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Shaun Thomas

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Physiology

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Emma Hamilton; Liam Morgan; Laurence Pearce; Paul Brennan; Andrea G S Buggins; Stephen Devereux; Christopher Fegan; Sophie Robinson; N Shaun B Thomas; Vicki Ware; Deborah Yallop; Chris Pepper
Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cells.
Joop Gäken; Jie Jiang; Austin G Kulasekararaj; Farooq Malik; Azim Mohamedali; Alexander E Smith; Doris Stangl; Mahvash Tavassoli; N Shaun B Thomas; Constantinos Chronis; Farzin Farzaneh; Ghulam J Mufti
A functional assay for microRNA target identification and validation.
Stephen J Orr; Thivyan Thayaparan; Rong Wang; Eric Blanc; Daniel R Boutz; Constantinos Chronis; Emma Hamilton; Nicholas C Lea; Edward M Marcotte; Hanna Milewicz; Ghulam J Mufti; N Shaun B Thomas
Proteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entry.

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All Publications

2012: Emma Hamilton; Liam Morgan; Laurence Pearce; Paul Brennan; Andrea G S Buggins; Stephen Devereux; Christopher Fegan; Sophie Robinson; N Shaun B Thomas; Vicki Ware; Deborah Yallop; Chris Pepper
Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cells.
British journal of haematology 2012;158(5):589-99.
2012: Joop Gäken; Jie Jiang; Austin G Kulasekararaj; Farooq Malik; Azim Mohamedali; Alexander E Smith; Doris Stangl; Mahvash Tavassoli; N Shaun B Thomas; Constantinos Chronis; Farzin Farzaneh; Ghulam J Mufti
A functional assay for microRNA target identification and validation.
Nucleic acids research 2012;40(10):e75.
2012: Stephen J Orr; Thivyan Thayaparan; Rong Wang; Eric Blanc; Daniel R Boutz; Constantinos Chronis; Emma Hamilton; Nicholas C Lea; Edward M Marcotte; Hanna Milewicz; Ghulam J Mufti; N Shaun B Thomas
Proteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entry.
Molecular systems biology 2012;8():573.
2011: Rachael L Wojtala; Penny E Morton; Ignatius A Tavares; N Shaun B Thomas; Ferran Valderrama; Jonathan D H Morris
Prostate-derived sterile 20-like kinases (PSKs/TAOKs) are activated in mitosis and contribute to mitotic cell rounding and spindle positioning.
The Journal of biological chemistry 2011;286(34):30161-70.
2011: Leo M Carlin; Ton Coolen; Rachel Evans; Luis Fernandes; Franca Fraternali; Melanie D Keppler; James Levitt; Daniel R Matthews; Hanna Milewicz; James Monypenny; Peter J Parker; Michela Perani; Klaus Suhling; N Shaun B Thomas; Borivoj Vojnovic; Simon M Ameer-Beg; Paul Richard Barber; Tony Ng
A targeted siRNA screen identifies regulators of Cdc42 activity at the natural killer cell immunological synapse.
Science signaling 2011;4(201):ra81.
2010: Andrea G S Buggins; Chris Pepper; Piers E M Patten; Saman Hewamana; Satyen Gohil; Jane Moorhead; Najeem'deen Folarin; Deborah Yallop; N Shaun B Thomas; Ghulam J Mufti; Christopher Fegan; Stephen Devereux
Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription.
Cancer research 2010;70(19):7523-33.
2009: Alexander E Smith; Constantinos Chronis; Manolis Christodoulakis; Stephen J Orr; Nicholas C Lea; Natalie A Twine; Akshay Bhinge; Ghulam J Mufti; N Shaun B Thomas
Epigenetics of human T cells during the G0-->G1 transition.
Genome research 2009;19(8):1325-37.
2009: Azim Mohamedali; Barbara-ann Guinn; Satyajit Sahu; N Shaun B Thomas; Ghulam J Mufti
Serum profiling reveals distinctive proteomic markers in chronic myeloid leukaemia patients.
British journal of haematology 2009;144(2):263-5.
2008: Barbara Guinn; Lars Bullinger; N Shaun B Thomas; Ken Mills; Jochen Greiner
SSX2IP expression in acute myeloid leukaemia: an association with mitotic spindle failure in t(8;21), and cell cycle in t(15;17) patients.
British journal of haematology 2008;140(2):250-1.
