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Horst Thiermann

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Worek Franz; Timo Wille; Marianne Koller; Horst Thiermann
Structural requirements for effective oximes--evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes.
Raman Kumar Kalakuntla; Olivier Lafont; Romain Le Provost; Sophie Letort; Susanne Müller; Georg Reiter; Horst Thiermann; Timo Wille; Worek Franz; Géraldine Gouhier; François Estour
New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: evaluation of the detoxification using a half-quantitative enzymatic assay.
Susanne Müller; Horst Thiermann; Worek Franz; François Estour; Raman Kumar Kalakuntla; Olivier Lafont; Romain Le Provost; Georg Reiter
New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (II). In vitro detoxification of cyclosarin (GF): general screening and toxicokinetic aspects of OP scavengers.

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2013: Worek Franz; Timo Wille; Marianne Koller; Horst Thiermann
Structural requirements for effective oximes--evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes.
Chemico-biological interactions 2013;203(1):125-8.
2013: Raman Kumar Kalakuntla; Olivier Lafont; Romain Le Provost; Sophie Letort; Susanne Müller; Georg Reiter; Horst Thiermann; Timo Wille; Worek Franz; Géraldine Gouhier; François Estour
New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: evaluation of the detoxification using a half-quantitative enzymatic assay.
Toxicology letters 2013;216(2-3):200-5.
2013: Susanne Müller; Horst Thiermann; Worek Franz; François Estour; Raman Kumar Kalakuntla; Olivier Lafont; Romain Le Provost; Georg Reiter
New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (II). In vitro detoxification of cyclosarin (GF): general screening and toxicokinetic aspects of OP scavengers.
Toxicology letters 2013;216(2-3):206-12.
2012: Florian Brandhuber; Stefan Kubik; Luzian Porwol; Oliver Tenberken; Horst Thiermann; Worek Franz; Michael Zengerle; Georg Reiter
Detoxification of tabun at physiological pH mediated by substituted β-cyclodextrin and glucose derivatives containing oxime groups.
Toxicology 2012;302(2-3):163-71.
2012: Worek Franz; Jens von der Wellen; Kamil Kuca; Kamil Musilek; Horst Thiermann
Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase.
Archives of toxicology 2012;86(9):1379-86.
2012: Franz Worek; Timo Wille; Anne Bierwisch; Marianne Koller; Horst Thiermann
Kinetic interactions of a homologous series of bispyridinium monooximes (HGG oximes) with native and phosphonylated human acetylcholinesterase.
Toxicology letters 2012;212(1):29-32.
2012: Franz Worek; Timo Wille; Marianne Koller; Horst Thiermann
Reactivation kinetics of a series of related bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase--Structure-activity relationships.
Biochemical pharmacology 2012;83(12):1700-6.
2012: T Seeger; J E H Tattersall; Horst Thiermann; C M Timperley; M Bird; M Eichhorn; A C Green; M Lindner; K V Niessen; Worek Franz
Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro.
Toxicology 2012;294(2-3):80-4.
2012: Nadja M Herkert; Ulrich Kunz; Horst Thiermann; Gregor Freude; Worek Franz
Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase.
Toxicology letters 2012;209(2):173-8.
2012: K V Niessen; J E H Tattersall; Horst Thiermann; C M Timperley; M Bird; C Green; Worek Franz
Competition radioligand binding assays for the investigation of bispyridinium compound affinities to the human muscarinic acetylcholine receptor subtype 5 (hM(5) ).
Drug testing and analysis 2012;4(3-4):292-7.
2012: Marco Melzer; Horst Thiermann; Frederic Dorandeu; Jürgen Gäb; Anne Heidenreich; Kai Kehe; Thomas Letzel; Marc-Michael Blum
In vitro and in vivo efficacy of PEGylated diisopropyl fluorophosphatase (DFPase).
Drug testing and analysis 2012;4(3-4):262-70.
