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Timothy Thompson

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Salahaldin A Tahir; Jianxiang Wang; Guang Yang; Wenjun Chang; Alexei Goltsov; Chengzhen Ren; Ki-Duk Song; Timothy C Thompson
Caveolin-1-LRP6 signaling module stimulates aerobic glycolysis in prostate cancer.
Salahaldin A Tahir; Ryuta Tanimoto; Alexei Goltsov; Shinji Kurosaka; Sanghee Park; Timothy C Thompson
Serum caveolin-1, a biomarker of drug response and therapeutic target in prostate cancer models.
Guang Yang; Patricia Troncoso; Jorge Blando; Francesco J DeMayo; John DiGiovanni; Kohei Edamura; Alexei Goltsov; Shinji Kurosaka; Richard Logothetis; Chengzhen Ren; Timothy C Thompson
Caveolin-1 upregulation contributes to c-Myc-induced high-grade prostatic intraepithelial neoplasia and prostate cancer.

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2013: Salahaldin A Tahir; Jianxiang Wang; Guang Yang; Wenjun Chang; Alexei Goltsov; Chengzhen Ren; Ki-Duk Song; Timothy C Thompson
Caveolin-1-LRP6 signaling module stimulates aerobic glycolysis in prostate cancer.
Cancer research 2013;73(6):1900-11.
2013: Salahaldin A Tahir; Ryuta Tanimoto; Alexei Goltsov; Shinji Kurosaka; Sanghee Park; Timothy C Thompson
Serum caveolin-1, a biomarker of drug response and therapeutic target in prostate cancer models.
Cancer biology & therapy 2013;14(2):117-26.
2012: Guang Yang; Patricia Troncoso; Jorge Blando; Francesco J DeMayo; John DiGiovanni; Kohei Edamura; Alexei Goltsov; Shinji Kurosaka; Richard Logothetis; Chengzhen Ren; Timothy C Thompson
Caveolin-1 upregulation contributes to c-Myc-induced high-grade prostatic intraepithelial neoplasia and prostate cancer.
Molecular cancer research : MCR 2012;10(2):218-29.
2011: Guru Sonpavde; Ken-Ichi Tabata; Timothy C Thompson; Thomas M Wheeler; Shinji Kurosaka; Brian J Miles; Martha P Mims; Chengzhen Ren; Gustavo E Ayala; Kohei Edamura; Adrian Gee; Alexei A Goltsov; Teresa G Hayes; Michael M Ittmann; Rajul K Jain; Dov Kadmon
GLIPR1 tumor suppressor gene expressed by adenoviral vector as neoadjuvant intraprostatic injection for localized intermediate or high-risk prostate cancer preceding radical prostatectomy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(22):7174-82.
2011: Daniel Floryk; Alexei Goltsov; Shinji Kurosaka; Sanghee Park; Ryuta Tanimoto; Guang Yang; Timothy C Thompson
Castration-induced changes in mouse epididymal white adipose tissue.
Molecular and cellular endocrinology 2011;345(1-2):58-67.
2011: Ken-Ichi Tabata; Jian Wang; Masami Watanabe; Guang Yang; E Abdelfattah; Kohei Edamura; Daniel Floryk; Alexei Goltsov; S Kurosaka; Takefumi Satoh; Timothy C Thompson
Tumor growth and metastasis suppression by Glipr1 gene-modified macrophages in a metastatic prostate cancer model.
Gene therapy 2011;18(10):969-78.
2011: Timothy C Thompson
Turning reciprocal feedback regulation into combination therapy.
Cancer cell 2011;19(6):697-9.
2011: Yuanhong Gao; Hiromichi Ishiyama; Mianen Sun; Kathryn L Brinkman; Xiaozhen Wang; Julie Zhu; Weiyuan Mai; Ying Huang; Daniel Floryk; Michael Ittmann; Timothy C Thompson; E Brian Butler; Bo Xu; Bin S Teh
The alkylphospholipid, perifosine, radiosensitizes prostate cancer cells both in vitro and in vivo.
Radiation oncology (London, England) 2011;6():39.
2010: Guang Yang; Sanghee Park; Guangwen Cao; Alexei Goltsov; Chengzhen Ren; Luan D Truong; Francesco Demayo; Timothy C Thompson
MMTV promoter-regulated caveolin-1 overexpression yields defective parenchymal epithelia in multiple exocrine organs of transgenic mice.
Experimental and molecular pathology 2010;89(1):9-19.
2010: Paul G Corn; Timothy C Thompson
Identification of a novel prostate cancer biomarker, caveolin-1: Implications and potential clinical benefit.
Cancer management and research 2010;2():111-22.
2009: Ken-Ichi Tabata; M Watanabe; Koji Naruishi; K Edamura; Takefumi Satoh; Guang Yang; E Abdel Fattah; Jian Wang; Alexei Goltsov; Daniel Floryk; S D Soni; Dov Kadmon; Timothy C Thompson
Therapeutic effects of gelatin matrix-embedded IL-12 gene-modified macrophages in a mouse model of residual prostate cancer.
Prostate cancer and prostatic diseases 2009;12(3):301-9.
2008: Daniel Floryk; Timothy C Thompson
Antiproliferative effects of AVN944, a novel inosine 5-monophosphate dehydrogenase inhibitor, in prostate cancer cells.
International journal of cancer. Journal international du cancer 2008;123(10):2294-302.
2008: Daniel Floryk; Timothy C Thompson
Perifosine induces differentiation and cell death in prostate cancer cells.
Cancer letters 2008;266(2):216-26.
2008: Guang Yang; Terry L Timme; Koji Naruishi; Tetsuo Fujita; El Moataz Abdel Fattah; Guangwen Cao; Kartik Rajagopalan; Kartik Rajocopolan; Luan D Troung; Timothy C Thompson
Mice with cav-1 gene disruption have benign stromal lesions and compromised epithelial differentiation.
