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David Thompson

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Chemicals & Drugs

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Sreekanth Puttachary; Alan P Robertson; David P Thompson; Sasa M Trailovic; Debra J Woods; Richard J Martin
Derquantel and abamectin: Effects and interactions on isolated tissues of Ascaris suum.
Angela Mousley; Christy L Moffett; Hanne Duve; Alan Thorpe; David W Halton; Timothy G Geary; David P Thompson; Aaron G Maule; Nikki J Marks
Expression and bioactivity of allatostatin-like neuropeptides in helminths.
Sandra S Johnson; Eileen M Coscarelli; John P Davis; R M Zaya; Jeffrey S Day; CL Barsuhn; R A Martin; Thomas J Vidmar; Byung H Lee; George A Conder; Timothy G Geary; Norman F H Ho; David P Thompson
Interrelationships among physicochemical properties, absorption and anthelmintic activities of 2-desoxoparaherquamide and selected analogs.

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All Publications

2013: Sreekanth Puttachary; Alan P Robertson; David P Thompson; Sasa M Trailovic; Debra J Woods; Richard J Martin
Derquantel and abamectin: Effects and interactions on isolated tissues of Ascaris suum.
Molecular and biochemical parasitology 2013;188(2):79-86.
2005: Angela Mousley; Christy L Moffett; Hanne Duve; Alan Thorpe; David W Halton; Timothy G Geary; David P Thompson; Aaron G Maule; Nikki J Marks
Expression and bioactivity of allatostatin-like neuropeptides in helminths.
International journal for parasitology 2005;35(14):1557-67.
2004: Sandra S Johnson; Eileen M Coscarelli; John P Davis; R M Zaya; Jeffrey S Day; CL Barsuhn; R A Martin; Thomas J Vidmar; Byung H Lee; George A Conder; Timothy G Geary; Norman F H Ho; David P Thompson
Interrelationships among physicochemical properties, absorption and anthelmintic activities of 2-desoxoparaherquamide and selected analogs.
Journal of veterinary pharmacology and therapeutics 2004;27(3):169-81.
2004: Angela Mousley; Nikki J Marks; David W Halton; Timothy G Geary; David P Thompson; Aaron G Maule
Arthropod FMRFamide-related peptides modulate muscle activity in helminths.
International journal for parasitology 2004;34(6):755-68.
2003: Christy L Moffett; A M Beckett; Angela Mousley; Timothy G Geary; Nikki J Marks; David W Halton; David P Thompson; Aaron G Maule
The ovijector of Ascaris suum: multiple response types revealed by Caenorhabditis elegans FMRFamide-related peptides.
International journal for parasitology 2003;33(8):859-76.
2003: Timothy G Geary; David P Thompson
Development of antiparasitic drugs in the 21st century.
Veterinary parasitology 2003;115(2):167-84.
2003: Kevin L Blair; Timothy G Geary; Sharon K Mensch; Thomas J Vidmar; S Kevin Li; Norman F H Ho; David P Thompson
Biophysical characterization of a large conductance anion channel in hypodermal membranes of the gastrointestinal nematode, Ascaris suum.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2003;134(4):805-18.
2003: David P Thompson; John P Davis; Martha J Larsen; Eileen M Coscarelli; Erich W Zinser; Jerry W Bowman; Susan J Alexander-Bowman; Nikki J Marks; Timothy G Geary
Effects of KHEYLRFamide and KNEFIRFamide on cyclic adenosine monophosphate levels in Ascaris suum somatic muscle.
International journal for parasitology 2003;33(2):199-208.
2002: Jerry W Bowman; Alan R Friedman; David P Thompson; Aaron G Maule; Susan J Alexander-Bowman; Timothy G Geary
Structure-activity relationships of an inhibitory nematode FMRFamide-related peptide, SDPNFLRFamide (PF1), on Ascaris suum muscle.
International journal for parasitology 2002;32(14):1765-71.
2002: Jenny Purcell; Alan P Robertson; David P Thompson; Richard J Martin
PF4, a FMRFamide-related peptide, gates low-conductance Cl(-) channels in Ascaris suum.
European journal of pharmacology 2002;456(1-3):11-7.
2002: Alan P Robertson; Cheryl L Clark; Teresa A Burns; David P Thompson; Timothy G Geary; Sasa M Trailovic; Richard J Martin
Paraherquamide and 2-deoxy-paraherquamide distinguish cholinergic receptor subtypes in Ascaris muscle.
