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Snorri Thorgeirsson

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Denise Clavijo-Cornejo; Marcela Domínguez-Meraz; Mayra Domínguez-Pérez; Cristina Enriquez-Cortina; Valentina M Factor; Ma Concepción Gutiérrez-Ruiz; Alberto López-Reyes; Natalia Nuño; Verónica Souza; Snorri S Thorgeirsson; Maria del Carmen Escobar-Villanueva; Luis Enrique Gómez-Quiroz
Biphasic regulation of the NADPH oxidase by HGF/c-Met signaling pathway in primary mouse hepatocytes.
Jesper B andersen; Snorri S Thorgeirsson
Genomic decoding of intrahepatic cholangiocarcinoma reveals therapeutic opportunities.
Kshama R Jaiswal; Bo Kim; Tomotake Koizumi; Tyler Miller; Satyajit Ray; Udo Rudloff; Snorri S Thorgeirsson; Gordon Wiegand; Hong-Wu Xin; Andrew Anderson; Danielle Hari; Itzhak Avital
Comparative testing of various pancreatic cancer stem cells results in a novel class of pancreatic-cancer-initiating cells.

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2013: Denise Clavijo-Cornejo; Marcela Domínguez-Meraz; Mayra Domínguez-Pérez; Cristina Enriquez-Cortina; Valentina M Factor; Ma Concepción Gutiérrez-Ruiz; Alberto López-Reyes; Natalia Nuño; Verónica Souza; Snorri S Thorgeirsson; Maria del Carmen Escobar-Villanueva; Luis Enrique Gómez-Quiroz
Biphasic regulation of the NADPH oxidase by HGF/c-Met signaling pathway in primary mouse hepatocytes.
Biochimie 2013;95(6):1177-84.
2013: Jesper B andersen; Snorri S Thorgeirsson
Genomic decoding of intrahepatic cholangiocarcinoma reveals therapeutic opportunities.
Gastroenterology 2013;144(4):687-90.
2012: Kshama R Jaiswal; Bo Kim; Tomotake Koizumi; Tyler Miller; Satyajit Ray; Udo Rudloff; Snorri S Thorgeirsson; Gordon Wiegand; Hong-Wu Xin; Andrew Anderson; Danielle Hari; Itzhak Avital
Comparative testing of various pancreatic cancer stem cells results in a novel class of pancreatic-cancer-initiating cells.
Stem cell research 2012;9(3):249-60.
2012: Naoki Oishi; Lun-Xiu Qin; Stephanie Roessler; Zhao-You Tang; Snorri S Thorgeirsson; hyun goo woo; Taro Yamashita; Qing-Hai Ye; Xuelian Zhao; Jesper B andersen; Anuradha Budhu; Marshonna Forgues; Junfang Ji; Hu-Liang Jia; Shuichi Kaneko; Yoon Jun Kim; Mia R Kumar; Xin Wei Wang
Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma.
Hepatology (Baltimore, Md.) 2012;56(5):1792-803.
2012: Hala Elnakat Thomas; Snorri S Thorgeirsson; Jesper B Andersen; Bruce J Aronow; Larissa Carnevalli; Elizabeth A Conner; Akio Iwanami; S Michel Maira; Liu Manway; Tomoo Matsutani; Carol A Mercer; Paul S Mischel; Jongsun Park; Kazuhiro Tanaka; George Thomas; Sara C Kozma
mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma.
Science translational medicine 2012;4(139):139ra84.
2012: Jens U Marquardt; Daekwan Seo; Koichi Uchida; Elizabeth A Conner; Valentina M Factor; Matthew C Gillen; Luis E Gómez-Quiroz; Pal Kaposi-Novak; Mitsuteru Kitade; Snorri S Thorgeirsson
Loss of c-Met accelerates development of liver fibrosis in response to CCl(4) exposure through deregulation of multiple molecular pathways.
Biochimica et biophysica acta 2012;1822(6):942-51.
2012: Cédric Coulouarn; Denise Glaise; Isabelle Guénon; Snorri S Thorgeirsson; Anne Corlu; Bruno Clément
Hepatocyte-stellate cell cross-talk in the liver engenders a permissive inflammatory microenvironment that drives progression in hepatocellular carcinoma.
Cancer research 2012;72(10):2533-42.
2012: Takashi Ozaki; Samuel Refetoff; Jaime Rodriguez-Canales; Yoshihito Sasaki; Daekwan Seo; Snorri S Thorgeirsson; Jeffrey Hanson; Suguru Hayase; Kennichi Kakudo; Xiao-Hui Liao; Tsutomu Matsubara; Tsubasa Murata; Kunio Nagashima; Minoru Okamoto; Shioko Kimura
Thyroid regeneration: characterization of clear cells after partial thyroidectomy.
Endocrinology 2012;153(5):2514-25.
2012: Jesper B Andersen; Snorri S Thorgeirsson
Genetic profiling of intrahepatic cholangiocarcinoma.
Current opinion in gastroenterology 2012;28(3):266-72.
2012: Seung Bum Lee; Jens U Marquardt; Kye-Yoon Park; Daekwan Seo; Dongho Choi; Elizabeth A Conner; Valentina M Factor; Agnes Holczbauer; Snorri S Thorgeirsson
Contribution of hepatic lineage stage-specific donor memory to the differential potential of induced mouse pluripotent stem cells.
Stem cells (Dayton, Ohio) 2012;30(5):997-1007.
2012: Soo Mi Kim; Yoon Jun Kim; In-Sun Chu; Jeonghoon Heo; Ahmed Kaseb; Dae-Ghon Kim; Sang-Bae Kim; Sang Cheol Kim; Sun-Hee Leem; Jae Yun Lim; Eun Sung Park; Young Nyun Park; Yun-Yong Park; Snorri S Thorgeirsson; Xin Wei Wang; Ju Seog Lee
Sixty-five gene-based risk score classifier predicts overall survival in hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2012;55(5):1443-52.
2012: Hong-Wu Xin; Chenwi M Ambe; Andrew J Anderson; Susan H Garfield; Danielle M Hari; Tomotake Koizumi; John E Mullinax; Satyajit Ray; Snorri S Thorgeirsson; Gordon W Wiegand; Itzhak Avital
Tumor-initiating label-retaining cancer cells in human gastrointestinal cancers undergo asymmetric cell division.
Stem cells (Dayton, Ohio) 2012;30(4):591-8.
2012: Stephanie Roessler; Zhao-You Tang; Snorri S Thorgeirsson; Robert Walker; Qing-Hai Ye; Xuelian Zhao; Anuradha Budhu; Yidong Chen; Ping He; Kent W Hunter; Junfang Ji; Hu-Liang Jia; Ezhou Lori Long; Paul S Meltzer; Lun-Xiu Qin; Xin Wei Wang
Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival.
Gastroenterology 2012;142(4):957-966.e12.
2012: Jesper B andersen; Itzhak Avital; Andrew Barbour; Boris R Blechacz; Elizabeth A Conner; Valentina M Factor; Matthew C Gillen; Mina Komuta; Lewis R Roberts; Tania Roskams; Bart Spee; Snorri S Thorgeirsson
Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors.
Gastroenterology 2012;142(4):1021-1031.e15.
2012: Tsuyoshi Ishikawa; Mitsuteru Kitade; Jens U Marquardt; Chiara Raggi; Daekwan Seo; Elizabeth A Conner; Valentina M Factor; Snorri S Thorgeirsson
Hepatocyte growth factor/c-met signaling is required for stem-cell-mediated liver regeneration in mice.
Hepatology (Baltimore, Md.) 2012;55(4):1215-26.
2012: Xin Zheng; Natalia B Rumie Vittar; Abdirashid M Shire; Snorri S Thorgeirsson; Anne M Vrabel; Luciana L Almada; Andrea Comba; Sherine F Elsawa; Maite G Fernandez-Barrena; Martin E Fernandez Zapico; Xiaohong Gai; Chunling Hu; Youngsoo Kim; Qingguang Liu; Angela L McCleary-Wheeler; Catherine D Moser; Lewis R Roberts
The transcription factor GLI1 mediates TGFβ1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism.
PloS one 2012;7(11):e49581.
2011: Ju Dong Yang; In-Sun Chu; Yong Hoon Kim; Ju Seog Lee; Sun-Hee Leem; Lewis R Roberts; So-Young Seol; Zhifu Sun; Snorri S Thorgeirsson; Koo Jeong Kang
Genes associated with recurrence of hepatocellular carcinoma: integrated analysis by gene expression and methylation profiling.
Journal of Korean medical science 2011;26(11):1428-38.
2011: Y-H Lee; Ian MacLachlan; J U Marquardt; C Raggi; D Seo; Jesper B andersen; I Avital; E A Conner; Valentina M Factor; L E Gómez-Quiroz; T Ishikawa; A D Judge; B-K Kim; M Kitade; Snorri S Thorgeirsson
Molecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response.
Oncogene 2011;30(40):4175-84.
2011: Cedric Coulouarn; Valentina M Factor; Elizabeth A Conner; Snorri S Thorgeirsson
Genomic modeling of tumor onset and progression in a mouse model of aggressive human liver cancer.
Carcinogenesis 2011;32(10):1434-40.
2011: Patrick Viatour; Hannes Vogel; Anne-Flore Zmoos; Bethany E Schaffer; Karl G Sylvester; Snorri S Thorgeirsson; Jesper B andersen; Craig Dorrell; Ursula Ehmer; Markus Grompe; Chenwei Lin; Pawel K Mazur; Austin Ostermeier; Louis A Saddic; Julien Sage
Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.
The Journal of experimental medicine 2011;208(10):1963-76.
2011: Chang-il Hwang; Stefanie Körner; Andres Matoso; Carla Boccaccio; Paolo M Comoglio; David C Corney; Andrea Flesken-Nikitin; Heiko Hermeking; Snorri S Thorgeirsson; Wei Wang; Alexander Nikitin
Wild-type p53 controls cell motility and invasion by dual regulation of MET expression.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(34):14240-5.
2011: Snorri S Thorgeirsson
The almighty MYC: orchestrating the micro-RNA universe to generate aggressive liver cancer.
Journal of hepatology 2011;55(2):486-7.
2011: hyun goo woo; Eun Sung Park; Snorri S Thorgeirsson; Yoon Jun Kim
Exploring genomic profiles of hepatocellular carcinoma.
Molecular carcinogenesis 2011;50(4):235-43.
2011: Jimmy K Stauffer; Anthony J Scarzello; Jesper B andersen; Rachel L De Kluyver; Timothy C Back; Jonathan M Weiss; Snorri S Thorgeirsson; Robert H Wiltrout
Coactivation of AKT and β-catenin in mice rapidly induces formation of lipogenic liver tumors.
