FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

David Thompson

Research Profile

Living Beings

Procedures

Ovariectomy

Concepts & Ideas

Bone Density

Physiology

Chemicals & Drugs

Anatomy

Disorders

Co-author Network

Publications

TOP 3
Kimberly O Cameron; Bruce A Lefker; Hua Zhu Ke; Mei Li; Michael P Zawistoski; Christina M Tjoa; Ann S Wright; Shari L DeNinno; Vishwas M Paralkar; Thomas A Owen; Li Yu; David D Thompson
Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation.
K K Terry; W S Lebel; K A Riccardi; William A Grasser; David D Thompson; Vishwas M Paralkar
Effects of gestational age on prostaglandin EP receptor expression and functional involvement during in vitro contraction of the guinea pig uterus.
M Li; David D Thompson; Vishwas M Paralkar
Prostaglandin E(2) receptors in bone formation.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of David Thompson (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2009: Kimberly O Cameron; Bruce A Lefker; Hua Zhu Ke; Mei Li; Michael P Zawistoski; Christina M Tjoa; Ann S Wright; Shari L DeNinno; Vishwas M Paralkar; Thomas A Owen; Li Yu; David D Thompson
Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation.
Bioorganic & medicinal chemistry letters 2009;19(7):2075-8.
2008: K K Terry; W S Lebel; K A Riccardi; William A Grasser; David D Thompson; Vishwas M Paralkar
Effects of gestational age on prostaglandin EP receptor expression and functional involvement during in vitro contraction of the guinea pig uterus.
Prostaglandins, leukotrienes, and essential fatty acids 2008;78(1):3-10.
2007: M Li; David D Thompson; Vishwas M Paralkar
Prostaglandin E(2) receptors in bone formation.
International orthopaedics 2007;31(6):767-72.
2006: Slobodan Vukicevic; Petra Simic; Fran Borovecki; Lovorka Grgurevic; Dunja Rogic; Iva Orlic; William A Grasser; David D Thompson; Vishwas M Paralkar
Role of EP2 and EP4 receptor-selective agonists of prostaglandin E(2) in acute and chronic kidney failure.
Kidney international 2006;70(6):1099-106.
2006: Xiao-Ning Wang; Hollis A Simmons; Christopher T Salatto; Patricia G Cosgrove; David D Thompson
Lasofoxifene enhances vaginal mucus formation without causing hypertrophy and increases estrogen receptor beta and androgen receptor in rats.
Menopause (New York, N.Y.) 2006;13(4):609-20.
2006: Hua Zhu Ke; D Todd Crawford; Hong Qi; Hollis A Simmons; Thomas A Owen; Vishwas M Paralkar; Mei Li; Bihong Lu; William A Grasser; Kimberly O Cameron; Bruce A Lefker; Paul DaSilva-Jardine; Dennis O Scott; Qing Zhang; Xiao Yan Tian; Webster S S Jee; Thomas Brown; David D Thompson
A nonprostanoid EP4 receptor selective prostaglandin E2 agonist restores bone mass and strength in aged, ovariectomized rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(4):565-75.
2006: Kimberly O Cameron; Bruce A Lefker; Margaret Y Chu-Moyer; D Todd Crawford; Paul DaSilva Jardine; Shari L DeNinno; Sandra Gilbert; William A Grasser; HuaZhu Ke; Bihong Lu; Thomas A Owen; Vishwas M Paralkar; Hong Qi; Dennis O Scott; David D Thompson; Christina M Tjoa; Michael P Zawistoski
Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats.
Bioorganic & medicinal chemistry letters 2006;16(7):1799-802.
2005: Richard Chesworth; Matthew D Wessel; Lisa Heyden; F Michael Mangano; Michael P Zawistoski; Laura Gegnas; David Galluzzo; Bruce A Lefker; Kimberly O Cameron; Jeanne Tickner; Bihong Lu; Tessa A Castleberry; Donna N Petersen; Amy Brault; Pia Perry; Oicheng Ng; Thomas A Owen; Lydia Pan; Hua Zhu Ke; Thomas Brown; David D Thompson; Paul DaSilva-Jardine
Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands.
Bioorganic & medicinal chemistry letters 2005;15(24):5562-6.
2005: Hua Zhu Ke; X N Wang; J O'Malley; Bruce A Lefker; David D Thompson
Selective androgen receptor modulators--prospects for emerging therapy in osteoporosis?
Journal of musculoskeletal & neuronal interactions 2005;5(4):355.
2005: Hua Zhu Ke; Hong Qi; D Todd Crawford; Hollis A Simmons; Gang Xu; Mei Li; Lori A Plum; Margaret Clagett-Dame; Hector F Deluca; David D Thompson; Thomas Brown
A new vitamin D analog, 2MD, restores trabecular and cortical bone mass and strength in ovariectomized rats with established osteopenia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(10):1742-55.
2005: Mei Li; David R Healy; Yan Li; Hollis A Simmons; D Todd Crawford; Hua Zhu Ke; Lydia C Pan; Thomas Brown; David D Thompson
Osteopenia and impaired fracture healing in aged EP4 receptor knockout mice.
Bone 2005;37(1):46-54.
2004: Richard Chesworth; Michael P Zawistoski; Bruce A Lefker; Kimberly O Cameron; Robert F Day; F Michael Mangano; Robert L Rosati; Stacy Colella; Donna N Petersen; Amy Brault; Bihong Lu; Lydia C Pan; Pia Perry; Oicheng Ng; Tessa A Castleberry; Thomas A Owen; Thomas Brown; David D Thompson; Paul DaSilva-Jardine
Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists.
Bioorganic & medicinal chemistry letters 2004;14(11):2729-33.
2004: Hua Zhu Ke; George L Foley; Hollis A Simmons; Victor Shen; David D Thompson
Long-term treatment of lasofoxifene preserves bone mass and bone strength and does not adversely affect the uterus in ovariectomized rats.
Endocrinology 2004;145(4):1996-2005.
2004: Mei Li; David R Healy; Yan Li; Hollis A Simmons; M Su; Webster S S Jee; Victor Shen; David D Thompson
Alfacalcidol prevents age-related bone loss and causes an atypical pattern of bone formation in aged male rats.
Journal of musculoskeletal & neuronal interactions 2004;4(1):22-32.
2003: Mei Li; Hua Zhu Ke; Hong Qi; David R Healy; Yan Li; D Todd Crawford; Vishwas M Paralkar; Thomas A Owen; Kimberly O Cameron; Bruce A Lefker; Thomas Brown; David D Thompson
A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(11):2033-42.
2003: Hua Zhu Ke; Hong Qi; A Frederik Weidema; Qing Zhang; Nattapon Panupinthu; D Todd Crawford; William A Grasser; Vishwas M Paralkar; Mei Li; Laurent P Audoly; Christopher A Gabel; Webster S S Jee; S Jeffrey Dixon; Stephen M Sims; David D Thompson
Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption.
Molecular endocrinology (Baltimore, Md.) 2003;17(7):1356-67.
2003: Vishwas M Paralkar; Fran Borovecki; Hua Zhu Ke; Kimberly O Cameron; Bruce A Lefker; William A Grasser; Thomas A Owen; Mei Li; Paul DaSilva-Jardine; M Zhou; R L Dunn; F Dumont; R Korsmeyer; P Krasney; Thomas Brown; D Plowchalk; Slobodan Vukicevic; David D Thompson
An EP2 receptor-selective prostaglandin E2 agonist induces bone healing.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6736-40.
2003: William A Grasser; Amy P Baumann; Stephen F Petras; H James Harwood; R Devalaraja; Richard Renkiewicz; Vijay Baragi; David D Thompson; V M Paraklar
Regulation of osteoclast differentiation by statins.
Journal of musculoskeletal & neuronal interactions 2003;3(1):53-62.
2003: Mei Li; David R Healy; Hollis A Simmons; Hua Zhu Ke; David D Thompson
Alfacalcidol restores cancellous bone in ovariectomized rats.
Journal of musculoskeletal & neuronal interactions 2003;3(1):39-46.
