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Rajesh Thimmulappa

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Rajesh K Thimmulappa; Joseph L Witztum; Xing Gang; Jung-Hyun Kim; Thomas E Sussan; Shyam Biswal
Oxidized phospholipids impair pulmonary antibacterial defenses: evidence in mice exposed to cigarette smoke.
Shyam Biswal; Rajesh K Thimmulappa; Christopher J Harvey
Experimental therapeutics of Nrf2 as a target for prevention of bacterial exacerbations in COPD.
SARVESH KUMAR; Vineet Kumar; Yogesh Kumar; Shashwat Malhotra; Sanjay V Malhotra; Mukesh K Pandey; Shyam Biswal; Anthony L DePass; Balaram Ghosh; Rajni Jain; Amit Kumar; Ashok K Prasad; Chandra Shekhar Reddy L; Sunil K Sharma; Brajendra K Singh; Rajesh K Thimmulappa; Erik Van Der Eycken; Virinder S Parmar
Arylalkyl ketones, benzophenones, desoxybenzoins and chalcones inhibit TNF-α induced expression of ICAM-1: structure-activity analysis.

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All Publications

2012: Rajesh K Thimmulappa; Joseph L Witztum; Xing Gang; Jung-Hyun Kim; Thomas E Sussan; Shyam Biswal
Oxidized phospholipids impair pulmonary antibacterial defenses: evidence in mice exposed to cigarette smoke.
Biochemical and biophysical research communications 2012;426(2):253-9.
2012: Shyam Biswal; Rajesh K Thimmulappa; Christopher J Harvey
Experimental therapeutics of Nrf2 as a target for prevention of bacterial exacerbations in COPD.
Proceedings of the American Thoracic Society 2012;9(2):47-51.
2012: SARVESH KUMAR; Vineet Kumar; Yogesh Kumar; Shashwat Malhotra; Sanjay V Malhotra; Mukesh K Pandey; Shyam Biswal; Anthony L DePass; Balaram Ghosh; Rajni Jain; Amit Kumar; Ashok K Prasad; Chandra Shekhar Reddy L; Sunil K Sharma; Brajendra K Singh; Rajesh K Thimmulappa; Erik Van Der Eycken; Virinder S Parmar
Arylalkyl ketones, benzophenones, desoxybenzoins and chalcones inhibit TNF-α induced expression of ICAM-1: structure-activity analysis.
Archiv der Pharmazie 2012;345(5):368-77.
2012: Ponvijay Kombairaju; JINFANG MA; Anju Singh; Rajesh K Thimmulappa; Shengbin G Yan; Edward Gabrielson; Shyam Biswal
Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer.
Journal of carcinogenesis 2012;11():8.
2012: Kassim Traore; Shyam Biswal; Rajesh K Thimmulappa; Barry R Zirkin; Michael A Trush
Upregulation of TLR1, TLR2, TLR4, and IRAK-2 Expression During ML-1 Cell Differentiation to Macrophages: Role in the Potentiation of Cellular Responses to LPS and LTA.
ISRN oncology 2012;2012():641246.
2011: Deepti Malhotra; Nicolas Mercado; Rajesh K Thimmulappa; Robert Wise; DAVID FELLER-KOPMAN; Kazuhiro Ito; Ponvijay Kombairaju; SARVESH KUMAR; JINFANG MA; Peter Barnes; Shyam Biswal
Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients.
The Journal of clinical investigation 2011;121(11):4289-302.
2011: SARVESH KUMAR; Shashwat Malhotra; Carl E Olsen; Virinder S Parmar; Ashok K Prasad; Brajendra K Singh; Rajesh K Thimmulappa; Erik Van Der Eycken; Pragya Arya; Shyam Biswal; Anthony L DePass; Balaram Ghosh
Novel natural product-based cinnamates and their thio and thiono analogs as potent inhibitors of cell adhesion molecules on human endothelial cells.
European journal of medicinal chemistry 2011;46(11):5498-511.