Cancer research 2011;71(7):2718-27.
2011: hyun goo woo; Xin Wei Wang; Anuradha Budhu; Yun Hee Kim; So Mee Kwon; Zhao-You Tang; Zongtang Sun; Curtis C Harris; Snorri S Thorgeirsson
Association of TP53 mutations with stem cell-like gene expression and survival of patients with hepatocellular carcinoma.
Gastroenterology 2011;140(3):1063-70.
2011: Ju Dong Yang; Zhifu Sun; Chunling Hu; Jinping Lai; Rebecca Dove; Ikuo Nakamura; Ju-Seog Lee; Snorri S Thorgeirsson; Koo Jeong Kang; In-Sun Chu; Lewis Roberts
Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: associated signaling pathways, tumor phenotypes, and survival.
Genes, chromosomes & cancer 2011;50(2):122-35.
2011: Diego F Calvisi; Sara Ladu; Elizabeth A Conner; Daekwan Seo; Jer-Tsong Hsieh; Valentina M Factor; Snorri S Thorgeirsson
Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer.
Journal of hepatology 2011;54(2):311-9.
2010: Stephanie Roessler; Hu-Liang Jia; Anuradha Budhu; Marshonna Forgues; Qing-Hai Ye; Ju-Seog Lee; Snorri S Thorgeirsson; Zhongtang Sun; Zhao-You Tang; Lun-Xiu Qin; Xin Wei Wang
A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients.
Cancer research 2010;70(24):10202-12.
2010: Yun-Han Lee; Jesper B andersen; Ho-Taek Song; Adam D Judge; Daekwan Seo; Tsuyoshi Ishikawa; Jens U Marquardt; Mitsuteru Kitade; Marian E Durkin; Chiara Raggi; hyun goo woo; Elizabeth A Conner; Itzhak Avital; Ian Maclachlan; Valentina M Factor; Snorri S Thorgeirsson
Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma.
Cancer research 2010;70(21):8264-9.
2010: Jesper B andersen; Valentina M Factor; Jens U Marquardt; Chiara Raggi; Yun-Han Lee; Daekwan Seo; Elizabeth A Conner; Snorri S Thorgeirsson
An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer.
Science translational medicine 2010;2(54):54ra77.
2010: J U Marquardt; Valentina M Factor; Snorri S Thorgeirsson
Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications.
Journal of hepatology 2010;53(3):568-77.
2010: André Schuster; Tobias Schilling; Vincenzo De Laurenzi; Andreas F Koch; Sarah Seitz; Frank Staib; Andreas Teufel; Snorri S Thorgeirsson; Peter Galle; Gerry Melino; Wolfgang Stremmel; Peter H Krammer; Martina Müller
ΔNp73β is oncogenic in hepatocellular carcinoma by blocking apoptosis signaling via death receptors and mitochondria.
Cell cycle (Georgetown, Tex.) 2010;9(13):2629-39.
2010: hyun goo woo; JH Lee; Jung-Hwan Yoon; Chung Yong Kim; Hyo-Suk Lee; Ja-June Jang; Nam-Joon Yi; Kyung-Suk Suh; Kuhn Uk Lee; Eun Sung Park; Snorri S Thorgeirsson; Yoon Jun Kim
Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma.
Cancer research 2010;70(8):3034-41.
2010: Jesper B andersen; Roberto Loi; Andrea Perra; Valentina M Factor; Giovanna M Ledda-Columbano; amedeo columbano; Snorri S Thorgeirsson
Progenitor-derived hepatocellular carcinoma model in the rat.
Hepatology (Baltimore, Md.) 2010;51(4):1401-9.
2010: Jens U Marquardt; Snorri S Thorgeirsson
Stem cells in hepatocarcinogenesis: evidence from genomic data.
Seminars in liver disease 2010;30(1):26-34.
2010: Valentina M Factor; Daekwan Seo; Tsuyoshi Ishikawa; Pal Kaposi-Novak; Jens U Marquardt; Jesper B andersen; Elizabeth A Conner; Snorri S Thorgeirsson
Loss of c-Met disrupts gene expression program required for G2/M progression during liver regeneration in mice.
PloS one 2010;5(9):.
2009: Cedric Coulouarn; Valentina M Factor; Jesper B andersen; Marian E Durkin; Snorri S Thorgeirsson
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties.
Oncogene 2009;28(40):3526-36.
2009: Drazen B Zimonjic; Xiaoling Zhou; Ju-Seog Lee; Veronika Ullmannova-Benson; Veenu Tripathi; Snorri S Thorgeirsson; Nicholas C Popescu
Acquired genetic and functional alterations associated with transforming growth factor beta type I resistance in Hep3B human hepatocellular carcinoma cell line.
Journal of cellular and molecular medicine 2009;13(9B):3985-92.
2009: Drazen Zimonjic; Veronika Ullmannova-Benson; Valentina M Factor; Snorri S Thorgeirsson; Nicholas C Popescu
Recurrent and nonrandom DNA copy number and chromosome alterations in Myc transgenic mouse model for hepatocellular carcinogenesis: implications for human disease.
Cancer genetics and cytogenetics 2009;191(1):17-26.
2009: hyun goo woo; Eun Sung Park; Ju Seog Lee; Yun-Han Lee; Tsuyoshi Ishikawa; Yoon Jun Kim; Snorri S Thorgeirsson
Identification of potential driver genes in human liver carcinoma by genomewide screening.
Cancer research 2009;69(9):4059-66.
2009: Xin Wei Wang; Snorri S Thorgeirsson
Transcriptome analysis of liver cancer: ready for the clinic?
Journal of hepatology 2009;50(5):1062-4.
2009: Pal Kaposi-Novak; Louis Libbrecht; hyun goo woo; Yun-Han Lee; Nathaniel C Sears; Cedric Coulouarn; Elizabeth A Conner; Valentina M Factor; Tania Roskams; Snorri S Thorgeirsson
Central role of c-Myc during malignant conversion in human hepatocarcinogenesis.
Cancer research 2009;69(7):2775-82.
2008: Viktória László; Katalin Dezso; Kornélia Baghy; Veronika Papp; ilona kovalszky; Géza Sáfrány; Snorri S Thorgeirsson; Péter Nagy; Sándor Paku
Triiodothyronine accelerates differentiation of rat liver progenitor cells into hepatocytes.
Histochemistry and cell biology 2008;130(5):1005-14.
2008: Sara Ladu; Diego F Calvisi; Elizabeth A Conner; Miriam Farina; Valentina M Factor; Snorri S Thorgeirsson
E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer.
Gastroenterology 2008;135(4):1322-32.
2008: Cedric Coulouarn; Valentina M Factor; Snorri S Thorgeirsson
Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer.
Hepatology (Baltimore, Md.) 2008;47(6):2059-67.
2008: Luis E Gómez-Quiroz; Valentina M Factor; Pal Kaposi-Novak; Cedric Coulouarn; Elizabeth A Conner; Snorri S Thorgeirsson
Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosis.
The Journal of biological chemistry 2008;283(21):14581-9.
2008: Gaelle del Castillo; Valentina M Factor; Margarita Fernández; Alberto Alvarez-Barrientos; Isabel Fabregat; Snorri S Thorgeirsson; Aránzazu Sánchez
Deletion of the Met tyrosine kinase in liver progenitor oval cells increases sensitivity to apoptosis in vitro.
The American journal of pathology 2008;172(5):1238-47.
2008: hyun goo woo; Eun Sung Park; Jae Hee Cheon; Ju Han Kim; Ju Seog Lee; Bum Joon Park; Won Kim; Su Cheol Park; Young Jin Chung; Byeong Gwan Kim; Jung-Hwan Yoon; Hyo-Suk Lee; Chung Yong Kim; Nam-Joon Yi; Kyung-Suk Suh; Kuhn Uk Lee; In-Sun Chu; Tania Roskams; Snorri S Thorgeirsson; Yoon Jun Kim
Gene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(7):2056-64.
2008: Jin-Ping Lai; Dalbir S Sandhu; Chunrong Yu; Tao Han; Catherine D Moser; Kenard K Jackson; Ruben Bonilla Guerrero; Ileana Aderca; Hajime Isomoto; Megan M Garrity-Park; Hongzhi Zou; Abdirashid M Shire; David M Nagorney; Schuyler O Sanderson; Alex A. Adjei; Ju Seog Lee; Snorri S Thorgeirsson; Lewis Roberts
Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2008;47(4):1211-22.
2007: Taro Takami; Pal Kaposi-Novak; Koichi Uchida; Luis E Gomez-Quiroz; Elizabeth A Conner; Valentina M Factor; Snorri S Thorgeirsson
Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis.
Cancer research 2007;67(20):9844-51.
2007: Marian E Durkin; Bao-Zhu Yuan; Xiaoling Zhou; Drazen Zimonjic; Douglas Lowy; Snorri S Thorgeirsson; Nicholas C Popescu
DLC-1:a Rho GTPase-activating protein and tumour suppressor.
Journal of cellular and molecular medicine 2007;11(5):1185-207.
2007: Christopher N Mayhew; Scott L Carter; Sejal R Fox; Charlene R Sexton; Christopher A Reed; Seetha V Srinivasan; Xiangdong Liu; Kathryn Ann Wikenheiser-Brokamp; Gregory P Boivin; Ju Seog Lee; Bruce Aronow; Snorri S Thorgeirsson; Erik S Knudsen
RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis.
Gastroenterology 2007;133(3):976-84.
2007: Diego F Calvisi; Sara Ladu; Alexis Gorden; Miriam Farina; Ju Seog Lee; Elizabeth A Conner; Insa S Schroeder; Valentina M Factor; Snorri S Thorgeirsson
Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma.
The Journal of clinical investigation 2007;117(9):2713-22.
2007: Sigal Kremer-Tal; Goutham Narla; Ying-bei Chen; Eldad Hod; Analisa Difeo; Steven Yea; Ju Seog Lee; Myron Schwartz; Swan N Thung; Isabel M Fiel; Michaela S Banck; Eran Zimran; Snorri S Thorgeirsson; Vincenzo Mazzaferro; Jordi Bruix; John A Martignetti; Josep M Llovet; Scott L Friedman
Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation.
Journal of hepatology 2007;46(4):645-54.
2006: Jeonghoon Heo; Valentina M Factor; Tania Uren; Yasushi Takahama; Ju Seog Lee; Marian E Major; Stephen M Feinstone; Snorri S Thorgeirsson
Hepatic precursors derived from murine embryonic stem cells contribute to regeneration of injured liver.
