sepsis: receptors, signal transduction, biological effects, and synergism.
Shock (Augusta, Ga.) 2003;20(5):402-14.
2003: Prabal K Chatterjee; Nimesh S A Patel; Espen O Kvale; Paul A J Brown; Keith N Stewart; Domenico Britti; Salvatore Cuzzocrea; Helder Mota-Filipe; Christoph Thiemermann
The tyrosine kinase inhibitor tyrphostin AG126 reduces renal ischemia/reperfusion injury in the rat.
Kidney international 2003;64(5):1605-19.
2003: Salvatore Cuzzocrea; Antonietta Rossi; Barbara Pisano; Rosanna Di Paola; Tiziana Genovese; Nimesh S A Patel; Elisabetta Cuzzocrea; ANGELA IANARO; Lidia Sautebin; Francesco Fulia; Prabal K Chatterjee; Achille P Caputi; Christoph Thiemermann
Pyrrolidine dithiocarbamate attenuates the development of organ failure induced by zymosan in mice.
Intensive care medicine 2003;29(11):2016-25.
2003: Prabal K Chatterjee; Espen O Kvale; Nimesh S A Patel; Christoph Thiemermann
GW274150 inhibits nitric oxide production by primary cultures of rat proximal tubular cells.
Medical science monitor : international medical journal of experimental and clinical research 2003;9(10):BR357-62.
2003: Carolina Muscoli; Salvatore Cuzzocrea; Dennis P Riley; Jay L Zweier; Christoph Thiemermann; Zhi-Qiang Wang; Daniela Salvemini
On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies.
British journal of pharmacology 2003;140(3):445-60.
2003: Salvatore Cuzzocrea; Barbara Pisano; Laura Dugo; ANGELA IANARO; Nimesh S A Patel; Rosanna Di Paola; Tiziana Genovese; Prabal K Chatterjee; Massimo Di Rosa; Achille P Caputi; Christoph Thiemermann
Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut.
British journal of pharmacology 2003;140(2):366-76.
2003: Michelle McDonald; Maha Abdelrahman; Salvatore Cuzzocrea; Christoph Thiemermann
Tyrphostin reduces the organ injury in haemorrhagic shock: role of inducible nitric oxide synthase.
Resuscitation 2003;58(3):349-61.
2003: Marika Collin; Christoph Thiemermann
The PPAR-gamma ligand 15-deoxy(delta12,14) prostaglandin J2 reduces the liver injury in endotoxic shock.
European journal of pharmacology 2003;476(3):257-8.
2003: Yun Wang; Chen-Fu Chang; Marisela Morales; Yung-Hsiao Chiang; Brandon K Harvey; Tsung-Ping Su; Li-I Tsao; Suyu Chen; Christoph Thiemermann
Diadenosine tetraphosphate protects against injuries induced by ischemia and 6-hydroxydopamine in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(21):7958-65.
2003: Ahila Sivarajah; Prabal K Chatterjee; Nimesh S A Patel; Zoran Todorovic; Yoshiyuki Hattori; Paul A J Brown; Keith N Stewart; Helder Mota-Filipe; Salvatore Cuzzocrea; Christoph Thiemermann
Agonists of peroxisome-proliferator activated receptor-gamma reduce renal ischemia/reperfusion injury.
American journal of nephrology 2003;23(4):267-76.
2003: Christoph Thiemermann; Nimesh S A Patel; Espen O Kvale; Gillian W Cockerill; Paul A J Brown; Keith N Stewart; Salvatore Cuzzocrea; Domenico Britti; Helder Mota-Filipe; Prabal K Chatterjee
High density lipoprotein (HDL) reduces renal ischemia/reperfusion injury.
Journal of the American Society of Nephrology : JASN 2003;14(7):1833-43.
2003: Nicole S Wayman; Belinda L Ellis; Christoph Thiemermann
Simvastatin reduces infarct size in a model of acute myocardial ischemia and reperfusion in the rat.
Medical science monitor : international medical journal of experimental and clinical research 2003;9(5):BR155-9.
2003: Michelle C McDonald; Roberta d'Emmanuele di Villa Bianca; Nicole S Wayman; Aldo Pinto; Martyn A Sharpe; Salvatore Cuzzocrea; Prabal K Chatterjee; Christoph Thiemermann
A superoxide dismutase mimetic with catalase activity (EUK-8) reduces the organ injury in endotoxic shock.
European journal of pharmacology 2003;466(1-2):181-9.
2003: Prabal K Chatterjee; Nimesh S A Patel; Ahila Sivarajah; Espen O Kvale; Laura Dugo; Salvatore Cuzzocrea; Paul A J Brown; Keith N Stewart; Helder Mota-Filipe; Domenico Britti; Muhammad M Yaqoob; Christoph Thiemermann
GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury.
Kidney international 2003;63(3):853-65.
2003: Salvatore Cuzzocrea; ANGELA IANARO; Nicole S Wayman; Emanuela Mazzon; Barbara Pisano; Laura Dugo; Ivana Serraino; Rosanna Di Paola; Prabal K Chatterjee; Massimo Di Rosa; Achille P Caputi; Christoph Thiemermann
The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat.
British journal of pharmacology 2003;138(4):678-88.
2003: Christoph Thiemermann
Protein tyrosine kinase inhibitors as novel therapeutics for systemic inflammation, shock, and organ injury.
Critical care medicine 2003;31(2):652-3.
2003: Gunhild Øverland; Sigfried Morath; Arne Yndestad; Thomas Hartung; Christoph Thiemermann; Simon J Foster; Bård Smedsrød; Øystein Mathisen; Pål Aukrust; Ansgar O Aasen; Jacob E Wang
Lipoteichoic acid is a potent inducer of cytokine production in rat and human Kupffer cells in vitro.
Surgical infections 2003;4(2):181-91.
2003: Prabal K Chatterjee; Christoph Thiemermann
An in vivo model of ischemia/reperfusion and inflammation of the kidneys of the rat.
Methods in molecular biology (Clifton, N.J.) 2003;225():223-37.
2003: Nicole S Wayman; Michelle C McDonald; Prabal K Chatterjee; Christoph Thiemermann
Models of coronary artery occlusion and reperfusion for the discovery of novel antiischemic and antiinflammatory drugs for the heart.
