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Gopal Thinakaran

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Mahua Maulik; Gopal Thinakaran; Satyabrata Kar
Alterations in gene expression in mutant amyloid precursor protein transgenic mice lacking Niemann-Pick type C1 protein.
Christian Haass; Christoph Kaether; Gopal Thinakaran; Sangram Sisodia
Trafficking and proteolytic processing of APP.
Carole Deyts; Denis J Dupré; Yumiko M Shepherd; Gopal Thinakaran; Kulandaivelu S Vetrivel; Shibandri Das; Angèle T Parent
Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain.

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All Publications

2013: Mahua Maulik; Gopal Thinakaran; Satyabrata Kar
Alterations in gene expression in mutant amyloid precursor protein transgenic mice lacking Niemann-Pick type C1 protein.
PloS one 2013;8(1):e54605.
2012: Christian Haass; Christoph Kaether; Gopal Thinakaran; Sangram Sisodia
Trafficking and proteolytic processing of APP.
Cold Spring Harbor perspectives in medicine 2012;2(5):a006270.
2012: Carole Deyts; Denis J Dupré; Yumiko M Shepherd; Gopal Thinakaran; Kulandaivelu S Vetrivel; Shibandri Das; Angèle T Parent
Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(5):1714-29.
2012: Naoyuki Sato; Mitsuru Shinohara; Motoko Shinohara-Noma; Masatoshi Takeda; Shuko Takeda; Gopal Thinakaran; Akio Fukumori; Hizuki Hamada; Mari Mori-Ueda; Masayasu Okochi; Hiromi Rakugi; Ryuichi Morishita
Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs.
PloS one 2012;7(11):e48551.
2011: William Zeiger; Mitchel L Villereal; Daisuke Ito; Masatsugu Oh-hora; Carol Swetlik; Gopal Thinakaran
Stanniocalcin 2 is a negative modulator of store-operated calcium entry.
Molecular and cellular biology 2011;31(18):3710-22.
2011: Kulandaivelu S Vetrivel; Steven L Wagner; Arghya Barman; Ying Chen; Phuong D Nguyen; Rajeev Prabhakar; Gopal Thinakaran
Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.
The Journal of biological chemistry 2011;286(29):26166-77.
2011: Ping Gong; Satyabrata Kar; Angèle T Parent; Jelita Roseman; Vytautas P Bindokas; Celia G Fernandez; Kulandaivelu S Vetrivel; Lois A Zitzow; Gopal Thinakaran
Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice.
Molecular neurodegeneration 2011;6():87.
2010: Ping Gong; Kulandaivelu S Vetrivel; Phuong D Nguyen; Xavier Meckler; Haipeng Cheng; Maria Z Kounnas; Steven L Wagner; Angèle T Parent; Gopal Thinakaran
Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.
The Journal of biological chemistry 2010;285(49):38042-52.
2010: Xavier Meckler; Jelita Roseman; Pritam Das; Haipeng Cheng; Susan Pei; Marcia Keat; Breanne Kassarjian; todd golde; Angèle T Parent; Gopal Thinakaran
Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(48):16160-9.
2010: A Kodam; M Maulik; K Peake; A Amritraj; Kulandaivelu S Vetrivel; Gopal Thinakaran; Jean E Vance; Satyabrata Kar
Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann-Pick type C1-deficient mouse brains.
Glia 2010;58(11):1267-81.
2010: Kulandaivelu S Vetrivel; Gopal Thinakaran
Membrane rafts in Alzheimer's disease beta-amyloid production.
Biochimica et biophysica acta 2010;1801(8):860-7.
2010: Angèle T Parent; Gopal Thinakaran
Modeling presenilin-dependent familial Alzheimer's disease: emphasis on presenilin substrate-mediated signaling and synaptic function.
International journal of Alzheimer's disease 2010;2010():.
2009: Adam B White; Maria I Givogri; Aurora Lopez-Rosas; Hongmei Cao; Richard B Van Breemen; Gopal Thinakaran; Ernesto R Bongarzone
Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(19):6068-77.
