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Thresia Thomas

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Amanda Beck; Thresia Thomas; Veena Vijayanathan; Thekkumkat John Thomas
Ionic microenvironmental effects on triplex DNA stabilization: Cationic counterion effects on poly(dT)·poly(dA)·poly(dT).
Irina Nayvelt; Rajesh Patel; Akira Shirahata; Thresia Thomas; Leena Alhonen; Gokul Das; Hui-Chen Hsu; Mervi T Hyvönen; Shali John; Tuomo A Keinänen; Wensheng Liu; Pingar Yang; T J Thomas
A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells.
Alex M Chen; Oleh Taratula; Dongguang Wei; Hsin-I Yen; Thresia Thomas; T J Thomas; Tamara Minko; Huixin He
Labile catalytic packaging of DNA/siRNA: control of gold nanoparticles "out" of DNA/siRNA complexes.

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2013: Amanda Beck; Thresia Thomas; Veena Vijayanathan; Thekkumkat John Thomas
Ionic microenvironmental effects on triplex DNA stabilization: Cationic counterion effects on poly(dT)·poly(dA)·poly(dT).
Biochimie 2013;95(6):1310-8.
2012: Irina Nayvelt; Rajesh Patel; Akira Shirahata; Thresia Thomas; Leena Alhonen; Gokul Das; Hui-Chen Hsu; Mervi T Hyvönen; Shali John; Tuomo A Keinänen; Wensheng Liu; Pingar Yang; T J Thomas
A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells.
Amino acids 2012;42(2-3):899-911.
2010: Alex M Chen; Oleh Taratula; Dongguang Wei; Hsin-I Yen; Thresia Thomas; T J Thomas; Tamara Minko; Huixin He
Labile catalytic packaging of DNA/siRNA: control of gold nanoparticles "out" of DNA/siRNA complexes.
ACS nano 2010;4(7):3679-88.
2010: Irina Nayvelt; Mervi T Hyvönen; Leena Alhonen; Ipsit Pandya; Thresia Thomas; Alex R Khomutov; Jouko Vepsäläinen; Rajesh Patel; Tuomo A Keinänen; Thekkumkat John Thomas
DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage.
Biomacromolecules 2010;11(1):97-105.
2008: Shali John; Irina Nayvelt; Hui-Chen Hsu; Pingar Yang; Wensheng Liu; Gokul M Das; Thresia Thomas; Thekkumkat John Thomas
Regulation of estrogenic effects by beclin 1 in breast cancer cells.
Cancer research 2008;68(19):7855-63.
2008: Neethu Sundaresan; Cherumuttathu H Suresh; Thresia Thomas; T J Thomas; C K S Pillai
Liquid crystalline phase behavior of high molecular weight DNA: a comparative study of the influence of metal ions of different size, charge and binding mode.
Biomacromolecules 2008;9(7):1860-9.
2007: Sandhya K Nair; Arti Verma; Thekkumkat John Thomas; T C Chou; Michael A Gallo; Akira Shirahata; Thresia Thomas
Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine.
Cancer letters 2007;250(2):311-22.
2007: Veena Vijayanathan; Norma J Greenfield; Thekkumkat John Thomas; Margarita Ivanova; Valentyn V Tyulmenkov; Carolyn M Klinge; Michael A Gallo; Thresia Thomas
Effects of estradiol and 4-hydroxytamoxifen on the conformation, thermal stability, and DNA recognition of estrogen receptor beta.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2007;85(1):1-10.
2007: Irina Nayvelt; Thresia Thomas; T J Thomas
Mechanistic differences in DNA nanoparticle formation in the presence of oligolysines and poly-L-lysine.
Biomacromolecules 2007;8(2):477-84.
2006: Veena Vijayanathan; Sripriya Venkiteswaran; Sandhya K Nair; Arti Verma; Thekkumkat John Thomas; Bao Ting Zhu; Thresia Thomas
Physiologic levels of 2-methoxyestradiol interfere with nongenomic signaling of 17beta-estradiol in human breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(7 Pt 1):2038-48.