2012: Harald John; R Eddie Clutton; Michael Eddleston; Worek Franz; Horst Thiermann
Quantification of pralidoxime (2-PAM) in urine by ion pair chromatography-diode array detection: application to in vivo samples from minipig.
Drug testing and analysis 2012;4(3-4):169-78.
2012: Worek Franz; Peter Eyer; Horst Thiermann
Determination of acetylcholinesterase activity by the Ellman assay: a versatile tool for in vitro research on medical countermeasures against organophosphate poisoning.
Drug testing and analysis 2012;4(3-4):282-91.
2012: Harald John; John Mikler; Worek Franz; Horst Thiermann
Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine.
Drug testing and analysis 2012;4(3-4):194-8.
2011: Worek Franz; Horst Thiermann
Reactivation of organophosphate-inhibited human acetylcholinesterase by isonitrosoacetone (MINA): a kinetic analysis.
Chemico-biological interactions 2011;194(2-3):91-6.
2011: T Seeger; Worek Franz; R Bumm; H Friess; J Gerhardus; P Langer; A L Mihaljevic; K V Niessen; Horst Thiermann
Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6.
Toxicology letters 2011;206(1):72-6.
2011: Horst Thiermann; Worek Franz; Florian Eyer; Peter Eyer; Norbert Felgenhauer; Maria Radtke; Dirk Steinritz; Thomas Zilker
Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning.
Toxicology letters 2011;206(1):77-83.
2011: John Mikler; G Reiter; S Bohnert; M Garrett; Catherine Tenn; Horst Thiermann; Worek Franz; T W Sawyer
Immobilization of Russian VX skin depots by localized cooling: implications for decontamination and medical countermeasures.
Toxicology letters 2011;206(1):47-53.
2011: K V Niessen; T Seeger; J E H Tattersall; Horst Thiermann; C M Timperley; M Bird; C Green; Worek Franz
Interaction of bispyridinium compounds with the orthosteric binding site of human α7 and Torpedo californica nicotinic acetylcholine receptors (nAChRs).
Toxicology letters 2011;206(1):100-4.
2011: Berthold Drexler; Thomas Seeger; Horst Thiermann; Stefan Zinser; Bernd Antkowiak; Christian Grasshoff
Anaesthetic potency of diazepam is resistant to cholinergic overstimulation.
Toxicology letters 2011;206(1):84-8.
2011: Oliver Tenberken; Worek Franz; Horst Thiermann
Thirteenth International Medical Chemical Defence Conference 2011 "New developments in the treatment of intoxications by chemical warfare agents with focus on neurotoxic agents".
Toxicology letters 2011;206(1):3-4.
2011: Berthold Drexler; Christian Grasshoff; Thomas Seeger; Horst Thiermann; Bernd Antkowiak
Long-term evaluation of organophosphate toxicity and antidotal therapy in co-cultures of spinal cord and muscle tissue.
Toxicology letters 2011;206(1):89-93.
2011: N M Herkert; Horst Thiermann; Worek Franz
In vitro kinetic interactions of pyridostigmine, physostigmine and soman with erythrocyte and muscle acetylcholinesterase from different species.
Toxicology letters 2011;206(1):41-6.
2011: Georg Reiter; Horst Thiermann; Kendal Weatherby; Ira Hill; John Mikler; Worek Franz
Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(26):2704-13.
2011: Timo Wille; Horst Thiermann; Franz Worek
Evaluation of 6,6'-dithionicotinic acid as alternative chromogen in a modified Ellman method--comparison in various species.
Toxicology mechanisms and methods 2011;21(7):533-7.
2011: T W Sawyer; John Mikler; Worek Franz; G Reiter; Horst Thiermann; C Tenn; K Weatherby; S Bohnert
The therapeutic use of localized cooling in the treatment of VX poisoning.
Toxicology letters 2011;204(1):52-6.