Hepatology (Baltimore, Md.) 2006;44(6):1478-86.
2006: Snorri S Thorgeirsson
Genomic decoding of hepatocellular carcinoma.
Gastroenterology 2006;131(4):1344-6.
2006: Cedric Coulouarn; Luis E Gomez-Quiroz; Ju Seog Lee; Pal Kaposi-Novak; Elizabeth A Conner; Tatyana A Goldina; Galina E Onishchenko; Valentina M Factor; Snorri S Thorgeirsson
Oncogene-specific gene expression signatures at preneoplastic stage in mice define distinct mechanisms of hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 2006;44(4):1003-11.
2006: Ju Seog Lee; Snorri S Thorgeirsson
Comparative and integrative functional genomics of HCC.
Oncogene 2006;25(27):3801-9.
2006: Juliette Martin; Fabrice Magnino; Karin Schmidt; Anne-Christine Piguet; Ju Seog Lee; David Semela; Marie V St Pierre; Andrew Ziemiecki; Doris Cassio; Charles Brenner; Snorri S Thorgeirsson; Jean-François Dufour
Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma.
Gastroenterology 2006;130(7):2179-88.
2006: Pal Kaposi-Novak; Ju Seog Lee; Luis Gòmez-Quiroz; Cedric Coulouarn; Valentina M Factor; Snorri S Thorgeirsson
Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype.
The Journal of clinical investigation 2006;116(6):1582-95.
2006: Diego F Calvisi; Sara Ladu; Alexis Gorden; Miriam Farina; Elizabeth A Conner; Ju Seog Lee; Valentina M Factor; Snorri S Thorgeirsson
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC.
Gastroenterology 2006;130(4):1117-28.
2006: Ju Seog Lee; Jeonghoon Heo; Louis Libbrecht; In-Sun Chu; Pal Kaposi-Novak; Diego F Calvisi; Arsen Mikaelyan; Lewis Roberts; Anthony J Demetris; Zongtang Sun; Frederik Nevens; Tania Roskams; Snorri S Thorgeirsson
A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells.
Nature medicine 2006;12(4):410-6.
2006: Snorri S Thorgeirsson; Ju Seog Lee; Joe W Grisham
Molecular prognostication of liver cancer: end of the beginning.
Journal of hepatology 2006;44(4):798-805.
2006: Snorri S Thorgeirsson; Ju Seog Lee; Joe W Grisham
Functional genomics of hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2006;43(2 Suppl 1):S145-50.
2006: Snorri S Thorgeirsson; Joe W Grisham
Hematopoietic cells as hepatocyte stem cells: a critical review of the evidence.
Hepatology (Baltimore, Md.) 2006;43(1):2-8.
2005: Rosa M Pascale; Maria M Simile; Diego F Calvisi; Maddalena Frau; Maria R Muroni; Maria A Seddaiu; Lucia Daino; Maria D Muntoni; Maria R De Miglio; Snorri S Thorgeirsson; Francesco Feo
Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer.
Hepatology (Baltimore, Md.) 2005;42(6):1310-9.
2005: May Tassabehji; Peter Hammond; Annette Karmiloff-Smith; Pamela Thompson; Snorri S Thorgeirsson; Marian E Durkin; Nicholas C Popescu; Tim J Hutton; Kay Metcalfe; Agnes Rucka; Helen Stewart; Andrew P Read; Mark Maconochie; Dian Donnai
GTF2IRD1 in craniofacial development of humans and mice.
Science (New York, N.Y.) 2005;310(5751):1184-7.
2005: Eric Santoni-Rugiu; Peter Jelnes; Snorri S Thorgeirsson; Hanne Cathrine Bisgaard
Progenitor cells in liver regeneration: molecular responses controlling their activation and expansion.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2005;113(11-12):876-902.
2005: Chunsun Dai; Chang-Goo Huh; Snorri S Thorgeirsson; Youhua Liu
Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance.
The American journal of pathology 2005;167(2):429-36.
2005: Jeonghoon Heo; Ju Seog Lee; In-Sun Chu; Yasushi Takahama; Snorri S Thorgeirsson
Spontaneous differentiation of mouse embryonic stem cells in vitro: characterization by global gene expression profiles.
Biochemical and biophysical research communications 2005;332(4):1061-9.
2005: Lakita G Cavin; Fang Wang; Valentina M Factor; Swayamjot Kaur; Manickam Venkatraman; Snorri S Thorgeirsson; Marcello Arsura
Transforming growth factor-alpha inhibits the intrinsic pathway of c-Myc-induced apoptosis through activation of nuclear factor-kappaB in murine hepatocellular carcinomas.
Molecular cancer research : MCR 2005;3(7):403-12.
2005: Diego F Calvisi; Elizabeth A Conner; Sara Ladu; Eric R Lemmer; Valentina M Factor; Snorri S Thorgeirsson
Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer.
Journal of hepatology 2005;42(6):842-9.
2005: Ju Seog Lee; Joe W Grisham; Snorri S Thorgeirsson
Comparative functional genomics for identifying models of human cancer.
Carcinogenesis 2005;26(6):1013-20.
2005: Göran Karlsson; Yingchun Liu; Jonas Larsson; Marie-José Goumans; Ju Seog Lee; Snorri S Thorgeirsson; Markus Ringnér; Stefan Karlsson
Gene expression profiling demonstrates that TGF-beta1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF-beta signaling.
Physiological genomics 2005;21(3):396-403.
2005: Taro Takami; Shuji Terai; Yuichiro Yokoyama; Haruko Tanimoto; Kunihiko Tajima; Koichi Uchida; Takahiro Yamasaki; Isao Sakaida; Hiroshi Nishina; Snorri S Thorgeirsson; Kiwamu Okita
Human homologue of maid is a useful marker protein in hepatocarcinogenesis.
Gastroenterology 2005;128(5):1369-80.
2005: Marian E Durkin; Miriam R Avner; Chang-Goo Huh; Bao-Zhu Yuan; Snorri S Thorgeirsson; Nicholas C Popescu
DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development.
FEBS letters 2005;579(5):1191-6.
2005: Ju Seog Lee; Snorri S Thorgeirsson
Genetic profiling of human hepatocellular carcinoma.
Seminars in liver disease 2005;25(2):125-32.
2005: Diego F Calvisi; Snorri S Thorgeirsson
Molecular mechanisms of hepatocarcinogenesis in transgenic mouse models of liver cancer.
Toxicologic pathology 2005;33(1):181-4.
2004: Ju Seog Lee; In-Sun Chu; Arsen Mikaelyan; Diego F Calvisi; Jeonghoon Heo; Janardan K Reddy; Snorri S Thorgeirsson
Application of comparative functional genomics to identify best-fit mouse models to study human cancer.
Nature genetics 2004;36(12):1306-11.
2004: Diego F Calvisi; Sara Ladu; Koji Hironaka; Valentina M Factor; Snorri S Thorgeirsson
Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-alpha transgenic mouse model of liver cancer.
Journal of hepatology 2004;41(5):815-22.
2004: Ju Seog Lee; Snorri S Thorgeirsson
Genome-scale profiling of gene expression in hepatocellular carcinoma: classification, survival prediction, and identification of therapeutic targets.
Gastroenterology 2004;127(5 Suppl 1):S51-5.
2004: Shoshiro Oe; Eric R Lemmer; Elizabeth A Conner; Valentina M Factor; Per Levéen; Jonas Larsson; Stefan Karlsson; Snorri S Thorgeirsson
Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice.
Hepatology (Baltimore, Md.) 2004;40(5):1098-105.
2004: Geoung A Jeon; Ju Seog Lee; Vyomesh Patel; J Silvio Gutkind; Snorri S Thorgeirsson; Eun-Cheol Kim; In-Sun Chu; Panomwat Amornphimoltham; Myung Hee Park
Global gene expression profiles of human head and neck squamous carcinoma cell lines.
International journal of cancer. Journal international du cancer 2004;112(2):249-58.
2004: Pal Kaposi-Novak; Ju Seog Lee; Arsen Mikaelyan; Vyomesh Patel; Snorri S Thorgeirsson
Oligonucleotide microarray analysis of aminoallyl-labeled cDNA targets from linear RNA amplification.
BioTechniques 2004;37(4):580, 582-6, 588.
2004: Lakita G Cavin; Manickam Venkatraman; Valentina M Factor; Swayamjot Kaur; Insa S Schroeder; Frank Mercurio; Amer A Beg; Snorri S Thorgeirsson; Marcello Arsura
Regulation of alpha-fetoprotein by nuclear factor-kappaB protects hepatocytes from tumor necrosis factor-alpha cytotoxicity during fetal liver development and hepatic oncogenesis.
Cancer research 2004;64(19):7030-8.
2004: Ju Seog Lee; In-Sun Chu; Jeonghoon Heo; Diego F Calvisi; Zongtang Sun; Tania Roskams; Anne Durnez; Anthony J Demetris; Snorri S Thorgeirsson
Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling.
Hepatology (Baltimore, Md.) 2004;40(3):667-76.
2004: Aránzazu Sánchez; Valentina M Factor; Luis A Espinoza; Insa S Schroeder; Snorri S Thorgeirsson
In vitro differentiation of rat liver derived stem cells results in sensitization to TNFalpha-mediated apoptosis.
Hepatology (Baltimore, Md.) 2004;40(3):590-9.
2004: Diego F Calvisi; Sara Ladu; Elizabeth A Conner; Valentina M Factor; Snorri S Thorgeirsson
Disregulation of E-cadherin in transgenic mouse models of liver cancer.
Laboratory investigation; a journal of technical methods and pathology 2004;84(9):1137-47.
2004: Masaharu Yamazaki; Takemi Akahane; Todd Buck; Hitoshi Yoshiji; daniel gomez; Daniel J Schoeffner; Eijiro Okajima; Steven R Harris; Opal R Bunce; Snorri S Thorgeirsson; Unnur P Thorgeirsson
Long-term exposure to elevated levels of circulating TIMP-1 but not mammary TIMP-1 suppresses growth of mammary carcinomas in transgenic mice.
Carcinogenesis 2004;25(9):1735-46.
2004: Thorunn Rafnar; Steinunn Thorlacius; Eirikur Steingrimsson; Mikkel H Schierup; Jesper N Madsen; Violeta Calian; Bjarki Jónsson Eldon; Thorvaldur Jonsson; Jotun Hein; Snorri S Thorgeirsson
The Icelandic Cancer Project--a population-wide approach to studying cancer.
Nature reviews. Cancer 2004;4(6):488-92.