2006: Neethu Sundaresan; Thresia Thomas; Thekkumkat John Thomas; Chennakkattu Krishna Sadasivan Pillai; Chennakkatu Krishna Saolashiuan Pillai
Lithium ion induced stabilization of the liquid crystalline DNA.
Macromolecular bioscience 2006;6(1):27-32.
2006: Veena Vijayanathan; Thekkumkat John Thomas; Sandhya K Nair; Akira Shirahata; Michael A Gallo; Thresia Thomas
Bending of the estrogen response element by polyamines and estrogen receptors alpha and beta: a fluorescence resonance energy transfer study.
The international journal of biochemistry & cell biology 2006;38(7):1191-1206.
2005: Sandhya K Nair; Thekkumkat John Thomas; Norma J Greenfield; A Chen; H He; Thresia Thomas
Conformational dynamics of estrogen receptors alpha and beta as revealed by intrinsic tryptophan fluorescence and circular dichroism.
Journal of molecular endocrinology 2005;35(2):211-23.
2005: Veena Vijayanathan; Jasleen Lyall; Thresia Thomas; Akira Shirahata; Thekkumkat John Thomas
Ionic, structural, and temperature effects on DNA nanoparticles formed by natural and synthetic polyamines.
Biomacromolecules 2005;6(2):1097-103.
2005: Joan S Lewis; Thekkumkat John Thomas; Richard G Pestell; Chris Albanese; Michael A Gallo; Thresia Thomas
Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells.
Journal of molecular endocrinology 2005;34(1):91-105.
2005: Sripriya Venkiteswaran; Veena Vijayanathan; Akira Shirahata; Thresia Thomas; Thekkumkat John Thomas
Antisense recognition of the HER-2 mRNA: effects of phosphorothioate substitution and polyamines on DNA.RNA, RNA.RNA, and DNA.DNA duplex stability.
Biochemistry 2005;44(1):303-12.
2005: Joan S Lewis; Veena Vijayanathan; Thekkumkat John Thomas; Richard G Pestell; Chris Albanese; Michael A Gallo; Thresia Thomas
Activation of cyclin D1 by estradiol and spermine in MCF-7 breast cancer cells: a mechanism involving the p38 MAP kinase and phosphorylation of ATF-2.
Oncology research 2005;15(3):113-28.
2005: Srivani Balabhadrapathruni; Latha M Santhakumaran; Thekkumkat John Thomas; Akira Shirahata; Michael A Gallo; Thresia Thomas
Bis(ethyl)norspermine potentiates the apoptotic activity of the pure antiestrogen ICI 182780 in breast cancer cells.
Oncology reports 2005;13(1):101-8.
2004: Thresia Thomas; Michael A Gallo; T J Thomas
Estrogen receptors as targets for drug development for breast cancer, osteoporosis and cardiovascular diseases.
Current cancer drug targets 2004;4(6):483-99.
2004: Latha M Santhakumaran; Thresia Thomas; Thekkumkat John Thomas
Enhanced cellular uptake of a triplex-forming oligonucleotide by nanoparticle formation in the presence of polypropylenimine dendrimers.
Nucleic acids research 2004;32(7):2102-12.
2004: Veena Vijayanathan; Thresia Thomas; Thomas Antony; Akira Shirahata; Thekkumkat John Thomas
Formation of DNA nanoparticles in the presence of novel polyamine analogues: a laser light scattering and atomic force microscopic study.
Nucleic acids research 2004;32(1):127-34.
2003: Thresia Thomas; Thekkumkat John Thomas
Polyamine metabolism and cancer.
Journal of cellular and molecular medicine 2003;7(2):113-26.
2002: Veena Vijayanathan; Thresia Thomas; Thekkumkat John Thomas
DNA nanoparticles and development of DNA delivery vehicles for gene therapy.
Biochemistry 2002;41(48):14085-94.