The Journal of pharmacology and experimental therapeutics 2002;302(3):853-60.
2002: Erich W Zinser; Mark L Wolf; Susan J Alexander-Bowman; Eileen M Thomas; John P Davis; Vincent E Groppi; Byung H Lee; David P Thompson; Timothy G Geary
Anthelmintic paraherquamides are cholinergic antagonists in gastrointestinal nematodes and mammals.
Journal of veterinary pharmacology and therapeutics 2002;25(4):241-50.
2002: Byung H Lee; Michael F Clothier; Fred E Dutton; Stephen J Nelson; Sandra S Johnson; David P Thompson; Timothy G Geary; Howard D Whaley; Christopher L Haber; Vincent P Marshall; Gabe I Kornis; Patty L McNally; Joyce I Ciadella; David G Martin; Jerry W Bowman; Carol A Baker; Eileen M Coscarelli; Susan J Alexander-Bowman; John P Davis; Erich W Zinser; Veronica Wiley; Michael F Lipton; Michael A Mauragis
Marcfortine and paraherquamide class of anthelmintics: discovery of PNU-141962.
Current topics in medicinal chemistry 2002;2(7):779-93.
2002: Aaron G Maule; Angela Mousley; Nikki J Marks; Tim A Day; David P Thompson; Timothy G Geary; David W Halton
Neuropeptide signaling systems - potential drug targets for parasite and pest control.
Current topics in medicinal chemistry 2002;2(7):733-58.
2002: J Purcell; Alan P Robertson; David P Thompson; Richard J Martin
The time-course of the response to the FMRFamide-related peptide PF4 in Ascaris suum muscle cells indicates direct gating of a chloride ion-channel.
Parasitology 2002;124(Pt 6):649-56.
2002: Byung H Lee; Fred E Dutton; David P Thompson; Eileen M Thomas
Generation of a small library of cyclodepsipeptide PF1022A analogues using a cyclization-cleavage method with oxime resin.
Bioorganic & medicinal chemistry letters 2002;12(3):353-6.
2001: Timothy G Geary; David P Thompson
Caenorhabditis elegans: how good a model for veterinary parasites?
Veterinary parasitology 2001;101(3-4):371-86.
2001: Nikki J Marks; C Shaw; David W Halton; David P Thompson; Timothy G Geary; Christine Li; Aaron G Maule
Isolation and preliminary biological assessment of AADGAPLIRFamide and SVPGVLRFamide from Caenorhabditis elegans.
Biochemical and biophysical research communications 2001;286(5):1170-6.
2000: RA Fellowes; Aaron G Maule; R J Martin; Timothy G Geary; David P Thompson; Michael J Kimber; Nikki J Marks; David W Halton
Classical neurotransmitters in the ovijector of Ascaris suum: localization and modulation of muscle activity.
Parasitology 2000;121 ( Pt 3)():325-36.
2000: B A Sheehy; Norman F H Ho; Philip S Burton; Jeffrey S Day; Timothy G Geary; David P Thompson
Transport of model peptides across Ascaris suum cuticle.
Molecular and biochemical parasitology 2000;105(1):39-49.
2000: RA Fellowes; Aaron G Maule; Nikki J Marks; Timothy G Geary; David P Thompson; David W Halton
Nematode neuropeptide modulation of the vagina vera of Ascaris suum: in vitro effects of PF1, PF2, PF4, AF3 and AF4.
Parasitology 2000;120 ( Pt 1)():79-89.
1999: Timothy G Geary; Nicholas C Sangster; David P Thompson
Frontiers in anthelmintic pharmacology.
Veterinary parasitology 1999;84(3-4):275-95.
1999: Byung H Lee; Fred E Dutton; Michael F Clothier; Jerry W Bowman; John P Davis; Sandra S Johnson; Eileen M Thomas; Marjorie R Zantello; Erich W Zinser; J C McGuire; David P Thompson; Timothy G Geary
Synthesis and biological activity of anthelmintic thiadiazoles using an AF-2 receptor binding assay.
Bioorganic & medicinal chemistry letters 1999;9(12):1727-32.
1999: Nikki J Marks; Nicholas C Sangster; Aaron G Maule; David W Halton; David P Thompson; Timothy G Geary; C Shaw
Structural characterisation and pharmacology of KHEYLRFamide (AF2) and KSAYMRFamide (PF3/AF8) from Haemonchus contortus.
Molecular and biochemical parasitology 1999;100(2):185-94.