Methods in molecular biology (Clifton, N.J.) 2003;225():199-208.
2003: Christoph Thiemermann
Membrane-permeable radical scavengers (tempol) for shock, ischemia-reperfusion injury, and inflammation.
Critical care medicine 2003;31(1 Suppl):S76-84.
2002: Michelle C McDonald; M Izumi; Salvatore Cuzzocrea; Christoph Thiemermann
A novel, potent and selective inhibitor of the activity of inducible nitric oxide synthase (GW274150) reduces the organ injury in hemorrhagic shock.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2002;53(4 Pt 1):555-69.
2002: Ahila Sivarajah; Prabal K Chatterjee; Yoshiyuki Hattori; Paul A J Brown; Keith N Stewart; Zoran Todorovic; Helder Mota-Filipe; Christoph Thiemermann
Agonists of peroxisome-proliferator activated receptor-alpha (clofibrate and WY14643) reduce renal ischemia/reperfusion injury in the rat.
Medical science monitor : international medical journal of experimental and clinical research 2002;8(12):BR532-9.
2002: Nimesh S A Patel; Prabal K Chatterjee; Bristi E Chatterjee; Salvatore Cuzzocrea; Ivana Serraino; Paul A J Brown; Keith N Stewart; Helder Mota-Filipe; Christoph Thiemermann
TEMPONE reduces renal dysfunction and injury mediated by oxidative stress of the rat kidney.
Free radical biology & medicine 2002;33(11):1575-89.
2002: Helder Mota-Filipe; Bruno Sepodes; Michelle C McDonald; Salvatore Cuzzocrea; Rui Pinto; Christoph Thiemermann
The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat.
Medical science monitor : international medical journal of experimental and clinical research 2002;8(11):BR444-53.
2002: Salvatore Cuzzocrea; Prabal K Chatterjee; Emanuela Mazzon; Michelle C McDonald; Laura Dugo; Rosanna Di Paola; Ivana Serraino; Domenico Britti; Achille P Caputi; Christoph Thiemermann
Beneficial effects of GW274150, a novel, potent and selective inhibitor of iNOS activity, in a rodent model of collagen-induced arthritis.
European journal of pharmacology 2002;453(1):119-29.
2002: Salvatore Cuzzocrea; Prabal K Chatterjee; Emanuela Mazzon; Ivana Serraino; Laura Dugo; Tommaso Centorrino; Alberto Barbera; Antonio Ciccolo; Francesco Fulia; Michelle C McDonald; Achille P Caputi; Christoph Thiemermann
Effects of calpain inhibitor I on multiple organ failure induced by zymosan in the rat.
Critical care medicine 2002;30(10):2284-94.
2002: Prabal K Chatterjee; Kai Zacharowski; Salvatore Cuzzocrea; Paul A J Brown; Keith N Stewart; Helder Mota-Filipe; Christoph Thiemermann
Lipoteichoic acid from Staphylococcus aureus reduces renal ischemia/reperfusion injury.
Kidney international 2002;62(4):1249-63.
2002: Christoph Thiemermann
A vaccine to prevent infections with Staphylococcus aureus.
Medical science monitor : international medical journal of experimental and clinical research 2002;8(9):LE35-6.
2002: Maya Izumi; Michelle C McDonald; Martyn A Sharpe; Prabal K Chatterjee; Christoph Thiemermann
Superoxide dismutase mimetics with catalase activity reduce the organ injury in hemorrhagic shock.
Shock (Augusta, Ga.) 2002;18(3):230-5.
2002: Salvatore Cuzzocrea; Prabal K Chatterjee; Emanuela Mazzon; Laura Dugo; Angela De Sarro; Fons A J van de Loo; Achille P Caputi; Christoph Thiemermann
Role of induced nitric oxide in the initiation of the inflammatory response after postischemic injury.
Shock (Augusta, Ga.) 2002;18(2):169-76.
2002: Nicole S Wayman; Belinda L Ellis; Christoph Thiemermann
Ligands of the peroxisome proliferator-activated receptor-PPAR-a reduce myocardial infarct size.
Medical science monitor : international medical journal of experimental and clinical research 2002;8(7):BR243-7.
2002: Christoph Thiemermann
Interactions between lipoteichoic acid and peptidoglycan from Staphylococcus aureus: a structural and functional analysis.
Microbes and infection / Institut Pasteur 2002;4(9):927-35.
2002: Colin G M Millar; Christoph Thiemermann
Carboxy-PTIO, a scavenger of nitric oxide, selectively inhibits the increase in medullary perfusion and improves renal function in endotoxemia.
Shock (Augusta, Ga.) 2002;18(1):64-8.
2002: Nicole S Wayman; Yoshiyuki Hattori; Michelle C McDonald; Helder Mota-Filipe; Salvatore Cuzzocrea; Barbara Pisano; Prabal K Chatterjee; Christoph Thiemermann
Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(9):1027-40.
2002: Salvatore Cuzzocrea; Emanuela Mazzon; Laura Dugo; Tommaso Centorrino; Antonio Ciccolo; Michelle C McDonald; Angela De Sarro; Achille P Caputi; Christoph Thiemermann
Absence of endogenous interleukin-6 enhances the inflammatory response during acute pancreatitis induced by cerulein in mice.
Cytokine 2002;18(5):274-85.
2002: Laura Dugo; Prabal K Chatterjee; Emanuela Mazzon; Michelle C McDonald; R Di Paola; Francesco Fulia; Achille P Caputi; Christoph Thiemermann; Salvatore Cuzzocrea
The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat.
Intensive care medicine 2002;28(6):775-88.
2002: Salvatore Cuzzocrea; Emanuela Mazzon; Laura Dugo; Ivana Serraino; Tommaso Centorrino; Antonio Ciccolo; Fons A J van de Loo; Domenico Britti; Achille P Caputi; Christoph Thiemermann
Inducible nitric oxide synthase-deficient mice exhibit resistance to the acute pancreatitis induced by cerulein.
Shock (Augusta, Ga.) 2002;17(5):416-22.
2002: Espen Ellingsen; Siegfried Morath; Trude H Flo; Andra Schromm; Thomas Hartung; Christoph Thiemermann; Terje Espevik; Douglas T Golenbock; Daniel Foster; Rigmor Solberg; Ansgar O Aasen; Jacob Wang
Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.
