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Angus Thomson

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Brian R Rosborough; Heth R Turnquist; Mark Boothby; Ronald A DePinho; Boyi Gan; Holger Hackstein; Keunwook Lee; Benjamin M Matta; Dàlia Raïch-Regué; Angus W Thomson
Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction.
N M Rogers; J S Isenberg; Angus W Thomson
Plasmacytoid dendritic cells: no longer an enigma and now key to transplant tolerance?
Matthew Zhang; Donna B Stolz; Antonino Castellaneta; Anthony J Demetris; David A Geller; Shoko Kimura; Kikumi S Ozaki; Mark Ross; Angus W Thomson; Shinya Ueki; Yoram Vodovotz; Osamu Yoshida; Noriko Murase
Roles of dendritic cells in murine hepatic warm and liver transplantation-induced cold ischemia/reperfusion injury.

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2013: Brian R Rosborough; Heth R Turnquist; Mark Boothby; Ronald A DePinho; Boyi Gan; Holger Hackstein; Keunwook Lee; Benjamin M Matta; Dàlia Raïch-Regué; Angus W Thomson
Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction.
Blood 2013;121(18):3619-30.
2013: N M Rogers; J S Isenberg; Angus W Thomson
Plasmacytoid dendritic cells: no longer an enigma and now key to transplant tolerance?
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013;13(5):1125-33.
2013: Matthew Zhang; Donna B Stolz; Antonino Castellaneta; Anthony J Demetris; David A Geller; Shoko Kimura; Kikumi S Ozaki; Mark Ross; Angus W Thomson; Shinya Ueki; Yoram Vodovotz; Osamu Yoshida; Noriko Murase
Roles of dendritic cells in murine hepatic warm and liver transplantation-induced cold ischemia/reperfusion injury.
Hepatology (Baltimore, Md.) 2013;57(4):1585-96.
2013: Adrian E Morelli; Angus W Thomson
Galectin-1, immune regulation and liver allograft survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013;13(3):535-6.
2012: Brian P Hermann; Joseph E Kiss; Maura Lienesch; Keith Masterson; Shoukhrat Mitalipov; David K Cooper; Gina Dargo; Mohamed Ezzelarab; Julia N Pascarella; Maria Cecilia T Penedo; Karen A Peters; Kim Peterson; Cathy Ramsey; Mario Rodriguez; Gerald P Schatten; Yi Sheng; Meena Sukhwani; Angus W Thomson; Hanna Valli; Angie Volk; Thea Ward; Felicity Winkler; Kyle E Orwig
Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm.
Cell stem cell 2012;11(5):715-26.
2012: Tina L Sumpter; Angus W Thomson; Yoram Vodovotz; Anil Dangi; Chao Huang; Benjamin M Matta; Donna B Stolz; Chandrashekhar R Gandhi
Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(8):3848-58.
2012: Rodolfo D Vicetti Miguel; Alfredo J Aguirre; Stephen Alan Harvey; Robert L Hendricks; Melissa A Melan; Anthony J St Leger; Tracy Terry-Allison; Angus W Thomson; Thomas L Cherpes
Dendritic cell activation and memory cell development are impaired among mice administered medroxyprogesterone acetate prior to mucosal herpes simplex virus type 1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(7):3449-61.
2012: Siddharth Jhunjhunwala; Andrew J Glowacki; Sherri J Hall; Dan Maskarinec; Giorgio Raimondi; Angus W Thomson; Stephen H Thorne; Steven R Little
Bioinspired controlled release of CCL22 recruits regulatory T cells in vivo.
Advanced materials (Deerfield Beach, Fla.) 2012;24(35):4735-8.
2012: Natasha M Rogers; Angus W Thomson; Jeffrey S Isenberg
Activation of parenchymal CD47 promotes renal ischemia-reperfusion injury.
Journal of the American Society of Nephrology : JASN 2012;23(9):1538-50.
2012: Benjamin M Matta; Giorgio Raimondi; Brian R Rosborough; Tina L Sumpter; Angus W Thomson
IL-27 production and STAT3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(11):5227-37.
2012: Elizabeth O Stenger; Markus Y Mapara; Heth R Turnquist; Angus W Thomson
Dendritic cells and regulation of graft-versus-host disease and graft-versus-leukemia activity.
Blood 2012;119(22):5088-103.
2012: Brian R Rosborough; Angus W Thomson; Antonino Castellaneta; Sudha Natarajan; Heth R Turnquist
Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo.
Journal of leukocyte biology 2012;91(5):701-9.
2012: Anil Dangi; Chao Huang; Shoko Kimura; Noriko Murase; Giorgio Raimondi; Donna B Stolz; Tina L Sumpter; Angus W Thomson; Yoram Vodovotz; Chandrashekhar R Gandhi
Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(8):3667-77.
2012: Siddharth Jhunjhunwala; Stephen C Balmert; Eefje Dons; Erin E Nichols; Giorgio Raimondi; Angus W Thomson; Steven R Little
Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells.
Journal of controlled release : official journal of the Controlled Release Society 2012;159(1):78-84.
2012: Eefje M Dons; Giorgio Raimondi; David K C Cooper; Angus W Thomson
Induced regulatory T cells: mechanisms of conversion and suppressive potential.
Human immunology 2012;73(4):328-34.
2012: Camila Macedo; Diana Metes; Hēth Turquist; Angus W Thomson
Immunoregulatory properties of rapamycin-conditioned monocyte-derived dendritic cells and their role in transplantation.
Transplantation research 2012;1(1):16.
2012: Paul Szabolcs; William J Burlingham; Angus W Thomson
Tolerance after solid organ and hematopoietic cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012;18(1 Suppl):S193-200.
2011: Heth R Turnquist; Zhiliang Wang; Kathryn J Wood; Zhenlin Zhao; Xin Xiao Zheng; Donna Beer-Stolz; Antonino Castellaneta; A Jake Demetris; Kumiko Isse; Megan Lang; Foo Y Liew; Quan Liu; Brian R Rosborough; Angus W Thomson
IL-33 expands suppressive CD11b+ Gr-1(int) and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(9):4598-610.
2011: Mohamed Ezzelarab; Angus W Thomson
Tolerogenic dendritic cells and their role in transplantation.
Seminars in immunology 2011;23(4):252-63.
2011: Angus W Thomson; A Jake Demetris; Chandrashekhar Gandhi; David A Geller; Noriko Murase; Donna Beer-Stolz
Hepatic antigen-presenting cells and regulation of liver transplant outcome.
Immunologic research 2011;50(2-3):221-7.
2011: Ryan T Fischer; Heth R Turnquist; Zhiliang Wang; Donna Beer-Stolz; Angus W Thomson
Rapamycin-conditioned, alloantigen-pulsed myeloid dendritic cells present donor MHC class I/peptide via the semi-direct pathway and inhibit survival of antigen-specific CD8(+) T cells in vitro and in vivo.
Transplant immunology 2011;25(1):20-6.
2011: Shinya Ueki; Osamu Yoshida; Matthew Zhang; Antonino Castellaneta; Anthony J Demetris; David A Geller; Kumiko Isse; Shoko Kimura; Kikumi Ozaki; Mark Ross; Lifang Shao; Donna B Stolz; Angus W Thomson; Noriko Murase
Hepatic B7 homolog 1 expression is essential for controlling cold ischemia/reperfusion injury after mouse liver transplantation.
Hepatology (Baltimore, Md.) 2011;54(1):216-28.
2011: Tina L Sumpter; Vignesh Packiam; Heth R Turnquist; Antonino Castellaneta; Osamu Yoshida; Angus W Thomson
DAP12 promotes IRAK-M expression and IL-10 production by liver myeloid dendritic cells and restrains their T cell allostimulatory ability.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):1970-80.
2011: Tina L Sumpter; Angus W Thomson
The STATus of PD-L1 (B7-H1) on tolerogenic APCs.
European journal of immunology 2011;41(2):286-90.
2010: Angus W Thomson; Percy A Knolle
Antigen-presenting cell function in the tolerogenic liver environment.
Nature reviews. Immunology 2010;10(11):753-66.
2010: Benjamin M Matta; Antonino Castellaneta; Angus W Thomson
Tolerogenic plasmacytoid DC.
European journal of immunology 2010;40(10):2667-76.
2010: Sudha Natarajan; Angus W Thomson
Tolerogenic dendritic cells and myeloid-derived suppressor cells: potential for regulation and therapy of liver auto- and alloimmunity.
Immunobiology 2010;215(9-10):698-703.
2010: Heth R Turnquist; Jon Cardinal; Camila Macedo; Brian R Rosborough; Tina L Sumpter; David A Geller; Diana Metes; Angus W Thomson
mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS.
Blood 2010;115(23):4758-69.
2010: Alin Girnita; George V Mazariegos; Antonino Castellaneta; Jorge Reyes; Carol Bentlejewski; Angus W Thomson; Adriana Zeevi
Liver transplant recipients weaned off immunosuppression lack circulating donor-specific antibodies.
Human immunology 2010;71(3):274-6.
2010: Angus W Thomson
Tolerogenic dendritic cells: all present and correct?
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(2):214-9.
2010: Jignesh V Unadkat; Stefan Schneeberger; E H Horibe; C Goldbach; M G Solari; K M Washington; V S Gorantla; G M Cooper; Angus W Thomson; W P Andrew Lee
Composite tissue vasculopathy and degeneration following multiple episodes of acute rejection in reconstructive transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(2):251-61.
2010: Antonino Castellaneta; Angus W Thomson; Navdeep Nayyar; Michael de Vera; George V Mazariegos
Monitoring the operationally tolerant liver allograft recipient.
Current opinion in organ transplantation 2010;15(1):28-34.
2010: Ankit Gupta; Chethan Ashokkumar; Mylarappa Ningappa; Qing Sun; Brandon W Higgs; Sara Snyder; Matthew Johnson; Adriana Zeevi; Kareem M Abu-Elmagd; Angus W Thomson; George V Mazariegos; Rakesh Sindhi
Elevated myeloid: plasmacytoid dendritic cell ratio associates with early acute cellular rejection in pediatric small bowel transplantation.
Transplantation 2010;89(1):55-60.
2010: Giorgio Raimondi; Tina L Sumpter; Benjamin M Matta; Mahesh Pillai; Natasha Corbitt; Yoram Vodovotz; Zhiliang Wang; Angus W Thomson
Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(2):624-36.
2010: Heth R Turnquist; Ryan T Fischer; Angus W Thomson
Pharmacological modification of dendritic cells to promote their tolerogenicity in transplantation.
Methods in molecular biology (Clifton, N.J.) 2010;595():135-48.
2009: Antonino Castellaneta; Tina L Sumpter; Lieping Chen; Daisuke Tokita; Angus W Thomson
NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7-H1 up-regulation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):6922-32.
