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Peter Boross

Research Profile

Chemicals & Drugs

Living Beings

HIV-1
Mouse

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Genes & Molecular Sequences

Amino Acid Sequences

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Publications

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Phoebe E H Sharp; Ivo P Touw; Sjef Verbeek; Peter I Boross; H Terence Cook; Sara M Mangsbo; Javier Martin-Ramirez; Charles D Pusey; Ruth M Tarzi
FcγRIIb on myeloid cells and intrinsic renal cells rather than B cells protects from nephrotoxic nephritis.
Nadine van Montfoort; Peter I Boross; Marcel Camps; Sara M Mangsbo; Cornelis J M Melief; Ferry Ossendorp; Peter A C 't Hoen; Sjef Verbeek
Fcγ receptor IIb strongly regulates Fcγ receptor-facilitated T cell activation by dendritic cells.
Yunfeng Tie; Jozsef Tozser; Yuan-Fang Wang; Peter I Boross; Ting-Yi Chiu; Arun K Ghosh; Robert W Harrison; John M Louis; Irene T Weber
Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.

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All Publications

2013: Phoebe E H Sharp; Ivo P Touw; Sjef Verbeek; Peter I Boross; H Terence Cook; Sara M Mangsbo; Javier Martin-Ramirez; Charles D Pusey; Ruth M Tarzi
FcγRIIb on myeloid cells and intrinsic renal cells rather than B cells protects from nephrotoxic nephritis.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(1):340-8.
2012: Nadine van Montfoort; Peter I Boross; Marcel Camps; Sara M Mangsbo; Cornelis J M Melief; Ferry Ossendorp; Peter A C 't Hoen; Sjef Verbeek
Fcγ receptor IIb strongly regulates Fcγ receptor-facilitated T cell activation by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(1):92-101.
2012: Yunfeng Tie; Jozsef Tozser; Yuan-Fang Wang; Peter I Boross; Ting-Yi Chiu; Arun K Ghosh; Robert W Harrison; John M Louis; Irene T Weber
Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.
Protein science : a publication of the Protein Society 2012;21(3):339-50.
2011: Peter I Boross; Marina Botto; Cor Breukel; Marcel Camps; Francesco Carlucci; Jill W C Claassens; H Terence Cook; Mohamed R Daha; Roelof Flierman; Shozo Izui; Erik Lubberts; Javier Martin-Ramirez; Ferry Ossendorp; Maria Pia Rastaldi; Daniela Salvatori; Marie-Laure Santiago-Raber; Jos van der Kaa; Victoria L Arandhara; Sjef Verbeek
The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(3):1304-13.
2008: János Kádas; Peter I Boross; Irene T Weber; Péter Bagossi; Krisztina Matúz; József Tözsér
C-terminal residues of mature human T-lymphotropic virus type 1 protease are critical for dimerization and catalytic activity.
The Biochemical journal 2008;416(3):357-64.
2008: Helga Eizert; Pálma Bander; Péter Bagossi; Tamás Sperka; Gabriella Miklóssy; Peter I Boross; Irene T Weber; József Tözsér
Amino acid preferences of retroviral proteases for amino-terminal positions in a type 1 cleavage site.
Journal of virology 2008;82(20):10111-7.
2008: Peter I Boross; P L E M van Lent; Javier Martin-Ramirez; Jos van der Kaa; Melissa H C M Mulder; Jill W C Claassens; Wim B van den Berg; Victoria L Arandhara; Sjef Verbeek
Destructive arthritis in the absence of both FcgammaRI and FcgammaRIII.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):5083-91.
2007: Isabel Olivares; Alok Mulky; Peter I Boross; József Tözsér; John C Kappes; Cecilio López-Galíndez; Luis Menéndez-Arias
HIV-1 protease dimer interface mutations that compensate for viral reverse transcriptase instability in infectious virions.
Journal of molecular biology 2007;372(2):369-81.
2007: Yuan-Fang Wang; Yunfeng Tie; Peter I Boross; Jozsef Tozser; Arun K Ghosh; Robert W Harrison; Irene T Weber
Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.
Journal of medicinal chemistry 2007;50(18):4509-15.
2007: Tamás Sperka; Gabriella Miklóssy; Yunfeng Tie; Péter Bagossi; Gábor Zahuczky; Peter I Boross; Krisztina Matúz; Robert W Harrison; Irene T Weber; József Tözsér
Bovine leukemia virus protease: comparison with human T-lymphotropic virus and human immunodeficiency virus proteases.
The Journal of general virology 2007;88(Pt 7):2052-63.
2007: Masayuki Amano; yasuhiro koh; Debananda Das; Jianfeng Li; Sofiya Leschenko; Yuan-Fang Wang; Peter I Boross; Irene T Weber; Arun K Ghosh; Hiroaki Mitsuya
A novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro.
Antimicrobial agents and chemotherapy 2007;51(6):2143-55.
2007: Yunfeng Tie; Andrey Yu Kovalevsky; Peter I Boross; Yuan-Fang Wang; Arun K Ghosh; Jozsef Tozser; Robert W Harrison; Irene T Weber
Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir.
Proteins 2007;67(1):232-42.
2006: Peter I Boross; Sjef Verbeek
The complex role of Fcgamma receptors in the pathology of arthritis.
Springer seminars in immunopathology 2006;28(4):339-50.
2006: Hazel Uppington; Nathalie Menager; Peter I Boross; James Wood; Mark Sheppard; Sjef Verbeek; Pietro Mastroeni
Effect of immune serum and role of individual Fcgamma receptors on the intracellular distribution and survival of Salmonella enterica serovar Typhimurium in murine macrophages.
Immunology 2006;119(2):147-58.
2006: Tamás Sperka; Peter I Boross; Helga Eizert; József Tözsér; Péter Bagossi
Effect of mutations on the dimer stability and the pH optimum of the human foamy virus protease.
Protein engineering, design & selection : PEDS 2006;19(8):369-75.
2006: Bin Fang; Peter I Boross; Jozsef Tozser; Irene T Weber
Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition.
Journal of molecular biology 2006;360(3):654-66.
2006: Fengling Liu; Andrey Yu Kovalevsky; John M Louis; Peter I Boross; Yuan-Fang Wang; Robert W Harrison; Irene T Weber
Mechanism of drug resistance revealed by the crystal structure of the unliganded HIV-1 protease with F53L mutation.
Journal of molecular biology 2006;358(5):1191-9.
2006: Anita Fehér; Peter I Boross; Tamás Sperka; Gabriella Miklóssy; János Kádas; Péter Bagossi; Stephen Oroszlan; Irene T Weber; József Tözsér
Characterization of the murine leukemia virus protease and its comparison with the human immunodeficiency virus type 1 protease.
The Journal of general virology 2006;87(Pt 5):1321-30.
2006: Peter I Boross; József Tözsér; Péter Bagossi
Improved purification protocol for wild-type and mutant human foamy virus proteases.
Protein expression and purification 2006;46(2):343-7.
2006: Andrey Yu Kovalevsky; Yunfeng Tie; Fengling Liu; Peter I Boross; Yuan-Fang Wang; Sofiya Leshchenko; Arun K Ghosh; Robert W Harrison; Irene T Weber
Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M.
Journal of medicinal chemistry 2006;49(4):1379-87.
2005: Fengling Liu; Peter I Boross; Yuan-Fang Wang; Jozsef Tozser; John M Louis; Robert W Harrison; Irene T Weber
Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
Journal of molecular biology 2005;354(4):789-800.
2005: Yunfeng Tie; Peter I Boross; Yuan-Fang Wang; Laquasha Gaddis; Fengling Liu; Xianfeng Chen; Jozsef Tozser; Robert W Harrison; Irene T Weber
Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
The FEBS journal 2005;272(20):5265-77.
2005: Péter Bagossi; Tamás Sperka; Anita Fehér; János Kádas; Gábor Zahuczky; Gabriella Miklóssy; Peter I Boross; József Tözsér
Amino acid preferences for a critical substrate binding subsite of retroviral proteases in type 1 cleavage sites.
Journal of virology 2005;79(7):4213-8.
2005: K C A M Nabbe; Peter I Boross; A E M Holthuysen; A W Sloëtjes; Jay K Kolls; Sjef Verbeek; P L E M van Lent; Wim B van den Berg
Joint inflammation and chondrocyte death become independent of Fcgamma receptor type III by local overexpression of interferon-gamma during immune complex-mediated arthritis.
Arthritis and rheumatism 2005;52(3):967-74.
2005: Marcy L Vana; Aiping Chen; Peter I Boross; Irene T Weber; Dalbinder Colman; Eric Barklis; Jonathan Leis
Mutations affecting cleavage at the p10-capsid protease cleavage site block Rous sarcoma virus replication.
Retrovirology 2005;2():58.
2004: Péter Bagossi; János Kádas; Gabriella Miklóssy; Peter I Boross; Irene T Weber; József Tözsér
Development of a microtiter plate fluorescent assay for inhibition studies on the HTLV-1 and HIV-1 proteinases.
Journal of virological methods 2004;119(2):87-93.
2004: János Kádas; Irene T Weber; Péter Bagossi; Gabriella Miklóssy; Peter I Boross; Stephen Oroszlan; József Tözsér
Narrow substrate specificity and sensitivity toward ligand-binding site mutations of human T-cell Leukemia virus type 1 protease.
The Journal of biological chemistry 2004;279(26):27148-57.
2004: Anita Fehér; Peter I Boross; Tamás Sperka; Stephen Oroszlan; József Tözsér