2011: Worek Franz; Nadine Aurbek; Timo Wille; Peter Eyer; Horst Thiermann
Kinetic prerequisites of oximes as effective reactivators of organophosphate-inhibited acetylcholinesterase: a theoretical approach.
Journal of enzyme inhibition and medicinal chemistry 2011;26(3):303-8.
2011: N M Herkert; S Schulz; T Wille; Horst Thiermann; Rudolf A. Hatz; Worek Franz
Pre- and post-treatment effect of physostigmine on soman-inhibited human erythrocyte and muscle acetylcholinesterase in vitro.
Toxicology and applied pharmacology 2011;253(1):7-13.
2011: Timo Wille; Horst Thiermann; Worek Franz
In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases.
Chemico-biological interactions 2011;190(2-3):79-83.
2011: T Wille; Horst Thiermann; Worek Franz
Effect of different buffers on kinetic properties of human acetylcholinesterase and the interaction with organophosphates and oximes.
Archives of toxicology 2011;85(3):193-8.
2011: Susanne Müller; Marianne Koller; Romain Le Provost; Olivier Lafont; François Estour; Timo Wille; Horst Thiermann; Worek Franz; Georg Reiter
In vitro detoxification of cyclosarin (GF) by modified cyclodextrins.
Toxicology letters 2011;200(1-2):53-8.
2011: Worek Franz; Nadine Aurbek; Timo Wille; Peter Eyer; Horst Thiermann
Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase.
Toxicology letters 2011;200(1-2):19-23.
2011: Timo Wille; Sascha Gonder; Ursula Rauen; Thomas Seeger; Horst Thiermann; Franz Worek
Evaluation of functional and structural alterations in muscle tissue after short-term cold storage in a new tissue preservation solution.
Cells, tissues, organs 2011;194(6):501-9.
2010: Worek Franz; Timo Wille; Nadine Aurbek; Peter Eyer; Horst Thiermann
Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach.
Toxicology and applied pharmacology 2010;249(3):231-7.
2010: Dirk Steinritz; Birgit Bölck; Jana Schwarz; Frank Balszuweit; Sandra Dühr; Marwa Ibrahim; Wilhelm Bloch; Horst Thiermann; Kai Kehe
Effect of N-acetyl cysteine and alpha-linolenic acid on sulfur mustard caused impairment of in vitro endothelial tube formation.
Toxicological sciences : an official journal of the Society of Toxicology 2010;118(2):521-9.
2010: Harald John; Florian Eyer; Thomas Zilker; Horst Thiermann
High-performance liquid-chromatographic tandem-mass spectrometric methods for atropinesterase-mediated enantioselective and chiral determination of R- and S-hyoscyamine in plasma.
Analytica chimica acta 2010;680(1-2):32-40.
2010: Harald John; Felicitas Breyer; Jörg Oliver Thumfart; Hans Höchstetter; Horst Thiermann
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for detection and identification of albumin phosphylation by organophosphorus pesticides and G- and V-type nerve agents.
Analytical and bioanalytical chemistry 2010;398(6):2677-91.
2010: Berthold Drexler; Bernd Antkowiak; Horst Thiermann; Thomas Seeger; Christian Grasshoff
Interactions between atropine and etomidate in cortical and spinal networks during cholinergic crisis.
Toxicology letters 2010;198(3):342-7.
2010: Oliver Tenberken; John Mikler; I Hill; K Weatherby; Horst Thiermann; Worek Franz; G Reiter
Toxicokinetics of tabun enantiomers in anaesthetized swine after intravenous tabun administration.
Toxicology letters 2010;198(2):177-81.
2010: Timo Wille; Fredrik Ekström; Jong-Cheol Lee; Yuan-Ping Pang; Horst Thiermann; Worek Franz
Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds.
Biochemical pharmacology 2010;80(6):941-6.