2009: Heth R Turnquist; Angus W Thomson
IL-33 broadens its repertoire to affect DC.
European journal of immunology 2009;39(12):3292-5.
2009: Alan F Zahorchak; Giorgio Raimondi; Angus W Thomson
Rhesus monkey immature monocyte-derived dendritic cells generate alloantigen-specific regulatory T cells from circulating CD4+CD127-/lo T cells.
Transplantation 2009;88(9):1057-64.
2009: Ankit Gupta; Chethan Ashok Kumar; Mylarappa Ningappa; Qing Sun; Brandon W Higgs; Sara Snyder; Adriana Zeevi; Angus W Thomson; George V Mazariegos; Rakesh Sindhi
Elevated myeloid: plasmacytoid dendritic cell ratio associates with late, but not early, liver rejection in children induced with rabbit anti-human thymocyte globulin.
Transplantation 2009;88(4):589-94.
2009: Tina L Sumpter; John G Lunz; A Jake Demetris; Angus W Thomson
Molecular regulation of hepatic dendritic cell function and its relation to liver transplant outcome.
Transplantation 2009;88(3 Suppl):S40-4.
2009: Angus W Thomson; Heth R Turnquist; Alan F Zahorchak; Giorgio Raimondi
Tolerogenic dendritic cell-regulatory T-cell interaction and the promotion of transplant tolerance.
Transplantation 2009;87(9 Suppl):S86-90.
2009: Angus W Thomson; Heth R Turnquist; Giorgio Raimondi
Immunoregulatory functions of mTOR inhibition.
Nature reviews. Immunology 2009;9(5):324-37.
2009: Bridget L Colvin; Tina L Sumpter; Daisuke Tokita; Jennifer Salati; Andrew L Mellor; Angus W Thomson
Allostimulatory activity of bone marrow-derived plasmacytoid dendritic cells is independent of indoleamine dioxygenase but regulated by inducible costimulator ligand expression.
Human immunology 2009;70(5):313-20.
2009: Angus W Thomson; Justin M Sacks; Yur-Ren Kuo; R Ikeguchi; Elaine Kawano Horibe; Jignesh V Unadkat; M G Solari; Maryam Feili-Hariri; W P Andrew Lee
Dendritic cell therapy in composite tissue allotransplantation.
Transplantation proceedings 2009;41(2):537-8.
2009: S Jhunjhunwala; G Raimondi; Angus W Thomson; S R Little
Delivery of rapamycin to dendritic cells using degradable microparticles.
Journal of controlled release : official journal of the Controlled Release Society 2009;133(3):191-7.
2009: Mario G Solari; Kia M Washington; Justin M Sacks; Theresa Hautz; Jignesh V Unadkat; Elaine K Horibe; Raman Venkataramanan; Adriana T Larregina; Angus W Thomson; W P Andrew Lee
Daily topical tacrolimus therapy prevents skin rejection in a rodent hind limb allograft model.
Plastic and reconstructive surgery 2009;123(2 Suppl):17S-25S.
2009: Tina L Sumpter; John G Lunz; Antonino Castellaneta; Benjamin Matta; Daisuke Tokita; Heth R Turnquist; George V Mazariegos; A Jake Demetris; Angus W Thomson
Dendritic cell immunobiology in relation to liver transplant outcome.
Frontiers in bioscience (Elite edition) 2009;1():99-114.
2009: Audrey H Lau; Gyongyi Szabo; Angus W Thomson
Antigen-presenting cells under the influence of alcohol.
Trends in immunology 2009;30(1):13-22.
2009: Ryan Fischer; Heth R Turnquist; Timuçin Taner; Angus W Thomson
Use of rapamycin in the induction of tolerogenic dendritic cells.
Handbook of experimental pharmacology 2009;(188):215-32.
2009: Anthony J Demetris; John G Lunz; Parmjeet Randhawa; Tong Wu; Michael Nalesnik; Angus W Thomson
Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspective.
Transplant international : official journal of the European Society for Organ Transplantation 2009;22(1):120-41.
2008: Daisuke Tokita; Tina L Sumpter; Giorgio Raimondi; Alan F Zahorchak; Zhiliang Wang; Atsunori Nakao; George V Mazariegos; Masanori Abe; Angus W Thomson
Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells.
Journal of hepatology 2008;49(6):1008-18.
2008: Yuk Yuen Lan; Daisuke Tokita; Zhiliang Wang; Hao Chen Wang; Jianghua Zhan; Volker Brinkmann; Angus W Thomson
Sphingosine 1-phosphate receptor agonism impairs skin dendritic cell migration and homing to secondary lymphoid tissue: association with prolonged allograft survival.
Transplant immunology 2008;20(1-2):88-94.
2008: Heth R Turnquist; Angus W Thomson
Taming the lions: manipulating dendritic cells for use as negative cellular vaccines in organ transplantation.
Current opinion in organ transplantation 2008;13(4):350-7.
2008: Heth R Turnquist; Tina L Sumpter; Allan Tsung; Alan F Zahorchak; Atsunori Nakao; Gerard J Nau; Foo Y Liew; David A Geller; Angus W Thomson
IL-1beta-driven ST2L expression promotes maturation resistance in rapamycin-conditioned dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):62-72.
2008: Mario G Solari; Angus W Thomson
Human dendritic cells and transplant outcome.
Transplantation 2008;85(11):1513-22.
2008: Daisuke Tokita; George V Mazariegos; Alan F Zahorchak; Nydia Chien; Masanori Abe; Giorgio Raimondi; Angus W Thomson
High PD-L1/CD86 ratio on plasmacytoid dendritic cells correlates with elevated T-regulatory cells in liver transplant tolerance.
Transplantation 2008;85(3):369-77.
2008: Elaine K Horibe; Justin M Sacks; Jignesh V Unadkat; Giorgio Raimondi; Zhiliang Wang; Ryosuke Ikeguchi; Douglas Marsteller; Lydia M Ferreira; Angus W Thomson; W P Andrew Lee; Maryam Feili-Hariri
Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion.
Transplant immunology 2008;18(4):307-18.
2008: Ryosuke Ikeguchi; Justin M Sacks; Jignesh V Unadkat; Mario Solari; Elaine Kawano Horibe; Angus W Thomson; Andrew W P Lee; Maryam Feili-Hariri
Long-term survival of limb allografts induced by pharmacologically conditioned, donor alloantigen-pulsed dendritic cells without maintenance immunosuppression.
Transplantation 2008;85(2):237-46.
2008: Justin M Sacks; Yur-Ren Kuo; Aurèle Taieb; Jeremy Breitinger; Vu T Nguyen; Angus W Thomson; Maryam Feili-Hariri; W P Andrew Lee
Prolongation of composite tissue allograft survival by immature recipient dendritic cells pulsed with donor antigen and transient low-dose immunosuppression.
Plastic and reconstructive surgery 2008;121(1):37-49.
2007: Tina L Sumpter; Masanori Abe; Daisuke Tokita; Angus W Thomson
Dendritic cells, the liver, and transplantation.
Hepatology (Baltimore, Md.) 2007;46(6):2021-31.
2007: Sandra M Blois; Ulrike Kammerer; Catalina D Alba Soto; Mareike Tometten; Valerie Shaikly; Gabriela Barrientos; Richard Jurd; Daniel Rukavina; Angus W Thomson; Burghard F Klapp; Nelson Fernández; Petra C Arck
Dendritic cells: key to fetal tolerance?
Biology of reproduction 2007;77(4):590-8.
2007: Gordana Laskarin; Ulrike Kämmerer; Daniel Rukavina; Angus W Thomson; Nelson Fernandez; Sandra M Blois
Antigen-presenting cells and materno-fetal tolerance: an emerging role for dendritic cells.
American journal of reproductive immunology (New York, N.Y. : 1989) 2007;58(3):255-67.
2007: Jeffrey A Bluestone; Angus W Thomson; Ethan M Shevach; Howard L Weiner
What does the future hold for cell-based tolerogenic therapy?
Nature reviews. Immunology 2007;7(8):650-4.
2007: Adrian E Morelli; Angus W Thomson
Tolerogenic dendritic cells and the quest for transplant tolerance.
Nature reviews. Immunology 2007;7(8):610-21.
2007: Alan F Zahorchak; Leslie S Kean; Daisuke Tokita; Heth R Turnquist; Masanori Abe; Jennifer Finke; Kelly Hamby; Mark R Rigby; Christian P Larsen; Angus W Thomson
Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques.
Transplantation 2007;84(2):196-206.
2007: Audrey H Lau; Angus W Thomson; Bridget L Colvin
Chronic ethanol exposure affects in vivo migration of hepatic dendritic cells to secondary lymphoid tissue.
Human immunology 2007;68(7):577-85.
2007: Heth R Turnquist; Giorgio Raimondi; Alan F Zahorchak; Ryan T Fischer; Zhiliang Wang; Angus W Thomson
Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):7018-31.
2007: iulia popescu; Camila Macedo; Kareem Abu-Elmagd; Ron Shapiro; Y Hua; Angus W Thomson; Adrian E Morelli; Walter J Storkus; Diana Metes
EBV-specific CD8+ T cell reactivation in transplant patients results in expansion of CD8+ type-1 regulatory T cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(5):1215-23.
2007: Aurèle Taieb; Jeremy J Breitinger; Jignesh V Unadkat; William J Shufesky; Adrian E Morelli; Angus W Thomson; W P Andrew Lee; Maryam Feili-Hariri
Intrinsic ability of GM+IL-4 but not Flt3L-induced rat dendritic cells to promote allogeneic T cell hyporesponsiveness.
Clinical immunology (Orlando, Fla.) 2007;123(2):176-89.
2007: Holger Hackstein; C Steinschulte; S Fiedel; A Eisele; V Rathke; Thomas H W Stadlbauer; Timucin Taner; Angus W Thomson; Harald Tillmanns; Gregor Bein; Hans Hölschermann
Sanglifehrin a blocks key dendritic cell functions in vivo and promotes long-term allograft survival together with low-dose CsA.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(4):789-98.
2007: Adrian E Morelli; P Toby H Coates; William J Shufesky; Simon M Barratt-Boyes; John J Fung; Anthony J Demetris; Angus W Thomson
Growth factor-induced mobilization of dendritic cells in kidney and liver of rhesus macaques: implications for transplantation.
Transplantation 2007;83(5):656-62.
2007: Sistiana Aiello; Paola Cassis; linda cassis; Susanna Tomasoni; Ariela Benigni; Anna Pezzotta; Regiane A Cavinato; Daniela Cugini; Nadia Azzollini; Marilena Mister; Lorena Longaretti; Angus W Thomson; Giuseppe Remuzzi; Marina Noris
DnIKK2-transfected dendritic cells induce a novel population of inducible nitric oxide synthase-expressing CD4+CD25- cells with tolerogenic properties.