2004: Diego F Calvisi; Sara Ladu; Valentina M Factor; Snorri S Thorgeirsson
Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital.
Carcinogenesis 2004;25(6):901-8.
2004: Diego F Calvisi; Valentina M Factor; Sara Ladu; Elizabeth A Conner; Snorri S Thorgeirsson
Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice.
Gastroenterology 2004;126(5):1374-86.
2004: Sándor Paku; Péter Nagy; László Kopper; Snorri S Thorgeirsson
2-acetylaminofluorene dose-dependent differentiation of rat oval cells into hepatocytes: confocal and electron microscopic studies.
Hepatology (Baltimore, Md.) 2004;39(5):1353-61.
2004: Chang-Goo Huh; Valentina M Factor; Aránzazu Sánchez; Koichi Uchida; Elizabeth A Conner; Snorri S Thorgeirsson
Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4477-82.
2004: Bao-Zhu Yuan; Amy M Jefferson; Kimberly T Baldwin; Snorri S Thorgeirsson; Nicholas C Popescu; Steven H Reynolds
DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas.
Oncogene 2004;23(7):1405-11.
2004: Natasha G Deane; Haakil Lee; Jalal Hamaamen; Anna Ruley; M Kay Washington; Bonnie J Lafleur; Snorri S Thorgeirsson; Ronald Price; R Daniel Beauchamp
Enhanced tumor formation in cyclin D1 x transforming growth factor beta1 double transgenic mice with characterization by magnetic resonance imaging.
Cancer research 2004;64(4):1315-22.
2004: Xiaoling Zhou; Snorri S Thorgeirsson; Nicholas C Popescu
Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells.
Oncogene 2004;23(6):1308-13.
2004: János Schnur; Julianna Oláh; Ágota Szepesi; Péter Nagy; Snorri S Thorgeirsson
Thioacetamide-induced hepatic fibrosis in transforming growth factor beta-1 transgenic mice.
European journal of gastroenterology & hepatology 2004;16(2):127-33.
2004: Aránzazu Sánchez; Valentina M Factor; Insa S Schroeder; Péter Nagy; Snorri S Thorgeirsson
Activation of NF-kappaB and STAT3 in rat oval cells during 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration.
Hepatology (Baltimore, Md.) 2004;39(2):376-85.
2003: Lakita G Cavin; Raphaëlle Romieu-Mourez; Ganesh R Panta; Jiyuan Sun; Valentina M Factor; Snorri S Thorgeirsson; Gail E Sonenshein; Marcello Arsura
Inhibition of CK2 activity by TGF-beta1 promotes IkappaB-alpha protein stabilization and apoptosis of immortalized hepatocytes.
Hepatology (Baltimore, Md.) 2003;38(6):1540-51.
2003: Snorri S Thorgeirsson; Joe W Grisham
Overview of recent experimental studies on liver stem cells.
Seminars in liver disease 2003;23(4):303-12.
2003: Drazen Zimonjic; Marian E Durkin; Catherine L Keck-Waggoner; Sang-Won Park; Snorri S Thorgeirsson; Nicholas C Popescu
SMAD5 gene expression, rearrangements, copy number, and amplification at fragile site FRA5C in human hepatocellular carcinoma.
Neoplasia (New York, N.Y.) 2003;5(5):390-6.
2003: Aránzazu Sánchez; Péter Nagy; Snorri S Thorgeirsson
STAT-3 activity in chemically-induced hepatocellular carcinoma.
European journal of cancer (Oxford, England : 1990) 2003;39(14):2093-8.
2003: Sang-Won Park; Marian E Durkin; Snorri S Thorgeirsson; Nicholas C Popescu
DNA variants of DLC-1, a candidate tumor suppressor gene in human hepatocellular carcinoma.
International journal of oncology 2003;23(1):133-7.
2003: Kirstin Meyer; Ju Seog Lee; Patricia A Dyck; Wen-Qing Cao; M Sambasiva Rao; Snorri S Thorgeirsson; Janardan K Reddy
Molecular profiling of hepatocellular carcinomas developing spontaneously in acyl-CoA oxidase deficient mice: comparison with liver tumors induced in wild-type mice by a peroxisome proliferator and a genotoxic carcinogen.
Carcinogenesis 2003;24(5):975-84.
2003: Koji Hironaka; Valentina M Factor; Diego F Calvisi; Elizabeth A Conner; Snorri S Thorgeirsson
Dysregulation of DNA repair pathways in a transforming growth factor alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis.
Laboratory investigation; a journal of technical methods and pathology 2003;83(5):643-54.
2003: Michael Rugaard Jensen; Valentina M Factor; A Fantozzi; Kristian Helin; Chang-Goo Huh; Snorri S Thorgeirsson
Reduced hepatic tumor incidence in cyclin G1-deficient mice.
Hepatology (Baltimore, Md.) 2003;37(4):862-70.
2003: Snorri S Thorgeirsson
Hunting for tumor suppressor genes in liver cancer.
Hepatology (Baltimore, Md.) 2003;37(4):739-41.
2003: Elizabeth A Conner; Eric R Lemmer; Aránzazu Sánchez; Valentina M Factor; Snorri S Thorgeirsson
E2F1 blocks and c-Myc accelerates hepatic ploidy in transgenic mouse models.
Biochemical and biophysical research communications 2003;302(1):114-20.
2003: Bao-Zhu Yuan; Xiaoling Zhou; Marian E Durkin; Drazen Zimonjic; Katrin Gumundsdottir; Jorunn E Eyfjord; Snorri S Thorgeirsson; Nicholas C Popescu
DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity.
Oncogene 2003;22(3):445-50.
2003: Marcello Arsura; Ganesh R Panta; Jennifer D Bilyeu; Lakita G Cavin; Mika A Sovak; Aundrea A Oliver; Valentina M Factor; Rainer Heuchel; Frank Mercurio; Snorri S Thorgeirsson; Gail E Sonenshein
Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation.
Oncogene 2003;22(3):412-25.
2002: Lihua Ming; Snorri S Thorgeirsson; Mitchell H Gail; Peixin Lu; Curtis C Harris; Nengjin Wang; Yongfu Shao; Zhiyuan Wu; Guoting Liu; Xiaohong Wang; Zongtang Sun
Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China.
Hepatology (Baltimore, Md.) 2002;36(5):1214-20.
2002: Snorri S Thorgeirsson; Joe W Grisham
Molecular pathogenesis of human hepatocellular carcinoma.
Nature genetics 2002;31(4):339-46.
2002: Ju Seog Lee; Snorri S Thorgeirsson
Functional and genomic implications of global gene expression profiles in cell lines from human hepatocellular cancer.
Hepatology (Baltimore, Md.) 2002;35(5):1134-43.
2002: Marian E Durkin; Bao-Zhu Yuan; Snorri S Thorgeirsson; Nicholas C Popescu
Gene structure, tissue expression, and linkage mapping of the mouse DLC-1 gene (Arhgap7).
Gene 2002;288(1-2):119-27.
2002: Koji Okamoto; Hongyun Li; Michael Rugaard Jensen; Tingting Zhang; Yoichi Taya; Snorri S Thorgeirsson; Carol Prives
Cyclin G recruits PP2A to dephosphorylate Mdm2.
Molecular cell 2002;9(4):761-71.
2001: YH Im; Heung Tae Kim; Isaac Yi Kim; Valentina M Factor; Ki-Baik Hahm; Mario A Anzano; Ja-June Jang; Kathleen C Flanders; Diana C Haines; Snorri S Thorgeirsson; A Sizeland; Seong-Jin Kim
Heterozygous mice for the transforming growth factor-beta type II receptor gene have increased susceptibility to hepatocellular carcinogenesis.
Cancer research 2001;61(18):6665-8.
2001: Valentina M Factor; A L Oliver; Ganesh R Panta; Snorri S Thorgeirsson; Gail E Sonenshein; Marcello Arsura
Roles of Akt/PKB and IKK complex in constitutive induction of NF-kappaB in hepatocellular carcinomas of transforming growth factor alpha/c-myc transgenic mice.
Hepatology (Baltimore, Md.) 2001;34(1):32-41.
2001: A Kiss; R Ortiz-Aguayo; Richard Sharp; Glenn Merlino; Snorri S Thorgeirsson; Frank J Gonzalez; Jeffrey M Peters
Evidence that reduction of hepatocyte growth factor (HGF) is not required for peroxisome proliferator-induced hepatocyte proliferation.
Carcinogenesis 2001;22(6):975-9.
2001: Marian E Durkin; Catherine L Keck-Waggoner; Nicholas C Popescu; Snorri S Thorgeirsson
Integration of a c-myc transgene results in disruption of the mouse Gtf2ird1 gene, the homologue of the human GTF2IRD1 gene hemizygously deleted in Williams-Beuren syndrome.
Genomics 2001;73(1):20-7.
2001: Sándor Paku; János Schnur; Péter Nagy; Snorri S Thorgeirsson
Origin and structural evolution of the early proliferating oval cells in rat liver.
The American journal of pathology 2001;158(4):1313-23.
2001: Diego F Calvisi; Valentina M Factor; R Loi; Snorri S Thorgeirsson
Activation of beta-catenin during hepatocarcinogenesis in transgenic mouse models: relationship to phenotype and tumor grade.
Cancer research 2001;61(5):2085-91.
2001: Péter Nagy; T Teramoto; V M Factor; A Sanchez; János Schnur; Sándor Paku; Snorri S Thorgeirsson
Reconstitution of liver mass via cellular hypertrophy in the rat.
Hepatology (Baltimore, Md.) 2001;33(2):339-45.
2001: Drazen Zimonjic; H Zhang; Z Shan; Valentina M Factor; Jeffrey M. Trent; Snorri S Thorgeirsson; Nicholas C Popescu
DNA amplification associated with double minutes originating from chromosome 19 in mouse hepatocellular carcinoma.
Cytogenetics and cell genetics 2001;93(1-2):114-6.
2000: Elizabeth A Conner; Eric R Lemmer; M Omori; PJ Wirth; Valentina M Factor; Snorri S Thorgeirsson
Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis.
Oncogene 2000;19(44):5054-62.
2000: Michael Rugaard Jensen; T Audolfsson; Valentina M Factor; Snorri S Thorgeirsson
In vivo expression and genomic organization of the mouse cyclin I gene (Ccni).
Gene 2000;256(1-2):59-67.
2000: S Terai; H Aoki; K Ashida; Snorri S Thorgeirsson
Human homologue of maid: A dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression.
Hepatology (Baltimore, Md.) 2000;32(2):357-66.