2010: Nadine Aurbek; Nadja M Herkert; Marianne Koller; Horst Thiermann; Worek Franz
Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship?
Chemico-biological interactions 2010;187(1-3):215-9.
2010: Horst Thiermann; Thomas Seeger; Sascha Gonder; Nadja Herkert; Bernd Antkowiak; Thomas Zilker; Florian Eyer; Worek Franz
Assessment of neuromuscular dysfunction during poisoning by organophosphorus compounds.
Chemico-biological interactions 2010;187(1-3):265-9.
2010: Worek Franz; Nadine Aurbek; Nadja M Herkert; Harald John; Michael Eddleston; Peter Eyer; Horst Thiermann
Evaluation of medical countermeasures against organophosphorus compounds: the value of experimental data and computer simulations.
Chemico-biological interactions 2010;187(1-3):259-64.
2010: Peter Eyer; Worek Franz; Horst Thiermann; Michael Eddleston
Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning.
Chemico-biological interactions 2010;187(1-3):270-8.
2010: Horst Thiermann; Florian Eyer; Norbert Felgenhauer; Rudolf Pfab; Thomas Zilker; Peter Eyer; Worek Franz
Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds.
Toxicology letters 2010;197(3):236-42.
2010: Mirko Papritz; Christine Pohl; Christoph Wübbeke; Michaela Moisch; Helene Hofmann; Maria Iris Hermanns; Horst Thiermann; Charles James Kirkpatrick; Kai Kehe
Side-specific effects by cadmium exposure: apical and basolateral treatment in a coculture model of the blood-air barrier.
Toxicology and applied pharmacology 2010;245(3):361-9.
2010: Horst Thiermann; Peter Eyer; Worek Franz
Muscle force and acetylcholinesterase activity in mouse hemidiaphragms exposed to paraoxon and treated by oximes in vitro.
Toxicology 2010;272(1-3):46-51.
2010: Oliver Tenberken; Horst Thiermann; Worek Franz; G Reiter
Chromatographic preparation and kinetic analysis of interactions between tabun enantiomers and acetylcholinesterase.
Toxicology letters 2010;195(2-3):142-6.
2010: Harald John; Michael Eddleston; R Eddie Clutton; Worek Franz; Horst Thiermann
Simultaneous quantification of the organophosphorus pesticides dimethoate and omethoate in porcine plasma and urine by LC-ESI-MS/MS and flow-injection-ESI-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(17-18):1234-45.
2010: Marianne Koller; Christian Becker; Horst Thiermann; Worek Franz
GC-MS and LC-MS analysis of nerve agents in body fluids: intra-laboratory verification test using spiked plasma and urine samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(17-18):1226-33.
2010: Oliver Tenberken; Worek Franz; Horst Thiermann; Georg Reiter
Development and validation of a sensitive gas chromatography-ammonia chemical ionization mass spectrometry method for the determination of tabun enantiomers in hemolysed blood and plasma of different species.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(17-18):1290-6.
2010: Nadja M Herkert; Nadine Aurbek; Peter Eyer; Horst Thiermann; Worek Franz
Comparative study of oxime-induced reactivation of erythrocyte and muscle AChE from different animal species following inhibition by sarin or paraoxon.
Toxicology letters 2010;194(3):94-101.
2010: Berthold Drexler; Bernd Antkowiak; Horst Thiermann; Christian Grasshoff
Atropine increases sevoflurane potency in cortical but not spinal networks during cholinergic overstimulation.
Toxicology 2010;268(1-2):98-103.
2010: Harald John; Tobias Binder; Hans Höchstetter; Horst Thiermann
LC-ESI MS/MS quantification of atropine and six other antimuscarinic tropane alkaloids in plasma.
Analytical and bioanalytical chemistry 2010;396(2):751-63.
2009: Horst Thiermann; Thomas Zilker; Florian Eyer; Norbert Felgenhauer; Peter Eyer; Worek Franz
Monitoring of neuromuscular transmission in organophosphate pesticide-poisoned patients.