Transplantation 2007;83(4):474-84.
2007: George V Mazariegos; Rakesh Sindhi; Angus W Thomson; Amadeo Marcos
Clinical tolerance following liver transplantation: long term results and future prospects.
Transplant immunology 2007;17(2):114-9.
2007: Giorgio Raimondi; Heth R Turnquist; Angus W Thomson
Frontiers of immunological tolerance.
Methods in molecular biology (Clifton, N.J.) 2007;380():1-24.
2007: Giorgio Raimondi; Michael Turner; Angus W Thomson; Penelope A Morel
Naturally occurring regulatory T cells: recent insights in health and disease.
Critical reviews in immunology 2007;27(1):61-95.
2006: Yuk Yuen Lan; Zhiliang Wang; Giorgio Raimondi; Wenhan Wu; Bridget L Colvin; An De Creus; Angus W Thomson
"Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):5868-77.
2006: Masanori Abe; Daisuke Tokita; Giorgio Raimondi; Angus W Thomson
Endotoxin modulates the capacity of CpG-activated liver myeloid DC to direct Th1-type responses.
European journal of immunology 2006;36(9):2483-93.
2006: Angus W Thomson; R L Fairchild
The last 5 years of basic science investigation in transplant immunology.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(8):1768-73.
2006: Kenneth R McCurry; Bridget L Colvin; Alan F Zahorchak; Angus W Thomson
Regulatory dendritic cell therapy in organ transplantation.
Transplant international : official journal of the European Society for Organ Transplantation 2006;19(7):525-38.
2006: Marcelo J Perone; Adriana T Larregina; William J Shufesky; Glenn D Papworth; Mara L G Sullivan; Alan F Zahorchak; Donna B Stolz; Linda G Baum; simon simon watkins; Angus W Thomson; Adrian E Morelli
Transgenic galectin-1 induces maturation of dendritic cells that elicit contrasting responses in naive and activated T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7207-20.
2006: Zhiliang Wang; Adriana T Larregina; William J Shufesky; Marcelo J Perone; Angela Montecalvo; Alan F Zahorchak; Angus W Thomson; Adrian E Morelli
Use of the inhibitory effect of apoptotic cells on dendritic cells for graft survival via T-cell deletion and regulatory T cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(6):1297-311.
2006: Audrey H Lau; Masanori Abe; Angus W Thomson
Ethanol affects the generation, cosignaling molecule expression, and function of plasmacytoid and myeloid dendritic cell subsets in vitro and in vivo.
Journal of leukocyte biology 2006;79(5):941-53.
2006: Antonino Castellaneta; Alfredo Di Leo; Ruggiero Francavilla; Marcella Margiotta; Michele Barone; Annacinzia Amoruso; Laura Troiani; Angus W Thomson; Antonio Francavilla
Functional modification of CD11c+ liver dendritic cells during liver regeneration after partial hepatectomy in mice.
Hepatology (Baltimore, Md.) 2006;43(4):807-16.
2006: Mahyar Nouri-Shirazi; Angus W Thomson
Dendritic cells as promoters of transplant tolerance.
Expert opinion on biological therapy 2006;6(4):325-39.
2006: Giorgio Raimondi; William J Shufesky; Daisuke Tokita; Adrian E Morelli; Angus W Thomson
Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):2808-16.
2006: Masanori Abe; Angus W Thomson
Dexamethasone preferentially suppresses plasmacytoid dendritic cell differentiation and enhances their apoptotic death.
Clinical immunology (Orlando, Fla.) 2006;118(2-3):300-6.
2006: Atsunori Nakao; Hideyoshi Toyokawa; Masanori Abe; Tetsuma Kiyomoto; Kiichi Nakahira; Augustine M K Choi; Michael A Nalesnik; Angus W Thomson; Noriko Murase
Heart allograft protection with low-dose carbon monoxide inhalation: effects on inflammatory mediators and alloreactive T-cell responses.
Transplantation 2006;81(2):220-30.
2006: Wai H Lim; Svjetlana Kireta; Angus W Thomson; Graeme R Russ; P Toby H Coates
Renal transplantation reverses functional deficiencies in circulating dendritic cell subsets in chronic renal failure patients.
Transplantation 2006;81(2):160-8.
2005: Adrian E Morelli; J Peter Rubin; Geza Erdos; Olga A Tkacheva; Alicia R Mathers; Alan F Zahorchak; Angus W Thomson; Louis Falo; Adriana T Larregina
CD4+ T cell responses elicited by different subsets of human skin migratory dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):7905-15.
2005: Simon M Barratt-Boyes; Angus W Thomson
Dendritic cells: tools and targets for transplant tolerance.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(12):2807-13.
2005: M Abe; Bridget L Colvin; Angus W Thomson
Plasmacytoid dendritic cells: in vivo regulators of alloimmune reactivity?
Transplantation proceedings 2005;37(9):4119-21.
2005: Yuk Yuen Lan; An De Creus; Bridget L Colvin; Masanori Abe; Volker Brinkmann; P Toby H Coates; Angus W Thomson
The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(11):2649-59.
2005: Masanori Abe; Diana Metes; Angus W Thomson
Dendritic cells and regulation of alloimmune responses: relevance to outcome and therapy of organ transplantation.
Expert review of clinical immunology 2005;1(3):419-30.
2005: Bridget L Colvin; Zhiliang Wang; Hideki Nakano; WenHan Wu; Terutaka Kakiuchi; Robert L Fairchild; Angus W Thomson
CXCL9 antagonism further extends prolonged cardiac allograft survival in CCL19/CCL21-deficient mice.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(9):2104-13.
2005: Pia Björck; P Toby H Coates; Zhiliang Wang; F Jason Duncan; Angus W Thomson
Promotion of long-term heart allograft survival by combination of mobilized donor plasmacytoid dendritic cells and anti-CD154 monoclonal antibody.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2005;24(8):1118-20.
2005: Masanori Abe; Zhiliang Wang; An De Creus; Angus W Thomson
Plasmacytoid dendritic cell precursors induce allogeneic T-cell hyporesponsiveness and prolong heart graft survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(8):1808-19.
2005: Robert I Lechler; Megan Sykes; Angus W Thomson; Laurence A Turka
Organ transplantation--how much of the promise has been realized?
Nature medicine 2005;11(6):605-13.
2005: Zhiliang Wang; Timucin Taner; Adrian E Morelli; Angus W Thomson
Hosts lacking fms-like tyrosine kinase 3 ligand exhibit marked reductions in transplant vascular sclerosis.
Transplantation 2005;79(8):869-75.
2005: Camila Macedo; iulia popescu; Kareem Abu-Elmagd; Jorge Reyes; Ron Shapiro; Adriana Zeevi; Jan Mueller Berghaus; Lian Fu Wang; Lina Lu; Angus W Thomson; Walter J Storkus; John J Fung; Diana Metes
Augmentation of type-1 polarizing ability of monocyte-derived dendritic cells from chronically immunosuppressed organ-transplant recipients.
Transplantation 2005;79(4):451-9.
2005: An De Creus; Masanori Abe; Audrey H Lau; Holger Hackstein; Giorgio Raimondi; Angus W Thomson
Low TLR4 expression by liver dendritic cells correlates with reduced capacity to activate allogeneic T cells in response to endotoxin.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):2037-45.
2005: George V Mazariegos; Alan F Zahorchak; Jorge Reyes; Holly Chapman; Adriana Zeevi; Angus W Thomson
Dendritic cell subset ratio in tolerant, weaning and non-tolerant liver recipients is not affected by extent of immunosuppression.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(2):314-22.
2005: Timucin Taner; Holger Hackstein; Zhiliang Wang; Adrian E Morelli; Angus W Thomson
Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(2):228-36.
2005: Olga Azhipa; Kei Kimizuka; Atsunori Nakao; Hideyoshi Toyokawa; Toyokazu Okuda; Joao Seda Neto; Sean Alber; Takashi Kaizu; Angus W Thomson; Anthony J Demetris; Noriko Murase
Comparative analysis of the fate of donor dendritic cells and B cells and their influence on alloreactive T cell responses under tacrolimus immunosuppression.
Clinical immunology (Orlando, Fla.) 2005;114(2):199-209.
2005: Giorgio Raimondi; Angus W Thomson
Dendritic cells,tolerance and therapy of organ allograft rejection.
Contributions to nephrology 2005;146():105-20.
2004: Adrian E Morelli; Adriana T Larregina; William J Shufesky; Mara L G Sullivan; Donna B Stolz; Glenn D Papworth; Alan F Zahorchak; Alison J Logar; Zhiliang Wang; simon simon watkins; Louis Falo; Angus W Thomson
Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells.
Blood 2004;104(10):3257-66.
2004: Bridget L Colvin; Audrey H Lau; Amanda M Schell; Angus W Thomson
Disparate ability of murine CD8alpha- and CD8alpha+ dendritic cell subsets to traverse endothelium is not determined by differential CD11b expression.
Immunology 2004;113(3):328-37.
2004: P Toby H Coates; Bridget L Colvin; Anju Ranganathan; F Jason Duncan; Yuk Yuen Lan; William J Shufesky; Alan F Zahorchak; Adrian E Morelli; Angus W Thomson
CCR and CC chemokine expression in relation to Flt3 ligand-induced renal dendritic cell mobilization.
Kidney international 2004;66(5):1907-17.
2004: Masanore Abe; Alan F Zahorchak; Bridget L Colvin; Angus W Thomson
Migratory responses of murine hepatic myeloid, lymphoid-related, and plasmacytoid dendritic cells to CC chemokines.
Transplantation 2004;78(5):762-5.
2004: Zhiliang Wang; Antonino Castellaneta; An De Creus; William J Shufesky; Adrian E Morelli; Angus W Thomson
Heart, but not skin, allografts from donors lacking Flt3 ligand exhibit markedly prolonged survival time.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):5924-30.
2004: P Toby H Coates; F Jason Duncan; Bridget L Colvin; Zhiliang Wang; Alan F Zahorchak; William J Shufesky; Adrian E Morelli; Angus W Thomson
In vivo-mobilized kidney dendritic cells are functionally immature, subvert alloreactive T-cell responses, and prolong organ allograft survival.
Transplantation 2004;77(7):1080-9.
2004: Jukka Vakkila; Angus W Thomson; Kim Vettenranta; H Sariola; U M Saarinen-Pihkala
Dendritic cell subsets in childhood and in children with cancer: relation to age and disease prognosis.
Clinical and experimental immunology 2004;135(3):455-61.