Experimental and molecular pathology 2008;84(2):131-40.
2008: Salahaldin A Tahir; Guang Yang; Alexei Goltsov; Masami Watanabe; Ken-ichi Tabata; Josephine Addai; El Moataz Abdel Fattah; Dov Kadmon; Timothy C Thompson
Tumor cell-secreted caveolin-1 has proangiogenic activities in prostate cancer.
Cancer research 2008;68(3):731-9.
2008: Likun Li; ElMoataz Abdel Fattah; Guangwen Cao; Chengzhen Ren; Guang Yang; Alexei Goltsov; A Craig Chinault; Wei-Wen Cai; Terry L Timme; Timothy C Thompson
Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species-c-Jun-NH2 kinase signaling.
Cancer research 2008;68(2):434-43.
2007: Guang Yang; Josephine Addai; Thomas M Wheeler; Anna Frolov; Brian J Miles; Dov Kadmon; Timothy C Thompson
Correlative evidence that prostate cancer cell-derived caveolin-1 mediates angiogenesis.
Human pathology 2007;38(11):1688-95.
2007: H Wang; Guang Yang; Terry L Timme; T Fujita; Koji Naruishi; Anna Frolov; Malcolm K Brenner; Dov Kadmon; Timothy C Thompson
IL-12 gene-modified bone marrow cell therapy suppresses the development of experimental metastatic prostate cancer.
Cancer gene therapy 2007;14(10):819-27.
2007: Rile Li; Sibel Erdamar; Hong Dai; Thomas M Wheeler; Anna Frolov; Peter T Scardino; Timothy C Thompson; Gustavo E Ayala
Forkhead protein FKHR and its phosphorylated form p-FKHR in human prostate cancer.
Human pathology 2007;38(10):1501-7.
2007: Yasutomo Nasu; Takashi Saika; Shin Ebara; Nobuyuki Kusaka; Haruki Kaku; Fernando Abarzua; Daisuke Manabe; Timothy C Thompson; Hiromi Kumon
Suicide gene therapy with adenoviral delivery of HSV-tK gene for patients with local recurrence of prostate cancer after hormonal therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(4):834-40.
2007: Timothy C Thompson; Ronald Rodriguez
Gene therapy prolongs PSA doubling time in prostate cancer patients.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(3):442-3.
2007: H Henry Lai; Timothy B Boone; Timothy C Thompson; Christopher P Smith; George Somogyi
Using caveolin-1 knockout mouse to study impaired detrusor contractility and disrupted muscarinic activity in the aging bladder.
Urology 2007;69(2):407-11.
2007: T Fujita; Terry L Timme; Ken-Ichi Tabata; Koji Naruishi; Nobuyuki Kusaka; M Watanabe; E Abdelfattah; J X Zhu; Chengzhen Ren; C Ren; Guang Yang; Alexei Goltsov; Hongyu Wang; Maria T Vlachaki; Bin S Teh; E. Brian Butler; Timothy C Thompson
Cooperative effects of adenoviral vector-mediated interleukin 12 gene therapy with radiotherapy in a preclinical model of metastatic prostate cancer.
Gene therapy 2007;14(3):227-36.
2006: Timothy C Thompson
Exploiting the complex biology of prostate cancer.
Cancer biology & therapy 2006;5(11):1573-6.
2006: Salahaldin A Tahir; Anna Frolov; Teresa G Hayes; Martha P Mims; Brian J Miles; Seth P Lerner; Thomas M Wheeler; Gustavo Ayala; Timothy C Thompson; Dov Kadmon
Preoperative serum caveolin-1 as a prognostic marker for recurrence in a radical prostatectomy cohort.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(16):4872-5.
2006: Chengzhen Ren; Cheng-Hui Ren; Likun Li; Alexei Goltsov; Timothy C Thompson
Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster.
Genomics 2006;88(2):163-72.
2006: Koji Naruishi; Terry L Timme; Nobuyuki Kusaka; T Fujita; Guang Yang; Alexei Goltsov; Takefumi Satoh; X Ji; Weihua Tian; E Abdelfattah; Taoyan Men; M Watanabe; Ken-Ichi Tabata; Timothy C Thompson
Adenoviral vector-mediated RTVP-1 gene-modified tumor cell-based vaccine suppresses the development of experimental prostate cancer.
Cancer gene therapy 2006;13(7):658-63.
2006: Gustavo E Ayala; Hong Dai; Salahaldin A Tahir; Rile Li; Terry L Timme; Michael Ittmann; Anna Frolov; Thomas M Wheeler; David Rowley; Timothy C Thompson
Stromal antiapoptotic paracrine loop in perineural invasion of prostatic carcinoma.
Cancer research 2006;66(10):5159-64.
2006: Tetsuo Fujita; Bin S Teh; Terry L Timme; Wei-Yuan Mai; Takefumi Satoh; Nobuyuki Kusaka; Koji Naruishi; Elmoataz Abdel Fattah; Estuardo Aguilar-Cordova; E. Brian Butler; Timothy C Thompson
Sustained long-term immune responses after in situ gene therapy combined with radiotherapy and hormonal therapy in prostate cancer patients.
International journal of radiation oncology, biology, physics 2006;65(1):84-90.
2006: Gustavo Ayala; Takefumi Satoh; Rile Li; Moshe Shalev; Yehoshua Gdor; Estuardo Aguilar-Cordova; Anna Frolov; Thomas M Wheeler; Brian J Miles; Kate Rauen; Bin S Teh; E. Brian Butler; Timothy C Thompson; Dov Kadmon
Biological response determinants in HSV-tk + ganciclovir gene therapy for prostate cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(4):716-28.