Toxicology letters 2009;191(2-3):297-304.
2009: A Heinrich; F Balszuweit; Horst Thiermann; Kai Kehe
Rapid simultaneous determination of apoptosis, necrosis, and viability in sulfur mustard exposed HaCaT cell cultures.
Toxicology letters 2009;191(2-3):260-7.
2009: T Wille; O Tenberken; G Reiter; S Müller; R Le Provost; O Lafont; F Estour; Horst Thiermann; Worek Franz
Detoxification of nerve agents by a substituted beta-cyclodextrin: application of a modified biological assay.
Toxicology 2009;265(3):96-100.
2009: Horst Thiermann; Worek Franz; Peter Eyer; Florian Eyer; Norbert Felgenhauer; Thomas Zilker
Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships.
Clinical toxicology (Philadelphia, Pa.) 2009;47(8):807-13.
2009: Florian Eyer; Worek Franz; Peter Eyer; Norbert Felgenhauer; Mike Haberkorn; Thomas Zilker; Horst Thiermann
Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness.
Clinical toxicology (Philadelphia, Pa.) 2009;47(8):798-806.
2009: Kai Kehe; F Balszuweit; Dirk Steinritz; Horst Thiermann
Molecular toxicology of sulfur mustard-induced cutaneous inflammation and blistering.
Toxicology 2009;263(1):12-9.
2009: Mike Rowell; Kai Kehe; Frank Balszuweit; Horst Thiermann
The chronic effects of sulfur mustard exposure.
Toxicology 2009;263(1):9-11.
2009: Kai Kehe; Horst Thiermann; F Balszuweit; Florian Eyer; Dirk Steinritz; Thomas Zilker
Acute effects of sulfur mustard injury--Munich experiences.
Toxicology 2009;263(1):3-8.
2009: Florian Eyer; Darren M Roberts; Nicholas A Buckley; Michael Eddleston; Horst Thiermann; Worek Franz; Peter Eyer
Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF).
Biochemical pharmacology 2009;78(5):531-7.
2009: Dirk Steinritz; A Elischer; F Balszuweit; S Gonder; A Heinrich; Wilhelm Bloch; Horst Thiermann; Kai Kehe
Sulphur mustard induces time- and concentration-dependent regulation of NO-synthesizing enzymes.
Toxicology letters 2009;188(3):263-9.
2009: Worek Franz; N M Herkert; Marianne Koller; Nadine Aurbek; Horst Thiermann
Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study.
Toxicology letters 2009;187(2):119-23.
2009: Nadine Aurbek; Horst Thiermann; Florian Eyer; Peter Eyer; Worek Franz
Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.
Toxicology 2009;259(3):133-9.
2009: Nadja M Herkert; Guy Lallement; Didier Clarençon; Horst Thiermann; Worek Franz
Comparison of the oxime-induced reactivation of rhesus monkey, swine and guinea pig erythrocyte acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity.
Toxicology 2009;258(2-3):79-83.
2008: Peter Eyer; Michael Eddleston; Horst Thiermann; Worek Franz; Nick A Buckley
Are we using the right dose? - a tale of mole and gram.
British journal of clinical pharmacology 2008;66(4):451-2.
2008: Georg Reiter; John Mikler; Ira Hill; Kendal Weatherby; Horst Thiermann; Worek Franz
Chromatographic resolution, characterisation and quantification of VX enantiomers in hemolysed swine blood samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;873(1):86-94.
2008: Kai Kehe; K Raithel; Helmut Kreppel; M Jochum; Worek Franz; Horst Thiermann
Inhibition of poly(ADP-ribose) polymerase (PARP) influences the mode of sulfur mustard (SM)-induced cell death in HaCaT cells.
Archives of toxicology 2008;82(7):461-70.