2007: Nader Omidvar; Scott C Kogan; Stephanie Beurlet; Carole le Pogam; Anne Janin; Robert R West; Maria-Elena Noguera; Murielle Reboul; Annie Soulie; Christophe Leboeuf; Niclas Setterblad; Dean W Felsher; Eric Lagasse; Azim Mohamedali; N Shaun B Thomas; Pierre Fenaux; Michaela Fontenay; Marika Pla; Ghulam J Mufti; Irving Weissman; Christine Chomienne; Rose Ann Padua
BCL-2 and mutant NRAS interact physically and functionally in a mouse model of progressive myelodysplasia.
Cancer research 2007;67(24):11657-67.
2007: K Raj; A John; A Ho; C Chronis; S Khan; J Samuel; S Pomplun; N Shaun B Thomas; Ghulam J Mufti
CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine.
Leukemia 2007;21(9):1937-44.
2007: Barbara Guinn; Azim Mohamedali; N Shaun B Thomas; Ken Mills
Immunotherapy of myeloid leukaemia.
Cancer immunology, immunotherapy : CII 2007;56(7):943-57.
2006: Inês Soeiro; Azim Mohamedali; Hanna M Romanska; Nicholas C Lea; Emma S Child; Janet Glassford; Stephen J Orr; Claudia Roberts; Kikkeri N Naresh; El-Nasir Lalani; David J Mann; Roger J Watson; N Shaun B Thomas; Eric W-F Lam
p27Kip1 and p130 cooperate to regulate hematopoietic cell proliferation in vivo.
Molecular and cellular biology 2006;26(16):6170-84.
2005: Dragana Milojkovic; Andrea G S Buggins; S Devereux; N Shaun B Thomas; Ghulam J Mufti
Tumor supernatant from myeloid malignancies inhibits T-cell apoptosis and cell cycle entry independently.
Leukemia 2005;19(9):1699-702.
2005: Abdelkader Essafi; Silvia Fernández de Mattos; Yasmin A M Hassen; Inês Soeiro; Ghulam J Mufti; N Shaun B Thomas; René H Medema; Eric W-F Lam
Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.
Oncogene 2005;24(14):2317-29.
2004: Dragana Milojkovic; Stephen Devereux; Nigel B Westwood; Ghulam J Mufti; N Shaun B Thomas; Andrea G S Buggins
Antiapoptotic microenvironment of acute myeloid leukemia.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6745-52.
2004: Alison M John; N Shaun B Thomas; Ghulam J Mufti; Rose Ann Padua
Targeted therapies in myeloid leukemia.
Seminars in cancer biology 2004;14(1):41-62.
2003: Azim Mohamedali; Inês Soeiro; Nicholas C Lea; Janet Glassford; Lolita Banerji; Ghulam J Mufti; Eric W-F Lam; N Shaun B Thomas
Cyclin D2 controls B cell progenitor numbers.
Journal of leukocyte biology 2003;74(6):1139-43.
2003: Nicholas C Lea; Stephen J Orr; Kai Stoeber; Gareth H Williams; Eric W-F Lam; Mohammad A A Ibrahim; Ghulam J Mufti; N Shaun B Thomas
Commitment point during G0-->G1 that controls entry into the cell cycle.
Molecular and cellular biology 2003;23(7):2351-61.
2003: Nicholas C Lea; Andrea G S Buggins; Stephen J Orr; Ghulam J Mufti; N Shaun B Thomas
High efficiency protein transduction of quiescent and proliferating primary hematopoietic cells.
Journal of biochemical and biophysical methods 2003;55(3):251-8.
2002: M A Helal; Huseyin Mehmet; N Shaun B Thomas; Phillip M Cox; David J Ralph; Rekha Bajoria; Ratna Chatterjee
Ontogeny of human fetal testicular apoptosis during first, second, and third trimesters of pregnancy.
The Journal of clinical endocrinology and metabolism 2002;87(3):1189-93.
2002: Pascale F Dijkers; Kim U Birkenkamp; Eric W-F Lam; N Shaun B Thomas; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity.
The Journal of cell biology 2002;156(3):531-42.
2002: Kwee Yong; Anne Fahey; Gurmit Pahal; David C Linch; Arnold Pizzey; N Shaun B Thomas; Eric Jauniaux; Christine Kinnon; Adrian J Thrasher
Fetal haemopoietic cells display enhanced migration across endothelium.
British journal of haematology 2002;116(2):392-400.