2002: Francisco Javier Ramírez; Thekkumkat John Thomas; Thomas Antony; J Ruiz-Chica; Thresia Thomas
Effects of aminooxy analogues of biogenic polyamines on aggregation and stability of calf thymus DNA.
Biopolymers 2002;65(2):148-57.
2002: M Saminathan; Thresia Thomas; Akira Shirahata; C K S Pillai; Thekkumkat John Thomas
Polyamine structural effects on the induction and stabilization of liquid crystalline DNA: potential applications to DNA packaging, gene therapy and polyamine therapeutics.
Nucleic acids research 2002;30(17):3722-31.
2002: Veena Vijayanathan; Thresia Thomas; Leonard H Sigal; Thekkumkat John Thomas
Direct measurement of the association constant of HER2/neu antisense oligonucleotide to its target RNA sequence using a molecular beacon.
Antisense & nucleic acid drug development 2002;12(4):225-33.
2002: Thresia Thomas; Srivani Balabhadrapathruni; Michael A Gallo; Thekkumkat John Thomas
Development of polyamine analogs as cancer therapeutic agents.
Oncology research 2002;13(3):123-35.
2001: Joan S Lewis; Thekkumkat John Thomas; Carolyn M Klinge; Michael A Gallo; Thresia Thomas
Regulation of cell cycle and cyclins by 16alpha-hydroxyestrone in MCF-7 breast cancer cells.
Journal of molecular endocrinology 2001;27(3):293-307.
2001: Veena Vijayanathan; Thresia Thomas; Akira Shirahata; Thekkumkat John Thomas
DNA condensation by polyamines: a laser light scattering study of structural effects.
Biochemistry 2001;40(45):13644-51.
2001: Thomas Antony; Thresia Thomas; Leonard H Sigal; Akira Shirahata; Thekkumkat John Thomas
A molecular beacon strategy for the thermodynamic characterization of triplex DNA: triplex formation at the promoter region of cyclin D1.
Biochemistry 2001;40(31):9387-95.
2001: Norma J Greenfield; Veena Vijayanathan; Thekkumkat John Thomas; Michael A Gallo; Thresia Thomas
Increase in the stability and helical content of estrogen receptor alpha in the presence of the estrogen response element: analysis by circular dichroism spectroscopy.
Biochemistry 2001;40(22):6646-52.
2001: N Shah; Thekkumkat John Thomas; Joan S Lewis; Carolyn M Klinge; Akira Shirahata; C Gelinas; Thresia Thomas
Regulation of estrogenic and nuclear factor kappa B functions by polyamines and their role in polyamine analog-induced apoptosis of breast cancer cells.
Oncogene 2001;20(14):1715-29.
2001: Thresia Thomas; Thekkumkat John Thomas
Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications.
Cellular and molecular life sciences : CMLS 2001;58(2):244-58.
2000: Joan S Lewis; Thekkumkat John Thomas; Akira Shirahata; Thresia Thomas
Self-assembly of an oligodeoxyribonucleotide harboring the estrogen response element in the presence of polyamines: ionic, structural, and DNA sequence specificity effects.
Biomacromolecules 2000;1(3):339-49.
2000: CA Faaland; Thekkumkat John Thomas; Srivani Balabhadrapathruni; T Langer; S Mian; Akira Shirahata; Michael A Gallo; Thresia Thomas
Molecular correlates of the action of bis(ethyl)polyamines in breast cancer cell growth inhibition and apoptosis.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2000;78(4):415-26.
2000: Srivani Balabhadrapathruni; Thekkumkat John Thomas; EJ Yurkow; Peter S Amenta; Thresia Thomas
Effects of genistein and structurally related phytoestrogens on cell cycle kinetics and apoptosis in MDA-MB-468 human breast cancer cells.
Oncology reports 2000;7(1):3-12.
1999: N Shah; Thresia Thomas; Akira Shirahata; Leonard H Sigal; Thekkumkat John Thomas
Activation of nuclear factor kappaB by polyamines in breast cancer cells.
Biochemistry 1999;38(45):14763-74.