2006: Gustavo E Ayala; Hong Dai; Rile Li; Michael Ittmann; Timothy C Thompson; David Rowley; Thomas M Wheeler
Bystin in perineural invasion of prostate cancer.
The Prostate 2006;66(3):266-72.
2006: Michael T Tetzlaff; Bin S Teh; Terry L Timme; Tetsuo Fujita; Takefumi Satoh; Ken-Ichi Tabata; Wei-Yuan Mai; Maria T Vlachaki; Robert J Amato; Dov Kadmon; Brian J Miles; Gustavo Ayala; Thomas M Wheeler; Estuardo Aguilar-Cordova; Timothy C Thompson; E. Brian Butler
Expanding the therapeutic index of radiation therapy by combining in situ gene therapy in the treatment of prostate cancer.
Technology in cancer research & treatment 2006;5(1):23-36.
2006: Moon S Koh; Michael Ittmann; Dov Kadmon; Timothy C Thompson; Fredrick S Leach
CDC4 gene expression as potential biomarker for targeted therapy in prostate cancer.
Cancer biology & therapy 2006;5(1):78-83.
2006: Takashi Saika; Nobuyuki Kusaka; Vladimir Mouraviev; Takefumi Satoh; Hiromi Kumon; Terry L Timme; Timothy C Thompson
Therapeutic effects of adoptive splenocyte transfer following in situ AdIL-12 gene therapy in a mouse prostate cancer model.
Cancer gene therapy 2006;13(1):91-8.
2005: Guang Yang; Terry L Timme; Anna Frolov; Thomas M Wheeler; Timothy C Thompson
Combined c-Myc and caveolin-1 expression in human prostate carcinoma predicts prostate carcinoma progression.
Cancer 2005;103(6):1186-94.
2005: L Li; M M Ittmann; Gustavo Ayala; M-J Tsai; R J Amato; T M Wheeler; Brian J Miles; Dov Kadmon; Timothy C Thompson
The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
Prostate cancer and prostatic diseases 2005;8(2):108-18.
2004: H Henry Lai; Timothy B Boone; Guang Yang; Christopher P Smith; Susanna Kiss; Timothy C Thompson; George Somogyi
Loss of caveolin-1 expression is associated with disruption of muscarinic cholinergic activities in the urinary bladder.
Neurochemistry international 2004;45(8):1185-93.
2004: Gustavo E Ayala; Hong Dai; Michael Ittmann; Rile Li; Michael Powell; Anna Frolov; Thomas M Wheeler; Timothy C Thompson; David Rowley
Growth and survival mechanisms associated with perineural invasion in prostate cancer.
Cancer research 2004;64(17):6082-90.
2004: Xiao-Mei Rao; Michael T Tseng; Xinyu Zheng; Yanbin Dong; Azemat Jamshidi-Parsian; Timothy C Thompson; Malcolm K Brenner; Kelly M McMasters; Heshan Sam Zhou
E1A-induced apoptosis does not prevent replication of adenoviruses with deletion of E1b in majority of infected cancer cells.
Cancer gene therapy 2004;11(9):585-93.
2004: Takefumi Satoh; Bin S Teh; Terry L Timme; Wei-Yuan Mai; Yehoshua Gdor; Nobuyuki Kusaka; Tetsuo Fujita; Christins K Pramudji; Maria T Vlachaki; Gustavo Ayala; Thomas Wheeler; Robert J Amato; Brian J Miles; Dov Kadmon; E. Brian Butler; Timothy C Thompson
Enhanced systemic T-cell activation after in situ gene therapy with radiotherapy in prostate cancer patients.
International journal of radiation oncology, biology, physics 2004;59(2):562-71.
2004: Takashi Saika; Takefumi Satoh; Nobuyuki Kusaka; Shin Ebara; Vladimir Mouraviev; Terry L Timme; Timothy C Thompson
Route of administration influences the antitumor effects of bone marrow-derived dendritic cells engineered to produce interleukin-12 in a metastatic mouse prostate cancer model.
Cancer gene therapy 2004;11(5):317-24.
2004: Guang Yang; Josephine Addai; Wei-hua Tian; Anna Frolov; Thomas M Wheeler; Timothy C Thompson
Reduced infiltration of class A scavenger receptor positive antigen-presenting cells is associated with prostate cancer progression.
Cancer research 2004;64(6):2076-82.
2004: Chengzhen Ren; Likun Li; Guang Yang; Terry L Timme; Alexei Goltsov; Chenghui Ren; Xiaorong Ji; Josephine Addai; Hongbin Luo; Michael Ittmann; Timothy C Thompson
RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer.
Cancer research 2004;64(3):969-76.
2003: Likun Li; Cheng Hui Ren; Salahaldin A Tahir; Chengzhen Ren; Timothy C Thompson
Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A.
Molecular and cellular biology 2003;23(24):9389-404.
2003: Takefumi Satoh; Takashi Saika; Shin Ebara; Nobuyuki Kusaka; Terry L Timme; Guang Yang; Jianxiang Wang; Vladimir Mouraviev; Guangwen Cao; El Moataz Abdel Fattah; Timothy C Thompson
Macrophages transduced with an adenoviral vector expressing interleukin 12 suppress tumor growth and metastasis in a preclinical metastatic prostate cancer model.
Cancer research 2003;63(22):7853-60.
2003: Salahaldin A Tahir; Chengzhen Ren; Terry L Timme; Yehoshua Gdor; Ron C Hoogeveen; Joel D Morrisett; Anna Frolov; Gustavo Ayala; Thomas M Wheeler; Timothy C Thompson
Development of an immunoassay for serum caveolin-1: a novel biomarker for prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3653-9.