2001: Andrea G S Buggins; Dragana Milojkovic; Matthew Arno; Nicholas C Lea; Ghulam J Mufti; N Shaun B Thomas; WJ Hirst
Microenvironment produced by acute myeloid leukemia cells prevents T cell activation and proliferation by inhibition of NF-kappaB, c-Myc, and pRb pathways.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):6021-30.
2001: Lolita Banerji; Janet Glassford; Nicholas C Lea; N Shaun B Thomas; Gerry G B Klaus; Eric W-F Lam
BCR signals target p27(Kip1) and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells.
Oncogene 2001;20(50):7352-67.
2001: Y Parada; Lolita Banerji; Janet Glassford; Nicholas C Lea; Manuel Collado; C Rivas; John L Lewis; Myrtle Y Gordon; N Shaun B Thomas; Eric W-F Lam
BCR-ABL and interleukin 3 promote haematopoietic cell proliferation and survival through modulation of cyclin D2 and p27Kip1 expression.
The Journal of biological chemistry 2001;276(26):23572-80.
2001: John L Lewis; W Chinswangwatanakul; B Zheng; Stephen B Marley; DX Nguyen; Nicholas C P Cross; Lolita Banerji; Janet Glassford; N Shaun B Thomas; John M Goldman; Eric W-F Lam; Myrtle Y Gordon
The influence of INK4 proteins on growth and self-renewal kinetics of hematopoietic progenitor cells.
Blood 2001;97(9):2604-10.
2001: Kirit M Ardeshna; Forhad Ahmed; Stephen Devereux; N Shaun B Thomas
The retinoblastoma family member, p107, is active in non-dividing monocyte-derived dendritic cells.
British journal of haematology 2001;112(3):655-7.
2000: Pascale F Dijkers; René H Medema; CM Pals; Lolita Banerji; N Shaun B Thomas; Eric W-F Lam; Boudewijn M T Burgering; Jan A M Raaijmakers; Jan-Willem J Lammers; Leo Koenderman; Paul J Coffer
Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).
Molecular and cellular biology 2000;20(24):9138-48.
2000: Kirit M Ardeshna; Arnold Pizzey; N Shaun B Thomas; S Orr; David C Linch; Stephen Devereux
Monocyte-derived dendritic cells do not proliferate and are not susceptible to retroviral transduction.
British journal of haematology 2000;108(4):817-24.
2000: Eric W-F Lam; Janet Glassford; Lolita Banerji; N Shaun B Thomas; Piotr Sicinski; Gerry G B Klaus
Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40.
The Journal of biological chemistry 2000;275(5):3479-84.
1999: Kwee Yong; Anne Fahey; L Reeve; C Nicholls; N Shaun B Thomas; Arnold Pizzey; Stuart J Ings; Michael J Watts; David C Linch
Cord blood progenitor cells have greater transendothelial migratory activity and increased responses to SDF-1 and MIP-3beta compared with mobilized adult progenitor cells.
British journal of haematology 1999;107(2):441-9.
1999: J van der Sman; N Shaun B Thomas; Eric W-F Lam
Modulation of E2F complexes during G0 to S phase transition in human primary B-lymphocytes.
The Journal of biological chemistry 1999;274(17):12009-16.
1998: N Shaun B Thomas; Arnold Pizzey; S Tiwari; Catherine D Williams; J Yang
p130, p107, and pRb are differentially regulated in proliferating cells and during cell cycle arrest by alpha-interferon.
The Journal of biological chemistry 1998;273(37):23659-67.
1998: Robert S Coffin; SK Thomas; N Shaun B Thomas; Caroline E Lilley; Arnold Pizzey; C H Griffiths; Barry J Gibb; MJ Wagstaff; S J Inges; Michael Binks; Benjamin M Chain; Adrian J Thrasher; Karine Rutault; David S Latchman
Pure populations of transduced primary human cells can be produced using GFP expressing herpes virus vectors and flow cytometry.
Gene therapy 1998;5(5):718-22.
1997: Catherine D Williams; David C Linch; Michael J Watts; N Shaun B Thomas
Characterization of cell cycle status and E2F complexes in mobilized CD34+ cells before and after cytokine stimulation.
Blood 1997;90(1):194-203.
1997: Catherine D Williams; David C Linch; T S Sørensen; Nicholas B La Thangue; N Shaun B Thomas
The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F-4, DP-1 and p130.
British journal of haematology 1997;96(4):688-96.