1999: Nikki J Marks; Aaron G Maule; Christine Li; L S Nelson; David P Thompson; Susan J Alexander-Bowman; Timothy G Geary; David W Halton; P Verhaert; Collin Shaw
Isolation, pharmacology and gene organization of KPSFVRFamide: a neuropeptide from Caenorhabditis elegans.
Biochemical and biophysical research communications 1999;254(1):222-30.
1999: Timothy G Geary; Nikki J Marks; Aaron G Maule; Jerry W Bowman; Susan J Alexander-Bowman; Tim A Day; Martha J Larsen; Teresa M Kubiak; John P Davis; David P Thompson
Pharmacology of FMRFamide-related peptides in helminths.
Annals of the New York Academy of Sciences 1999;897():212-27.
1999: Timothy G Geary; David P Thompson; RD Klein
Mechanism-based screening: discovery of the next generation of anthelmintics depends upon more basic research.
International journal for parasitology 1999;29(1):105-12; discussion 113-4.
1998: Nikki J Marks; Aaron G Maule; Timothy G Geary; David P Thompson; Christine Li; David W Halton; Collin Shaw
KSAYMRFamide (PF3/AF8) is present in the free-living nematode, Caenorhabditis elegans.
Biochemical and biophysical research communications 1998;248(2):422-5.
1998: J A Bacon; Roger G Ulrich; John P Davis; Eileen M Thomas; Sandra S Johnson; George A Conder; Nicholas C Sangster; J T Rothwell; R O McCracken; Byung H Lee; Michael F Clothier; Timothy G Geary; David P Thompson
Comparative in vitro effects of closantel and selected beta-ketoamide anthelmintics on a gastrointestinal nematode and vertebrate liver cells.
Journal of veterinary pharmacology and therapeutics 1998;21(3):190-8.
1998: K L Blair; CL Barsuhn; Jeffrey S Day; Norman F H Ho; Timothy G Geary; David P Thompson
Biophysical model for organic acid excretion in Ascaris suum.
Molecular and biochemical parasitology 1998;93(2):179-90.
1998: RA Fellowes; Aaron G Maule; Nikki J Marks; Timothy G Geary; David P Thompson; Collin Shaw; David W Halton
Modulation of the motility of the vagina vera of Ascaris suum in vitro by FMRF amide-related peptides.
Parasitology 1998;116 ( Pt 3)():277-87.
1997: Nikki J Marks; Aaron G Maule; David W Halton; Timothy G Geary; C Shaw; David P Thompson
Pharmacological effects of nematode FMRFamide-related peptides (FaRPs) on muscle contractility of the trematode, Fasciola hepatica.
Parasitology 1997;114 ( Pt 6)():531-9.
1997: Nikki J Marks; Aaron G Maule; Timothy G Geary; David P Thompson; J P Davis; David W Halton; P Verhaert; Collin Shaw
APEASPFIRFamide, a novel FMRFamide-related decapeptide from Caenorhabditis elegans: structure and myoactivity.
Biochemical and biophysical research communications 1997;231(3):591-5.
1996: Aaron G Maule; Timothy G Geary; Jerry W Bowman; Collin Shaw; D W Falton; David P Thompson
The Pharmacology of Nematode FMRFamide-related Peptides.
Parasitology today (Personal ed.) 1996;12(9):351-7.
1996: Aaron G Maule; Timothy G Geary; Nikki J Marks; Jerry W Bowman; A R Friedman; David P Thompson
Nematode FMRFamide-related peptide (FaRP)-systems: occurrence, distribution and physiology.
International journal for parasitology 1996;26(8-9):927-36.
1996: S M Sims; Norman F H Ho; Timothy G Geary; Eileen M Thomas; J S Day; CL Barsuhn; David P Thompson
Influence of organic acid excretion on cuticle pH and drug absorption by Haemonchus contortus.
International journal for parasitology 1996;26(1):25-35.
1996: Aaron G Maule; Jerry W Bowman; David P Thompson; Nikki J Marks; A R Friedman; Timothy G Geary
FMRFamide-related peptides (FaRPs) in nematodes: occurrence and neuromuscular physiology.
Parasitology 1996;113 Suppl():S119-35.
1996: Jerry W Bowman; A R Friedman; David P Thompson; A K Ichhpurani; M F Kellman; N Marks; Aaron G Maule; Timothy G Geary
Structure-activity relationships of KNEFIRFamide (AF1), a nematode FMRFamide-related peptide, on Ascaris suum muscle.
Peptides 1996;17(3):381-7.