Medical science monitor : international medical journal of experimental and clinical research 2002;8(5):BR149-56.
2002: Christoph Thiemermann
Development of novel, water-soluble inhibitors of poly (adenosine 5'-diphosphate ribose) synthetase activity for use in shock and ischemia-reperfusion injury.
Critical care medicine 2002;30(5):1163-5.
2002: Salvatore Cuzzocrea; Nicole S Wayman; Emanuela Mazzon; Laura Dugo; Rosanna Di Paola; Ivana Serraino; Domenico Britti; Prabal K Chatterjee; Achille P Caputi; Christoph Thiemermann
The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) attenuates the development of acute and chronic inflammation.
Molecular pharmacology 2002;61(5):997-1007.
2002: Prabal K Chatterjee; Nimesh S A Patel; Espen O Kvale; Salvatore Cuzzocrea; Paul A J Brown; Keith N Stewart; Helder Mota-Filipe; Christoph Thiemermann
Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury.
Kidney international 2002;61(3):862-71.
2002: Salvatore Cuzzocrea; Michelle C McDonald; Emanuela Mazzon; Laura Dugo; Ivana Serraino; Michael Threadgill; Achille P Caputi; Christoph Thiemermann
Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury.
Biochemical pharmacology 2002;63(2):293-304.
2002: Salvatore Cuzzocrea; Prabal K Chatterjee; Emanuela Mazzon; Laura Dugo; Ivana Serraino; Domenico Britti; Giuseppe Mazzullo; Achille P Caputi; Christoph Thiemermann
Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation.
British journal of pharmacology 2002;135(2):496-510.
2002: Roberta d'Emmanuele di Villa Bianca; Nicole S Wayman; Michelle C McDonald; Aldo Pinto; Martyn A Shape; Prabal K Chatterjee; Christoph Thiemermann
Superoxide dismutase mimetic with catalase activity, EUK-134, attenuates the multiple organ injury and dysfunction caused by endotoxin in the rat.
Medical science monitor : international medical journal of experimental and clinical research 2002;8(1):BR1-7.
2002: Kai Zacharowski; Prabal K Chatterjee; Christoph Thiemermann
Delayed preconditioning induced by lipoteichoic acid from B. subtilis and S. aureus is not blocked by administration of 5-hydroxydecanoate.
Shock (Augusta, Ga.) 2002;17(1):19-22.
2001: Nicole S Wayman; Michelle C McDonald; Andrew S Thompson; Michael Threadgill; Christoph Thiemermann
5-aminoisoquinolinone, a potent inhibitor of poly (adenosine 5'-diphosphate ribose) polymerase, reduces myocardial infarct size.
European journal of pharmacology 2001;430(1):93-100.
2001: Gillian W Cockerill; Michelle C McDonald; Helder Mota-Filipe; S Cuzzocrea; Norman E Miller; Christoph Thiemermann
High density lipoproteins reduce organ injury and organ dysfunction in a rat model of hemorrhagic shock.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(11):1941-52.
2001: Jacob E Wang; Pål Foyn Jørgensen; Espen Ellingsen; M Almiöf; Christoph Thiemermann; Simon J Foster; Ansgar O Aasen; Rigmor Solberg
Peptidoglycan primes for LPS-induced release of proinflammatory cytokines in whole human blood.
Shock (Augusta, Ga.) 2001;16(3):178-82.
2001: Kai Zacharowski; Reinhard Berkels; A Olbrich; P K Chatterjee; S Cuzzocrea; SJ Foster; Christoph Thiemermann
The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of Gram-positive and Gram-negative shock.
Critical care medicine 2001;29(8):1599-608.
2001: Prabal K Chatterjee; Paul A J Brown; Salvatore Cuzzocrea; Kai Zacharowski; Keith N Stewart; Helder Mota-Filipe; Michelle C McDonald; Christoph Thiemermann
Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat.
Kidney international 2001;59(6):2073-83.
2001: Pål Foyn Jørgensen; Jacob E Wang; M Almlöf; Christoph Thiemermann; Simon J Foster; Rigmor Solberg; Ansgar O Aasen
Peptidoglycan and lipoteichoic acid modify monocyte phenotype in human whole blood.
Clinical and diagnostic laboratory immunology 2001;8(3):515-21.
2001: Salvatore Cuzzocrea; Michelle C McDonald; Emanuela Mazzon; Helder Mota-Filipe; Tommaso Centorrino; Marialuisa Terranova; Antonio Ciccolo; Domenico Britti; Achille P Caputi; Christoph Thiemermann
Calpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the rat.
Gut 2001;48(4):478-88.
2001: Pål Foyn Jørgensen; Jacob E Wang; Rigmor Solberg; Christoph Thiemermann; Simon J Foster; Ansgar O Aasen
Procalcitonin does not influence the surface expression of inflammatory receptors on whole blood leukocytes.
Intensive care medicine 2001;27(2):430-3.
2001: GM Wray; S J Foster; CJ Hinds; Christoph Thiemermann
A cell wall component from pathogenic and non-pathogenic gram-positive bacteria (peptidoglycan) synergises with endotoxin to cause the release of tumour necrosis factor-alpha, nitric oxide production, shock, and multiple organ injury/dysfunction in the rat.
Shock (Augusta, Ga.) 2001;15(2):135-42.
2001: Pål Foyn Jørgensen; Jacob E Wang; M Almlöf; Rigmor Solberg; Cecilie Okkenhaug; Tim Scholz; Christoph Thiemermann; Simon J Foster; Ansgar O Aasen
Sirolimus interferes with the innate response to bacterial products in human whole blood by attenuation of IL-10 production.
Scandinavian journal of immunology 2001;53(2):184-91.
2001: Salvatore Cuzzocrea; Michelle C McDonald; Emanuela Mazzon; HM Filipe; Tommaso Centorrino; V Lepore; Marialuisa Terranova; Antonio Ciccolo; Achille P Caputi; Christoph Thiemermann
Beneficial effects of tempol, a membrane-permeable radical scavenger, on the multiple organ failure induced by zymosan in the rat.
Critical care medicine 2001;29(1):102-11.