2003: Philip A Carpino; Bruce A Lefker; Steven M Toler; Lydia C Pan; John R Hadcock; Ewell R Cook; Joseph N DiBrino; Anthony M Campeta; Shari L DeNinno; Kristin L Chidsey-Frink; William A Hada; John Inthavongsay; F Michael Mangano; Michelle A Mullins; David F Nickerson; Oicheng Ng; Christine M Pirie; John A Ragan; Colin R Rose; David A Tess; Ann S Wright; Li Yu; Michael P Zawistoski; Paul DaSilva-Jardine; Theresa C Wilson; David D Thompson
Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs). Discovery of capromorelin.
Bioorganic & medicinal chemistry 2003;11(4):581-90.
2002: Philip A Carpino; Bruce A Lefker; Steven M Toler; Lydia C Pan; John R Hadcock; Marianne C Murray; Ewell R Cook; Joseph N DiBrino; Shari L DeNinno; Kristin L Chidsey-Frink; William A Hada; John Inthavongsay; Sharon K Lewis; F Michael Mangano; Michelle A Mullins; David F Nickerson; Oicheng Ng; Christine M Pirie; John A Ragan; Colin R Rose; David A Tess; Ann S Wright; Li Yu; Michael P Zawistoski; John C Pettersen; Paul DaSilva-Jardine; Theresa C Wilson; David D Thompson
Discovery and biological characterization of capromorelin analogues with extended half-lives.
Bioorganic & medicinal chemistry letters 2002;12(22):3279-82.
2002: Hua Zhu Ke; Thomas Brown; Hong Qi; D Todd Crawford; Hollis A Simmons; Donna N Petersen; Melanie R Allen; John McNeish; David D Thompson
The role of estrogen receptor-beta, in the early age-related bone gain and later age-related bone loss in female mice.
Journal of musculoskeletal & neuronal interactions 2002;2(5):479-88.
2002: Vishwas M Paralkar; William A Grasser; Amy L Mansolf; Amy P Baumann; Thomas A Owen; Steven L Smock; Snjezana Martinovic; Fran Borovecki; Slobodan Vukicevic; Hua Zhu Ke; David D Thompson
Regulation of BMP-7 expression by retinoic acid and prostaglandin E(2).
Journal of cellular physiology 2002;190(2):207-17.
2001: Mei Li; David R Healy; Yan Li; Hollis A Simmons; F Gao; Hua Zhu Ke; B Lu; Thomas A Owen; David D Thompson
A comparison of the anabolic effects of rat and bovine parathyroid hormone (1-34) in ovariectomized rats.
Journal of musculoskeletal & neuronal interactions 2001;2(1):77-83.
2001: Hua Zhu Ke; Hong Qi; Kristin L Chidsey-Frink; D Todd Crawford; David D Thompson
Lasofoxifene (CP-336,156) protects against the age-related changes in bone mass, bone strength, and total serum cholesterol in intact aged male rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(4):765-73.
2001: Hua Zhu Ke; D Todd Crawford; Hong Qi; Kristin L Chidsey-Frink; Hollis A Simmons; Mei Li; Webster S S Jee; David D Thompson
Long-term effects of aging and orchidectomy on bone and body composition in rapidly growing male rats.
Journal of musculoskeletal & neuronal interactions 2001;1(3):215-24.
2001: Lydia C Pan; Philip A Carpino; Bruce A Lefker; John A Ragan; Steven M Toler; J C Pettersen; D O Nettleton; Oicheng Ng; Christine M Pirie; Kristin L Chidsey-Frink; Bihong Lu; David F Nickerson; David A Tess; Michelle A Mullins; D B MacLean; Paul DaSilva-Jardine; David D Thompson
Preclinical pharmacology of CP-424,391, an orally active pyrazolinone-piperidine [correction of pyrazolidinone-piperidine] growth hormone secretagogue.
Endocrine 2001;14(1):121-32.
2000: Hua Zhu Ke; Hong Qi; D Todd Crawford; Kristin L Chidsey-Frink; Hollis A Simmons; David D Thompson
Lasofoxifene (CP-336,156), a selective estrogen receptor modulator, prevents bone loss induced by aging and orchidectomy in the adult rat.
Endocrinology 2000;141(4):1338-44.
1999: Hua Zhu Ke; D Todd Crawford; Hong Qi; Christine M Pirie; Hollis A Simmons; Kristin L Chidsey-Frink; HK Chen; Webster S S Jee; David D Thompson