1996: S J Grenfell; David S Latchman; N Shaun B Thomas
Oct-1 [corrected] and Oct-2 DNA-binding site specificity is regulated in vitro by different kinases.
The Biochemical journal 1996;315 ( Pt 3)():889-93.
1996: R Chopra; G Kendall; Rosemary E Gale; N Shaun B Thomas; David C Linch
Expression of two alternatively spliced forms of the 5' untranslated region of the GM-CSF receptor alpha chain mRNA.
Experimental hematology 1996;24(6):755-62.
1996: R Jamal; N Shaun B Thomas; Rosemary E Gale; David C Linch
Variable expression of p16 protein in patients with acute myeloid leukemia without gross rearrangements at the DNA level.
Leukemia 1996;10(4):629-36.
1995: N D Lakin; R Palmer; K A Lillycrop; M K Howard; L C Burke; N Shaun B Thomas; David S Latchman
Down regulation of the octamer binding protein Oct-1 during growth arrest and differentiation of a neuronal cell line.
Brain research. Molecular brain research 1995;28(1):47-54.
1994: PJ Roberts; Asim Khwaja; A K Lie; A Bybee; Kwee Yong; N Shaun B Thomas; David C Linch
Differentiation-linked changes in tyrosine phosphorylation, functional activity, and gene expression downstream from the granulocyte-macrophage colony-stimulating factor receptor.
Blood 1994;84(4):1064-73.
1993: M K Howard; L C Burke; C Mailhos; Arnold Pizzey; C S Gilbert; W D Lawson; M K Collins; N Shaun B Thomas; David S Latchman
Cell cycle arrest of proliferating neuronal cells by serum deprivation can result in either apoptosis or differentiation.
Journal of neurochemistry 1993;60(5):1783-91.
1992: A Bybee; N Shaun B Thomas
The synthesis of p58cyclin A and the phosphorylation of p34cdc2 are inhibited in human lymphoid cells arrested in G1 by alpha-interferon.
Biochimica et biophysica acta 1992;1137(1):73-6.
1992: V Devalia; N Shaun B Thomas; PJ Roberts; Hilary Jones; David C Linch
Down-regulation of human protein kinase C alpha is associated with terminal neutrophil differentiation.
Blood 1992;80(1):68-76.
1992: L C Burke; A Bybee; N Shaun B Thomas
The retinoblastoma protein is partially phosphorylated during early G1 in cycling cells but not in G1 cells arrested with alpha-interferon.
Oncogene 1992;7(4):783-8.
1991: C L Dent; K A Lillycrop; A Bybee; David S Latchman; N Shaun B Thomas
Interferon-alpha treatment of Daudi cells down-regulates the octamer binding transcription/DNA replication factors Oct-1 and Oct-2.
The Journal of biological chemistry 1991;266(31):20888-92.
1991: PJ Roberts; V Devalia; R Faint; Arnold Pizzey; A L Bainton; N Shaun B Thomas; Glenn Pilkington; David C Linch
Differentiation-linked activation of the respiratory burst in a monocytic cell line (U937) via Fc gamma RII. A study of activation pathways and their regulation.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(9):3104-15.
1991: A Bybee; N Shaun B Thomas
Cell cycle regulation.
Blood reviews 1991;5(3):177-92.
1991: C L Dent; K A Lillycrop; J K Estridge; N Shaun B Thomas; David S Latchman
The B-cell and neuronal forms of the octamer-binding protein Oct-2 differ in DNA-binding specificity and functional activity.
Molecular and cellular biology 1991;11(8):3925-30.
1991: N Shaun B Thomas; David C Linch
An intracellular 50-kDa Fc gamma-binding protein is induced in human cells by alpha-IFN.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(5):1649-54.
1991: N Shaun B Thomas; L C Burke; A Bybee; David C Linch
The phosphorylation state of the retinoblastoma (RB) protein in G0/G1 is dependent on growth status.
Oncogene 1991;6(2):317-22.
1990: J G Gribben; Stephen Devereux; N Shaun B Thomas; M Keim; Hilary Jones; Anthony H Goldstone; David C Linch
Development of antibodies to unprotected glycosylation sites on recombinant human GM-CSF.
Lancet 1990;335(8687):434-7.
1989: N Shaun B Thomas
Regulation of the product of a possible human cell cycle control gene CDC2Hs in B-cells by alpha-interferon and phorbol ester.
The Journal of biological chemistry 1989;264(23):13697-700.