2004: Timucin Taner; Angus W Thomson
Fashioning regulatory dendritic cells: what is currently in vogue?
Current opinion in molecular therapeutics 2004;6(1):78-82.
2004: Antonino Castellaneta; Masanori Abe; Adrian E Morelli; Angus W Thomson
Identification and characterization of intestinal Peyer's patch interferon-alpha producing (plasmacytoid) dendritic cells.
Human immunology 2004;65(2):104-13.
2004: Bridget L Colvin; Adrian E Morelli; Alison J Logar; Audrey H Lau; Angus W Thomson
Comparative evaluation of CC chemokine-induced migration of murine CD8alpha+ and CD8alpha- dendritic cells and their in vivo trafficking.
Journal of leukocyte biology 2004;75(2):275-85.
2004: Adriana T Larregina; Adrian E Morelli; Olga Tkacheva; Geza Erdos; Cara Donahue; simon simon watkins; Angus W Thomson; Louis Falo
Highly efficient expression of transgenic proteins by naked DNA-transfected dendritic cells through terminal differentiation.
Blood 2004;103(3):811-9.
2004: Holger Hackstein; Angus W Thomson
Dendritic cells: emerging pharmacological targets of immunosuppressive drugs.
Nature reviews. Immunology 2004;4(1):24-34.
2003: Adrian E Morelli; Angus W Thomson
Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction.
Immunological reviews 2003;196():125-46.
2003: P Toby H Coates; Simon M Barratt-Boyes; Linyou Zhang; Vera S Donnenberg; Peta J O'Connell; Alison J Logar; F Jason Duncan; Michael Murphey-Corb; Albert D Donnenberg; Adrian E Morelli; Charles R Maliszewski; Angus W Thomson
Dendritic cell subsets in blood and lymphoid tissue of rhesus monkeys and their mobilization with Flt3 ligand.
Blood 2003;102(7):2513-21.
2003: Katsuhiko Kaneko; Adrian E Morelli; Zhiliang Wang; Angus W Thomson
Alloantigen presentation by ethylcarbodiimide-treated dendritic cells induces T cell hyporesponsiveness, and prolongs organ graft survival.
Clinical immunology (Orlando, Fla.) 2003;108(3):190-8.
2003: Zhiliang Wang; Adrian E Morelli; Holger Hackstein; Katsuhiko Kaneko; Angus W Thomson
Marked inhibition of transplant vascular sclerosis by in vivo-mobilized donor dendritic cells and anti-CD154 mAb.
Transplantation 2003;76(3):562-71.
2003: Audrey H Lau; An De Creus; Lina Lu; Angus W Thomson
Liver tolerance mediated by antigen presenting cells: fact or fiction?
Gut 2003;52(8):1075-8.
2003: Christoph Steinschulte; Timucin Taner; Angus W Thomson; Gregor Bein; Holger Hackstein
Cutting edge: sanglifehrin A, a novel cyclophilin-binding immunosuppressant blocks bioactive IL-12 production by human dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):542-6.
2003: Masanori Abe; Angus W Thomson
Influence of immunosuppressive drugs on dendritic cells.
Transplant immunology 2003;11(3-4):357-65.
2003: Peta J O'Connell; Young-Ik Son; Adam Giermasz; Zhiliang Wang; Alison J Logar; Angus W Thomson; Pawel Kalinski
Type-1 polarized nature of mouse liver CD8alpha- and CD8alpha+ dendritic cells: tissue-dependent differences offset CD8alpha-related dendritic cell heterogeneity.
European journal of immunology 2003;33(7):2007-13.
2003: Penelope A Morel; Maryam Feili-Hariri; P Toby H Coates; Angus W Thomson
Dendritic cells, T cell tolerance and therapy of adverse immune reactions.
Clinical and experimental immunology 2003;133(1):1-10.
2003: George V Mazariegos; Alan F Zahorchak; Jorge Reyes; Lynn Ostrowski; Bridget Flynn; Adriana Zeevi; Angus W Thomson
Dendritic cell subset ratio in peripheral blood correlates with successful withdrawal of immunosuppression in liver transplant patients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(6):689-96.
2003: Holger Hackstein; Timucin Taner; Alan F Zahorchak; Adrian E Morelli; Alison J Logar; Andre Gessner; Angus W Thomson
Rapamycin inhibits IL-4--induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo.
Blood 2003;101(11):4457-63.
2003: P Toby H Coates; Bridget L Colvin; Katsuhiko Kaneko; Timucin Taner; Angus W Thomson
Pharmacologic, biologic, and genetic engineering approaches to potentiation of donor-derived dendritic cell tolerogenicity.
Transplantation 2003;75(9 Suppl):32S-36S.
2003: Adrian E Morelli; Angus W Thomson
Dendritic cells under the spell of prostaglandins.
Trends in immunology 2003;24(3):108-11.
2003: Audrey H Lau; Angus W Thomson
Dendritic cells and immune regulation in the liver.
Gut 2003;52(2):307-14.
2003: Adrian E Morelli; Adriana T Larregina; William J Shufesky; Alan F Zahorchak; Alison J Logar; Glenn D Papworth; Zhiliang Wang; simon simon watkins; Louis Falo; Angus W Thomson
Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production.
Blood 2003;101(2):611-20.
2003: Katsuhiko Kaneko; Zhiliang Wang; Seon Hee Kim; Adrian E Morelli; Paul D Robbins; Angus W Thomson
Dendritic cells genetically engineered to express IL-4 exhibit enhanced IL-12p70 production in response to CD40 ligation and accelerate organ allograft rejection.
Gene therapy 2003;10(2):143-52.
2002: Angus W Thomson
Designer dendritic cells for transplant tolerance.
Transplantation proceedings 2002;34(7):2727-8.
2002: P Toby H Coates; Simon M Barratt-Boyes; Albert D Donnenberg; Adrian E Morelli; Michael Murphey-Corb; Angus W Thomson
Strategies for preclinical evaluation of dendritic cell subsets for promotion of transplant tolerance in the nonhuman primate.
Human immunology 2002;63(10):955-65.
2002: Rosemary A Hoffman; Raja Mahidhara; Amanda Wolf-Johnston; Lina Lu; Angus W Thomson; Richard L Simmons
Differential modulation of CD4 and CD8 T-cell proliferation by induction of nitric oxide synthesis in antigen presenting cells.
Transplantation 2002;74(6):836-45.
2002: C Andrew Bonham; Lansha Peng; Xiaoyan Liang; Zongyou Chen; Lianfu Wang; Linlin Ma; Holger Hackstein; Paul D Robbins; Angus W Thomson; John J Fung; Shiguang Qian; Lina Lu
Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):3382-91.
2002: Robert I Lechler; Megan Sykes; Angus W Thomson; Laurence A Turka
Designer meetings.
Nature immunology 2002;3(9):791.
2002: Masatoshi Eto; Holger Hackstein; Katsuhiko Kaneko; Kikuo Nomoto; Angus W Thomson
Promotion of skin graft tolerance across MHC barriers by mobilization of dendritic cells in donor hemopoietic cell infusions.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(5):2390-6.
2002: Massimo Trucco; Paul D Robbins; Angus W Thomson; Nick Giannoukakis
Gene therapy strategies to prevent autoimmune disorders.
Current gene therapy 2002;2(3):341-54.
2002: Holger Hackstein; Zhiliang Wang; Adrian E Morelli; Katsuhiko Kaneko; Takuya Takayama; Bridget L Colvin; Gregor Bein; Angus W Thomson
Normal donor bone marrow is superior to Flt3 ligand-mobilized bone marrow in prolonging heart allograft survival when combined with anti-CD40L (CD154).
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2002;2(7):609-17.
2002: Susanne Beckebaum; Vito R Cicinnati; Grzegorz Dworacki; Jan Muller-Berghaus; Donna Stolz; Jo Harnaha; Theresa L Whiteside; Angus W Thomson; Lina Lu; John J Fung; C Andrew Bonham
Reduction in the circulating pDC1/pDC2 ratio and impaired function of ex vivo-generated DC1 in chronic hepatitis B infection.
Clinical immunology (Orlando, Fla.) 2002;104(2):138-50.
2002: Holger Hackstein; Timucin Taner; Alison J Logar; Angus W Thomson
Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells.
Blood 2002;100(3):1084-7.
2002: Bridget L Colvin; Angus W Thomson
Chemokines, their receptors, and transplant outcome.
Transplantation 2002;74(2):149-55.
2002: Takuya Takayama; Katsuhiko Kaneko; Adrian E Morelli; Wei Li; Hideaki Tahara; Angus W Thomson
Retroviral delivery of transforming growth factor-beta1 to myeloid dendritic cells: inhibition of T-cell priming ability and influence on allograft survival.
Transplantation 2002;74(1):112-9.
2002: George V Mazariegos; Jorge Reyes; Steven A Webber; Angus W Thomson; Lynn Ostrowski; Mamun Abmed; Gina Pillage; joan martell; Mohammed R Awad; Adriana Zeevi
Cytokine gene polymorphisms in children successfully withdrawn from immunosuppression after liver transplantation.
Transplantation 2002;73(8):1342-5.
2002: P Toby H Coates; Angus W Thomson
Dendritic cells, tolerance induction and transplant outcome.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2002;2(4):299-307.
2002: P Toby H Coates; Bridget L Colvin; Holger Hackstein; Angus W Thomson
Manipulation of dendritic cells as an approach to improved outcomes in transplantation.
Expert reviews in molecular medicine 2002;4(3):1-21.
2002: Angus W Thomson; Peta J O'Connell; Raymond J Steptoe; Lina Lu
Immunobiology of liver dendritic cells.
Immunology and cell biology 2002;80(1):65-73.
2002: Lina Lu; Angus W Thomson
Manipulation of dendritic cells for tolerance induction in transplantation and autoimmune disease.
Transplantation 2002;73(1 Suppl):S19-22.
2002: John J Fung; Angus W Thomson; Ron Shapiro
Highlights of the Festschrift in honor of Thomas E. Starzl, MD, PHD.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2002;2(1):7-11.
2002: Peta J O'Connell; Wei Li; Zhiliang Wang; Susan Specht; Alison J Logar; Angus W Thomson
Immature and mature CD8alpha+ dendritic cells prolong the survival of vascularized heart allografts.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):143-54.
2001: Vera S Donnenberg; Peta J O'Connell; Alison J Logar; Adriana Zeevi; Angus W Thomson; Albert D Donnenberg
Rare-event analysis of circulating human dendritic cell subsets and their presumptive mouse counterparts.
Transplantation 2001;72(12):1946-51.
2001: J D Whalen; Angus W Thomson; Lina Lu; Paul D Robbins; Christopher H Evans
Viral IL-10 gene transfer inhibits DTH responses to soluble antigens: evidence for involvement of genetically modified dendritic cells and macrophages.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(6):543-50.