2001: Michelle C McDonald; Helder Mota-Filipe; A Paul; Salvatore Cuzzocrea; Maha Abdelrahman; Steven M Harwood; R Plevin; Prabal K Chatterjee; Muhammad M Yaqoob; Christoph Thiemermann
Calpain inhibitor I reduces the activation of nuclear factor-kappaB and organ injury/dysfunction in hemorrhagic shock.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):171-186.
2000: Salvatore Cuzzocrea; Michelle C McDonald; Emanuela Mazzon; D Siriwardena; Ivana Serraino; Laura Dugo; Domenico Britti; Giuseppe Mazzullo; Achille P Caputi; Christoph Thiemermann
Calpain inhibitor I reduces the development of acute and chronic inflammation.
The American journal of pathology 2000;157(6):2065-79.
2000: Salvatore Cuzzocrea; Michelle C McDonald; Emanuela Mazzon; Laura Dugo; V Lepore; MT Fonti; Antonio Ciccolo; Marialuisa Terranova; Achille P Caputi; Christoph Thiemermann
Tempol, a membrane-permeable radical scavenger, reduces dinitrobenzene sulfonic acid-induced colitis.
European journal of pharmacology 2000;406(1):127-37.
2000: Salvatore Cuzzocrea; Michelle C McDonald; Emanuela Mazzon; Helder Mota-Filipe; V Lepore; Antonio Ciccolo; Marialuisa Terranova; Domenico Britti; Achille P Caputi; Christoph Thiemermann
The tyrosine kinase inhibitor tyrphostin AG 126 reduced the development of colitis in the rat.
Laboratory investigation; a journal of technical methods and pathology 2000;80(9):1439-53.
2000: Salvatore Cuzzocrea; Michelle C McDonald; Emanuela Mazzon; D Siriwardena; G Costantino; Francesco Fulia; Giovanni Cucinotta; Eloisa Gitto; Stefania P Cordaro; Ignazio Barberi; Angela De Sarro; Achille P Caputi; Christoph Thiemermann
Effects of tempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury.
Brain research 2000;875(1-2):96-106.
2000: Salvatore Cuzzocrea; Michelle C McDonald; Emanuela Mazzon; HM Filipe; G Costantino; Achille P Caputi; Christoph Thiemermann
Beneficial effects of tempol, a membrane-permeable radical scavenger, in a rodent model of splanchnic artery occlusion and reperfusion.
Shock (Augusta, Ga.) 2000;14(2):150-6.
2000: Prabal K Chatterjee; Salvatore Cuzzocrea; Paul A J Brown; Kai Zacharowski; Keith N Stewart; Helder Mota-Filipe; Christoph Thiemermann
Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat.
Kidney international 2000;58(2):658-73.
2000: Christoph Thiemermann; K Zacharowski
Selective activation of E-type prostanoid(3)-receptors reduces myocardial infarct size. A novel insight into the cardioprotective effects of prostaglandins.
Pharmacology & therapeutics 2000;87(1):61-7.
2000: Salvatore Cuzzocrea; Michelle C McDonald; Emanuela Mazzon; D Siriwardena; G Calabrò; Domenico Britti; Giuseppe Mazzullo; Angela De Sarro; Achille P Caputi; Christoph Thiemermann
The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammation.
The American journal of pathology 2000;157(1):145-58.
2000: Jacob E Wang; Pål Foyn Jørgensen; M Almlöf; Christoph Thiemermann; Simon J Foster; Ansgar O Aasen; Rigmor Solberg
Peptidoglycan and lipoteichoic acid from Staphylococcus aureus induce tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-10 production in both T cells and monocytes in a human whole blood model.
Infection and immunity 2000;68(7):3965-70.
2000: Kai Zacharowski; A Olbrich; S Cuzzocrea; SJ Foster; Christoph Thiemermann
Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of gram-positive shock.
Critical care medicine 2000;28(6):1953-61.
2000: Michelle C McDonald; Helder Mota-Filipe; J A Wright; Maha Abdelrahman; Michael Threadgill; Andrew S Thompson; Christoph Thiemermann
Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock.
British journal of pharmacology 2000;130(4):843-50.
2000: Kai Zacharowski; S Frank; M Otto; P K Chatterjee; S Cuzzocrea; G Hafner; J Pfeilschifter; Christoph Thiemermann
Lipoteichoic acid induces delayed protection in the rat heart: A comparison with endotoxin.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(6):1521-8.
2000: Prabal K Chatterjee; Kai Zacharowski; Salvatore Cuzzocrea; M Otto; Christoph Thiemermann
Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(5):641-51.
2000: Sebastian Walpen; Karl-Friedrich Beck; Wolfgang Eberhardt; M Apel; P K Chatterjee; G M Wray; Christoph Thiemermann; Josef Pfeilschifter
Downregulation of SPARC expression is mediated by nitric oxide in rat mesangial cells and during endotoxemia in the rat.
Journal of the American Society of Nephrology : JASN 2000;11(3):468-76.
2000: Salvatore Cuzzocrea; Michelle C McDonald; HM Filipe; G Costantino; Emanuela Mazzon; S Santagati; Achille P Caputi; Christoph Thiemermann
Effects of tempol, a membrane-permeable radical scavenger, in a rodent model of carrageenan-induced pleurisy.
European journal of pharmacology 2000;390(1-2):209-22.
2000: Salvatore Cuzzocrea; Michelle C McDonald; Helder Mota-Filipe; Emanuela Mazzon; G Costantino; Domenico Britti; Giuseppe Mazzullo; Achille P Caputi; Christoph Thiemermann
Beneficial effects of tempol, a membrane-permeable radical scavenger, in a rodent model of collagen-induced arthritis.
Arthritis and rheumatism 2000;43(2):320-8.
1999: Michelle C McDonald; HM Filipe; Christoph Thiemermann
Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the organ injury and dysfunction caused by haemorrhagic shock.
British journal of pharmacology 1999;128(6):1339-45.
1999: Kai Zacharowski; M Otto; G Hafner; H C Marsh; Christoph Thiemermann
Reduction of myocardial infarct size with sCR1sLe(x), an alternatively glycosylated form of human soluble complement receptor type 1 (sCR1), possessing sialyl Lewis x.
British journal of pharmacology 1999;128(5):945-52.
