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Philip Thomas

Research Profile

Chemicals & Drugs

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Amino Acid Sequences

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Cystic Fibrosis

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Publications

TOP 3
Anna E Patrick; Philip J Thomas
Development of CFTR Structure.
Balajee R Somalinga; Cameron E Day; Michael Roth; Shuguang Wei; Philip J Thomas
TDP-43 identified from a genome wide RNAi screen for SOD1 regulators.
Anna E Patrick; Andrey L Karamyshev; Linda Millen; Philip J Thomas
Alteration of CFTR transmembrane span integration by disease-causing mutations.

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All Publications

2012: Anna E Patrick; Philip J Thomas
Development of CFTR Structure.
Frontiers in pharmacology 2012;3():162.
2012: Balajee R Somalinga; Cameron E Day; Michael Roth; Shuguang Wei; Philip J Thomas
TDP-43 identified from a genome wide RNAi screen for SOD1 regulators.
PloS one 2012;7(4):e35818.
2011: Anna E Patrick; Andrey L Karamyshev; Linda Millen; Philip J Thomas
Alteration of CFTR transmembrane span integration by disease-causing mutations.
Molecular biology of the cell 2011;22(23):4461-71.
2011: Balajee R Somalinga; Hiba T Malik; Gregory A Miller; W Christian Wigley; Philip J Thomas
A screen to identify cellular modulators of soluble levels of an amyotrophic lateral sclerosis (ALS)-causing mutant SOD1.
Journal of biomolecular screening 2011;16(9):974-85.
2011: André Schmidt; Juan L Mendoza; Philip J Thomas
Biochemical and biophysical approaches to probe CFTR structure.
Methods in molecular biology (Clifton, N.J.) 2011;741():365-76.
2011: Juan L Mendoza; André Schmidt; Philip J Thomas
Introduction to section IV: biophysical methods to approach CFTR structure.
Methods in molecular biology (Clifton, N.J.) 2011;741():321-7.
2010: Karen A Lewis; Yang Su; Olina Jou; Caroline Ritchie; Chan Foong; Linda Hynan; Charles L White; Philip J Thomas; Kimmo J Hatanpaa
Abnormal neurites containing C-terminally truncated alpha-synuclein are present in Alzheimer's disease without conventional Lewy body pathology.
The American journal of pathology 2010;177(6):3037-50.
2010: Li Zhu; Linda Millen; Juan L Mendoza; Philip J Thomas
A unique redox-sensing sensor II motif in TorsinA plays a critical role in nucleotide and partner binding.
The Journal of biological chemistry 2010;285(48):37271-80.
2010: Karen A Lewis; Arynn Yaeger; George N DeMartino; Philip J Thomas
Accelerated formation of alpha-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations.
Journal of bioenergetics and biomembranes 2010;42(1):85-95.
2008: Li Zhu; James O Wrabl; Adam P Hayashi; Lesilee S Rose; Philip J Thomas
The torsin-family AAA+ protein OOC-5 contains a critical disulfide adjacent to Sensor-II that couples redox state to nucleotide binding.
Molecular biology of the cell 2008;19(8):3599-612.
2008: Michael R Dorwart; Nikolay Shcheynikov; Jennifer M R Baker; Julie D Forman-Kay; Shmuel Muallem; Philip J Thomas
Congenital chloride-losing diarrhea causing mutations in the STAS domain result in misfolding and mistrafficking of SLC26A3.
The Journal of biological chemistry 2008;283(13):8711-22.
2007: Juan L Mendoza; Philip J Thomas
Building an understanding of cystic fibrosis on the foundation of ABC transporter structures.
Journal of bioenergetics and biomembranes 2007;39(5-6):499-505.
2006: Youxue Wang; Abigail A Soyombo; Nikolay Shcheynikov; Weizhong Zeng; Michael R Dorwart; Christopher R Marino; Philip J Thomas; Shmuel Muallem
Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosis.
The EMBO journal 2006;25(21):5049-57.
2006: Changwei Liu; Xiaohua Li; David Thompson; Kerry Wooding; Tsui-ling Chang; Zhanyun Tang; Hongtao Yu; Philip J Thomas; George N DeMartino
ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome.
Molecular cell 2006;24(1):39-50.
2006: Nikolay Shcheynikov; Youxue Wang; Meeyoung Park; Shigeru B H Ko; Michael R Dorwart; Satoru Naruse; Philip J Thomas; Shmuel Muallem
Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6.
The Journal of general physiology 2006;127(5):511-24.
2006: Nikolay Shcheynikov; Shigeru B H Ko; Weizhong Zeng; Joo Young Choi; Michael R Dorwart; Philip J Thomas; Shmuel Muallem
Regulatory interaction between CFTR and the SLC26 transporters.
Novartis Foundation symposium 2006;273():177-86; discussion 186-92, 261-4.
2005: Jonathan E Moody; Philip J Thomas
Nucleotide binding domain interactions during the mechanochemical reaction cycle of ATP-binding cassette transporters.
Journal of bioenergetics and biomembranes 2005;37(6):475-9.
2005: Changwei Liu; Benoit I Giasson; Karen A Lewis; Virginia M-Y Lee; George N DeMartino; Philip J Thomas
A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease.
The Journal of biological chemistry 2005;280(24):22670-8.
2005: Michael J Corboy; Philip J Thomas; W Christian Wigley
Aggresome formation.
Methods in molecular biology (Clifton, N.J.) 2005;301():305-27.
2005: Changwei Liu; Elizabeth Strickland; George N DeMartino; Philip J Thomas
Recognition and processing of misfolded proteins by PA700, the 19S regulatory complex of the 26S proteasome.
Methods in molecular biology (Clifton, N.J.) 2005;301():71-81.
2005: Patrick H Thibodeau; Chad A Brautigam; Mischa Machius; Philip J Thomas
Side chain and backbone contributions of Phe508 to CFTR folding.
Nature structural & molecular biology 2005;12(1):10-6.
2004: Nikolay Shcheynikov; Kil Hwan Kim; Kyung-Mi Kim; Michael R Dorwart; Shigeru B H Ko; Hidemi Goto; Satoru Naruse; Philip J Thomas; Shmuel Muallem
Dynamic control of cystic fibrosis transmembrane conductance regulator Cl(-)/HCO3(-) selectivity by external Cl(-).
The Journal of biological chemistry 2004;279(21):21857-65.
2004: Shigeru B H Ko; Weizhong Zeng; Michael R Dorwart; Xiang Luo; Kil Hwan Kim; Linda Millen; Hidemi Goto; Satoru Naruse; Abigail A Soyombo; Philip J Thomas; Shmuel Muallem
Gating of CFTR by the STAS domain of SLC26 transporters.
Nature cell biology 2004;6(4):343-50.
2004: Stephanie Shriver; Sean G Buchanan; Stephen K Burley; Kris Conners; Mark Dickey; Michael Dorwart; Richard Fowler; Xia Gao; William B Guggino; Wayne A Hendrickson; John F Hunt; Margaret C Kearins; Don Lorimer; Peter C Maloney; Kai W Post; Kanagalaghatta R Rajashankar; Marc E Rutter; J Michael Sauder; Stephanie Shriver; Patrick H Thibodeau; Philip J Thomas; Marie Zhang; Xun Zhao; Spencer Emtage
Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
The EMBO journal 2004;23(2):282-93.
2003: Changwei Liu; Michael J Corboy; George N DeMartino; Philip J Thomas
Endoproteolytic activity of the proteasome.
Science (New York, N.Y.) 2003;299(5605):408-11.
2003: Rhesa D Stidham; W Christian Wigley; John F Hunt; Philip J Thomas
Assessment of protein folding/solubility in live cells.
Methods in molecular biology (Clifton, N.J.) 2003;205():155-69.
2002: Meeyoung Park; Shigeru B H Ko; Joo Young Choi; Gaia Muallem; Philip J Thomas; Alexander Pushkin; Myeong-Sok Lee; Joo Young Kim; Min Goo Lee; Shmuel Muallem; Ira Kurtz
The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3.
The Journal of biological chemistry 2002;277(52):50503-9.
2002: Shigeru B H Ko; Nikolay Shcheynikov; Joo Young Choi; Xiang Luo; Kenichi Ishibashi; Philip J Thomas; Joo Young Kim; Kyung Hwan Kim; Min Goo Lee; Satoru Naruse; Shmuel Muallem
A molecular mechanism for aberrant CFTR-dependent HCO(3)(-) transport in cystic fibrosis.
The EMBO journal 2002;21(21):5662-72.
2002: Changwei Liu; Linda Millen; Tracie B Roman; Hai Xiong; Hiram F Gilbert; Robert Noiva; George N DeMartino; Philip J Thomas
Conformational remodeling of proteasomal substrates by PA700, the 19 S regulatory complex of the 26 S proteasome.
The Journal of biological chemistry 2002;277(30):26815-20.
2002: Paul C Smith; Nathan K Karpowich; Linda Millen; Jonathan E Moody; Jane Rosen; Philip J Thomas; John F Hunt
ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer.
Molecular cell 2002;10(1):139-49.
2002: Jonathan E Moody; Linda Millen; Derk D Binns; John F Hunt; Philip J Thomas