2009: Kulandaivelu S Vetrivel; Xavier Meckler; Ying Chen; Phuong D Nguyen; Nabil G Seidah; Robert Vassar; Philip C Wong; Masaki Fukata; Maria Z Kounnas; Gopal Thinakaran
Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.
The Journal of biological chemistry 2009;284(6):3793-803.
2009: Haipeng Cheng; Kulandaivelu S Vetrivel; Renaldo C Drisdel; Xavier Meckler; Ping Gong; Jae Yoon Leem; Tong Li; Meghan Carter; Ying Chen; Phuong Nguyen; Takeshi Iwatsubo; Taisuke Tomita; Philip C Wong; William N Green; Maria Z Kounnas; Gopal Thinakaran
S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.
The Journal of biological chemistry 2009;284(3):1373-84.
2008: Gopal Thinakaran; Edward H Koo
Amyloid precursor protein trafficking, processing, and function.
The Journal of biological chemistry 2008;283(44):29615-9.
2008: Kenneth E Neet; Gopal Thinakaran
Thematic minireview series on the molecular basis of Alzheimer disease.
The Journal of biological chemistry 2008;283(44):29613-4.
2008: Kulandaivelu S Vetrivel; Anitha Kodam; Ping Gong; Ying Chen; Angèle T Parent; Satyabrata Kar; Gopal Thinakaran
Localization and regional distribution of p23/TMP21 in the brain.
Neurobiology of disease 2008;32(1):37-49.
2008: Kulandaivelu S Vetrivel; Xulun Zhang; Xavier Meckler; Haipeng Cheng; Sungho Lee; Ping Gong; Kryslaine O Lopes; Ying Chen; Nobuhisa Iwata; Ke-Jie Yin; Jin-Moo Lee; Angèle T Parent; Takaomi C Saido; Yueming Li; Sangram S Sisodia; Gopal Thinakaran
Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta.
The Journal of biological chemistry 2008;283(28):19489-98.
2008: A Kodam; Kulandaivelu S Vetrivel; Gopal Thinakaran; Satyabrata Kar
Cellular distribution of gamma-secretase subunit nicastrin in the developing and adult rat brains.
Neurobiology of aging 2008;29(5):724-38.
2008: Natalie Y Barnes; Jun Shi; Hiroshi Yajima; Gopal Thinakaran; Angèle T Parent
Steady-state increase of cAMP-response element binding protein, Rac, and PAK signaling in presenilin-deficient neurons.
Journal of neurochemistry 2008;104(6):1637-48.
2007: Jinoh Kim; Bertrand Kleizen; Regina Choy; Gopal Thinakaran; Sangram S Sisodia; Randy Schekman
Biogenesis of gamma-secretase early in the secretory pathway.
The Journal of cell biology 2007;179(5):951-63.
2007: Haipeng Cheng; Kulandaivelu S Vetrivel; Ping Gong; Xavier Meckler; Angèle T Parent; Gopal Thinakaran
Mechanisms of disease: new therapeutic strategies for Alzheimer's disease--targeting APP processing in lipid rafts.
Nature clinical practice. Neurology 2007;3(7):374-82.
2007: Kulandaivelu S Vetrivel; Ping Gong; James W Bowen; Haipeng Cheng; Ying Chen; Meghan Carter; Phuong D Nguyen; Lisa Placanica; Felix T Wieland; Yueming Li; Maria Z Kounnas; Gopal Thinakaran
Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism.
Molecular neurodegeneration 2007;2():4.
2006: Gopal Thinakaran; Sangram S Sisodia
Presenilins and Alzheimer disease: the calcium conspiracy.
Nature neuroscience 2006;9(11):1354-5.
2006: Kulandaivelu S Vetrivel; Gopal Thinakaran
Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments.
Neurology 2006;66(2 Suppl 1):S69-73.
2006: Kulandaivelu S Vetrivel; Yun-Wu Zhang; Huaxi Xu; Gopal Thinakaran
Pathological and physiological functions of presenilins.
Molecular neurodegeneration 2006;1():4.