2003: Tiejun Zhao; Xiao-Mei Rao; Xiaoming Xie; Ling Li; Timothy C Thompson; Kelly M McMasters; Heshan Sam Zhou
Adenovirus with insertion-mutated E1A selectively propagates in liver cancer cells and destroys tumors in vivo.
Cancer research 2003;63(12):3073-8.
2003: Guangwen Cao; Guang Yang; Terry L Timme; Takashi Saika; Luan D Truong; Takefumi Satoh; Alexei Goltsov; Sang Hee Park; Taoyan Men; Nobuyuki Kusaka; Weihua Tian; Chengzhen Ren; Hongyu Wang; Dov Kadmon; Wei-Wen Cai; A Craig Chinault; Timothy B Boone; Allan Bradley; Timothy C Thompson
Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis.
The American journal of pathology 2003;162(4):1241-8.
2003: Terry L Timme; Takefumi Satoh; Salahaldin A Tahir; Hongyu Wang; Bin S Teh; E. Brian Butler; Brian J Miles; Robert J Amato; Dov Kadmon; Timothy C Thompson
Therapeutic targets for metastatic prostate cancer.
Current drug targets 2003;4(3):251-61.
2003: Takefumi Satoh; Guang Yang; Shin Egawa; Josephine Addai; Anna Frolov; Sadahito Kuwao; Terry L Timme; Shiro Baba; Timothy C Thompson
Caveolin-1 expression is a predictor of recurrence-free survival in pT2N0 prostate carcinoma diagnosed in Japanese patients.
Cancer 2003;97(5):1225-33.
2003: Takefumi Satoh; Terry L Timme; Takashi Saika; Shin Ebara; Guang Yang; Jianxiang Wang; Chengzhen Ren; Nobuyuki Kusaka; Vladimir Mouraviev; Timothy C Thompson
Adenoviral vector-mediated mRTVP-1 gene therapy for prostate cancer.
Human gene therapy 2003;14(2):91-101.
2002: Guang Yang; Gustavo Ayala; Angelo M DeMarzo; Weihua Tian; Anna Frolov; Thomas M Wheeler; Timothy C Thompson; J Wade Harper
Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3419-26.
2002: Vladimir Mouraviev; Likun Li; Salahaldin A Tahir; Guang Yang; Terry M Timme; Alexei Goltsov; Chengzhen Ren; Takefumi Satoh; Thomas M Wheeler; Michael Ittmann; Brian J Miles; Robert J Amato; Dov Kadmon; Timothy C Thompson
The role of caveolin-1 in androgen insensitive prostate cancer.
The Journal of urology 2002;168(4 Pt 1):1589-96.
2002: Maria T Vlachaki; Andres Hernandez-Garcia; Michael Ittmann; Madhu Chhikara; Laura K Aguilar; Xiaohong Zhu; Bin S Teh; E. Brian Butler; Shiao Woo; Timothy C Thompson; Hugo Barrera-Saldana; Estuardo Aguilar-Cordova; Bin S The
Impact of preimmunization on adenoviral vector expression and toxicity in a subcutaneous mouse cancer model.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(3):342-8.
2002: Yehoshua Gdor; Terry L Timme; Brian J Miles; Dov Kadmon; Timothy C Thompson
Gene therapy for prostate cancer.
Expert review of anticancer therapy 2002;2(3):309-21.
2002: Chengzhen Ren; Likun Li; Alexei Goltsov; Terry L Timme; Salahaldin A Tahir; Jianxiang Wang; Laura Garza; A Craig Chinault; Timothy C Thompson
mRTVP-1, a novel p53 target gene with proapoptotic activities.
Molecular and cellular biology 2002;22(10):3345-57.
2002: Shin Ebara; S Shimura; Yasutomo Nasu; Haruki Kaku; Hiromi Kumon; Guang Yang; Jianxiang Wang; Terry L Timme; Estuardo Aguilar-Cordova; Timothy C Thompson
Gene therapy for prostate cancer: toxicological profile of four HSV-tk transducing adenoviral vectors regulated by different promoters.
Prostate cancer and prostatic diseases 2002;5(4):316-25.
2002: Bin S Teh; Estuardo Aguilar-Cordova; Maria T Vlachaki; Laura K Aguilar; Wei-Yuan Mai; James Caillouet; Maria Davis; Brian J Miles; Dov Kadmon; Gustavo Ayala; Hsin H Lu; J Kam Chiu; L Steven Carpenter; Shiao Y Woo; Walter H Grant; Thomas Wheeler; Timothy C Thompson; E. Brian Butler
Combining radiotherapy with gene therapy (from the bench to the bedside): a novel treatment strategy for prostate cancer.
The oncologist 2002;7(5):458-66.
2001: Christins K Pramudji; S Shimura; Shin Ebara; Guang Yang; Jianxiang Wang; Chengzhen Ren; Y Yuan; Salahaldin A Tahir; Terry L Timme; Timothy C Thompson
In situ prostate cancer gene therapy using a novel adenoviral vector regulated by the caveolin-1 promoter.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(12):4272-9.
2001: Maria T Vlachaki; Madhu Chhikara; Laura K Aguilar; Xiaohong Zhu; K J Chiu; Shiao Woo; Bin S Teh; Timothy C Thompson; E. Brian Butler; Estuardo Aguilar-Cordova
Enhanced therapeutic effect of multiple injections of HSV-TK + GCV gene therapy in combination with ionizing radiation in a mouse mammary tumor model.
International journal of radiation oncology, biology, physics 2001;51(4):1008-17.
