FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Rolf Thieringer

Research Profile

Chemicals & Drugs

Living Beings

Disorders

Anatomy

Concepts & Ideas

Structure-Activity Relationship

Co-author Network

Publications

TOP 3
Mingjuan J Luo; Qi Luo; Milana M Maletic; Lorraine Malkowitz; Andrew Plump; Kashmira Shah; Irwin Singer; Martin S Springer; Serguei Stepaniants; Rolf Thieringer; Sherman T Waddell; James M Balkovec; Kang Cheng; Gloria J Ding; Cheryl B Le Grand; Anne Hermanowski-Vosatka; Douglas W Kawka; Gloria C Koo; Pek Yee Lum; Samuel D Wright; Kenneth K Wu; Xia Yang; Jeffrey Yuan; Jun Zhu; I-Ming Wang
11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature.
I-Ming Wang; Hilary A Wilkinson; Xia Yang; Jeffrey Yuan; Bin Zhang; Chunsheng Zhang; Jun Zhu; Pek Yee Lum; Mingjuan Jane Luo; Ernest Asante-Appiah; Yves Boie; Chi-Sung Chiu; Michael A Crackower; Hongyue Dai; Yudong He; Hani Houshyar; John Lamb; Qingying Meng; Chester Ni; Gary O'Neill; Mette Peters; Eric E Schadt; Deborah Slipetz; Serguei Stepaniants; Christopher M Tan; Rolf Thieringer; Christopher Roberts
Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers.
Milana Maletic; Aaron Leeman; Michael Szymonifka; Steven S Mundt; Hratch J Zokian; Kashmira Shah; Jasminka Dragovic; Kathy Lyons; Rolf Thieringer; Anne H Vosatka; James M Balkovec; Sherman Waddell
Bicyclo[2.2.2]octyltriazole inhibitors of 11β-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Rolf Thieringer (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Mingjuan J Luo; Qi Luo; Milana M Maletic; Lorraine Malkowitz; Andrew Plump; Kashmira Shah; Irwin Singer; Martin S Springer; Serguei Stepaniants; Rolf Thieringer; Sherman T Waddell; James M Balkovec; Kang Cheng; Gloria J Ding; Cheryl B Le Grand; Anne Hermanowski-Vosatka; Douglas W Kawka; Gloria C Koo; Pek Yee Lum; Samuel D Wright; Kenneth K Wu; Xia Yang; Jeffrey Yuan; Jun Zhu; I-Ming Wang
11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature.
Physiological genomics 2013;45(1):47-57.
2012: I-Ming Wang; Hilary A Wilkinson; Xia Yang; Jeffrey Yuan; Bin Zhang; Chunsheng Zhang; Jun Zhu; Pek Yee Lum; Mingjuan Jane Luo; Ernest Asante-Appiah; Yves Boie; Chi-Sung Chiu; Michael A Crackower; Hongyue Dai; Yudong He; Hani Houshyar; John Lamb; Qingying Meng; Chester Ni; Gary O'Neill; Mette Peters; Eric E Schadt; Deborah Slipetz; Serguei Stepaniants; Christopher M Tan; Rolf Thieringer; Christopher Roberts
Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers.
Molecular systems biology 2012;8():594.
2011: Milana Maletic; Aaron Leeman; Michael Szymonifka; Steven S Mundt; Hratch J Zokian; Kashmira Shah; Jasminka Dragovic; Kathy Lyons; Rolf Thieringer; Anne H Vosatka; James M Balkovec; Sherman Waddell
Bicyclo[2.2.2]octyltriazole inhibitors of 11β-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome.
Bioorganic & medicinal chemistry letters 2011;21(8):2568-72.
2010: Xia Yang; Larry Peterson; Rolf Thieringer; Joshua L Deignan; Xuping Wang; Jun Zhu; Susanna Wang; Hua Zhong; Serguei Stepaniants; John Beaulaurier; I-Ming Wang; Ray Rosa; Anne-Marie Cumiskey; Jane Ming-Juan Luo; Qi Luo; Kashmira Shah; Jianying Xiao; David Nickle; Andrew Plump; Eric E Schadt; Aldons J Lusis; Pek Yee Lum
Identification and validation of genes affecting aortic lesions in mice.
The Journal of clinical investigation 2010;120(7):2414-22.
2010: Magalie Berthiaume; Mathieu Laplante; William T Festuccia; Joel P Berger; Rolf Thieringer; Yves Deshaies
Preliminary report: pharmacologic 11beta-hydroxysteroid dehydrogenase type 1 inhibition increases hepatic fat oxidation in vivo and expression of related genes in rats fed an obesogenic diet.
Metabolism: clinical and experimental 2010;59(1):114-7.
2008: Yuping Zhu; Steven H Olson; Donald Graham; Gool Patel; Anne Hermanowski-Vosatka; Steven S Mundt; Kashmira Shah; Marty Springer; Rolf Thieringer; Samuel Wright; Jianying Xiao; Hratch Zokian; Jasminka Dragovic; James M Balkovec
Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