1995: Nikki J Marks; Collin Shaw; Aaron G Maule; J P Davis; David W Halton; Peter Verhaert; Timothy G Geary; David P Thompson
Isolation of AF2 (KHEYLRFamide) from Caenorhabditis elegans: evidence for the presence of more than one FMRFamide-related peptide-encoding gene.
Biochemical and biophysical research communications 1995;217(3):845-51.
1995: Aaron G Maule; Timothy G Geary; Jerry W Bowman; Nikki J Marks; K L Blair; David W Halton; Collin Shaw; David P Thompson
Inhibitory effects of nematode FMRFamide-related peptides (FaRPs) on muscle strips from Ascaris suum.
Invertebrate neuroscience : IN 1995;1(3):255-65.
1995: Timothy G Geary; Jerry W Bowman; A R Friedman; Aaron G Maule; John P Davis; CA Winterrowd; RD Klein; David P Thompson
The pharmacology of FMRFamide-related neuropeptides in nematodes: new opportunities for rational anthelmintic discovery?
International journal for parasitology 1995;25(11):1273-80.
1995: Jerry W Bowman; CA Winterrowd; A R Friedman; David P Thompson; RD Klein; John P Davis; Aaron G Maule; K L Blair; Timothy G Geary
Nitric oxide mediates the inhibitory effects of SDPNFLRFamide, a nematode FMRFamide-related neuropeptide, in Ascaris suum.
Journal of neurophysiology 1995;74(5):1880-8.
1995: George A Conder; Sandra S Johnson; D S Nowakowski; T E Blake; Fred E Dutton; S J Nelson; Eileen M Thomas; John P Davis; David P Thompson
Anthelmintic profile of the cyclodepsipeptide PF1022A in in vitro and in vivo models.
The Journal of antibiotics 1995;48(8):820-3.
1995: T D Tsai; ME Shuck; David P Thompson; Michael J Bienkowski; K S Lee
Intracellular H+ inhibits a cloned rat kidney outer medulla K+ channel expressed in Xenopus oocytes.
The American journal of physiology 1995;268(5 Pt 1):C1173-8.
1995: R A Pax; T G Geary; J L Bennett; David P Thompson
Ascaris suum: characterization of transmural and hypodermal potentials.
Experimental parasitology 1995;80(1):85-97.
1995: Aaron G Maule; Collin Shaw; Jerry W Bowman; David W Halton; David P Thompson; L Thim; T M Kubiak; R A Martin; Timothy G Geary
Isolation and preliminary biological characterization of KPNFIRFamide, a novel FMRFamide-related peptide from the free-living nematode, Panagrellus redivivus.
Peptides 1995;16(1):87-93.
1994: Aaron G Maule; Collin Shaw; Jerry W Bowman; David W Halton; David P Thompson; Timothy G Geary; L Thim
The FMRFamide-like neuropeptide AF2 (Ascaris suum) is present in the free-living nematode, Panagrellus redivivus (Nematoda, Rhabditida).
Parasitology 1994;109 ( Pt 3)():351-6.
1994: Norman F H Ho; S M Sims; Thomas J Vidmar; J S Day; CL Barsuhn; Eileen M Thomas; Timothy G Geary; David P Thompson
Theoretical perspectives on anthelmintic drug discovery: interplay of transport kinetics, physicochemical properties, and in vitro activity of anthelmintic drugs.
Journal of pharmaceutical sciences 1994;83(7):1052-9.
1994: Aaron G Maule; Collin Shaw; Jerry W Bowman; David W Halton; David P Thompson; Timothy G Geary; L Thim
KSAYMRFamide: a novel FMRFamide-related heptapeptide from the free-living nematode, Panagrellus redivivus, which is myoactive in the parasitic nematode, Ascaris suum.
Biochemical and biophysical research communications 1994;200(2):973-80.
1994: S M Sims; Norman F H Ho; L T Magas; Timothy G Geary; CL Barsuhn; David P Thompson
Biophysical model of the transcuticular excretion of organic acids, cuticle pH and buffer capacity in gastrointestinal nematodes.
Journal of drug targeting 1994;2(1):1-8.
1993: Timothy G Geary; S M Sims; Eileen M Thomas; L Vanover; John P Davis; CA Winterrowd; RD Klein; Norman F H Ho; David P Thompson
Haemonchus contortus: ivermectin-induced paralysis of the pharynx.
Experimental parasitology 1993;77(1):88-96.
1993: George A Conder; David P Thompson; Sandra S Johnson
Demonstration of co-resistance of Haemonchus contortus to ivermectin and moxidectin.