2001: Brian J Miles; Moshe Shalev; Estuardo Aguilar-Cordova; Terry L Timme; H M Lee; Guang Yang; HL Adler; Kenneth Kernen; Christins K Pramudji; Takefumi Satoh; Yehoshua Gdor; Chengzhen Ren; Gustavo Ayala; Thomas M Wheeler; E. Brian Butler; Dov Kadmon; Timothy C Thompson
Prostate-specific antigen response and systemic T cell activation after in situ gene therapy in prostate cancer patients failing radiotherapy.
Human gene therapy 2001;12(16):1955-67.
2001: Y Cabeza-Arvelaiz; Timothy C Thompson; Jorge L Sepulveda; A Craig Chinault
LAPSER1: a novel candidate tumor suppressor gene from 10q24.3.
Oncogene 2001;20(46):6707-17.
2001: Y Cabeza-Arvelaiz; Jorge L Sepulveda; RM Lebovitz; Timothy C Thompson; A Craig Chinault
Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22.
Oncogene 2001;20(31):4169-79.
2001: Likun Li; Guang Yang; Shin Ebara; Takefumi Satoh; Yasutomo Nasu; Terry L Timme; Chengzhen Ren; Jianxiang Wang; Salahaldin A Tahir; Timothy C Thompson
Caveolin-1 mediates testosterone-stimulated survival/clonal growth and promotes metastatic activities in prostate cancer cells.
Cancer research 2001;61(11):4386-92.
2001: Salahaldin A Tahir; Guang Yang; Shin Ebara; Terry L Timme; Takefumi Satoh; Likun Li; Alexei Goltsov; Michael Ittmann; Joel D Morrisett; Timothy C Thompson
Secreted caveolin-1 stimulates cell survival/clonal growth and contributes to metastasis in androgen-insensitive prostate cancer.
Cancer research 2001;61(10):3882-5.
2001: Madhu Chhikara; H Huang; Maria T Vlachaki; Xiaohong Zhu; B Teh; K J Chiu; Shiao Woo; B Berner; E O Smith; Kerby Oberg; Laura K Aguilar; Timothy C Thompson; E. Brian Butler; Estuardo Aguilar-Cordova
Enhanced therapeutic effect of HSV-tk+GCV gene therapy and ionizing radiation for prostate cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(4):536-42.
2001: S W Sukin; Madhu Chhikara; Xiaohong Zhu; Gustavo Ayala; Laura K Aguilar; E O'Brian Smith; Brian J Miles; Timothy C Thompson; Dov Kadmon; Estuardo Aguilar-Cordova
In vivo surgical resection plus adjuvant gene therapy in the treatment of mammary and prostate cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(4):500-6.
2001: Moshe Shalev; Timothy C Thompson; Dov Kadmon; Gustavo Ayala; Kenneth Kernen; Brian J Miles
Gene therapy for prostate cancer.
Urology 2001;57(1):8-16.
2000: Christina Thaller; M Shalev; A Frolov; Gregor Eichele; Timothy C Thompson; R H Williams; O Dillioglugil; Dov Kadmon
Fenretinide therapy in prostate cancer: effects on tissue and serum retinoid concentration.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(22):3804-8.
2000: S Shimura; Guang Yang; Shin Ebara; Thomas M Wheeler; Anna Frolov; Timothy C Thompson
Reduced infiltration of tumor-associated macrophages in human prostate cancer: association with cancer progression.
Cancer research 2000;60(20):5857-61.
2000: G W Hull; MA McCurdy; Yasutomo Nasu; CH Bangma; Guang Yang; S Shimura; H M Lee; Jianxiang Wang; J Albani; Shin Ebara; T Sato; Terry L Timme; Timothy C Thompson
Prostate cancer gene therapy: comparison of adenovirus-mediated expression of interleukin 12 with interleukin 12 plus B7-1 for in situ gene therapy and gene-modified, cell-based vaccines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(10):4101-9.
2000: M Shalev; Timothy C Thompson; A Frolov; S M Lippman; Waun Ki Hong; H Fritsche; D Kadmon
Effect of 13-cis-retinoic acid on serum prostate-specific antigen levels in patients with recurrent prostate cancer after radical prostatectomy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(10):3845-9.
2000: Guang Yang; Josephine Addai; Michael Ittmann; Thomas M Wheeler; Timothy C Thompson
Elevated caveolin-1 levels in African-American versus white-American prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(9):3430-3.
2000: Terry L Timme; Alexei Goltsov; Salahaldin A Tahir; Likun Li; Jianxiang Wang; Chengzhen Ren; Randal Johnston; Timothy C Thompson
Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis.
Oncogene 2000;19(29):3256-65.
2000: Gustavo Ayala; Thomas M Wheeler; Moshe Shalev; Timothy C Thompson; Brian J Miles; Estuardo Aguilar-Cordova; S Chakraborty; Dov Kadmon
Cytopathic effect of in situ gene therapy in prostate cancer.
Human pathology 2000;31(7):866-70.
2000: Timothy C Thompson; Terry L Timme; SH Park; G Yang; Chengxi Ren
Mouse prostate reconstitution model system: A series of in vivo and in vitro models for benign and malignant prostatic disease.
The Prostate 2000;43(4):248-54.
2000: Moshe Shalev; Dov Kadmon; Bin S Teh; E. Brian Butler; Estuardo Aguilar-Cordova; Timothy C Thompson; JR Herman; HL Adler; Peter T Scardino; Brian J Miles
Suicide gene therapy toxicity after multiple and repeat injections in patients with localized prostate cancer.
The Journal of urology 2000;163(6):1747-50.
2000: Bernard Kwabi-Addo; Timothy C Thompson; Michael Ittmann
Absence of PTEN/MMAC1 pseudogene in mice.
DNA and cell biology 2000;19(5):301-5.
2000: L Stepanova; G Yang; Francesco DeMayo; T M Wheeler; Milton Finegold; Timothy C Thompson; J Wade Harper
Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia.
Oncogene 2000;19(18):2186-93.