Bioorganic & medicinal chemistry letters 2008;18(11):3412-6.
2008: Yuping Zhu; Steven H Olson; Anne Hermanowski-Vosatka; Steven S Mundt; Kashmira Shah; Marty Springer; Rolf Thieringer; Samuel Wright; Jianying Xiao; Hratch Zokian; James M Balkovec
4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
Bioorganic & medicinal chemistry letters 2008;18(11):3405-11.
2008: Susan D Aster; Donald W Graham; Divya Kharbanda; Gool Patel; Mitree Ponpipom; Gina M Santorelli; Michael J Szymonifka; Steven S Mundt; Kashmira Shah; Martin S Springer; Rolf Thieringer; Anne Hermanowski-Vosatka; Samuel D Wright; Jianying Xiao; Hratch Zokian; James M Balkovec
Bis-aryl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Bioorganic & medicinal chemistry letters 2008;18(9):2799-804.
2007: Magalie Berthiaume; Mathieu Laplante; William T Festuccia; Katherine Cianflone; Lorraine P Turcotte; Denis R Joanisse; Gunilla Olivecrona; Rolf Thieringer; Yves Deshaies
11beta-HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues.
American journal of physiology. Endocrinology and metabolism 2007;293(4):E1045-52.
2007: Magalie Berthiaume; Mathieu Laplante; William T Festuccia; Yves Gélinas; Sébastien Poulin; Josée Lalonde; Denis R Joanisse; Rolf Thieringer; Yves Deshaies
Depot-specific modulation of rat intraabdominal adipose tissue lipid metabolism by pharmacological inhibition of 11beta-hydroxysteroid dehydrogenase type 1.
Endocrinology 2007;148(5):2391-7.
2005: Xin Gu; Jasminka Dragovic; Gloria C Koo; Sam L Koprak; Cheryl LeGrand; Steven S Mundt; Kashmira Shah; Martin S Springer; Eugene Y Tan; Rolf Thieringer; Anne Hermanowski-Vosatka; Hratch J Zokian; James M Balkovec; Sherman T Waddell
Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11beta-HSD1: novel therapeutic agents for the treatment of metabolic syndrome.
Bioorganic & medicinal chemistry letters 2005;15(23):5266-9.
2005: Steven Olson; Susan D Aster; Kai Brown; Linda Carbin; Donald W Graham; Anne Hermanowski-Vosatka; Cheryl B LeGrand; Steven S Mundt; Michael A Robbins; James M Schaeffer; Llnon H Slossberg; Michael J Szymonifka; Rolf Thieringer; Samuel D Wright; James M Balkovec
Adamantyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Bioorganic & medicinal chemistry letters 2005;15(19):4359-62.
2005: Rolf Thieringer; Anne Hermanowski-Vosatka
Inhibition of 11beta-HSD1 as a novel treatment for the metabolic syndrome: do glucocorticoids play a role?
Expert review of cardiovascular therapy 2005;3(5):911-24.
2005: Anne Hermanowski-Vosatka; James M Balkovec; Kang Cheng; Howard Y Chen; Melba Hernandez; Gloria C Koo; Cheryl B Le Grand; Zhihua Li; Joseph M Metzger; Steven S Mundt; Heather Noonan; Christian N Nunes; Steven H Olson; Bill Pikounis; Ning Ren; Nancy Robertson; James M Schaeffer; Kashmira Shah; Martin S Springer; Alison M Strack; Matthias Strowski; Kenneth Wu; Tsueiju Wu; Jianying Xiao; Bei B Zhang; Samuel D Wright; Rolf Thieringer
11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice.
The Journal of experimental medicine 2005;202(4):517-27.
2005: Steven S Mundt; Kelli Solly; Rolf Thieringer; Anne Hermanowski-Vosatka
Development and application of a scintillation proximity assay (SPA) for identification of selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Assay and drug development technologies 2005;3(4):367-75.
2005: Eric E Schadt; john lamb; Xia Yang; Jun Zhu; Stephen Wilton Edwards; Debraj GuhaThakurta; Solveig K Sieberts; Stephanie Monks; Marc Reitman; Chunsheng Zhang; Pek Yee Lum; Amy Leonardson; Rolf Thieringer; Joseph M Metzger; Liming Yang; John Castle; Haoyuan Zhu; Shera F Kash; Thomas A Drake; Alan Sachs; Aldons J Lusis
An integrative genomics approach to infer causal associations between gene expression and disease.
Nature genetics 2005;37(7):710-7.
2004: Jun Zhu; Pek Yee Lum; john lamb; Debraj GuhaThakurta; Stephen Wilton Edwards; Rolf Thieringer; Joel P Berger; M S Wu; J Thompson; Alan Sachs; Eric E Schadt
An integrative genomics approach to the reconstruction of gene networks in segregating populations.