2005: Isabelle Jutras; annie laplante; Jonathan Boulais; Sylvain Brunet; Gopal Thinakaran; Michel Desjardins
Gamma-secretase is a functional component of phagosomes.
The Journal of biological chemistry 2005;280(43):36310-7.
2005: Kulandaivelu S Vetrivel; Haipeng Cheng; Seong-Hun Kim; Ying Chen; Natalie Y Barnes; Angèle T Parent; Sangram S Sisodia; Gopal Thinakaran
Spatial segregation of gamma-secretase and substrates in distinct membrane domains.
The Journal of biological chemistry 2005;280(27):25892-900.
2005: Yun-Wu Zhang; Wen-jie Luo; Hong Wang; Ping Lin; Kulandaivelu S Vetrivel; Fang Liao; Feng Li; Philip C Wong; Marilyn G Farquhar; Gopal Thinakaran; Huaxi Xu
Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.
The Journal of biological chemistry 2005;280(17):17020-6.
2005: Angèle T Parent; Natalie Y Barnes; Yoshihito Taniguchi; Gopal Thinakaran; Sangram S Sisodia
Presenilin attenuates receptor-mediated signaling and synaptic function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(6):1540-9.
2004: Daisuke Ito; John R Walker; Charlie S Thompson; Isabella Moroz; William Lin; Margaret L Veselits; Antoine M Hakim; Allen Fienberg; Gopal Thinakaran
Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties.
Molecular and cellular biology 2004;24(21):9456-69.
2004: Kulandaivelu S Vetrivel; Haipeng Cheng; William Lin; Takashi Sakurai; Tong Li; Nobuyuki Nukina; Philip C Wong; Huaxi Xu; Gopal Thinakaran
Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.
The Journal of biological chemistry 2004;279(43):44945-54.
2004: Gopal Thinakaran; Angèle T Parent
Identification of the role of presenilins beyond Alzheimer's disease.
Pharmacological research : the official journal of the Italian Pharmacological Society 2004;50(4):411-8.
2004: Hong Wang; Wen-jie Luo; Yun-Wu Zhang; Yueming Li; Gopal Thinakaran; Paul Greengard; Huaxi Xu
Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components.
The Journal of biological chemistry 2004;279(39):40560-6.
2003: Nobumasa Takasugi; Taisuke Tomita; Ikuo Hayashi; Makiko Tsuruoka; Manabu Niimura; Yasuko Takahashi; Gopal Thinakaran; Takeshi Iwatsubo
The role of presenilin cofactors in the gamma-secretase complex.
Nature 2003;422(6930):438-41.
2003: Wen-jie Luo; Hong Wang; Hongqiao Li; Benny S Kim; Sanjiv Shah; Hahn-Jun Lee; Gopal Thinakaran; TAE-WAN KIM; Gang G. Yu; Huaxi Xu
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.
The Journal of biological chemistry 2003;278(10):7850-4.
2003: Dongming Cai; Jae Yoon Leem; Jeffrey P Greenfield; Pei Wang; Benny S Kim; Runsheng Wang; Kryslaine O Lopes; Seong-Hun Kim; Hui Zheng; Paul Greengard; Sangram S Sisodia; Gopal Thinakaran; Huaxi Xu
Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein.
The Journal of biological chemistry 2003;278(5):3446-54.
2003: Gopal Thinakaran; James W Bowen; Daisuke Ito; Jae Yoon Leem; Margaret L Veselits; Naoyuki Sato
Investigation of unfolded-protein response in cells expressing familial Alzheimer's disease-linked presenilin variants.
Methods in molecular biology (Clifton, N.J.) 2003;232():203-16.
2002: Jae Yoon Leem; Carlos A Saura; Claus U Pietrzik; John C Christianson; Christian P Wanamaker; LaShaunda T King; Margaret L Veselits; Taisuke Tomita; Laura Gasparini; Takeshi Iwatsubo; Huaxi Xu; William N Green; Edward H Koo; Gopal Thinakaran
A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface.
Neurobiology of disease 2002;11(1):64-82.