2000: Marcello Arsura; Frank Mercurio; A L Oliver; Snorri S Thorgeirsson; Gail E Sonenshein
Role of the IkappaB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells.
Molecular and cellular biology 2000;20(15):5381-91.
2000: S Sanders; Snorri S Thorgeirsson
Promotion of hepatocarcinogenesis by phenobarbital in c-myc/TGF-alpha transgenic mice.
Molecular carcinogenesis 2000;28(3):168-73.
2000: Péter Nagy; Hanne Cathrine Bisgaard; János Schnur; Snorri S Thorgeirsson
Studies on hepatic gene expression in different liver regenerative models.
Biochemical and biophysical research communications 2000;272(2):591-5.
2000: Snorri S Thorgeirsson; Valentina M Factor; Elizabeth G Snyderwine
Transgenic mouse models in carcinogenesis research and testing.
Toxicology letters 2000;112-113():553-5.
2000: Valentina M Factor; D Laskowska; Michael Rugaard Jensen; JT Woitach; Nicholas C Popescu; Snorri S Thorgeirsson
Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2196-201.
2000: Bao-Zhu Yuan; Catherine L Keck-Waggoner; Drazen Zimonjic; Snorri S Thorgeirsson; Nicholas C Popescu
Alterations of the FHIT gene in human hepatocellular carcinoma.
Cancer research 2000;60(4):1049-53.
2000: Eric R Lemmer; J L Welch; T Tsai; Catherine L Keck-Waggoner; C Huh; Drazen Zimonjic; Nicholas C Popescu; Snorri S Thorgeirsson
Genomic structure and chromosome location of the mouse RelA p65 gene (Rela).
Cytogenetics and cell genetics 2000;89(1-2):129-32.
2000: S Sanders; Catherine L Keck-Waggoner; Drazen Zimonjic; Nicholas C Popescu; Snorri S Thorgeirsson
Assignment of WDR7 (alias TRAG, TGF-beta resistance associated gene) to orthologous regions of human chromosome 18q21.1-->q22 and mouse chromosome 18D.1-E.3 by fluorescence in situ hybridization.
Cytogenetics and cell genetics 2000;88(3-4):324-5.
1999: János Schnur; Péter Nagy; Anna Sebestyén; Zsuzsa Schaff; Snorri S Thorgeirsson
Chemical hepatocarcinogenesis in transgenic mice overexpressing mature TGF beta-1 in liver.
European journal of cancer (Oxford, England : 1990) 1999;35(13):1842-5.
1999: Snorri S Thorgeirsson; DY Ryu; V Weidner; Elizabeth G Snyderwine
Carcinogenicity and mutagenicity of heterocyclic amines in transgenic mouse models.
Cancer letters 1999;143(2):245-7.
1999: Kumiko Ogawa; Hiroyuki Tsuda; Tomoyuki Shirai; Tadashi Ogiso; K Wakabayashi; DW Dalgard; Unnur P Thorgeirsson; Snorri S Thorgeirsson; RH Adamson; T Sugimura
Lack of carcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in cynomolgus monkeys.
Japanese journal of cancer research : Gann 1999;90(6):622-8.
1999: E Santoni-Rugiu; Michael Rugaard Jensen; Valentina M Factor; Snorri S Thorgeirsson
Acceleration of c-myc-induced hepatocarcinogenesis by Co-expression of transforming growth factor (TGF)-alpha in transgenic mice is associated with TGF-beta1 signaling disruption.
The American journal of pathology 1999;154(6):1693-700.
1999: C L Keck; Drazen Zimonjic; Bao-Zhu Yuan; Snorri S Thorgeirsson; Nicholas C Popescu
Nonrandom breakpoints of unbalanced chromosome translocations in human hepatocellular carcinoma cell lines.
Cancer genetics and cytogenetics 1999;111(1):37-44.
1999: Michael Rugaard Jensen; T Audolfsson; CL Keck; Drazen Zimonjic; Snorri S Thorgeirsson
Gene structure and chromosomal localization of mouse cyclin G2 (Ccng2).
Gene 1999;230(2):171-80.
1999: Linda M Sargent; X Zhou; C L Keck; N D Sanderson; Drazen Zimonjic; Nicholas C Popescu; Snorri S Thorgeirsson
Nonrandom cytogenetic alterations in hepatocellular carcinoma from transgenic mice overexpressing c-Myc and transforming growth factor-alpha in the liver.
The American journal of pathology 1999;154(4):1047-55.
1999: Elizabeth A Conner; T Teramoto; PJ Wirth; A Kiss; S Garfield; Snorri S Thorgeirsson
HGF-mediated apoptosis via p53/bax-independent pathway activating JNK1.
Carcinogenesis 1999;20(4):583-90.
1999: Drazen Zimonjic; C L Keck; Snorri S Thorgeirsson; Nicholas C Popescu
Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization.
Hepatology (Baltimore, Md.) 1999;29(4):1208-14.
1999: K H Preisegger; Valentina M Factor; Andrea Fuchsbichler; Conny Stumptner; Helmut Denk; Snorri S Thorgeirsson
Atypical ductular proliferation and its inhibition by transforming growth factor beta1 in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine mouse model for chronic alcoholic liver disease.
Laboratory investigation; a journal of technical methods and pathology 1999;79(2):103-9.
1999: Bao-Zhu Yuan; Youfeng Yang; Catherine L Keck-Waggoner; Drazen Zimonjic; Snorri S Thorgeirsson; Nicholas C Popescu
Assignment and cloning of mouse Arhgap7 to chromosome 8A4-B2, a conserved syntenic region of human chromosome 8p22-->p21.
Cytogenetics and cell genetics 1999;87(3-4):189-90.
1999: JT Woitach; R Hong; CL Keck; Drazen Zimonjic; Nicholas C Popescu; Snorri S Thorgeirsson
Assignment of the Bog gene (RBBP9) to syntenic regions of mouse chromosome 2G1-H1 and human chromosome 20p11.2 by fluorescence in situ hybridization.
Cytogenetics and cell genetics 1999;85(3-4):252-3.
1999: S Sanders; Snorri S Thorgeirsson
Phenobarbital promotes liver growth in c-myc/TGF-alpha transgenic mice by inducing hypertrophy and inhibiting apoptosis.
Carcinogenesis 1999;20(1):41-9.
1998: Snorri S Thorgeirsson; H Okayama
The United States-Japan Cooperative Cancer Research Program seminar on "Cell cycle control and cancer".
Japanese journal of cancer research : Gann 1998;89(10):1093-7.
1998: JT Woitach; M Zhang; C H Niu; Snorri S Thorgeirsson
A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability.
Nature genetics 1998;19(4):371-4.
1998: Michael Rugaard Jensen; Valentina M Factor; Snorri S Thorgeirsson
Regulation of cyclin G1 during murine hepatic regeneration following Dipin-induced DNA damage.
Hepatology (Baltimore, Md.) 1998;28(2):537-46.
1998: Valentina M Factor; A Kiss; JT Woitach; PJ Wirth; Snorri S Thorgeirsson
Disruption of redox homeostasis in the transforming growth factor-alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis.
The Journal of biological chemistry 1998;273(25):15846-53.
1998: Bao-Zhu Yuan; M J Miller; C L Keck; Drazen Zimonjic; Snorri S Thorgeirsson; Nicholas C Popescu
Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP.
Cancer research 1998;58(10):2196-9.
1998: Hanne Cathrine Bisgaard; Eric Santoni-Rugiu; Péter Nagy; Snorri S Thorgeirsson
Modulation of the plasminogen activator/plasmin system in rat liver regenerating by recruitment of oval cells.
Laboratory investigation; a journal of technical methods and pathology 1998;78(3):237-46.
1998: Michael Rugaard Jensen; T Audolfsson; CL Keck; Drazen Zimonjic; Snorri S Thorgeirsson
Assignment of the cyclin I gene (Ccni) to mouse chromosome 5E3.3-F1. 3 by in situ hybridization.
Cytogenetics and cell genetics 1998;83(3-4):242-3.
1998: Snorri S Thorgeirsson; T Teramoto; Valentina M Factor
Dysregulation of apoptosis in hepatocellular carcinoma.
Seminars in liver disease 1998;18(2):115-22.
1998: SS Dadras; Snorri S Thorgeirsson; M Sambasiva Rao; Janardan K Reddy
Implication of hydrogen peroxide generation and apoptosis in the neoplastic transformation of mouse fibroblasts overexpressing peroxisomal fatty acyl-CoA oxidase.
International journal of oncology 1998;12(1):37-44.
1998: E Santoni-Rugiu; Michael Rugaard Jensen; Snorri S Thorgeirsson
Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha.
Cancer research 1998;58(1):123-34.
1997: Valentina M Factor; Michael Rugaard Jensen; Snorri S Thorgeirsson
Coexpression of C-myc and transforming growth factor alfa in the liver promotes early replicative senescence and diminishes regenerative capacity after partial hepatectomy in transgenic mice.
Hepatology (Baltimore, Md.) 1997;26(6):1434-43.
1997: Michael Rugaard Jensen; Valentina M Factor; Drazen Zimonjic; M J Miller; CL Keck; Snorri S Thorgeirsson
Chromosome localization and structure of the murine cyclin G1 gene promoter sequence.
Genomics 1997;45(2):297-303.
1997: N Omori; M Omori; RP Evarts; T Teramoto; M J Miller; T N Hoang; Snorri S Thorgeirsson
Partial cloning of rat CD34 cDNA and expression during stem cell-dependent liver regeneration in the adult rat.
Hepatology (Baltimore, Md.) 1997;26(3):720-7.
1997: Elizabeth A Conner; PJ Wirth; A Kiss; E Santoni-Rugiu; Snorri S Thorgeirsson
Growth inhibition and induction of apoptosis by HGF in transformed rat liver epithelial cells.
Biochemical and biophysical research communications 1997;236(2):396-401.
1997: A Kiss; N J Wang; J P Xie; Snorri S Thorgeirsson
Analysis of transforming growth factor (TGF)-alpha/epidermal growth factor receptor, hepatocyte growth Factor/c-met,TGF-beta receptor type II, and p53 expression in human hepatocellular carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(7):1059-66.
1997: Valentina M Factor; C Y Kao; E Santoni-Rugiu; JT Woitach; Michael Rugaard Jensen; Snorri S Thorgeirsson
Constitutive expression of mature transforming growth factor beta1 in the liver accelerates hepatocarcinogenesis in transgenic mice.
Cancer research 1997;57(11):2089-95.
1997: Snorri S Thorgeirsson; E Santoni-Rugiu
Interaction of c-myc with transforming growth factor alpha and hepatocyte growth factor in hepatocarcinogenesis.