Cytogenetic and genome research 2004;105(2-4):363-74.
2001: Rolf Thieringer; Cheryl B Le Grand; Linda Carbin; Tian-Quan Cai; Birming Wong; Samuel D Wright; Anne Hermanowski-Vosatka
11 Beta-hydroxysteroid dehydrogenase type 1 is induced in human monocytes upon differentiation to macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):30-5.
2001: Tian-Quan Cai; Birming Wong; Steven S Mundt; Rolf Thieringer; Samuel D Wright; Anne Hermanowski-Vosatka
Induction of 11beta-hydroxysteroid dehydrogenase type 1 but not -2 in human aortic smooth muscle cells by inflammatory stimuli.
The Journal of steroid biochemistry and molecular biology 2001;77(2-3):117-22.
2001: J Berger; Michael Tanen; Alex Elbrecht; Anne Hermanowski-Vosatka; David E Moller; Samuel D Wright; Rolf Thieringer
Peroxisome proliferator-activated receptor-gamma ligands inhibit adipocyte 11beta -hydroxysteroid dehydrogenase type 1 expression and activity.
The Journal of biological chemistry 2001;276(16):12629-35.
2000: Anne Hermanowski-Vosatka; David Gerhold; Steven S Mundt; V A Loving; M Lu; Y Chen; Alex Elbrecht; M Wu; Thomas W Doebber; L Kelly; Denise P Milot; Qiu Guo; Pei-ran Wang; Marc C Ippolito; Yu-Sheng Chao; Samuel D Wright; Rolf Thieringer
PPARalpha agonists reduce 11beta-hydroxysteroid dehydrogenase type 1 in the liver.
Biochemical and biophysical research communications 2000;279(2):330-6.
2000: Rolf Thieringer; Judy Fenyk-Melody; Cheryl B Le Grand; B A Shelton; Patricia A Detmers; Elizabeth P Somers; Linda Carbin; D E Moller; Samuel D Wright; Joel P Berger
Activation of peroxisome proliferator-activated receptor gamma does not inhibit IL-6 or TNF-alpha responses of macrophages to lipopolysaccharide in vitro or in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):1046-54.
1999: Thierry Vasselon; E Hailman; Rolf Thieringer; Patricia A Detmers
Internalization of monomeric lipopolysaccharide occurs after transfer out of cell surface CD14.
The Journal of experimental medicine 1999;190(4):509-21.
1999: Tian-Quan Cai; Nathalie Thieblemont; Birming Wong; Rolf Thieringer; B P Kennedy; Samuel D Wright
Enhancement of leukocyte response to lipopolysaccharide by secretory group IIA phospholipase A2.
Journal of leukocyte biology 1999;65(6):750-6.
1998: Patricia A Detmers; D Zhou; E Polizzi; Rolf Thieringer; William A Hanlon; Sanskruti Vaidya; Vinay S Bansal
Role of stress-activated mitogen-activated protein kinase (p38) in beta 2-integrin-dependent neutrophil adhesion and the adhesion-dependent oxidative burst.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):1921-9.
1998: Nathalie Thieblemont; Rolf Thieringer; Samuel D Wright
Innate immune recognition of bacterial lipopolysaccharide: dependence on interactions with membrane lipids and endocytic movement.
Immunity 1998;8(6):771-7.
1998: R Mark Wooten; TB Morrison; John H Weis; Samuel D Wright; Rolf Thieringer; Janis J Weis
The role of CD14 in signaling mediated by outer membrane lipoproteins of Borrelia burgdorferi.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(11):5485-92.
1997: M M Wurfel; Brian G Monks; Robin R Ingalls; R L Dedrick; RL Delude; D Zhou; Norbert Lamping; Ralf R Schumann; Rolf Thieringer; Matthew J Fenton; Samuel D Wright; Douglas T Golenbock
Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact.
The Journal of experimental medicine 1997;186(12):2051-6.
1995: RL Delude; R Savedra; H Zhao; Rolf Thieringer; S Yamamoto; Matthew J Fenton; Douglas T Golenbock
CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(20):9288-92.
1994: RL Delude; Matthew J Fenton; R Savedra; Pin-Yu Perera; Stefanie N Vogel; Rolf Thieringer; Douglas T Golenbock
CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity.
The Journal of biological chemistry 1994;269(35):22253-60.
1993: Rolf Thieringer; C R Raetz
Peroxisome-deficient Chinese hamster ovary cells with point mutations in peroxisome assembly factor-1.
The Journal of biological chemistry 1993;268(17):12631-6.