2002: Jae Yoon Leem; Shrijay Vijayan; Ping Han; Dongming Cai; Michael Machura; Kryslaine O Lopes; Margaret L Veselits; Huaxi Xu; Gopal Thinakaran
Presenilin 1 is required for maturation and cell surface accumulation of nicastrin.
The Journal of biological chemistry 2002;277(21):19236-40.
2002: Seong-Hun Kim; John W M Creemers; Su Chu; Gopal Thinakaran; Sangram S Sisodia
Proteolytic processing of familial British dementia-associated BRI variants: evidence for enhanced intracellular accumulation of amyloidogenic peptides.
The Journal of biological chemistry 2002;277(3):1872-7.
2001: Robert Siman; Dorothy G Flood; Gopal Thinakaran; Robert W Neumar
Endoplasmic reticulum stress-induced cysteine protease activation in cortical neurons: effect of an Alzheimer's disease-linked presenilin-1 knock-in mutation.
The Journal of biological chemistry 2001;276(48):44736-43.
2001: Seong-Hun Kim; Jae Yoon Leem; James J Lah; Hilda H Slunt; Allan Levey; Gopal Thinakaran; Sangram S Sisodia
Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein.
The Journal of biological chemistry 2001;276(46):43343-50.
2001: Gopal Thinakaran
Metabolism of presenilins.
Journal of molecular neuroscience : MN 2001;17(2):183-92.
2000: N Sato; F Urano; J Yoon Leem; Seong-Hun Kim; M Li; D Donoviel; A Bernstein; A S Lee; D Ron; Margaret L Veselits; Sangram S Sisodia; Gopal Thinakaran
Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.
Nature cell biology 2000;2(12):863-70.
2000: Masaaki Takahashi; Sylvain Dore; Christopher D Ferris; Taisuke Tomita; Akira Sawa; H Wolosker; David R Borchelt; Takeshi Iwatsubo; Seong-Hun Kim; Gopal Thinakaran; Sangram S Sisodia; Solomon H Snyder
Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease.
Neuron 2000;28(2):461-73.
2000: Carlos A Saura; Taisuke Tomita; Salvador Soriano; M Takahashi; Jae Yoon Leem; T Honda; Edward H Koo; Takeshi Iwatsubo; Gopal Thinakaran
The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.
The Journal of biological chemistry 2000;275(22):17136-42.
2000: Seong-Hun Kim; James J Lah; Gopal Thinakaran; Allan Levey; Sangram S Sisodia
Subcellular localization of presenilins: association with a unique membrane pool in cultured cells.
Neurobiology of disease 2000;7(2):99-117.
2000: Gopal Thinakaran; A Doan
Determining the transmembrane topology of the presenilins.
Methods in molecular medicine 2000;32():283-96.
2000: Seong-Hun Kim; Rong Wang; David J Gordon; J Bass; Donald F Steiner; Gopal Thinakaran; David G Lynn; Stephen C Meredith; Sangram S Sisodia
Familial British dementia: expression and metabolism of BRI.
Annals of the New York Academy of Sciences 2000;920():93-9.
1999: Bridget E Berechid; Gopal Thinakaran; Philip C Wong; Sangram S Sisodia; Jeffrey S Nye
Lack of requirement for presenilin1 in Notch1 signaling.
Current biology : CB 1999;9(24):1493-6.
1999: Gopal Thinakaran
The role of presenilins in Alzheimer's disease.
The Journal of clinical investigation 1999;104(10):1321-7.
1999: Seong-Hun Kim; Rong Wang; David J Gordon; J Bass; Donald F Steiner; David G Lynn; Gopal Thinakaran; Stephen C Meredith; Sangram S Sisodia
Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia.
Nature neuroscience 1999;2(11):984-8.
1999: X F Li; Gopal Thinakaran; Sangram S Sisodia; Fu-Shin X Yu
Amyloid precursor-like protein 2 promotes cell migration toward fibronectin and collagen IV.
The Journal of biological chemistry 1999;274(38):27249-56.
1999: Sangram S Sisodia; Seong-Hun Kim; Gopal Thinakaran
Function and dysfunction of the presenilins.