2000: Moshe Shalev; Brian J Miles; Timothy C Thompson; Gustavo Ayala; E. Brian Butler; Estuardo Aguilar-Cordova; Dov Kadmon
Suicide gene therapy for prostate cancer using a replication-deficient adenovirus containing the herpesvirus thymidine kinase gene.
World journal of urology 2000;18(2):125-9.
2000: H M Lee; Terry L Timme; Timothy C Thompson
Resistance to lysis by cytotoxic T cells: a dominant effect in metastatic mouse prostate cancer cells.
Cancer research 2000;60(7):1927-33.
2000: M R Shaker; G Yang; Terry L Timme; S H Park; Dov Kadmon; C Ren; X Ji; H M Lee; I Sehgal; M Anzano; Michael B. Sporn; Timothy C Thompson
Dietary 4-HPR suppresses the development of bone metastasis in vivo in a mouse model of prostate cancer progression.
Clinical & experimental metastasis 2000;18(5):429-38.
2000: Timothy C Thompson; G Yang
Regulation of apoptosis in prostatic disease.
The Prostate. Supplement 2000;9():25-8.
2000: Y Lotan; X C Xu; M Shalev; R Lotan; R Williams; Thomas M Wheeler; Timothy C Thompson; Dov Kadmon
Differential expression of nuclear retinoid receptors in normal and malignant prostates.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(1):116-21.
1999: Guang Yang; Luan D Truong; Thomas M Wheeler; Timothy C Thompson
Caveolin-1 expression in clinically confined human prostate cancer: a novel prognostic marker.
Cancer research 1999;59(22):5719-23.
1999: Timothy C Thompson; Terry L Timme; Likun Li; Alexei Goltsov
Caveolin-1, a metastasis-related gene that promotes cell survival in prostate cancer.
Apoptosis : an international journal on programmed cell death 1999;4(4):233-7.
1999: CH Bangma; Yasutomo Nasu; Chengzhen Ren; Timothy C Thompson
Metastasis-related genes in prostate cancer.
Seminars in oncology 1999;26(4):422-7.
1999: Sibel Erdamar; Guang Yang; J Wade Harper; X Lu; Michael W Kattan; Timothy C Thompson; Thomas M Wheeler
Levels of expression of p27KIP1 protein in human prostate and prostate cancer: an immunohistochemical analysis.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1999;12(8):751-5.
1999: JR Herman; HL Adler; Estuardo Aguilar-Cordova; A Rojas-Martinez; Shiao Woo; Terry L Timme; Thomas M Wheeler; Timothy C Thompson; Peter T Scardino
In situ gene therapy for adenocarcinoma of the prostate: a phase I clinical trial.
Human gene therapy 1999;10(7):1239-49.
1999: Yasutomo Nasu; CH Bangma; G W Hull; H M Lee; J Hu; Jianxiang Wang; MA McCurdy; S Shimura; Guang Yang; Terry L Timme; Timothy C Thompson
Adenovirus-mediated interleukin-12 gene therapy for prostate cancer: suppression of orthotopic tumor growth and pre-established lung metastases in an orthotopic model.
Gene therapy 1999;6(3):338-49.
1999: I Sehgal; Timothy C Thompson
Novel regulation of type IV collagenase (matrix metalloproteinase-9 and -2) activities by transforming growth factor-beta1 in human prostate cancer cell lines.
Molecular biology of the cell 1999;10(2):407-16.
1999: Timothy C Thompson
In situ gene therapy for prostate cancer.
Oncology research 1999;11(1):1-8.
1999: SJ Hall; Steven E Mutchnik; Guang Yang; Terry L Timme; Yasutomo Nasu; CH Bangma; SL Woo; M Shaker; Timothy C Thompson
Cooperative therapeutic effects of androgen ablation and adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy in experimental prostate cancer.
Cancer gene therapy 1999;6(1):54-63.
1999: HL Adler; MA McCurdy; Michael W Kattan; Terry L Timme; Peter T Scardino; Timothy C Thompson
Elevated levels of circulating interleukin-6 and transforming growth factor-beta1 in patients with metastatic prostatic carcinoma.
The Journal of urology 1999;161(1):182-7.
1998: I Sehgal; Timothy C Thompson
Neuropeptides induce Mr 92,000 type IV collagenase (matrix metalloprotease-9) activity in human prostate cancer cell lines.
Cancer research 1998;58(19):4288-91.
1998: Yasutomo Nasu; Terry L Timme; Guang Yang; CH Bangma; Likun Li; Chengzhen Ren; Sang Hee Park; M DeLeon; Jianxiang Wang; Timothy C Thompson
Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells.
Nature medicine 1998;4(9):1062-4.
1998: Guang Yang; Luan D Truong; Terry L Timme; Chengzhen Ren; Thomas M Wheeler; Sang Hee Park; Yasutomo Nasu; CH Bangma; Michael W Kattan; Peter T Scardino; Timothy C Thompson
Elevated expression of caveolin is associated with prostate and breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(8):1873-80.
1998: Ori Hampel; Michael W Kattan; Guang Yang; Sigmund Haidacher; George Y Saleh; Timothy C Thompson; Thomas M Wheeler; Marco Marcelli
Quantitative immunohistochemical analysis of insulin-like growth factor binding protein-3 in human prostatic adenocarcinoma: a prognostic study.
The Journal of urology 1998;159(6):2220-5.
1998: Chengzhen Ren; Guang Yang; Terry L Timme; Thomas M Wheeler; Timothy C Thompson
Reduced lysyl oxidase messenger RNA levels in experimental and human prostate cancer.
Cancer research 1998;58(6):1285-90.
