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Jürgen Thomale

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Tea Berulava; Ludger Klein-Hitpass; Emil Mladenov; Ulrich Rüther; Jürgen Thomale; Matthias Ziehe; Bernhard Horsthemke
FTO levels affect RNA modification and the transcriptome.
Lars Boeckmann; Ann-Christin Nickel; Christiane Kuschal; Annika Schaefer; Kai-Martin Thoms; Michael P Schön; Jürgen Thomale; Steffen Emmert
Temozolomide chemoresistance heterogeneity in melanoma with different treatment regimens: DNA damage accumulation contribution.
shanta dhar; Zhuang Liu; Jürgen Thomale; Hongjie Dai; Stephen J Lippard
Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device.

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All Publications

2013: Tea Berulava; Ludger Klein-Hitpass; Emil Mladenov; Ulrich Rüther; Jürgen Thomale; Matthias Ziehe; Bernhard Horsthemke
FTO levels affect RNA modification and the transcriptome.
European journal of human genetics : EJHG 2013;21(3):317-23.
2011: Lars Boeckmann; Ann-Christin Nickel; Christiane Kuschal; Annika Schaefer; Kai-Martin Thoms; Michael P Schön; Jürgen Thomale; Steffen Emmert
Temozolomide chemoresistance heterogeneity in melanoma with different treatment regimens: DNA damage accumulation contribution.
Melanoma research 2011;21(3):206-16.
2008: shanta dhar; Zhuang Liu; Jürgen Thomale; Hongjie Dai; Stephen J Lippard
Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device.
Journal of the American Chemical Society 2008;130(34):11467-76.
2008: Michael D Milsom; Moran Jerabek-Willemsen; Chad E Harris; Axel Schambach; Emily Broun; Jeff Bailey; Michael Jansen; David Schleimer; Kalpana Nattamai; Jamie Wilhelm; Amanda Watson; Hartmut Geiger; Geoffrey P Margison; Thomas Moritz; Christopher Baum; Jürgen Thomale; David A Williams
Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells.
Cancer research 2008;68(15):6171-80.
2007: Anna Dzagnidze; Zaza Katsarava; Julia Makhalova; Bernd Liedert; Min-Suk Yoon; Holger Kaube; Volker Limmroth; Jürgen Thomale
Repair capacity for platinum-DNA adducts determines the severity of cisplatin-induced peripheral neuropathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(35):9451-7.
2007: Ursula R Sorg; Veronika Kleff; Sepideh Fanaei; Alexandra Schumann; Michael Moellmann; Bertram Opalka; Jürgen Thomale; Thomas Moritz
O6-methylguanine-DNA-methyltransferase (MGMT) gene therapy targeting haematopoietic stem cells: studies addressing safety issues.
DNA repair 2007;6(8):1197-209.
2006: Andreas Hüttmann; Ludger Klein-Hitpass; Jürgen Thomale; R Deenen; A Carpinteiro; Holger Nückel; Peter Ebeling; Anja Führer; J Edelmann; Ludger Sellmann; Ulrich Dührsen; Jan Dürig
Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status.
Leukemia 2006;20(10):1774-82.
2006: Jan Peter Thomas; Jürgen Lautermann; Bernd Liedert; Frank Seiler; Jürgen Thomale
High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisplatin but not carboplatin ototoxicity.
Molecular pharmacology 2006;70(1):23-9.
2006: Tomke U Bracker; Bernd Giebel; Jan Spanholtz; Ursula R Sorg; Ludger Klein-Hitpass; Thomas Moritz; Jürgen Thomale
Stringent regulation of DNA repair during human hematopoietic differentiation: a gene expression and functional analysis.
Stem cells (Dayton, Ohio) 2006;24(3):722-30.
2006: Bernd Liedert; Dick Pluim; Jan Schellens; Jürgen Thomale
Adduct-specific monoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei.
Nucleic acids research 2006;34(6):e47.