American journal of human genetics 1999;65(1):7-12.
1999: Carlos A Saura; Taisuke Tomita; F Davenport; CL Harris; Takeshi Iwatsubo; Gopal Thinakaran
Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing.
The Journal of biological chemistry 1999;274(20):13818-23.
1999: Jeffrey P Greenfield; J Tsai; Gunnar K Gouras; B Hai; Gopal Thinakaran; F Checler; Sangram S Sisodia; Paul Greengard; Huaxi Xu
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):742-7.
1998: Joseph Buxbaum; Gopal Thinakaran; Vassilis E Koliatsos; J O'Callahan; Hilda H Slunt; Donald L Price; Sangram S Sisodia
Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(23):9629-37.
1998: S Naruse; Gopal Thinakaran; JJ Luo; John W Kusiak; Taisuke Tomita; Takeshi Iwatsubo; X Qian; David D Ginty; Donald L Price; David R Borchelt; Philip C Wong; Sangram S Sisodia
Effects of PS1 deficiency on membrane protein trafficking in neurons.
Neuron 1998;21(5):1213-21.
1998: MJ McNamara; C T Ruff; Wilma Wasco; Rudolph E Tanzi; Gopal Thinakaran; Bradley T Hyman
Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains.
Brain research 1998;804(1):45-51.
1998: David R Borchelt; Philip C Wong; Mark W Becher; CARLOS PARDO-VILLAMIZAR; Michael K Lee; Z S Xu; Gopal Thinakaran; Nancy A Jenkins; Neal G Copeland; Sangram S Sisodia; Don W Cleveland; Donald L Price; Paul N Hoffman
Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice.
Neurobiology of disease 1998;5(1):27-35.
1998: Alvin W Lyckman; AM Confaloni; Gopal Thinakaran; Sangram S Sisodia; KL Moya
Post-translational processing and turnover kinetics of presynaptically targeted amyloid precursor superfamily proteins in the central nervous system.
The Journal of biological chemistry 1998;273(18):11100-6.
1998: Gopal Thinakaran; J B Regard; Christopher MLS Bouton; CL Harris; Donald L Price; David R Borchelt; Sangram S Sisodia
Stable association of presenilin derivatives and absence of presenilin interactions with APP.
Neurobiology of disease 1998;4(6):438-53.
1998: Huaxi Xu; Gunnar K Gouras; Jeffrey P Greenfield; B Vincent; J Naslund; L Mazzarelli; G Fried; J N Jovanovic; M Seeger; Norman Richard Relkin; F Liao; F Checler; Joseph Buxbaum; Brian T Chait; Gopal Thinakaran; Sangram S Sisodia; Runsheng Wang; Paul Greengard; Sam Gandy
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Nature medicine 1998;4(4):447-51.
1998: J Guo; Gopal Thinakaran; Y Guo; Sangram S Sisodia; Fu-Shin X Yu
A role for amyloid precursor-like protein 2 in corneal epithelial wound healing.
Investigative ophthalmology & visual science 1998;39(2):292-300.
1998: Philip C Wong; David R Borchelt; Michael K Lee; CARLOS PARDO-VILLAMIZAR; Gopal Thinakaran; Lee J Martin; Sangram S Sisodia; Donald L Price
Familial amyotrophic lateral sclerosis and Alzheimer's disease. Transgenic models.
Advances in experimental medicine and biology 1998;446():145-59.
1997: Gopal Thinakaran; CL Harris; TAMARA RATOVITSKI; F Davenport; Hilda H Slunt; Donald L Price; David R Borchelt; Sangram S Sisodia
Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.
The Journal of biological chemistry 1997;272(45):28415-22.
1997: C S von Koch; Hui Zheng; H Chen; Myrna E Trumbauer; Gopal Thinakaran; Lex H T Van Der Ploeg; Donald L Price; Sangram S Sisodia
Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice.
Neurobiology of aging 1997;18(6):661-9.