1999: Salvatore Cuzzocrea; Lidia Sautebin; G De Sarro; G Costantino; L Rombolà; Emanuela Mazzon; Armando Ialenti; Angela De Sarro; G Ciliberto; Massimo Di Rosa; Achille P Caputi; Christoph Thiemermann
Role of IL-6 in the pleurisy and lung injury caused by carrageenan.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):5094-104.
1999: Helder Mota-Filipe; Michelle C McDonald; Salvatore Cuzzocrea; Christoph Thiemermann
A membrane-permeable radical scavenger reduces the organ injury in hemorrhagic shock.
Shock (Augusta, Ga.) 1999;12(4):255-61.
1999: Michelle C McDonald; Kai Zacharowski; J Bowes; Salvatore Cuzzocrea; Christoph Thiemermann
Tempol reduces infarct size in rodent models of regional myocardial ischemia and reperfusion.
Free radical biology & medicine 1999;27(5-6):493-503.
1999: Kai Zacharowski; M Otto; G Hafner; P K Chatterjee; Christoph Thiemermann
Endotoxin induces a second window of protection in the rat heart as determined by using p-nitro-blue tetrazolium staining, cardiac troponin T release, and histology.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(9):2276-80.
1999: Kai Zacharowski; A Olbrich; J Piper; G Hafner; K Kondo; Christoph Thiemermann
Selective activation of the prostanoid EP(3) receptor reduces myocardial infarct size in rodents.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(9):2141-7.
1999: Prabal K Chatterjee; Salvatore Cuzzocrea; Christoph Thiemermann
Inhibitors of poly (ADP-ribose) synthetase protect rat proximal tubular cells against oxidant stress.
Kidney international 1999;56(3):973-84.
1999: Stefan Frank; Kai Zacharowski; G M Wray; Christoph Thiemermann; Josef Pfeilschifter
Identification of copper/zinc superoxide dismutase as a novel nitric oxide-regulated gene in rat glomerular mesangial cells and kidneys of endotoxemic rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(8):869-82.
1999: Kai Zacharowski; A Olbrich; Christoph Thiemermann
Reduction of myocardial injury by the EP3 receptor agonist TEI-3356. Role of protein kinase C and of K(ATP)-channels.
European journal of pharmacology 1999;367(1):33-9.
1999: Kai Zacharowski; A Olbrich; M Otto; G Hafner; Christoph Thiemermann
Effects of the prostanoid EP3-receptor agonists M&B 28767 and GR 63799X on infarct size caused by regional myocardial ischaemia in the anaesthetized rat.
British journal of pharmacology 1999;126(4):849-58.
1999: J Bowes; Michelle C McDonald; J Piper; Christoph Thiemermann
Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress.
Cardiovascular research 1999;41(1):126-34.
1998: P K Chatterjee; Christoph Thiemermann
Inhibitors of poly (ADP-ribose) synthetase protect rat renal proximal tubular cells against oxidant stress.
Biochemical Society transactions 1998;26(4):S318.
1998: J Bowes; H Ruetten; Piero Martorana; H Stockhausen; Christoph Thiemermann
Reduction of myocardial reperfusion injury by an inhibitor of poly (ADP-ribose) synthetase in the pig.
European journal of pharmacology 1998;359(2-3):143-50.
1998: M Leach; S Frank; A Olbrich; J Pfeilschifter; Christoph Thiemermann
Decline in the expression of copper/zinc superoxide dismutase in the kidney of rats with endotoxic shock: effects of the superoxide anion radical scavenger, tempol, on organ injury.
British journal of pharmacology 1998;125(4):817-25.
1998: J Bowes; J Piper; Christoph Thiemermann
Inhibitors of the activity of poly (ADP-ribose) synthetase reduce the cell death caused by hydrogen peroxide in human cardiac myoblasts.
British journal of pharmacology 1998;124(8):1760-6.
1998: K M Kengatharan; Sjef De Kimpe; C Robson; SJ Foster; Christoph Thiemermann
Mechanism of gram-positive shock: identification of peptidoglycan and lipoteichoic acid moieties essential in the induction of nitric oxide synthase, shock, and multiple organ failure.
The Journal of experimental medicine 1998;188(2):305-15.
1998: J Bowes; Christoph Thiemermann
Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the liver injury caused by ischaemia-reperfusion: a comparison with radical scavengers.
British journal of pharmacology 1998;124(6):1254-60.
1998: GM Wray; CJ Hinds; Christoph Thiemermann
Effects of inhibitors of poly(ADP-ribose) synthetase activity on hypotension and multiple organ dysfunction caused by endotoxin.
Shock (Augusta, Ga.) 1998;10(1):13-9.
1998: M Leach; L C Hamilton; A Olbrich; G M Wray; Christoph Thiemermann
Effects of inhibitors of the activity of cyclo-oxygenase-2 on the hypotension and multiple organ dysfunction caused by endotoxin: a comparison with dexamethasone.
British journal of pharmacology 1998;124(3):586-92.
1998: GM Wray; C G Millar; CJ Hinds; Christoph Thiemermann
Selective inhibition of the activity of inducible nitric oxide synthase prevents the circulatory failure, but not the organ injury/dysfunction, caused by endotoxin.
Shock (Augusta, Ga.) 1998;9(5):329-35.
1998: T Saetre; Yngvar Gundersen; Christoph Thiemermann; Per Lilleaasen; Ansgar O Aasen
Aminoethyl-isothiourea, a selective inhibitor of inducible nitric oxide synthase activity, improves liver circulation and oxygen metabolism in a porcine model of endotoxemia.
Shock (Augusta, Ga.) 1998;9(2):109-15.
1997: H Ruetten; Christoph Thiemermann
Endothelin-1 stimulates the biosynthesis of tumour necrosis factor in macrophages: ET-receptors, signal transduction and inhibition by dexamethasone.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1997;48(4):675-88.
1997: H Ruetten; Christoph Thiemermann
Combination immunotherapy which neutralises the effects of TNF alpha and IL-1 beta attenuates the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1997;48(4):605-21.
1997: H Ruetten; Christoph Thiemermann
Interleukin-13 is a more potent inhibitor of the expression of inducible nitric oxide synthase in smooth muscle cells than in macrophages: a comparison with interleukin-4 and interleukin-10.