1999: N Shah; Thomas Antony; S Haddad; Peter S Amenta; Akira Shirahata; Thekkumkat John Thomas; Thresia Thomas
Antitumor effects of bis(ethyl)polyamine analogs on mammary tumor development in FVB/NTgN (MMTVneu) transgenic mice.
Cancer letters 1999;146(1):15-23.
1999: R M Thomas; Thresia Thomas; M Wada; Leonard H Sigal; Akira Shirahata; Thekkumkat John Thomas
Facilitation of the cellular uptake of a triplex-forming oligonucleotide by novel polyamine analogues: structure-activity relationships.
Biochemistry 1999;38(40):13328-37.
1999: Thomas Antony; Thresia Thomas; Akira Shirahata; Thekkumkat John Thomas
Selectivity of polyamines on the stability of RNA-DNA hybrids containing phosphodiester and phosphorothioate oligodeoxyribonucleotides.
Biochemistry 1999;38(33):10775-84.
1999: Thresia Thomas; Srivani Balabhadrapathruni; Carol R Gardner; J Hong; CA Faaland; Thekkumkat John Thomas
Effects of epidermal growth factor on MDA-MB-468 breast cancer cells: alterations in polyamine biosynthesis and the expression of p21/CIP1/WAF1.
Journal of cellular physiology 1999;179(3):257-66.
1999: Thomas Antony; Thresia Thomas; Akira Shirahata; Leonard H Sigal; Thekkumkat John Thomas
Selectivity of spermine homologs on triplex DNA stabilization.
Antisense & nucleic acid drug development 1999;9(2):221-31.
1999: Thresia Thomas; N Shah; Carolyn M Klinge; CA Faaland; S Adihkarakunnathu; Michael A Gallo; Thekkumkat John Thomas
Polyamine biosynthesis inhibitors alter protein-protein interactions involving estrogen receptor in MCF-7 breast cancer cells.
Journal of molecular endocrinology 1999;22(2):131-9.
1999: M Saminathan; Thomas Antony; Akira Shirahata; Leonard H Sigal; Thresia Thomas; Thekkumkat John Thomas
Ionic and structural specificity effects of natural and synthetic polyamines on the aggregation and resolubilization of single-, double-, and triple-stranded DNA.
Biochemistry 1999;38(12):3821-30.
1999: Thomas Antony; M Musso; M W Hosseini; G Brand; Norma J Greenfield; Thresia Thomas; Michael W Van Dyke; Thekkumkat John Thomas
Differential effects of cyclopolyamines on the stability and conformation of triplex DNA.
Antisense & nucleic acid drug development 1999;9(1):13-23.
1999: H C Hsu; Thresia Thomas; Leonard H Sigal; Thekkumkat John Thomas
Polyamine-fas interactions: inhibition of polyamine biosynthesis in MRL-lpr/lpr mice is associated with the up-regulation of fas mRNA in thymocytes.
Autoimmunity 1999;29(4):299-309.
1998: J Hong; N N Shah; Thekkumkat John Thomas; Michael A Gallo; EJ Yurkow; Thresia Thomas
Differential effects of estradiol and its analogs on cyclin D1 and CDK4 expression in estrogen receptor positive MCF-7 and estrogen receptor-transfected MCF-10AEwt5 cells.
Oncology reports 1998;5(5):1025-33.
1998: Thekkumkat John Thomas; CA Faaland; S Adhikarakunnathu; L F Watkins; Thresia Thomas
Induction of p21 (CIP1/WAF1/SID1) by estradiol in a breast epithelial cell line transfected with the recombinant estrogen receptor gene: a possible mechanism for a negative regulatory role of estradiol.
Breast cancer research and treatment 1998;47(2):181-93.
1997: Thresia Thomas; G D Kulkarni; Michael A Gallo; Norma J Greenfield; Joan S Lewis; Akira Shirahata; Thekkumkat John Thomas
Effects of natural and synthetic polyamines on the conformation of an oligodeoxyribonucleotide with the estrogen response element.
Nucleic acids research 1997;25(12):2396-402.