2008: Marc-Michael Blum; Christopher M Timperley; Gareth R Williams; Horst Thiermann; Worek Franz
Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase.
Biochemistry 2008;47(18):5216-24.
2008: Harald John; Worek Franz; Horst Thiermann
LC-MS-based procedures for monitoring of toxic organophosphorus compounds and verification of pesticide and nerve agent poisoning.
Analytical and bioanalytical chemistry 2008;391(1):97-116.
2008: Nadja M Herkert; Saskia Eckert; Peter Eyer; Rudolf Bumm; Georg Weber; Horst Thiermann; Worek Franz
Identical kinetics of human erythrocyte and muscle acetylcholinesterase with respect to carbamate pre-treatment, residual activity upon soman challenge and spontaneous reactivation after withdrawal of the inhibitors.
Toxicology 2008;246(2-3):188-92.
2008: Saskia Eckert; Peter Eyer; Marco Melzer; Horst Thiermann; Worek Franz
Effects of oximes on rate of decarbamylation of human red blood cell AChE measured with two different methods.
Biochemical pharmacology 2008;75(7):1561-6.
2008: Worek Franz; Nadine Aurbek; J Wetherell; P Pearce; T Mann; Horst Thiermann
Inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds: pig versus minipig acetylcholinesterase.
Toxicology 2008;244(1):35-41.
2008: Saskia Eckert; Peter Eyer; Nadja Herkert; Rudolf Bumm; Georg Weber; Horst Thiermann; Worek Franz
Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity.
Biochemical pharmacology 2008;75(3):698-703.
2008: Kai Kehe; Frank Balszuweit; Judith Emmler; Helmut Kreppel; Marianne Jochum; Horst Thiermann
Sulfur mustard research--strategies for the development of improved medical therapy.
Eplasty 2008;8():e32.
2007: Georg Reiter; Marianne Koller; Horst Thiermann; Frédéric Dorandeu; John Mikler; Worek Franz
Development and application of procedures for the highly sensitive quantification of cyclosarin enantiomers in hemolysed swine blood samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;859(1):9-15.
2007: Worek Franz; Nadine Aurbek; Horst Thiermann
Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro.
Journal of applied toxicology : JAT 2007;27(6):582-8.
2007: Horst Thiermann; Kai Kehe; Dirk Steinritz; John Mikler; Ira Hill; Thomas Zilker; Peter Eyer; Worek Franz
Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds.
Arhiv za higijenu rada i toksikologiju 2007;58(3):359-66.
2007: C Reidenbach; Robert H G Schwinger; Dirk Steinritz; Kai Kehe; Horst Thiermann; Theodor Klotz; Frank Sommer; Wilhelm Bloch; Klara Brixius
Nebivolol induces eNOS activation and NO-liberation in murine corpus cavernosum.
Life sciences 2007;80(26):2421-7.
2007: Christian Grasshoff; Berthold Drexler; Harald Hentschke; Horst Thiermann; Bernd Antkowiak
Cholinergic modulation of sevoflurane potency in cortical and spinal networks in vitro.
Anesthesiology 2007;106(6):1147-55.
2007: Worek Franz; Nadine Aurbek; Marianne Koller; Christian Becker; Peter Eyer; Horst Thiermann
Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates.
Biochemical pharmacology 2007;73(11):1807-17.
2007: T Seeger; Worek Franz; Ladislaus Szinicz; Horst Thiermann
Reevaluation of indirect field stimulation technique to demonstrate oxime effectiveness in OP-poisoning in muscles in vitro.
Toxicology 2007;233(1-3):209-13.
2007: Horst Thiermann; Ladislaus Szinicz; Peter Eyer; Norbert Felgenhauer; Thomas Zilker; Worek Franz
Lessons to be learnt from organophosphorus pesticide poisoning for the treatment of nerve agent poisoning.
Toxicology 2007;233(1-3):145-54.
