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Brad Thompson
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Chemicals & Drugs
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27
Johnson, Betty
13
Miller, Aaron
9
Webb, Scott
9
Kumar, Raj
9
Medh, Rheem
7
Ayala-Torres, S
5
Harmon, Jeffrey
5
Zhou, F
5
Srinivasan, G
4
Kumar, Rajiv
3
Ilies, Monica
3
Fofanov, Yuriy
3
Balaban, Alexandru
3
El-Naghy, M
3
Seitz, William
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All Publications
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2009: Garza Anna S; Miller Aaron L; Johnson Betty H; Thompson E Brad
Converting cell lines representing hematological malignancies from glucocorticoid-resistant to glucocorticoid-sensitive: signaling pathway interactions.
Leukemia research 2009;33(5):717-27.
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2008: Ji Zhenyu; Mei Fang C; Miller Aaron L; Thompson E Brad; Cheng Xiaodong
Protein kinase A (PKA) isoform RIIbeta mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells.
The Journal of biological chemistry 2008;283(32):21920-5.
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2008: Thompson E Brad
Stepping stones in the path of glucocorticoid-driven apoptosis of lymphoid cells.
Acta biochimica et biophysica Sinica 2008;40(7):595-600.
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2007: Ji Zhenyu; Mei Fang C; Johnson Betty H; Thompson E Brad; Cheng Xiaodong
Protein kinase A, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells.
The Journal of biological chemistry 2007;282(52):37370-7.
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2007: Webb M S; Miller A L; Thompson E Brad
In CEM cells the autosomal deafness gene dfna5 is regulated by glucocorticoids and forskolin.
The Journal of steroid biochemistry and molecular biology 2007;107(1-2):15-21.
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2007: Kumar R; Serrette J M; Khan S H; Miller A L; Thompson E B
Effects of different osmolytes on the induced folding of the N-terminal activation domain (AF1) of the glucocorticoid receptor.
Archives of biochemistry and biophysics 2007;465(2):452-60.
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2007: Miller Aaron L; Webb M Scott; Thompson E Brad
Comparison of two structurally diverse glucocorticoid receptor agonists: cortivazol selectively regulates a distinct set of genes separate from dexamethasone in CEM cells.
Steroids 2007;72(9-10):673-81.
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2007: Hilser Vincent J; Thompson E Brad
Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(20):8311-5.
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2007: Miller Aaron L; Komak Spogmai; Webb M Scott; Leiter Edward H; Thompson E Brad
Gene expression profiling of leukemic cells and primary thymocytes predicts a signature for apoptotic sensitivity to glucocorticoids.
Cancer cell international 2007;7():18.
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2007: Miller Aaron L; Garza Anna S; Johnson Betty H; Thompson E Brad
Pathway interactions between MAPKs, mTOR, PKA, and the glucocorticoid receptor in lymphoid cells.
Cancer cell international 2007;7():3.
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2006: Ilies Marc Antoniu; Seitz William A; Johnson Betty H; Ezell Edward L; Miller Aaron L; Thompson E Brad; Balaban Alexandru T
Lipophilic pyrylium salts in the synthesis of efficient pyridinium-based cationic lipids, gemini surfactants, and lipophilic oligomers for gene delivery.
Journal of medicinal chemistry 2006;49(13):3872-87.
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2006: Copik Alicja J; Webb M Scott; Miller Aaron L; Wang Yongxin; Kumar Raj; Thompson E Brad
Activation function 1 of glucocorticoid receptor binds TATA-binding protein in vitro and in vivo.
Molecular endocrinology (Baltimore, Md.) 2006;20(6):1218-30.
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2005: Miller Aaron L; Webb M Scott; Copik Alicja J; Wang Yongxin; Johnson Betty H; Kumar Raj; Thompson E Brad
p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211.
Molecular endocrinology (Baltimore, Md.) 2005;19(6):1569-83.
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2005: Kumar Raj; Thompson E Brad
Gene regulation by the glucocorticoid receptor: structure:function relationship.