Mutation research 1997;376(1-2):221-34.
1997: Elizabeth G Snyderwine; Robert J Turesky; Kenneth W Turteltaub; CD Davis; N Sadrieh; Herman A J Schut; M Nagao; T Sugimura; Unnur P Thorgeirsson; RH Adamson; Snorri S Thorgeirsson
Metabolism of food-derived heterocyclic amines in nonhuman primates.
Mutation research 1997;376(1-2):203-10.
1997: M Omori; RP Evarts; N Omori; Z Hu; E R Marsden; Snorri S Thorgeirsson
Expression of alpha-fetoprotein and stem cell factor/c-kit system in bile duct ligated young rats.
Hepatology (Baltimore, Md.) 1997;25(5):1115-22.
1997: M Omori; N Omori; RP Evarts; T Teramoto; Snorri S Thorgeirsson
Coexpression of flt-3 ligand/flt-3 and SCF/c-kit signal transduction system in bile-duct-ligated SI and W mice.
The American journal of pathology 1997;150(4):1179-87.
1997: JT Woitach; Elizabeth A Conner; PJ Wirth; Snorri S Thorgeirsson
Aberrant expression and regulation of hepatic epidermal growth factor receptor in a c-myc transgenic mouse model.
Journal of cellular biochemistry 1997;64(4):651-60.
1997: J A Spiewak Rinaudo; Snorri S Thorgeirsson
Detection of a tyrosine-phosphorylated form of cyclin A during liver regeneration.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(3):301-9.
1997: Snorri S Thorgeirsson; E Santoni-Rugiu; CD Davis; Elizabeth G Snyderwine
Hepatic tumor induction in c-myc mono-transgenic and TGF-alpha/c-myc double-transgenic mice.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1997;19():359-66.
1996: Dieter Schrenk; A Michalke; T W Gant; P C Brown; J A Silverman; Snorri S Thorgeirsson
Multidrug resistance gene expression in rodents and rodent hepatocytes treated with mitoxantrone.
Biochemical pharmacology 1996;52(9):1453-60.
1996: R P Evarts; Z Hu; N Omori; M Omori; E R Marsden; Snorri S Thorgeirsson
Precursor-product relationship between oval cells and hepatocytes: comparison between tritiated thymidine and bromodeoxyuridine as tracers.
Carcinogenesis 1996;17(10):2143-51.
1996: CD Davis; E J Dacquel; Herman A J Schut; Snorri S Thorgeirsson; Elizabeth G Snyderwine
In vivo mutagenicity and DNA adduct levels of heterocyclic amines in Muta mice and c-myc/lacZ double transgenic mice.
Mutation research 1996;356(2):287-96.
1996: E Santoni-Rugiu; K H Preisegger; A Kiss; T Audolfsson; Goshi Shiota; Emmett V Schmidt; Snorri S Thorgeirsson
Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9577-82.
1996: Snorri S Thorgeirsson
Hepatic stem cells in liver regeneration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(11):1249-56.
1996: H Ohgaki; N D Sanderson; P Ton; Snorri S Thorgeirsson
Molecular analyses of liver tumors in c-myc transgenic mice and c-myc and TGF-alpha double transgenic mice.
Cancer letters 1996;106(1):43-9.
1996: E Santoni-Rugiu; Péter Nagy; Michael Rugaard Jensen; Valentina M Factor; Snorri S Thorgeirsson
Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha.
The American journal of pathology 1996;149(2):407-28.
1996: Snorri S Thorgeirsson; E Santoni-Rugiu
Transgenic mouse models in carcinogenesis: interaction of c-myc with transforming growth factor alpha and hepatocyte growth factor in hepatocarcinogenesis.
British journal of clinical pharmacology 1996;42(1):43-52.
1996: K H Preisegger; Conny Stumptner; D Riegelnegg; P C Brown; J A Silverman; Snorri S Thorgeirsson; Helmut Denk
Experimental Mallory body formation is accompanied by modulation of the expression of multidrug-resistance genes and their products.
Hepatology (Baltimore, Md.) 1996;24(1):248-52.
1996: N Omori; R P Evarts; M Omori; Z Hu; E R Marsden; Snorri S Thorgeirsson
Expression of leukemia inhibitory factor and its receptor during liver regeneration in the adult rat.
Laboratory investigation; a journal of technical methods and pathology 1996;75(1):15-24.
1996: Erwin P Böttinger; Valentina M Factor; M L Tsang; J A Weatherbee; Jeffrey B Kopp; S W Qian; Lalage M Wakefield; Anita B Roberts; Snorri S Thorgeirsson; Michael B. Sporn
The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):5877-82.
1996: Hanne Cathrine Bisgaard; Snorri S Thorgeirsson
Hepatic regeneration. The role of regeneration in pathogenesis of chronic liver diseases.
Clinics in laboratory medicine 1996;16(2):325-39.
1996: Jeffrey B Kopp; Valentina M Factor; Miklós Mózes; Péter Nagy; N Sanderson; Erwin P Böttinger; Paul Klotman; Snorri S Thorgeirsson
Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease.
Laboratory investigation; a journal of technical methods and pathology 1996;74(6):991-1003.
1996: C Y Kao; Valentina M Factor; Snorri S Thorgeirsson
Reduced growth capacity of hepatocytes from c-myc and c-myc/TGF-alpha transgenic mice in primary culture.
Biochemical and biophysical research communications 1996;222(1):64-70.
1996: Z Hu; R P Evarts; Kozo Fujio; N Omori; M Omori; E R Marsden; Snorri S Thorgeirsson
Expression of transforming growth factor alpha/epidermal growth factor receptor, hepatocyte growth factor/c-met and acidic fibroblast growth factor/fibroblast growth factor receptors during hepatocarcinogenesis.
Carcinogenesis 1996;17(5):931-8.
1996: L M Sargent; Yvonne P Dragan; Carol Sattler; N Bahnub; G Sattler; P Martin; A Cisneros; J Mann; Snorri S Thorgeirsson; V C Jordan; Henry C Pitot
Induction of hepatic aneuploidy in vivo by tamoxifen, toremifene and idoxifene in female Sprague-Dawley rats.
Carcinogenesis 1996;17(5):1051-6.
1996: L M Sargent; N D Sanderson; Snorri S Thorgeirsson
Ploidy and karyotypic alterations associated with early events in the development of hepatocarcinogenesis in transgenic mice harboring c-myc and transforming growth factor alpha transgenes.
Cancer research 1996;56(9):2137-42.
1996: Kozo Fujio; Z Hu; R P Evarts; E R Marsden; C H Niu; Snorri S Thorgeirsson
Coexpression of stem cell factor and c-kit in embryonic and adult liver.
Experimental cell research 1996;224(2):243-50.
1996: Péter Nagy; Hanne Cathrine Bisgaard; E Santoni-Rugiu; Snorri S Thorgeirsson
In vivo infusion of growth factors enhances the mitogenic response of rat hepatic ductal (oval) cells after administration of 2-acetylaminofluorene.
Hepatology (Baltimore, Md.) 1996;23(1):71-9.
1996: Hanne Cathrine Bisgaard; Péter Nagy; E Santoni-Rugiu; Snorri S Thorgeirsson
Proliferation, apoptosis, and induction of hepatic transcription factors are characteristics of the early response of biliary epithelial (oval) cells to chemical carcinogens.
Hepatology (Baltimore, Md.) 1996;23(1):62-70.
1995: R P Evarts; Z Hu; N Omori; M Omori; E R Marsden; Snorri S Thorgeirsson
Effect of vitamin A deficiency on the integrity of hepatocytes after partial hepatectomy.
The American journal of pathology 1995;147(3):699-706.
1995: Z Hu; R P Evarts; Kozo Fujio; E R Marsden; Snorri S Thorgeirsson
Expression of fibroblast growth factor receptors flg and bek during hepatic ontogenesis and regeneration in the rat.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(8):1019-25.
1995: T W Gant; C K O'Connor; R Corbitt; U Thorgeirsson; Snorri S Thorgeirsson
In vivo induction of liver P-glycoprotein expression by xenobiotics in monkeys.
Toxicology and applied pharmacology 1995;133(2):269-76.
1995: N Sanderson; Valentina M Factor; Péter Nagy; J Kopp; P Kondaiah; Lalage M Wakefield; Anita B Roberts; Michael B. Sporn; Snorri S Thorgeirsson
Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2572-6.
1995: Snorri S Thorgeirsson
Target cell populations in virus-associated hepatocarcinogenesis.
Princess Takamatsu symposia 1995;25():163-70.
1995: RH Adamson; A Farb; R Virmani; Elizabeth G Snyderwine; Snorri S Thorgeirsson; S Takayama; T Sugimura; DW Dalgard; Unnur P Thorgeirsson
Studies on the carcinogenic and myocardial effects of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) in nonhuman primates.
Princess Takamatsu symposia 1995;23():260-7.
1995: Snorri S Thorgeirsson; CD Davis; Herman A J Schut; RH Adamson; Elizabeth G Snyderwine
Possible relationship between tissue distribution of DNA adducts and genotoxicity of food-derived heterocyclic amines.
Princess Takamatsu symposia 1995;23():85-92.
1994: Dieter Schrenk; T W Gant; A Michalke; A Orzechowski; J A Silverman; N Battula; Snorri S Thorgeirsson
Metabolic activation of 2-acetylaminofluorene is required for induction of multidrug resistance gene expression in rat liver cells.
Carcinogenesis 1994;15(11):2541-6.
1994: A Ghoshal; K H Preisegger; S Takayama; Snorri S Thorgeirsson; Elizabeth G Snyderwine
Induction of mammary tumors in female Sprague-Dawley rats by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and effect of dietary fat.
Carcinogenesis 1994;15(11):2429-33.
1994: T W Gant; Dieter Schrenk; J A Silverman; Snorri S Thorgeirsson
Requirement for metabolic activation of acetylaminofluorene to induce multidrug gene expression.
Environmental health perspectives 1994;102 Suppl 6():209-12.
1994: T B Tan; P A Marino; R Padmanabhan; Lori L Hampton; J M Hanley-Hyde; Snorri S Thorgeirsson
Constitutive over-expression of transforming growth factor-alpha in rat liver epithelial cells leads to increased cell cycling without transformation.
In vitro cellular & developmental biology. Animal 1994;30A(9):615-21.
1994: Péter Nagy; Hanne Cathrine Bisgaard; Snorri S Thorgeirsson
Expression of hepatic transcription factors during liver development and oval cell differentiation.
The Journal of cell biology 1994;126(1):223-33.