The Veterinary record 1993;132(26):651-2.
1993: David P Thompson; Norman F H Ho; S M Sims; Timothy G Geary
Mechanistic approaches to quantitate anthelmintic absorption by gastrointestinal nematodes.
Parasitology today (Personal ed.) 1993;9(1):31-5.
1992: S M Sims; L T Magas; CL Barsuhn; Norman F H Ho; Timothy G Geary; David P Thompson
Mechanisms of microenvironmental pH regulation in the cuticle of Ascaris suum.
Molecular and biochemical parasitology 1992;53(1-2):135-48.
1992: Norman F H Ho; Timothy G Geary; CL Barsuhn; S M Sims; David P Thompson
Mechanistic studies in the transcuticular delivery of antiparasitic drugs. II: Ex vivo/in vitro correlation of solute transport by Ascaris suum.
Molecular and biochemical parasitology 1992;52(1):1-13.
1992: Timothy G Geary; RD Klein; L Vanover; Jerry W Bowman; David P Thompson
The nervous systems of helminths as targets for drugs.
The Journal of parasitology 1992;78(2):215-30.
1991: C L Haber; C L Heckaman; G P Li; David P Thompson; H A Whaley; V H Wiley
Development of a mechanism of action-based screen for anthelmintic microbial metabolites with avermectinlike activity and isolation of milbemycin-producing Streptomyces strains.
Antimicrobial agents and chemotherapy 1991;35(9):1811-7.
1991: Jerry W Bowman; B L Lee; H A Whaley; David P Thompson
Effects of dihydroavermectin B1a and analogs on stretcher muscle of the lined shore crab, Pachygrapsus crassipes.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1991;99(3):333-40.
1990: Norman F H Ho; Timothy G Geary; TJ Raub; CL Barsuhn; David P Thompson
Biophysical transport properties of the cuticle of Ascaris suum.
Molecular and biochemical parasitology 1990;41(2):153-65.
1989: Moo Je Cho; J F Scieszka; C T Cramer; David P Thompson; Thomas J Vidmar
Neutrophil-mediated transport of liposomes across the Madin Darby canine kidney epithelial cell monolayer.
Pharmaceutical research 1989;6(1):78-84.
1989: Moo Je Cho; David P Thompson; C T Cramer; Thomas J Vidmar; J F Scieszka
The Madin Darby canine kidney (MDCK) epithelial cell monolayer as a model cellular transport barrier.
Pharmaceutical research 1989;6(1):71-7.
1987: D D Morrison; David P Thompson; D R Semeyn; J L Bennett
Acute effects of oltipraz on adult Schistosoma mansoni and its antagonism in vitro.
Biochemical pharmacology 1987;36(7):1169-71.
1986: David P Thompson; G Z Chen; A K Sample; D R Semeyn; J L Bennett
Calmodulin: biochemical, physiological, and morphological effects on Schistosoma mansoni.
The American journal of physiology 1986;251(6 Pt 2):R1051-8.
1984: David P Thompson; D D Morrison; R A Pax; J L Bennett
Changes in glucose metabolism and cyanide sensitivity in Schistosoma mansoni during development.
Molecular and biochemical parasitology 1984;13(1):39-51.
1984: David P Thompson; R A Pax; J L Bennett
Schistosoma mansoni: a comparative study of schistosomula transformed mechanically and by skin penetration. Electrophysiological responses to a wide range of substances.
Parasitology 1984;88 ( Pt 3)():477-89.
1983: J W Depenbusch; David P Thompson; R A Pax; J L Bennett
Tegumental disruption with Triton X-100 and its effects on longitudinal muscle function in male Schistosoma mansoni.
Parasitology 1983;87 (Pt 1)():61-73.
1983: C S Bricker; J W Depenbusch; J L Bennett; David P Thompson
The relationship between tegumental disruption and muscle contraction in Schistosoma mansoni exposed to various compounds.
Zeitschrift für Parasitenkunde (Berlin, Germany) 1983;69(1):61-71.
1983: R A Pax; C S Bricker; David P Thompson; D R Semeyn; J L Bennett
Neurophysiology of adult male Schistosoma mansoni.
Pharmacology & therapeutics 1983;22(1):117-25.
1982: David P Thompson; R A Pax; J L Bennett
Microelectrode studies of the tegument and sub-tegumental compartments of male Schistosoma mansoni: an analysis of electrophysiological properties.
Parasitology 1982;85 (Pt 1)():163-78.