1997: TAMARA RATOVITSKI; Hilda H Slunt; Gopal Thinakaran; Donald L Price; Sangram S Sisodia; David R Borchelt
Endoproteolytic processing and stabilization of wild-type and mutant presenilin.
The Journal of biological chemistry 1997;272(39):24536-41.
1997: Donald L Price; Philip C Wong; David R Borchelt; CARLOS PARDO-VILLAMIZAR; Gopal Thinakaran; AP Doan; Michael K Lee; Lee J Martin; Sangram S Sisodia
Amyotrophic lateral sclerosis and Alzheimer disease. Lessons from model systems.
Revue neurologique 1997;153(8-9):484-95.
1997: Michael K Lee; David R Borchelt; G Kim; Gopal Thinakaran; Hilda H Slunt; TAMARA RATOVITSKI; Lee J Martin; A Kittur; Sam Gandy; Allan Levey; Nancy Jenkins; Neal G Copeland; Donald L Price; Sangram S Sisodia
Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.
Nature medicine 1997;3(7):756-60.
1997: M Seeger; C Nordstedt; Suzana Petanceska; Dora M. Kovacs; Gunnar K Gouras; S Hahne; Paul E Fraser; L Levesque; Andrew J Czernik; Peter St George-Hyslop; Sangram S Sisodia; Gopal Thinakaran; Rudolph E Tanzi; Paul Greengard; Sam Gandy
Evidence for phosphorylation and oligomeric assembly of presenilin 1.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5090-4.
1997: L Hendriks; Gopal Thinakaran; C L Harris; Chris De Jonghe; Jean-Jacques Martin; Sangram S Sisodia; Christine Van Broeckhoven
Processing of presenilin 1 in brains of patients with Alzheimer's disease and controls.
Neuroreport 1997;8(7):1717-21.
1997: Huaxi Xu; D Sweeney; Rong Wang; Gopal Thinakaran; Amy Lo; Sangram S Sisodia; Paul Greengard; Sam Gandy
Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3748-52.
1997: Jochen Walter; Anja Capell; A Y Hung; H Langen; M Schnölzer; Gopal Thinakaran; Sangram S Sisodia; Dennis J Selkoe; Christian Haass
Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations.
The Journal of biological chemistry 1997;272(3):1896-903.
1997: F Yehiely; P Bamborough; M Da Costa; B J Perry; Gopal Thinakaran; Fred Cohen; G A Carlson; Stanley B Prusiner
Identification of candidate proteins binding to prion protein.
Neurobiology of disease 1997;3(4):339-55.
1996: D Levitan; T G Doyle; D Brousseau; Michael K Lee; Gopal Thinakaran; Hilda H Slunt; Sangram S Sisodia; Iva Greenwald
Assessment of normal and mutant human presenilin function in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14940-4.
1996: Michael E Calhoun; Mathias Jucker; Lee J Martin; Gopal Thinakaran; Donald L Price; Peter R Mouton
Comparative evaluation of synaptophysin-based methods for quantification of synapses.
Journal of neurocytology 1996;25(12):821-8.
1996: Michael K Lee; Hilda H Slunt; Lee J Martin; Gopal Thinakaran; G Kim; Sam Gandy; M Seeger; Edward H Koo; Donald L Price; Sangram S Sisodia
Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(23):7513-25.
1996: AP Doan; Gopal Thinakaran; David R Borchelt; Hilda H Slunt; T Ratovitsky; M Podlisny; Dennis J Selkoe; M Seeger; Sam Gandy; Donald L Price; Sangram S Sisodia
Protein topology of presenilin 1.
Neuron 1996;17(5):1023-30.
1996: David R Borchelt; Gopal Thinakaran; Christopher B Eckman; Michael K Lee; F Davenport; T Ratovitsky; CM Prada; G Kim; S Seekins; Debra Yager; Hilda H Slunt; Rong Wang; M Seeger; Allan Levey; Sam Gandy; Neal G Copeland; Nancy A Jenkins; Donald L Price; Steven G Younkin; Sangram S Sisodia
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.
Neuron 1996;17(5):1005-13.