2011: Xiaoni Kong; SEKHAR POTHIREDDY; Florin Craciun; Ponvijay Kombairaju; Rajesh K Thimmulappa; Daniel Remick; Anju Singh; Christopher Harvey; Shyam Biswal
Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis.
American journal of respiratory and critical care medicine 2011;184(8):928-38.
2011: Vineet Kumar; Shyam Biswal; Mohammad Hassan; Amit Kumar; SARVESH KUMAR; Virinder S Parmar; Sunil K Sharma; Rajesh K Thimmulappa; Hailong Wu; Sanjay V Malhotra
Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.
Journal of medicinal chemistry 2011;54(12):4147-59.
2011: Mukesh K Pandey; SARVESH KUMAR; Rajesh K Thimmulappa; Virinder S Parmar; Shyam Biswal; Arthur C Watterson
Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2011;43(1-2):16-24.
2011: Christopher J Harvey; Rajesh K Thimmulappa; Sanjay Sethi; Xiaoni Kong; Lonny Brett Yarmus; Robert H Brown; DAVID FELLER-KOPMAN; Robert Wise; Shyam Biswal
Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model.
Science translational medicine 2011;3(78):78ra32.
2011: Nicolas Mercado; Rajesh K Thimmulappa; Catherine M R Thomas; Peter S Fenwick; Kirandeep K Chana; Louise E Donnelly; Shyam Biswal; Kazuhiro Ito; Peter J Barnes
Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress.
Biochemical and biophysical research communications 2011;406(2):292-8.
2010: Xiaoni Kong; Rajesh K Thimmulappa; Ponvijay Kombairaju; Shyam Biswal
NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(1):569-77.
2010: Toshinori Yoshida; Igor Mett; Anil K Bhunia; Joel Bowman; Mario Perez; Li Zhang; Aneta Gandjeva; Lijie Zhen; Ugonma Chukwueke; Tianzhi Mao; Amy Richter; Emile Brown; Hagit Ashush; Natalie Notkin; Anna Gelfand; Rajesh K Thimmulappa; Tirumalai Rangasamy; Thomas Sussan; Gregory Cosgrove; Majd Mouded; Steven D Shapiro; Irina Petrache; Shyam Biswal; Elena Feinstein; Rubin M Tuder
Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema.
Nature medicine 2010;16(7):767-73.
2009: Deepti Malhotra; Rajesh K Thimmulappa; Neeraj Vij; Ana Navas-Acien; Thomas Sussan; Salim Merali; Li Zhang; Steven G Kelsen; Allen C Myers; Robert Wise; Rubin M Tuder; Shyam Biswal
Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity.
American journal of respiratory and critical care medicine 2009;180(12):1196-207.
2009: Norihiro Nagai; Rajesh K Thimmulappa; Marisol Cano; Masashi Fujihara; Kanako Izumi-Nagai; Xiaoni Kong; Michael B. Sporn; Thomas W Kensler; Shyam Biswal; James T Handa
Nrf2 is a critical modulator of the innate immune response in a model of uveitis.
Free radical biology & medicine 2009;47(3):300-6.
2009: Sharon A McGrath-Morrow; Thomas Lauer; Min Yee; Enid R Neptune; Megan Podowski; Rajesh K Thimmulappa; Michael O'Reilly; Shyam Biswal
Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia.
American journal of physiology. Lung cellular and molecular physiology 2009;296(4):L565-73.
2009: C J Harvey; Rajesh K Thimmulappa; Anju Singh; D J Blake; G Ling; Nobunao Wakabayashi; J Fujii; Allen C Myers; Shyam Biswal
Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress.
Free radical biology & medicine 2009;46(4):443-53.
2008: Anju Singh; Swetlana Boldin-Adamsky; Rajesh K Thimmulappa; Srikanta Kumar Rath; Hagit Ashush; Jonathan Coulter; Amanda Blackford; Steven Goodman; Fred Bunz; WALTER WATSON; Edward Gabrielson; Elena Feinstein; Shyam Biswal
RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy.
Cancer research 2008;68(19):7975-84.