The Journal of steroid biochemistry and molecular biology 2005;94(5):383-94.
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2005: Kumar Raj; Serrette Justin M; Thompson E Brad
Osmolyte-induced folding enhances tryptic enzyme activity.
Archives of biochemistry and biophysics 2005;436(1):78-82.
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2005: Ilies Marc A; Johnson Betty H; Makori Fred; Miller Aaron; Seitz William A; Thompson E Brad; Balaban Alexandru T
Pyridinium cationic lipids in gene delivery: an in vitro and in vivo comparison of transfection efficiency versus a tetraalkylammonium congener.
Archives of biochemistry and biophysics 2005;435(1):217-26.
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2004: Kumar Raj; Volk David E; Li Jianquan; Lee James C; Gorenstein David G; Thompson E Brad
TATA box binding protein induces structure in the recombinant glucocorticoid receptor AF1 domain.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16425-30.
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2004: Thompson E B; Webb M S; Miller A L; Fofanov Y; Johnson B H
Identification of genes leading to glucocorticoid-induced leukemic cell death.
Lipids 2004;39(8):821-5.
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2004: Ilies Marc Antoniu; Seitz William A; Ghiviriga Ion; Johnson Betty H; Miller Aaron; Thompson E Brad; Balaban Alexandru T
Pyridinium cationic lipids in gene delivery: a structure-activity correlation study.
Journal of medicinal chemistry 2004;47(15):3744-54.
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2004: Kumar Raj; Betney Russell; Li Jianquan; Thompson E Brad; McEwan Iain J
Induced alpha-helix structure in AF1 of the androgen receptor upon binding transcription factor TFIIF.
Biochemistry 2004;43(11):3008-13.
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2004: Kumar Raj; Johnson Betty H; Thompson E Brad
Overview of the structural basis for transcription regulation by nuclear hormone receptors.
Essays in biochemistry 2004;40():27-39.
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2003: Webb M Scott; Miller Aaron L; Johnson Betty H; Fofanov Yuriy; Li Tongbin; Wood Thomas G; Thompson E Brad
Gene networks in glucocorticoid-evoked apoptosis of leukemic cells.
The Journal of steroid biochemistry and molecular biology 2003;85(2-5):183-93.
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2003: Thompson E Brad; Kumar Raj
DNA binding of nuclear hormone receptors influences their structure and function.
Biochemical and biophysical research communications 2003;306(1):1-4.
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2003: Medh Rheem D; Webb M Scott; Miller Aaron L; Johnson Betty H; Fofanov Yuriy; Li Tongbin; Wood Thomas G; Luxon Bruce A; Thompson E Brad
Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis.
Genomics 2003;81(6):543-55.
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2003: Kumar Raj; Thompson E Brad
Transactivation functions of the N-terminal domains of nuclear hormone receptors: protein folding and coactivator interactions.
Molecular endocrinology (Baltimore, Md.) 2003;17(1):1-10.
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2003: Thompson E Brad; Johnson Betty H
Regulation of a distinctive set of genes in glucocorticoid-evoked apoptosis in CEM human lymphoid cells.
Recent progress in hormone research 2003;58():175-97.
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2002: Ji Yan-shan; Johnson Betty H; Webb M Scott; Thompson E Brad
Mutational analysis of DBD*--a unique antileukemic gene sequence.
Neoplasia (New York, N.Y.) 2002;4(5):417-23.
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2002: Thompson E Brad
The impact of genomics and proteomics on endocrinology.
Endocrine reviews 2002;23(3):366-8.
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2002: Choudhary S; Zhang W; Zhou F; Campbell G A; Chan L L; Thompson E B; Ansari N H
Cellular lipid peroxidation end-products induce apoptosis in human lens epithelial cells.
Free radical biology & medicine 2002;32(4):360-9.
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2002: Miller Aaron L; Johnson Betty H; Medh Rheem D; Townsend Courtney M; Thompson E Brad
Glucocorticoids and polyamine inhibitors synergize to kill human leukemic CEM cells.
Neoplasia (New York, N.Y.) 2002;4(1):68-81.