2007: Frédéric Dorandeu; John Mikler; Horst Thiermann; Catherine Tenn; Corey Davidson; Thomas W Sawyer; Guy Lallement; Worek Franz
Swine models in the design of more effective medical countermeasures against organophosphorus poisoning.
Toxicology 2007;233(1-3):128-44.
2007: Christian Grasshoff; Horst Thiermann; Bernd Antkowiak
Anaesthesia in patients suffering from organophosphorus intoxication--interactions between general anaesthetics and acetylcholine in cortical networks in vitro.
Toxicology 2007;233(1-3):214-22.
2007: Peter Eyer; Ladislaus Szinicz; Horst Thiermann; Worek Franz; Thomas Zilker
Testing of antidotes for organophosphorus compounds: experimental procedures and clinical reality.
Toxicology 2007;233(1-3):108-19.
2007: Ladislaus Szinicz; Worek Franz; Horst Thiermann; Kai Kehe; Saskia Eckert; Peter Eyer
Development of antidotes: problems and strategies.
Toxicology 2007;233(1-3):23-30.
2007: A Bartling; Worek Franz; Ladislaus Szinicz; Horst Thiermann
Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase.
Toxicology 2007;233(1-3):166-72.
2007: Nadine Aurbek; Horst Thiermann; Ladislaus Szinicz; Worek Franz
Evaluation of HI 6 treatment after percutaneous VR exposure by use of a kinetic-based dynamic computer model.
Toxicology 2007;233(1-3):173-9.
2007: Worek Franz; Peter Eyer; Ladislaus Szinicz; Horst Thiermann
Simulation of cholinesterase status at different scenarios of nerve agent exposure.
Toxicology 2007;233(1-3):155-65.
2007: Worek Franz; Peter Eyer; Nadine Aurbek; Ladislaus Szinicz; Horst Thiermann
Recent advances in evaluation of oxime efficacy in nerve agent poisoning by in vitro analysis.
Toxicology and applied pharmacology 2007;219(2-3):226-34.
2006: Nadine Aurbek; Horst Thiermann; Ladislaus Szinicz; Peter Eyer; Worek Franz
Application of kinetic-based computer modelling to evaluate the efficacy of HI 6 in percutaneous VX poisoning.
Toxicology 2006;224(1-2):74-80.
2006: Nadine Aurbek; Horst Thiermann; Ladislaus Szinicz; Peter Eyer; Worek Franz
Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase.
Toxicology 2006;224(1-2):91-9.
2005: Worek Franz; Ladislaus Szinicz; Horst Thiermann
Estimation of oxime efficacy in nerve agent poisoning: a kinetic approach.
Chemico-biological interactions 2005;157-158():349-52.
2005: Horst Thiermann; Ladislaus Szinicz; Peter Eyer; Thomas Zilker; Worek Franz
Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning.
Chemico-biological interactions 2005;157-158():345-7.
2005: Worek Franz; Ladislaus Szinicz; Peter Eyer; Horst Thiermann
Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model.
Toxicology and applied pharmacology 2005;209(3):193-202.
2005: A Bartling; Horst Thiermann; Ladislaus Szinicz; Worek Franz
Effect of metoclopramide and ranitidine on the inhibition of human AChE by VX in vitro.
Journal of applied toxicology : JAT 2005;25(6):568-71.
2005: Worek Franz; Marianne Koller; Horst Thiermann; Ladislaus Szinicz
Diagnostic aspects of organophosphate poisoning.
Toxicology 2005;214(3):182-9.
2005: Horst Thiermann; Peter Eyer; Worek Franz; Ladislaus Szinicz
Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon.
Toxicology 2005;214(3):190-7.
2005: Christian Grasshoff; Thomas Gillessen; Erwin Wagner; Horst Thiermann; Ladislaus Szinicz
Ketamine reduces cholinergic modulated GABA release from rat striatal slices.
Toxicology letters 2005;156(3):361-7.