1997: CA Faaland; S Adhikarakunnathu; Thresia Thomas; Thekkumkat John Thomas
Mechanism of action of a tyrphostin, 3,4-dihydroxy-alpha-cyanothiocinnamamide, in breast cancer cell growth inhibition involves the suppression of cyclin B1 and the functional activity of cyclin B1/p34cdc2 complex.
Breast cancer research and treatment 1997;44(1):47-56.
1997: M Musso; Thresia Thomas; A Shirahata; Leonard Sigal; Michael W Van Dyke; Thekkumkat John Thomas
Effects of chain length modification and bis(ethyl) substitution of spermine analogs on purine-purine-pyrimidine triplex DNA stabilization, aggregation, and conformational transitions.
Biochemistry 1997;36(6):1441-9.
1997: Thekkumkat John Thomas; C Ashley; Thresia Thomas; Akira Shirahata; Leonard H Sigal; J S Lee
Pyrimidine-purine-pyrimidine triplex DNA stabilization in the presence of tetramine and pentamine analogues of spermine.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1997;75(3):207-15.
1996: Thekkumkat John Thomas; G D Kulkarni; Norma J Greenfield; Akira Shirahata; Thresia Thomas
Structural specificity effects of trivalent polyamine analogues on the stabilization and conformational plasticity of triplex DNA.
The Biochemical journal 1996;319 ( Pt 2)():591-9.
1996: Thresia Thomas; CA Faaland; S Adhikarakunnathu; Thekkumkat John Thomas
Structure-activity relations of S-adenosylmethionine decarboxylase inhibitors on the growth of MCF-7 breast cancer cells.
Breast cancer research and treatment 1996;39(3):293-306.
1995: Thekkumkat John Thomas; U B Gunnia; James R Seibold; Thresia Thomas
Defective signal-transduction pathways in T-cells from autoimmune MRL-lpr/lpr mice are associated with increased polyamine concentrations.
The Biochemical journal 1995;311 ( Pt 1)():175-82.
1995: Thekkumkat John Thomas; CA Faaland; Michael A Gallo; Thresia Thomas
Suppression of c-myc oncogene expression by a polyamine-complexed triplex forming oligonucleotide in MCF-7 breast cancer cells.
Nucleic acids research 1995;23(17):3594-9.
1995: Thresia Thomas; Michael A Gallo; C M Klinge; Thekkumkat John Thomas
Polyamine-mediated conformational perturbations in DNA alter the binding of estrogen receptor to poly(dG-m5dC).poly(dG-m5dC) and a plasmid containing the estrogen response element.
The Journal of steroid biochemistry and molecular biology 1995;54(3-4):89-99.
1994: Thresia Thomas; Michael A Gallo
Polyamine-induced changes in the sedimentation profile and DNA binding of aryl hydrocarbon receptor.
Toxicology letters 1994;74(1):35-49.
1994: Thekkumkat John Thomas; Thresia Thomas
Polyamine-induced Z-DNA conformation in plasmids containing (dA-dC)n.(dG-dT)n inserts and increased binding of lupus autoantibodies to the Z-DNA form of plasmids.
The Biochemical journal 1994;298 ( Pt 2)():485-91.
1994: Thresia Thomas; Thekkumkat John Thomas
Regulation of cyclin B1 by estradiol and polyamines in MCF-7 breast cancer cells.
Cancer research 1994;54(4):1077-84.
1994: Thresia Thomas; Thekkumkat John Thomas
Estradiol control of ornithine decarboxylase mRNA, enzyme activity, and polyamine levels in MCF-7 breast cancer cells: therapeutic implications.
Breast cancer research and treatment 1994;29(2):189-201.
1993: Thresia Thomas; Thekkumkat John Thomas
Selectivity of polyamines in triplex DNA stabilization.
Biochemistry 1993;32(50):14068-74.
1993: Thresia Thomas; U B Gunnia; EJ Yurkow; James R Seibold; Thekkumkat John Thomas
Inhibition of calcium signalling in murine splenocytes by polyamines: differential effects on CD4 and CD8 T-cells.