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2001: El-Naghy M; Johnson B H; Chen H; Ansari N H; Zhang W; Moller P; Ji Ys; Thompson E B
The pathway of leukemic cell death caused by glucocorticoid receptor fragment 465*.
Experimental cell research 2001;270(2):166-75.
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2001: Medh R D; Wang A; Zhou F; Thompson E B
Constitutive expression of ectopic c-Myc delays glucocorticoid-evoked apoptosis of human leukemic CEM-C7 cells.
Oncogene 2001;20(34):4629-39.
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2001: Kumar R; Lee J C; Bolen D W; Thompson E B
The conformation of the glucocorticoid receptor af1/tau1 domain induced by osmolyte binds co-regulatory proteins.
The Journal of biological chemistry 2001;276(21):18146-52.
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2001: Zhang W; He Q; Chan L L; Zhou F; El Naghy M; Thompson E B; Ansari N H
Involvement of caspases in 4-hydroxy-alkenal-induced apoptosis in human leukemic cells.
Free radical biology & medicine 2001;30(6):699-706.
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2000: Zhou F; Medh R D; Zhang W; Ansari N H; Thompson E B
The delayed induction of c-jun in apoptotic human leukemic lymphoblasts is primarily transcriptional.
The Journal of steroid biochemistry and molecular biology 2000;75(2-3):91-9.
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2000: Zhou F; Medh R D; Thompson E B
Glucocorticoid mediated transcriptional repression of c-myc in apoptotic human leukemic CEM cells.
The Journal of steroid biochemistry and molecular biology 2000;73(5):195-202.
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2000: Medh R D; Thompson E B
Hormonal regulation of physiological cell turnover and apoptosis.
Cell and tissue research 2000;301(1):101-24.
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2000: Johnson B H; Russell M J; Krylov A S; Medh R D; Ayala-Torres S; Regner J L; Thompson E B
Structure-apoptotic potency evaluations of novel sterols using human leukemic cells.
Lipids 2000;35(3):305-15.
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1999: Kumar R; Baskakov I V; Srinivasan G; Bolen D W; Lee J C; Thompson E B
Interdomain signaling in a two-domain fragment of the human glucocorticoid receptor.
The Journal of biological chemistry 1999;274(35):24737-41.
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1999: Kumar R; Thompson E B
The structure of the nuclear hormone receptors.
Steroids 1999;64(5):310-9.
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1999: Thompson E B; Medh R D; Zhou F; Ayala-Torres S; Ansari N; Zhang W; Johnson B H
Glucocorticoids, oxysterols, and cAMP with glucocorticoids each cause apoptosis of CEM cells and suppress c-myc.
The Journal of steroid biochemistry and molecular biology 1999;69(1-6):453-61.
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1999: Baskakov I V; Kumar R; Srinivasan G; Ji Y S; Bolen D W; Thompson E B
Trimethylamine N-oxide-induced cooperative folding of an intrinsically unfolded transcription-activating fragment of human glucocorticoid receptor.
The Journal of biological chemistry 1999;274(16):10693-6.
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1999: Biswas T; Ramana C V; Srinivasan G; Boldogh I; Hazra T K; Chen Z; Tano K; Thompson E B; Mitra S
Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone.
Oncogene 1999;18(2):525-32.
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1999: Ayala-Torres S; Zhou F; Thompson E B
Apoptosis induced by oxysterol in CEM cells is associated with negative regulation of c-myc.
Experimental cell research 1999;246(1):193-202.
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1999: Thompson E B; Ayala-Torres S
Oxysterols and apoptosis: evidence for gene regulation outside the cholesterol pathway.
Critical reviews in biochemistry and molecular biology 1999;34(1):25-32.
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1998: Medh R D; Saeed M F; Johnson B H; Thompson E B
Resistance of human leukemic CEM-C1 cells is overcome by synergism between glucocorticoid and protein kinase A pathways: correlation with c-Myc suppression.
Cancer research 1998;58(16):3684-93.
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1998: Thompson E B
Steroids, gene expression, and apoptosis: recollections of contributions and controversies.