2001: Adriana T Larregina; Adrian E Morelli; L A Spencer; Alison J Logar; simon simon watkins; Angus W Thomson; Louis Falo
Dermal-resident CD14+ cells differentiate into Langerhans cells.
Nature immunology 2001;2(12):1151-8.
2001: Angus W Thomson; George V Mazariegos; Jorge Reyes; Vera S Donnenberg; Albert D Donnenberg; C Bentlejewski; Alan F Zahorchak; Peta J O'Connell; John J Fung; Ewa Jankowska-Gan; William J Burlingham; P S Heeger; Adriana Zeevi
Monitoring the patient off immunosuppression. Conceptual framework for a proposed tolerance assay study in liver transplant recipients.
Transplantation 2001;72(8 Suppl):S13-22.
2001: Wei Li; Lina Lu; Zhiliang Wang; Lianfu Wang; John J Fung; Angus W Thomson; Shiguang Qian
Costimulation blockade promotes the apoptotic death of graft-infiltrating T cells and prolongs survival of hepatic allografts from FLT3L-treated donors.
Transplantation 2001;72(8):1423-32.
2001: Adrian E Morelli; Alan F Zahorchak; Adriana T Larregina; Bridget L Colvin; Alison J Logar; Takuya Takayama; Louis Falo; Angus W Thomson
Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation.
Blood 2001;98(5):1512-23.
2001: Holger Hackstein; Adrian E Morelli; Angus W Thomson
Designer dendritic cells for tolerance induction: guided not misguided missiles.
Trends in immunology 2001;22(8):437-42.
2001: J L Tang; Vladimir M Subbotin; MA Antonysamy; AB Troutt; Abdul S Rao; Angus W Thomson
Interleukin-17 antagonism inhibits acute but not chronic vascular rejection.
Transplantation 2001;72(2):348-50.
2001: Takuya Takayama; Adrian E Morelli; N Onai; M Hirao; K Matsushima; Hideaki Tahara; Angus W Thomson
Mammalian and viral IL-10 enhance C-C chemokine receptor 5 but down-regulate C-C chemokine receptor 7 expression by myeloid dendritic cells: impact on chemotactic responses and in vivo homing ability.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7136-43.
2001: Holger Hackstein; Adrian E Morelli; Adriana T Larregina; Raymond W Ganster; Glenn D Papworth; Alison J Logar; simon simon watkins; Louis Falo; Angus W Thomson
Aspirin inhibits in vitro maturation and in vivo immunostimulatory function of murine myeloid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7053-62.
2001: Takuya Takayama; Hideaki Tahara; Angus W Thomson
Differential effects of myeloid dendritic cells retrovirally transduced to express mammalian or viral interleukin-10 on cytotoxic T lymphocyte and natural killer cell functions and resistance to tumor growth.
Transplantation 2001;71(9):1334-40.
2001: Wei Li; Lina Lu; Zhiliang Wang; Lianfu Wang; John J Fung; Angus W Thomson; Shiguang Qian
Il-12 antagonism enhances apoptotic death of T cells within hepatic allografts from Flt3 ligand-treated donors and promotes graft acceptance.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5619-28.
2001: Stephen H Gregory; Asia Sagnimeni; N B Zurowski; Angus W Thomson
Flt3 ligand pretreatment promotes protective immunity to Listeria monocytogenes.
Cytokine 2001;13(4):202-8.
2001: Takuya Takayama; H Tahara; Angus W Thomson
Retrovirally transduced myeloid dendritic cells expressing mammalian or viral IL-10 differentially affect cell-mediated immunity and growth of transplantable tumors.
Transplantation proceedings 2001;33(1-2):590.
2001: Wei Li; Lina Lu; Lianfu Wang; Zhiliang Wang; Angus W Thomson; John J Fung; Shiguang Qian
Neutralization of IL-12 reverses rejection of mouse liver allografts from Flt3-ligand-treated donors and is associated with suppression of both cellular and humoral responses.
Transplantation proceedings 2001;33(1-2):525.
2001: Patrick P W Luke; Angus W Thomson
Blockade of costimulatory molecules on dendritic cells: implications for tolerance induction.
Transplantation proceedings 2001;33(1-2):507-8.
2001: Peta J O'Connell; Alison J Logar; Angus W Thomson
Differential regulation of T-cell proliferation and apoptosis by hepatic CD8alpha(+) (lymphoid-related) and CD8alpha(-) (myeloid) dendritic cells.
Transplantation proceedings 2001;33(1-2):250-1.
2001: Peta J O'Connell; Wei Li; Takuya Takayama; Alison J Logar; Shiguang Qian; Angus W Thomson
CD8alpha(+) (lymphoid-related) and CD8alpha(-) (myeloid) dendritic cells differentially regulate vascularized organ allograft survival.
Transplantation proceedings 2001;33(1-2):94.
2001: Lina Lu; ML Drakes; Angus W Thomson
Isolation and propagation of mouse liver-derived dendritic cells.
Methods in molecular medicine 2001;64():85-95.
2000: S Koga; Patrick P W Luke; Susan Specht; BR Rominski; A Jaquins-Gerstl; Rosemary A Hoffman; Angus W Thomson; Mark L Jordan
Inhibition of the allograft response by donor specific blood transfusion: association with reduced local TH1 cytokines and nitric oxide but enhanced prostaglandin E2 production.
Transplantation 2000;70(12):1788-96.
2000: A Hirano; Patrick P W Luke; Susan Specht; Matthew Fraser; Takuya Takayama; Lina Lu; R Hoffman; Angus W Thomson; Mark L Jordan
Graft hyporeactivity induced by immature donor-derived dendritic cells.
Transplant immunology 2000;8(3):161-8.
2000: Adrian E Morelli; Angus W Thomson
Role of dendritic cells in the immune response against allografts.
Current opinion in nephrology and hypertension 2000;9(6):607-13.
2000: W C Lee; S Qiani; Yonghong Wan; Wei Li; Zhou Xing; J Gauldie; John J Fung; Angus W Thomson; Lina Lu
Contrasting effects of myeloid dendritic cells transduced with an adenoviral vector encoding interleukin-10 on organ allograft and tumour rejection.
Immunology 2000;101(2):233-41.
2000: Adrian E Morelli; Adriana T Larregina; Raymond W Ganster; Alan F Zahorchak; Jeffrey Plowey; T Takayama; Alison J Logar; Paul D Robbins; Louis Falo; Angus W Thomson
Recombinant adenovirus induces maturation of dendritic cells via an NF-kappaB-dependent pathway.
Journal of virology 2000;74(20):9617-28.
2000: T Takayama; Adrian E Morelli; Paul D Robbins; Hideaki Tahara; Angus W Thomson
Feasibility of CTLA4Ig gene delivery and expression in vivo using retrovirally transduced myeloid dendritic cells that induce alloantigen-specific T cell anergy in vitro.
Gene therapy 2000;7(15):1265-73.
2000: Peta J O'Connell; Adrian E Morelli; Alison J Logar; Angus W Thomson
Phenotypic and functional characterization of mouse hepatic CD8 alpha+ lymphoid-related dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):795-803.
2000: Adrian E Morelli; MA Antonysamy; Takuya Takayama; Holger Hackstein; Zongyou Chen; Shiguang Qian; N B Zurowski; Angus W Thomson
Microchimerism, donor dendritic cells, and alloimmune reactivity in recipients of Flt3 ligand-mobilized hemopoietic cells: modulation by tacrolimus.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):226-37.
2000: Adrian E Morelli; Peta J O'Connell; A Khanna; Alison J Logar; Lina Lu; Angus W Thomson
Preferential induction of Th1 responses by functionally mature hepatic (CD8alpha- and CD8alpha+) dendritic cells: association with conversion from liver transplant tolerance to acute rejection.
Transplantation 2000;69(12):2647-57.
2000: Nick Giannoukakis; C Andrew Bonham; Shiguang Qian; Z Chen; L Peng; Jo Harnaha; W Li; Angus W Thomson; John J Fung; Paul D Robbins; Lina Lu; Z Zhou
Prolongation of cardiac allograft survival using dendritic cells treated with NF-kB decoy oligodeoxyribonucleotides.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(5 Pt 1):430-7.
2000: Raymond J Steptoe; R K Patel; Vladimir M Subbotin; Angus W Thomson
Comparative analysis of dendritic cell density and total number in commonly transplanted organs: morphometric estimation in normal mice.
Transplant immunology 2000;8(1):49-56.
2000: ML Drakes; Alan F Zahorchak; Takuya Takayama; Lina Lu; Angus W Thomson
Chemokine and chemokine receptor expression by liver-derived dendritic cells: MIP-1alpha production is induced by bacterial lipopolysaccharide and interaction with allogeneic T cells.
Transplant immunology 2000;8(1):17-29.
2000: MA Antonysamy; Angus W Thomson
Flt3 ligand (FL) and its influence on immune reactivity.
Cytokine 2000;12(2):87-100.
2000: A Khanna; Adrian E Morelli; C Zhong; Takuya Takayama; Lina Lu; Angus W Thomson
Effects of liver-derived dendritic cell progenitors on Th1- and Th2-like cytokine responses in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1346-54.
1999: Takuya Takayama; Hideaki Tahara; Angus W Thomson
Transduction of dendritic cell progenitors with a retroviral vector encoding viral interleukin-10 and enhanced green fluorescent protein allows purification of potentially tolerogenic antigen-presenting cells.
Transplantation 1999;68(12):1903-9.
1999: Wei Li; F Fu; Lina Lu; S K Narula; John J Fung; Angus W Thomson; Shiguang Qian
Differential effects of exogenous interleukin-10 on cardiac allograft survival: inhibition of rejection by recipient pretreatment reflects impaired host accessory cell function.
Transplantation 1999;68(9):1402-9.
1999: J I Lee; Raymond W Ganster; David A Geller; Gilbert J Burckart; Angus W Thomson; Lina Lu
Cyclosporine A inhibits the expression of costimulatory molecules on in vitro-generated dendritic cells: association with reduced nuclear translocation of nuclear factor kappa B.
Transplantation 1999;68(9):1255-63.
1999: Angus W Thomson; Takuya Takayama
Dendritic cells and the outcome of organ transplantation: a contemporary view.
Transplantation proceedings 1999;31(7):2738-9.
1999: Lina Lu; Wei Li; C Zhong; Shiguang Qian; John J Fung; Angus W Thomson; Thomas E Starzl
Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendritic cells plus anti-CD40L mAb.
Transplantation 1999;68(6):747-57.