Cooperative, ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transporters.
The Journal of biological chemistry 2002;277(24):21111-4.
2002: W Christian Wigley; Michael J Corboy; Todd D Cutler; Patrick H Thibodeau; Jorge Oldan; Min Goo Lee; Josep Rizo; John F Hunt; Philip J Thomas
A protein sequence that can encode native structure by disfavoring alternate conformations.
Nature structural biology 2002;9(5):381-8.
2002: Rhesa D Stidham; W Christian Wigley; Philip J Thomas
In vitro CFTR folding assays.
Methods in molecular medicine 2002;70():311-22.
2002: Michael J Corboy; Philip J Thomas; W Christian Wigley
CFTR degradation and aggregation.
Methods in molecular medicine 2002;70():277-94.
2001: Yu-Ren Yuan; S Blecker; Oskana Martsinkevich; Linda Millen; Philip J Thomas; John F Hunt
The crystal structure of the MJ0796 ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter.
The Journal of biological chemistry 2001;276(34):32313-21.
2001: Nathan K Karpowich; Oskana Martsinkevich; Linda Millen; Yu-Ren Yuan; P L Dai; K MacVey; Philip J Thomas; John F Hunt
Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter.
Structure (London, England : 1993) 2001;9(7):571-86.
2001: Joo Young Choi; D Muallem; Kirill Kiselyov; Min Goo Lee; Philip J Thomas; Shmuel Muallem
Aberrant CFTR-dependent HCO3- transport in mutations associated with cystic fibrosis.
Nature 2001;410(6824):94-7.
2001: W Christian Wigley; Rhesa D Stidham; N M Smith; John F Hunt; Philip J Thomas
Protein solubility and folding monitored in vivo by structural complementation of a genetic marker protein.
Nature biotechnology 2001;19(2):131-6.
2001: Rosalind P Fabunmi; W Christian Wigley; Philip J Thomas; George N DeMartino
Interferon gamma regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies.
Journal of cell science 2001;114(Pt 1):29-36.
2000: Elizabeth Strickland; K Hakala; Philip J Thomas; George N DeMartino
Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome.
The Journal of biological chemistry 2000;275(8):5565-72.
2000: Rosalind P Fabunmi; W Christian Wigley; Philip J Thomas; George N DeMartino
Activity and regulation of the centrosome-associated proteasome.
The Journal of biological chemistry 2000;275(1):409-13.
1999: W Christian Wigley; Rosalind P Fabunmi; Min Goo Lee; Christopher R Marino; Shmuel Muallem; George N DeMartino; Philip J Thomas
Dynamic association of proteasomal machinery with the centrosome.
The Journal of cell biology 1999;145(3):481-90.
1999: Min Goo Lee; W Christian Wigley; Weizhong Zeng; L E Noel; Christopher R Marino; Philip J Thomas; Shmuel Muallem
Regulation of Cl-/ HCO3- exchange by cystic fibrosis transmembrane conductance regulator expressed in NIH 3T3 and HEK 293 cells.
The Journal of biological chemistry 1999;274(6):3414-21.
1998: W Christian Wigley; S Vijayakumar; J D Jones; C Slaughter; Philip J Thomas
Transmembrane domain of cystic fibrosis transmembrane conductance regulator: design, characterization, and secondary structure of synthetic peptides m1-m6.
Biochemistry 1998;37(3):844-53.
1997: Elizabeth Strickland; BH Qu; Linda Millen; Philip J Thomas
The molecular chaperone Hsc70 assists the in vitro folding of the N-terminal nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator.
The Journal of biological chemistry 1997;272(41):25421-4.
1997: BH Qu; Elizabeth Strickland; Philip J Thomas
Cystic fibrosis: a disease of altered protein folding.
Journal of bioenergetics and biomembranes 1997;29(5):483-90.
1997: BH Qu; Elizabeth Strickland; Philip J Thomas
Localization and suppression of a kinetic defect in cystic fibrosis transmembrane conductance regulator folding.
The Journal of biological chemistry 1997;272(25):15739-44.
1996: B H Qu; Philip J Thomas
Alteration of the cystic fibrosis transmembrane conductance regulator folding pathway.
The Journal of biological chemistry 1996;271(13):7261-4.
1995: Philip J Thomas; B H Qu; Peter L Pedersen
Defective protein folding as a basis of human disease.
Trends in biochemical sciences 1995;20(11):456-9.