Steroids 1998;63(7-8):368-74.
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1998: Thompson E B
The many roles of c-Myc in apoptosis.
Annual review of physiology 1998;60():575-600.
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1997: Chen H; Srinivasan G; Thompson E B
Protein-protein interactions are implied in glucocorticoid receptor mutant 465*-mediated cell death.
The Journal of biological chemistry 1997;272(41):25873-80.
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1997: Ayala-Torres S; Moller P C; Johnson B H; Thompson E B
Characteristics of 25-hydroxycholesterol-induced apoptosis in the human leukemic cell line CEM.
Experimental cell research 1997;235(1):35-47.
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1997: Johnson B H; Ayala-Torres S; Chan L N; El-Naghy M; Thompson E B
Glucocorticoid/oxysterol-induced DNA lysis in human leukemic cells.
The Journal of steroid biochemistry and molecular biology 1997;61(1-2):35-45.
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1997: Srinivasan G; Post J F; Thompson E B
Optimal ligand binding by the recombinant human glucocorticoid receptor and assembly of the receptor complex with heat shock protein 90 correlate with high intracellular ATP levels in Spodoptera frugiperda cells.
The Journal of steroid biochemistry and molecular biology 1997;60(1-2):1-9.
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1996: Nazareth L V; Johnson B H; Chen H; Thompson E B
Transfected glucocorticoid receptor and certain GR fragments evoke cell death in malignant lymphoid, not myeloid cell lines.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1996;10(11):1789-95.
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1996: Zhou F; Thompson E B
Role of c-jun induction in the glucocorticoid-evoked apoptotic pathway in human leukemic lymphoblasts.
Molecular endocrinology (Baltimore, Md.) 1996;10(3):306-16.
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1996: Kawa S K; Thompson E B
Lymphoid cell resistance to glucocorticoids in HIV infection.
The Journal of steroid biochemistry and molecular biology 1996;57(5-6):259-63.
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1995: Juneja H S; Harvey W H; Brasher W K; Thompson E B
Successful in vitro purging of leukemic blasts from marrow by cortivazol, a pyrazolosteroid: a preclinical study for autologous transplantation in acute lymphoblastic leukemia and non-Hodgkin's lymphoma.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(10):1771-8.
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1995: Ducouret B; Tujague M; Ashraf J; Mouchel N; Servel N; Valotaire Y; Thompson E B
Cloning of a teleost fish glucocorticoid receptor shows that it contains a deoxyribonucleic acid-binding domain different from that of mammals.
Endocrinology 1995;136(9):3774-83.
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1995: Thompson E B
Steroid hormones. Membrane transporters of steroid hormones.
Current biology : CB 1995;5(7):730-2.
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1995: Thompson E B; Thulasi R; Saeed M F; Johnson B H
Glucocorticoid antagonist RU 486 reverses agonist-induced apoptosis and c-myc repression in human leukemic CEM-C7 cells.
Annals of the New York Academy of Sciences 1995;761():261-75.
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1995: Nazareth L V; Thompson E B
Leukemic cell apoptosis caused by constitutively active mutant glucocorticoid receptor fragments.
Recent progress in hormone research 1995;50():417-21.
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1994: Thompson E B
Apoptosis and steroid hormones.
Molecular endocrinology (Baltimore, Md.) 1994;8(6):665-73.
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1994: Ayala-Torres S; Johnson B H; Thompson E B
Oxysterol sensitive and resistant lymphoid cells: correlation with regulation of cellular nucleic acid binding protein mRNA.
The Journal of steroid biochemistry and molecular biology 1994;48(4):307-15.
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1994: Srinivasan G; Patel N T; Thompson E B
Heat shock protein is tightly associated with the recombinant human glucocorticoid receptor:glucocorticoid response element complex.
Molecular endocrinology (Baltimore, Md.) 1994;8(2):189-96.
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1994: Gupta V; Thompson E B; Stock-Novack D; Salmon S E; Pierce H I; Bonnet J D; Chilton D; Beckford J
Efficacy of prednisone in refractory multiple myeloma and measurement of glucocorticoid receptors. A Southwest Oncology Group study.