Shock (Augusta, Ga.) 1997;8(6):409-14.
1997: H Ruetten; Christoph Thiemermann
Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase.
British journal of pharmacology 1997;122(1):59-70.
1997: C G Millar; Christoph Thiemermann
Intrarenal haemodynamics and renal dysfunction in endotoxaemia: effects of nitric oxide synthase inhibition.
British journal of pharmacology 1997;121(8):1824-30.
1997: H Ruetten; Christoph Thiemermann
Effect of calpain inhibitor I, an inhibitor of the proteolysis of I kappa B, on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat.
British journal of pharmacology 1997;121(4):695-704.
1997: Christoph Thiemermann; J Bowes; F P Myint; JR Vane
Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):679-83.
1996: K M Kengatharan; Sjef De Kimpe; Christoph Thiemermann
Role of nitric oxide in the circulatory failure and organ injury in a rodent model of gram-positive shock.
British journal of pharmacology 1996;119(7):1411-21.
1996: H Ruetten; Christoph Thiemermann
Effect of selective blockade of endothelin ETB receptors on the liver dysfunction and injury caused by endotoxaemia in the rat.
British journal of pharmacology 1996;119(3):479-86.
1996: H Ruetten; Christoph Thiemermann
Prevention of the expression of inducible nitric oxide synthase by aminoguanidine or aminoethyl-isothiourea in macrophages and in the rat.
Biochemical and biophysical research communications 1996;225(2):525-30.
1996: E J Hide; Christoph Thiemermann
Sulprostone-induced reduction of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels.
British journal of pharmacology 1996;118(6):1409-14.
1996: E J Hide; Christoph Thiemermann
Limitation of myocardial infarct size in the rabbit by ischaemic preconditioning is abolished by sodium 5-hydroxydecanoate.
Cardiovascular research 1996;31(6):941-6.
1996: H Ruetten; G J Southan; A Abate; Christoph Thiemermann
Attenuation of endotoxin-induced multiple organ dysfunction by 1-amino-2-hydroxy-guanidine, a potent inhibitor of inducible nitric oxide synthase.
British journal of pharmacology 1996;118(2):261-70.
1996: H Ruetten; Christoph Thiemermann; JR Vane
Effects of the endothelin receptor antagonist, SB 209670, on circulatory failure and organ injury in endotoxic shock in the anaesthetized rat.
British journal of pharmacology 1996;118(1):198-204.
1996: C C Wu; H Ruetten; Christoph Thiemermann
Comparison of the effects of aminoguanidine and N omega-nitro-L-arginine methyl ester on the multiple organ dysfunction caused by endotoxaemia in the rat.
European journal of pharmacology 1996;300(1-2):99-104.
1996: Pravit Akarasereenont; Christoph Thiemermann
The induction of cyclo-oxygenase-2 in human pulmonary epithelial cell culture (A549) activated by IL-1beta is inhibited by tyrosine kinase inhibitors.
Biochemical and biophysical research communications 1996;220(1):181-5.
1996: M Kengatharan; Sjef De Kimpe; Christoph Thiemermann
Analysis of the signal transduction in the induction of nitric oxide synthase by lipoteichoic acid in macrophages.
British journal of pharmacology 1996;117(6):1163-70.
1995: T Hohlfeld; P Klemm; Christoph Thiemermann; T D Warner; K Schrör; JR Vane
The contribution of tumour necrosis factor-alpha and endothelin-1 to the increase of coronary resistance in hearts from rats treated with endotoxin.
British journal of pharmacology 1995;116(8):3309-15.
1995: Sjef De Kimpe; Christoph Thiemermann; JR Vane
Role for intracellular platelet-activating factor in the circulatory failure in a model of gram-positive shock.
British journal of pharmacology 1995;116(8):3191-8.
1995: Christoph Thiemermann; H Ruetten; C C Wu; JR Vane
The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase.
British journal of pharmacology 1995;116(7):2845-51.
1995: E J Hide; J Piper; Christoph Thiemermann
Endothelin-1-induced reduction of myocardial infarct size by activation of ATP-sensitive potassium channels in a rabbit model of myocardial ischaemia and reperfusion.
British journal of pharmacology 1995;116(6):2597-602.
1995: E J Hide; P Ney; J Piper; Christoph Thiemermann; JR Vane
Reduction by prostaglandin E1 or prostaglandin E0 of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels.
British journal of pharmacology 1995;116(5):2435-40.
1995: Sjef De Kimpe; M Kengatharan; Christoph Thiemermann; JR Vane
The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10359-63.
1995: Y Hattori; Csaba Szabó; S Gross; Christoph Thiemermann; JR Vane
Lipid A and the lipid A analogue anti-tumour compound ONO-4007 induce nitric oxide synthase in vitro and in vivo.
European journal of pharmacology 1995;291(2):83-90.
1995: P Klemm; M Hecker; H Stockhausen; C C Wu; Christoph Thiemermann
Inhibition by N-acetyl-5-hydroxytryptamine of nitric oxide synthase expression in cultured cells and in the anaesthetized rat.
British journal of pharmacology 1995;115(7):1175-81.
1995: Pravit Akarasereenont; Y S Bakhle; Christoph Thiemermann; JR Vane
Cytokine-mediated induction of cyclo-oxygenase-2 by activation of tyrosine kinase in bovine endothelial cells stimulated by bacterial lipopolysaccharide.
British journal of pharmacology 1995;115(3):401-8.
1995: C C Wu; S J Chen; Csaba Szabó; Christoph Thiemermann; JR Vane
Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock.
British journal of pharmacology 1995;114(8):1666-72.
1995: Sjef De Kimpe; M L Hunter; C E Bryant; Christoph Thiemermann; JR Vane
Delayed circulatory failure due to the induction of nitric oxide synthase by lipoteichoic acid from Staphylococcus aureus in anaesthetized rats.
British journal of pharmacology 1995;114(6):1317-23.
1995: C C Wu; Christoph Thiemermann; JR Vane
Glibenclamide-induced inhibition of the expression of inducible nitric oxide synthase in cultured macrophages and in the anaesthetized rat.
British journal of pharmacology 1995;114(6):1273-81.
1995: Pravit Akarasereenont; J A Mitchell; Y S Bakhle; Christoph Thiemermann; JR Vane
Comparison of the induction of cyclooxygenase and nitric oxide synthase by endotoxin in endothelial cells and macrophages.