1998: Terry L Timme; SJ Hall; R Barrios; SL Woo; Estuardo Aguilar-Cordova; Timothy C Thompson
Local inflammatory response and vector spread after direct intraprostatic injection of a recombinant adenovirus containing the herpes simplex virus thymidine kinase gene and ganciclovir therapy in mice.
Cancer gene therapy 1998;5(2):74-82.
1998: Timothy C Thompson
Metastasis-related genes in prostate cancer: the role of caveolin-1.
Cancer metastasis reviews 1998;17(4):439-42.
1998: A M Stapleton; P Zbell; Michael W Kattan; Guang Yang; Thomas M Wheeler; Peter T Scardino; Timothy C Thompson
Assessment of the biologic markers p53, Ki-67, and apoptotic index as predictive indicators of prostate carcinoma recurrence after surgery.
Cancer 1998;82(1):168-75.
1997: G Yang; Terry L Timme; SH Park; X Wu; M G Wyllie; Timothy C Thompson
Transforming growth factor beta 1 transduced mouse prostate reconstitutions: II. Induction of apoptosis by doxazosin.
The Prostate 1997;33(3):157-63.
1997: G Yang; Terry L Timme; SH Park; Timothy C Thompson
Transforming growth factor beta 1 transduced mouse prostate reconstitutions: I. Induction of neuronal phenotypes.
The Prostate 1997;33(3):151-6.
1997: S J Hall; Timothy C Thompson
Spontaneous but not experimental metastatic activities differentiate primary tumor-derived vs metastasis-derived mouse prostate cancer cell lines.
Clinical & experimental metastasis 1997;15(6):630-8.
1997: A M Stapleton; Terry L Timme; Angelo E Gousse; Q F Li; A A Tobon; Michael W Kattan; Kevin Slawin; Thomas M Wheeler; Peter T Scardino; Timothy C Thompson
Primary human prostate cancer cells harboring p53 mutations are clonally expanded in metastases.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(8):1389-97.
1997: SJ Hall; Steven E Mutchnik; SH Chen; SL Woo; Timothy C Thompson
Adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy leads to systemic activity against spontaneous and induced metastasis in an orthotopic mouse model of prostate cancer.
International journal of cancer. Journal international du cancer 1997;70(2):183-7.
1996: Guang Yang; Thomas M Wheeler; Michael W Kattan; Peter T Scardino; Timothy C Thompson
Perineural invasion of prostate carcinoma cells is associated with reduced apoptotic index.
Cancer 1996;78(6):1267-71.
1996: A M Stapleton; R H Williams; Terry L Timme; Guang Yang; Luan D Truong; Timothy C Thompson
Human cytomegalovirus is not implicated in benign prostatic hyperplasia: a study using immunohistochemistry and the polymerase chain reaction.
The Journal of urology 1996;156(2 Pt 1):542-5.
1996: I Sehgal; P A Baley; Timothy C Thompson
Transforming growth factor beta1 stimulates contrasting responses in metastatic versus primary mouse prostate cancer-derived cell lines in vitro.
Cancer research 1996;56(14):3359-65.
1996: R H Williams; A M Stapleton; Guang Yang; Luan D Truong; E Rogers; Terry L Timme; Thomas M Wheeler; Peter T Scardino; Timothy C Thompson
Reduced levels of transforming growth factor beta receptor type II in human prostate cancer: an immunohistochemical study.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(4):635-40.
1996: Terry L Timme; Guang Yang; E Rogers; Dov Kadmon; J P Morganstern; S H Park; Timothy C Thompson
Retroviral transduction of transforming growth factor-beta1 induces pleiotropic benign prostatic growth abnormalities in mouse prostate reconstitutions.
Laboratory investigation; a journal of technical methods and pathology 1996;74(4):747-60.
1996: James A Eastham; SH Chen; I Sehgal; Guang Yang; Terry L Timme; S J Hall; SL Woo; Timothy C Thompson
Prostate cancer gene therapy: herpes simplex virus thymidine kinase gene transduction followed by ganciclovir in mouse and human prostate cancer models.
Human gene therapy 1996;7(4):515-23.
1996: Guang Yang; A M Stapleton; Thomas M Wheeler; Luan D Truong; Terry L Timme; Peter T Scardino; Timothy C Thompson
Clustered p53 immunostaining: a novel pattern associated with prostate cancer progression.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(2):399-401.
1995: James A Eastham; Luan D Truong; E Rogers; Michael W Kattan; K C Flanders; Peter T Scardino; Timothy C Thompson
Transforming growth factor-beta 1: comparative immunohistochemical localization in human primary and metastatic prostate cancer.
Laboratory investigation; a journal of technical methods and pathology 1995;73(5):628-35.
1995: James A Eastham; A M Stapleton; Angelo E Gousse; Terry L Timme; Guang Yang; Kevin Slawin; Thomas M Wheeler; Peter T Scardino; Timothy C Thompson
Association of p53 mutations with metastatic prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(10):1111-8.
1995: P A Baley; K Yoshida; W Qian; I Sehgal; Timothy C Thompson
Progression to androgen insensitivity in a novel in vitro mouse model for prostate cancer.
The Journal of steroid biochemistry and molecular biology 1995;52(5):403-13.
1995: Timothy C Thompson; S H Park; Terry L Timme; Chengzhen Ren; James A Eastham; Lawrence A Donehower; Allan Bradley; Dov Kadmon; Guang Yang
Loss of p53 function leads to metastasis in ras+myc-initiated mouse prostate cancer.
Oncogene 1995;10(5):869-79.
1995: Terry L Timme; Luan D Truong; Kevin Slawin; Dov Kadmon; S H Park; Timothy C Thompson
Mesenchymal-epithelial interactions and transforming growth factor-beta 1 expression during normal and abnormal prostatic growth.
Microscopy research and technique 1995;30(4):333-41.