1999: Angus W Thomson; ML Drakes; Alan F Zahorchak; Peta J O'Connell; Raymond J Steptoe; Shiguang Qian; Lina Lu
Hepatic dendritic cells: immunobiology and role in liver transplantation.
Journal of leukocyte biology 1999;66(2):322-30.
1999: Lina Lu; WC Lee; T Takayama; Shiguang Qian; Andrea Gambotto; Paul D Robbins; Angus W Thomson
Genetic engineering of dendritic cells to express immunosuppressive molecules (viral IL-10, TGF-beta, and CTLA4Ig).
Journal of leukocyte biology 1999;66(2):293-6.
1999: Angus W Thomson; Lina Lu
Dendritic cells as regulators of immune reactivity: implications for transplantation.
Transplantation 1999;68(1):1-8.
1999: Thomas E Starzl; Noriko Murase; Angus W Thomson; Massimo Trucco; A Rao
Regulation of immune reactivity and tolerance by antigen migration and localization: with particular reference to allo- and xenotransplantation.
Transplantation proceedings 1999;31(4):1806-11.
1999: Lina Lu; Andrea Gambotto; WC Lee; Shiguang Qian; C Andrew Bonham; Paul D Robbins; Angus W Thomson
Adenoviral delivery of CTLA4Ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients.
Gene therapy 1999;6(4):554-63.
1999: Raymond J Steptoe; Wei Li; F Fu; Peta J O'Connell; Angus W Thomson
Trafficking of APC from liver allografts of Flt3L-treated donors: augmentation of potent allostimulatory cells in recipient lymphoid tissue is associated with a switch from tolerance to rejection.
Transplant immunology 1999;7(1):51-7.
1999: F Fu; Wei Li; Lina Lu; Angus W Thomson; John J Fung; Shiguang Qian
Prevention and restoration of second-set liver allograft rejection in presensitized mice: the role of "passenger" leukocytes, donor major histocompatibility complex antigens, and host cytotoxic effector mechanisms.
Transplantation 1999;67(3):444-50.
1999: Thomas E Starzl; Noriko Murase; Angus W Thomson; Massimo Trucco; A Rao
Immunity and tolerance are related, and governed by antigen migration and localization.
Transplantation proceedings 1999;31(1-2):1406-11.
1999: F Fu; Wei Li; Lina Lu; Angus W Thomson; John J Fung; Shiguang Qian
Systemic administration of CTLA4-Ig or anti-CD40 ligand antibody inhibits second-set rejection of mouse liver allografts.
Transplantation proceedings 1999;31(1-2):1244.
1999: WC Lee; Yonghong Wan; Wei Li; F Fu; P J Sime; J Gauldie; Angus W Thomson; John J Fung; Lina Lu; Shiguang Qian
Enhancement of dendritic cell tolerogenicity by genetic modification using adenoviral vectors encoding cDNA for TGF beta 1.
Transplantation proceedings 1999;31(1-2):1195.
1999: Lina Lu; WC Lee; Andrea Gambotto; C Zhong; Paul D Robbins; Shiguang Qian; John J Fung; Angus W Thomson
Transduction of dendritic cells with adenoviral vectors encoding CTLA4-Ig markedly reduces their allostimulatory activity.
Transplantation proceedings 1999;31(1-2):797.
1999: Y C Lee; Lina Lu; F Fu; Wei Li; Angus W Thomson; John J Fung; Shiguang Qian
Hepatocytes and liver nonparenchymal cells induce apoptosis in activated T cells.
Transplantation proceedings 1999;31(1-2):784.
1999: Thomas E Starzl; Noriko Murase; Angus W Thomson; Massimo Trucco; A Rao
Regulation of immune reactivity and tolerance by antigen migration and localization: with particular reference to allo- and xenotransplantation.
Transplantation proceedings 1999;31(1-2):763-8.
1999: F Fu; W Li; L Lu; John J Fung; Angus W Thomson; S Qian
Treatment with CTLA4-Ig inhibits rejection of liver allografts from FIt3-ligand-treated donors.
Transplantation proceedings 1999;31(1-2):453.
1999: Wei Li; F Fu; Lina Lu; S K Narula; John J Fung; Angus W Thomson; Shiguang Qian
Recipient pretreatment with mammalian IL-10 prolongs mouse cardiac allograft survival by inhibition of anti-donor T cell responses.
Transplantation proceedings 1999;31(1-2):115.
1999: MA Antonysamy; W C Fanslow; F Fu; Wei Li; Shiguang Qian; AB Troutt; Angus W Thomson
Evidence for a role of IL-17 in alloimmunity: a novel IL-17 antagonist promotes heart graft survival.
Transplantation proceedings 1999;31(1-2):93.
1999: Angus W Thomson; L Lu
Are dendritic cells the key to liver transplant tolerance?
Immunology today 1999;20(1):27-32.
1999: MA Antonysamy; W C Fanslow; F Fu; Wei Li; Shiguang Qian; AB Troutt; Angus W Thomson
Evidence for a role of IL-17 in organ allograft rejection: IL-17 promotes the functional differentiation of dendritic cell progenitors.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):577-84.
1998: W C Lee; C Zhong; Shiguang Qian; Yonghong Wan; J Gauldie; Z Mi; Paul D Robbins; Angus W Thomson; Lina Lu
Phenotype, function, and in vivo migration and survival of allogeneic dendritic cell progenitors genetically engineered to express TGF-beta.
Transplantation 1998;66(12):1810-7.
1998: Wei Li; F Fu; Lina Lu; S K Narula; John J Fung; Angus W Thomson; Shiguang Qian
Systemic administration of anti-interleukin-10 antibody prolongs organ allograft survival in normal and presensitized recipients.
Transplantation 1998;66(12):1587-96.
1998: Takuya Takayama; Y Nishioka; Lina Lu; M T Lotze; Hideaki Tahara; Angus W Thomson
Retroviral delivery of viral interleukin-10 into myeloid dendritic cells markedly inhibits their allostimulatory activity and promotes the induction of T-cell hyporesponsiveness.
Transplantation 1998;66(12):1567-74.
1998: A Khanna; MA Antonysamy; Vladimir M Subbotin; Raymond J Steptoe; Wei Li; William A Rudert; Angus W Thomson
Impact of Flt-3 ligand on donor-derived antigen presenting cells and alloimmune reactivity in heart graft recipients given adjuvant donor bone marrow.
Transplant immunology 1998;6(4):225-34.
1998: S G Shaw; A A Maung; Raymond J Steptoe; Angus W Thomson; Nikola L Vujanovic
Expansion of functional NK cells in multiple tissue compartments of mice treated with Flt3-ligand: implications for anti-cancer and anti-viral therapy.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):2817-24.
1998: M Terakura; Noriko Murase; Anthony J Demetris; Q Ye; Angus W Thomson; Thomas E Starzl
Lymphoid/nonlymphoid compartmentalization of donor leukocyte chimerism in rat recipients of heart allografts, with or without adjunct bone marrow.
Transplantation 1998;66(3):350-7.
1998: Shiguang Qian; Lina Lu; F Fu; Wei Li; F Pan; Raymond J Steptoe; FG Chambers; Thomas E Starzl; John J Fung; Angus W Thomson
Donor pretreatment with Flt-3 ligand augments antidonor cytotoxic T lymphocyte, natural killer, and lymphokine-activated killer cell activities within liver allografts and alters the pattern of intragraft apoptotic activity.
Transplantation 1998;65(12):1590-8.
1998: David A Gerber; C Andrew Bonham; Angus W Thomson
Immunosuppressive agents: recent developments in molecular action and clinical application.
Transplantation proceedings 1998;30(4):1573-9.
1998: MA Antonysamy; Raymond J Steptoe; A Khanna; William A Rudert; Vladimir M Subbotin; Angus W Thomson
Flt-3 ligand increases microchimerism but can prevent the therapeutic effect of donor bone marrow in transiently immunosuppressed cardiac allograft recipients.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(8):4106-13.
1998: A Khanna; Raymond J Steptoe; MA Antonysamy; Wei Li; Angus W Thomson
Donor bone marrow potentiates the effect of tacrolimus on nonvascularized heart allograft survival: association with microchimerism and growth of donor dendritic cell progenitors from recipient bone marrow.
Transplantation 1998;65(4):479-85.
1997: Lina Lu; Wei Li; F Fu; FG Chambers; Shiguang Qian; John J Fung; Angus W Thomson
Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival.
Transplantation 1997;64(12):1808-15.
1997: Raymond J Steptoe; F Fu; Wei Li; ML Drakes; Lina Lu; Anthony Demetris; Shiguang Qian; H J McKenna; Angus W Thomson
Augmentation of dendritic cells in murine organ donors by Flt3 ligand alters the balance between transplant tolerance and immunity.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5483-91.
1997: ML Drakes; Lina Lu; Vladimir M Subbotin; Angus W Thomson
In vivo administration of flt3 ligand markedly stimulates generation of dendritic cell progenitors from mouse liver.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4268-78.
1997: Noriko Murase; Q Ye; T Sakamoto; M Terakura; Anthony J Demetris; Angus W Thomson; A Rao; Thomas E Starzl
Effect in supralethally irradiated rats of granulocyte colony-stimulating factor and lisofylline on hematopoietic reconstitution by syngeneic bone marrow or whole organ passenger leukocytes.
Transplantation 1997;63(12):1840-3.
1997: Lina Lu; Shiguang Qian; Pamela A Hershberger; William A Rudert; DH Lynch; Angus W Thomson
Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5676-84.
1997: AR Iyengar; C Andrew Bonham; MA Antonysamy; Vladimir M Subbotin; A Khanna; Noriko Murase; Abdul S Rao; Thomas E Starzl; Angus W Thomson
Striking augmentation of hematopoietic cell chimerism in noncytoablated allogeneic bone marrow recipients by FLT3 ligand and tacrolimus.
Transplantation 1997;63(9):1193-9.
1997: Shiguang Qian; Lina Lu; F Fu; Yuehua Li; Wei Li; Thomas E Starzl; John J Fung; Angus W Thomson
Apoptosis within spontaneously accepted mouse liver allografts: evidence for deletion of cytotoxic T cells and implications for tolerance induction.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4654-61.
1997: Thomas E Starzl; Anthony J Demetris; N Murase; Massimo Trucco; Angus W Thomson; Abdul S Rao; John J Fung
Chimerism after organ transplantation.
Current opinion in nephrology and hypertension 1997;6(3):292-8.
1997: F Fu; Y Li; Shiguang Qian; Lina Lu; F D Chambers; Thomas E Starzl; John J Fung; Angus W Thomson
Costimulatory molecule-deficient dendritic cell progenitors induce T cell hyporesponsiveness in vitro and prolong the survival of vascularized cardiac allografts.
Transplantation proceedings 1997;29(1-2):1310.