Investigational new drugs 1994;12(2):121-8.
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1993: Bakos J T; Johnson B H; Thompson E B
Oxysterol-induced cell death in human leukemic T-cells correlates with oxysterol binding protein occupancy and is independent of glucocorticoid-induced apoptosis.
The Journal of steroid biochemistry and molecular biology 1993;46(4):415-26.
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1993: Smith J S; Kawa S; Cloyd M W; Thompson E B
Interactions between human immunodeficiency virus infection and hormonal pathways: enhancement of calcium-induced but reduction of glucocorticoid-induced cell death.
Endocrinology 1993;133(3):1085-91.
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1993: Thulasi R; Harbour D V; Thompson E B
Suppression of c-myc is a critical step in glucocorticoid-induced human leukemic cell lysis.
The Journal of biological chemistry 1993;268(24):18306-12.
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1993: Kawa S; Kumar A; Smith J S; Becerra S P; Beard W A; Wilson S H; Thompson E B
Expression and purification of the HIV-1 reverse transcriptase using the baculovirus expression vector system.
Protein expression and purification 1993;4(4):298-303.
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1993: Danel-Moore L; Kawa S; Kalmaz G D; Bessman D; Thompson E B
Induction of CD8 antigen and suppressor activity by glucocorticoids in a CEM human leukemic cell clone.
Leukemia research 1993;17(6):501-6.
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1993: Ashraf J; Thompson E B
Identification of the activation-labile gene: a single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes.
Molecular endocrinology (Baltimore, Md.) 1993;7(5):631-42.
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1993: Evers B M; Thompson E B; Townsend C M; Lawrence J L; Johnson B; Srinivasan G; Thompson J C
Cortivazol increases glucocorticoid receptor expression and inhibits growth of hamster pancreatic cancer (H2T) in vivo.
Pancreas 1993;8(1):7-14.
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1993: Ashraf J; Thompson E B
Glucocorticoid receptors in leukemias, lymphomas and myelomas of young and old.
Advances in experimental medicine and biology 1993;330():241-69.
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1993: Srinivasan G; Patel N T; Thompson E B
Characterization of the human oxysterol receptor overexpressed in the baculovirus system.
Receptor 1993;3(2):99-111.
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1992: Supowit S C; Ramsey T; Thompson E B
Extinction of prolactin gene expression in somatic cell hybrids is correlated with the repression of the pituitary-specific trans-activator GHF-1/Pit-1.
Molecular endocrinology (Baltimore, Md.) 1992;6(5):786-92.
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1992: Thompson E B
Comment: single receptors, dual second messengers.
Molecular endocrinology (Baltimore, Md.) 1992;6(4):501.
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1992: Johnson B H; Dean R R; Moran S M; Thompson E B
Glucocorticoid, interleukin-2, and prostaglandin interactions in a clonal human leukemic T-cell line.
The Journal of steroid biochemistry and molecular biology 1992;42(1):1-9.
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1992: Thompson E B; Nazareth L V; Thulasi R; Ashraf J; Harbour D; Johnson B H
Glucocorticoids in malignant lymphoid cells: gene regulation and the minimum receptor fragment for lysis.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):273-82.
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1991: Nazareth L V; Harbour D V; Thompson E B
Mapping the human glucocorticoid receptor for leukemic cell death.
The Journal of biological chemistry 1991;266(20):12976-80.
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1991: Ashraf J; Kunapuli S; Chilton D; Thompson E B
Cortivazol mediated induction of glucocorticoid receptor messenger ribonucleic acid in wild-type and dexamethasone-resistant human leukemic (CEM) cells.
The Journal of steroid biochemistry and molecular biology 1991;38(5):561-8.
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1990: Patel N T; Thompson E B
Human oxysterol-binding protein. I. Identification and characterization in liver.
The Journal of clinical endocrinology and metabolism 1990;71(6):1637-45.