2005: Verena Materna; Bernd Liedert; Jürgen Thomale; Hermann Lage
Protection of platinum-DNA adduct formation and reversal of cisplatin resistance by anti-MRP2 hammerhead ribozymes in human cancer cells.
International journal of cancer. Journal international du cancer 2005;115(3):393-402.
2003: Bernd Liedert; Verena Materna; Dirk Schadendorf; Jürgen Thomale; Hermann Lage
Overexpression of cMOAT (MRP2/ABCC2) is associated with decreased formation of platinum-DNA adducts and decreased G2-arrest in melanoma cells resistant to cisplatin.
The Journal of investigative dermatology 2003;121(1):172-6.
2002: Claudia Buschfort-Papewalis; Thomas Moritz; Bernd Liedert; Jürgen Thomale
Down-regulation of DNA repair in human CD34(+) progenitor cells corresponds to increased drug sensitivity and apoptotic response.
Blood 2002;100(3):845-53.
2000: J Engelbergs; Jürgen Thomale; Manfred F Rajewsky
Role of DNA repair in carcinogen-induced ras mutation.
Mutation research 2000;450(1-2):139-53.
2000: Manfred F Rajewsky; J Engelbergs; Jürgen Thomale; T Schweer
DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance.
Mutation research 2000;462(2-3):101-5.
1999: Y Goto; T Matsuda; K Ito; N H Huh; Jürgen Thomale; Manfred F Rajewsky; Hikoya Hayatsu; Tomoe Negishi
Mutagenicities of N-nitrosodimethylamine and N-nitrosodiethylamine in Drosophila and their relationship to the levels of O-alkyl adducts in DNA.
Mutation research 1999;425(1):125-34.
1998: J Engelbergs; Jürgen Thomale; A Galhoff; Manfred F Rajewsky
Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1635-40.
1998: Manfred F Rajewsky; J Engelbergs; Jürgen Thomale; T Schweer
Relevance of DNA repair to carcinogenesis and cancer therapy.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1998;154():127-46.
1997: Frank Seiler; K Kamino; M Emura; Ulrich Mohr; Jürgen Thomale
Formation and persistence of the miscoding DNA alkylation product O6-ethylguanine in male germ cells of the hamster.
Mutation research 1997;385(3):205-11.
1997: MR Müller; C Buschfort; Jürgen Thomale; C Lensing; Manfred F Rajewsky; Siegfried Seeber
DNA repair and cellular resistance to alkylating agents in chronic lymphocytic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(11):2055-61.
1997: C Buschfort; Ron Muller; Siegfried Seeber; Manfred F Rajewsky; Jürgen Thomale
DNA excision repair profiles of normal and leukemic human lymphocytes: functional analysis at the single-cell level.
Cancer research 1997;57(4):651-8.
1997: Joost H M van Delft; Marie-Jose S T Steenwinkel; Anton J de Groot; Albert A van Zeeland; G Eberle-Adamkiewicz; Manfred F Rajewsky; Jürgen Thomale; RA Baan
Determination of N7- and O6-methylguanine in rat liver DNA after oral exposure to hydrazine by use of immunochemical and electrochemical detection methods.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1997;35(1):131-7.
1996: E J Mientjes; K Hochleitner; A Luiten-Schuite; Joost H M van Delft; Jürgen Thomale; F Berends; Manfred F Rajewsky; P H Lohman; RA Baan
Formation and persistence of O6-ethylguanine in genomic and transgene DNA in liver and brain of lambda(lacZ) transgenic mice treated with N-ethyl-N-nitrosourea.
Carcinogenesis 1996;17(11):2449-54.
1996: Ekkehart W Vogel; Madeleine J M Nivard; L A Ballering; H Bartsch; Alain Barbin; Urmila Nair; Miguel A Comendador; L María Sierra; I Aguirrezabalaga; L Tosal; Lars Ehrenberg; Robert Fuchs; Régine Janel-Bintz; G Maenhaut-Michel; R Montesano; J Hall; H Kang; M Miele; Jürgen Thomale; K Bender; J Engelbergs; Manfred F Rajewsky
DNA damage and repair in mutagenesis and carcinogenesis: implications of structure-activity relationships for cross-species extrapolation.