1997: Shiguang Qian; Lina Lu; Y Li; F Fu; Wei Li; Thomas E Starzl; Angus W Thomson; John J Fung
Apoptosis of graft-infiltrating cytotoxic T cells: a mechanism underlying "split tolerance" in mouse liver transplantation.
Transplantation proceedings 1997;29(1-2):1168-9.
1997: C Andrew Bonham; Lina Lu; Rosemary A Hoffman; Richard L Simmons; Angus W Thomson
Nitric oxide production by dendritic cells is associated with impairment of T cell responses.
Transplantation proceedings 1997;29(1-2):1116-7.
1997: Lina Lu; Shiguang Qian; Pamela A Hershberger; William A Rudert; Y Li; FG Chambers; Thomas E Starzl; DH Lynch; Angus W Thomson
Blocking of the B7-CD28 pathway increases apoptosis induced in activated T cells by in vitro-generated CD95L (FasL) positive dendritic cells.
Transplantation proceedings 1997;29(1-2):1094-5.
1997: Wei Li; Lina Lu; Y Li; F Fu; John J Fung; Angus W Thomson; Shiguang Qian
High-dose cellular IL-10 exacerbates rejection and reverses effects of cyclosporine and tacrolimus in Mouse cardiac transplantation.
Transplantation proceedings 1997;29(1-2):1081-2.
1997: Thomas E Starzl; Anthony J Demetris; Noriko Murase; Luis A Valdivia; Angus W Thomson; John Fung; Abdul S Rao
The future of transplantation: with particular reference to chimerism and xenotransplantation.
Transplantation proceedings 1997;29(1-2):19-27.
1997: C Andrew Bonham; Lina Lu; Rosemary A Hoffman; Richard L Simmons; Angus W Thomson
Generation of nitric oxide by mouse dendritic cells and its implications for immune response regulation.
Advances in experimental medicine and biology 1997;417():283-90.
1997: Lina Lu; Shiguang Qian; Thomas E Starzl; DH Lynch; Angus W Thomson
Blocking of the B7-CD28 pathway increases the capacity of FasL+ (CD95L+) dendritic cells to kill alloactivated T cells.
Advances in experimental medicine and biology 1997;417():275-82.
1997: ML Drakes; Lina Lu; H J McKenna; Angus W Thomson
The influence of collagen, fibronectin, and laminin on the maturation of dendritic cell progenitors propagated from normal or Flt3-ligand-treated mouse liver.
Advances in experimental medicine and biology 1997;417():115-20.
1996: C Andrew Bonham; Lina Lu; Y Li; Rosemary A Hoffman; Richard L Simmons; Angus W Thomson
Nitric oxide production by mouse bone marrow-derived dendritic cells: implications for the regulation of allogeneic T cell responses.
Transplantation 1996;62(12):1871-7.
1996: Shiguang Qian; Wei Li; Y Li; F Fu; Lina Lu; John J Fung; Angus W Thomson
Systemic administration of cellular interleukin-10 can exacerbate cardiac allograft rejection in mice.
Transplantation 1996;62(12):1709-14.
1996: Lina Lu; C Andrew Bonham; F G Chambers; simon simon watkins; Rosemary A Hoffman; Richard L Simmons; Angus W Thomson
Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with allogeneic T cells: nitric oxide production is associated with dendritic cell apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3577-86.
1996: F Fu; Y Li; Shiguang Qian; Lina Lu; F Chambers; Thomas E Starzl; John J Fung; Angus W Thomson
Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients.
Transplantation 1996;62(5):659-65.
1996: C Andrew Bonham; Lina Lu; R A Banas; Paulo Fontes; Abdul S Rao; Thomas E Starzl; Adriana Zeevi; Angus W Thomson
TGF-beta 1 pretreatment impairs the allostimulatory function of human bone marrow-derived antigen-presenting cells for both naive and primed T cells.
Transplant immunology 1996;4(3):186-91.
1996: Raymond J Steptoe; Angus W Thomson
Dendritic cells and tolerance induction.
Clinical and experimental immunology 1996;105(3):397-402.
1996: Shiguang Qian; F Fu; Y Li; Lina Lu; Abdul S Rao; Thomas E Starzl; Angus W Thomson; John J Fung
Impact of donor MHC class I or class II antigen deficiency on first- and second-set rejection of mouse heart or liver allografts.
Immunology 1996;88(1):124-9.
1996: F Fu; N L Thai; Y Li; Lina Lu; Angus W Thomson; John J Fung; Shiguang Qian
Second-set rejection of mouse liver allografts is dependent on radiation-sensitive nonparenchymal cells of graft bone marrow origin.
Transplantation 1996;61(8):1228-33.
1996: Noriko Murase; Thomas E Starzl; Q Ye; Athanassios C Tsamandas; Angus W Thomson; Abdul S Rao; Anthony J Demetris
Multilineage hematopoietic reconstitution of supralethally irradiated rats by syngeneic whole organ transplantation. With oarticular reference to the liver.
Transplantation 1996;61(1):1-4.
1995: Angus W Thomson; Lina Lu; Y Wan; Shiguang Qian; Christian P Larsen; Thomas E Starzl
Identification of donor-derived dendritic cell progenitors in bone marrow of spontaneously tolerant liver allograft recipients.
Transplantation 1995;60(12):1555-9.
1995: Lina Lu; D McCaslin; Thomas E Starzl; Angus W Thomson
Bone marrow-derived dendritic cell progenitors (NLDC 145+, MHC class II+, B7-1dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes.
Transplantation 1995;60(12):1539-45.
1995: Cristiana Rastellini; Lina Lu; Camillo Ricordi; Thomas E Starzl; Abdul S Rao; Angus W Thomson
Granulocyte/macrophage colony-stimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival.
Transplantation 1995;60(11):1366-70.
1995: Angus W Thomson; C Andrew Bonham; Adriana Zeevi
Mode of action of tacrolimus (FK506): molecular and cellular mechanisms.
Therapeutic drug monitoring 1995;17(6):584-91.
1995: Angus W Thomson; Lina Lu; Noriko Murase; Anthony J Demetris; Abdul S Rao; Thomas E Starzl
Microchimerism, dendritic cell progenitors and transplantation tolerance.
Stem cells (Dayton, Ohio) 1995;13(6):622-39.
1995: Thomas E Starzl; Anthony J Demetris; Noriko Murase; Massimo Trucco; Angus W Thomson; Abdul S Rao
The changing immunology of organ transplantation.
Hospital practice (1995) 1995;30(10):31-4, 37-42.
1995: S Satoh; Angus W Thomson; K Nakamura; VS Warty; Satoru Todo
Circulating ICAM-1, E-selectin, IL-2 receptor, and HLA class I in human small bowel, liver, and small bowel-plus-liver transplant recipients.
Transplantation 1995;60(6):558-62.
1995: Lina Lu; William A Rudert; Shiguang Qian; D McCaslin; F Fu; Abdul S Rao; Massimo Trucco; John J Fung; Thomas E Starzl; Angus W Thomson
Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor.
The Journal of experimental medicine 1995;182(2):379-87.
1995: H L Rodriguez Rilo; V M Subbotin; R R Selby; Angus W Thomson
Rapid hair regrowth in refractory alopecia universalis associated with autoimmune disease following liver transplantation and tacrolimus (FK506) therapy.
Transplantation 1995;59(9):1350-3.
1995: Shiguang Qian; F Fu; Y Li; L Gao; Lina Lu; H Noyola; Abdul S Rao; Angus W Thomson; John J Fung
Presensitization by skin grafting from major histocompatibility complex class I or major histocompatibility complex class II deficient mice identifies class I antigens as inducers of allosensitization.
Immunology 1995;85(1):82-7.
1995: J Woo; T M Wright; Bonnie Lemster; D Borochovitz; M A Nalesnik; Angus W Thomson
Combined effects of FK506 (tacrolimus) and cyclophosphamide on atypical B220+ T cells, cytokine gene expression and disease activity in MRL/MpJ-lpr/lpr mice.
Clinical and experimental immunology 1995;100(1):118-25.
1995: J Woo; Angus W Thomson; Suzanne Ildstad
Effects of FK 506 on chimerism and the induction of donor-specific unresponsiveness following fully allogeneic bone marrow transplantation in mice.
Transplant immunology 1995;3(1):86-90.
1995: Angus W Thomson; Lina Lu; V M Subbotin; Y Li; Shiguang Qian; Abdul S Rao; John J Fung; Thomas E Starzl
In vitro propagation and homing of liver-derived dendritic cell progenitors to lymphoid tissues of allogeneic recipients. Implications for the establishment and maintenance of donor cell chimerism following liver transplantation.
Transplantation 1995;59(4):544-51.
1995: J Woo; Lina Lu; F Fu; John J Fung; Shiguang Qian; Angus W Thomson
Suppression of alloreactive T-cell activation by murine liver F4/80+ accessory cells and kinetics of intrahepatic F4/80+ cells following liver transplantation.
Transplantation proceedings 1995;27(1):520-1.
1995: Shiguang Qian; F Fu; Y Li; L Gao; Lina Lu; H Noyola; Abdul S Rao; Angus W Thomson; Anthony J Demetris; Thomas E Starzl
The use of MHC class I or class II "knock out" mice to investigate the role of these antigens in allosensitization.
Transplantation proceedings 1995;27(1):475-6.
1995: Bonnie Lemster; P B Carroll; H R Rilo; N Johnson; A Nikaein; Angus W Thomson
IL-8/IL-8 receptor expression in psoriasis and the response to systemic tacrolimus (FK506) therapy.
Clinical and experimental immunology 1995;99(2):148-54.
1995: N L Thai; F Fu; Shiguang Qian; Hong Sun; L Gao; Stewart C Wang; Anthony J Demetris; J Woo; Angus W Thomson; Rene J Duquesnoy
Cytokine mRNA profiles in mouse orthotopic liver transplantation. Graft rejection is associated with augmented TH1 function.
Transplantation 1995;59(2):274-81.
1995: M Chen-Woan; C P Delaney; V Fournier; Y Wakizaka; Noriko Murase; Angus W Thomson; John J Fung; Thomas E Starzl; Anthony J Demetris
A simplified method for growing dendritic cells from rat bone marrow.
Advances in experimental medicine and biology 1995;378():53-5.
1995: Lina Lu; Michael Hsieh; Timothy B Oriss; Penelope A Morel; Thomas E Starzl; Abdul S Rao; Angus W Thomson
Generation of DC from mouse spleen cell cultures in response to GM-CSF: immunophenotypic and functional analyses.
Immunology 1995;84(1):127-34.