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1990: Zong J; Ashraf J; Thompson E B
The promoter and first, untranslated exon of the human glucocorticoid receptor gene are GC rich but lack consensus glucocorticoid receptor element sites.
Molecular and cellular biology 1990;10(10):5580-5.
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1990: Srivastava D; Thompson E B
Two glucocorticoid binding sites on the human glucocorticoid receptor.
Endocrinology 1990;127(4):1770-8.
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1990: Chilton D G; Johnson B H; Danel-Moore L; Kawa S; Thompson E B
Increased glucocorticoid responsiveness of CD4+ T-cell clonal lines grown in serum-free media.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1990;26(6):561-70.
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1990: Gomi M; Moriwaki K; Katagiri S; Kurata Y; Thompson E B
Glucocorticoid effects on myeloma cells in culture: correlation of growth inhibition with induction of glucocorticoid receptor messenger RNA.
Cancer research 1990;50(6):1873-8.
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1990: Srinivasan G; Thompson E B
Overexpression of full-length human glucocorticoid receptor in Spodoptera frugiperda cells using the baculovirus expression vector system.
Molecular endocrinology (Baltimore, Md.) 1990;4(2):209-16.
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1990: Harbour D V; Chambon P; Thompson E B
Steroid mediated lysis of lymphoblasts requires the DNA binding region of the steroid hormone receptor.
Journal of steroid biochemistry 1990;35(1):1-9.
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1989: Yuh Y S; Thompson E B
Glucocorticoid effect on oncogene/growth gene expression in human T lymphoblastic leukemic cell line CCRF-CEM. Specific c-myc mRNA suppression by dexamethasone.
The Journal of biological chemistry 1989;264(18):10904-10.
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1989: Harmon J M; Elsasser M S; Eisen L P; Urda L A; Ashraf J; Thompson E B
Glucocorticoid receptor expression in receptorless mutants isolated from the human leukemic cell line CEM-C7.
Molecular endocrinology (Baltimore, Md.) 1989;3(4):734-43.
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1989: Thompson E B; Srivastava D; Johnson B H
Interactions of the phenylpyrazolo steroid cortivazol with glucocorticoid receptors in steroid-sensitive and -resistant human leukemic cells.
Cancer research 1989;49(8 Suppl):2253s-2258s.
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1989: Linder M J; Thompson E B
Abnormal glucocorticoid receptor gene and mRNA in primary cortisol resistance.
Journal of steroid biochemistry 1989;32(2):243-9.
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1988: Thompson E B; Yuh Y S; Ashraf J; Gametchu B; Johnson B; Harmon J M
Mechanisms of glucocorticoid function in human leukemic cells: analysis of receptor gene mutants of the activation-labile type using the covalent affinity ligand dexamethasone mesylate.
Journal of steroid biochemistry 1988;30(1-6):63-70.
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1987: Thompson E B
The structure of the human glucocorticoid receptor and its gene.
Journal of steroid biochemistry 1987;27(1-3):105-8.
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1985: Eisen L P; Reichman M E; Thompson E B; Gametchu B; Harrison R W; Eisen H J
Monoclonal antibody to the rat glucocorticoid receptor. Relationship between the immunoreactive and DNA-binding domain.
The Journal of biological chemistry 1985;260(21):11805-10.
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1985: Weinberger C; Hollenberg S M; Ong E S; Harmon J M; Brower S T; Cidlowski J; Thompson E B; Rosenfeld M G; Evans R M
Identification of human glucocorticoid receptor complementary DNA clones by epitope selection.
Science (New York, N.Y.) 1985;228(4700):740-2.
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1984: Harmon J M; Eisen H J; Brower S T; Simons S S; Langley C L; Thompson E B
Identification of human leukemic glucocorticoid receptors using affinity labeling and anti-human glucocorticoid receptor antibodies.
Cancer research 1984;44(10):4540-7.
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1981: Thompson E B; Simons S S; Harmon J M
Deacylcortivazol, a potent glucocorticoid with unusual structure and unusual anti-leukemic cell activity.
Advances in experimental medicine and biology 1981;138():315-24.
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