1994: C C Hsia; Snorri S Thorgeirsson; E Tabor
Expression of hepatitis B surface and core antigens and transforming growth factor-alpha in "oval cells" of the liver in patients with hepatocellular carcinoma.
Journal of medical virology 1994;43(3):216-21.
1994: M Zhang; Snorri S Thorgeirsson
Modulation of connexins during differentiation of oval cells into hepatocytes.
Experimental cell research 1994;213(1):37-42.
1994: Hanne Cathrine Bisgaard; P T Ton; Péter Nagy; Snorri S Thorgeirsson
Phenotypic modulation of keratins, vimentin, and alpha-fetoprotein in cultured rat liver epithelial cells after chemical, oncogene, and spontaneous transformation.
Journal of cellular physiology 1994;159(3):485-94.
1994: Hanne Cathrine Bisgaard; Péter Nagy; P T Ton; Z Hu; Snorri S Thorgeirsson
Modulation of keratin 14 and alpha-fetoprotein expression during hepatic oval cell proliferation and liver regeneration.
Journal of cellular physiology 1994;159(3):475-84.
1994: Y Fujimoto; Lori L Hampton; Elizabeth G Snyderwine; M Nagao; T Sugimura; RH Adamson; Snorri S Thorgeirsson
p53 gene mutation in hepatocellular carcinoma induced by 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates.
Japanese journal of cancer research : Gann 1994;85(5):506-9.
1994: Z Hu; Kozo Fujio; E R Marsden; Snorri S Thorgeirsson; R P Evarts
Hepatic regeneration in vitamin A-deficient rats: changes in the expression of transforming growth factor alpha/epidermal growth factor receptor and retinoic acid receptors alpha and beta.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(5):503-8.
1994: Kozo Fujio; R P Evarts; Z Hu; E R Marsden; Snorri S Thorgeirsson
Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat.
Laboratory investigation; a journal of technical methods and pathology 1994;70(4):511-6.
1994: C D Davis; A Farb; Snorri S Thorgeirsson; R Virmani; E G Snyderwine
Cardiotoxicity of heterocyclic amine food mutagens in cultured myocytes and in rats.
Toxicology and applied pharmacology 1994;124(2):201-11.
1994: Y Fujimoto; Lori L Hampton; PJ Wirth; N J Wang; J P Xie; Snorri S Thorgeirsson
Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China.
Cancer research 1994;54(1):281-5.
1994: Snorri S Thorgeirsson; T W Gant; J A Silverman
Transcriptional regulation of multidrug resistance gene expression.
Cancer treatment and research 1994;73():57-68.
1993: Kazuhiro Nouso; N Battula; Snorri S Thorgeirsson; T Higashi; Takao Tsuji
Recombinant mouse cytochromes P1-450 and P3-450: enzymatic characterization of the hemoprotein expressed in human cells infected with recombinant vaccinia virus.
Acta medica Okayama 1993;47(6):377-82.
1993: Snorri S Thorgeirsson; R P Evarts; Hanne Cathrine Bisgaard; Kozo Fujio; Z Hu
Hepatic stem cell compartment: activation and lineage commitment.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1993;204(3):253-60.
1993: Harushige Nakatsukasa; J A Silverman; T W Gant; R P Evarts; Snorri S Thorgeirsson
Expression of multidrug resistance genes in rat liver during regeneration and after carbon tetrachloride intoxication.
Hepatology (Baltimore, Md.) 1993;18(5):1202-7.
1993: P C Brown; Snorri S Thorgeirsson; J A Silverman
Cloning and regulation of the rat mdr2 gene.
Nucleic acids research 1993;21(16):3885-91.
1993: R P Evarts; Z Hu; Kozo Fujio; E R Marsden; Snorri S Thorgeirsson
Activation of hepatic stem cell compartment in the rat: role of transforming growth factor alpha, hepatocyte growth factor, and acidic fibroblast growth factor in early proliferation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(7):555-61.
1993: Z Hu; R P Evarts; Kozo Fujio; E R Marsden; Snorri S Thorgeirsson
Expression of hepatocyte growth factor and c-met genes during hepatic differentiation and liver development in the rat.
The American journal of pathology 1993;142(6):1823-30.
1993: Snorri S Thorgeirsson
Hepatic stem cells.
The American journal of pathology 1993;142(5):1331-3.
1993: Dieter Schrenk; T W Gant; K H Preisegger; J A Silverman; P A Marino; Snorri S Thorgeirsson
Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates.
Hepatology (Baltimore, Md.) 1993;17(5):854-60.
1993: H Murakami; N D Sanderson; Péter Nagy; P A Marino; Glenn Merlino; Snorri S Thorgeirsson
Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis.
Cancer research 1993;53(8):1719-23.
1993: CD Davis; Herman A J Schut; RH Adamson; Unnur P Thorgeirsson; Snorri S Thorgeirsson; Elizabeth G Snyderwine
Mutagenic activation of IQ, PhIP and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo.
Carcinogenesis 1993;14(1):61-5.
1993: N C Popescu; J A Silverman; Snorri S Thorgeirsson
Mapping of a rat multidrug resistance gene by fluorescence in situ hybridization.
Genomics 1993;15(1):182-4.
1993: Hanne Cathrine Bisgaard; D C Parmelee; H A Dunsford; S Sechi; Snorri S Thorgeirsson
Keratin 14 protein in cultured nonparenchymal rat hepatic epithelial cells: characterization of keratin 14 and keratin 19 as antigens for the commonly used mouse monoclonal antibody OV-6.
Molecular carcinogenesis 1993;7(1):60-6.
1992: C C Hsia; R P Evarts; Harushige Nakatsukasa; E R Marsden; Snorri S Thorgeirsson
Occurrence of oval-type cells in hepatitis B virus-associated human hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 1992;16(6):1327-33.
1992: Snorri S Thorgeirsson
The LEC rat--an animal model for human hepatitis and hepatocellular carcinoma.
Japanese journal of cancer research : Gann 1992;83(10):inside front cover.
1992: E R Marsden; Z Hu; Kozo Fujio; Harushige Nakatsukasa; Snorri S Thorgeirsson; R P Evarts
Expression of acidic fibroblast growth factor in regenerating liver and during hepatic differentiation.
Laboratory investigation; a journal of technical methods and pathology 1992;67(4):427-33.
1992: T W Gant; J A Silverman; Snorri S Thorgeirsson
Regulation of P-glycoprotein gene expression in hepatocyte cultures and liver cell lines by a trans-acting transcriptional repressor.
Nucleic acids research 1992;20(11):2841-6.
1992: Kazuhiro Nouso; Snorri S Thorgeirsson; N Battula
Stable expression of human cytochrome P450IIE1 in mammalian cells: metabolic activation of nitrosodimethylamine and formation of adducts with cellular DNA.
Cancer research 1992;52(7):1796-800.
1992: Elizabeth G Snyderwine; Herman A J Schut; RH Adamson; Unnur P Thorgeirsson; Snorri S Thorgeirsson
Metabolic activation and genotoxicity of heterocyclic arylamines.
Cancer research 1992;52(7 Suppl):2099s-2102s.
1992: Y Fujimoto; Lori L Hampton; L D Luo; PJ Wirth; Snorri S Thorgeirsson
Low frequency of p53 gene mutation in tumors induced by aflatoxin B1 in nonhuman primates.
Cancer research 1992;52(4):1044-6.
1992: A O Williams; A C Huggett; Snorri S Thorgeirsson
Pathology of spontaneous and oncogene transformed rat liver epithelial cells and derived tumours in nude mice.
International journal of experimental pathology 1992;73(1):99-114.
1992: R P Evarts; Harushige Nakatsukasa; E R Marsden; Z Hu; Snorri S Thorgeirsson
Expression of transforming growth factor-alpha in regenerating liver and during hepatic differentiation.
Molecular carcinogenesis 1992;5(1):25-31.
1992: G H Kalimi; Lori L Hampton; James E Trosko; Snorri S Thorgeirsson; A C Huggett
Homologous and heterologous gap-junctional intercellular communication in v-raf-, v-myc-, and v-raf/v-myc-transduced rat liver epithelial cell lines.
Molecular carcinogenesis 1992;5(4):301-10.
1992: Harushige Nakatsukasa; R P Evarts; Richard K Burt; Péter Nagy; Snorri S Thorgeirsson
Cellular pattern of multidrug-resistance gene expression during chemical hepatocarcinogenesis in the rat.
Molecular carcinogenesis 1992;6(3):190-8.
1991: Harushige Nakatsukasa; R P Evarts; C C Hsia; E Marsden; Snorri S Thorgeirsson
Expression of transforming growth factor-beta 1 during chemical hepatocarcinogenesis in the rat.
Laboratory investigation; a journal of technical methods and pathology 1991;65(5):511-7.
1991: A C Huggett; P A Ellis; C P Ford; Lori L Hampton; D Rimoldi; Snorri S Thorgeirsson
Development of resistance to the growth inhibitory effects of transforming growth factor beta 1 during the spontaneous transformation of rat liver epithelial cells.
Cancer research 1991;51(21):5929-36.
1991: J A Silverman; H Raunio; T W Gant; Snorri S Thorgeirsson
Cloning and characterization of a member of the rat multidrug resistance (mdr) gene family.
Gene 1991;106(2):229-36.
1991: Hanne Cathrine Bisgaard; Snorri S Thorgeirsson
Evidence for a common cell of origin for primitive epithelial cells isolated from rat liver and pancreas.
Journal of cellular physiology 1991;147(2):333-43.
1991: N Battula; Herman A J Schut; Snorri S Thorgeirsson
Cytochrome P4501A2 constitutively expressed from transduced DNA mediates metabolic activation and DNA-adduct formation of aromatic amine carcinogens in NIH 3T3 cells.
Molecular carcinogenesis 1991;4(5):407-14.
1991: T W Gant; J A Silverman; Hanne Cathrine Bisgaard; Richard K Burt; P A Marino; Snorri S Thorgeirsson
Regulation of 2-acetylaminofluorene-and 3-methylcholanthrene--mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver.
Molecular carcinogenesis 1991;4(6):499-509.
1991: Snorri S Thorgeirsson; J A Silverman; T W Gant; P A Marino
Multidrug resistance gene family and chemical carcinogens.
Pharmacology & therapeutics 1991;49(3):283-92.
1990: A C Huggett; Lori L Hampton; C P Ford; PJ Wirth; Snorri S Thorgeirsson
Altered responsiveness of rat liver epithelial cells to transforming growth factor beta 1 following their transformation with v-raf.
Cancer research 1990;50(23):7468-75.