Droloxifene does not blunt bone anabolic effects of prostaglandin E2, but maintains prostaglandin E2-restored bone in aged, ovariectomized rats.
Bone 1999;24(1):41-7.
1998: Hua Zhu Ke; Victor Shen; Hong Qi; D Todd Crawford; DD Wu; XG Liang; Kristin L Chidsey-Frink; Christine M Pirie; Hollis A Simmons; David D Thompson
Prostaglandin E2 increases bone strength in intact rats and in ovariectomized rats with established osteopenia.
Bone 1998;23(3):249-55.
1998: Robert L Rosati; P Da Silva Jardine; Kimberly O Cameron; David D Thompson; Hua Zhu Ke; Steven M Toler; Thomas Brown; Lydia C Pan; C F Ebbinghaus; A R Reinhold; N C Elliott; B N Newhouse; C M Tjoa; P M Sweetnam; MJ Cole; M W Arriola; J W Gauthier; D Todd Crawford; David F Nickerson; Christine M Pirie; Hong Qi; Hollis A Simmons; George T Tkalcevic
Discovery and preclinical pharmacology of a novel, potent, nonsteroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthalene.
Journal of medicinal chemistry 1998;41(16):2928-31.
1998: Hollis A Simmons; Christine M Pirie; David D Thompson; Hua Zhu Ke
Parathyroid hormone (1-34) increased total body bone mass in aged female rats.
The Journal of pharmacology and experimental therapeutics 1998;286(1):341-4.
1998: Vishwas M Paralkar; A L Vail; William A Grasser; Thomas Brown; H Xu; Slobodan Vukicevic; Hua Zhu Ke; Hong Qi; Thomas A Owen; David D Thompson
Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family.
The Journal of biological chemistry 1998;273(22):13760-7.
1998: Hua Zhu Ke; Vishwas M Paralkar; William A Grasser; D Todd Crawford; Hong Qi; Hollis A Simmons; Christine M Pirie; Kristin L Chidsey-Frink; Thomas A Owen; Steven L Smock; HK Chen; Webster S S Jee; Kimberly O Cameron; Robert L Rosati; Thomas Brown; Paul DaSilva-Jardine; David D Thompson
Effects of CP-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models.
Endocrinology 1998;139(4):2068-76.
1998: R Rivera-Gonzalez; Donna N Petersen; George T Tkalcevic; David D Thompson; Thomas Brown
Estrogen-induced genes in the uterus of ovariectomized rats and their regulation by droloxifene and tamoxifen.
The Journal of steroid biochemistry and molecular biology 1998;64(1-2):13-24.
1997: William A Grasser; Lydia C Pan; David D Thompson; Vishwas M Paralkar
Common mechanism for the estrogen agonist and antagonist activities of droloxifene.
Journal of cellular biochemistry 1997;65(2):159-71.
1997: Hua Zhu Ke; HK Chen; Hollis A Simmons; Hong Qi; D Todd Crawford; Christine M Pirie; Kristin L Chidsey-Frink; YF Ma; Webster S S Jee; David D Thompson
Comparative effects of droloxifene, tamoxifen, and estrogen on bone, serum cholesterol, and uterine histology in the ovariectomized rat model.
Bone 1997;20(1):31-9.
1995: Hua Zhu Ke; H K Chen; Hong Qi; Christine M Pirie; Hollis A Simmons; YF Ma; Webster S S Jee; David D Thompson
Effects of droloxifene on prevention of cancellous bone loss and bone turnover in the axial skeleton of aged, ovariectomized rats.
Bone 1995;17(5):491-6.
1995: H K Chen; Hua Zhu Ke; C H Lin; YF Ma; Hong Qi; D Todd Crawford; Christine M Pirie; Hollis A Simmons; Webster S S Jee; David D Thompson
Droloxifene inhibits cortical bone turnover associated with estrogen deficiency in rats.
Bone 1995;17(4 Suppl):175S-179S.
1995: David D Thompson; Hollis A Simmons; Christine M Pirie; Hua Zhu Ke
FDA Guidelines and animal models for osteoporosis.
Bone 1995;17(4 Suppl):125S-133S.
1995: H K Chen; Hua Zhu Ke; Webster S S Jee; YF Ma; Christine M Pirie; Hollis A Simmons; David D Thompson