1995: damian greene; S R Taylor; M Aihara; K Yoshida; S Egawa; S H Park; Terry L Timme; Guang Yang; Peter T Scardino; Timothy C Thompson
DNA ploidy and clonal selection in ras + myc-induced mouse prostate cancer.
International journal of cancer. Journal international du cancer 1995;60(3):395-9.
1995: M Aihara; Peter T Scardino; Luan D Truong; Thomas M Wheeler; J R Goad; Guang Yang; Timothy C Thompson
The frequency of apoptosis correlates with the prognosis of Gleason Grade 3 adenocarcinoma of the prostate.
Cancer 1995;75(2):522-9.
1995: Terry L Timme; G Yang; Luan D Truong; Dov Kadmon; S H Park; Timothy C Thompson
Transforming growth factor-beta localization during mouse prostate morphogenesis and in prostatic growth abnormalities.
World journal of urology 1995;13(6):324-8.
1994: Makoto Ohori; J R Goad; Thomas M Wheeler; James A Eastham; Timothy C Thompson; Peter T Scardino
Can radical prostatectomy alter the progression of poorly differentiated prostate cancer?
The Journal of urology 1994;152(5 Pt 2):1843-9.
1994: Terry L Timme; Timothy C Thompson
Rapid allelotype analysis of p53 knockout mice.
BioTechniques 1994;17(3):460, 462-3.
1994: M Aihara; Luan D Truong; J K Dunn; Thomas M Wheeler; Peter T Scardino; Timothy C Thompson
Frequency of apoptotic bodies positively correlates with Gleason grade in prostate cancer.
Human pathology 1994;25(8):797-801.
1994: damian greene; E Rogers; E C Wessels; Thomas M Wheeler; S R Taylor; Richard A Santucci; Timothy C Thompson; Peter T Scardino
Some small prostate cancers are nondiploid by nuclear image analysis: correlation of deoxyribonucleic acid ploidy status and pathological features.
The Journal of urology 1994;151(5):1301-7.
1994: Terry L Timme; Luan D Truong; V W Merz; T Krebs; Dov Kadmon; K C Flanders; S H Park; Timothy C Thompson
Mesenchymal-epithelial interactions and transforming growth factor-beta expression during mouse prostate morphogenesis.
Endocrinology 1994;134(3):1039-45.
1994: Thomas M Wheeler; E Rogers; M Aihara; Peter T Scardino; Timothy C Thompson
Apoptotic index as a biomarker in prostatic intraepithelial neoplasia (PIN) and prostate cancer.
Journal of cellular biochemistry. Supplement 1994;19():202-7.
1993: Kevin Slawin; Dov Kadmon; S H Park; Peter T Scardino; M Anzano; Michael B. Sporn; Timothy C Thompson
Dietary fenretinide, a synthetic retinoid, decreases the tumor incidence and the tumor mass of ras+myc-induced carcinomas in the mouse prostate reconstitution model system.
Cancer research 1993;53(19):4461-5.
1993: Timothy C Thompson; Luan D Truong; Terry L Timme; Dov Kadmon; B K McCune; K C Flanders; Peter T Scardino; S H Park
Transgenic models for the study of prostate cancer.
Cancer 1993;71(3 Suppl):1165-71.
1993: Timothy C Thompson; Terry L Timme; Dov Kadmon; S H Park; S Egawa; K Yoshida
Genetic predisposition and mesenchymal-epithelial interactions in ras+myc-induced carcinogenesis in reconstituted mouse prostate.
Molecular carcinogenesis 1993;7(3):165-79.
1993: Luan D Truong; Dov Kadmon; B K McCune; K C Flanders; Peter T Scardino; Timothy C Thompson
Association of transforming growth factor-beta 1 with prostate cancer: an immunohistochemical study.
Human pathology 1993;24(1):4-9.
1992: Timothy C Thompson; S Egawa; Dov Kadmon; G J Miller; Terry L Timme; Peter T Scardino; S H Park
Androgen sensitivity and gene expression in ras + myc-induced mouse prostate carcinomas.
The Journal of steroid biochemistry and molecular biology 1992;43(1-3):79-85.
1992: S Egawa; Dov Kadmon; G J Miller; Peter T Scardino; Timothy C Thompson
Alterations in mRNA levels for growth-related genes after transplantation into castrated hosts in oncogene-induced clonal mouse prostate carcinoma.
Molecular carcinogenesis 1992;5(1):52-61.
1992: Timothy C Thompson; Luan D Truong; Terry L Timme; Dov Kadmon; B K McCune; K C Flanders; Peter T Scardino; S H Park
Transforming growth factor beta 1 as a biomarker for prostate cancer.
Journal of cellular biochemistry. Supplement 1992;16H():54-61.
1991: Dov Kadmon; Timothy C Thompson; G R Lynch; Peter T Scardino
Elevated plasma chromogranin-A concentrations in prostatic carcinoma.
The Journal of urology 1991;146(2):358-61.
1991: V W Merz; G J Miller; T Krebs; Terry L Timme; Dov Kadmon; S H Park; S Egawa; Peter T Scardino; Timothy C Thompson
Elevated transforming growth factor-beta 1 and beta 3 mRNA levels are associated with ras + myc-induced carcinomas in reconstituted mouse prostate: evidence for a paracrine role during progression.
Molecular endocrinology (Baltimore, Md.) 1991;5(4):503-13.
1991: Timothy C Thompson; Dov Kadmon; Terry L Timme; V W Merz; S Egawa; T Krebs; Peter T Scardino; S H Park
Experimental oncogene induced prostate cancer.
Cancer surveys 1991;11():55-71.
1990: Timothy C Thompson
Growth factors and oncogenes in prostate cancer.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1990;2(11):345-54.