Mutation research 1996;353(1-2):177-218.
1995: Kenji Kamino; Frank Seiler; M Emura; Jürgen Thomale; Manfred F Rajewsky; Ulrich Mohr
Formation of O6-ethylguanine in spermatogonial DNA of adult Syrian golden hamster by intraperitoneal injection of diethylnitrosamine.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1995;47(6):443-5.
1994: MR Müller; Frank Seiler; Jürgen Thomale; C Buschfort; Manfred F Rajewsky; Siegfried Seeber
Capacity of individual chronic lymphatic leukemia lymphocytes and leukemic blast cells for repair of O6-ethylguanine in DNA: relation to chemosensitivity in vitro and treatment outcome.
Cancer research 1994;54(16):4524-31.
1994: Jürgen Thomale; Frank Seiler; MR Müller; Siegfried Seeber; Manfred F Rajewsky
Repair of O6-alkylguanines in the nuclear DNA of human lymphocytes and leukaemic cells: analysis at the single-cell level.
British journal of cancer 1994;69(4):698-705.
1994: Jürgen Thomale; K Hochleitner; Manfred F Rajewsky
Differential formation and repair of the mutagenic DNA alkylation product O6-ethylguanine in transcribed and nontranscribed genes of the rat.
The Journal of biological chemistry 1994;269(3):1681-6.
1994: C Schell; O Lantermann; Walter Popp; C Vahrenholz; Jürgen Thomale; R Gugova; Evgeny Golovinsky; K Norpoth
Genotoxic and cytotoxic effects of 4-aroyl-1-nitrosohydrazine-carboxamides on O6-alkylguanine-DNA alkyltransferase-positive and -negative human cell lines.
Journal of cancer research and clinical oncology 1994;120(7):403-8.
1993: MR Müller; Jürgen Thomale; C Lensing; Manfred F Rajewsky; Siegfried Seeber
Chemosensitisation of alkylating agents by pentoxifylline, O6-benzylguanine and ethacrynic acid in haematological malignancies.
Anticancer research 1993;13(6A):2155-9.
1991: K Hochleitner; Jürgen Thomale; Manfred F Rajewsky
Monoclonal antibody-based, selective isolation of DNA fragments containing an alkylated base to be quantified in defined gene sequences.
Nucleic acids research 1991;19(16):4467-72.
1990: Jürgen Thomale; N H Huh; P Nehls; G Eberle; Manfred F Rajewsky
Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9883-7.
1989: G Eberle; Alain Barbin; R J Laib; F Ciroussel; Jürgen Thomale; H Bartsch; Manfred F Rajewsky
1,N6-etheno-2'-deoxyadenosine and 3,N4-etheno-2'-deoxycytidine detected by monoclonal antibodies in lung and liver DNA of rats exposed to vinyl chloride.
Carcinogenesis 1989;10(1):209-12.
1987: M S Satoh; N H Huh; Y Horie; Jürgen Thomale; Manfred F Rajewsky; Toshio Kuroki
Acquisition of resistance to 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride in V79 cells through increased removal of O6-alkylguanine.
Japanese journal of cancer research : Gann 1987;78(10):1094-9.
1986: Manfred F Rajewsky; J Adamkiewicz; G Eberle; N Huh; P Nehls; Jürgen Thomale
Immunological analysis of structural DNA modifications induced by mutagenic and carcinogenic N-nitroso compounds.
Progress in clinical and biological research 1986;209A():199-207.
1985: D Umbenhauer; C P Wild; R Montesano; R Saffhill; J M Boyle; N Huh; U Kirstein; Jürgen Thomale; Manfred F Rajewsky; S H Lu
O(6)-methyldeoxyguanosine in oesophageal DNA among individuals at high risk of oesophageal cancer.
International journal of cancer. Journal international du cancer 1985;36(6):661-5.