2004: Worek Franz; Horst Thiermann; Ladislaus Szinicz; Peter Eyer
Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes.
Biochemical pharmacology 2004;68(11):2237-48.
2004: Worek Franz; Horst Thiermann; Ladislaus Szinicz
Reactivation and aging kinetics of human acetylcholinesterase inhibited by organophosphonylcholines.
Archives of toxicology 2004;78(4):212-7.
2003: Christian Grasshoff; Thomas Gillessen; Horst Thiermann; Erwin Wagner; Ladislaus Szinicz
The effect of acetylcholinesterase-inhibition on depolarization-induced GABA release from rat striatal slices.
Toxicology 2003;184(2-3):149-56.
2003: Florian Eyer; Veronika Meischner; Daniela Kiderlen; Horst Thiermann; Worek Franz; Michael Haberkorn; Norbert Felgenhauer; Thomas Zilker; Peter Eyer
Human parathion poisoning. A toxicokinetic analysis.
Toxicological reviews 2003;22(3):143-63.
2002: S Krummer; Horst Thiermann; Worek Franz; Peter Eyer
Equipotent cholinesterase reactivation in vitro by the nerve agent antidotes HI 6 dichloride and HI 6 dimethanesulfonate.
Archives of toxicology 2002;76(10):589-95.
2001: Christian Grasshoff; Horst Thiermann; Thomas Gillessen; Thomas Zilker; Ladislaus Szinicz
Internal standard high-performance liquid chromatography method for the determination of obidoxime in urine of organophosphate-poisoned patients.
Journal of chromatography. B, Biomedical sciences and applications 2001;753(2):203-8.
2000: Worek Franz; Peter Eyer; Daniela Kiderlen; Horst Thiermann; Ladislaus Szinicz
Effect of human plasma on the reactivation of sarin-inhibited human erythrocyte acetylcholinesterase.
Archives of toxicology 2000;74(1):21-6.
1999: Horst Thiermann; Ladislaus Szinicz; Florian Eyer; Worek Franz; Peter Eyer; Norbert Felgenhauer; Thomas Zilker
Modern strategies in therapy of organophosphate poisoning.
Toxicology letters 1999;107(1-3):233-9.
1997: Horst Thiermann; U Mast; R Klimmek; Peter Eyer; A Hibler; Rudolf Pfab; Norbert Felgenhauer; Thomas Zilker
Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients.
Human & experimental toxicology 1997;16(8):473-80.
1997: Worek Franz; M Bäcker; Horst Thiermann; Ladislaus Szinicz; U Mast; R Klimmek; Peter Eyer
Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning.
Human & experimental toxicology 1997;16(8):466-72.
1997: Thomas Zilker; Norbert Felgenhauer; A Hibler; Rudolf Pfab; Horst Thiermann; Worek Franz; Peter Eyer
Factors influencing the efficacy of obidoxime in organophosphate pesticides poisoning.
Przegla̧d lekarski 1997;54(10):662-4.
1996: Horst Thiermann; M Radtke; U Spöhrer; R Klimmek; Peter Eyer
Pharmacokinetics of atropine in dogs after i.m. injection with newly developed dry/wet combination autoinjectors containing HI 6 or HLö 7.
Archives of toxicology 1996;70(5):293-9.
1994: U Spöhrer; Horst Thiermann; R Klimmek; Peter Eyer
Pharmacokinetics of the oximes HI 6 and HLö 7 in dogs after i.m. injection with newly developed dry/wet autoinjectors.
Archives of toxicology 1994;68(8):480-9.
1993: H Kreppel; U Paepcke; Horst Thiermann; Ladislaus Szinicz; Franz-Xaver Reichl; P K Singh; M M Jones
Therapeutic efficacy of new dimercaptosuccinic acid (DMSA) analogues in acute arsenic trioxide poisoning in mice.
Archives of toxicology 1993;67(8):580-5.