The Biochemical journal 1993;291 ( Pt 2)():375-81.
1993: H C Hsu; Thresia Thomas; James R Seibold; Thekkumkat John Thomas
Studies on the effects of an ornithine decarboxylase inhibitor on lupus nephritis reveal a post-transcriptional modification of the enzyme.
Agents and actions 1993;39 Spec No():C204-6.
1993: Thresia Thomas; Thekkumkat John Thomas
Structural specificity of polyamines in modulating the binding of estrogen receptor to potential Z-DNA forming sequences.
Journal of receptor research 1993;13(8):1115-33.
1992: S A MacKenzie; Thresia Thomas; T H Umbreit; Michael A Gallo
The potentiation of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity by tamoxifen in female CD1 mice.
Toxicology and applied pharmacology 1992;116(1):101-9.
1992: M J DeVito; Thresia Thomas; E Martin; T H Umbreit; Michael A Gallo
Antiestrogenic action of 2,3,7,8-tetrachlorodibenzo-p-dioxin: tissue-specific regulation of estrogen receptor in CD1 mice.
Toxicology and applied pharmacology 1992;113(2):284-92.
1992: M J DeVito; Thresia Thomas; T H Umbreit; Michael A Gallo
Multi-site regulation of estrogen receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Progress in clinical and biological research 1992;374():321-36.
1992: Thekkumkat John Thomas; U B Gunnia; Thresia Thomas
Reversal of the abnormal development of T cell subpopulations in the thymus of autoimmune MRL-lpr/lpr mice by a polyamine biosynthesis inhibitor.
Autoimmunity 1992;13(4):275-83.
1991: Thresia Thomas; D T Kiang; O A Jänne; Thekkumkat John Thomas
Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells.
Breast cancer research and treatment 1991;19(3):257-67.
1991: C C Chao; Thekkumkat John Thomas; P Ebede; Michael A Gallo; Thresia Thomas
Ionic and ligand-specific effects on the DNA binding of progesterone receptor bound to the synthetic progestin R5020 and the antiprogestin RU486.
Cancer research 1991;51(15):3938-45.
1991: U B Gunnia; Thresia Thomas; Thekkumkat John Thomas
The effects of polyamines on the immunogenicity of polynucleotides.
Immunological investigations 1991;20(4):337-50.
1991: Thekkumkat John Thomas; U B Gunnia; Thresia Thomas
Polyamine-induced B-DNA to Z-DNA conformational transition of a plasmid DNA with (dG-dC)n insert.
The Journal of biological chemistry 1991;266(10):6137-41.
1991: Thresia Thomas; U B Gunnia; James R Seibold; Thekkumkat John Thomas
Restoration of the DNA binding activity of estrogen receptor in MRL-lpr/lpr mice by a polyamine biosynthesis inhibitor.
Arthritis and rheumatism 1991;34(1):55-62.
1990: Thresia Thomas; S A MacKenzie; Michael A Gallo
Regulation of polyamine biosynthesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Toxicology letters 1990;53(3):315-25.
1990: Thekkumkat John Thomas; Thresia Thomas
Conformational transitions of polynucleotides in the presence of rhodium complexes.
Journal of biomolecular structure & dynamics 1990;7(6):1221-35.
1989: Thresia Thomas; B Trend; J R Butterfield; O A Jänne; D T Kiang
Regulation of ornithine decarboxylase gene expression in MCF-7 breast cancer cells by antiestrogens.
Cancer research 1989;49(21):5852-7.
1989: Thresia Thomas; Thekkumkat John Thomas
High affinity binding of estrogen receptor to recombinant plasmids containing (dA-dC)n.(dG-dT)n sequences.
Cancer research 1989;49(17):4734-9.
1989: Thekkumkat John Thomas; Thresia Thomas
Direct evidence for the presence of left-handed conformation in a supramolecular assembly of polynucleotides.
Nucleic acids research 1989;17(10):3795-810.