Expression of the murine leukemia virus protease in fusion with maltose-binding protein in Escherichia coli.
Protein expression and purification 2004;35(1):62-8.
2004: Yunfeng Tie; Peter I Boross; Yuan-Fang Wang; Laquasha Gaddis; Azhar K Hussain; Sofiya Leshchenko; Arun K Ghosh; John M Louis; Robert W Harrison; Irene T Weber
High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains.
Journal of molecular biology 2004;338(2):341-52.
2004: Bhuvaneshwari Mahalingam; Yuan-Fang Wang; Peter I Boross; Jozsef Tozser; John M Louis; Robert W Harrison; Irene T Weber
Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site.
European journal of biochemistry / FEBS 2004;271(8):1516-24.
2003: P L E M van Lent; K C A M Nabbe; Peter I Boross; Arjen B Blom; Johannes Roth; A E M Holthuysen; Annet Sloetjes; Sjef Verbeek; Wim B van den Berg
The inhibitory receptor FcgammaRII reduces joint inflammation and destruction in experimental immune complex-mediated arthritides not only by inhibition of FcgammaRI/III but also by efficient clearance and endocytosis of immune complexes.
The American journal of pathology 2003;163(5):1839-48.
2003: yasuhiro koh; Hirotomo Nakata; Kenji Maeda; Hiromi Ogata; Geoffrey Bilcer; Thippeswamy Devasamudram; John F Kincaid; Peter I Boross; Yuan-Fang Wang; Yunfeng Tie; Patra Volarath; Laquasha Gaddis; Robert W Harrison; Irene T Weber; Arun K Ghosh; Hiroaki Mitsuya
Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.
Antimicrobial agents and chemotherapy 2003;47(10):3123-9.
2003: József Tözsér; Sergey Shulenin; János Kádas; Peter I Boross; Péter Bagossi; Terry D Copeland; Bala C Nair; Mangalasseril G Sarngadharan; Stephen Oroszlan
Human immunodeficiency virus type 1 capsid protein is a substrate of the retroviral proteinase while integrase is resistant toward proteolysis.
Virology 2003;310(1):16-23.
2003: K C A M Nabbe; Arjen B Blom; A E M Holthuysen; Peter I Boross; Johannes Roth; Sjef Verbeek; P L E M van Lent; Wim B van den Berg
Coordinate expression of activating Fc gamma receptors I and III and inhibiting Fc gamma receptor type II in the determination of joint inflammation and cartilage destruction during immune complex-mediated arthritis.
Arthritis and rheumatism 2003;48(1):255-65.
2002: Anita Fehér; Irene T Weber; Péter Bagossi; Peter I Boross; Bhuvaneshwari Mahalingam; John M Louis; Terry D Copeland; Ivan Y Torshin; Robert W Harrison; József Tözsér
Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites.
European journal of biochemistry / FEBS 2002;269(16):4114-20.
2002: Bhuvaneshwari Mahalingam; Peter I Boross; Yuan-Fang Wang; John M Louis; Christopher C Fischer; Jozsef Tozser; Robert W Harrison; Irene T Weber
Combining mutations in HIV-1 protease to understand mechanisms of resistance.
Proteins 2002;48(1):107-16.
2000: Gábor Zahuczky; Peter I Boross; Péter Bagossi; G Emri; Terry D Copeland; Stephen Oroszlan; John M Louis; József Tözsér
Cloning of the bovine leukemia virus proteinase in Escherichia coli and comparison of its specificity to that of human T-cell leukemia virus proteinase.
Biochimica et biophysica acta 2000;1478(1):1-8.
1999: G Fenyöfalvi; Péter Bagossi; Terry D Copeland; Stephen Oroszlan; Peter I Boross; József Tözsér
Expression and characterization of human foamy virus proteinase.
FEBS letters 1999;462(3):397-401.
1999: József Tözsér; Péter Bagossi; Peter I Boross; John M Louis; Eva Majerova; Stephen Oroszlan; Terry D Copeland
Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates.
European journal of biochemistry / FEBS 1999;265(1):423-9.
1999: Peter I Boross; Péter Bagossi; Terry D Copeland; Stephen Oroszlan; John M Louis; József Tözsér
Effect of substrate residues on the P2' preference of retroviral proteinases.
European journal of biochemistry / FEBS 1999;264(3):921-9.
1997: Zoltán Nemes; Róza Adány; Margit Balázs; Peter I Boross; László Fésüs
Identification of cytoplasmic actin as an abundant glutaminyl substrate for tissue transglutaminase in HL-60 and U937 cells undergoing apoptosis.
The Journal of biological chemistry 1997;272(33):20577-83.
1996: M S Bogáti; István Pócsi; J Maticsek; Peter I Boross; József Tözsér; Attila Szentirmai
NADP-specific glutamate dehydrogenase of Penicillium chrysogenum has a homohexamer structure.
Journal of basic microbiology 1996;36(5):371-5.