European journal of pharmacology 1995;273(1-2):121-8.
1995: M Kengatharan; B Battistini; T D Warner; Christoph Thiemermann; JR Vane
Endothelin-1 mediates the increase in ex vivo coronary vascular resistance induced by hemorrhagic shock in the anesthetized rat.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S422-4.
1995: Csaba Szabó; Christoph Thiemermann
Regulation of the expression of the inducible isoform of nitric oxide synthase.
Advances in pharmacology (San Diego, Calif.) 1995;34():113-53.
1995: Christoph Thiemermann
Selective inhibition of the activity of inducible nitric oxide synthase in septic shock.
Progress in clinical and biological research 1995;392():383-92.
1995: Pravit Akarasereenont; E Hide; P Ney; Christoph Thiemermann; JR Vane
The induction of cyclooxygenase-2 elicited by endotoxin in endothelial cells and macrophages is inhibited by prostaglandin E1 and 13,14-dihydro prostaglandin E1.
Agents and actions. Supplements 1995;45():59-64.
1995: G J Southan; Csaba Szabó; Christoph Thiemermann
Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity.
British journal of pharmacology 1995;114(2):510-6.
1994: Csaba Szabó; G J Southan; Christoph Thiemermann
Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12472-6.
1994: Pravit Akarasereenont; J A Mitchell; I Appleton; Christoph Thiemermann; JR Vane
Involvement of tyrosine kinase in the induction of cyclo-oxygenase and nitric oxide synthase by endotoxin in cultured cells.
British journal of pharmacology 1994;113(4):1522-8.
1994: Csaba Szabó; G J Southan; Christoph Thiemermann; JR Vane
The mechanism of the inhibitory effect of polyamines on the induction of nitric oxide synthase: role of aldehyde metabolites.
British journal of pharmacology 1994;113(3):757-66.
1994: G J Southan; Csaba Szabó; Christoph Thiemermann
Inhibition of the induction of nitric oxide synthase by spermine is modulated by aldehyde dehydrogenase.
Biochemical and biophysical research communications 1994;203(3):1638-44.
1994: Csaba Szabó; Christoph Thiemermann
Invited opinion: role of nitric oxide in hemorrhagic, traumatic, and anaphylactic shock and thermal injury.
Shock (Augusta, Ga.) 1994;2(2):145-55.
1994: L McMurdo; Christoph Thiemermann; JR Vane
The endothelin ETB receptor agonist, IRL 1620, causes vasodilatation and inhibits ex vivo platelet aggregation in the anaesthetised rabbit.
European journal of pharmacology 1994;259(1):51-5.
1994: Csaba Szabó; G J Southan; E Wood; Christoph Thiemermann; JR Vane
Inhibition by spermine of the induction of nitric oxide synthase in J774.2 macrophages: requirement of a serum factor.
British journal of pharmacology 1994;112(2):355-6.
1994: C C Wu; Csaba Szabó; S J Chen; Christoph Thiemermann; JR Vane
Activation of soluble guanylyl cyclase by a factor other than nitric oxide or carbon monoxide contributes to the vascular hyporeactivity to vasoconstrictor agents in the aorta of rats treated with endotoxin.
Biochemical and biophysical research communications 1994;201(1):436-42.
1994: L McMurdo; Christoph Thiemermann; JR Vane
The effects of the endothelin ETA receptor antagonist, FR 139317, on infarct size in a rabbit model of acute myocardial ischaemia and reperfusion.
British journal of pharmacology 1994;112(1):75-80.
1994: R P Wellings; Roger Corder; T D Warner; J P Cristol; Christoph Thiemermann; JR Vane
Evidence from receptor antagonists of an important role for ETB receptor-mediated vasoconstrictor effects of endothelin-1 in the rat kidney.
British journal of pharmacology 1994;111(2):515-20.
1994: Csaba Szabó; Christoph Thiemermann; C C Wu; M Perretti; JR Vane
Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):271-5.
1994: Christoph Thiemermann
The role of the L-arginine: nitric oxide pathway in circulatory shock.
Advances in pharmacology (San Diego, Calif.) 1994;28():45-79.
1993: J A Mitchell; Pravit Akarasereenont; Christoph Thiemermann; R J Flower; JR Vane
Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11693-7.
1993: Christoph Thiemermann
Drugs which modulate nitric oxide homeostasis are likely to provide therapeutic benefit in cardiovascular disease.
Cardiovascular research 1993;27(12):2104.
1993: Csaba Szabó; C C Wu; J A Mitchell; Steven S Gross; Christoph Thiemermann; JR Vane
Platelet-activating factor contributes to the induction of nitric oxide synthase by bacterial lipopolysaccharide.
Circulation research 1993;73(6):991-9.
1993: Csaba Szabó; C C Wu; Steven S Gross; Christoph Thiemermann; JR Vane
Interleukin-1 contributes to the induction of nitric oxide synthase by endotoxin in vivo.
European journal of pharmacology 1993;250(1):157-60.
1993: Csaba Szabó; Christoph Thiemermann; JR Vane
Dihydropyridine antagonists and agonists of calcium channels inhibit the induction of nitric oxide synthase by endotoxin in cultured macrophages.
Biochemical and biophysical research communications 1993;196(2):825-30.
1993: Csaba Szabó; Christoph Thiemermann; JR Vane
Inhibition of the production of nitric oxide and vasodilator prostaglandins attenuates the cardiovascular response to bacterial endotoxin in adrenalectomized rats.
Proceedings. Biological sciences / The Royal Society 1993;253(1338):233-8.
1993: Christoph Thiemermann; C C Wu; Csaba Szabó; M Perretti; JR Vane
Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock.
British journal of pharmacology 1993;110(1):177-82.
1993: L McMurdo; P S Lidbury; Christoph Thiemermann; JR Vane
Mediation of endothelin-1-induced inhibition of platelet aggregation via the ETB receptor.
British journal of pharmacology 1993;109(2):530-4.
1993: Csaba Szabó; J A Mitchell; Steven S Gross; Christoph Thiemermann; JR Vane
Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide.
The Journal of pharmacology and experimental therapeutics 1993;265(2):674-80.