1990: Lori L Hampton; P J Worland; B Yu; Snorri S Thorgeirsson; A C Huggett
Expression of growth-related genes during tumor progression in v-raf-transformed rat liver epithelial cells.
Cancer research 1990;50(23):7460-7.
1990: Harushige Nakatsukasa; R P Evarts; C C Hsia; Snorri S Thorgeirsson
Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver.
Laboratory investigation; a journal of technical methods and pathology 1990;63(2):171-80.
1990: M S Chapekar; A C Huggett; C C Cheng; Lori L Hampton; K H Lin; Snorri S Thorgeirsson
Isolation and characterization of a rat liver epithelial cell line resistant to the antiproliferative effects of transforming growth factor beta (type 1).
Cancer research 1990;50(12):3600-4.
1990: Harushige Nakatsukasa; Péter Nagy; R P Evarts; C C Hsia; E Marsden; Snorri S Thorgeirsson
Cellular distribution of transforming growth factor-beta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis.
The Journal of clinical investigation 1990;85(6):1833-43.
1990: R P Evarts; Harushige Nakatsukasa; E R Marsden; C C Hsia; H A Dunsford; Snorri S Thorgeirsson
Cellular and molecular changes in the early stages of chemical hepatocarcinogenesis in the rat.
Cancer research 1990;50(11):3439-44.
1990: N Battula; G K Townsend; Herman A J Schut; Elizabeth G Snyderwine; Snorri S Thorgeirsson
Role of recombinant cytochromes P4501A1 and P4501A2 in the metabolism and genotoxicity of food derived mutagens.
Progress in clinical and biological research 1990;340E():127-37.
1990: P J Worland; Lori L Hampton; Snorri S Thorgeirsson; A C Huggett
Development of an in vitro model of tumor progression using v-raf and v-raf/v-myc transformed rat liver epithelial cells: correlation of tumorigenicity with the downregulation of specific proteins.
Molecular carcinogenesis 1990;3(1):20-9.
1990: N Battula; G K Townsend; Elizabeth G Snyderwine; Herman A J Schut; Snorri S Thorgeirsson
Preferential activation and genotoxicity of food derived heterocyclic amine mutagens by recombinant cytochrome P4501A2.
Progress in clinical and biological research 1990;347():55-69.
1990: RH Adamson; Elizabeth G Snyderwine; Unnur P Thorgeirsson; Herman A J Schut; Robert J Turesky; Snorri S Thorgeirsson; S Takayama; T Sugimura
Metabolic processing and carcinogenicity of heterocyclic amines in nonhuman primates.
Princess Takamatsu symposia 1990;21():289-301.
1990: RH Adamson; Unnur P Thorgeirsson; Elizabeth G Snyderwine; Snorri S Thorgeirsson; J Reeves; DW Dalgard; S Takayama; T Sugimura
Carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates: induction of tumors in three macaques.
Japanese journal of cancer research : Gann 1990;81(1):10-4.
1989: M S Chapekar; A C Huggett; Snorri S Thorgeirsson
Growth modulatory effects of a liver-derived growth inhibitor, transforming growth factor beta 1, and recombinant tumor necrosis factor alpha, in normal and neoplastic cells.
Experimental cell research 1989;185(1):247-57.
1989: G Fassina; Peter P Roller; A D Olson; Snorri S Thorgeirsson; James G. Omichinski
Recognition properties of peptides hydropathically complementary to residues 356-375 of the c-raf protein.
The Journal of biological chemistry 1989;264(19):11252-7.
1989: T Benjamin; C H Niu; D C Parmelee; A C Huggett; B Yu; P P Roller; Snorri S Thorgeirsson
Direct N-terminal sequence analysis of rat liver plasma membrane glycoproteins separated by two-dimensional polyacrylamide gel electrophoresis.
Electrophoresis 1989;10(7):447-55.
1989: B E Huber; Carole Heilman; Snorri S Thorgeirsson
Poly(A+)RNA levels of growth-, differentiation- and transformation-associated genes in the progressive development of hepatocellular carcinoma in the rat.
Hepatology (Baltimore, Md.) 1989;9(5):756-62.
1989: R P Evarts; Péter Nagy; Harushige Nakatsukasa; E Marsden; Snorri S Thorgeirsson
In vivo differentiation of rat liver oval cells into hepatocytes.
Cancer research 1989;49(6):1541-7.
1989: P J Worland; D Bronzert; Robert B Dickson; Marc Lippman; Lori L Hampton; Snorri S Thorgeirsson; PJ Wirth
Secreted and cellular polypeptide patterns of MCF-7 human breast cancer cells following either estrogen stimulation or v-H-ras transfection.
Cancer research 1989;49(1):51-7.
1989: A C Huggett; C P Ford; Snorri S Thorgeirsson
Effects of interleukin-6 on the growth of normal and transformed rat liver cells in culture.
Growth factors (Chur, Switzerland) 1989;2(1):83-9.
1989: Péter Nagy; R P Evarts; J B McMahon; Snorri S Thorgeirsson
Role of TGF-beta in normal differentiation and oncogenesis in rat liver.
Molecular carcinogenesis 1989;2(6):345-54.
1988: Richard K Burt; Susan H Garfield; K Johnson; Snorri S Thorgeirsson
Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals.
Carcinogenesis 1988;9(12):2329-32.
1988: Richard K Burt; Snorri S Thorgeirsson
Coinduction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics.
Journal of the National Cancer Institute 1988;80(17):1383-6.
1988: Péter Nagy; R P Evarts; E Marsden; J Roach; Snorri S Thorgeirsson
Cellular distribution of c-myc transcripts during chemical hepatocarcinogenesis in rats.
Cancer research 1988;48(19):5522-7.
1988: Elizabeth G Snyderwine; K Yamashita; RH Adamson; S Sato; M Nagao; T Sugimura; Snorri S Thorgeirsson
Use of the 32P-postlabeling method to detect DNA adducts of 2-amino-3-methylimidazolo[4,5-f]quinoline (IQ) in monkeys fed IQ: identification of the N-(deoxyguanosin-8-yl)-IQ adduct.
Carcinogenesis 1988;9(10):1739-43.
1988: M J Miller; D M Schwartz; Snorri S Thorgeirsson
Inter- and intraclonal variability of polypeptides synthesized in a rat hepatoma cell line. Quantitative two-dimensional gel analysis.
The Journal of biological chemistry 1988;263(23):11227-36.
1988: Elizabeth G Snyderwine; P P Roller; RH Adamson; S Sato; Snorri S Thorgeirsson
Reaction of N-hydroxylamine and N-acetoxy derivatives of 2-amino-3-methylimidazolo[4,5-f]quinoline with DNA. Synthesis and identification of N-(deoxyguanosin-8-yl)-IQ.
Carcinogenesis 1988;9(6):1061-5.
1988: Reidar Albrechtsen; U M Wewer; Snorri S Thorgeirsson
De novo deposition of laminin-positive basement membrane in vitro by normal hepatocytes and during hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 1988;8(3):538-46.
1988: Elizabeth G Snyderwine; PJ Wirth; P P Roller; RH Adamson; S Sato; Snorri S Thorgeirsson
Mutagenicity and in vitro covalent DNA binding of 2-hydroxyamino-3-methylimidazolo[4,5-f]quinoline.
Carcinogenesis 1988;9(3):411-8.
1988: Susan H Garfield; B E Huber; Péter Nagy; M G Cordingley; Snorri S Thorgeirsson
Neoplastic transformation and lineage switching of rat liver epithelial cells by retrovirus-associated oncogenes.
Molecular carcinogenesis 1988;1(3):189-95.
1987: H Raunio; R Konno; Kaija Linnainmaa; P J Wirth; Snorri S Thorgeirsson
Heterogeneity of intercellular adhesion in rat liver cells in culture.
Experimental cell research 1987;173(2):596-605.
1987: A C Huggett; Henry C Krutzsch; Snorri S Thorgeirsson
Characterization of a hepatic proliferation inhibitor (HPI): effect of HPI on the growth of normal liver cells--comparison with transforming growth factor beta.
Journal of cellular biochemistry 1987;35(4):305-14.
1987: R P Evarts; Péter Nagy; E Marsden; Snorri S Thorgeirsson
A precursor-product relationship exists between oval cells and hepatocytes in rat liver.
Carcinogenesis 1987;8(11):1737-40.
1987: R P Evarts; Péter Nagy; E Marsden; Snorri S Thorgeirsson
In situ hybridization studies on expression of albumin and alpha-fetoprotein during the early stage of neoplastic transformation in rat liver.
Cancer research 1987;47(20):5469-75.
1987: M Falzon; V T Vu; P P Roller; Snorri S Thorgeirsson
Relationship between 7,12-dimethyl- and 7,8,12-trimethylbenz[a]anthracene DNA adduct formation in hematopoietic organs and leukemogenic effects.
Cancer letters 1987;37(1):41-9.
1986: B E Huber; Carole Heilman; P J Wirth; M J Miller; Snorri S Thorgeirsson
Studies of gene transcription and translation in regenerating rat liver.
Hepatology (Baltimore, Md.) 1986;6(2):209-19.
1986: V T Vu; P H Grantham; P P Roller; William David Hankins; P J Wirth; Snorri S Thorgeirsson
Formation of DNA adducts from N-acetoxy-2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene in rat hemopoietic tissues in vivo.
Cancer research 1986;46(1):233-8.
1986: Michael E McManus; Donald J Birkett; W M Burgess; Ieva Stupans; J A Koenig; A R Boobis; D S Davies; P J Wirth; P H Grantham; Snorri S Thorgeirsson
Flavin-containing monooxygenase activity in human liver microsomes.
Advances in experimental medicine and biology 1986;197():773-9.
1985: B E Huber; Kerry L Dearfield; J R Williams; Carole Heilman; Snorri S Thorgeirsson
Tumorigenicity and transcriptional modulation of c-myc and N-ras oncogenes in a human hepatoma cell line.
Cancer research 1985;45(9):4322-9.
1985: V T Vu; M E Møller; P H Grantham; P J Wirth; Snorri S Thorgeirsson
Association between DNA strand breaks and specific DNA adducts in murine hepatocytes following in vivo and in vitro exposure to N-hydroxy-2-acetylaminofluorene and N-acetoxy-2-acetylaminofluorene.
Carcinogenesis 1985;6(1):45-52.
1983: Michael E McManus; P H Grantham; J L Cone; P P Roller; P J Wirth; Snorri S Thorgeirsson
Guanethidine N-oxide formation as a measure of cellular flavin-containing monooxygenase activity.
Biochemical and biophysical research communications 1983;112(2):437-43.