Droloxifene prevents ovariectomy-induced bone loss in tibiae and femora of aged female rats: a dual-energy X-ray absorptiometric and histomorphometric study.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995;10(8):1256-62.
1995: Hua Zhu Ke; Hollis A Simmons; Christine M Pirie; D Todd Crawford; David D Thompson
Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats.
Endocrinology 1995;136(6):2435-41.
1994: M A Thiede; Steven L Smock; D N Petersen; William A Grasser; David D Thompson; S K Nishimoto
Presence of messenger ribonucleic acid encoding osteocalcin, a marker of bone turnover, in bone marrow megakaryocytes and peripheral blood platelets.
Endocrinology 1994;135(3):929-37.
1993: L J Suva; J G Seedor; N Endo; H A Quartuccio; David D Thompson; I Bab; Gideon A Rodan
Pattern of gene expression following rat tibial marrow ablation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(3):379-88.
1992: David D Thompson; J G Seedor; H Quartuccio; H Solomon; C Fioravanti; J Davidson; H Klein; R Jackson; J Clair; D Frankenfield
The bisphosphonate, alendronate, prevents bone loss in ovariectomized baboons.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1992;7(8):951-60.
1991: M Sato; William A Grasser; N Endo; Robert Edward Akins; H Simmons; David D Thompson; E Golub; Gideon A Rodan
Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure.
The Journal of clinical investigation 1991;88(6):2095-105.
1991: Miron Weinreb; Gideon A Rodan; David D Thompson
Depression of osteoblastic activity in immobilized limbs of suckling rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1991;6(7):725-31.
1991: J G Seedor; H A Quartuccio; David D Thompson
The bisphosphonate alendronate (MK-217) inhibits bone loss due to ovariectomy in rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1991;6(4):339-46.
1991: Miron Weinreb; Gideon A Rodan; David D Thompson
Immobilization-related bone loss in the rat is increased by calcium deficiency.
Calcified tissue international 1991;48(2):93-100.
1991: David D Thompson; J G Seedor; William A Grasser; M Rosenblatt; Gideon A Rodan
Effect of alendronate (bisphosphonate) in animal models of hyperparathyroidism.
Contributions to nephrology 1991;91():134-9.
1990: David D Thompson; J G Seedor; Miron Weinreb; S Rosini; Gideon A Rodan
Aminohydroxybutane bisphosphonate inhibits bone loss due to immobilization in rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1990;5(3):279-86.
1990: M P Caulfield; R L McKee; M E Goldman; M A Thiede; David D Thompson; John E Fisher; J J Levy; J G Seedor; N Horiuchi; Thomas Landes Clemens
Parathyroid hormone-related protein (PTHrP): studies with synthetic peptides indicate that parathyroid hormone and PTHrP interact with the same receptor.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1990;17(7):633-7.
1989: Miron Weinreb; Gideon A Rodan; David D Thompson
Osteopenia in the immobilized rat hind limb is associated with increased bone resorption and decreased bone formation.
Bone 1989;10(3):187-94.
1988: David D Thompson; J G Seedor; John E Fisher; M Rosenblatt; Gideon A Rodan
Direct action of the parathyroid hormone-like human hypercalcemic factor on bone.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(15):5673-7.
1988: M Rosenblatt; M P Caulfield; John E Fisher; N Horiuchi; R L Mckee; Sevgi B Rodan; M A Thiede; David D Thompson; J G Seedor; R E Nutt
A tumor-secreted protein associated with human hypercalcemia of malignancy. Biology and molecular biology.
Annals of the New York Academy of Sciences 1988;548():137-45.