1993: J P Cristol; Christoph Thiemermann; J A Mitchell; C Walder; JR Vane
Support of renal blood flow after ischaemic-reperfusion injury by endogenous formation of nitric oxide and of cyclo-oxygenase vasodilator metabolites.
British journal of pharmacology 1993;109(1):188-94.
1993: J P Cristol; T D Warner; Christoph Thiemermann; JR Vane
Mediation via different receptors of the vasoconstrictor effects of endothelins and sarafotoxins in the systemic circulation and renal vasculature of the anaesthetized rat.
British journal of pharmacology 1993;108(3):776-9.
1993: Csaba Szabó; J A Mitchell; Christoph Thiemermann; JR Vane
Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock.
British journal of pharmacology 1993;108(3):786-92.
1993: L McMurdo; Roger Corder; Christoph Thiemermann; JR Vane
Incomplete inhibition of the pressor effects of endothelin-1 and related peptides in the anaesthetized rat with BQ-123 provides evidence for more than one vasoconstrictor receptor.
British journal of pharmacology 1993;108(2):557-61.
1993: Christoph Thiemermann; Csaba Szabó; J A Mitchell; JR Vane
Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(1):267-71.
1993: L McMurdo; P S Lidbury; Roger Corder; Christoph Thiemermann; JR Vane
Heterogeneous receptors mediate endothelin-1-induced changes in blood pressure, hematocrit, and platelet aggregation.
Journal of cardiovascular pharmacology 1993;22 Suppl 8():S185-8.
1993: R P Wellings; T D Warner; Christoph Thiemermann; J P Cristol; Roger Corder; JR Vane
Vasoconstriction in the rat kidney induced by endothelin-1 is blocked by PD 145065.
Journal of cardiovascular pharmacology 1993;22 Suppl 8():S103-6.
1992: C E Walder; Christoph Thiemermann; JR Vane
NG-hydroxy-L-arginine prevents the haemodynamic effects of nitric oxide synthesis inhibition in the anaesthetized rat.
British journal of pharmacology 1992;107(2):476-80.
1992: R S Sprague; Christoph Thiemermann; JR Vane
Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and supports blood flow to hypoxic alveoli in anesthetized rabbits.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8711-5.
1991: Christoph Thiemermann; M Mustafa; P A Mester; J A Mitchell; M Hecker; JR Vane
Inhibition of the release of endothelium-derived relaxing factor in vitro and in vivo by dipeptides containing NG-nitro-L-arginine.
British journal of pharmacology 1991;104(1):31-8.
1991: C E Walder; Christoph Thiemermann; JR Vane
The involvement of endothelium-derived relaxing factor in the regulation of renal cortical blood flow in the rat.
British journal of pharmacology 1991;102(4):967-73.
1991: Christoph Thiemermann; S al-Damluji; M Hecker; JR Vane
FMRF-amide and L-Arg-L-Phe increase blood pressure and heart rate in the anaesthetised rat by central stimulation of the sympathetic nervous system.
Biochemical and biophysical research communications 1991;175(1):318-24.
1991: Christoph Thiemermann
Biosynthesis and interaction of endothelium-derived vasoactive mediators.
Eicosanoids 1991;4(4):187-202.
1990: C E Walder; Christoph Thiemermann; JR Vane
Endothelium-derived relaxing factor participates in the increased blood flow in response to pentagastrin in the rat stomach mucosa.
Proceedings. Biological sciences / The Royal Society 1990;241(1302):195-200.
1990: P S Lidbury; Christoph Thiemermann; R Korbut; JR Vane
Endothelins release tissue plasminogen activator and prostanoids.
European journal of pharmacology 1990;186(2-3):205-12.
1990: Christoph Thiemermann; JR Vane
Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo.
European journal of pharmacology 1990;182(3):591-5.
1990: M Hecker; J A Mitchell; H J Harris; M Katsura; Christoph Thiemermann; JR Vane
Endothelial cells metabolize NG-monomethyl-L-arginine to L-citrulline and subsequently to L-arginine.
Biochemical and biophysical research communications 1990;167(3):1037-43.
1990: Christoph Thiemermann; G R May; C P Page; JR Vane
Endothelin-1 inhibits platelet aggregation in vivo: a study with 111indium-labelled platelets.
British journal of pharmacology 1990;99(2):303-8.
1990: Roger Thomas; C E Walder; Christoph Thiemermann; JR Vane
Regional vascular resistance and haemodynamics in the spontaneously hypertensive rat: the effects of bradykinin.
Journal of cardiovascular pharmacology 1990;15(2):211-7.
1989: P S Lidbury; Christoph Thiemermann; Roger Thomas; JR Vane
Endothelin-3: selectivity as an anti-aggregatory peptide in vivo.
European journal of pharmacology 1989;166(2):335-8.
1989: Christoph Thiemermann; Roger Thomas; JR Vane
Defibrotide reduces infarct size in a rabbit model of experimental myocardial ischaemia and reperfusion.
British journal of pharmacology 1989;97(2):401-8.
1989: Christoph Thiemermann; Roger Thomas; JR Vane
Effects of defibrotide on infarct size and regional myocardial blood flow on the ischaemic reperfused rabbit heart.
Progress in clinical and biological research 1989;301():131-5.
1989: C E Walder; Roger Thomas; Christoph Thiemermann; JR Vane
The hemodynamic effects of endothelin-1 in the pithed rat.
Journal of cardiovascular pharmacology 1989;13 Suppl 5():S93-7; discussion S102.
1989: Christoph Thiemermann; P S Lidbury; Roger Thomas; JR Vane
Endothelin-1 releases prostacyclin and inhibits ex vivo platelet aggregation in the anesthetized rabbit.
Journal of cardiovascular pharmacology 1989;13 Suppl 5():S138-41; discussion S142.
1988: Christoph Thiemermann; P Lidbury; R Thomas; JR Vane
Endothelin inhibits ex vivo platelet aggregation in the rabbit.
European journal of pharmacology 1988;158(1-2):181-2.
1988: Roger Thomas; Christoph Thiemermann; C Walder; JR Vane
The effects of endothelium-dependent vasodilators on cardiac output and their distribution in the anaesthetized rat: a comparison with sodium nitroprusside.
British journal of pharmacology 1988;95(3):986-92.