2008: Deepti Malhotra; Rajesh K Thimmulappa; Ana Navas-Acien; Andrew Sandford; Mark Elliott; Anju Singh; Linan Chen; Xiaoxi Zhuang; James Hogg; Peter Pare; Rubin M Tuder; Shyam Biswal
Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1.
American journal of respiratory and critical care medicine 2008;178(6):592-604.
2008: Rajesh K Thimmulappa; Tirumalai Rangasamy; Jawed Alam; Shyam Biswal
Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA adducts in lungs.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2008;4(5):473-81.
2008: Kassim Traore; Rajni Sharma; Rajesh K Thimmulappa; WALTER WATSON; Shyam Biswal; Michael A Trush
Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: role in signaling TPA-induced growth arrest in ML-1 cells.
Journal of cellular physiology 2008;216(1):276-85.
2008: Thomas E Sussan; Jonathan Jun; Rajesh K Thimmulappa; Djahida Bedja; Maria Antero; Kathleen L Gabrielson; Vsevolod Y Polotsky; Shyam Biswal
Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice.
PloS one 2008;3(11):e3791.
2007: Vikas Misra; Hannah Lee; Anju Singh; Kewu Huang; Rajesh K Thimmulappa; Wayne Mitzner; Shyam Biswal; Clarke G Tankersley
Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes.
Physiological genomics 2007;31(3):429-40.
2007: Rajesh K Thimmulappa; RALPH FUCHS; Deepti Malhotra; Catherine Scollick; Kassim Traore; Jay H Bream; Michael A Trush; Karen T Liby; Michael B. Sporn; Thomas W Kensler; Shyam Biswal
Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.
Antioxidants & redox signaling 2007;9(11):1963-70.
2007: Jian Wang; Jocelyn Fields; Chunying Zhao; John Langer; Rajesh K Thimmulappa; Thomas W Kensler; Masayuki Yamamoto; Shyam Biswal; Sylvain Dore
Role of Nrf2 in protection against intracerebral hemorrhage injury in mice.
Free radical biology & medicine 2007;43(3):408-14.
2007: Zahoor Shah; Rung-chi Li; Rajesh K Thimmulappa; Thomas W Kensler; Masayuki Yamamoto; Shyam Biswal; Sylvain Dore
Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury.
Neuroscience 2007;147(1):53-9.
2006: Rajesh K Thimmulappa; Catherine Scollick; Kassim Traore; Melinda Yates; Michael A Trush; Karen T Liby; Michael B. Sporn; Masayuki Yamamoto; Thomas W Kensler; Shyam Biswal
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide.
Biochemical and biophysical research communications 2006;351(4):883-9.
2006: Anju Singh; Tirumalai Rangasamy; Rajesh K Thimmulappa; Hannah Lee; William O Osburn; Regina Brigelius-Flohé; Thomas W Kensler; Masayuki Yamamoto; Shyam Biswal
Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2.
American journal of respiratory cell and molecular biology 2006;35(6):639-50.
2006: Anju Singh; Vikas Misra; Rajesh K Thimmulappa; Hannah Lee; Stephen Ames; Mohammad Hoque; James G Herman; Stephen B Baylin; David Sidransky; Edward Gabrielson; Malcolm V Brock; Shyam Biswal
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.
PLoS medicine 2006;3(10):e420.
2006: Rajesh K Thimmulappa; Hannah Lee; Tirumalai Rangasamy; SEKHAR POTHIREDDY; Masayuki Yamamoto; Thomas W Kensler; Shyam Biswal
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.
The Journal of clinical investigation 2006;116(4):984-95.
2004: Tirumalai Rangasamy; Chung Y Cho; Rajesh K Thimmulappa; Lijie Zhen; Sorachai Srisuma; Thomas W Kensler; Masayuki Yamamoto; Irina Petrache; Rubin M Tuder; Shyam Biswal
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice.
The Journal of clinical investigation 2004;114(9):1248-59.
2002: Rajesh K Thimmulappa; Kim H Mai; Sorachai Srisuma; Thomas W Kensler; Masayuki Yamamoto; Shyam Biswal
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.
Cancer research 2002;62(18):5196-203.