1996: Barbara J Crain; W Hu; C I Sze; Hilda H Slunt; Edward H Koo; Donald L Price; Gopal Thinakaran; Sangram S Sisodia
Expression and distribution of amyloid precursor protein-like protein-2 in Alzheimer's disease and in normal brain.
The American journal of pathology 1996;149(4):1087-95.
1996: Gopal Thinakaran; David R Borchelt; Michael K Lee; Hilda H Slunt; L Spitzer; G Kim; T Ratovitsky; F Davenport; C Nordstedt; M Seeger; John Hardy; Allan Levey; Sam Gandy; Nancy A Jenkins; Neal G Copeland; Donald L Price; Sangram S Sisodia
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Neuron 1996;17(1):181-90.
1996: Gopal Thinakaran; David B Teplow; R Siman; Barry D Greenberg; Sangram S Sisodia
Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.
The Journal of biological chemistry 1996;271(16):9390-7.
1996: Sangram S Sisodia; Gopal Thinakaran; Hilda H Slunt; C A Kitt; C S Von Koch; Randall R Reed; H Zheng; Donald L Price
Studies on the metabolism and biological function of APLP2.
Annals of the New York Academy of Sciences 1996;777():77-81.
1996: Donald L Price; David R Borchelt; Philip C Wong; CARLOS PARDO-VILLAMIZAR; Gopal Thinakaran; Michael K Lee; Don W Cleveland; Sangram S Sisodia
Neurodegenerative diseases and model systems.
Cold Spring Harbor symposia on quantitative biology 1996;61():725-38.
1995: Gopal Thinakaran; C A Kitt; A J Roskams; Hilda H Slunt; Eliezer Masliah; C von Koch; Stephen D. Ginsberg; Gabriele V Ronnett; Randall R Reed; Donald L Price
Distribution of an APP homolog, APLP2, in the mouse olfactory system: a potential role for APLP2 in axogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(10):6314-26.
1995: M T Webster; N Groome; Paul T Francis; B R Pearce; F E Sherriff; Gopal Thinakaran; K M Felsenstein; Wilma Wasco; Rudolph E Tanzi; DM Bowen
A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media.
The Biochemical journal 1995;310 ( Pt 1)():95-9.
1995: Gopal Thinakaran; Hilda H Slunt; Sangram S Sisodia
Novel regulation of chondroitin sulfate glycosaminoglycan modification of amyloid precursor protein and its homologue, APLP2.
The Journal of biological chemistry 1995;270(28):16522-5.
1995: Amy Lo; Gopal Thinakaran; Hilda H Slunt; Sangram S Sisodia
Metabolism of the amyloid precursor-like protein 2 in MDCK cells. Polarized trafficking occurs independent of the chondroitin sulfate glycosaminoglycan chain.
The Journal of biological chemistry 1995;270(21):12641-5.
1994: Gopal Thinakaran; Sangram S Sisodia
Amyloid precursor-like protein 2 (APLP2) is modified by the addition of chondroitin sulfate glycosaminoglycan at a single site.
The Journal of biological chemistry 1994;269(35):22099-104.
1994: Hilda H Slunt; Gopal Thinakaran; C Von Koch; Amy Lo; Rudolph E Tanzi; Sangram S Sisodia
Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).
The Journal of biological chemistry 1994;269(4):2637-44.
1993: Gopal Thinakaran; Jnanankur Bag
Expression of the protooncogene c-jun is maintained during myogenic differentiation in rat L6 myoblasts.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1993;71(5-6):260-9.
1993: Gopal Thinakaran; J Ojala; Jnanankur Bag
Expression of c-jun/AP-1 during myogenic differentiation in mouse C2C12 myoblasts.
FEBS letters 1993;319(3):271-6.
1993: Gopal Thinakaran; Jnanankur Bag
Regulation of c-jun/AP-1 expression in rat L6 myoblasts.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1993;71(3-4):197-204.
1991: Gopal Thinakaran; Jnanankur Bag
Alterations in the expression of muscle-specific genes mediated by troponin C antisense oligodeoxynucleotide.
Experimental cell research 1991;192(1):227-35.