1995: Angus W Thomson; C Andrew Bonham
Inhibition of T lymphocyte activation and apoptotic cell death by cyclosporin A and tacrolimus (FK506). Its relevance to therapy of HIV infection.
Advances in experimental medicine and biology 1995;374():211-6.
1994: Angus W Thomson; Lina Lu; V Subbotin; Y Li; H Noyola; Shiguang Qian; Abdul S Rao; Anthony J Demetris; Thomas E Starzl
Propagation of dendritic cell progenitors from mouse liver and their in vivo migration to T-dependent areas of allogeneic lymphoid tissue.
Transplantation proceedings 1994;26(6):3484-6.
1994: Angus W Thomson; J V Forrester
Therapeutic advances in immunosuppression.
Clinical and experimental immunology 1994;98(3):351-7.
1994: Abdul S Rao; Angus W Thomson; Ron Shapiro; Thomas E Starzl
Chimerism after whole organ transplantation: its relationship to graft rejection and tolerance induction.
Current opinion in nephrology and hypertension 1994;3(6):589-95.
1994: Thomas E Starzl; Anthony J Demetris; Abdul S Rao; Angus W Thomson; Massimo Trucco; N Murase; Adriana Zeevi; Paulo Fontes
Spontaneous and iatrogenically augmented leukocyte chimerism in organ transplant recipients.
Transplantation proceedings 1994;26(5):3071-6.
1994: J Woo; Lina Lu; Abdul S Rao; Y Li; V Subbotin; Thomas E Starzl; Angus W Thomson
Isolation, phenotype, and allostimulatory activity of mouse liver dendritic cells.
Transplantation 1994;58(4):484-91.
1994: S Satoh; A K Nüssler; Z Z Liu; Angus W Thomson
Proinflammatory cytokines and endotoxin stimulate ICAM-1 gene expression and secretion by normal human hepatocytes.
Immunology 1994;82(4):571-6.
1994: Lina Lu; J Woo; Abdul S Rao; Y Li; simon simon watkins; Shiguang Qian; Thomas E Starzl; Anthony J Demetris; Angus W Thomson
Propagation of dendritic cell progenitors from normal mouse liver using granulocyte/macrophage colony-stimulating factor and their maturational development in the presence of type-1 collagen.
The Journal of experimental medicine 1994;179(6):1823-34.
1994: Angus W Thomson
The expanding repertoire of therapeutic antirejection molecules.
Transplant immunology 1994;2(2):144-8.
1994: S Satoh; Angus W Thomson; K Nakamura; VS Warty; Satoru Todo
Circulating adhesion molecules and other soluble markers of immune activation in human small bowel and small bowel plus liver transplantation.
Transplantation proceedings 1994;26(3):1417-8.
1994: C P Delaney; Angus W Thomson; Anthony J Demetris; Thomas E Starzl
Xenobiotics, chimerism and the induction of tolerance following organ transplantation.
Therapeutic immunology 1994;1(3):153-64.
1994: Angus W Thomson; S Satoh; A K Nüssler; K Tamura; J Woo; J Gavaler; David H Van Thiel
Circulating intercellular adhesion molecule-1 (ICAM-1) in autoimmune liver disease and evidence for the production of ICAM-1 by cytokine-stimulated human hepatocytes.
Clinical and experimental immunology 1994;95(1):83-90.
1994: J Woo; Suzanne Ildstad; Angus W Thomson
FK506 inhibits the differentiation of developing thymocytes but not negative selection of T cell receptor V beta 5+ and V beta 11+ T lymphocytes in vivo.
Transplant immunology 1994;2(1):11-21.
1994: H L Rilo; P B Carroll; V Subbotin; N Johnson; D H Van Thiel; Angus W Thomson
E-selectin and interleukin-2 receptor alpha-chain expression in alopecia universalis.
Acta dermato-venereologica 1994;74(1):33-6.
1993: J Woo; Luis A Valdivia; F Pan; S Celli; John J Fung; Angus W Thomson
Cytidine potentiates the inhibitory effect of brequinar sodium on xeno-MLR, antibody production, and concordant hamster to rat cardiac xenograft survival.
Annals of the New York Academy of Sciences 1993;696():227-34.
1993: K Tamura; J Woo; Noriko Murase; Michael A Nalesnik; Angus W Thomson
Inhibitory effect of FK 506 on autoimmune thyroid disease in the PVG rat.
Annals of the New York Academy of Sciences 1993;696():257-62.
1993: Bonnie Lemster; H R Rilo; P B Carroll; M A Nalesnik; Angus W Thomson
FK 506 inhibits cytokine gene and adhesion molecule expression in psoriatic skin lesions.
Annals of the New York Academy of Sciences 1993;696():250-6.
1993: Angus W Thomson; J Woo; Bonnie Lemster; W Irish; L L Huang; P B Carroll; H R Rilo; Kareem Abu-Elmagd; B Eidelman
Incidence of CD4+ IL-2R alpha+ and CD4+ CD45RA+ T-cells in progressive multiple sclerosis and the influence of short-term (3 months) FK 506 therapy.
Annals of the New York Academy of Sciences 1993;696():245-9.
1993: Bonnie Lemster; J Woo; Angus W Thomson
Blood lymphocytes of autoimmune disease patients receiving FK506 exhibit normal ex vivo cytokine gene expression and proliferative responses.
Immunology letters 1993;38(3):179-83.
1993: K Tamura; J Woo; M T Bakri; Angus W Thomson
Brequinar sodium inhibits interleukin-6-induced differentiation of a human B-cell line into IgM-secreting plasma cells.
Immunology 1993;79(4):587-93.
1993: J Woo; Bonnie Lemster; K Tamura; Thomas E Starzl; Angus W Thomson
The antilymphocytic activity of brequinar sodium and its potentiation by cytidine. Effects on lymphocyte proliferation and cytokine production.
Transplantation 1993;56(2):374-81.
1993: Thomas E Starzl; Anthony J Demetris; Noriko Murase; Angus W Thomson; Massimo Trucco; Camillo Ricordi
Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation.
Trends in pharmacological sciences 1993;14(5):217-23.
1993: K Tamura; J Woo; Noriko Murase; G Carrieri; M A Nalesnik; Angus W Thomson
Suppression of autoimmune thyroid disease by FK 506: influence on thyroid-infiltrating cells, adhesion molecule expression and anti-thyroglobulin antibody production.
Clinical and experimental immunology 1993;91(3):368-75.
1993: Angus W Thomson; J Woo; Bonnie Lemster; Satoru Todo; John J Fung; Thomas E Starzl
Potentiation of the antiproliferative activity of brequinar sodium for murine lymphocytes by exogenous cytidine.
Transplantation proceedings 1993;25(1 Pt 1):704-5.
1993: Angus W Thomson; J Woo; G Z Yao; Satoru Todo; Thomas E Starzl; Adriana Zeevi
Effects of combined administration of FK 506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T cell activation molecule expression in human mixed lymphocyte cultures.
Transplant immunology 1993;1(2):146-50.
1992: John J Fung; Angus W Thomson; AD Pinna; R R Selby; Thomas E Starzl
State of immunosuppressive agents in organ transplantation.
Transplantation proceedings 1992;24(6):2372-4.
1992: J Woo; Suzanne Ildstad; Angus W Thomson
FK 506 treatment following syngeneic bone marrow transplantation does not inhibit clonal deletion of V beta 5+ or V beta 11+ T cells.
Transplantation proceedings 1992;24(6):3031.
1992: Bonnie Lemster; J Woo; J Strednak; Stewart C Wang; Satoru Todo; Thomas E Starzl; Angus W Thomson
Cytokine gene expression in murine lymphocytes activated in the presence of FK 506, bredinin, mycophenolic acid, or brequinar sodium.
Transplantation proceedings 1992;24(6):2845-6.
1992: Angus W Thomson
The effects of cyclosporin A on non-T cell components of the immune system.
Journal of autoimmunity 1992;5 Suppl A():167-76.
1992: A K Nüssler; Angus W Thomson
Immunomodulatory agents in the laboratory and clinic.
Parasitology 1992;105 Suppl():S5-23.
1991: G Carrieri; Noriko Murase; J Woo; Michael A Nalesnik; A Azzarone; Y Funakoshi; Angus W Thomson; Satoru Todo; Thomas E Starzl
Effect of FK 506 in the prophylaxis of autoimmune glomerulonephritis in NZB/WF1 mice.
Transplantation proceedings 1991;23(6):3357-9.
1991: Angus W Thomson; Michael A Nalesnik; Kareem Abu-Elmagd; Thomas E Starzl
Influence of FK 506 on T lymphocytes, Langerhans' cells and the expression of cytokine receptors and adhesion molecules in psoriatic skin lesions: a preliminary study.
Transplantation proceedings 1991;23(6):3330-1.
1991: Kareem Abu-Elmagd; B V Jegasothy; C D Ackerman; Angus W Thomson; H Rilo; N Nikolaidis; David H Van Thiel; John J Fung; Satoru Todo; Thomas E Starzl
Efficacy of FK 506 in the treatment of recalcitrant pyoderma gangrenosum.
Transplantation proceedings 1991;23(6):3328-9.
1991: N L Nikolaidis; Kareem Abu-Elmagd; Angus W Thomson; H R Rilo; WD Irish; David H Van Thiel; John J Fung; Thomas E Starzl
Metabolic effects of FK 506 in patients with severe psoriasis: short-term follow-up of seven cases.
Transplantation proceedings 1991;23(6):3325-7.
1991: Kareem Abu-Elmagd; David H Van Thiel; B V Jegasothy; C D Ackerman; Satoru Todo; John J Fung; Angus W Thomson; Thomas E Starzl
FK 506: a new therapeutic agent for severe recalcitrant psoriasis.
Transplantation proceedings 1991;23(6):3322-4.
1991: M H Cooper; Stephen H Gregory; Angus W Thomson; John J Fung; Thomas E Starzl; Edward J Wing
Evaluation of the influence of FK 506, rapamycin, and cyclosporine on processing and presentation of particulate antigen by macrophages: assessment of a drug "carry-over" effect.
Transplantation proceedings 1991;23(6):2957-8.
1991: J Woo; Adriana Zeevi; G Z Yao; J Strednak; Satoru Todo; Angus W Thomson
Effects of FK 506, mycophenolic acid, and bredinin on OKT-3-, PMA-, and alloantigen-induced activation molecule expression on cultured CD4+ and CD8+ human lymphocytes.
Transplantation proceedings 1991;23(6):2939-40.
1991: J Woo; Suzanne Ildstad; M L Hronakes; Angus W Thomson
Kinetics of early T-cell repopulation in the mouse following syngeneic bone marrow transplantation: FK 506 causes a maturational defect of CD4+ CD8- T cells.
Transplantation proceedings 1991;23(6):2923-4.